Cd180

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Cd180	0.04	0.03	5.9e-05	0.03	0.04	0.02	0.03	1.2e-04	7.4e-05	4.4e-03	1.3e-04
2	Brain	gene expression	Cd180	0.12	0.09	8.8e-09	0.08	0.07	0.07	0.04	1.0e-07	7.7e-07	2.8e-07	7.7e-05
3	NAcc	gene expression	Cd180	0.02	0.02	3.9e-03	0.02	0.01	0.01	-0	7.6e-04	5.4e-02	1.3e-02	6.1e-01
4	BLA	gene expression	Cd180	0.1	0.07	8.2e-04	0.03	0.03	0.04	0	1.4e-02	1.2e-02	2.0e-03	2.8e-01
5	Adipose	gene expression	Cd180	0.17	0.08	1.4e-08	0.06	0.07	0.06	0.06	1.7e-07	7.6e-08	2.1e-07	3.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.9	1.3	0.6	-0.9	-0.8	-1.2	1.1
Area under the delay curve	0.5	0.6	0.9	-0.6	0.7	0.9	0.8	-0.6
BMI with tail	1.3	4.3	6.8	1.8	-2.6	-2.5	-1.4	1.8
BMI without tail	0.7	1.4	2.5	1.1	-1.5	-1.6	-1.0	-0.2
Body weight	0.7	3.0	5.7	-2.4	1.7	1.8	1.8	0.5
Weight adjusted by age	1.4	1.6	3.5	-1.0	1.3	1.3	1.9	-0.3
Bone surface	0.9	1.6	5.9	0.0	-0.6	-0.6	-1.1	2.4
Bone volume	0.6	1.1	2.1	0.5	-0.8	-0.8	-1.4	1.4
Breakpoint value in progressive ratio session	1.4	1.6	2.3	1.4	-1.4	-1.5	-1.3	0.2
Number of licking bursts	2.6	3.0	4.9	2.1	-2.2	-2.2	-0.6	0.6
Context. condit. distance diff. score	0.9	1.1	2.3	-1.5	1.1	1.2	0.3	0.7
Locomotion velocity, session 1	0.4	0.5	1.7	-0.1	0.4	0.4	0.5	-1.3
Locomotion distance, session 1	0.1	0.1	0.2	-0.4	0.5	0.5	0.0	-0.0
Locomotion velocity, session 2	1.7	2.0	2.9	-1.3	1.6	1.5	0.8	-1.7
Locomotion distance, session 2	0.2	0.3	0.7	-0.1	0.3	0.4	-0.6	-0.8
Locomotion velocity, session 3	2.5	2.9	3.8	-1.9	1.9	1.9	1.3	-1.4
Locomotion distance, session 3	2.9	3.1	6.2	-2.5	2.0	2.0	1.2	0.2
Stereotopy head waving bouts, day 3	0.2	0.2	0.3	-0.5	0.5	0.5	0.3	-0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.4	0.1	-0.2	-0.2	0.3	-0.7
Locomotion velocity, session 7	0.6	0.7	1.6	-1.3	0.7	0.7	0.9	-0.1
Locomotion distance, session 7	0.7	0.8	2.5	-1.6	0.8	0.8	0.6	0.3
Stereotopy head waving bouts, day 7	1.3	1.4	2.1	1.1	-1.4	-1.4	-1.3	0.1
Stereotopy head waving duration, day 7	0.3	0.3	0.5	0.7	-0.7	-0.7	-0.5	-0.4
Locomotion velocity, session 8	2.1	2.5	5.1	-1.1	1.6	1.6	1.0	-2.2
Locomotion distance, session 8	1.3	1.8	3.7	-1.9	1.6	1.7	0.3	0.2
Degree of sensitization distance	0.5	0.5	0.8	0.8	-0.9	-0.8	-0.3	-0.3
Degree of sensitization stereotypy	1.3	1.5	2.6	1.2	-1.3	-1.3	-1.6	0.1
Conditioned locomotion	0.2	0.2	0.4	0.1	-0.6	-0.6	-0.3	0.4
Cocaine response after cond. corrected	1.7	1.9	3.5	-1.9	1.4	1.4	1.0	1.0
Cocaine response after cond. not corrected	2.3	2.5	3.7	-1.9	1.8	1.8	1.6	0.4
Cocaine response before conditioning	0.6	0.8	2.1	-0.0	0.7	0.7	0.9	-1.4
Saline control response	0.7	0.9	1.6	-1.0	1.3	1.2	-0.1	0.6
Bone: connectivity density	0.9	1.4	6.3	-0.6	0.1	0.1	-0.4	2.5
Bone: cortical apparent density	1.0	1.3	3.7	-0.7	1.1	1.1	1.9	-0.2
Bone: cortical area	0.3	0.4	1.1	-0.7	0.5	0.5	0.1	1.1
Bone: cortical porosity	1.8	1.9	2.6	1.6	-1.6	-1.6	-1.4	-0.4
Bone: cortical porosity	1.5	1.6	2.2	1.5	-1.4	-1.4	-1.5	-0.2
Bone: cortical thickness	0.4	0.7	0.8	-0.8	0.8	0.8	0.9	0.9
Bone: cortical thickness	2.8	3.2	4.8	-1.9	1.7	1.7	1.4	2.2
Bone: cortical tissue density	1.1	1.4	3.8	-0.7	1.2	1.2	2.0	-0.1
Condit. Reinf. active minus inactive responses	2.2	2.4	4.2	2.1	-1.7	-1.8	-1.0	-0.9
Condit. Reinf. active-inactive response ratio	2.5	2.7	4.8	2.2	-1.9	-1.9	-1.0	-0.8
Condit. Reinf. active responses	0.5	0.6	0.8	0.8	-0.6	-0.7	-0.9	-0.7
Condit. Reinf. inactive responses	1.1	1.3	2.5	-1.6	1.4	1.4	0.1	-0.2
Incentive salience index mean	2.4	2.9	5.2	2.3	-1.6	-1.7	-1.2	-1.4
Condit. Reinf. lever presses	0.7	1.0	1.7	1.3	-0.7	-0.8	-1.2	-0.7
Condit. Reinf. active minus inactive responses	2.1	2.7	4.3	-1.3	2.0	2.1	1.1	-1.4
Condit. Reinf. active-inactive response ratio	1.4	1.5	2.9	-0.9	1.3	1.3	0.5	-1.7
Condit. Reinf. active responses	0.6	0.8	1.4	-0.6	1.2	1.2	0.4	-0.8
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.1	0.2	0.2	0.1	0.6
Condit. Reinf. lever presses	1.5	2.0	3.1	-1.0	1.7	1.8	1.6	-0.1
Condit. Reinf. lever reinforcers received	0.9	1.2	2.3	-0.8	1.5	1.5	0.6	-0.7
Conditioned reinforcement - actives	0.8	0.8	2.4	-1.1	0.5	0.3	0.3	1.5
Conditioned reinforcement - inactives	1.0	1.1	2.0	-1.4	1.0	1.1	0.4	1.2
Conditioned locomotion	0.9	1.1	1.5	-1.2	1.2	1.0	0.4	1.1
Patch foraging indifference point 0 sec	2.7	4.4	6.4	-2.5	1.8	1.8	2.5	1.7
Patch foraging indifference point AUC	0.6	0.7	2.4	1.5	-0.6	-0.6	0.5	-0.7
Delay disc. indifference point, 0s delay	0.4	0.5	2.3	0.0	0.1	0.1	-0.0	-1.5
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.6	0.4	0.5	0.8	0.4
Delay disc. indifference point, 2s delay	0.5	0.5	0.9	-0.6	0.8	0.9	0.1	-0.8
Delay disc. indifference point, 24s delay	0.0	0.0	0.1	0.2	-0.0	0.2	0.1	-0.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.1	-0.6	0.7	0.8	0.8	-1.0
Delay disc. indifference point, 8s delay	0.3	0.3	0.7	-0.1	0.5	0.6	0.9	-0.4
Indifference point function ln k	0.7	1.0	2.4	-1.6	1.1	1.1	-0.0	0.0
Indifference point function log k	0.7	1.0	2.4	-1.6	1.1	1.1	-0.0	0.0
Patch foraging total patch changes 0 sec	3.3	5.4	7.9	-2.8	2.0	2.1	2.7	1.7
Patch foraging total patch changes 12 sec	0.4	0.5	1.3	0.1	-0.0	-0.0	1.1	1.0
Patch foraging total patch changes 18 sec	0.6	0.7	2.1	-0.3	-0.0	0.0	1.1	1.5
Patch foraging total patch changes 24 sec	0.7	0.9	1.9	-0.9	0.7	0.8	1.4	0.8
Patch foraging total patch changes 6 sec	1.1	1.7	4.4	-1.3	0.9	0.8	2.1	1.0
Patch foraging time to switch 0 sec	2.7	4.1	6.5	2.2	-2.5	-2.5	-1.7	0.4
Patch foraging water rate 0 sec	1.7	2.8	4.4	-2.0	2.1	2.0	1.3	0.2
Patch foraging water rate 12 sec	2.5	3.8	7.0	-2.6	2.1	2.0	1.7	0.9
Patch foraging water rate 18 sec	2.6	3.5	6.0	-2.4	2.3	2.2	1.0	0.1
Patch foraging water rate 24 sec	2.8	4.0	7.7	-2.6	1.7	1.5	0.7	2.8
Patch foraging water rate 6 sec	6.9	10.1	16.7	-4.1	4.0	3.8	2.0	-0.0
Seeking ratio, delayed vs. immediate footshock	3.5	4.1	6.4	0.9	-2.1	-2.0	-2.1	2.5
Distance traveled before self-admin	1.3	1.3	2.0	-1.4	1.0	1.1	0.9	1.3
Distance traveled after self-admin	1.0	1.1	1.8	-1.3	1.1	1.1	1.0	0.6
Extensor digitorum longus weight	2.6	10.1	14.1	3.1	-3.7	-3.8	-3.2	1.5
Bone: elastic displacement	0.5	0.6	1.0	1.0	-0.4	-0.4	-0.7	-1.0
Bone: elastic work	0.3	0.4	0.6	0.8	-0.4	-0.4	-0.5	0.7
Bone: endosteal estimation	0.1	0.2	1.1	-0.3	0.0	0.1	-1.1	0.2
Bone: endosteal perimeter	0.4	0.8	2.9	0.0	-0.6	-0.6	-1.7	0.7
Epididymis fat weight	0.4	1.0	3.2	-0.9	0.4	0.5	0.7	1.8
Delta time in closed arm before/after self-admin	5.6	5.4	9.2	2.9	-2.9	-3.0	-1.0	-0.5
Delta time in open arm before/after self-admin	0.5	0.4	0.7	-0.8	0.6	0.6	0.4	0.8
Diff in mean of infusions in LGA sessions	0.5	0.6	1.7	0.8	-0.1	-0.1	-0.7	-1.3
Delay discount exponential model param	0.6	0.6	1.1	0.7	-0.8	-1.0	-0.8	0.5
Extinction: sum of active levers before priming	1.2	1.2	2.0	0.8	-1.0	-0.9	-1.4	1.2
Active lever presses in extinction session 6	0.6	0.6	1.2	0.5	-0.8	-0.7	-0.6	1.1
Bone: final force	0.1	0.2	0.3	-0.6	0.5	0.4	-0.3	0.2
Bone: final moment	0.2	0.3	0.6	-0.8	0.5	0.5	-0.3	0.3
Food consumed during 24 hour testing period	0.9	1.0	1.8	-0.9	1.2	1.1	1.3	-0.2
Glucose	0.2	0.3	0.7	0.3	-0.6	-0.6	-0.3	-0.9
Heart weight	0.7	1.0	1.4	0.9	-1.2	-1.2	-1.1	-0.3
Delay discount hyperbolic model param	0.8	0.8	1.4	0.8	-1.0	-1.2	-0.9	0.5
Intermittent access intake day 1-15 change	0.3	0.3	0.5	-0.7	0.6	0.5	0.1	0.5
Intermittent access intake escalation	0.7	0.7	1.2	-1.1	0.9	0.8	0.3	0.7
Intermittent access intake escalation 2	0.3	0.3	0.9	-0.6	0.2	0.1	-0.1	1.0
Intermitt. access day 1 inactive lever presses	1.1	1.2	1.9	1.4	-1.3	-1.3	-0.5	0.7
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.8	0.4	-1.1	-1.0	-1.4	1.0
Intermitt. access escalation Index	0.4	0.3	0.9	0.3	0.2	0.2	0.7	-0.9
Intermittent access day 1 total infusions	1.2	1.3	2.7	-1.4	1.0	0.9	0.2	1.7
Intermittent access day 15 total infusions	2.1	2.3	4.2	-2.0	1.6	1.5	0.4	1.6
Intermittent access terminal intake (last 3 days)	1.5	1.6	2.8	-1.7	1.3	1.1	0.3	1.6
Intermittent access total infusions	2.3	2.5	4.5	-2.1	1.8	1.6	0.2	1.6
Intermittent access day 1 locomotion	1.4	1.5	2.5	-1.4	1.6	1.5	0.7	0.1
Intermittent access day 15 total locomotion	2.7	2.9	4.5	-2.1	2.1	2.1	0.5	1.0
Intermittent access total locomotion	3.1	3.6	5.7	-2.4	2.4	2.2	0.8	0.9
Intermittent access standard deviation	0.3	0.3	0.9	0.2	-0.3	-0.5	-1.0	-0.6
Left kidney weight	0.6	1.7	3.8	-2.0	1.3	1.2	0.6	1.0
Right kidney weight	0.4	1.2	2.5	-1.6	0.9	0.8	0.1	1.4
Cocaine induced anxiety	0.4	0.4	1.0	-0.6	1.0	0.8	0.5	0.2
Post-drug Anxiety	0.8	0.9	1.7	-1.0	1.3	1.2	0.7	-0.4
Baseline Anxiety	0.9	0.9	3.1	0.5	0.0	0.3	-1.1	-1.8
Tail length	4.1	12.3	17.2	-4.1	4.0	3.9	3.4	-0.9
Length with tail	6.6	24.2	34.7	-5.9	5.7	5.7	4.5	-0.7
Length without tail	4.3	9.5	14.2	-3.7	3.6	3.8	2.5	0.1
Times rat made contact with spout	0.3	0.4	0.8	0.4	-0.8	-0.9	-0.5	-0.1
Lifetime Intake	2.6	2.9	5.1	-2.3	1.8	1.6	0.2	1.9
Liver weight, left	2.1	3.4	5.4	-2.3	1.9	1.9	1.9	1.2
Liver weight, right	0.5	0.8	1.7	-1.0	0.6	0.6	0.9	1.3
Locomotor activity	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.5	-0.1
Locomotor testing distance	0.8	1.3	2.3	1.5	-1.3	-1.4	-0.9	0.0
Locomotor testing rearing	0.3	0.5	1.8	0.3	-0.4	-0.5	-0.5	1.3
Locomotion in novel chamber	2.0	2.4	3.9	1.7	-2.0	-2.0	-1.2	0.0
Locomotion in novel chamber post-restriction	0.2	0.2	0.6	0.1	-0.3	-0.2	-0.8	-0.5
Fecal boli incidents, locomotor time 1	1.7	1.9	2.1	1.5	-1.3	-1.4	-1.4	1.3
Change in fecal boli incidents, locomotor task	0.9	0.9	3.5	-0.9	-0.2	-0.3	-0.3	1.9
Time >=10cm from walls, locomotor time 1	3.1	3.1	8.7	0.6	-1.7	-1.6	-1.1	2.9
Bouts of movement, locomotor time 1	0.7	0.7	1.6	1.1	-0.5	-0.7	0.3	-1.2
Total resting periods, locomotor time 1	0.5	0.5	1.0	1.0	-0.5	-0.6	0.2	-1.0
Rest time, locomotor task time 1	1.5	1.6	2.9	1.5	-1.6	-1.7	0.2	0.8
Distance moved, locomotor task time 1	0.6	0.7	1.7	-1.3	0.8	1.0	-0.3	0.2
Vertical activity count, locomotor time 1	1.2	1.3	2.0	-1.4	1.2	1.4	-0.2	-0.9
Time >=10cm from walls, locomotor time 2	1.8	1.9	4.4	0.5	-1.6	-1.4	-0.7	2.1
Bouts of movement, locomotor time 2	0.2	0.2	0.8	-0.1	-0.2	-0.1	0.9	0.5
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.3	-0.6	-0.4	0.4	0.4
Rest time, locomotor task time 2	2.2	2.6	4.2	2.0	-2.0	-1.9	-1.0	0.2
Distance moved, locomotor task time 2	1.1	1.3	2.5	-1.6	1.2	1.3	0.5	0.7
Vertical activity count, locomotor time 2	1.0	1.1	2.0	-1.3	1.2	1.4	0.7	0.0
Light reinforcement 1	0.8	1.4	2.0	-1.2	1.4	1.4	1.0	-1.0
Light reinforcement 2	0.8	1.1	1.8	1.0	-1.3	-1.2	-1.2	-0.1
Bone: marrow area	0.1	0.2	1.1	-0.3	-0.0	0.0	-1.0	0.2
Bone: maximum diameter	0.5	0.8	2.3	0.3	-0.8	-0.8	-0.8	1.5
Bone: maximum force	0.1	0.1	0.4	0.2	-0.1	-0.1	-0.7	0.2
Bone: maximum moment	0.1	0.1	0.4	-0.0	-0.0	-0.0	-0.6	0.4
Mean time between licks in bursts	2.1	3.0	11.8	1.2	-0.3	-0.3	-1.1	-3.4
Mean num. licks in bursts	1.8	2.1	3.4	-1.8	1.8	1.7	0.6	-0.7
Cd content in liver	0.3	0.3	0.5	-0.7	0.7	0.7	-0.1	-0.0
Co content in liver	0.1	0.2	0.5	-0.3	0.2	0.2	-0.7	-0.3
Cu content in liver	0.2	0.2	0.4	-0.6	0.5	0.5	0.4	-0.3
Fe content in liver	2.2	2.7	4.0	-2.0	1.7	1.7	1.4	1.3
K content in liver	0.5	0.5	0.8	-0.2	0.8	0.7	0.8	-0.9
Mg content in liver	0.2	0.2	0.8	0.3	0.1	0.1	0.2	-0.9
Mn content in liver	0.1	0.1	0.3	-0.0	0.1	0.1	-0.6	-0.5
Na content in liver	0.1	0.1	0.6	-0.2	0.2	0.2	0.8	-0.1
Rb content in liver	1.0	1.2	2.2	-0.9	1.5	1.5	0.9	-0.5
Se content in liver	0.6	0.7	1.4	0.8	-1.2	-1.1	-0.5	-0.2
Sr content in liver	1.4	1.3	2.8	1.7	-1.0	-1.0	-1.0	-0.7
Zn content in liver	0.4	0.4	2.0	0.1	-0.1	-0.1	-0.2	-1.4
Bone: minimum diameter	1.3	2.4	4.1	-2.0	1.7	1.8	0.5	1.2
Time in familiar zone, hab. session 1	2.9	2.7	4.5	-2.1	1.7	1.7	1.8	0.2
Time in novel zone, hab. session 1	2.3	2.3	3.1	1.8	-1.6	-1.6	-1.7	-0.2
Total zone transitions, hab. session 1	0.3	0.4	1.0	0.2	-0.6	-0.6	0.0	1.0
Total locomotion distance, hab. session 1	0.3	0.5	1.3	0.6	-0.6	-0.6	-1.1	-0.0
Locomotion velocity, hab. session 1	0.4	0.5	1.5	0.6	-0.6	-0.6	-1.2	0.3
Time in familiar zone, hab. session 2	1.3	1.3	2.9	-1.7	1.2	1.1	0.6	0.8
Time in novel zone, hab. session 2	1.5	1.5	3.1	1.8	-1.4	-1.4	-0.6	-0.4
Total zone transitions, hab. session 2	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2	-0.0
Total locomotion distance, hab. session 2	0.6	0.8	2.3	0.8	-0.7	-0.7	-1.5	-0.2
Locomotion velocity, hab. session 2	0.3	0.4	1.6	0.5	-0.3	-0.3	-1.3	-0.2
Novel to familiar place preference ratio	0.6	0.6	1.2	0.7	-1.1	-1.1	-0.4	0.3
Novelty place preference	0.4	0.4	0.7	0.5	-0.9	-0.8	-0.3	0.3
Time in novel zone, NPP test	0.3	0.4	0.7	0.5	-0.9	-0.8	-0.3	0.2
Total zone transitions, NPP test	0.5	0.7	1.2	-0.8	1.1	1.1	-0.2	-0.6
Total locomotion distance, NPP test	0.5	0.7	2.6	0.5	-0.2	-0.2	-1.6	-0.8
Locomotion velocity, NPP test	0.3	0.5	1.5	-0.2	0.4	0.4	-1.2	-0.6
Intraocular pressure	2.8	3.9	6.0	1.6	-2.4	-2.5	-1.6	1.5
Delta distance traveled before/after self-admin	0.3	0.3	0.4	-0.6	0.6	0.5	0.5	-0.6
Delta ambulatory time before/after self-admin	0.6	0.7	0.9	-0.8	0.9	0.9	0.6	-0.8
Parametrial fat weight	0.2	0.3	0.8	-0.6	0.2	0.2	0.9	-0.5
Pavlov. Cond. lever latency	0.1	0.2	0.7	-0.1	0.1	0.1	0.4	-0.9
Pavlov. Cond. magazine entry latency	1.8	2.3	4.3	-1.4	2.1	2.0	0.6	-0.8
Pavlov. Cond. change in total contacts	1.4	1.5	2.7	-1.5	1.6	1.5	0.3	-0.5
Pavlov. Cond. index score	0.2	0.3	0.5	-0.3	0.7	0.7	-0.2	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.0	0.3	0.2	-0.4	-0.1
Pavlov. Cond. lever contacts	0.2	0.2	0.6	-0.4	0.4	0.4	-0.2	0.8
Pavlov. Cond. magazine entry number	1.2	1.5	2.8	1.0	-1.7	-1.6	-0.4	1.0
Pavlov. Cond. intertrial magazine entries	2.0	2.5	3.9	1.9	-2.0	-1.9	-0.9	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	-0.5	0.9	0.9	-0.1	-0.4
Pavlov. Cond. response bias	1.3	1.5	2.9	-1.4	1.7	1.6	0.3	0.2
Pavlov. Cond. lever latency	0.8	1.1	2.3	0.5	-1.2	-1.2	-1.5	-0.3
Pavlov. Cond. magazine entry latency	0.8	0.9	2.4	-0.8	0.7	0.8	0.7	1.5
Pavlov. Cond. change in total contacts	2.3	3.1	5.1	-1.3	2.2	2.3	2.0	-0.1
Pavlov. Cond. index score	1.2	1.6	2.4	-1.0	1.5	1.5	1.3	0.7
Pavlov. Cond. latency score	1.4	1.8	2.6	-1.1	1.6	1.6	1.4	0.9
Pavlov. Cond. lever contacts	0.9	1.2	1.9	-0.8	1.2	1.3	1.4	0.5
Pavlov. Cond. magazine entry number	0.6	0.8	1.1	0.7	-1.0	-1.1	-0.9	-0.6
Pavlov. Cond. intertrial magazine entries	1.0	1.3	1.6	-1.1	1.3	1.3	0.9	-1.2
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	2.2	-1.0	1.5	1.5	1.3	0.7
Pavlov. Cond. response bias	0.5	0.7	1.2	-0.6	1.0	1.0	1.1	0.5
Time in closed arm before self-admin	0.6	0.7	1.3	-0.8	1.1	1.1	-0.2	-0.7
Time in closed arm after self-admin	0.8	0.8	1.2	1.1	-0.8	-0.8	0.1	-1.1
Time in open arm before self-admin	0.3	0.4	1.0	0.5	-0.5	-0.5	-1.0	0.2
Time in open arm after self-admin	0.5	0.6	1.6	-0.0	-0.4	-0.4	-1.1	1.3
Bone: periosteal estimation	0.2	0.5	1.3	-0.7	0.3	0.3	-0.6	1.1
Bone: periosteal perimeter	0.2	0.4	0.9	-0.3	-0.1	-0.1	-1.0	0.9
Bone: post-yield work	0.0	0.1	0.1	0.4	-0.2	-0.2	0.2	0.1
Progressive ratio test 1 active lever presses	1.4	1.5	2.5	-1.5	1.1	1.1	0.6	1.6
Progressive ratio test 1 breakpoint	1.2	1.3	2.1	-1.3	1.0	1.0	0.6	1.5
Progressive ratio test 1 inactive lever presses	0.9	1.0	1.4	-1.2	1.2	1.0	0.5	1.0
Progressive ratio test 2 active lever presses	1.4	1.5	5.9	-1.1	0.6	0.5	-0.3	2.4
Progressive ratio test 2 breakpoint	1.4	1.6	6.2	-1.1	0.5	0.4	-0.4	2.5
Progressive ratio test 2 inactive lever presses	0.9	1.1	2.0	-1.4	0.9	0.7	-0.5	1.4
Incentive Sensitization - Responses	0.5	0.5	1.7	-0.8	0.4	0.3	0.3	1.3
Incentive Sensitization - Breakpoint	0.5	0.5	1.7	-0.7	0.3	0.2	0.1	1.3
Sum of active levers in priming session hrs 5-6	0.7	0.6	2.2	0.8	-0.2	-0.2	-0.5	-1.5
Progressive ratio	0.2	0.2	0.5	0.5	-0.1	-0.1	0.5	-0.7
Food seeking constrained by brief footshock	3.0	3.7	8.1	-1.8	1.7	1.9	2.8	-0.9
Seeking ratio, punishment vs. effort	1.1	1.4	1.9	-1.4	1.1	1.3	1.3	-0.7
Retroperitoneal fat weight	0.3	0.9	2.4	-0.3	-0.7	-0.6	-1.0	1.5
Reaction time number correct	7.4	10.7	16.2	-4.0	4.0	3.9	2.3	0.6
Reaction time mean minus median	0.3	0.4	1.3	0.4	0.4	0.4	1.1	-0.2
Reaction time mean minus median AUC	0.2	0.3	0.7	-0.1	0.5	0.5	0.9	-0.1
Reaction time num false alarms	0.5	0.6	1.1	0.7	-0.8	-0.9	-0.1	1.1
Reaction time num false alarms AUC	0.8	1.1	1.4	1.0	-1.2	-1.2	-0.1	1.2
Reaction time trials correct on left	7.4	10.7	16.2	-4.0	4.0	3.9	2.3	0.6
Reaction time trials on left	7.8	11.1	17.0	-4.1	4.1	4.0	2.4	0.6
Reaction time mean	1.1	1.6	3.6	1.9	-1.1	-1.0	-0.6	-1.3
Reaction time mean AUC	0.9	1.2	2.9	1.7	-0.8	-0.7	-0.4	-1.3
Median of all reaction times	2.0	2.7	5.1	2.3	-1.4	-1.4	-1.2	-1.7
Reaction time omissions	1.3	1.8	3.1	-1.1	1.7	1.8	1.3	-0.2
Reaction time false alarm rate	4.3	6.0	9.6	3.0	-3.1	-3.1	-1.1	0.7
Reaction time premature initiation rate	0.8	1.1	1.5	-1.2	1.0	1.0	1.2	-0.8
Reaction time premature initiations	4.7	6.6	10.5	-3.2	3.0	2.9	2.2	-0.3
Std. dev. reaction times	0.2	0.2	0.9	0.6	-0.0	0.0	0.9	0.1
Reaction time trials completed	7.8	11.1	17.0	-4.1	4.1	4.0	2.4	0.6
Reaction time trials AUC	7.0	10.1	15.5	-3.9	3.9	3.8	2.3	0.6
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.7	-0.2	-0.1	-0.7	-0.3
Run reversals in cocaine runway, males	0.4	0.3	0.6	0.3	-0.5	-0.5	-0.8	0.7
Latency to leave start box in cocaine runway	2.3	2.5	4.1	2.0	-1.5	-1.6	-1.2	-1.5
Latency to leave start box in cocaine runway, F	0.6	0.6	1.3	1.1	-0.8	-0.8	-0.7	-0.2
Latency to leave start box in cocaine runway, M	2.5	2.4	3.5	1.8	-1.3	-1.4	-1.3	-1.9
Std. dev. time between licks in bursts	0.8	1.0	2.3	1.5	-0.9	-0.9	-0.7	-0.8
Total sessions with >9 infusions	0.8	0.9	2.6	-1.0	0.6	0.5	0.1	1.6
Short access day 1 total inactive lever presses	0.5	0.5	1.5	-1.2	0.6	0.5	0.4	0.6
Short access day 10 total inactive lever presses	0.4	0.5	1.5	1.2	-0.6	-0.6	-0.1	-0.2
Short access day 1 total infusions	1.7	1.8	2.8	-1.7	1.5	1.3	0.6	1.3
Short access day 10 total infusions	1.5	1.6	3.2	-1.8	1.5	1.3	-0.1	0.9
Short access total infusions	2.1	2.4	3.8	-1.9	1.6	1.4	0.3	1.8
Short access day 1 locomotion	0.1	0.1	0.2	-0.3	0.5	0.4	0.0	0.2
Short access day 10 total locomotion	0.1	0.1	0.3	0.2	0.2	0.2	-0.5	-0.5
Short access total locomotion	1.0	1.0	1.9	-1.0	1.4	1.3	0.6	0.3
One hour access (0.3 mA shock)	1.6	1.9	3.2	-1.7	1.4	1.1	-0.0	1.8
Compulsive drug intake	0.6	0.6	1.0	1.0	-0.9	-0.9	-0.7	-0.1
One hour access (shock baseline)	3.2	3.7	6.6	-2.6	2.2	2.1	1.1	1.3
Social response proportion	0.2	0.2	0.7	0.5	-0.2	-0.4	-0.0	0.9
Social responses	0.8	1.0	1.7	-0.5	1.0	0.8	1.3	1.2
Social time	0.2	0.2	0.5	-0.3	0.7	0.6	-0.1	-0.5
Soleus weight	0.1	0.4	0.6	0.2	-0.7	-0.8	-0.7	0.4
Bone: stiffness	0.1	0.1	0.3	0.1	-0.1	-0.1	-0.5	-0.5
Tibialis anterior weight	1.6	5.5	8.2	2.2	-2.9	-2.8	-1.9	1.7
Time to tail flick, vehicle, before self-admin	3.6	3.7	5.4	-1.6	2.3	2.0	2.2	-1.2
Time to tail flick, vehicle, after self-admin	0.4	0.4	1.6	-0.1	0.3	0.2	1.3	-0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.8	-0.6	0.9	0.8	-0.5	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	1.1	-0.1	-0.0	-0.2	1.0	0.2
Delta time to tail flick, vehicle, before/after SA	2.2	2.2	3.3	1.7	-1.8	-1.7	-1.3	-0.2
Delta time to tail flick, test, before/after SA	0.3	0.2	0.7	0.2	-0.4	-0.5	0.9	0.3
Tibia length	3.6	10.1	14.5	-3.6	3.8	3.8	2.2	-1.9
Ambulatory time before self-admin	0.7	0.7	2.7	-0.7	0.4	0.4	0.4	1.6
Ambulatory time after self-admin	1.0	1.1	1.5	-1.2	1.0	1.1	1.1	0.7
Bone: tissue strength	2.1	2.0	3.2	1.8	-1.6	-1.6	-0.7	-1.2
Total heroin consumption	0.4	0.5	1.2	0.9	-0.5	-0.4	0.2	-1.1
Bone: trabecular number	0.3	0.5	2.0	-0.5	0.1	0.1	-0.4	1.4
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	0.2	0.2	0.1	-0.1
Bone: trabecular thickness	0.9	1.1	1.5	1.0	-1.2	-1.2	-1.2	0.7
Bone: trabecular tissue density	3.0	4.3	5.6	2.4	-2.2	-2.1	-1.4	-2.1
Water consumed over 24 hours	0.9	1.1	1.6	1.0	-1.2	-1.3	-0.4	1.0
Number of responses in last shaping day	0.7	0.8	2.8	-0.1	-0.6	-0.7	-0.4	1.7