Ccnt1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	Ccnt1	0.02	0.01	8.4e-03	0.01	0	0	0	2.3e-02	8.7e-02	1.1e-01	1.3e-01
2	PL	gene expression	Ccnt1	0.05	0.04	5.6e-08	0.06	0.06	0.06	0.06	1.0e-06	2.5e-07	4.7e-07	2.9e-07
3	IL	mRNA stability	Ccnt1	0.11	0.09	8.0e-03	0.03	0.04	0.01	0.03	8.0e-02	3.5e-02	1.7e-01	8.5e-02
4	pVTA	gene expression	Ccnt1	0.1	0.07	7.4e-05	0.08	0.11	0.09	0.1	2.9e-04	2.2e-05	9.7e-05	3.5e-05
5	Brain	mRNA stability	Ccnt1	0.06	0.04	1.6e-07	0.07	0.08	0.07	0.07	3.5e-07	1.4e-07	2.2e-07	3.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	10.5	17.5	18.8	4.3	4.3	-4.2	4.2	-3.9
Area under the delay curve	1.1	1.2	1.3	1.0	1.2	-1.2	1.1	-1.0
BMI with tail	4.6	14.8	15.9	3.6	4.0	-4.0	3.9	-3.7
BMI without tail	0.0	0.0	0.1	-0.3	0.2	-0.2	0.2	-0.2
Body weight	6.6	27.6	29.1	4.9	5.4	-5.4	5.3	-5.2
Weight adjusted by age	2.3	2.6	3.3	1.4	1.6	-1.6	1.7	-1.8
Bone surface	12.3	21.6	22.7	4.8	4.7	-4.7	4.7	-4.4
Bone volume	9.2	15.7	16.8	4.1	4.0	-4.0	4.0	-3.7
Breakpoint value in progressive ratio session	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	-0.4
Number of licking bursts	0.2	0.3	0.6	-0.8	-0.5	0.5	-0.4	0.2
Context. condit. distance diff. score	0.3	0.3	0.4	0.5	0.6	-0.6	0.6	-0.6
Locomotion velocity, session 1	1.1	1.2	1.3	-1.1	-1.1	1.1	-1.1	1.0
Locomotion distance, session 1	3.1	3.9	4.7	-1.9	-1.9	1.9	-2.0	2.2
Locomotion velocity, session 2	0.2	0.3	0.4	-0.4	-0.5	0.5	-0.5	0.6
Locomotion distance, session 2	2.4	3.4	4.1	-1.7	-1.8	1.8	-1.9	2.0
Locomotion velocity, session 3	3.9	4.5	4.9	-2.1	-2.1	2.1	-2.1	2.2
Locomotion distance, session 3	5.0	5.5	6.0	-2.2	-2.3	2.3	-2.4	2.4
Stereotopy head waving bouts, day 3	1.3	1.5	1.8	1.3	1.2	-1.2	1.2	-1.3
Stereotopy head waving duration, day 3	0.5	0.6	0.8	0.9	0.7	-0.7	0.8	-0.8
Locomotion velocity, session 7	0.1	0.1	0.1	-0.4	-0.4	0.4	-0.4	0.3
Locomotion distance, session 7	1.4	1.8	1.9	-1.4	-1.3	1.3	-1.3	1.3
Stereotopy head waving bouts, day 7	1.1	1.2	1.6	1.1	1.0	-1.0	1.1	-1.3
Stereotopy head waving duration, day 7	1.3	1.5	2.0	1.2	1.2	-1.2	1.2	-1.4
Locomotion velocity, session 8	0.0	0.0	0.0	-0.0	0.1	-0.1	0.1	-0.1
Locomotion distance, session 8	1.2	1.8	2.2	-1.3	-1.3	1.3	-1.4	1.5
Degree of sensitization distance	0.6	0.6	0.8	0.7	0.8	-0.8	0.8	-0.9
Degree of sensitization stereotypy	0.2	0.2	0.5	0.3	0.4	-0.4	0.5	-0.7
Conditioned locomotion	0.0	0.1	0.2	0.2	0.1	-0.1	0.2	-0.4
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.0	0.1	-0.0	-0.0	0.4
Cocaine response after cond. not corrected	0.7	0.7	1.2	-0.7	-0.7	0.8	-0.8	1.1
Cocaine response before conditioning	3.9	4.7	5.2	-2.0	-2.3	2.3	-2.2	2.1
Saline control response	0.1	0.1	0.2	0.5	0.3	-0.2	0.3	-0.2
Bone: connectivity density	7.4	11.7	12.8	3.6	3.5	-3.5	3.4	-3.1
Bone: cortical apparent density	0.3	0.4	0.5	-0.5	-0.7	0.7	-0.7	0.6
Bone: cortical area	10.4	15.6	16.2	3.8	4.0	-4.0	4.0	-3.9
Bone: cortical porosity	1.1	1.2	1.4	-0.8	-1.2	1.2	-1.1	1.0
Bone: cortical porosity	1.5	1.7	1.9	-1.0	-1.4	1.4	-1.4	1.2
Bone: cortical thickness	4.1	6.7	7.2	2.3	2.7	-2.7	2.7	-2.6
Bone: cortical thickness	0.2	0.2	0.3	0.3	0.5	-0.6	0.5	-0.5
Bone: cortical tissue density	0.4	0.5	0.6	-0.6	-0.8	0.8	-0.8	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	-0.2	0.2	-0.2	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	0.6	0.5	-0.5	0.4	-0.2
Condit. Reinf. active responses	0.5	0.6	0.8	-0.8	-0.8	0.8	-0.8	0.9
Condit. Reinf. inactive responses	2.7	3.2	3.4	-1.9	-1.8	1.8	-1.8	1.7
Incentive salience index mean	0.0	0.1	0.1	0.1	0.3	-0.3	0.3	-0.2
Condit. Reinf. lever presses	0.2	0.3	0.4	0.3	0.6	-0.6	0.6	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	-0.6	-0.6	0.6	-0.6	0.6
Condit. Reinf. active responses	0.2	0.3	0.4	-0.4	-0.6	0.6	-0.6	0.5
Condit. Reinf. inactive responses	0.6	0.8	1.0	-0.8	-1.0	1.0	-0.9	0.8
Condit. Reinf. lever presses	0.0	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1
Condit. Reinf. lever reinforcers received	0.6	0.8	0.9	-0.8	-0.9	0.9	-0.9	0.8
Conditioned reinforcement - actives	1.6	1.6	2.1	-1.5	-1.3	1.2	-1.2	1.2
Conditioned reinforcement - inactives	1.9	2.1	3.0	-1.7	-1.4	1.4	-1.4	1.4
Conditioned locomotion	0.4	0.5	0.8	-0.9	-0.7	0.7	-0.6	0.5
Patch foraging indifference point 0 sec	2.2	3.5	3.9	-2.0	-1.9	1.8	-1.9	1.8
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.5	-0.5	0.5	-0.5	0.4
Delay disc. indifference point, 0s delay	1.3	1.4	1.6	1.1	1.2	-1.2	1.2	-1.3
Delay disc. indifference point, 16s delay	1.1	1.1	1.3	0.8	1.1	-1.1	1.1	-1.1
Delay disc. indifference point, 2s delay	1.4	1.5	1.8	1.4	1.2	-1.2	1.2	-1.2
Delay disc. indifference point, 24s delay	1.5	1.4	1.5	1.1	1.2	-1.2	1.2	-1.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.4	0.6	0.6	-0.6	0.5	-0.3
Delay disc. indifference point, 8s delay	2.9	3.0	3.4	1.5	1.8	-1.8	1.8	-1.6
Indifference point function ln k	3.8	5.2	5.6	2.4	2.3	-2.3	2.3	-2.2
Indifference point function log k	3.8	5.2	5.6	2.4	2.3	-2.3	2.3	-2.2
Patch foraging total patch changes 0 sec	2.1	3.4	3.7	-1.9	-1.9	1.8	-1.8	1.7
Patch foraging total patch changes 12 sec	2.0	2.5	3.3	-1.8	-1.6	1.6	-1.5	1.4
Patch foraging total patch changes 18 sec	4.1	5.3	5.8	-2.3	-2.4	2.4	-2.3	2.1
Patch foraging total patch changes 24 sec	1.9	2.3	2.7	-1.6	-1.6	1.5	-1.5	1.2
Patch foraging total patch changes 6 sec	2.5	3.6	3.9	-2.0	-1.9	1.9	-1.9	1.8
Patch foraging time to switch 0 sec	2.4	3.7	4.0	-1.8	-2.0	2.0	-2.0	1.9
Patch foraging water rate 0 sec	3.3	5.2	5.5	2.1	2.3	-2.3	2.3	-2.3
Patch foraging water rate 12 sec	3.8	5.9	6.2	2.5	2.4	-2.4	2.4	-2.4
Patch foraging water rate 18 sec	0.3	0.4	0.5	0.5	0.7	-0.7	0.7	-0.7
Patch foraging water rate 24 sec	3.2	4.5	5.0	2.2	2.0	-2.1	2.1	-2.2
Patch foraging water rate 6 sec	4.0	5.8	5.8	2.4	2.4	-2.4	2.4	-2.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	0.5	0.7	-0.7	0.6	-0.4
Distance traveled before self-admin	1.1	1.1	1.3	-1.1	-1.1	1.1	-1.1	0.9
Distance traveled after self-admin	0.2	0.2	0.2	-0.4	-0.4	0.4	-0.4	0.5
Extensor digitorum longus weight	4.4	17.3	19.1	3.6	4.2	-4.3	4.3	-4.4
Bone: elastic displacement	4.8	5.4	5.7	-2.2	-2.4	2.4	-2.4	2.3
Bone: elastic work	0.0	0.0	0.0	0.2	-0.1	0.1	-0.1	0.1
Bone: endosteal estimation	7.6	16.5	17.8	4.2	4.0	-4.0	4.0	-4.1
Bone: endosteal perimeter	7.0	14.4	15.0	3.7	3.8	-3.8	3.8	-3.9
Epididymis fat weight	0.2	0.4	0.5	0.7	0.7	-0.7	0.6	-0.5
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	-0.2
Delta time in open arm before/after self-admin	4.3	4.1	4.4	-2.1	-2.1	2.1	-2.0	1.9
Diff in mean of infusions in LGA sessions	1.5	1.6	1.7	1.3	1.3	-1.3	1.3	-1.2
Delay discount exponential model param	1.0	1.0	1.2	-0.9	-1.1	1.1	-1.0	0.9
Extinction: sum of active levers before priming	0.4	0.4	0.5	0.7	0.6	-0.6	0.6	-0.7
Active lever presses in extinction session 6	0.4	0.4	0.5	0.6	0.7	-0.7	0.7	-0.6
Bone: final force	10.4	16.7	17.3	4.1	4.2	-4.2	4.1	-3.9
Bone: final moment	10.7	17.4	18.1	4.3	4.2	-4.2	4.2	-3.9
Food consumed during 24 hour testing period	1.7	2.0	2.3	1.5	1.5	-1.5	1.4	-1.2
Glucose	0.1	0.2	0.3	0.1	0.4	-0.4	0.4	-0.5
Heart weight	0.0	0.0	0.0	0.2	0.2	-0.2	0.2	-0.0
Delay discount hyperbolic model param	0.9	1.0	1.1	-0.9	-1.1	1.1	-1.0	0.9
Intermittent access intake day 1-15 change	1.3	1.3	1.6	-1.3	-1.1	1.1	-1.1	1.2
Intermittent access intake escalation	0.9	0.9	1.1	-1.1	-0.8	0.9	-0.9	1.0
Intermittent access intake escalation 2	1.4	1.4	1.8	-1.4	-1.1	1.1	-1.1	1.2
Intermitt. access day 1 inactive lever presses	3.2	3.4	4.1	-1.6	-2.0	2.0	-1.9	1.7
Intermitt. access day 15 inactive lever presses	1.3	1.4	1.5	-1.2	-1.2	1.2	-1.2	1.1
Intermitt. access escalation Index	0.2	0.2	0.3	-0.3	-0.5	0.5	-0.5	0.4
Intermittent access day 1 total infusions	1.2	1.4	1.7	-1.3	-1.2	1.2	-1.2	1.2
Intermittent access day 15 total infusions	2.5	2.8	3.6	-1.9	-1.6	1.6	-1.6	1.6
Intermittent access terminal intake (last 3 days)	2.8	3.1	3.7	-1.9	-1.7	1.7	-1.7	1.7
Intermittent access total infusions	2.5	2.8	3.5	-1.9	-1.6	1.6	-1.6	1.6
Intermittent access day 1 locomotion	0.9	1.0	1.1	-1.0	-1.1	1.0	-1.0	0.8
Intermittent access day 15 total locomotion	1.5	1.6	2.5	-1.6	-1.3	1.2	-1.2	0.9
Intermittent access total locomotion	3.3	3.7	4.7	-2.2	-2.0	2.0	-1.9	1.6
Intermittent access standard deviation	0.5	0.5	0.7	-0.8	-0.7	0.7	-0.7	0.8
Left kidney weight	0.4	1.0	1.4	1.0	1.2	-1.1	1.1	-0.7
Right kidney weight	2.8	7.9	8.3	2.6	2.9	-2.9	2.9	-2.8
Cocaine induced anxiety	1.1	1.3	1.5	1.1	1.1	-1.1	1.1	-1.2
Post-drug Anxiety	4.9	5.5	5.7	2.4	2.3	-2.3	2.3	-2.4
Baseline Anxiety	1.1	1.1	1.3	1.0	1.1	-1.1	1.1	-1.0
Tail length	0.1	0.2	0.3	-0.6	-0.4	0.4	-0.4	0.3
Length with tail	2.0	7.4	7.5	2.7	2.7	-2.7	2.7	-2.7
Length without tail	7.7	16.8	17.6	4.1	4.2	-4.2	4.1	-3.9
Times rat made contact with spout	0.0	0.1	0.2	-0.4	-0.1	0.1	-0.1	0.3
Lifetime Intake	2.2	2.5	3.6	-1.9	-1.5	1.5	-1.5	1.5
Liver weight, left	2.0	3.1	3.3	1.6	1.8	-1.8	1.8	-1.8
Liver weight, right	1.6	2.7	2.9	1.6	1.7	-1.7	1.7	-1.7
Locomotor activity	1.0	1.5	2.0	-1.4	-1.2	1.2	-1.2	1.1
Locomotor testing distance	2.8	4.6	5.0	-2.2	-2.2	2.2	-2.1	2.0
Locomotor testing rearing	2.2	3.4	3.8	-1.9	-1.9	1.9	-1.9	1.6
Locomotion in novel chamber	0.6	0.7	0.8	0.8	0.8	-0.8	0.9	-0.9
Locomotion in novel chamber post-restriction	0.1	0.1	0.1	0.2	0.3	-0.3	0.2	-0.3
Fecal boli incidents, locomotor time 1	1.8	2.0	2.8	-1.6	-1.2	1.2	-1.3	1.7
Change in fecal boli incidents, locomotor task	1.3	1.2	1.6	1.2	1.0	-1.0	1.1	-1.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	0.4	0.6	-0.6	0.5	-0.4
Bouts of movement, locomotor time 1	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	-0.1
Total resting periods, locomotor time 1	0.2	0.2	0.3	-0.6	-0.3	0.3	-0.4	0.5
Rest time, locomotor task time 1	0.3	0.3	0.5	-0.7	-0.4	0.4	-0.5	0.6
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.3	-0.1	0.1	-0.0	-0.0
Vertical activity count, locomotor time 1	1.4	1.4	1.5	1.2	1.2	-1.2	1.2	-1.0
Time >=10cm from walls, locomotor time 2	0.5	0.5	0.7	-0.8	-0.7	0.7	-0.7	0.7
Bouts of movement, locomotor time 2	2.6	2.9	3.3	1.6	1.7	-1.7	1.7	-1.8
Total resting periods, locomotor time 2	3.0	3.2	3.7	1.7	1.8	-1.8	1.8	-1.9
Rest time, locomotor task time 2	0.1	0.1	0.1	0.1	0.3	-0.3	0.3	-0.2
Distance moved, locomotor task time 2	0.1	0.2	0.2	-0.2	-0.5	0.5	-0.4	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.1	0.1	0.2	-0.2	0.2	-0.3
Light reinforcement 1	2.7	5.0	5.6	-2.3	-2.4	2.3	-2.3	1.9
Light reinforcement 2	0.8	1.1	1.4	-1.2	-1.0	1.0	-1.0	1.0
Bone: marrow area	7.4	16.1	17.3	4.2	3.9	-3.9	4.0	-4.0
Bone: maximum diameter	4.2	7.7	8.3	2.5	2.8	-2.8	2.8	-2.9
Bone: maximum force	14.3	24.6	26.4	5.1	5.0	-5.0	4.9	-4.8
Bone: maximum moment	14.6	25.1	27.9	5.3	5.0	-5.0	5.0	-4.8
Mean time between licks in bursts	0.1	0.2	0.2	-0.1	-0.4	0.4	-0.4	0.5
Mean num. licks in bursts	0.0	0.0	0.2	0.1	0.1	-0.0	-0.0	0.4
Cd content in liver	0.5	0.5	0.8	-0.9	-0.7	0.7	-0.7	0.7
Co content in liver	0.3	0.4	1.2	-1.1	-0.4	0.4	-0.4	0.3
Cu content in liver	0.8	1.0	1.2	0.7	1.1	-1.1	1.1	-1.0
Fe content in liver	0.2	0.3	0.6	-0.8	-0.5	0.5	-0.4	0.4
K content in liver	0.3	0.3	0.4	0.3	0.7	-0.7	0.6	-0.6
Mg content in liver	0.0	0.0	0.0	-0.1	0.1	-0.1	0.0	0.0
Mn content in liver	0.0	0.0	0.2	0.4	0.1	-0.1	0.1	-0.2
Na content in liver	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	0.1
Rb content in liver	0.2	0.3	0.6	-0.8	-0.5	0.5	-0.5	0.4
Se content in liver	0.5	0.6	0.7	-0.9	-0.7	0.7	-0.7	0.8
Sr content in liver	0.6	0.5	0.6	0.5	0.7	-0.8	0.8	-0.8
Zn content in liver	1.5	1.6	2.5	-1.6	-1.3	1.2	-1.2	1.0
Bone: minimum diameter	9.2	17.2	17.7	4.1	4.1	-4.1	4.2	-4.2
Time in familiar zone, hab. session 1	0.4	0.3	0.5	-0.5	-0.5	0.5	-0.6	0.7
Time in novel zone, hab. session 1	0.3	0.3	0.6	0.5	0.5	-0.5	0.5	-0.8
Total zone transitions, hab. session 1	0.3	0.5	0.5	-0.7	-0.7	0.7	-0.7	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.2	0.0	-0.0	-0.0	0.1
Locomotion velocity, hab. session 1	0.0	0.0	0.1	0.3	0.1	-0.1	0.1	-0.0
Time in familiar zone, hab. session 2	0.2	0.2	0.3	0.6	0.5	-0.5	0.5	-0.3
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.5	-0.6	0.5	-0.5	0.2
Total zone transitions, hab. session 2	0.3	0.4	0.5	-0.6	-0.5	0.5	-0.6	0.7
Total locomotion distance, hab. session 2	0.1	0.1	0.3	-0.1	-0.3	0.3	-0.4	0.5
Locomotion velocity, hab. session 2	0.0	0.0	0.1	0.1	-0.1	0.1	-0.2	0.3
Novel to familiar place preference ratio	1.8	1.9	2.3	1.3	1.3	-1.3	1.4	-1.5
Novelty place preference	1.3	1.3	1.7	1.1	1.1	-1.1	1.1	-1.3
Time in novel zone, NPP test	1.0	1.1	1.5	1.0	0.9	-1.0	1.0	-1.2
Total zone transitions, NPP test	1.2	1.7	2.1	-1.4	-1.2	1.2	-1.3	1.4
Total locomotion distance, NPP test	1.7	2.3	2.8	-1.3	-1.5	1.5	-1.6	1.7
Locomotion velocity, NPP test	0.9	1.2	1.6	-1.0	-1.1	1.1	-1.1	1.3
Intraocular pressure	7.8	10.9	11.2	-3.3	-3.4	3.4	-3.3	3.2
Delta distance traveled before/after self-admin	0.1	0.1	0.1	0.3	0.3	-0.3	0.3	-0.1
Delta ambulatory time before/after self-admin	0.0	0.0	0.0	0.0	0.2	-0.2	0.1	-0.0
Parametrial fat weight	2.0	4.0	4.5	-2.1	-1.9	1.9	-2.0	2.0
Pavlov. Cond. lever latency	0.0	0.0	0.2	0.4	-0.0	0.0	-0.0	-0.0
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	0.0	0.1	-0.1	0.0	0.1
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.0	0.3	-0.3	0.3	-0.3
Pavlov. Cond. index score	0.1	0.1	0.2	0.0	0.4	-0.4	0.4	-0.4
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.0	0.3	-0.4	0.3	-0.3
Pavlov. Cond. lever contacts	0.3	0.3	0.8	-0.9	-0.5	0.5	-0.5	0.5
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.2	0.0	-0.0	0.0	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.6	-0.6	-0.6	0.7	-0.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.5	0.3	0.7	-0.7	0.7	-0.6
Pavlov. Cond. response bias	0.0	0.0	0.1	-0.3	-0.1	0.1	-0.1	0.3
Pavlov. Cond. lever latency	0.0	0.0	0.0	0.1	0.0	-0.0	0.0	-0.0
Pavlov. Cond. magazine entry latency	1.0	1.1	1.3	1.1	1.0	-1.0	1.1	-1.0
Pavlov. Cond. change in total contacts	1.6	2.2	2.4	1.3	1.5	-1.5	1.5	-1.4
Pavlov. Cond. index score	0.5	0.7	0.7	0.8	0.8	-0.8	0.8	-0.8
Pavlov. Cond. latency score	0.6	0.7	0.8	0.8	0.9	-0.9	0.9	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.3	0.3
Pavlov. Cond. magazine entry number	2.3	2.8	3.0	-1.6	-1.6	1.7	-1.7	1.7
Pavlov. Cond. intertrial magazine entries	4.9	6.4	6.8	-2.6	-2.5	2.5	-2.5	2.5
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	1.2	1.0	1.1	-1.1	1.1	-1.1
Pavlov. Cond. response bias	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	0.0
Time in closed arm before self-admin	1.4	1.6	2.0	1.2	1.2	-1.2	1.3	-1.4
Time in closed arm after self-admin	0.6	0.6	0.7	0.9	0.8	-0.8	0.8	-0.8
Time in open arm before self-admin	0.8	0.8	0.9	0.9	0.9	-0.9	0.9	-0.9
Time in open arm after self-admin	0.2	0.3	0.3	-0.6	-0.5	0.5	-0.5	0.4
Bone: periosteal estimation	12.3	25.3	25.6	5.0	5.0	-5.0	5.1	-5.0
Bone: periosteal perimeter	10.6	17.7	18.2	4.1	4.3	-4.3	4.2	-4.1
Bone: post-yield work	8.0	10.9	12.3	3.5	3.2	-3.2	3.2	-3.4
Progressive ratio test 1 active lever presses	4.2	4.4	5.6	-2.4	-2.1	2.1	-2.1	1.9
Progressive ratio test 1 breakpoint	3.8	4.0	5.3	-2.3	-2.0	2.0	-2.0	1.8
Progressive ratio test 1 inactive lever presses	3.6	3.9	4.7	-2.2	-2.0	2.0	-2.0	1.8
Progressive ratio test 2 active lever presses	2.2	2.3	3.2	-1.8	-1.5	1.5	-1.5	1.3
Progressive ratio test 2 breakpoint	2.8	3.2	4.1	-2.0	-1.8	1.8	-1.7	1.6
Progressive ratio test 2 inactive lever presses	2.7	3.1	3.6	-1.9	-1.8	1.8	-1.8	1.6
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.1	0.2	-0.2	0.2	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.2	0.0	-0.1	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.3	0.3
Progressive ratio	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.2	0.2
Food seeking constrained by brief footshock	0.2	0.3	0.6	-0.8	-0.5	0.4	-0.5	0.5
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.0	-0.1
Retroperitoneal fat weight	0.4	1.2	1.8	-1.3	-0.9	1.0	-1.0	1.2
Reaction time number correct	1.2	1.8	2.8	1.7	1.3	-1.2	1.3	-1.2
Reaction time mean minus median	8.5	11.2	12.3	-3.4	-3.3	3.3	-3.3	3.5
Reaction time mean minus median AUC	6.2	8.1	9.0	-2.8	-2.8	2.8	-2.8	3.0
Reaction time num false alarms	1.8	2.4	2.7	-1.4	-1.6	1.6	-1.6	1.6
Reaction time num false alarms AUC	2.6	3.6	4.2	-1.7	-1.9	1.9	-1.9	2.1
Reaction time trials correct on left	1.2	1.8	2.8	1.7	1.3	-1.2	1.3	-1.2
Reaction time trials on left	0.9	1.3	2.3	1.5	1.1	-1.0	1.1	-1.0
Reaction time mean	0.5	0.8	1.0	-1.0	-0.8	0.8	-0.8	0.9
Reaction time mean AUC	0.3	0.4	0.6	-0.7	-0.5	0.6	-0.6	0.7
Median of all reaction times	0.0	0.0	0.1	0.1	0.3	-0.2	0.2	-0.2
Reaction time omissions	10.1	13.8	14.2	-3.7	-3.7	3.7	-3.7	3.8
Reaction time false alarm rate	2.8	3.8	4.1	-2.0	-1.9	1.9	-1.9	2.0
Reaction time premature initiation rate	6.2	8.3	10.1	-3.2	-2.9	2.9	-2.8	2.6
Reaction time premature initiations	3.0	4.2	4.5	-2.1	-2.1	2.1	-2.0	1.9
Std. dev. reaction times	6.2	8.7	9.4	-3.0	-2.9	2.9	-2.9	3.1
Reaction time trials completed	0.9	1.3	2.3	1.5	1.1	-1.0	1.1	-1.0
Reaction time trials AUC	1.6	2.3	3.5	1.9	1.4	-1.4	1.4	-1.4
Run reversals in cocaine runway, females	0.0	0.0	0.0	-0.1	-0.2	0.2	-0.1	0.1
Run reversals in cocaine runway, males	1.5	1.5	1.5	-1.2	-1.2	1.2	-1.2	1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	0.1
Latency to leave start box in cocaine runway, F	1.8	2.0	2.2	-1.3	-1.5	1.5	-1.4	1.3
Latency to leave start box in cocaine runway, M	2.1	2.0	2.1	1.4	1.5	-1.4	1.4	-1.3
Std. dev. time between licks in bursts	0.9	1.1	1.2	-1.1	-1.1	1.1	-1.0	0.9
Total sessions with >9 infusions	0.6	0.7	1.6	-1.3	-0.7	0.7	-0.7	0.7
Short access day 1 total inactive lever presses	1.3	1.4	2.0	-1.4	-1.2	1.1	-1.1	1.1
Short access day 10 total inactive lever presses	0.3	0.4	0.6	-0.4	-0.7	0.7	-0.7	0.5
Short access day 1 total infusions	0.0	0.0	0.2	-0.4	0.0	-0.0	-0.0	0.0
Short access day 10 total infusions	0.8	0.9	1.6	-1.3	-0.8	0.8	-0.8	0.9
Short access total infusions	0.4	0.4	1.1	-1.0	-0.5	0.5	-0.5	0.5
Short access day 1 locomotion	0.1	0.1	0.3	-0.5	-0.2	0.1	-0.2	0.0
Short access day 10 total locomotion	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.4	0.1
Short access total locomotion	0.4	0.4	0.7	-0.9	-0.6	0.6	-0.6	0.3
One hour access (0.3 mA shock)	0.2	0.3	0.6	-0.8	-0.4	0.4	-0.4	0.4
Compulsive drug intake	0.9	0.9	1.3	1.2	0.9	-0.9	0.9	-0.8
One hour access (shock baseline)	0.1	0.1	0.5	-0.7	-0.2	0.2	-0.2	0.2
Social response proportion	0.1	0.1	0.2	-0.5	-0.3	0.3	-0.3	0.4
Social responses	8.0	10.2	10.7	-3.3	-3.2	3.3	-3.2	3.0
Social time	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.1	0.4
Soleus weight	0.6	1.7	2.0	1.3	1.3	-1.3	1.3	-1.4
Bone: stiffness	17.1	27.1	28.4	5.3	5.2	-5.2	5.2	-5.1
Tibialis anterior weight	1.2	4.0	5.5	1.4	2.0	-2.0	2.1	-2.3
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.4	-0.9	-1.1	1.1	-1.1	1.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.5	0.4	-0.4	0.4	-0.6
Time to tail flick, test, before self-admin	0.4	0.4	0.5	-0.6	-0.6	0.6	-0.6	0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	-0.4
Delta time to tail flick, vehicle, before/after SA	0.5	0.5	0.6	0.6	0.7	-0.7	0.7	-0.8
Delta time to tail flick, test, before/after SA	0.2	0.2	0.2	0.4	0.5	-0.5	0.4	-0.5
Tibia length	7.7	21.8	22.3	4.5	4.7	-4.7	4.7	-4.7
Ambulatory time before self-admin	4.0	4.1	4.4	-2.0	-2.1	2.1	-2.1	1.9
Ambulatory time after self-admin	1.7	1.8	2.0	-1.4	-1.4	1.4	-1.4	1.2
Bone: tissue strength	0.9	0.9	1.4	1.2	0.9	-0.9	0.9	-0.9
Total heroin consumption	2.0	2.3	3.1	1.4	1.4	-1.5	1.5	-1.8
Bone: trabecular number	6.2	9.7	11.9	3.4	3.2	-3.2	3.1	-2.7
Bone: trabecular spacing	2.2	2.9	3.7	-1.9	-1.8	1.7	-1.7	1.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.3	-0.2	0.2	-0.3	0.5
Bone: trabecular tissue density	0.1	0.1	0.1	-0.2	-0.4	0.3	-0.3	0.2
Water consumed over 24 hours	0.0	0.0	0.0	0.2	0.1	-0.1	0.1	0.0
Number of responses in last shaping day	0.1	0.1	0.2	0.0	0.3	-0.3	0.3	-0.5