Hub : Genes

Cd209d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Cd209d 0.13 0.06 1.0e-07 0.03 0.05 0.06 0.05 4.2e-04 1.9e-06 5.8e-07 1.8e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density0.10.20.2-0.5
Area under the delay curve1.21.41.4-1.2
BMI with tail0.72.42.4-1.6
BMI without tail2.88.58.5-2.9
Body weight7.934.534.5-5.9
Weight adjusted by age0.00.10.10.3
Bone surface1.32.42.4-1.5
Bone volume0.20.40.4-0.7
Breakpoint value in progressive ratio session1.61.91.9-1.4
Number of licking bursts0.10.10.10.4
Context. condit. distance diff. score4.55.45.4-2.3
Locomotion velocity, session 10.20.20.2-0.5
Locomotion distance, session 10.10.20.20.4
Locomotion velocity, session 20.10.10.1-0.3
Locomotion distance, session 20.40.60.60.8
Locomotion velocity, session 30.40.50.5-0.7
Locomotion distance, session 30.60.60.60.8
Stereotopy head waving bouts, day 30.20.20.2-0.4
Stereotopy head waving duration, day 30.10.10.10.3
Locomotion velocity, session 71.31.41.4-1.2
Locomotion distance, session 70.50.60.6-0.8
Stereotopy head waving bouts, day 70.00.00.00.0
Stereotopy head waving duration, day 70.10.10.10.3
Locomotion velocity, session 81.01.11.1-1.1
Locomotion distance, session 81.72.52.5-1.6
Degree of sensitization distance0.20.20.2-0.4
Degree of sensitization stereotypy0.00.00.0-0.1
Conditioned locomotion0.50.60.60.8
Cocaine response after cond. corrected0.00.10.10.2
Cocaine response after cond. not corrected0.10.10.1-0.4
Cocaine response before conditioning1.41.71.7-1.3
Saline control response0.60.80.8-0.9
Bone: connectivity density1.42.12.1-1.5
Bone: cortical apparent density0.10.10.1-0.4
Bone: cortical area3.85.85.8-2.4
Bone: cortical porosity0.10.10.10.3
Bone: cortical porosity0.10.10.10.3
Bone: cortical thickness2.44.04.0-2.0
Bone: cortical thickness1.51.81.8-1.3
Bone: cortical tissue density0.00.00.0-0.2
Condit. Reinf. active minus inactive responses0.00.00.0-0.2
Condit. Reinf. active-inactive response ratio0.30.40.4-0.6
Condit. Reinf. active responses0.00.00.0-0.2
Condit. Reinf. inactive responses0.10.10.10.3
Incentive salience index mean0.00.00.00.0
Condit. Reinf. lever presses0.00.00.00.1
Condit. Reinf. active minus inactive responses3.85.05.0-2.2
Condit. Reinf. active-inactive response ratio2.63.03.0-1.7
Condit. Reinf. active responses4.46.16.1-2.5
Condit. Reinf. inactive responses0.70.90.9-0.9
Condit. Reinf. lever presses0.91.21.2-1.1
Condit. Reinf. lever reinforcers received3.75.15.1-2.3
Conditioned reinforcement - actives1.01.71.7-1.3
Conditioned reinforcement - inactives0.30.40.40.6
Conditioned locomotion1.31.61.6-1.3
Patch foraging indifference point 0 sec1.42.72.71.6
Patch foraging indifference point AUC0.20.30.3-0.5
Delay disc. indifference point, 0s delay4.24.74.7-2.2
Delay disc. indifference point, 16s delay0.30.40.4-0.6
Delay disc. indifference point, 2s delay1.41.61.6-1.3
Delay disc. indifference point, 24s delay0.00.00.0-0.0
Delay disc. indifference point, 4s delay1.01.01.0-1.0
Delay disc. indifference point, 8s delay0.20.30.3-0.5
Indifference point function ln k0.10.10.10.4
Indifference point function log k0.10.10.10.4
Patch foraging total patch changes 0 sec2.03.83.82.0
Patch foraging total patch changes 12 sec0.40.50.50.7
Patch foraging total patch changes 18 sec1.31.91.91.4
Patch foraging total patch changes 24 sec1.01.71.71.3
Patch foraging total patch changes 6 sec0.71.11.11.0
Patch foraging time to switch 0 sec0.00.00.00.0
Patch foraging water rate 0 sec0.00.10.10.3
Patch foraging water rate 12 sec0.00.00.00.2
Patch foraging water rate 18 sec0.10.20.2-0.4
Patch foraging water rate 24 sec0.20.30.3-0.5
Patch foraging water rate 6 sec0.00.00.00.1
Seeking ratio, delayed vs. immediate footshock4.15.05.02.2
Distance traveled before self-admin0.00.00.0-0.1
Distance traveled after self-admin0.10.10.1-0.3
Extensor digitorum longus weight3.513.813.8-3.7
Bone: elastic displacement0.10.10.1-0.2
Bone: elastic work1.11.51.5-1.2
Bone: endosteal estimation0.00.00.00.0
Bone: endosteal perimeter0.40.90.9-0.9
Epididymis fat weight0.10.20.2-0.4
Delta time in closed arm before/after self-admin1.91.81.8-1.3
Delta time in open arm before/after self-admin2.92.92.91.7
Diff in mean of infusions in LGA sessions0.20.30.3-0.5
Delay discount exponential model param1.01.11.11.1
Extinction: sum of active levers before priming0.20.20.2-0.5
Active lever presses in extinction session 60.00.00.0-0.1
Bone: final force2.23.53.5-1.9
Bone: final moment1.62.52.5-1.6
Food consumed during 24 hour testing period0.40.50.50.7
Glucose0.00.00.00.0
Heart weight0.40.60.6-0.8
Delay discount hyperbolic model param1.11.21.21.1
Intermittent access intake day 1-15 change0.00.00.00.2
Intermittent access intake escalation0.00.00.00.2
Intermittent access intake escalation 20.30.40.40.6
Intermitt. access day 1 inactive lever presses0.20.60.60.8
Intermitt. access day 15 inactive lever presses0.30.60.60.8
Intermitt. access escalation Index0.00.00.0-0.1
Intermittent access day 1 total infusions0.00.00.0-0.1
Intermittent access day 15 total infusions0.00.00.0-0.0
Intermittent access terminal intake (last 3 days)0.00.00.0-0.1
Intermittent access total infusions0.20.20.2-0.5
Intermittent access day 1 locomotion0.00.00.0-0.2
Intermittent access day 15 total locomotion0.00.10.1-0.2
Intermittent access total locomotion0.00.10.1-0.2
Intermittent access standard deviation0.51.01.01.0
Left kidney weight3.315.315.3-3.9
Right kidney weight3.113.913.9-3.7
Cocaine induced anxiety0.60.80.8-0.9
Post-drug Anxiety1.21.31.3-1.1
Baseline Anxiety0.00.00.00.1
Tail length5.822.622.6-4.8
Length with tail9.842.442.4-6.5
Length without tail3.511.311.3-3.4
Times rat made contact with spout1.41.61.6-1.3
Lifetime Intake0.00.00.0-0.2
Liver weight, left0.10.20.20.5
Liver weight, right0.40.70.7-0.9
Locomotor activity2.33.53.5-1.9
Locomotor testing distance0.00.10.1-0.3
Locomotor testing rearing0.51.01.01.0
Locomotion in novel chamber0.00.00.00.0
Locomotion in novel chamber post-restriction1.32.12.1-1.5
Fecal boli incidents, locomotor time 11.21.71.7-1.3
Change in fecal boli incidents, locomotor task0.10.10.10.4
Time >=10cm from walls, locomotor time 10.10.10.1-0.3
Bouts of movement, locomotor time 10.81.01.0-1.0
Total resting periods, locomotor time 11.11.21.2-1.1
Rest time, locomotor task time 11.11.41.4-1.2
Distance moved, locomotor task time 10.00.00.00.1
Vertical activity count, locomotor time 10.00.10.1-0.3
Time >=10cm from walls, locomotor time 21.82.72.7-1.6
Bouts of movement, locomotor time 20.30.50.5-0.7
Total resting periods, locomotor time 20.10.20.2-0.5
Rest time, locomotor task time 20.00.00.00.1
Distance moved, locomotor task time 20.00.00.00.2
Vertical activity count, locomotor time 20.20.30.3-0.5
Light reinforcement 10.20.50.5-0.7
Light reinforcement 20.30.50.50.7
Bone: marrow area0.00.00.00.1
Bone: maximum diameter0.91.71.7-1.3
Bone: maximum force1.32.32.3-1.5
Bone: maximum moment0.91.51.5-1.2
Mean time between licks in bursts0.71.81.81.3
Mean num. licks in bursts0.30.40.4-0.7
Cd content in liver0.20.20.2-0.4
Co content in liver2.22.62.61.6
Cu content in liver0.10.10.10.4
Fe content in liver1.21.41.4-1.2
K content in liver0.30.30.3-0.6
Mg content in liver0.30.30.3-0.5
Mn content in liver0.40.40.40.6
Na content in liver0.80.80.8-0.9
Rb content in liver0.80.90.90.9
Se content in liver4.65.55.5-2.3
Sr content in liver0.30.30.30.5
Zn content in liver0.10.10.1-0.4
Bone: minimum diameter0.00.00.00.1
Time in familiar zone, hab. session 12.22.12.11.5
Time in novel zone, hab. session 11.81.81.8-1.3
Total zone transitions, hab. session 10.00.00.00.1
Total locomotion distance, hab. session 10.10.10.1-0.3
Locomotion velocity, hab. session 10.00.00.0-0.1
Time in familiar zone, hab. session 20.10.10.10.2
Time in novel zone, hab. session 20.00.00.0-0.2
Total zone transitions, hab. session 20.10.20.2-0.4
Total locomotion distance, hab. session 20.00.00.0-0.1
Locomotion velocity, hab. session 20.00.00.00.0
Novel to familiar place preference ratio0.00.00.0-0.2
Novelty place preference0.00.00.00.0
Time in novel zone, NPP test0.00.00.0-0.2
Total zone transitions, NPP test0.30.40.4-0.7
Total locomotion distance, NPP test1.01.41.4-1.2
Locomotion velocity, NPP test0.91.31.3-1.2
Intraocular pressure0.30.40.4-0.6
Delta distance traveled before/after self-admin0.10.10.10.4
Delta ambulatory time before/after self-admin0.60.80.80.9
Parametrial fat weight0.00.10.1-0.3
Pavlov. Cond. lever latency0.30.40.4-0.6
Pavlov. Cond. magazine entry latency0.40.50.5-0.7
Pavlov. Cond. change in total contacts0.30.30.3-0.6
Pavlov. Cond. index score0.10.10.1-0.3
Pavlov. Cond. latency score0.10.10.1-0.3
Pavlov. Cond. lever contacts0.10.20.20.4
Pavlov. Cond. magazine entry number0.50.70.70.8
Pavlov. Cond. intertrial magazine entries0.91.01.01.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.1-0.3
Pavlov. Cond. response bias0.30.40.4-0.6
Pavlov. Cond. lever latency0.91.31.31.1
Pavlov. Cond. magazine entry latency0.40.50.5-0.7
Pavlov. Cond. change in total contacts0.30.50.5-0.7
Pavlov. Cond. index score0.40.60.6-0.8
Pavlov. Cond. latency score0.50.60.6-0.8
Pavlov. Cond. lever contacts1.01.41.4-1.2
Pavlov. Cond. magazine entry number0.10.10.10.3
Pavlov. Cond. intertrial magazine entries0.10.20.2-0.4
Pavlov. Cond. lever-magazine prob. diff.0.50.60.6-0.8
Pavlov. Cond. response bias0.91.21.2-1.1
Time in closed arm before self-admin0.10.10.1-0.3
Time in closed arm after self-admin0.70.70.7-0.9
Time in open arm before self-admin0.90.90.9-1.0
Time in open arm after self-admin0.30.30.30.6
Bone: periosteal estimation1.02.12.1-1.5
Bone: periosteal perimeter1.72.82.8-1.7
Bone: post-yield work0.00.00.0-0.1
Progressive ratio test 1 active lever presses0.70.80.8-0.9
Progressive ratio test 1 breakpoint0.70.90.9-0.9
Progressive ratio test 1 inactive lever presses0.20.20.20.5
Progressive ratio test 2 active lever presses0.30.30.3-0.6
Progressive ratio test 2 breakpoint0.20.30.3-0.5
Progressive ratio test 2 inactive lever presses0.00.00.00.0
Incentive Sensitization - Responses0.10.10.10.3
Incentive Sensitization - Breakpoint0.10.10.10.3
Sum of active levers in priming session hrs 5-60.30.30.3-0.5
Progressive ratio0.60.90.91.0
Food seeking constrained by brief footshock4.96.06.02.5
Seeking ratio, punishment vs. effort0.00.00.0-0.2
Retroperitoneal fat weight0.31.31.3-1.2
Reaction time number correct0.00.10.10.3
Reaction time mean minus median2.97.27.2-2.7
Reaction time mean minus median AUC0.41.11.1-1.1
Reaction time num false alarms0.50.70.7-0.8
Reaction time num false alarms AUC0.30.40.4-0.7
Reaction time trials correct on left0.00.10.10.3
Reaction time trials on left0.00.10.10.2
Reaction time mean0.20.30.3-0.6
Reaction time mean AUC0.10.20.2-0.5
Median of all reaction times0.10.10.10.3
Reaction time omissions0.50.70.7-0.8
Reaction time false alarm rate0.50.80.8-0.9
Reaction time premature initiation rate0.30.50.5-0.7
Reaction time premature initiations0.10.20.2-0.4
Std. dev. reaction times1.52.82.8-1.7
Reaction time trials completed0.00.10.10.2
Reaction time trials AUC0.10.10.10.4
Run reversals in cocaine runway, females0.90.90.91.0
Run reversals in cocaine runway, males0.40.40.40.7
Latency to leave start box in cocaine runway0.00.00.0-0.2
Latency to leave start box in cocaine runway, F0.10.10.1-0.4
Latency to leave start box in cocaine runway, M0.10.10.10.3
Std. dev. time between licks in bursts0.10.10.1-0.3
Total sessions with >9 infusions0.20.20.20.4
Short access day 1 total inactive lever presses0.60.80.80.9
Short access day 10 total inactive lever presses0.30.80.80.9
Short access day 1 total infusions1.11.41.41.2
Short access day 10 total infusions0.10.10.10.3
Short access total infusions0.20.20.20.5
Short access day 1 locomotion0.20.20.2-0.4
Short access day 10 total locomotion0.61.01.01.0
Short access total locomotion0.00.00.00.2
One hour access (0.3 mA shock)0.00.10.10.2
Compulsive drug intake1.31.61.61.3
One hour access (shock baseline)1.01.51.5-1.2
Social response proportion7.58.58.5-2.9
Social responses2.02.62.6-1.6
Social time0.20.30.30.5
Soleus weight0.41.21.2-1.1
Bone: stiffness1.32.12.1-1.5
Tibialis anterior weight5.518.718.7-4.3
Time to tail flick, vehicle, before self-admin0.70.70.7-0.9
Time to tail flick, vehicle, after self-admin0.20.30.3-0.6
Time to tail flick, test, before self-admin0.80.80.8-0.9
Time to tail flick, test, after self-admin0.10.10.1-0.3
Delta time to tail flick, vehicle, before/after SA0.10.10.10.2
Delta time to tail flick, test, before/after SA1.01.01.01.0
Tibia length1.84.84.8-2.2
Ambulatory time before self-admin0.20.30.3-0.5
Ambulatory time after self-admin0.00.00.0-0.0
Bone: tissue strength1.71.71.71.3
Total heroin consumption0.00.00.00.1
Bone: trabecular number0.71.11.1-1.1
Bone: trabecular spacing1.82.42.41.5
Bone: trabecular thickness1.72.12.1-1.5
Bone: trabecular tissue density4.87.17.1-2.7
Water consumed over 24 hours0.20.30.3-0.6
Number of responses in last shaping day0.10.10.10.4