Ccnt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Ccnt1	0.06	0.04	4.1e-08	0.06	0.07	0.06	0.06	2.9e-07	1.1e-07	1.1e-06	1.4e-07
2	Brain	mRNA stability	Ccnt1	0.05	0.03	1.0e-06	0.06	0.07	0.06	0.07	1.7e-06	5.5e-07	1.0e-06	9.3e-07
3	pVTA	gene expression	Ccnt1	0.07	0.05	4.3e-07	0.09	0.07	0.07	0.08	1.5e-07	1.3e-06	5.4e-06	9.8e-07
4	Liver	gene expression	Ccnt1	0.04	0.04	9.9e-03	0.01	0.01	0.01	0.01	6.2e-02	3.2e-02	3.5e-02	2.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4
Bone: apparent density	8.8	15.1	17.0	4.1	-4.0	4.0	-3.4
Area under the delay curve	1.0	1.2	1.8	1.0	-0.9	1.1	-1.3
BMI with tail	6.2	21.6	24.7	5.0	-4.9	4.9	-3.7
BMI without tail	1.6	5.0	6.4	2.5	-2.5	2.5	-1.1
Body weight	6.5	28.2	33.2	5.7	-5.6	5.8	-3.9
Weight adjusted by age	2.2	3.4	4.7	2.0	-2.2	2.1	0.6
Bone surface	10.2	18.5	21.2	4.6	-4.5	4.5	-3.5
Bone volume	7.9	14.2	16.2	4.0	-3.9	4.0	-3.1
Breakpoint value in progressive ratio session	0.9	1.1	1.5	1.2	-1.2	1.2	-0.3
Number of licking bursts	0.5	0.9	3.1	-0.4	0.2	-0.3	1.8
Context. condit. distance diff. score	0.3	0.3	0.4	0.6	-0.7	0.6	-0.3
Locomotion velocity, session 1	1.0	1.1	1.4	-1.0	1.0	-1.0	1.2
Locomotion distance, session 1	2.4	3.0	4.4	-2.0	2.1	-1.9	-0.1
Locomotion velocity, session 2	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.2
Locomotion distance, session 2	2.0	2.8	4.0	-1.9	2.0	-2.0	0.2
Locomotion velocity, session 3	3.1	3.5	4.8	-2.1	2.2	-2.1	0.6
Locomotion distance, session 3	4.0	4.3	5.9	-2.4	2.4	-2.3	0.7
Stereotopy head waving bouts, day 3	1.0	1.1	1.7	1.2	-1.3	1.1	0.2
Stereotopy head waving duration, day 3	0.4	0.5	0.7	0.8	-0.9	0.7	0.3
Locomotion velocity, session 7	0.1	0.1	0.2	-0.3	0.3	-0.1	0.5
Locomotion distance, session 7	1.1	1.4	1.6	-1.2	1.2	-1.1	1.2
Stereotopy head waving bouts, day 7	1.3	1.4	2.1	1.3	-1.4	1.3	0.5
Stereotopy head waving duration, day 7	0.9	1.1	1.6	1.2	-1.3	1.1	0.3
Locomotion velocity, session 8	0.1	0.1	0.4	0.1	-0.1	0.2	-0.6
Locomotion distance, session 8	1.0	1.5	2.1	-1.3	1.4	-1.4	-0.2
Degree of sensitization distance	0.5	0.6	0.8	0.8	-0.9	0.9	0.3
Degree of sensitization stereotypy	0.4	0.4	0.7	0.5	-0.6	0.5	0.8
Conditioned locomotion	0.7	0.8	2.9	0.2	-0.3	0.1	1.7
Cocaine response after cond. corrected	1.0	1.2	4.6	-0.1	0.3	-0.0	-2.1
Cocaine response after cond. not corrected	0.9	1.1	1.4	-0.9	1.1	-0.9	-1.2
Cocaine response before conditioning	4.7	5.7	6.8	-2.3	2.2	-2.4	2.6
Saline control response	0.0	0.0	0.0	0.0	0.0	-0.1	0.1
Bone: connectivity density	6.1	9.5	10.2	3.2	-3.0	3.1	-3.0
Bone: cortical apparent density	0.5	0.7	1.9	-0.6	0.5	-0.6	1.4
Bone: cortical area	10.2	15.7	19.2	4.3	-4.3	4.4	-2.4
Bone: cortical porosity	1.3	1.4	1.6	-1.1	1.1	-1.3	1.2
Bone: cortical porosity	1.6	1.7	1.9	-1.2	1.2	-1.4	1.3
Bone: cortical thickness	4.6	7.6	9.6	3.0	-3.0	3.1	-1.8
Bone: cortical thickness	0.3	0.3	0.6	0.6	-0.6	0.8	-0.3
Bone: cortical tissue density	0.6	0.9	2.1	-0.7	0.6	-0.7	1.4
Condit. Reinf. active minus inactive responses	0.2	0.2	0.6	-0.3	0.4	-0.3	-0.8
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.7	0.4	-0.3	0.3	-1.3
Condit. Reinf. active responses	0.5	0.6	0.8	-0.8	0.9	-0.9	-0.1
Condit. Reinf. inactive responses	2.5	3.1	3.4	-1.8	1.8	-1.8	1.5
Incentive salience index mean	0.1	0.2	0.6	0.2	-0.1	0.2	-0.8
Condit. Reinf. lever presses	0.3	0.4	0.5	0.5	-0.5	0.7	-0.6
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	-0.2	0.1	-0.2	0.7
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	-0.6	0.6	-0.6	0.6
Condit. Reinf. active responses	0.3	0.4	0.7	-0.6	0.5	-0.6	0.8
Condit. Reinf. inactive responses	0.7	0.9	1.3	-0.9	0.8	-1.0	1.1
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.0	0.1	0.0
Condit. Reinf. lever reinforcers received	0.5	0.8	0.8	-0.9	0.8	-0.9	0.9
Conditioned reinforcement - actives	0.6	1.0	1.4	-1.2	1.1	-0.8	0.9
Conditioned reinforcement - inactives	2.6	3.8	5.1	-2.3	2.2	-1.9	1.3
Conditioned locomotion	0.5	0.6	2.1	-0.5	0.3	-0.4	1.5
Patch foraging indifference point 0 sec	1.5	2.8	3.6	-1.9	1.9	-1.9	0.7
Patch foraging indifference point AUC	0.9	1.2	1.5	-1.1	1.0	-1.2	1.1
Delay disc. indifference point, 0s delay	0.9	1.0	1.5	1.2	-1.2	1.0	-0.3
Delay disc. indifference point, 16s delay	0.9	1.0	1.3	1.0	-1.1	1.1	-0.7
Delay disc. indifference point, 2s delay	0.9	1.0	1.3	1.1	-1.1	1.1	-0.5
Delay disc. indifference point, 24s delay	1.0	1.1	1.4	1.1	-1.1	1.2	-0.6
Delay disc. indifference point, 4s delay	0.9	0.9	2.7	0.6	-0.5	0.6	-1.6
Delay disc. indifference point, 8s delay	2.5	3.0	4.0	1.6	-1.5	1.7	-2.0
Indifference point function ln k	2.2	3.9	5.3	2.3	-2.3	2.1	-0.8
Indifference point function log k	2.2	3.9	5.3	2.3	-2.3	2.1	-0.8
Patch foraging total patch changes 0 sec	1.5	2.8	3.6	-1.9	1.8	-1.9	0.9
Patch foraging total patch changes 12 sec	1.9	2.4	3.0	-1.7	1.6	-1.7	1.2
Patch foraging total patch changes 18 sec	3.5	5.4	6.2	-2.4	2.3	-2.5	2.1
Patch foraging total patch changes 24 sec	1.5	2.6	3.0	-1.6	1.5	-1.6	1.7
Patch foraging total patch changes 6 sec	2.0	3.0	4.0	-2.0	2.0	-1.9	0.8
Patch foraging time to switch 0 sec	1.5	3.1	3.9	-2.0	1.9	-1.7	1.3
Patch foraging water rate 0 sec	2.3	4.8	6.2	2.5	-2.5	2.3	-1.3
Patch foraging water rate 12 sec	2.0	4.2	5.6	2.4	-2.4	2.2	-0.9
Patch foraging water rate 18 sec	0.3	0.5	0.7	0.7	-0.8	0.8	-0.4
Patch foraging water rate 24 sec	2.4	3.3	4.8	2.1	-2.2	2.0	-0.2
Patch foraging water rate 6 sec	3.5	5.1	6.8	2.6	-2.6	2.5	-0.9
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	3.2	0.4	-0.2	0.5	-1.8
Distance traveled before self-admin	0.8	1.1	2.0	-0.9	0.8	-1.0	1.4
Distance traveled after self-admin	0.2	0.3	0.4	-0.5	0.6	-0.7	0.1
Extensor digitorum longus weight	4.0	15.6	19.9	4.2	-4.4	4.5	-2.3
Bone: elastic displacement	4.2	4.9	5.6	-2.4	2.4	-2.4	1.6
Bone: elastic work	0.0	0.0	0.1	-0.1	0.1	-0.1	0.4
Bone: endosteal estimation	6.1	13.4	17.3	4.2	-4.1	4.0	-1.9
Bone: endosteal perimeter	6.2	13.2	16.1	4.0	-4.0	3.9	-2.3
Epididymis fat weight	0.7	2.4	2.8	1.7	-1.6	1.7	-1.1
Delta time in closed arm before/after self-admin	0.3	0.2	0.8	-0.2	0.3	-0.1	-0.9
Delta time in open arm before/after self-admin	1.2	1.1	2.0	-1.0	0.9	-0.9	1.4
Diff in mean of infusions in LGA sessions	1.1	1.3	1.8	1.1	-1.0	1.3	-1.2
Delay discount exponential model param	1.0	1.1	1.7	-0.9	0.9	-1.0	1.3
Extinction: sum of active levers before priming	1.1	1.2	1.8	1.3	-1.3	1.1	0.0
Active lever presses in extinction session 6	1.0	1.0	1.2	1.1	-1.0	1.1	-0.8
Bone: final force	9.7	15.4	17.9	4.2	-4.1	4.2	-3.0
Bone: final moment	10.1	16.2	18.9	4.4	-4.2	4.3	-3.1
Food consumed during 24 hour testing period	1.7	2.3	3.7	1.4	-1.3	1.4	-1.9
Glucose	0.3	0.4	0.5	0.6	-0.7	0.7	0.6
Heart weight	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4
Delay discount hyperbolic model param	1.0	1.1	1.8	-0.9	0.8	-1.0	1.4
Intermittent access intake day 1-15 change	0.1	0.2	0.7	-0.2	0.3	0.0	-0.8
Intermittent access intake escalation	0.1	0.3	1.0	0.0	0.0	0.2	-1.0
Intermittent access intake escalation 2	0.2	0.2	0.8	-0.3	0.3	-0.0	-0.9
Intermitt. access day 1 inactive lever presses	0.9	3.6	9.6	-1.2	1.0	-1.5	3.1
Intermitt. access day 15 inactive lever presses	0.8	1.6	1.9	-1.2	1.2	-1.4	1.2
Intermitt. access escalation Index	0.4	0.5	0.7	0.8	-0.9	0.8	-0.2
Intermittent access day 1 total infusions	0.6	0.9	1.3	-1.1	1.1	-1.0	0.5
Intermittent access day 15 total infusions	0.4	0.5	0.8	-0.9	0.9	-0.7	0.3
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.4	-1.2	1.1	-0.9	0.4
Intermittent access total infusions	1.0	1.2	1.7	-1.3	1.2	-1.0	0.7
Intermittent access day 1 locomotion	0.4	0.5	1.8	-0.3	0.2	-0.3	1.3
Intermittent access day 15 total locomotion	0.3	0.5	1.8	-0.4	0.2	-0.1	1.4
Intermittent access total locomotion	1.5	1.8	4.1	-1.1	0.9	-1.0	2.0
Intermittent access standard deviation	0.1	0.2	0.4	-0.6	0.6	-0.3	-0.2
Left kidney weight	1.5	6.8	14.1	2.1	-1.9	2.2	-3.8
Right kidney weight	4.2	18.9	21.4	4.5	-4.5	4.6	-3.7
Cocaine induced anxiety	2.5	3.5	4.6	2.0	-2.1	2.2	-0.9
Post-drug Anxiety	2.9	3.1	3.6	1.9	-1.9	1.9	-1.3
Baseline Anxiety	0.1	0.1	0.2	0.2	-0.1	0.0	-0.5
Tail length	0.0	0.0	0.1	0.2	-0.3	0.2	0.1
Length with tail	1.6	6.9	8.3	2.8	-2.8	2.9	-1.9
Length without tail	6.0	19.2	20.3	4.4	-4.2	4.5	-4.4
Times rat made contact with spout	0.1	0.1	0.4	-0.1	0.2	-0.0	-0.6
Lifetime Intake	1.2	1.5	2.1	-1.5	1.4	-1.1	0.8
Liver weight, left	9.0	14.9	18.1	4.2	-4.1	4.3	-2.6
Liver weight, right	2.0	3.5	4.6	2.1	-2.1	2.0	-1.0
Locomotor activity	1.0	1.6	1.9	-1.3	1.2	-1.2	1.4
Locomotor testing distance	2.4	4.3	4.7	-2.1	2.0	-2.0	2.2
Locomotor testing rearing	2.1	4.2	6.4	-1.9	1.8	-1.9	2.5
Locomotion in novel chamber	1.0	1.3	1.9	1.3	-1.4	1.2	-0.1
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	-0.1	0.1	0.1	0.1
Fecal boli incidents, locomotor time 1	1.2	1.8	2.3	-1.4	1.5	-1.0	-1.4
Change in fecal boli incidents, locomotor task	0.5	0.5	0.7	0.8	-0.8	0.8	0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.3	0.3	-0.3	0.4	-1.2
Bouts of movement, locomotor time 1	0.3	0.3	1.1	0.1	-0.1	0.4	-1.1
Total resting periods, locomotor time 1	0.2	0.3	0.7	-0.4	0.5	-0.1	-0.8
Rest time, locomotor task time 1	0.3	0.3	0.9	-0.4	0.5	-0.1	-0.9
Distance moved, locomotor task time 1	0.1	0.2	0.6	-0.0	-0.0	-0.2	0.8
Vertical activity count, locomotor time 1	0.7	1.7	2.3	1.2	-1.2	1.3	-1.5
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.7	-0.8	0.8	-0.5	0.3
Bouts of movement, locomotor time 2	1.8	2.9	4.2	1.9	-2.0	2.1	-0.4
Total resting periods, locomotor time 2	1.8	3.2	4.4	2.0	-2.1	2.1	-0.4
Rest time, locomotor task time 2	0.2	0.3	0.7	0.2	-0.2	0.5	-0.8
Distance moved, locomotor task time 2	0.3	0.3	0.6	-0.4	0.4	-0.6	0.8
Vertical activity count, locomotor time 2	0.0	0.1	0.1	0.3	-0.3	0.2	0.1
Light reinforcement 1	2.3	5.6	7.5	-2.3	2.1	-2.2	2.7
Light reinforcement 2	0.5	0.8	1.1	-1.0	1.0	-0.8	0.5
Bone: marrow area	5.9	12.9	16.7	4.1	-4.1	3.9	-1.8
Bone: maximum diameter	4.0	7.4	9.4	3.0	-3.0	3.1	-1.4
Bone: maximum force	12.6	22.4	27.6	5.3	-5.2	5.1	-3.0
Bone: maximum moment	13.1	22.9	28.3	5.3	-5.2	5.1	-3.2
Mean time between licks in bursts	0.1	0.3	0.4	-0.6	0.6	-0.6	0.3
Mean num. licks in bursts	0.7	1.1	4.1	-0.1	0.3	-0.1	-2.0
Cd content in liver	0.6	0.7	1.0	-0.9	1.0	-0.9	-0.3
Co content in liver	0.1	0.1	0.2	-0.1	0.1	0.2	-0.5
Cu content in liver	1.8	2.2	2.7	1.4	-1.3	1.6	-1.6
Fe content in liver	1.2	1.5	2.0	-1.4	1.4	-1.3	0.7
K content in liver	0.2	0.2	0.3	0.3	-0.4	0.5	-0.3
Mg content in liver	0.1	0.1	0.1	-0.2	0.2	-0.1	-0.4
Mn content in liver	0.2	0.2	0.9	-0.1	0.1	-0.2	0.9
Na content in liver	0.2	0.2	0.9	-0.1	-0.1	0.1	0.9
Rb content in liver	0.1	0.1	0.2	0.1	-0.2	0.4	-0.4
Se content in liver	0.9	1.1	1.5	-1.2	1.2	-1.1	0.4
Sr content in liver	1.6	1.4	1.8	1.3	-1.4	1.3	-0.5
Zn content in liver	0.7	0.8	1.1	-0.9	0.8	-0.8	1.1
Bone: minimum diameter	8.0	14.6	18.4	4.3	-4.3	4.2	-2.0
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.5	0.6	-0.6	-0.5
Time in novel zone, hab. session 1	0.5	0.5	0.9	0.5	-0.7	0.5	0.9
Total zone transitions, hab. session 1	0.3	0.4	0.5	-0.7	0.6	-0.7	0.4
Total locomotion distance, hab. session 1	0.0	0.0	0.2	-0.0	0.1	-0.1	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.3
Time in familiar zone, hab. session 2	0.4	0.5	1.3	0.5	-0.4	0.4	-1.2
Time in novel zone, hab. session 2	1.0	1.0	3.5	-0.4	0.3	-0.4	1.9
Total zone transitions, hab. session 2	0.2	0.3	0.4	-0.6	0.6	-0.5	-0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.4	0.5	-0.4	-0.5
Locomotion velocity, hab. session 2	0.1	0.2	0.6	-0.2	0.3	-0.2	-0.8
Novel to familiar place preference ratio	1.5	1.7	2.3	1.4	-1.5	1.4	0.6
Novelty place preference	1.2	1.3	1.7	1.2	-1.3	1.2	0.8
Time in novel zone, NPP test	1.2	1.2	1.5	1.1	-1.2	1.1	1.1
Total zone transitions, NPP test	0.9	1.3	1.9	-1.3	1.4	-1.2	-0.5
Total locomotion distance, NPP test	1.4	1.9	2.7	-1.6	1.6	-1.6	0.1
Locomotion velocity, NPP test	0.7	1.0	1.5	-1.1	1.2	-1.1	-0.4
Intraocular pressure	6.4	9.2	10.8	-3.2	3.2	-3.3	2.4
Delta distance traveled before/after self-admin	0.2	0.2	0.9	0.0	0.1	0.0	-1.0
Delta ambulatory time before/after self-admin	0.0	0.1	0.2	-0.1	0.2	-0.1	-0.4
Parametrial fat weight	0.6	1.3	1.9	-1.4	1.3	-1.1	0.6
Pavlov. Cond. lever latency	0.1	0.2	0.6	0.1	-0.0	-0.2	0.8
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	-0.2	0.3	-0.2	-0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.3	-0.3	0.3	-0.4
Pavlov. Cond. index score	0.3	0.3	0.7	0.3	-0.4	0.6	-0.9
Pavlov. Cond. latency score	0.3	0.3	0.8	0.3	-0.3	0.5	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.5	0.4	-0.3	-0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.7	-0.0	-0.0	-0.1	0.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.5	-0.7	0.7	-0.7	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	0.6	-0.6	0.8	-1.1
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.3	0.3	-0.2	-0.8
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.3	-0.3	0.1	0.1
Pavlov. Cond. magazine entry latency	0.7	0.9	1.2	1.1	-1.1	1.0	-0.4
Pavlov. Cond. change in total contacts	1.7	2.7	3.2	1.7	-1.6	1.8	-1.5
Pavlov. Cond. index score	0.6	0.8	1.1	1.0	-1.0	1.0	-0.6
Pavlov. Cond. latency score	0.6	0.7	0.9	0.9	-0.9	1.0	-0.6
Pavlov. Cond. lever contacts	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3
Pavlov. Cond. magazine entry number	2.1	2.5	3.3	-1.8	1.8	-1.8	0.6
Pavlov. Cond. intertrial magazine entries	4.5	6.8	8.8	-2.9	3.0	-2.9	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.1	1.4	1.1	-1.1	1.2	-0.6
Pavlov. Cond. response bias	0.1	0.1	0.2	0.3	-0.3	0.4	-0.3
Time in closed arm before self-admin	1.8	2.3	3.2	1.7	-1.8	1.6	-0.7
Time in closed arm after self-admin	0.1	0.1	0.2	0.3	-0.3	0.2	-0.5
Time in open arm before self-admin	0.0	0.0	0.1	-0.2	0.1	-0.1	0.3
Time in open arm after self-admin	0.2	0.3	1.0	-0.1	0.1	-0.1	1.0
Bone: periosteal estimation	11.1	23.5	29.0	5.4	-5.4	5.3	-2.8
Bone: periosteal perimeter	10.4	17.9	20.3	4.5	-4.4	4.5	-3.4
Bone: post-yield work	6.4	9.4	12.6	3.5	-3.6	3.3	-1.4
Progressive ratio test 1 active lever presses	4.4	5.5	6.6	-2.4	2.2	-2.1	2.6
Progressive ratio test 1 breakpoint	4.1	5.0	6.2	-2.3	2.1	-2.0	2.5
Progressive ratio test 1 inactive lever presses	1.8	2.6	3.4	-1.6	1.4	-1.5	1.8
Progressive ratio test 2 active lever presses	1.7	2.0	4.0	-1.3	1.1	-1.0	2.0
Progressive ratio test 2 breakpoint	1.7	2.0	4.1	-1.3	1.1	-1.0	2.0
Progressive ratio test 2 inactive lever presses	1.1	1.8	3.1	-1.3	1.1	-1.1	1.8
Incentive Sensitization - Responses	0.2	0.3	0.5	0.5	-0.6	0.7	-0.0
Incentive Sensitization - Breakpoint	0.2	0.2	0.4	0.4	-0.5	0.7	0.1
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1
Progressive ratio	0.2	0.3	0.4	-0.5	0.6	-0.7	-0.2
Food seeking constrained by brief footshock	0.4	0.5	0.7	-0.8	0.8	-0.8	-0.3
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	0.0	0.1	-0.1
Retroperitoneal fat weight	0.2	0.7	1.1	-1.1	1.1	-0.8	0.0
Reaction time number correct	0.5	1.0	1.5	1.2	-1.2	1.0	-0.5
Reaction time mean minus median	3.5	8.8	12.3	-3.4	3.5	-3.3	0.8
Reaction time mean minus median AUC	2.5	6.4	8.9	-2.9	3.0	-2.8	0.8
Reaction time num false alarms	1.5	2.2	2.9	-1.5	1.6	-1.7	0.9
Reaction time num false alarms AUC	2.0	3.1	4.2	-1.9	2.0	-2.1	0.7
Reaction time trials correct on left	0.5	1.0	1.5	1.2	-1.2	1.0	-0.5
Reaction time trials on left	0.4	0.7	1.1	1.1	-1.0	0.8	-0.4
Reaction time mean	0.3	0.5	0.8	-0.9	0.9	-0.5	0.0
Reaction time mean AUC	0.2	0.2	0.5	-0.6	0.7	-0.3	-0.2
Median of all reaction times	0.1	0.1	0.3	0.2	-0.2	0.6	-0.4
Reaction time omissions	7.6	11.1	15.2	-3.8	3.9	-3.6	1.2
Reaction time false alarm rate	2.1	2.9	3.8	-1.9	1.9	-1.9	0.8
Reaction time premature initiation rate	4.7	6.4	6.9	-2.6	2.5	-2.5	2.5
Reaction time premature initiations	2.1	3.7	4.8	-1.9	1.8	-1.9	2.2
Std. dev. reaction times	3.6	6.7	9.5	-3.0	3.1	-2.7	0.8
Reaction time trials completed	0.4	0.7	1.1	1.1	-1.0	0.8	-0.4
Reaction time trials AUC	0.7	1.3	2.0	1.4	-1.3	1.1	-0.6
Run reversals in cocaine runway, females	0.1	0.1	0.4	-0.0	0.0	-0.2	0.7
Run reversals in cocaine runway, males	1.0	1.0	1.2	-1.1	1.1	-1.0	0.7
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.2	0.1	-0.1	0.5
Latency to leave start box in cocaine runway, F	1.2	1.4	2.2	-1.1	1.0	-1.1	1.5
Latency to leave start box in cocaine runway, M	1.5	1.4	1.7	1.3	-1.2	1.3	-0.9
Std. dev. time between licks in bursts	0.8	1.1	1.5	-1.0	0.9	-1.0	1.2
Total sessions with >9 infusions	0.9	1.1	1.7	-1.3	1.2	-0.9	0.3
Short access day 1 total inactive lever presses	1.2	1.5	1.9	-1.4	1.3	-1.3	0.8
Short access day 10 total inactive lever presses	0.2	0.4	0.8	-0.5	0.5	-0.5	0.9
Short access day 1 total infusions	0.2	0.3	0.5	-0.7	0.7	-0.4	-0.3
Short access day 10 total infusions	0.6	0.8	1.3	-1.2	1.1	-0.7	0.3
Short access total infusions	1.2	1.6	2.2	-1.5	1.4	-1.2	0.9
Short access day 1 locomotion	0.1	0.1	0.4	-0.2	0.1	-0.1	0.6
Short access day 10 total locomotion	0.7	1.3	4.5	-0.6	0.4	-0.5	2.1
Short access total locomotion	1.1	1.3	3.4	-0.9	0.7	-0.7	1.8
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	0.2	0.1	-0.2
Compulsive drug intake	0.1	0.1	0.3	-0.1	0.2	-0.4	-0.5
One hour access (shock baseline)	0.1	0.1	0.3	0.2	-0.2	0.6	-0.4
Social response proportion	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.2
Social responses	6.7	8.6	10.9	-3.1	3.0	-3.3	2.1
Social time	0.4	0.6	2.2	-0.0	0.2	-0.0	-1.5
Soleus weight	0.5	1.4	1.8	1.3	-1.3	1.3	-0.7
Bone: stiffness	15.3	24.8	30.1	5.5	-5.4	5.4	-3.3
Tibialis anterior weight	1.1	3.8	5.8	2.0	-2.3	2.4	-0.3
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.5	-1.5	1.5	-1.6	0.9
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	0.3	-0.3	0.2	0.5
Time to tail flick, test, before self-admin	0.3	0.3	0.4	-0.6	0.7	-0.6	-0.2
Time to tail flick, test, after self-admin	0.7	0.7	1.2	0.8	-0.7	0.7	-1.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.6	0.7	0.8	-0.8	0.8	-0.7
Delta time to tail flick, test, before/after SA	0.2	0.2	0.3	0.6	-0.6	0.4	-0.3
Tibia length	6.6	18.2	22.5	4.7	-4.7	4.7	-2.5
Ambulatory time before self-admin	1.8	2.7	3.3	-1.6	1.5	-1.6	1.8
Ambulatory time after self-admin	1.1	1.3	1.7	-1.1	1.1	-1.1	1.3
Bone: tissue strength	0.5	0.5	0.8	0.9	-0.9	0.7	-0.2
Total heroin consumption	1.0	1.2	1.4	1.0	-1.2	1.1	1.0
Bone: trabecular number	5.8	9.5	11.3	3.1	-2.9	2.9	-3.4
Bone: trabecular spacing	2.6	3.5	6.6	-1.7	1.5	-1.5	2.6
Bone: trabecular thickness	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.4
Bone: trabecular tissue density	0.4	0.5	2.1	-0.1	0.0	-0.2	1.4
Water consumed over 24 hours	0.1	0.1	0.1	0.3	-0.2	0.2	-0.3
Number of responses in last shaping day	0.4	0.5	1.8	-0.1	-0.1	-0.1	1.4