Hub : Genes

Ccdc61

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA gene expression Ccdc61 0.1 0.08 4.1e-05 0.06 0.07 0.07 0.07 2.7e-04 2.0e-04 1.8e-04 1.8e-04
2 Brain mRNA stability Ccdc61 0.02 0.02 6.8e-03 0.02 0.02 0.02 0.02 8.5e-03 9.6e-03 4.1e-03 6.0e-03
3 NAcc intron excision ratio chr1_87668011_87668458 0.11 0.11 3.7e-06 0.04 0.03 0.03 0.03 1.5e-06 3.2e-05 3.6e-05 8.2e-06
4 OFC gene expression Ccdc61 0.46 0.24 1.6e-08 0.3 0.32 0.29 0.29 8.6e-08 2.0e-08 1.1e-07 1.1e-07
5 LHb gene expression Ccdc61 0.24 0.19 2.6e-04 0.16 0.19 0.16 0.19 1.6e-04 3.3e-05 1.3e-04 3.3e-05
6 NAcc gene expression Ccdc61 0.12 0.09 0.0e+00 0.11 0.12 0.12 0.12 5.0e-16 4.2e-18 7.1e-18 9.1e-18
7 PL gene expression Ccdc61 0.11 0.08 3.4e-13 0.11 0.11 0.1 0.1 1.4e-11 3.7e-12 3.2e-11 1.0e-10
8 Adipose mRNA stability Ccdc61 0.09 0.06 2.7e-11 0.09 0.09 0.08 0.09 6.5e-10 1.3e-10 2.4e-09 6.5e-10
9 IL gene expression Ccdc61 0.23 0.18 3.4e-04 0.08 0.07 0.06 0.07 6.6e-03 9.3e-03 1.2e-02 8.6e-03
10 pVTA gene expression Ccdc61 0.18 0.11 2.3e-11 0.12 0.1 0.12 0.12 5.7e-10 2.9e-08 1.6e-09 1.2e-09
11 Adipose gene expression Ccdc61 0.17 0.09 0.0e+00 0.23 0.24 0.23 0.24 5.2e-25 1.4e-26 1.3e-25 5.4e-26
12 Brain intron excision ratio chr1_87668011_87668532 0.03 0.03 7.9e-04 0.02 0.02 0.01 0.01 5.2e-03 9.3e-03 4.2e-02 1.7e-02
13 pVTA intron excision ratio chr1_87668011_87668458 0.17 0.11 6.7e-09 0.07 0.07 0.06 0.07 2.3e-06 5.1e-06 1.5e-05 4.5e-06
14 Brain gene expression Ccdc61 0.21 0.14 2.2e-16 0.17 0.17 0.16 0.16 2.2e-15 1.2e-15 9.0e-15 7.3e-15
15 PL intron excision ratio chr1_87668011_87668458 0.18 0.11 8.7e-12 0.11 0.11 0.11 0.11 2.1e-12 5.7e-12 3.9e-12 2.9e-12
16 BLA intron excision ratio chr1_87668011_87668458 0.11 0.09 1.4e-04 0.04 0.01 0.01 0.03 3.4e-03 6.1e-02 1.1e-01 8.9e-03
17 Brain intron excision ratio chr1_87668011_87668458 0.17 0.13 1.4e-11 0.12 0.12 0.11 0.12 1.5e-11 1.4e-11 9.4e-11 6.6e-11
18 pVTA intron excision ratio chr1_87668011_87668532 0.16 0.12 6.7e-05 0.03 0.03 0.02 0.02 1.8e-03 1.4e-03 8.5e-03 4.5e-03
19 Brain intron excision ratio chr1_87668011_87668306 0.2 0.16 1.4e-08 0.09 0.09 0.09 0.09 6.0e-09 1.2e-08 4.2e-09 7.3e-09
20 pVTA intron excision ratio chr1_87668011_87668306 0.03 0.03 9.2e-03 0.01 0.01 0 0 6.3e-02 7.2e-02 2.6e-01 1.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Bone: apparent density0.00.00.00.00.1-0.1-0.0-0.0-0.00.00.0-0.0-0.10.0-0.10.10.1-0.10.20.1-0.2-0.10.0
Area under the delay curve1.31.62.41.21.30.81.21.21.21.31.21.21.11.3-1.31.31.31.21.51.4-1.6-1.40.0
BMI with tail0.62.14.2-1.7-1.7-2.0-1.6-1.6-1.6-1.5-1.6-1.5-1.6-1.51.3-1.3-1.4-1.3-1.2-1.31.00.80.0
BMI without tail0.82.55.8-1.9-1.8-2.4-1.8-1.8-1.7-1.7-1.7-1.7-1.9-1.61.3-1.3-1.6-1.5-1.3-1.30.90.90.0
Body weight1.35.59.6-2.8-2.6-3.1-2.6-2.6-2.5-2.5-2.5-2.6-2.7-2.42.1-2.1-2.3-2.1-2.1-2.11.71.60.0
Weight adjusted by age0.00.00.10.10.1-0.3-0.1-0.1-0.1-0.1-0.10.0-0.1-0.10.1-0.1-0.10.10.0-0.0-0.1-0.10.0
Bone surface0.20.40.8-0.6-0.5-0.9-0.7-0.7-0.7-0.7-0.7-0.6-0.7-0.70.6-0.6-0.6-0.7-0.6-0.50.30.10.0
Bone volume0.10.30.5-0.6-0.5-0.7-0.6-0.6-0.6-0.5-0.5-0.5-0.6-0.50.4-0.4-0.5-0.7-0.4-0.40.30.30.0
Breakpoint value in progressive ratio session2.02.43.71.61.61.91.71.71.71.71.71.21.31.7-1.71.71.61.41.51.6-1.4-0.90.0
Number of licking bursts2.54.04.7-2.2-2.1-1.9-2.1-2.1-2.1-2.1-2.1-2.0-2.0-2.12.1-2.1-2.1-2.0-2.1-2.12.11.90.0
Context. condit. distance diff. score0.10.10.2-0.2-0.3-0.1-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.30.4-0.4-0.3-0.4-0.3-0.40.50.40.0
Locomotion velocity, session 10.10.10.10.30.20.40.30.30.30.30.30.20.20.2-0.20.20.20.10.30.2-0.00.40.0
Locomotion distance, session 10.00.00.00.10.10.00.00.00.00.00.00.10.1-0.00.2-0.2-0.0-0.0-0.1-0.10.10.10.0
Locomotion velocity, session 21.41.62.0-1.3-1.3-1.4-1.4-1.4-1.4-1.3-1.3-1.3-1.3-1.31.3-1.3-1.3-1.3-1.2-1.31.20.90.0
Locomotion distance, session 20.20.30.7-0.5-0.4-0.8-0.6-0.6-0.6-0.5-0.6-0.4-0.4-0.50.6-0.6-0.5-0.5-0.5-0.40.40.30.0
Locomotion velocity, session 30.20.30.5-0.6-0.6-0.7-0.6-0.6-0.5-0.5-0.5-0.5-0.5-0.50.5-0.5-0.5-0.4-0.4-0.50.40.30.0
Locomotion distance, session 30.80.81.11.01.00.70.90.90.90.90.91.01.00.9-0.90.90.91.00.91.0-1.0-1.10.0
Stereotopy head waving bouts, day 31.11.31.8-1.3-1.3-1.0-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.21.1-1.1-1.2-1.2-1.1-1.21.21.30.0
Stereotopy head waving duration, day 31.11.31.7-1.3-1.3-0.8-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.11.2-1.2-1.1-1.3-1.2-1.21.31.20.0
Locomotion velocity, session 70.20.20.40.50.50.60.50.50.60.50.50.40.40.5-0.40.40.50.50.40.5-0.4-0.10.0
Locomotion distance, session 70.00.00.1-0.1-0.0-0.3-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.2-0.2-0.10.0-0.2-0.0-0.0-0.10.0
Stereotopy head waving bouts, day 71.11.33.1-1.3-1.3-0.6-1.0-1.0-1.1-1.1-1.1-1.1-1.1-1.11.0-1.0-1.1-1.2-1.1-1.21.31.80.0
Stereotopy head waving duration, day 70.91.12.3-1.2-1.2-0.7-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-1.1-1.0-1.11.21.50.0
Locomotion velocity, session 80.00.00.00.20.2-0.00.10.10.10.10.00.20.20.00.1-0.10.00.10.10.0-0.0-0.10.0
Locomotion distance, session 80.00.00.00.10.1-0.2-0.0-0.0-0.0-0.0-0.00.00.0-0.00.1-0.1-0.0-0.00.00.0-0.1-0.10.0
Degree of sensitization distance0.50.60.7-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.80.8-0.8-0.7-0.7-0.8-0.70.70.60.0
Degree of sensitization stereotypy1.11.23.0-1.2-1.3-0.7-1.0-1.0-1.1-1.1-1.1-1.2-1.2-1.11.0-1.0-1.1-1.2-1.1-1.21.21.70.0
Conditioned locomotion0.00.10.10.30.30.30.20.30.30.20.20.20.20.2-0.20.20.20.30.30.2-0.2-0.20.0
Cocaine response after cond. corrected0.50.61.0-0.8-0.8-0.6-0.7-0.7-0.7-0.8-0.8-0.9-0.8-0.80.8-0.8-0.8-0.8-0.9-0.80.91.00.0
Cocaine response after cond. not corrected1.31.52.2-1.3-1.3-1.1-1.2-1.2-1.2-1.2-1.2-1.4-1.3-1.21.3-1.3-1.3-1.2-1.3-1.31.31.50.0
Cocaine response before conditioning1.61.92.3-1.5-1.5-1.4-1.4-1.4-1.4-1.4-1.4-1.5-1.5-1.41.4-1.4-1.4-1.5-1.3-1.41.31.20.0
Saline control response2.02.73.6-1.8-1.9-1.5-1.6-1.6-1.6-1.7-1.6-1.5-1.5-1.61.7-1.7-1.7-1.7-1.7-1.71.71.70.0
Bone: connectivity density0.10.10.50.40.5-0.10.10.10.10.20.20.10.00.2-0.20.20.30.20.30.4-0.5-0.70.0
Bone: cortical apparent density0.10.10.20.30.30.30.30.30.30.30.30.20.20.3-0.40.40.30.30.40.3-0.3-0.10.0
Bone: cortical area1.52.32.8-1.7-1.7-1.6-1.6-1.6-1.6-1.6-1.6-1.6-1.5-1.61.6-1.6-1.6-1.5-1.6-1.51.41.10.0
Bone: cortical porosity0.10.10.30.40.40.30.30.30.30.30.30.40.40.3-0.40.40.30.40.30.3-0.3-0.60.0
Bone: cortical porosity0.00.00.0-0.1-0.1-0.2-0.1-0.1-0.1-0.1-0.10.00.0-0.1-0.00.0-0.1-0.1-0.1-0.00.0-0.20.0
Bone: cortical thickness0.50.91.1-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.0-1.01.0-1.0-1.0-0.9-0.9-1.00.90.70.0
Bone: cortical thickness1.41.62.2-1.4-1.5-1.2-1.3-1.3-1.3-1.3-1.3-1.2-1.2-1.31.4-1.4-1.3-1.3-1.2-1.31.31.20.0
Bone: cortical tissue density0.10.20.30.40.40.40.40.40.40.40.40.30.30.4-0.50.50.40.40.50.4-0.4-0.20.0
Condit. Reinf. active minus inactive responses0.40.51.0-0.9-0.9-1.0-0.8-0.8-0.7-0.7-0.7-0.8-0.9-0.70.5-0.5-0.7-0.6-0.5-0.60.50.60.0
Condit. Reinf. active-inactive response ratio0.30.30.8-0.8-0.7-0.9-0.6-0.7-0.6-0.6-0.6-0.7-0.7-0.60.3-0.3-0.5-0.6-0.3-0.50.30.50.0
Condit. Reinf. active responses0.20.30.6-0.6-0.6-0.8-0.6-0.6-0.5-0.6-0.5-0.7-0.7-0.50.3-0.3-0.5-0.4-0.3-0.40.30.40.0
Condit. Reinf. inactive responses0.10.10.30.50.50.30.30.30.30.30.30.30.30.3-0.30.30.30.40.30.3-0.3-0.50.0
Incentive salience index mean0.30.40.9-0.8-0.7-1.0-0.7-0.7-0.6-0.7-0.6-0.8-0.8-0.60.3-0.3-0.6-0.5-0.4-0.50.30.50.0
Condit. Reinf. lever presses0.00.10.4-0.3-0.2-0.6-0.3-0.3-0.3-0.3-0.3-0.4-0.4-0.20.0-0.0-0.2-0.1-0.1-0.1-0.1-0.00.0
Condit. Reinf. active minus inactive responses0.00.10.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.20.2-0.2-0.3-0.3-0.2-0.30.30.30.0
Condit. Reinf. active-inactive response ratio0.20.30.5-0.5-0.6-0.3-0.5-0.5-0.5-0.5-0.5-0.4-0.4-0.50.6-0.6-0.6-0.6-0.6-0.60.70.60.0
Condit. Reinf. active responses0.10.10.20.30.40.30.30.30.30.30.30.30.30.3-0.40.40.30.30.40.3-0.3-0.30.0
Condit. Reinf. inactive responses0.60.71.00.90.90.80.90.90.90.90.90.80.80.9-0.90.90.90.81.00.9-0.9-0.90.0
Condit. Reinf. lever presses0.10.10.3-0.4-0.4-0.5-0.4-0.4-0.4-0.4-0.4-0.4-0.3-0.40.4-0.4-0.4-0.2-0.3-0.40.30.30.0
Condit. Reinf. lever reinforcers received0.10.10.20.40.40.30.40.40.40.40.40.40.40.4-0.40.40.40.30.40.3-0.3-0.40.0
Conditioned reinforcement - actives1.22.14.3-1.6-1.5-2.1-1.7-1.7-1.7-1.6-1.6-1.3-1.3-1.61.5-1.5-1.5-1.5-1.4-1.31.00.40.0
Conditioned reinforcement - inactives0.50.82.3-1.0-1.0-1.5-1.1-1.1-1.0-1.0-1.0-0.9-0.9-1.00.7-0.7-0.9-0.5-0.8-0.70.40.40.0
Conditioned locomotion2.02.63.2-1.7-1.7-1.4-1.6-1.6-1.7-1.6-1.6-1.6-1.6-1.71.8-1.8-1.7-1.8-1.7-1.71.81.50.0
Patch foraging indifference point 0 sec0.40.71.3-0.8-0.9-0.5-0.7-0.7-0.8-0.8-0.8-0.6-0.7-0.81.0-1.0-0.8-0.7-0.9-0.91.01.10.0
Patch foraging indifference point AUC3.44.86.5-2.4-2.3-2.5-2.3-2.3-2.2-2.3-2.3-2.5-2.5-2.22.2-2.2-2.2-2.0-2.2-2.11.92.10.0
Delay disc. indifference point, 0s delay1.01.12.11.01.10.51.00.91.01.01.00.91.01.0-1.21.21.11.01.21.3-1.4-1.10.0
Delay disc. indifference point, 16s delay1.01.12.11.01.10.50.90.90.91.01.01.01.01.0-1.11.11.11.01.21.2-1.3-1.50.0
Delay disc. indifference point, 2s delay2.83.24.51.92.01.21.71.71.71.81.81.81.71.8-1.91.91.81.62.12.0-2.1-1.90.0
Delay disc. indifference point, 24s delay0.00.00.1-0.2-0.3-0.0-0.1-0.1-0.1-0.1-0.10.0-0.0-0.10.3-0.3-0.1-0.00.0-0.20.20.20.0
Delay disc. indifference point, 4s delay0.00.00.2-0.10.1-0.4-0.1-0.1-0.1-0.1-0.1-0.2-0.2-0.10.0-0.00.0-0.10.10.1-0.2-0.10.0
Delay disc. indifference point, 8s delay1.31.61.91.21.31.21.31.31.31.31.31.11.11.3-1.41.41.41.31.41.4-1.4-1.00.0
Indifference point function ln k1.01.83.61.41.21.91.51.51.51.41.41.71.81.4-1.21.21.31.01.21.2-0.8-0.90.0
Indifference point function log k1.01.83.61.41.21.91.51.51.51.41.41.71.81.4-1.21.21.31.01.21.2-0.8-0.90.0
Patch foraging total patch changes 0 sec0.51.01.7-1.0-1.0-0.6-0.9-0.9-0.9-0.9-0.9-0.8-0.8-1.01.2-1.2-1.0-0.9-1.1-1.11.21.30.0
Patch foraging total patch changes 12 sec1.72.23.3-1.7-1.7-1.8-1.6-1.6-1.5-1.5-1.5-1.6-1.7-1.51.4-1.4-1.5-1.4-1.4-1.41.21.50.0
Patch foraging total patch changes 18 sec2.03.15.1-1.8-1.8-1.7-1.7-1.7-1.7-1.7-1.7-2.0-2.0-1.71.9-1.9-1.7-1.6-1.8-1.71.72.30.0
Patch foraging total patch changes 24 sec0.40.71.3-0.8-0.8-1.1-0.9-0.9-0.9-0.9-0.8-1.1-1.1-0.80.9-0.9-0.8-0.7-0.7-0.70.50.80.0
Patch foraging total patch changes 6 sec2.33.54.3-2.0-2.0-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.9-1.92.1-2.1-1.9-1.8-2.0-1.91.91.80.0
Patch foraging time to switch 0 sec2.24.55.92.22.31.72.12.12.22.12.12.02.02.1-2.42.42.22.12.22.3-2.3-2.30.0
Patch foraging water rate 0 sec2.65.47.0-2.5-2.6-2.0-2.4-2.3-2.4-2.4-2.4-2.2-2.2-2.42.6-2.6-2.4-2.3-2.4-2.42.52.40.0
Patch foraging water rate 12 sec0.10.20.3-0.4-0.5-0.3-0.4-0.4-0.4-0.4-0.4-0.3-0.2-0.40.5-0.5-0.4-0.2-0.4-0.40.50.50.0
Patch foraging water rate 18 sec0.10.10.2-0.3-0.4-0.2-0.4-0.3-0.4-0.3-0.30.00.0-0.30.5-0.5-0.4-0.4-0.3-0.40.40.10.0
Patch foraging water rate 24 sec0.50.71.6-0.9-1.0-0.4-0.7-0.7-0.7-0.7-0.7-0.7-0.6-0.71.0-1.0-0.8-0.9-0.8-0.91.11.30.0
Patch foraging water rate 6 sec0.50.81.1-0.9-0.9-0.9-0.9-0.9-1.0-0.9-0.9-0.8-0.8-0.91.0-1.0-0.9-0.9-0.8-0.90.80.50.0
Seeking ratio, delayed vs. immediate footshock1.82.23.01.71.61.71.61.61.61.61.61.31.41.6-1.61.61.51.31.51.5-1.3-1.30.0
Distance traveled before self-admin0.00.10.1-0.1-0.2-0.2-0.2-0.2-0.3-0.2-0.2-0.00.0-0.20.4-0.4-0.3-0.1-0.2-0.20.3-0.30.0
Distance traveled after self-admin0.20.30.70.60.50.60.50.50.50.50.50.80.80.5-0.40.40.50.50.50.4-0.4-0.80.0
Extensor digitorum longus weight1.87.28.9-3.0-2.9-3.0-2.8-2.9-2.8-2.8-2.8-2.8-2.9-2.82.7-2.7-2.7-2.7-2.7-2.62.42.00.0
Bone: elastic displacement0.70.81.40.90.80.91.01.01.00.91.00.80.71.0-1.21.20.90.81.00.9-0.9-0.40.0
Bone: elastic work0.10.10.2-0.4-0.4-0.5-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.20.1-0.1-0.2-0.3-0.1-0.20.10.20.0
Bone: endosteal estimation0.00.10.20.10.1-0.20.10.10.20.20.20.20.20.2-0.40.40.20.20.20.3-0.4-0.30.0
Bone: endosteal perimeter0.00.00.2-0.1-0.0-0.3-0.1-0.1-0.1-0.1-0.10.00.1-0.1-0.10.1-0.00.0-0.10.1-0.2-0.40.0
Epididymis fat weight0.20.60.90.80.80.40.70.70.80.70.70.80.60.8-0.90.90.80.90.80.9-1.0-0.80.0
Delta time in closed arm before/after self-admin0.20.20.70.50.40.80.50.60.50.50.50.70.90.5-0.20.20.40.30.40.3-0.1-0.20.0
Delta time in open arm before/after self-admin0.00.00.30.10.2-0.4-0.1-0.1-0.0-0.0-0.0-0.3-0.50.0-0.10.10.10.10.10.2-0.4-0.10.0
Diff in mean of infusions in LGA sessions1.21.52.61.31.31.61.41.41.41.31.30.91.01.3-1.31.31.31.21.21.2-1.0-0.50.0
Delay discount exponential model param1.01.11.7-1.0-1.1-0.7-1.0-1.0-1.0-1.1-1.1-1.0-1.0-1.11.1-1.1-1.1-1.0-1.3-1.21.31.20.0
Extinction: sum of active levers before priming0.00.00.1-0.0-0.00.10.20.20.20.20.2-0.1-0.00.2-0.30.30.2-0.20.10.2-0.20.30.0
Active lever presses in extinction session 60.20.20.4-0.6-0.6-0.7-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.40.2-0.2-0.3-0.4-0.4-0.20.10.50.0
Bone: final force0.40.71.2-0.9-0.9-1.1-0.9-0.9-0.9-0.8-0.9-0.9-0.9-0.80.9-0.9-0.8-0.8-0.8-0.70.60.60.0
Bone: final moment0.61.01.7-1.1-1.0-1.3-1.1-1.1-1.1-1.0-1.0-1.1-1.0-1.01.1-1.1-1.0-0.9-0.9-0.90.80.60.0
Food consumed during 24 hour testing period4.96.88.42.92.92.62.72.72.72.72.72.62.72.7-2.52.52.72.52.72.7-2.6-2.50.0
Glucose0.30.40.70.80.70.90.70.70.70.70.70.70.70.6-0.60.60.60.60.60.5-0.3-0.40.0
Heart weight2.13.24.5-2.0-2.1-1.5-1.8-1.7-1.8-1.8-1.8-1.6-1.6-1.81.9-1.9-1.8-1.8-1.9-1.92.02.00.0
Delay discount hyperbolic model param0.91.01.6-0.9-1.0-0.6-0.9-0.9-1.0-1.0-1.0-0.9-0.9-1.01.1-1.1-1.1-0.9-1.2-1.11.31.10.0
Intermittent access intake day 1-15 change0.10.10.4-0.4-0.3-0.6-0.4-0.4-0.4-0.4-0.4-0.3-0.3-0.40.4-0.4-0.4-0.3-0.3-0.30.2-0.00.0
Intermittent access intake escalation0.10.20.6-0.5-0.4-0.8-0.6-0.6-0.6-0.5-0.5-0.4-0.4-0.50.5-0.5-0.5-0.4-0.4-0.40.3-0.00.0
Intermittent access intake escalation 20.00.00.00.10.00.00.00.00.00.0-0.00.00.0-0.00.1-0.1-0.00.1-0.0-0.00.1-0.20.0
Intermitt. access day 1 inactive lever presses0.00.00.2-0.2-0.0-0.4-0.2-0.2-0.2-0.2-0.2-0.4-0.3-0.20.0-0.0-0.10.0-0.0-0.0-0.10.20.0
Intermitt. access day 15 inactive lever presses0.00.00.20.30.4-0.1-0.1-0.1-0.1-0.1-0.1-0.3-0.5-0.10.0-0.0-0.10.5-0.0-0.0-0.00.30.0
Intermitt. access escalation Index0.20.30.80.70.70.90.60.60.60.60.60.40.40.6-0.60.60.50.40.50.4-0.4-0.20.0
Intermittent access day 1 total infusions1.62.64.5-1.9-1.8-2.1-1.8-1.8-1.7-1.7-1.7-1.7-1.5-1.71.5-1.5-1.6-1.4-1.5-1.51.21.40.0
Intermittent access day 15 total infusions0.81.22.0-1.2-1.2-1.4-1.2-1.2-1.2-1.2-1.2-1.3-1.2-1.11.1-1.1-1.1-1.0-1.0-1.00.81.10.0
Intermittent access terminal intake (last 3 days)1.21.62.0-1.4-1.4-1.4-1.3-1.3-1.2-1.3-1.3-1.4-1.3-1.31.3-1.3-1.2-1.2-1.1-1.21.11.40.0
Intermittent access total infusions2.63.14.4-1.9-1.9-1.8-1.8-1.8-1.8-1.8-1.8-2.0-1.8-1.81.7-1.7-1.8-1.7-1.7-1.71.62.10.0
Intermittent access day 1 locomotion0.30.40.7-0.7-0.6-0.8-0.7-0.7-0.7-0.7-0.7-0.8-0.7-0.70.6-0.6-0.7-0.6-0.6-0.60.50.90.0
Intermittent access day 15 total locomotion0.10.20.3-0.5-0.5-0.6-0.5-0.5-0.5-0.5-0.5-0.3-0.3-0.50.5-0.5-0.5-0.4-0.5-0.50.40.50.0
Intermittent access total locomotion1.61.92.2-1.4-1.4-1.3-1.5-1.5-1.4-1.4-1.4-1.4-1.3-1.41.4-1.4-1.4-1.4-1.4-1.41.31.50.0
Intermittent access standard deviation0.10.20.30.50.60.50.50.50.50.50.50.30.30.5-0.40.40.40.50.50.4-0.4-0.20.0
Left kidney weight5.324.631.7-5.6-5.6-5.5-5.2-5.2-5.1-5.1-5.1-5.1-5.2-5.15.0-5.0-5.0-4.9-4.9-4.94.64.30.0
Right kidney weight5.022.729.5-5.4-5.4-5.0-4.9-4.9-4.9-4.9-4.9-5.0-5.1-4.94.8-4.8-4.8-4.7-4.7-4.74.54.40.0
Cocaine induced anxiety0.10.20.40.40.50.10.30.30.30.30.30.20.10.4-0.60.60.40.40.40.5-0.6-0.40.0
Post-drug Anxiety0.00.00.10.10.10.20.10.10.10.10.10.10.10.1-0.30.30.10.10.10.1-0.1-0.10.0
Baseline Anxiety0.10.11.00.2-0.11.00.40.40.30.30.30.20.40.20.0-0.00.1-0.0-0.0-0.10.60.60.0
Tail length0.41.73.7-1.4-1.3-1.9-1.5-1.5-1.5-1.4-1.4-1.4-1.5-1.41.1-1.1-1.3-1.3-1.2-1.10.80.60.0
Length with tail0.41.73.2-1.5-1.3-1.8-1.4-1.5-1.4-1.4-1.4-1.4-1.5-1.31.2-1.2-1.3-1.3-1.2-1.10.80.70.0
Length without tail0.31.11.7-1.2-1.1-1.2-1.1-1.1-1.1-1.1-1.1-1.3-1.3-1.01.1-1.1-1.0-0.9-1.0-0.90.80.80.0
Times rat made contact with spout0.00.00.20.20.10.40.30.30.30.30.30.20.20.2-0.10.10.20.10.20.10.00.10.0
Lifetime Intake2.63.24.4-2.0-2.0-2.0-1.9-1.9-1.8-1.8-1.8-2.0-1.9-1.81.7-1.7-1.8-1.7-1.7-1.71.62.10.0
Liver weight, left2.33.85.3-2.3-2.3-2.2-2.1-2.1-2.0-2.0-2.0-1.9-1.9-2.01.8-1.8-2.0-2.0-2.0-1.91.81.50.0
Liver weight, right1.52.64.2-2.1-2.0-2.1-1.7-1.8-1.7-1.7-1.7-1.8-1.8-1.61.3-1.3-1.6-1.8-1.4-1.41.21.40.0
Locomotor activity2.13.24.1-2.0-2.0-1.7-1.8-1.8-1.8-1.8-1.8-1.7-1.6-1.81.8-1.8-1.9-1.9-1.9-1.92.02.00.0
Locomotor testing distance1.12.02.6-1.5-1.5-1.6-1.5-1.5-1.5-1.5-1.5-1.2-1.2-1.51.4-1.4-1.5-1.4-1.6-1.41.31.40.0
Locomotor testing rearing4.28.510.6-3.2-3.2-3.3-3.1-3.1-3.0-3.0-3.0-3.0-3.0-3.02.9-2.9-3.0-2.9-3.0-2.92.72.60.0
Locomotion in novel chamber0.30.41.30.70.51.10.70.70.70.60.70.90.90.6-0.40.40.50.30.50.4-0.1-0.40.0
Locomotion in novel chamber post-restriction0.91.42.41.31.31.21.21.21.31.21.21.41.31.2-1.11.11.21.61.11.2-1.1-1.10.0
Fecal boli incidents, locomotor time 10.10.10.4-0.5-0.5-0.2-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.30.2-0.2-0.2-0.6-0.3-0.20.10.00.0
Change in fecal boli incidents, locomotor task0.60.61.20.80.80.60.80.80.90.80.80.70.70.8-0.80.80.81.10.90.9-0.9-0.40.0
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.20.10.00.10.10.10.10.00.10.1-0.10.10.00.40.10.1-0.1-0.20.0
Bouts of movement, locomotor time 12.22.54.11.61.51.71.71.71.81.71.71.61.51.7-1.71.71.62.01.71.6-1.5-0.70.0
Total resting periods, locomotor time 12.93.24.81.81.71.91.91.92.01.91.91.81.61.9-1.91.91.82.21.91.8-1.7-0.90.0
Rest time, locomotor task time 10.20.20.50.40.30.50.50.50.60.50.50.40.30.5-0.50.50.40.70.40.5-0.40.10.0
Distance moved, locomotor task time 10.40.61.1-0.7-0.6-0.9-0.8-0.8-0.9-0.8-0.8-0.8-0.8-0.80.8-0.8-0.7-1.0-0.7-0.70.60.20.0
Vertical activity count, locomotor time 10.00.00.3-0.2-0.1-0.5-0.2-0.2-0.2-0.1-0.1-0.1-0.1-0.1-0.10.1-0.0-0.4-0.00.1-0.3-0.40.0
Time >=10cm from walls, locomotor time 20.10.10.60.50.5-0.00.20.20.20.20.20.30.40.2-0.20.20.20.20.20.3-0.3-0.80.0
Bouts of movement, locomotor time 24.67.39.03.02.93.02.92.92.92.82.82.62.62.8-2.72.72.82.82.82.7-2.5-2.30.0
Total resting periods, locomotor time 23.76.58.72.92.83.02.82.82.72.72.72.42.42.7-2.52.52.62.72.72.5-2.3-2.00.0
Rest time, locomotor task time 20.10.20.70.20.10.90.40.40.40.40.40.10.00.3-0.30.30.20.90.20.10.10.70.0
Distance moved, locomotor task time 20.81.02.7-0.8-0.7-1.4-1.1-1.1-1.1-1.1-1.1-0.9-0.9-1.01.0-1.0-1.0-1.6-0.9-1.00.80.30.0
Vertical activity count, locomotor time 20.10.10.60.10.2-0.5-0.0-0.0-0.00.10.00.20.20.1-0.30.30.2-0.50.20.3-0.6-0.80.0
Light reinforcement 10.00.10.3-0.4-0.5-0.4-0.4-0.3-0.3-0.3-0.3-0.2-0.3-0.30.2-0.2-0.3-0.3-0.4-0.30.20.50.0
Light reinforcement 20.10.20.9-0.4-0.3-1.0-0.5-0.6-0.5-0.5-0.5-0.5-0.6-0.40.2-0.2-0.3-0.2-0.4-0.2-0.10.00.0
Bone: marrow area0.00.00.1-0.0-0.0-0.20.00.00.10.10.10.10.10.1-0.30.30.10.10.10.2-0.3-0.20.0
Bone: maximum diameter2.24.15.2-2.3-2.3-2.2-2.1-2.1-2.1-2.1-2.1-2.2-2.1-2.12.0-2.0-2.1-2.1-2.1-2.01.91.70.0
Bone: maximum force0.20.30.7-0.6-0.5-0.9-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.60.6-0.6-0.5-0.4-0.5-0.40.30.10.0
Bone: maximum moment0.20.41.0-0.7-0.6-1.0-0.8-0.8-0.7-0.7-0.7-0.7-0.7-0.70.8-0.8-0.7-0.4-0.6-0.50.40.10.0
Mean time between licks in bursts0.00.10.10.30.40.10.20.20.20.20.20.10.10.2-0.30.30.30.20.30.3-0.4-0.20.0
Mean num. licks in bursts2.94.55.32.32.22.22.22.32.32.22.22.22.22.2-2.12.12.22.12.22.1-2.0-1.80.0
Cd content in liver0.10.10.50.40.30.70.40.40.40.40.40.20.20.4-0.30.30.30.30.30.2-0.10.20.0
Co content in liver1.21.42.11.41.41.41.21.21.21.21.21.01.01.2-1.21.21.21.21.21.1-1.1-1.00.0
Cu content in liver0.40.50.6-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.7-0.8-0.8-0.70.7-0.7-0.7-0.8-0.7-0.60.60.70.0
Fe content in liver4.85.97.4-2.6-2.6-2.0-2.4-2.4-2.4-2.4-2.4-2.5-2.5-2.52.5-2.5-2.5-2.3-2.5-2.62.72.60.0
K content in liver0.30.30.6-0.7-0.7-0.8-0.6-0.6-0.5-0.5-0.5-0.4-0.4-0.50.5-0.5-0.5-0.5-0.5-0.40.30.10.0
Mg content in liver0.70.71.3-1.0-1.0-1.1-0.9-0.9-0.9-0.9-0.9-0.8-0.8-0.90.8-0.8-0.9-0.9-0.8-0.80.60.50.0
Mn content in liver1.01.11.8-1.2-1.2-1.3-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.11.0-1.0-1.1-0.9-1.0-1.00.80.80.0
Na content in liver0.20.20.5-0.4-0.50.0-0.4-0.3-0.4-0.4-0.4-0.2-0.2-0.40.6-0.6-0.5-0.5-0.6-0.60.70.50.0
Rb content in liver0.10.10.2-0.3-0.4-0.3-0.3-0.2-0.2-0.2-0.2-0.1-0.1-0.20.3-0.3-0.3-0.4-0.3-0.20.20.00.0
Se content in liver4.04.75.9-2.4-2.4-2.4-2.3-2.3-2.3-2.3-2.3-2.2-2.2-2.32.2-2.2-2.2-2.1-2.2-2.22.01.80.0
Sr content in liver0.00.00.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.20.2-0.2-0.2-0.0-0.2-0.20.20.20.0
Zn content in liver0.91.01.7-1.1-1.0-1.3-1.1-1.1-1.1-1.1-1.1-1.0-1.0-1.01.0-1.0-1.0-0.9-1.0-0.90.70.60.0
Bone: minimum diameter0.20.30.5-0.6-0.6-0.7-0.6-0.6-0.6-0.6-0.6-0.5-0.5-0.60.6-0.6-0.6-0.6-0.6-0.50.40.10.0
Time in familiar zone, hab. session 10.10.10.3-0.4-0.4-0.3-0.4-0.3-0.4-0.4-0.4-0.2-0.2-0.40.5-0.5-0.4-0.4-0.5-0.40.50.50.0
Time in novel zone, hab. session 10.70.71.0-0.9-0.9-0.8-0.9-0.9-0.8-0.8-0.8-1.0-1.0-0.80.7-0.7-0.8-0.9-0.7-0.80.70.70.0
Total zone transitions, hab. session 10.10.10.2-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.3-0.2-0.2-0.40.5-0.5-0.4-0.4-0.4-0.40.50.40.0
Total locomotion distance, hab. session 10.40.50.70.80.80.60.70.70.70.70.70.80.80.7-0.70.70.70.70.80.7-0.7-0.70.0
Locomotion velocity, hab. session 11.21.72.01.41.41.11.31.31.31.31.31.41.41.3-1.31.31.31.31.41.3-1.3-1.30.0
Time in familiar zone, hab. session 20.40.40.6-0.7-0.7-0.7-0.6-0.6-0.6-0.6-0.6-0.7-0.7-0.60.5-0.5-0.6-0.8-0.6-0.60.60.80.0
Time in novel zone, hab. session 20.10.10.40.40.30.60.40.40.40.40.40.50.50.3-0.20.20.30.30.30.2-0.1-0.30.0
Total zone transitions, hab. session 20.50.60.8-0.9-0.9-0.7-0.8-0.8-0.8-0.8-0.8-0.7-0.7-0.80.8-0.8-0.8-0.9-0.9-0.90.90.80.0
Total locomotion distance, hab. session 20.50.60.80.80.80.80.80.80.80.80.80.90.90.8-0.80.80.80.70.80.8-0.7-0.70.0
Locomotion velocity, hab. session 20.30.40.60.70.70.50.60.60.60.60.60.80.80.6-0.70.70.60.70.70.7-0.7-0.70.0
Novel to familiar place preference ratio0.30.30.6-0.5-0.4-0.7-0.6-0.6-0.7-0.6-0.6-0.5-0.5-0.60.8-0.8-0.6-0.4-0.6-0.60.50.20.0
Novelty place preference0.30.30.6-0.4-0.3-0.6-0.6-0.6-0.6-0.6-0.6-0.4-0.4-0.60.8-0.8-0.6-0.4-0.6-0.50.50.10.0
Time in novel zone, NPP test0.40.40.8-0.5-0.5-0.6-0.7-0.7-0.7-0.7-0.7-0.5-0.5-0.70.9-0.9-0.7-0.5-0.7-0.70.70.30.0
Total zone transitions, NPP test0.10.10.3-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.4-0.2-0.2-0.40.6-0.6-0.4-0.4-0.4-0.40.40.20.0
Total locomotion distance, NPP test0.10.10.2-0.2-0.3-0.2-0.2-0.2-0.3-0.3-0.3-0.1-0.1-0.30.4-0.4-0.3-0.3-0.4-0.30.40.40.0
Locomotion velocity, NPP test0.00.10.1-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.0-0.20.4-0.4-0.2-0.2-0.3-0.30.30.20.0
Intraocular pressure0.00.00.20.20.10.40.20.20.20.20.20.20.20.1-0.10.10.10.10.10.00.2-0.00.0
Delta distance traveled before/after self-admin1.51.62.61.31.40.91.21.21.21.21.21.41.21.3-1.41.41.31.21.31.4-1.6-1.40.0
Delta ambulatory time before/after self-admin0.30.40.80.70.70.40.60.60.60.60.60.90.70.6-0.70.70.70.60.60.7-0.8-0.90.0
Parametrial fat weight0.10.20.9-0.6-0.8-0.4-0.4-0.4-0.3-0.4-0.4-0.5-0.4-0.40.2-0.2-0.5-0.4-0.3-0.40.40.90.0
Pavlov. Cond. lever latency0.50.71.10.91.00.90.80.80.80.80.80.80.90.8-0.70.70.80.80.70.8-0.8-1.00.0
Pavlov. Cond. magazine entry latency0.10.10.4-0.5-0.5-0.6-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.30.1-0.1-0.3-0.4-0.2-0.30.20.40.0
Pavlov. Cond. change in total contacts0.60.60.90.80.80.60.80.80.80.80.80.70.70.8-1.01.00.80.80.90.8-0.8-0.70.0
Pavlov. Cond. index score0.30.40.6-0.7-0.8-0.7-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.60.4-0.4-0.6-0.6-0.5-0.60.50.70.0
Pavlov. Cond. latency score0.10.10.3-0.4-0.4-0.4-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.30.1-0.1-0.3-0.3-0.2-0.30.20.50.0
Pavlov. Cond. lever contacts0.40.40.8-0.8-0.8-0.7-0.7-0.7-0.6-0.7-0.7-0.7-0.7-0.60.5-0.5-0.7-0.7-0.5-0.60.60.90.0
Pavlov. Cond. magazine entry number0.00.00.10.30.40.40.20.20.20.20.20.20.20.20.0-0.00.20.30.00.2-0.1-0.30.0
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.2-0.10.0-0.2-0.2-0.2-0.2-0.2-0.4-0.4-0.20.4-0.4-0.2-0.1-0.3-0.30.40.40.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.7-0.8-0.7-0.6-0.6-0.6-0.6-0.6-0.6-0.7-0.60.5-0.5-0.6-0.7-0.5-0.60.60.70.0
Pavlov. Cond. response bias0.91.11.7-1.3-1.3-1.3-1.1-1.1-1.1-1.1-1.1-1.1-1.1-1.10.8-0.8-1.0-1.1-0.9-1.00.91.00.0
Pavlov. Cond. lever latency0.00.00.10.10.10.20.20.20.20.10.10.10.10.1-0.10.10.10.10.10.1-0.00.10.0
Pavlov. Cond. magazine entry latency0.00.00.0-0.1-0.1-0.1-0.0-0.0-0.0-0.0-0.0-0.2-0.2-0.00.0-0.0-0.0-0.10.0-0.0-0.00.10.0
Pavlov. Cond. change in total contacts0.20.30.50.60.60.70.60.60.60.60.60.70.70.6-0.50.50.60.50.60.5-0.5-0.60.0
Pavlov. Cond. index score0.00.00.10.20.20.00.20.20.20.20.20.20.20.2-0.20.20.20.20.20.2-0.3-0.40.0
Pavlov. Cond. latency score0.10.10.20.30.40.20.30.30.30.30.30.30.30.3-0.30.30.30.30.30.4-0.4-0.40.0
Pavlov. Cond. lever contacts0.10.10.2-0.3-0.3-0.5-0.3-0.4-0.4-0.3-0.3-0.3-0.3-0.30.3-0.3-0.3-0.3-0.2-0.20.2-0.00.0
Pavlov. Cond. magazine entry number0.30.40.5-0.7-0.7-0.5-0.6-0.6-0.7-0.7-0.7-0.6-0.6-0.70.7-0.7-0.7-0.6-0.7-0.70.70.70.0
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.0-0.00.1-0.0-0.0-0.1-0.0-0.10.00.0-0.10.2-0.2-0.1-0.1-0.1-0.10.20.00.0
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.00.1-0.10.0-0.00.00.00.0-0.00.00.00.0-0.00.00.00.10.1-0.1-0.20.0
Pavlov. Cond. response bias0.00.00.10.00.1-0.10.00.00.00.00.00.00.10.0-0.20.20.10.00.10.1-0.2-0.30.0
Time in closed arm before self-admin0.70.91.4-0.9-0.8-0.9-1.0-1.0-1.0-1.0-1.0-1.0-1.2-1.01.1-1.1-0.9-0.7-0.9-0.90.91.00.0
Time in closed arm after self-admin1.01.02.11.11.01.41.11.11.11.11.11.11.21.0-0.80.81.01.11.00.9-0.7-0.80.0
Time in open arm before self-admin0.70.81.40.70.70.70.90.90.90.90.91.11.20.9-1.11.10.80.70.80.9-0.9-0.90.0
Time in open arm after self-admin0.10.10.20.20.2-0.30.10.10.20.20.2-0.1-0.20.2-0.50.50.20.00.20.3-0.5-0.20.0
Bone: periosteal estimation0.30.51.1-0.9-0.9-1.0-0.8-0.8-0.8-0.8-0.8-0.7-0.6-0.80.6-0.6-0.8-0.7-0.8-0.70.50.30.0
Bone: periosteal perimeter0.30.51.2-0.8-0.7-1.1-0.8-0.8-0.8-0.8-0.8-0.7-0.6-0.80.6-0.6-0.7-0.6-0.7-0.60.40.20.0
Bone: post-yield work0.81.22.91.21.30.61.00.90.91.01.01.01.01.0-1.01.01.11.41.11.2-1.4-1.70.0
Progressive ratio test 1 active lever presses2.73.45.1-2.1-2.0-2.3-2.0-2.0-2.0-2.0-2.0-1.8-1.8-1.91.8-1.8-1.9-1.7-1.8-1.71.51.60.0
Progressive ratio test 1 breakpoint2.63.25.2-2.1-2.1-2.3-2.0-2.0-1.9-1.9-1.9-1.7-1.7-1.81.7-1.7-1.8-1.7-1.6-1.61.31.70.0
Progressive ratio test 1 inactive lever presses1.31.93.6-1.5-1.4-1.9-1.6-1.6-1.5-1.5-1.5-1.2-1.3-1.51.4-1.4-1.4-1.1-1.3-1.31.01.00.0
Progressive ratio test 2 active lever presses2.53.04.5-2.0-1.9-2.1-1.9-1.9-1.9-1.8-1.8-1.8-1.8-1.81.6-1.6-1.7-1.6-1.7-1.61.41.40.0
Progressive ratio test 2 breakpoint2.93.34.9-2.1-2.0-2.2-2.0-2.0-2.0-1.9-1.9-1.9-1.9-1.91.7-1.7-1.8-1.7-1.8-1.71.51.60.0
Progressive ratio test 2 inactive lever presses0.30.41.8-0.8-0.5-1.4-0.8-0.9-0.8-0.8-0.8-0.6-0.6-0.70.4-0.4-0.5-0.2-0.5-0.4-0.00.00.0
Incentive Sensitization - Responses1.21.72.5-1.6-1.5-1.6-1.4-1.5-1.5-1.4-1.4-1.4-1.4-1.41.2-1.2-1.3-1.3-1.3-1.31.10.90.0
Incentive Sensitization - Breakpoint1.21.62.3-1.5-1.4-1.5-1.4-1.4-1.4-1.4-1.3-1.4-1.4-1.31.1-1.1-1.2-1.2-1.2-1.21.00.80.0
Sum of active levers in priming session hrs 5-60.20.20.70.20.20.90.60.60.60.50.50.10.30.5-0.50.50.50.30.40.4-0.20.30.0
Progressive ratio0.91.42.01.41.41.41.31.31.31.31.31.21.21.3-1.21.21.21.01.21.1-1.0-0.70.0
Food seeking constrained by brief footshock5.56.89.52.82.92.52.62.52.52.62.52.62.72.5-2.62.62.72.92.52.7-2.7-3.10.0
Seeking ratio, punishment vs. effort0.71.02.91.01.10.60.80.80.80.90.90.91.00.9-1.01.01.11.30.91.1-1.3-1.70.0
Retroperitoneal fat weight0.00.20.5-0.5-0.6-0.5-0.4-0.4-0.3-0.4-0.4-0.5-0.5-0.40.3-0.3-0.4-0.5-0.4-0.40.40.70.0
Reaction time number correct3.56.89.1-2.8-2.9-2.1-2.6-2.5-2.6-2.6-2.6-2.5-2.4-2.62.9-2.9-2.7-3.0-2.7-2.82.92.50.0
Reaction time mean minus median0.10.31.70.80.61.30.80.80.70.70.70.60.60.6-0.30.30.50.10.40.30.10.00.0
Reaction time mean minus median AUC0.00.10.5-0.1-0.20.60.00.0-0.1-0.1-0.1-0.2-0.2-0.10.3-0.3-0.2-0.6-0.3-0.40.70.50.0
Reaction time num false alarms4.56.48.4-2.9-2.8-2.9-2.7-2.7-2.6-2.6-2.6-2.7-2.6-2.62.4-2.4-2.5-2.6-2.4-2.42.22.30.0
Reaction time num false alarms AUC3.65.67.7-2.8-2.7-2.8-2.5-2.5-2.5-2.5-2.5-2.5-2.4-2.42.2-2.2-2.4-2.4-2.3-2.32.02.10.0
Reaction time trials correct on left3.56.89.1-2.8-2.9-2.1-2.6-2.5-2.6-2.6-2.6-2.5-2.4-2.62.9-2.9-2.7-3.0-2.7-2.82.92.50.0
Reaction time trials on left3.66.89.1-2.8-2.9-2.1-2.6-2.5-2.6-2.6-2.6-2.5-2.5-2.62.9-2.9-2.7-3.0-2.7-2.82.92.50.0
Reaction time mean1.32.02.81.61.51.71.61.61.61.51.51.31.31.5-1.51.51.51.21.41.4-1.2-0.90.0
Reaction time mean AUC1.01.52.31.41.31.51.41.41.41.31.31.21.21.3-1.41.41.31.01.21.2-1.1-0.80.0
Median of all reaction times1.52.23.01.61.61.51.61.61.61.61.61.31.41.6-1.71.71.61.31.51.6-1.5-1.10.0
Reaction time omissions0.00.00.1-0.10.0-0.4-0.1-0.1-0.1-0.0-0.1-0.2-0.3-0.10.0-0.0-0.0-0.20.10.1-0.2-0.20.0
Reaction time false alarm rate0.20.31.1-0.7-0.6-1.1-0.6-0.7-0.6-0.6-0.6-0.7-0.6-0.50.3-0.3-0.5-0.3-0.4-0.40.10.40.0
Reaction time premature initiation rate0.50.61.20.70.60.40.70.70.70.70.71.11.10.7-0.90.90.80.80.80.9-1.0-0.90.0
Reaction time premature initiations0.20.30.7-0.7-0.8-0.5-0.6-0.5-0.6-0.6-0.6-0.1-0.1-0.60.6-0.6-0.6-0.7-0.6-0.60.60.30.0
Std. dev. reaction times0.20.51.40.80.71.20.90.90.80.80.80.70.60.7-0.60.60.70.30.60.5-0.2-0.10.0
Reaction time trials completed3.66.89.1-2.8-2.9-2.1-2.6-2.5-2.6-2.6-2.6-2.5-2.5-2.62.9-2.9-2.7-3.0-2.7-2.82.92.50.0
Reaction time trials AUC4.38.310.8-3.1-3.2-2.4-2.8-2.8-2.9-2.9-2.9-2.8-2.7-2.93.1-3.1-3.0-3.3-3.0-3.13.22.70.0
Run reversals in cocaine runway, females0.30.30.60.80.70.50.60.60.60.60.60.70.70.6-0.50.50.50.70.50.5-0.5-0.80.0
Run reversals in cocaine runway, males0.60.61.3-1.0-1.1-0.6-0.7-0.6-0.6-0.7-0.7-0.7-0.8-0.70.7-0.7-0.7-0.7-0.7-0.70.81.10.0
Latency to leave start box in cocaine runway0.10.10.40.20.20.50.10.1-0.00.00.00.50.6-0.00.3-0.3-0.00.1-0.1-0.20.3-0.30.0
Latency to leave start box in cocaine runway, F0.30.41.1-0.5-0.6-0.0-0.6-0.6-0.7-0.6-0.6-0.10.1-0.71.0-1.0-0.7-0.6-0.7-0.81.00.30.0
Latency to leave start box in cocaine runway, M0.20.20.20.40.50.40.40.40.40.40.40.40.40.4-0.40.40.40.50.40.4-0.4-0.40.0
Std. dev. time between licks in bursts0.00.00.2-0.10.0-0.4-0.2-0.2-0.2-0.1-0.2-0.2-0.2-0.1-0.00.0-0.1-0.10.10.0-0.2-0.00.0
Total sessions with >9 infusions3.94.76.5-2.4-2.4-2.0-2.2-2.2-2.2-2.2-2.2-2.3-2.2-2.22.2-2.2-2.2-2.2-2.2-2.22.22.50.0
Short access day 1 total inactive lever presses0.81.13.0-1.2-1.0-1.7-1.2-1.3-1.2-1.1-1.1-1.2-1.3-1.10.7-0.7-1.0-0.8-0.8-0.70.30.80.0
Short access day 10 total inactive lever presses0.51.21.51.11.21.21.11.11.11.21.20.90.81.2-1.21.21.21.11.21.1-1.1-0.60.0
Short access day 1 total infusions2.02.73.5-1.8-1.8-1.5-1.7-1.7-1.7-1.7-1.7-1.9-1.7-1.71.6-1.6-1.7-1.6-1.7-1.71.61.80.0
Short access day 10 total infusions3.84.86.3-2.5-2.5-2.3-2.3-2.3-2.2-2.2-2.2-2.3-2.2-2.22.2-2.2-2.2-2.2-2.1-2.12.02.50.0
Short access total infusions2.43.14.0-2.0-2.0-1.9-1.9-1.9-1.8-1.8-1.8-1.9-1.8-1.81.7-1.7-1.8-1.7-1.7-1.71.61.90.0
Short access day 1 locomotion3.64.56.1-2.3-2.3-2.4-2.2-2.2-2.1-2.2-2.2-2.5-2.4-2.12.0-2.0-2.1-2.0-2.0-2.01.82.30.0
Short access day 10 total locomotion0.00.00.20.20.10.50.10.10.10.10.1-0.0-0.00.00.1-0.1-0.0-0.2-0.0-0.10.20.40.0
Short access total locomotion0.81.01.7-1.0-1.0-0.9-1.0-1.0-0.9-1.0-1.0-1.1-1.1-0.91.0-1.0-1.0-1.0-0.9-1.00.91.30.0
One hour access (0.3 mA shock)0.00.10.1-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.2-0.3-0.2-0.20.2-0.2-0.2-0.1-0.1-0.10.00.20.0
Compulsive drug intake0.10.10.4-0.2-0.20.2-0.3-0.3-0.3-0.3-0.3-0.1-0.3-0.30.6-0.6-0.4-0.3-0.4-0.50.60.60.0
One hour access (shock baseline)1.01.62.3-1.4-1.4-1.5-1.3-1.3-1.2-1.3-1.3-1.5-1.4-1.21.1-1.1-1.2-1.1-1.1-1.11.01.40.0
Social response proportion0.70.81.8-0.8-0.9-0.6-0.9-0.9-0.9-0.9-0.9-0.9-0.9-0.91.0-1.0-0.9-1.3-1.0-1.01.00.70.0
Social responses0.70.91.4-1.0-1.0-0.9-1.0-1.0-1.0-1.0-1.0-0.9-1.0-1.00.9-0.9-1.0-1.2-1.0-1.01.00.60.0
Social time3.54.87.12.32.42.02.12.12.12.12.12.52.32.2-2.12.12.22.32.32.2-2.3-2.70.0
Soleus weight0.10.30.4-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.6-0.60.5-0.5-0.6-0.6-0.6-0.50.50.30.0
Bone: stiffness0.71.21.7-1.1-1.1-1.3-1.2-1.2-1.2-1.1-1.1-1.1-1.1-1.11.2-1.2-1.1-1.0-1.2-1.00.90.60.0
Tibialis anterior weight3.210.713.4-3.6-3.4-3.7-3.5-3.5-3.5-3.5-3.4-3.4-3.4-3.43.3-3.3-3.3-3.3-3.4-3.22.92.50.0
Time to tail flick, vehicle, before self-admin2.93.04.1-1.9-2.0-1.4-1.7-1.7-1.7-1.7-1.7-1.7-1.7-1.71.7-1.7-1.8-1.7-1.8-1.81.92.00.0
Time to tail flick, vehicle, after self-admin0.00.00.30.0-0.10.50.10.20.10.10.10.30.30.00.1-0.1-0.10.0-0.1-0.20.50.30.0
Time to tail flick, test, before self-admin0.30.30.60.50.50.50.60.60.60.60.60.30.20.6-0.80.80.60.40.60.6-0.60.10.0
Time to tail flick, test, after self-admin0.20.20.50.20.20.10.30.30.30.30.30.60.50.3-0.50.50.40.60.40.4-0.6-0.70.0
Delta time to tail flick, vehicle, before/after SA0.20.20.30.50.50.50.50.50.50.50.40.50.60.4-0.30.30.30.30.40.3-0.2-0.50.0
Delta time to tail flick, test, before/after SA0.70.71.0-0.9-0.9-0.9-0.9-0.9-1.0-0.9-0.9-0.7-0.6-0.91.0-1.0-0.9-0.6-0.8-0.90.80.10.0
Tibia length0.20.61.7-0.9-0.8-1.3-0.9-0.9-0.8-0.8-0.9-0.9-0.9-0.80.7-0.7-0.8-0.6-0.6-0.60.50.60.0
Ambulatory time before self-admin0.00.00.30.10.10.10.10.10.10.10.10.00.10.1-0.00.00.10.20.10.1-0.0-0.50.0
Ambulatory time after self-admin0.60.71.20.90.81.00.80.80.80.80.81.11.00.8-0.70.70.80.80.70.7-0.6-1.10.0
Bone: tissue strength0.90.91.51.01.10.80.90.90.90.90.90.90.90.9-0.90.91.01.11.01.0-1.0-1.20.0
Total heroin consumption0.00.00.1-0.1-0.1-0.2-0.0-0.1-0.0-0.0-0.0-0.2-0.20.0-0.10.10.10.10.10.1-0.3-0.20.0
Bone: trabecular number0.00.10.20.30.40.10.20.20.20.20.20.10.10.2-0.40.40.30.10.40.3-0.4-0.50.0
Bone: trabecular spacing0.00.10.2-0.3-0.40.1-0.2-0.1-0.2-0.2-0.2-0.1-0.0-0.20.3-0.3-0.2-0.1-0.4-0.30.40.30.0
Bone: trabecular thickness1.41.82.4-1.5-1.6-1.4-1.3-1.3-1.3-1.3-1.3-1.4-1.4-1.31.3-1.3-1.3-1.4-1.1-1.31.31.60.0
Bone: trabecular tissue density0.30.51.0-0.9-1.0-0.6-0.6-0.6-0.6-0.6-0.7-0.6-0.5-0.70.6-0.6-0.7-0.8-0.6-0.70.81.00.0
Water consumed over 24 hours0.20.20.50.50.40.70.60.60.60.50.50.50.50.5-0.50.50.50.40.50.4-0.3-0.10.0
Number of responses in last shaping day3.33.68.0-2.0-2.1-1.3-1.7-1.7-1.7-1.8-1.8-2.1-2.2-1.81.9-1.9-1.8-2.1-1.9-1.92.02.80.0