Hub : Genes

Ccdc66

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Ccdc66	0.07	0.05	5.9e-03	0.01	0.01	0.01	0.01	1.0e-02	4.8e-02	2.6e-02	3.1e-02
2	Eye	intron excision ratio	chr16_2680136_2687161	0.29	0.17	5.7e-03	0.16	0.22	0.18	0.2	2.2e-03	2.4e-04	1.0e-03	5.2e-04
3	Brain	gene expression	Ccdc66	0.03	0.02	1.3e-03	0.03	0.03	0.02	0.03	1.4e-03	3.9e-04	3.1e-03	1.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.8	1.4	2.4	1.5	1.0	0.9
Area under the delay curve	0.1	0.1	0.2	-0.0	0.5	0.1
BMI with tail	1.5	5.2	9.7	3.1	1.4	-2.0
BMI without tail	0.9	2.6	5.6	2.4	0.7	-1.3
Body weight	0.6	2.5	5.1	2.3	0.1	-1.5
Weight adjusted by age	0.4	0.5	1.2	-1.1	-0.6	0.2
Bone surface	0.6	1.2	2.6	1.6	0.8	0.5
Bone volume	0.8	1.5	3.8	1.9	0.8	-0.1
Breakpoint value in progressive ratio session	0.1	0.1	0.2	-0.5	-0.2	-0.4
Number of licking bursts	0.1	0.2	0.3	0.4	0.4	-0.6
Context. condit. distance diff. score	0.1	0.1	0.3	-0.2	0.5	0.0
Locomotion velocity, session 1	2.5	2.7	7.5	-2.7	-0.2	-0.6
Locomotion distance, session 1	2.0	2.5	5.7	-2.4	-1.0	-0.8
Locomotion velocity, session 2	3.6	4.1	8.1	-2.9	-1.9	0.7
Locomotion distance, session 2	1.1	1.6	2.6	-1.6	-1.1	-1.0
Locomotion velocity, session 3	2.0	2.2	4.0	-2.0	0.0	-1.7
Locomotion distance, session 3	3.7	4.1	8.6	0.4	1.8	-2.9
Stereotopy head waving bouts, day 3	0.0	0.1	0.2	-0.0	0.4	-0.0
Stereotopy head waving duration, day 3	0.3	0.4	1.0	-0.2	0.3	1.0
Locomotion velocity, session 7	1.9	2.1	5.3	-1.0	0.0	-2.3
Locomotion distance, session 7	0.9	1.1	2.9	-0.3	0.5	-1.7
Stereotopy head waving bouts, day 7	0.8	0.9	2.0	1.4	-0.4	0.7
Stereotopy head waving duration, day 7	0.8	1.0	1.4	1.1	-0.5	1.2
Locomotion velocity, session 8	4.3	5.1	15.1	-3.9	-0.3	-0.5
Locomotion distance, session 8	1.4	2.0	4.7	-2.2	-0.6	-1.0
Degree of sensitization distance	1.0	1.0	1.6	-0.6	-1.3	1.1
Degree of sensitization stereotypy	1.1	1.2	2.0	0.9	-1.0	1.4
Conditioned locomotion	0.5	0.5	1.1	1.1	0.6	-0.4
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.6	-0.1	0.5
Cocaine response after cond. not corrected	0.4	0.5	0.7	-0.6	-0.5	0.8
Cocaine response before conditioning	0.0	0.1	0.1	-0.4	-0.2	-0.2
Saline control response	1.8	2.4	4.6	2.2	0.4	-1.5
Bone: connectivity density	1.5	2.3	4.9	1.3	0.5	2.2
Bone: cortical apparent density	1.0	1.4	2.7	-1.6	1.2	-0.3
Bone: cortical area	5.4	8.3	18.8	4.3	1.9	-1.6
Bone: cortical porosity	0.7	0.7	1.5	0.7	-1.2	-0.3
Bone: cortical porosity	0.6	0.7	1.5	0.6	-1.2	-0.5
Bone: cortical thickness	2.7	4.5	10.2	3.2	1.4	-1.1
Bone: cortical thickness	1.9	2.2	5.6	2.4	1.0	-0.2
Bone: cortical tissue density	1.3	1.8	3.7	-1.9	1.2	-0.2
Condit. Reinf. active minus inactive responses	1.3	1.4	3.0	0.5	1.7	-1.0
Condit. Reinf. active-inactive response ratio	3.7	3.9	9.2	1.5	3.0	-0.6
Condit. Reinf. active responses	0.3	0.3	0.5	-0.2	0.7	-0.7
Condit. Reinf. inactive responses	1.4	1.8	3.0	-1.5	-1.7	-0.3
Incentive salience index mean	0.7	0.8	1.5	0.6	1.2	-0.7
Condit. Reinf. lever presses	0.1	0.1	0.2	0.4	0.1	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.6	0.5	0.3	-0.8
Condit. Reinf. active-inactive response ratio	0.8	1.0	2.7	1.6	-0.3	-0.2
Condit. Reinf. active responses	0.2	0.3	0.7	0.2	0.5	-0.8
Condit. Reinf. inactive responses	0.6	0.8	2.3	-1.5	0.0	-0.4
Condit. Reinf. lever presses	0.7	0.9	1.0	0.9	1.0	-1.0
Condit. Reinf. lever reinforcers received	0.5	0.7	1.1	0.5	0.8	-1.1
Conditioned reinforcement - actives	0.7	1.2	2.5	0.1	-1.6	1.1
Conditioned reinforcement - inactives	0.9	1.4	3.4	1.8	0.6	-0.5
Conditioned locomotion	0.1	0.1	0.2	0.4	-0.4	-0.3
Patch foraging indifference point 0 sec	1.1	2.1	3.3	-0.3	1.8	-1.7
Patch foraging indifference point AUC	0.2	0.2	0.6	0.0	-0.3	0.8
Delay disc. indifference point, 0s delay	0.3	0.3	0.5	0.7	-0.5	0.4
Delay disc. indifference point, 16s delay	0.3	0.4	0.5	-0.7	0.2	-0.7
Delay disc. indifference point, 2s delay	0.6	0.6	1.6	-0.6	1.3	-0.1
Delay disc. indifference point, 24s delay	0.8	0.9	2.7	-1.6	0.0	0.1
Delay disc. indifference point, 4s delay	0.6	0.6	1.4	0.5	1.2	0.4
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.3	-0.5	0.7
Indifference point function ln k	0.9	1.7	3.3	0.7	1.1	-1.8
Indifference point function log k	0.9	1.7	3.3	0.7	1.1	-1.8
Patch foraging total patch changes 0 sec	1.1	2.1	3.3	-0.3	1.8	-1.7
Patch foraging total patch changes 12 sec	0.3	0.4	1.1	-1.1	-0.0	-0.5
Patch foraging total patch changes 18 sec	0.6	0.9	1.7	-0.0	1.3	-1.0
Patch foraging total patch changes 24 sec	0.1	0.2	0.4	0.3	0.6	0.4
Patch foraging total patch changes 6 sec	0.3	0.5	1.4	-0.0	1.2	-0.3
Patch foraging time to switch 0 sec	1.4	2.8	4.6	-1.4	-1.4	2.1
Patch foraging water rate 0 sec	1.7	3.6	4.3	2.0	2.1	-1.6
Patch foraging water rate 12 sec	1.2	2.5	4.7	0.5	2.2	-1.6
Patch foraging water rate 18 sec	0.2	0.4	0.7	0.9	0.7	-0.0
Patch foraging water rate 24 sec	1.8	2.5	3.9	2.0	1.7	-0.8
Patch foraging water rate 6 sec	2.0	2.9	4.2	1.5	2.1	-1.5
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	1.1	1.0	-1.1	0.7
Distance traveled before self-admin	1.0	1.3	2.4	-0.2	1.6	-1.3
Distance traveled after self-admin	1.5	1.8	3.1	0.8	1.8	-1.3
Extensor digitorum longus weight	1.3	5.2	8.9	-0.6	3.0	-2.5
Bone: elastic displacement	0.6	0.7	1.2	-1.1	0.2	-0.9
Bone: elastic work	0.8	1.1	3.1	1.8	-0.4	-0.1
Bone: endosteal estimation	2.6	5.7	16.8	4.1	0.2	-0.6
Bone: endosteal perimeter	1.5	3.1	8.0	2.8	0.9	-0.7
Epididymis fat weight	0.3	1.2	3.0	0.6	-1.7	0.3
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.5	0.2	-0.3
Diff in mean of infusions in LGA sessions	3.8	4.6	7.0	-2.6	-2.6	0.5
Delay discount exponential model param	0.1	0.1	0.2	0.0	-0.5	-0.3
Extinction: sum of active levers before priming	0.7	0.8	1.2	-0.4	1.0	-1.1
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.3	-0.2	-0.5
Bone: final force	3.7	5.8	17.1	4.1	0.4	-0.5
Bone: final moment	3.4	5.5	16.3	4.0	0.1	-0.5
Food consumed during 24 hour testing period	1.5	2.1	3.5	-0.9	1.4	-1.9
Glucose	0.3	0.5	1.1	0.3	-1.1	0.6
Heart weight	1.1	1.7	3.5	0.0	1.9	-1.2
Delay discount hyperbolic model param	0.1	0.1	0.3	0.0	-0.6	-0.1
Intermittent access intake day 1-15 change	2.1	4.3	6.4	-0.6	-2.5	2.5
Intermittent access intake escalation	2.1	4.3	6.6	-0.5	-2.6	2.4
Intermittent access intake escalation 2	0.9	1.0	1.5	0.0	-1.2	1.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.2	0.4	-0.2
Intermitt. access day 15 inactive lever presses	0.4	0.8	1.5	-1.2	-0.4	0.9
Intermitt. access escalation Index	0.8	1.1	2.9	1.7	0.7	-0.2
Intermittent access day 1 total infusions	0.8	1.2	3.5	0.2	0.4	-1.9
Intermittent access day 15 total infusions	0.5	0.7	1.9	-0.5	-1.4	-0.2
Intermittent access terminal intake (last 3 days)	0.8	1.1	3.0	0.1	-1.7	-0.5
Intermittent access total infusions	0.7	0.8	1.8	0.2	-0.8	-1.3
Intermittent access day 1 locomotion	1.1	1.4	4.2	-0.1	-0.0	-2.1
Intermittent access day 15 total locomotion	0.1	0.2	0.6	0.1	0.1	-0.8
Intermittent access total locomotion	0.5	0.6	1.8	-0.2	-0.3	-1.3
Intermittent access standard deviation	0.2	0.3	0.8	0.5	-0.0	-0.9
Left kidney weight	0.2	1.0	1.9	1.4	-1.0	-0.0
Right kidney weight	0.9	4.1	10.9	3.3	0.2	-1.2
Cocaine induced anxiety	0.8	1.2	2.8	0.7	-1.7	0.4
Post-drug Anxiety	0.8	0.9	1.4	1.0	-1.2	0.3
Baseline Anxiety	0.3	0.3	0.6	-0.6	0.8	-0.2
Tail length	0.1	0.5	1.4	-0.3	-1.2	-0.4
Length with tail	0.4	1.5	4.6	-0.0	-2.1	0.1
Length without tail	0.3	0.8	1.6	1.3	-0.7	-0.7
Times rat made contact with spout	3.0	3.5	7.2	-0.2	1.8	-2.7
Lifetime Intake	0.6	0.8	1.8	0.3	-0.6	-1.3
Liver weight, left	2.3	3.8	5.0	2.2	1.3	-2.2
Liver weight, right	1.0	1.7	2.8	1.4	0.5	-1.7
Locomotor activity	0.8	1.3	1.8	1.2	0.8	-1.3
Locomotor testing distance	0.5	0.9	2.4	1.6	0.4	-0.1
Locomotor testing rearing	0.3	0.7	1.6	1.3	0.6	-0.3
Locomotion in novel chamber	0.2	0.2	0.5	-0.7	0.3	0.1
Locomotion in novel chamber post-restriction	0.5	0.8	1.6	0.3	0.8	1.3
Fecal boli incidents, locomotor time 1	0.6	0.8	1.4	0.6	0.8	-1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	-0.1	-0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	-0.3	0.2
Bouts of movement, locomotor time 1	1.4	1.6	3.6	0.9	-1.9	0.6
Total resting periods, locomotor time 1	1.0	1.1	2.8	0.4	-1.7	0.7
Rest time, locomotor task time 1	1.3	1.6	2.3	1.4	-1.5	0.6
Distance moved, locomotor task time 1	0.1	0.2	0.3	0.0	-0.6	0.5
Vertical activity count, locomotor time 1	0.1	0.2	0.4	0.6	-0.1	-0.2
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.5	0.7	0.6	-0.1
Bouts of movement, locomotor time 2	0.6	0.9	1.9	-0.2	-0.9	1.4
Total resting periods, locomotor time 2	0.5	0.8	1.7	0.3	-0.8	1.3
Rest time, locomotor task time 2	1.3	1.6	2.6	1.6	-0.8	1.2
Distance moved, locomotor task time 2	0.2	0.3	0.6	0.2	-0.8	0.4
Vertical activity count, locomotor time 2	0.8	1.1	1.9	1.1	0.5	-1.4
Light reinforcement 1	1.0	2.4	4.3	-0.9	-2.1	1.5
Light reinforcement 2	0.6	0.9	2.1	-0.5	-1.4	0.7
Bone: marrow area	2.5	5.4	15.8	4.0	0.2	-0.6
Bone: maximum diameter	2.9	5.3	7.5	2.6	2.7	-1.4
Bone: maximum force	4.8	8.4	25.2	5.0	-0.2	-0.2
Bone: maximum moment	4.5	7.9	23.4	4.8	-0.5	-0.3
Mean time between licks in bursts	0.3	0.6	1.6	-1.3	-0.5	0.2
Mean num. licks in bursts	0.5	0.7	1.0	-0.3	1.0	-1.0
Cd content in liver	0.6	0.7	2.0	0.2	0.2	1.4
Co content in liver	0.3	0.4	0.5	-0.6	-0.5	0.7
Cu content in liver	1.1	1.4	2.7	-1.6	0.4	-1.1
Fe content in liver	0.5	0.6	1.2	-1.1	0.2	-0.8
K content in liver	1.5	1.4	3.0	-0.9	-1.7	0.6
Mg content in liver	1.0	1.0	1.7	-0.8	-0.8	1.3
Mn content in liver	0.7	0.8	1.3	-1.2	-0.1	1.0
Na content in liver	1.0	1.1	2.6	-0.7	-1.6	0.4
Rb content in liver	2.4	2.8	4.9	0.3	2.2	-1.8
Se content in liver	0.2	0.3	0.4	-0.6	-0.4	0.5
Sr content in liver	0.5	0.4	0.9	1.0	0.5	-0.1
Zn content in liver	0.2	0.2	0.5	-0.7	0.1	-0.2
Bone: minimum diameter	5.3	9.7	25.7	5.1	0.8	-1.7
Time in familiar zone, hab. session 1	2.7	2.6	5.0	2.2	1.3	-1.1
Time in novel zone, hab. session 1	0.9	0.9	1.4	-1.1	-1.2	0.4
Total zone transitions, hab. session 1	1.0	1.5	2.7	-1.6	-0.8	-1.0
Total locomotion distance, hab. session 1	1.4	1.9	2.9	-1.7	-1.6	-0.6
Locomotion velocity, hab. session 1	1.5	2.1	4.7	-2.2	-1.0	-0.8
Time in familiar zone, hab. session 2	1.4	1.5	3.0	-0.4	1.2	-1.7
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.5	-0.4	0.8
Total zone transitions, hab. session 2	0.8	1.0	1.9	-1.0	-0.1	-1.4
Total locomotion distance, hab. session 2	0.9	1.1	2.2	-1.5	-0.1	-1.1
Locomotion velocity, hab. session 2	0.8	1.1	2.4	-1.6	-0.3	-0.9
Novel to familiar place preference ratio	0.5	0.5	1.1	0.5	-1.0	0.5
Novelty place preference	0.2	0.2	0.7	0.2	-0.8	0.1
Time in novel zone, NPP test	0.2	0.2	0.5	0.3	-0.7	0.3
Total zone transitions, NPP test	1.0	1.5	3.6	-1.9	-0.1	-0.9
Total locomotion distance, NPP test	1.5	2.1	4.8	-2.2	-0.3	-1.1
Locomotion velocity, NPP test	1.7	2.4	6.0	-2.5	-0.6	-1.0
Intraocular pressure	2.0	2.8	7.0	-0.0	2.7	-1.2
Delta distance traveled before/after self-admin	0.3	0.3	0.6	0.6	-0.3	0.8
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.1	-0.3	0.5
Parametrial fat weight	0.6	1.3	3.2	1.8	0.1	0.9
Pavlov. Cond. lever latency	0.0	0.1	0.1	0.0	-0.3	0.3
Pavlov. Cond. magazine entry latency	0.4	0.6	1.1	0.2	1.0	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.4	-0.1	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.3	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.2	0.4	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.5	-0.1	0.0
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	0.3	-0.9	0.7
Pavlov. Cond. intertrial magazine entries	0.7	0.8	1.8	-0.7	-1.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	-0.3	-0.1	-0.0
Pavlov. Cond. response bias	0.3	0.3	0.7	-0.8	0.4	-0.4
Pavlov. Cond. lever latency	0.8	1.0	1.8	0.2	-1.1	1.4
Pavlov. Cond. magazine entry latency	2.1	2.5	5.0	-1.5	2.2	-0.7
Pavlov. Cond. change in total contacts	1.4	2.3	4.0	-0.1	2.0	-1.7
Pavlov. Cond. index score	1.4	1.9	3.3	-1.0	1.8	-1.1
Pavlov. Cond. latency score	2.2	2.9	5.0	-1.1	2.2	-1.6
Pavlov. Cond. lever contacts	0.6	0.8	1.3	-0.4	0.9	-1.2
Pavlov. Cond. magazine entry number	2.0	2.4	4.7	1.4	-2.2	0.8
Pavlov. Cond. intertrial magazine entries	2.9	4.3	6.7	2.4	-2.6	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	3.3	-1.2	1.8	-1.0
Pavlov. Cond. response bias	0.5	0.7	1.0	-0.8	1.0	-0.6
Time in closed arm before self-admin	0.6	0.8	1.7	-0.4	0.7	1.3
Time in closed arm after self-admin	0.8	0.8	1.6	-0.3	0.9	1.3
Time in open arm before self-admin	0.5	0.5	1.4	0.0	-1.2	0.5
Time in open arm after self-admin	0.3	0.3	0.5	0.3	-0.6	-0.7
Bone: periosteal estimation	5.2	10.9	29.0	5.4	1.4	-1.3
Bone: periosteal perimeter	2.8	4.7	10.7	3.3	1.6	-1.0
Bone: post-yield work	1.8	2.7	7.6	2.8	-0.1	0.6
Progressive ratio test 1 active lever presses	0.9	1.1	1.7	0.2	-1.3	-1.3
Progressive ratio test 1 breakpoint	0.9	1.1	1.9	0.1	-1.2	-1.4
Progressive ratio test 1 inactive lever presses	0.4	0.5	0.8	-0.1	-0.9	-0.9
Progressive ratio test 2 active lever presses	0.6	0.7	1.1	-0.4	-1.0	-1.0
Progressive ratio test 2 breakpoint	0.6	0.7	1.1	-0.3	-1.0	-1.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.6	-0.3	-0.2
Incentive Sensitization - Responses	0.4	0.6	1.7	-0.2	0.4	-1.3
Incentive Sensitization - Breakpoint	0.5	0.6	1.8	-0.2	0.3	-1.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	0.5	-0.2	-0.4
Progressive ratio	0.2	0.3	0.6	0.8	-0.3	-0.5
Food seeking constrained by brief footshock	1.1	1.3	2.6	0.7	1.6	-0.9
Seeking ratio, punishment vs. effort	0.2	0.3	0.9	-0.3	0.9	-0.0
Retroperitoneal fat weight	0.7	3.1	8.3	2.9	0.8	-0.7
Reaction time number correct	0.1	0.1	0.3	0.2	-0.5	-0.3
Reaction time mean minus median	0.2	0.4	0.9	0.9	-0.3	0.6
Reaction time mean minus median AUC	0.5	1.3	3.6	1.9	-0.3	0.3
Reaction time num false alarms	0.2	0.3	0.7	-0.8	-0.1	-0.5
Reaction time num false alarms AUC	0.2	0.3	0.8	-0.9	0.1	0.0
Reaction time trials correct on left	0.1	0.1	0.3	0.2	-0.5	-0.3
Reaction time trials on left	0.1	0.2	0.3	0.2	-0.6	-0.3
Reaction time mean	0.6	0.9	1.9	1.4	-0.8	0.2
Reaction time mean AUC	0.6	1.0	1.4	1.2	-1.2	0.4
Median of all reaction times	0.6	0.8	1.5	1.2	-1.0	0.1
Reaction time omissions	0.2	0.3	0.5	0.6	-0.7	0.1
Reaction time false alarm rate	0.2	0.3	0.6	-0.8	0.2	0.4
Reaction time premature initiation rate	0.4	0.5	0.8	0.9	0.7	0.6
Reaction time premature initiations	0.3	0.5	1.2	1.1	0.1	0.4
Std. dev. reaction times	0.5	0.8	1.8	1.3	-0.3	0.8
Reaction time trials completed	0.1	0.2	0.3	0.2	-0.6	-0.3
Reaction time trials AUC	0.1	0.2	0.3	0.6	-0.4	-0.4
Run reversals in cocaine runway, females	0.5	0.5	0.6	0.4	0.8	-0.8
Run reversals in cocaine runway, males	1.6	1.6	3.9	-2.0	0.3	-0.9
Latency to leave start box in cocaine runway	2.2	2.5	4.1	-0.3	-2.0	1.8
Latency to leave start box in cocaine runway, F	2.8	3.2	5.4	-0.7	-2.3	1.9
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	0.4	-0.0	0.0
Std. dev. time between licks in bursts	1.1	1.4	1.9	-0.9	-1.4	1.3
Total sessions with >9 infusions	0.8	0.9	2.1	0.7	-0.4	-1.4
Short access day 1 total inactive lever presses	0.9	1.2	2.0	0.5	1.4	-1.2
Short access day 10 total inactive lever presses	0.4	0.9	2.6	-1.6	0.0	0.3
Short access day 1 total infusions	1.1	1.5	3.1	1.0	0.7	-1.7
Short access day 10 total infusions	0.5	0.6	0.9	-0.9	-0.5	-0.9
Short access total infusions	0.8	1.1	3.2	0.2	-0.1	-1.8
Short access day 1 locomotion	2.7	3.3	6.8	0.3	1.8	-2.6
Short access day 10 total locomotion	0.8	1.4	3.9	-0.0	0.6	-2.0
Short access total locomotion	0.8	1.0	3.0	-0.2	0.2	-1.7
One hour access (0.3 mA shock)	0.2	0.3	0.4	-0.5	-0.6	-0.4
Compulsive drug intake	0.1	0.1	0.3	-0.6	0.2	0.3
One hour access (shock baseline)	0.2	0.3	0.5	0.3	-0.5	-0.7
Social response proportion	2.0	2.2	3.9	-0.2	1.7	-2.0
Social responses	0.4	0.6	1.6	-1.2	0.1	0.3
Social time	0.3	0.5	0.8	-0.7	-0.1	0.9
Soleus weight	1.1	3.1	8.7	3.0	0.8	0.0
Bone: stiffness	3.7	6.1	18.0	4.2	-0.3	0.4
Tibialis anterior weight	0.7	2.4	4.3	2.1	0.8	-1.5
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.4	-0.7	-0.5	-0.4
Time to tail flick, vehicle, after self-admin	1.0	1.4	2.4	-1.6	-0.8	1.0
Time to tail flick, test, before self-admin	0.8	0.8	1.6	0.1	-1.3	0.8
Time to tail flick, test, after self-admin	0.9	1.0	2.4	-0.1	-1.6	0.7
Delta time to tail flick, vehicle, before/after SA	0.7	0.6	1.3	-0.4	-0.6	1.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.1	0.4	-0.8
Tibia length	0.9	2.4	3.0	-1.5	-1.3	1.7
Ambulatory time before self-admin	0.7	1.1	2.4	-0.0	1.5	-1.0
Ambulatory time after self-admin	1.6	1.8	3.6	0.1	1.9	-1.4
Bone: tissue strength	0.4	0.4	1.0	1.0	-0.3	-0.1
Total heroin consumption	0.3	0.3	0.6	-0.5	-0.5	-0.8
Bone: trabecular number	1.2	2.0	4.5	2.1	0.2	1.2
Bone: trabecular spacing	1.3	1.7	4.5	-0.8	-2.1	0.1
Bone: trabecular thickness	0.3	0.4	0.9	0.6	0.9	0.1
Bone: trabecular tissue density	0.0	0.0	0.0	0.2	-0.2	0.2
Water consumed over 24 hours	1.8	2.4	4.9	0.2	2.2	-1.5
Number of responses in last shaping day	0.7	0.7	2.1	-0.3	0.1	-1.5