Hub : Genes

Ccdc66

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	mRNA stability	Ccdc66	0.05	0.04	1.7e-03	0.01	0.01	0.01	0.01	1.7e-02	1.2e-02	1.4e-02	1.1e-02
2	Eye	intron excision ratio	chr16_2673451_2680476	0.32	0.18	3.6e-03	0.18	0.24	0.07	0.22	9.7e-04	1.2e-04	3.0e-02	2.9e-04
3	Brain	gene expression	Ccdc66	0.03	0.02	7.2e-04	0.03	0.03	0.02	0.03	6.3e-04	3.6e-04	5.0e-03	2.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.4	0.7	0.9	0.7	0.8	1.0
Area under the delay curve	0.1	0.1	0.2	-0.1	0.5	0.0
BMI with tail	1.1	3.5	6.9	2.6	1.0	-1.6
BMI without tail	1.2	2.4	6.7	2.6	0.3	-0.7
Body weight	1.0	4.2	11.5	3.4	-0.9	-0.5
Weight adjusted by age	0.5	0.6	1.4	-1.2	-0.5	0.4
Bone surface	0.3	0.6	1.1	1.0	0.8	0.2
Bone volume	0.6	1.0	2.4	1.5	0.7	-0.2
Breakpoint value in progressive ratio session	0.6	0.7	1.4	-1.2	0.4	-0.6
Number of licking bursts	0.2	0.2	0.3	0.4	0.4	-0.5
Context. condit. distance diff. score	0.1	0.1	0.2	-0.5	0.4	0.0
Locomotion velocity, session 1	1.7	1.8	5.2	-2.3	-0.3	-0.4
Locomotion distance, session 1	0.9	1.2	2.2	-1.5	-1.0	-0.6
Locomotion velocity, session 2	2.3	2.7	3.8	-2.0	-1.9	0.9
Locomotion distance, session 2	0.5	0.7	1.1	-0.6	-1.0	-0.8
Locomotion velocity, session 3	1.2	1.4	2.2	-1.4	0.0	-1.5
Locomotion distance, session 3	3.5	3.8	8.1	0.2	1.8	-2.9
Stereotopy head waving bouts, day 3	0.0	0.1	0.1	-0.2	0.3	-0.0
Stereotopy head waving duration, day 3	0.5	0.6	1.0	-0.8	0.3	1.0
Locomotion velocity, session 7	1.4	1.5	4.4	-0.2	0.1	-2.1
Locomotion distance, session 7	0.7	0.9	2.6	-0.0	0.5	-1.6
Stereotopy head waving bouts, day 7	0.8	0.8	1.3	1.1	-0.5	1.0
Stereotopy head waving duration, day 7	0.8	1.0	1.4	1.1	-0.5	1.2
Locomotion velocity, session 8	3.2	3.8	11.3	-3.4	-0.2	-0.3
Locomotion distance, session 8	0.7	1.0	1.9	-1.4	-0.6	-0.9
Degree of sensitization distance	0.9	0.9	1.5	-0.2	-1.2	1.1
Degree of sensitization stereotypy	1.2	1.3	2.0	1.0	-0.9	1.4
Conditioned locomotion	0.3	0.4	1.0	1.0	0.3	-0.0
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.6	-0.1	0.5
Cocaine response after cond. not corrected	0.4	0.5	0.8	-0.6	-0.5	0.9
Cocaine response before conditioning	0.0	0.1	0.1	-0.4	-0.2	-0.1
Saline control response	1.8	2.3	3.3	1.8	0.8	-1.8
Bone: connectivity density	1.1	1.8	5.1	0.3	0.4	2.3
Bone: cortical apparent density	1.8	2.4	4.9	-2.2	1.4	-0.6
Bone: cortical area	4.6	7.0	13.1	3.6	2.0	-2.0
Bone: cortical porosity	1.7	1.9	2.8	1.7	-1.7	-0.1
Bone: cortical porosity	1.4	1.5	2.7	1.6	-1.3	-0.5
Bone: cortical thickness	2.0	3.3	7.1	2.7	1.2	-1.1
Bone: cortical thickness	1.1	1.3	3.3	1.8	0.8	-0.0
Bone: cortical tissue density	2.3	3.0	6.5	-2.5	1.4	-0.6
Condit. Reinf. active minus inactive responses	1.3	1.5	3.1	-0.3	1.8	-1.1
Condit. Reinf. active-inactive response ratio	3.0	3.3	9.2	-0.2	3.0	-0.8
Condit. Reinf. active responses	0.3	0.4	0.5	-0.4	0.7	-0.7
Condit. Reinf. inactive responses	0.8	1.0	2.8	-0.4	-1.7	-0.1
Incentive salience index mean	0.6	0.7	1.5	0.1	1.2	-0.8
Condit. Reinf. lever presses	0.1	0.1	0.1	0.3	0.3	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.4	0.5	0.3	-0.6
Condit. Reinf. active-inactive response ratio	1.1	1.1	3.3	1.8	-0.2	-0.1
Condit. Reinf. active responses	0.2	0.3	0.5	0.1	0.6	-0.7
Condit. Reinf. inactive responses	0.5	0.7	1.9	-1.4	0.0	-0.3
Condit. Reinf. lever presses	0.8	1.1	1.7	0.5	1.1	-1.3
Condit. Reinf. lever reinforcers received	0.3	0.5	0.8	0.2	0.8	-0.9
Conditioned reinforcement - actives	1.4	1.4	2.6	0.4	-1.6	1.1
Conditioned reinforcement - inactives	1.0	1.1	1.7	1.3	1.0	-0.9
Conditioned locomotion	0.3	0.4	0.8	0.5	-0.9	-0.4
Patch foraging indifference point 0 sec	1.6	2.6	3.5	-0.9	1.9	-1.8
Patch foraging indifference point AUC	0.2	0.2	0.4	0.3	-0.4	0.7
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	0.9	-0.4	0.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.3	-0.6	0.1	-0.3
Delay disc. indifference point, 2s delay	0.7	0.8	1.8	-0.7	1.3	-0.3
Delay disc. indifference point, 24s delay	0.8	0.8	2.3	-1.5	0.1	0.3
Delay disc. indifference point, 4s delay	0.5	0.6	1.7	0.2	1.3	-0.1
Delay disc. indifference point, 8s delay	0.4	0.4	1.0	0.1	-0.6	1.0
Indifference point function ln k	0.8	1.1	2.2	0.6	1.0	-1.5
Indifference point function log k	0.8	1.1	2.2	0.6	1.0	-1.5
Patch foraging total patch changes 0 sec	1.6	2.7	3.7	-0.8	1.9	-1.9
Patch foraging total patch changes 12 sec	0.3	0.3	0.8	-0.9	-0.0	-0.5
Patch foraging total patch changes 18 sec	0.9	1.2	2.0	-0.5	1.4	-1.1
Patch foraging total patch changes 24 sec	0.2	0.2	0.6	-0.2	0.8	0.2
Patch foraging total patch changes 6 sec	0.6	0.9	1.8	-0.6	1.3	-0.6
Patch foraging time to switch 0 sec	1.7	2.6	3.9	-1.4	-1.3	2.0
Patch foraging water rate 0 sec	1.7	2.7	4.3	1.2	2.1	-1.6
Patch foraging water rate 12 sec	1.3	2.0	4.2	-0.2	2.0	-1.4
Patch foraging water rate 18 sec	0.1	0.2	0.4	0.3	0.6	0.1
Patch foraging water rate 24 sec	1.0	1.5	2.5	1.1	1.6	-0.8
Patch foraging water rate 6 sec	1.4	2.0	3.5	0.8	1.9	-1.3
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	1.8	1.4	-1.2	0.7
Distance traveled before self-admin	2.1	2.3	3.6	-0.5	1.9	-1.7
Distance traveled after self-admin	0.8	0.9	1.4	0.0	1.2	-1.1
Extensor digitorum longus weight	1.6	6.2	8.8	-1.7	3.0	-2.6
Bone: elastic displacement	0.4	0.5	0.9	-1.0	0.1	-0.7
Bone: elastic work	1.1	1.4	4.1	2.0	-0.5	-0.0
Bone: endosteal estimation	2.7	6.0	16.4	4.1	0.5	-1.1
Bone: endosteal perimeter	1.5	3.1	6.1	2.5	1.3	-1.3
Epididymis fat weight	0.8	1.8	2.3	1.5	-1.5	1.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.2	-0.2	0.1
Delta time in open arm before/after self-admin	0.2	0.2	0.3	0.3	0.3	-0.6
Diff in mean of infusions in LGA sessions	3.1	3.4	6.9	-1.6	-2.6	0.9
Delay discount exponential model param	0.1	0.1	0.2	0.1	-0.5	-0.1
Extinction: sum of active levers before priming	1.3	1.3	1.5	-1.2	1.0	-1.2
Active lever presses in extinction session 6	0.3	0.3	0.7	-0.8	0.1	-0.3
Bone: final force	3.3	5.4	15.4	3.9	0.5	-0.7
Bone: final moment	3.6	5.9	17.1	4.1	0.2	-0.8
Food consumed during 24 hour testing period	1.9	2.3	3.5	-1.2	1.4	-1.9
Glucose	0.8	1.1	2.4	0.9	-1.5	0.5
Heart weight	1.2	1.8	3.2	-1.0	1.8	-1.1
Delay discount hyperbolic model param	0.1	0.1	0.4	0.1	-0.6	-0.1
Intermittent access intake day 1-15 change	3.0	3.0	4.5	0.1	-2.1	2.1
Intermittent access intake escalation	3.5	3.4	5.3	-0.1	-2.3	2.2
Intermittent access intake escalation 2	0.6	0.6	0.9	0.3	-0.9	0.9
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.8	-0.1	0.9	-0.1
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.1	-1.0	-0.5	0.9
Intermitt. access escalation Index	0.4	0.3	0.8	0.9	0.4	-0.0
Intermittent access day 1 total infusions	0.6	0.7	2.0	0.1	0.2	-1.4
Intermittent access day 15 total infusions	0.9	1.0	2.8	-0.3	-1.7	0.3
Intermittent access terminal intake (last 3 days)	1.2	1.3	3.4	0.7	-1.8	-0.2
Intermittent access total infusions	0.6	0.7	1.6	0.5	-1.3	-0.4
Intermittent access day 1 locomotion	1.5	1.5	4.6	0.1	0.1	-2.1
Intermittent access day 15 total locomotion	0.2	0.2	0.5	0.1	-0.3	-0.7
Intermittent access total locomotion	0.4	0.5	0.9	0.2	-0.7	-1.0
Intermittent access standard deviation	0.7	0.7	1.6	1.3	-0.7	0.1
Left kidney weight	0.5	1.4	2.4	1.5	-1.2	0.6
Right kidney weight	1.0	2.7	6.5	2.6	-1.0	-0.7
Cocaine induced anxiety	0.8	0.9	1.4	1.2	-1.1	-0.3
Post-drug Anxiety	0.1	0.2	0.2	0.4	-0.3	-0.5
Baseline Anxiety	0.2	0.2	0.4	-0.6	0.5	-0.3
Tail length	0.2	0.7	1.3	1.1	-0.9	0.1
Length with tail	0.6	2.1	4.4	1.3	-2.1	0.5
Length without tail	0.8	1.6	3.3	1.3	-1.8	-0.1
Times rat made contact with spout	3.3	3.8	7.8	-0.3	1.9	-2.8
Lifetime Intake	0.7	0.7	1.6	0.5	-1.3	-0.6
Liver weight, left	0.6	1.0	2.0	1.4	0.0	-1.0
Liver weight, right	0.6	1.0	1.6	1.2	-0.3	-1.3
Locomotor activity	0.9	1.4	1.9	1.4	0.8	-1.3
Locomotor testing distance	0.5	0.9	2.3	1.5	0.6	-0.2
Locomotor testing rearing	0.3	0.5	1.1	1.1	0.6	-0.3
Locomotion in novel chamber	0.2	0.2	0.6	-0.8	-0.2	-0.2
Locomotion in novel chamber post-restriction	0.5	0.6	0.9	-0.3	1.0	0.9
Fecal boli incidents, locomotor time 1	0.5	0.5	0.9	0.4	0.6	-1.0
Change in fecal boli incidents, locomotor task	0.3	0.2	0.6	0.8	-0.2	-0.3
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.0	0.1	-0.2	0.1
Bouts of movement, locomotor time 1	1.9	2.1	3.3	1.6	-1.8	0.7
Total resting periods, locomotor time 1	1.4	1.6	2.7	1.1	-1.6	0.9
Rest time, locomotor task time 1	1.4	1.6	2.5	1.6	-1.2	0.8
Distance moved, locomotor task time 1	0.2	0.2	0.3	0.3	-0.5	0.4
Vertical activity count, locomotor time 1	0.2	0.2	0.5	0.7	-0.1	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.5	0.9	-0.4
Bouts of movement, locomotor time 2	0.5	0.5	1.0	-0.2	-0.7	1.0
Total resting periods, locomotor time 2	0.4	0.5	0.9	0.3	-0.6	0.9
Rest time, locomotor task time 2	1.6	1.8	3.1	1.8	-0.9	1.3
Distance moved, locomotor task time 2	0.3	0.3	0.5	0.5	-0.7	0.4
Vertical activity count, locomotor time 2	1.1	1.2	2.5	0.8	0.6	-1.6
Light reinforcement 1	1.2	2.3	4.2	-0.2	-2.1	1.6
Light reinforcement 2	0.7	0.9	2.1	-0.0	-1.4	0.8
Bone: marrow area	2.6	5.6	15.5	3.9	0.5	-1.1
Bone: maximum diameter	2.6	4.7	8.8	1.3	3.0	-1.9
Bone: maximum force	5.2	9.0	26.7	5.2	-0.0	-0.7
Bone: maximum moment	5.4	9.4	27.5	5.2	-0.3	-0.7
Mean time between licks in bursts	0.2	0.3	0.4	-0.6	-0.6	0.2
Mean num. licks in bursts	0.7	0.8	1.2	-0.6	1.0	-1.1
Cd content in liver	0.6	0.7	1.1	-1.0	1.0	0.1
Co content in liver	0.2	0.3	0.8	-0.1	0.1	-0.9
Cu content in liver	0.8	0.9	2.1	-0.7	0.3	-1.5
Fe content in liver	0.1	0.1	0.4	-0.6	0.2	-0.0
K content in liver	0.4	0.4	1.2	-0.2	-1.1	0.1
Mg content in liver	0.1	0.1	0.3	-0.5	-0.3	0.1
Mn content in liver	0.7	0.8	2.1	-1.5	0.0	0.6
Na content in liver	1.8	1.9	4.2	-0.0	-2.0	1.2
Rb content in liver	2.8	3.5	5.7	-0.2	2.4	-2.2
Se content in liver	1.1	1.3	2.5	-0.9	-0.7	1.6
Sr content in liver	0.2	0.2	0.2	0.5	0.5	-0.2
Zn content in liver	0.3	0.4	0.6	-0.7	-0.2	-0.8
Bone: minimum diameter	5.3	10.0	24.8	5.0	0.9	-2.1
Time in familiar zone, hab. session 1	2.3	2.1	3.4	1.8	1.2	-1.2
Time in novel zone, hab. session 1	0.7	0.6	1.4	-0.5	-1.2	0.5
Total zone transitions, hab. session 1	0.5	0.7	0.8	-0.9	-0.7	-0.9
Total locomotion distance, hab. session 1	0.7	0.9	2.4	-0.6	-1.5	-0.4
Locomotion velocity, hab. session 1	0.7	1.0	1.7	-1.3	-0.9	-0.6
Time in familiar zone, hab. session 2	1.5	1.6	3.0	-0.5	1.2	-1.7
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.4	-0.4	0.7
Total zone transitions, hab. session 2	0.4	0.6	1.5	-0.5	-0.1	-1.2
Total locomotion distance, hab. session 2	0.5	0.7	1.1	-1.0	-0.1	-1.0
Locomotion velocity, hab. session 2	0.5	0.6	1.2	-1.1	-0.2	-0.8
Novel to familiar place preference ratio	0.7	0.7	1.0	0.9	-1.0	0.5
Novelty place preference	0.3	0.3	0.6	0.6	-0.8	0.1
Time in novel zone, NPP test	0.3	0.3	0.4	0.6	-0.7	0.3
Total zone transitions, NPP test	0.6	0.9	2.1	-1.4	-0.1	-0.8
Total locomotion distance, NPP test	0.9	1.2	2.7	-1.6	-0.2	-1.0
Locomotion velocity, NPP test	1.0	1.3	3.1	-1.8	-0.5	-0.8
Intraocular pressure	2.6	3.6	7.1	-1.4	2.7	-1.3
Delta distance traveled before/after self-admin	0.8	0.8	1.5	0.1	-1.0	1.2
Delta ambulatory time before/after self-admin	0.5	0.6	0.9	-0.1	-0.9	0.9
Parametrial fat weight	0.6	1.1	2.4	1.6	0.1	1.0
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.1	-0.3	0.4
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.1	0.9	-0.6
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.3	-0.0	0.2
Pavlov. Cond. index score	0.0	0.0	0.1	-0.1	0.2	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.2	0.1	0.4	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.3	-0.5	-0.1	0.1
Pavlov. Cond. magazine entry number	0.6	0.7	1.0	0.7	-1.0	0.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.7	-0.1	-1.3	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.2	-0.1	0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	-1.0	0.4	-0.4
Pavlov. Cond. lever latency	1.0	1.4	2.5	0.5	-1.2	1.6
Pavlov. Cond. magazine entry latency	3.6	4.1	6.7	-2.6	2.2	-0.9
Pavlov. Cond. change in total contacts	2.0	2.8	4.2	-1.0	2.0	-1.8
Pavlov. Cond. index score	2.3	3.0	3.7	-1.9	1.9	-1.2
Pavlov. Cond. latency score	3.2	4.0	5.3	-2.0	2.3	-1.7
Pavlov. Cond. lever contacts	0.8	1.1	1.6	-0.7	1.1	-1.3
Pavlov. Cond. magazine entry number	3.4	4.2	5.7	2.4	-2.4	1.2
Pavlov. Cond. intertrial magazine entries	5.4	7.1	13.5	3.7	-2.7	0.8
Pavlov. Cond. lever-magazine prob. diff.	2.6	3.3	4.4	-2.1	2.0	-1.2
Pavlov. Cond. response bias	0.9	1.3	1.9	-1.4	1.1	-0.8
Time in closed arm before self-admin	0.8	0.9	1.8	-0.8	0.7	1.3
Time in closed arm after self-admin	0.8	0.8	1.5	-0.4	0.9	1.2
Time in open arm before self-admin	0.7	0.8	1.7	0.4	-1.3	0.7
Time in open arm after self-admin	0.4	0.5	0.6	0.6	-0.8	-0.7
Bone: periosteal estimation	4.6	9.5	22.8	4.8	1.6	-1.8
Bone: periosteal perimeter	2.5	4.1	6.6	2.6	1.9	-1.5
Bone: post-yield work	1.8	2.4	7.2	2.7	0.1	0.2
Progressive ratio test 1 active lever presses	1.8	1.9	2.5	1.6	-1.5	-1.0
Progressive ratio test 1 breakpoint	2.3	2.4	3.2	1.8	-1.6	-1.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.6	0.7	-0.8	-0.5
Progressive ratio test 2 active lever presses	0.6	0.6	1.4	0.3	-1.2	-0.6
Progressive ratio test 2 breakpoint	0.6	0.7	1.1	0.5	-1.1	-0.8
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.5	0.4	-0.7	0.1
Incentive Sensitization - Responses	0.4	0.4	1.3	0.0	0.1	-1.1
Incentive Sensitization - Breakpoint	0.5	0.5	1.5	0.1	0.0	-1.2
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	0.1	-0.2	-0.2
Progressive ratio	0.3	0.3	0.7	0.8	-0.3	-0.3
Food seeking constrained by brief footshock	0.9	1.1	2.7	0.2	1.6	-0.8
Seeking ratio, punishment vs. effort	0.4	0.5	0.9	-0.8	0.9	-0.0
Retroperitoneal fat weight	0.8	2.7	7.9	2.8	0.4	-0.1
Reaction time number correct	0.2	0.3	0.5	0.7	-0.6	-0.2
Reaction time mean minus median	0.2	0.3	0.5	0.7	-0.2	0.6
Reaction time mean minus median AUC	0.8	1.1	3.1	1.8	-0.3	0.3
Reaction time num false alarms	0.1	0.2	0.3	-0.5	-0.1	-0.5
Reaction time num false alarms AUC	0.2	0.2	0.7	-0.8	0.2	-0.2
Reaction time trials correct on left	0.2	0.3	0.5	0.7	-0.6	-0.2
Reaction time trials on left	0.2	0.4	0.6	0.8	-0.7	-0.2
Reaction time mean	0.7	1.0	2.5	1.6	-0.7	0.2
Reaction time mean AUC	1.0	1.3	2.6	1.6	-1.1	0.4
Median of all reaction times	0.8	1.0	2.4	1.6	-0.8	0.1
Reaction time omissions	0.2	0.3	0.8	0.9	-0.1	-0.2
Reaction time false alarm rate	0.2	0.3	0.8	-0.9	0.3	0.2
Reaction time premature initiation rate	0.2	0.3	0.6	0.0	0.8	0.4
Reaction time premature initiations	0.1	0.2	0.4	0.7	0.2	0.3
Std. dev. reaction times	0.5	0.7	1.4	1.2	-0.3	0.7
Reaction time trials completed	0.2	0.4	0.6	0.8	-0.7	-0.2
Reaction time trials AUC	0.3	0.4	1.0	1.0	-0.5	-0.3
Run reversals in cocaine runway, females	0.6	0.6	0.8	-0.6	0.9	-0.8
Run reversals in cocaine runway, males	1.7	1.6	4.0	-2.0	0.4	-0.8
Latency to leave start box in cocaine runway	1.9	2.1	3.4	0.2	-1.9	1.7
Latency to leave start box in cocaine runway, F	1.3	1.4	2.5	0.2	-1.6	1.3
Latency to leave start box in cocaine runway, M	0.2	0.2	0.4	0.4	0.6	-0.4
Std. dev. time between licks in bursts	1.1	1.3	1.9	-0.4	-1.3	1.4
Total sessions with >9 infusions	1.3	1.4	1.9	1.1	-1.0	-1.4
Short access day 1 total inactive lever presses	1.0	1.1	2.1	0.3	1.5	-1.1
Short access day 10 total inactive lever presses	0.7	0.8	2.3	-1.5	0.2	0.2
Short access day 1 total infusions	1.8	1.9	2.9	1.6	0.5	-1.7
Short access day 10 total infusions	0.6	0.6	1.7	-0.4	-1.3	0.0
Short access total infusions	0.8	0.9	1.2	0.9	-1.1	-0.9
Short access day 1 locomotion	2.6	2.8	6.7	0.7	1.1	-2.6
Short access day 10 total locomotion	1.2	1.4	3.2	0.9	-0.0	-1.8
Short access total locomotion	0.5	0.5	1.0	0.3	-0.6	-1.0
One hour access (0.3 mA shock)	0.4	0.4	0.7	-0.9	-0.7	-0.0
Compulsive drug intake	0.7	0.7	1.2	-1.1	0.7	0.6
One hour access (shock baseline)	0.4	0.4	1.2	0.2	-1.1	-0.1
Social response proportion	2.1	2.3	3.9	-0.3	1.7	-2.0
Social responses	0.5	0.7	1.9	-1.4	0.3	0.2
Social time	0.2	0.2	0.4	-0.6	0.1	0.6
Soleus weight	0.7	2.0	5.1	2.3	0.9	-0.2
Bone: stiffness	3.8	6.0	18.1	4.3	-0.1	0.0
Tibialis anterior weight	0.6	2.2	3.6	1.9	0.7	-1.6
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.2	-0.6	-0.3
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.7	-1.6	-0.9	1.3
Time to tail flick, test, before self-admin	0.3	0.3	0.5	-0.1	-0.7	0.5
Time to tail flick, test, after self-admin	1.1	1.1	2.3	0.0	-1.5	1.0
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.0	-0.8	-0.7	1.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	0.3	-0.4
Tibia length	0.6	1.8	2.7	-1.1	-1.2	1.6
Ambulatory time before self-admin	1.8	1.9	3.7	-0.4	1.9	-1.3
Ambulatory time after self-admin	1.4	1.5	2.3	-0.7	1.5	-1.3
Bone: tissue strength	0.6	0.6	1.6	1.3	-0.3	0.0
Total heroin consumption	0.2	0.2	0.4	-0.2	-0.6	-0.6
Bone: trabecular number	1.1	1.7	2.7	1.6	-0.1	1.5
Bone: trabecular spacing	1.1	1.5	4.2	0.4	-2.0	0.0
Bone: trabecular thickness	0.3	0.3	0.9	0.1	0.9	0.2
Bone: trabecular tissue density	0.0	0.0	0.1	0.2	0.0	0.0
Water consumed over 24 hours	2.2	2.6	4.9	-0.9	2.2	-1.5
Number of responses in last shaping day	0.9	0.9	2.1	0.7	-0.3	-1.5