Hub : Genes

Ccdc51

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 BLA mRNA stability Ccdc51 0.13 0.09 4.9e-07 0.12 0.12 0.12 0.12 7.5e-07 6.7e-07 3.8e-07 8.2e-07
2 Liver gene expression Ccdc51 0.07 0.04 4.2e-11 0.09 0.1 0.09 0.1 1.7e-10 1.2e-10 2.6e-10 6.7e-11
3 pVTA alternative TSS XM_006243791.4 0.03 0.02 2.8e-03 0.03 0.02 0.01 0.02 2.7e-03 6.6e-03 2.3e-02 1.5e-02
4 NAcc alternative TSS XM_006243791.4 0.01 0.01 6.6e-03 0.01 0.01 0.01 0.01 2.1e-03 4.4e-03 5.1e-03 4.8e-03
5 Brain mRNA stability Ccdc51 0.15 0.08 3.6e-15 0.16 0.15 0.16 0.16 4.1e-15 1.6e-13 2.8e-14 1.7e-14
6 Adipose mRNA stability Ccdc51 0.04 0.03 4.3e-06 0.04 0.04 0.04 0.04 3.2e-05 2.1e-05 3.7e-05 3.3e-05
7 IC alternative TSS XM_006243791.4 0.07 0.05 1.9e-03 0.03 0.06 0.05 0.05 1.6e-02 1.7e-03 4.1e-03 3.2e-03
8 IC alternative TSS XM_006243790.5 0.07 0.05 1.8e-03 0.03 0.06 0.05 0.05 1.6e-02 1.6e-03 4.1e-03 3.2e-03
9 Liver mRNA stability Ccdc51 0.15 0.08 0.0e+00 0.21 0.2 0.2 0.2 1.1e-22 9.0e-22 6.7e-22 8.0e-22
10 NAcc gene expression Ccdc51 0.01 0.01 5.1e-03 0.01 0.01 0.01 0.01 2.7e-03 1.9e-03 2.4e-03 3.3e-03
11 pVTA alternative TSS XM_006243790.5 0.03 0.02 4.1e-03 0.01 0.02 0 0.01 5.2e-02 1.4e-02 2.6e-01 6.5e-02
12 NAcc mRNA stability Ccdc51 0.04 0.03 9.3e-07 0.04 0.04 0.04 0.04 2.3e-06 2.6e-06 2.0e-06 1.5e-06
13 LHb intron excision ratio chr8_118601369_118616555 0.17 0.11 6.5e-03 0.04 0.06 0.03 0.04 5.0e-02 1.8e-02 7.4e-02 4.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.00.00.2-0.0-0.0-0.00.10.1-0.10.0-0.00.10.10.4-0.40.5
Area under the delay curve1.41.62.1-1.3-1.41.31.3-1.2-1.41.3-1.3-1.5-1.2-0.9-1.4-0.8
BMI with tail0.10.40.70.80.5-0.9-0.60.80.6-0.60.60.30.50.40.60.3
BMI without tail0.61.92.51.61.2-1.4-1.61.61.3-1.31.31.01.31.51.11.4
Body weight4.821.024.65.04.7-4.9-4.54.74.7-4.74.64.54.54.14.73.9
Weight adjusted by age0.00.00.10.30.00.2-0.10.30.2-0.20.2-0.10.1-0.10.0-0.2
Bone surface0.10.20.3-0.5-0.50.40.3-0.3-0.50.5-0.5-0.5-0.5-0.3-0.6-0.3
Bone volume0.00.10.2-0.3-0.30.20.2-0.1-0.30.3-0.3-0.3-0.2-0.1-0.5-0.0
Breakpoint value in progressive ratio session0.10.10.1-0.3-0.30.20.3-0.3-0.30.3-0.3-0.3-0.2-0.1-0.2-0.1
Number of licking bursts0.20.41.1-0.6-0.50.70.4-0.6-0.50.5-0.5-0.5-0.6-0.9-0.2-1.0
Context. condit. distance diff. score0.00.00.00.00.0-0.0-0.10.00.0-0.00.00.00.0-0.00.1-0.1
Locomotion velocity, session 10.00.00.1-0.1-0.20.00.3-0.1-0.20.2-0.2-0.1-0.1-0.0-0.30.0
Locomotion distance, session 11.11.32.01.31.1-1.4-1.11.31.1-1.11.11.01.11.30.91.3
Locomotion velocity, session 20.30.30.4-0.5-0.60.40.6-0.5-0.50.5-0.5-0.6-0.6-0.6-0.5-0.6
Locomotion distance, session 20.00.00.1-0.0-0.1-0.20.10.0-0.10.1-0.1-0.2-0.10.2-0.30.2
Locomotion velocity, session 30.10.20.50.40.3-0.6-0.40.50.3-0.30.30.10.30.60.10.7
Locomotion distance, session 30.91.01.5-1.0-1.10.90.9-0.9-1.11.1-1.1-1.2-1.0-0.8-1.2-0.7
Stereotopy head waving bouts, day 30.00.10.20.10.1-0.0-0.00.10.2-0.20.20.20.0-0.30.5-0.5
Stereotopy head waving duration, day 30.20.20.50.40.5-0.3-0.30.40.5-0.50.50.50.40.20.70.1
Locomotion velocity, session 70.10.20.60.30.3-0.3-0.30.30.3-0.30.30.40.40.70.00.8
Locomotion distance, session 70.91.21.9-1.2-1.21.01.1-1.1-1.11.1-1.1-1.0-1.0-0.8-1.4-0.7
Stereotopy head waving bouts, day 70.00.00.00.00.1-0.00.00.10.0-0.10.10.10.10.1-0.00.2
Stereotopy head waving duration, day 70.40.50.60.70.7-0.7-0.70.80.7-0.70.70.70.70.80.60.8
Locomotion velocity, session 80.30.30.60.60.5-0.8-0.50.70.5-0.50.50.40.50.70.30.7
Locomotion distance, session 80.30.40.90.60.4-0.8-0.60.70.4-0.40.40.40.50.90.21.0
Degree of sensitization distance1.01.11.41.01.1-0.9-1.00.91.1-1.11.11.21.11.01.01.0
Degree of sensitization stereotypy0.10.10.50.30.3-0.3-0.20.30.3-0.30.30.30.40.60.10.7
Conditioned locomotion3.13.64.5-2.0-1.92.01.9-2.0-2.02.0-1.9-1.8-1.8-1.6-2.1-1.5
Cocaine response after cond. corrected0.20.30.90.50.5-0.4-0.60.40.6-0.60.60.50.40.01.0-0.1
Cocaine response after cond. not corrected1.72.03.31.41.4-1.4-1.51.41.5-1.51.51.41.31.01.80.8
Cocaine response before conditioning1.31.62.01.31.2-1.4-1.31.41.2-1.21.21.11.21.41.01.4
Saline control response0.91.22.01.11.1-1.0-1.00.91.0-1.01.01.11.21.30.81.4
Bone: connectivity density0.20.41.1-0.7-0.60.70.7-0.6-0.70.7-0.7-0.5-0.5-0.1-1.10.0
Bone: cortical apparent density0.10.20.3-0.5-0.40.40.5-0.5-0.50.5-0.5-0.4-0.4-0.3-0.6-0.2
Bone: cortical area0.20.31.0-0.5-0.50.50.5-0.5-0.40.4-0.4-0.4-0.6-0.9-0.1-1.0
Bone: cortical porosity0.10.10.5-0.4-0.30.50.3-0.3-0.40.4-0.4-0.3-0.20.2-0.70.4
Bone: cortical porosity0.10.10.4-0.3-0.30.40.3-0.3-0.30.3-0.3-0.2-0.10.2-0.70.4
Bone: cortical thickness0.10.10.60.30.3-0.3-0.20.30.4-0.40.30.30.2-0.30.8-0.5
Bone: cortical thickness0.00.00.1-0.1-0.10.10.2-0.1-0.10.1-0.1-0.1-0.1-0.20.0-0.3
Bone: cortical tissue density0.10.20.3-0.5-0.40.40.4-0.4-0.40.4-0.4-0.4-0.4-0.2-0.6-0.2
Condit. Reinf. active minus inactive responses0.00.10.20.20.2-0.20.00.20.3-0.30.30.40.20.00.3-0.0
Condit. Reinf. active-inactive response ratio0.20.20.40.40.5-0.4-0.20.40.5-0.50.50.60.40.10.60.0
Condit. Reinf. active responses0.00.00.1-0.2-0.10.20.1-0.2-0.10.1-0.1-0.1-0.1-0.30.1-0.3
Condit. Reinf. inactive responses0.50.60.9-0.8-0.80.90.5-0.8-0.80.8-0.8-0.9-0.8-0.7-0.7-0.7
Incentive salience index mean0.10.10.2-0.3-0.30.20.3-0.3-0.20.2-0.2-0.2-0.3-0.4-0.1-0.4
Condit. Reinf. lever presses1.21.72.0-1.3-1.41.21.2-1.4-1.31.3-1.3-1.4-1.3-1.3-1.2-1.3
Condit. Reinf. active minus inactive responses1.41.82.21.41.4-1.5-1.31.41.4-1.41.41.41.31.11.41.1
Condit. Reinf. active-inactive response ratio1.31.51.91.31.3-1.4-1.21.41.3-1.31.31.21.21.01.30.9
Condit. Reinf. active responses1.31.82.11.41.4-1.4-1.21.41.4-1.41.41.41.31.11.31.1
Condit. Reinf. inactive responses0.10.10.1-0.3-0.20.30.4-0.3-0.20.2-0.2-0.1-0.2-0.3-0.3-0.3
Condit. Reinf. lever presses1.92.63.21.71.6-1.8-1.61.71.7-1.61.61.61.61.51.61.4
Condit. Reinf. lever reinforcers received1.62.22.51.61.5-1.6-1.41.61.6-1.51.51.61.51.31.51.2
Conditioned reinforcement - actives1.93.34.4-1.9-2.02.11.8-1.7-1.81.8-1.8-1.9-1.8-1.8-1.7-1.8
Conditioned reinforcement - inactives2.53.65.8-1.9-1.91.72.0-1.8-1.81.8-1.8-1.9-2.0-2.3-1.4-2.4
Conditioned locomotion0.40.50.9-0.7-0.80.80.9-0.6-0.70.7-0.7-0.6-0.6-0.4-0.9-0.3
Patch foraging indifference point 0 sec1.32.43.51.61.6-1.5-1.31.51.5-1.51.51.61.61.81.21.9
Patch foraging indifference point AUC0.00.10.30.20.1-0.4-0.20.10.1-0.10.1-0.00.20.4-0.00.5
Delay disc. indifference point, 0s delay0.00.00.0-0.10.0-0.1-0.10.1-0.00.0-0.00.00.00.10.10.1
Delay disc. indifference point, 16s delay0.80.91.4-0.9-1.01.01.2-0.9-1.01.0-1.0-1.0-0.9-0.7-1.0-0.6
Delay disc. indifference point, 2s delay0.20.20.4-0.4-0.50.50.4-0.3-0.50.5-0.5-0.6-0.4-0.3-0.7-0.3
Delay disc. indifference point, 24s delay0.91.01.3-1.0-1.11.01.1-0.9-1.01.0-1.0-1.1-0.9-0.7-1.1-0.7
Delay disc. indifference point, 4s delay1.41.52.1-1.2-1.41.31.1-1.1-1.31.2-1.2-1.4-1.2-1.1-1.2-1.0
Delay disc. indifference point, 8s delay1.72.02.4-1.5-1.61.51.4-1.4-1.51.5-1.5-1.5-1.4-1.1-1.5-1.0
Indifference point function ln k0.30.50.5-0.7-0.60.60.7-0.7-0.70.7-0.7-0.6-0.7-0.7-0.7-0.7
Indifference point function log k0.30.50.5-0.7-0.60.60.7-0.7-0.70.7-0.7-0.6-0.7-0.7-0.7-0.7
Patch foraging total patch changes 0 sec1.42.53.21.71.7-1.6-1.41.51.6-1.61.61.61.71.81.31.8
Patch foraging total patch changes 12 sec1.11.41.61.21.3-1.3-1.11.11.2-1.21.21.31.21.21.11.2
Patch foraging total patch changes 18 sec1.82.83.91.71.8-1.7-1.31.51.6-1.61.61.71.71.91.52.0
Patch foraging total patch changes 24 sec2.03.44.21.91.9-2.1-1.61.71.9-1.91.91.91.91.81.71.7
Patch foraging total patch changes 6 sec0.30.51.30.70.6-0.7-0.30.60.6-0.60.60.60.81.00.21.2
Patch foraging time to switch 0 sec0.20.40.8-0.6-0.60.80.6-0.4-0.50.5-0.5-0.6-0.6-0.8-0.4-0.9
Patch foraging water rate 0 sec0.20.30.50.60.6-0.5-0.70.50.6-0.60.60.60.60.50.70.5
Patch foraging water rate 12 sec0.10.30.40.50.5-0.6-0.40.50.5-0.50.50.60.50.50.60.5
Patch foraging water rate 18 sec0.00.10.20.30.0-0.2-0.50.30.2-0.20.20.10.1-0.00.4-0.2
Patch foraging water rate 24 sec0.71.01.61.10.9-0.9-1.31.01.0-1.01.01.11.00.91.20.8
Patch foraging water rate 6 sec0.40.50.80.70.7-0.7-0.90.60.7-0.70.70.80.70.70.80.7
Seeking ratio, delayed vs. immediate footshock1.92.33.4-1.6-1.61.81.2-1.4-1.61.6-1.6-1.7-1.5-1.2-1.7-1.1
Distance traveled before self-admin0.40.61.2-0.8-0.80.60.7-0.8-0.70.7-0.7-0.6-0.8-1.0-0.5-1.1
Distance traveled after self-admin0.30.40.6-0.5-0.70.50.6-0.6-0.60.6-0.6-0.6-0.6-0.7-0.4-0.8
Extensor digitorum longus weight0.10.61.0-0.7-0.70.70.7-0.8-0.70.7-0.7-0.8-0.8-0.9-0.5-1.0
Bone: elastic displacement0.00.10.20.20.2-0.2-0.10.10.3-0.30.30.30.2-0.00.4-0.1
Bone: elastic work0.30.40.70.70.6-0.6-0.80.70.7-0.70.60.60.50.30.80.2
Bone: endosteal estimation0.00.10.30.20.2-0.1-0.30.20.1-0.20.20.20.20.4-0.00.5
Bone: endosteal perimeter1.12.32.6-1.6-1.61.51.5-1.4-1.51.5-1.5-1.5-1.5-1.4-1.6-1.3
Epididymis fat weight0.20.81.10.90.9-0.8-0.90.91.0-1.01.01.00.90.81.00.7
Delta time in closed arm before/after self-admin0.50.50.8-0.8-0.50.60.7-0.9-0.70.7-0.7-0.4-0.7-0.6-0.7-0.5
Delta time in open arm before/after self-admin0.20.20.40.60.4-0.4-0.60.60.5-0.50.50.30.50.50.50.4
Diff in mean of infusions in LGA sessions0.10.10.30.30.2-0.4-0.40.30.3-0.30.30.10.1-0.20.6-0.4
Delay discount exponential model param1.61.82.41.41.5-1.4-1.41.31.4-1.41.41.51.31.01.50.9
Extinction: sum of active levers before priming0.00.00.1-0.2-0.20.30.2-0.1-0.20.2-0.2-0.2-0.10.1-0.20.2
Active lever presses in extinction session 60.10.10.40.30.4-0.60.20.30.2-0.20.20.10.30.60.10.6
Bone: final force1.21.92.71.51.4-1.4-1.51.51.4-1.41.41.31.31.01.60.8
Bone: final moment1.32.13.11.61.5-1.5-1.61.61.5-1.51.51.41.31.01.80.8
Food consumed during 24 hour testing period1.31.82.11.41.4-1.4-1.31.41.4-1.41.41.41.31.21.41.2
Glucose1.01.62.11.31.2-1.3-1.41.31.2-1.21.21.21.21.41.01.4
Heart weight1.62.44.41.71.7-1.7-1.61.41.7-1.61.61.61.40.92.10.7
Delay discount hyperbolic model param1.92.12.71.41.6-1.5-1.41.31.5-1.51.51.61.41.11.61.0
Intermittent access intake day 1-15 change1.02.03.2-1.4-1.41.41.8-1.3-1.31.3-1.3-1.4-1.4-1.6-1.2-1.6
Intermittent access intake escalation1.32.74.0-1.6-1.61.62.0-1.5-1.51.5-1.5-1.6-1.6-1.8-1.4-1.9
Intermittent access intake escalation 20.50.61.4-0.8-0.70.71.2-0.7-0.60.6-0.6-0.6-0.7-1.1-0.4-1.2
Intermitt. access day 1 inactive lever presses0.00.10.4-0.2-0.30.40.3-0.2-0.20.2-0.2-0.3-0.3-0.5-0.1-0.6
Intermitt. access day 15 inactive lever presses1.02.13.3-1.4-1.41.31.4-1.3-1.31.3-1.3-1.6-1.5-1.7-1.0-1.8
Intermitt. access escalation Index0.00.00.20.0-0.0-0.10.0-0.0-0.10.1-0.1-0.10.00.3-0.30.4
Intermittent access day 1 total infusions0.30.50.7-0.7-0.70.80.8-0.5-0.70.6-0.6-0.8-0.7-0.6-0.6-0.6
Intermittent access day 15 total infusions2.03.04.7-1.7-1.71.82.2-1.5-1.61.6-1.6-1.8-1.7-1.8-1.6-1.8
Intermittent access terminal intake (last 3 days)1.52.03.4-1.3-1.51.51.8-1.2-1.31.3-1.3-1.5-1.3-1.4-1.4-1.4
Intermittent access total infusions2.12.53.6-1.5-1.71.71.9-1.3-1.51.5-1.5-1.7-1.5-1.6-1.5-1.6
Intermittent access day 1 locomotion0.00.10.20.20.2-0.10.00.40.2-0.20.20.10.30.40.00.4
Intermittent access day 15 total locomotion0.61.02.1-1.1-1.01.11.5-0.9-1.01.0-1.0-0.8-0.9-0.9-1.2-0.8
Intermittent access total locomotion1.21.42.6-1.2-1.21.31.6-1.0-1.11.1-1.1-1.1-1.1-0.9-1.4-0.9
Intermittent access standard deviation0.10.10.7-0.1-0.20.30.70.0-0.00.0-0.0-0.3-0.2-0.60.1-0.8
Left kidney weight0.73.23.91.91.8-2.0-1.71.91.8-1.81.81.71.81.71.71.7
Right kidney weight0.31.51.91.31.2-1.4-1.11.31.2-1.21.21.11.21.31.11.2
Cocaine induced anxiety0.20.30.70.80.5-0.4-0.70.80.6-0.60.60.20.50.50.60.4
Post-drug Anxiety0.00.00.20.30.1-0.0-0.40.30.2-0.20.2-0.00.20.20.20.1
Baseline Anxiety0.30.30.6-0.7-0.60.60.5-0.7-0.60.6-0.6-0.4-0.6-0.5-0.6-0.4
Tail length4.919.121.04.64.5-4.2-4.34.44.4-4.44.44.44.44.34.34.2
Length with tail8.637.341.56.46.4-6.2-5.96.16.3-6.26.26.36.05.56.45.2
Length without tail6.721.525.14.94.9-4.8-4.44.64.8-4.84.84.94.54.05.03.7
Times rat made contact with spout0.70.81.00.90.9-0.9-0.80.80.9-0.90.90.90.90.71.00.7
Lifetime Intake2.43.04.8-1.8-1.81.82.2-1.5-1.71.6-1.6-1.8-1.7-1.6-1.7-1.6
Liver weight, left0.71.21.51.11.1-1.0-1.01.01.0-1.01.01.01.11.21.01.2
Liver weight, right1.73.03.71.81.7-1.7-1.91.71.6-1.71.71.61.71.81.61.8
Locomotor activity5.78.99.83.13.1-3.1-2.93.03.0-3.03.03.03.02.92.92.8
Locomotor testing distance3.97.07.82.82.8-2.7-2.62.62.7-2.72.72.72.62.52.72.4
Locomotor testing rearing0.00.00.00.10.2-0.1-0.1-0.00.2-0.20.20.20.10.10.20.0
Locomotion in novel chamber0.10.10.4-0.3-0.20.30.5-0.2-0.20.2-0.2-0.2-0.3-0.5-0.2-0.6
Locomotion in novel chamber post-restriction0.40.61.00.70.9-1.0-0.50.60.7-0.70.71.00.80.90.70.9
Fecal boli incidents, locomotor time 10.40.60.90.70.8-0.6-0.90.90.8-0.80.80.60.70.60.90.6
Change in fecal boli incidents, locomotor task0.10.10.1-0.2-0.40.30.3-0.3-0.30.3-0.3-0.1-0.2-0.2-0.3-0.1
Time >=10cm from walls, locomotor time 10.20.20.5-0.6-0.40.40.7-0.6-0.50.5-0.5-0.3-0.4-0.3-0.6-0.1
Bouts of movement, locomotor time 10.10.10.30.40.3-0.3-0.50.30.3-0.30.30.10.30.20.30.2
Total resting periods, locomotor time 10.00.00.10.30.2-0.2-0.30.10.2-0.20.20.10.20.20.20.1
Rest time, locomotor task time 10.50.70.9-0.9-0.80.80.6-1.0-0.90.9-0.9-0.9-0.9-0.8-0.6-0.7
Distance moved, locomotor task time 11.01.52.11.31.3-1.3-1.21.21.3-1.31.31.41.21.01.20.9
Vertical activity count, locomotor time 10.51.21.71.21.1-1.1-1.31.01.1-1.11.11.11.11.01.10.9
Time >=10cm from walls, locomotor time 20.91.41.81.21.3-1.2-1.01.01.2-1.21.21.31.21.11.31.1
Bouts of movement, locomotor time 20.00.10.2-0.3-0.40.30.3-0.0-0.20.2-0.2-0.2-0.3-0.4-0.2-0.5
Total resting periods, locomotor time 20.10.20.4-0.5-0.60.60.4-0.3-0.40.4-0.4-0.5-0.5-0.6-0.5-0.6
Rest time, locomotor task time 20.00.10.1-0.2-0.20.3-0.2-0.3-0.30.3-0.3-0.4-0.2-0.1-0.0-0.1
Distance moved, locomotor task time 20.91.01.81.01.1-1.2-0.41.01.1-1.11.11.31.00.80.80.7
Vertical activity count, locomotor time 20.00.10.10.20.3-0.3-0.00.10.3-0.30.30.40.20.20.00.2
Light reinforcement 10.51.11.31.11.1-0.9-1.01.11.1-1.11.10.91.11.11.01.0
Light reinforcement 20.10.10.3-0.3-0.30.20.1-0.2-0.40.4-0.4-0.4-0.30.0-0.60.1
Bone: marrow area0.00.10.30.20.2-0.1-0.30.30.2-0.20.20.20.30.50.00.6
Bone: maximum diameter0.40.71.4-0.8-0.80.80.7-0.7-0.70.7-0.8-0.8-0.9-1.1-0.5-1.2
Bone: maximum force0.71.31.61.21.1-1.1-1.21.21.2-1.21.11.11.11.01.20.9
Bone: maximum moment0.81.31.71.21.2-1.1-1.21.21.2-1.21.21.11.10.91.30.8
Mean time between licks in bursts0.92.12.4-1.5-1.51.41.6-1.4-1.41.4-1.4-1.4-1.4-1.4-1.4-1.4
Mean num. licks in bursts0.81.32.21.11.1-1.2-0.91.11.0-1.01.01.11.21.40.71.5
Cd content in liver0.10.10.2-0.3-0.30.20.3-0.3-0.30.3-0.3-0.3-0.2-0.1-0.50.0
Co content in liver1.72.02.6-1.5-1.41.41.6-1.4-1.31.3-1.3-1.2-1.4-1.5-1.2-1.5
Cu content in liver4.35.16.42.42.4-2.1-2.52.32.2-2.22.22.12.22.22.32.1
Fe content in liver1.11.31.71.21.3-1.0-1.11.01.2-1.21.21.31.20.91.30.8
K content in liver0.30.30.60.60.5-0.5-0.80.60.5-0.50.50.30.40.50.50.5
Mg content in liver0.80.81.5-0.9-1.00.80.5-0.7-1.01.0-1.0-1.2-1.0-0.8-0.9-0.8
Mn content in liver0.00.00.20.10.0-0.3-0.20.10.0-0.00.0-0.10.10.4-0.20.5
Na content in liver0.60.60.80.80.9-0.6-0.70.60.8-0.80.80.90.90.90.70.9
Rb content in liver0.40.50.90.70.8-0.4-0.60.40.8-0.80.81.00.70.50.90.4
Se content in liver0.10.10.20.30.2-0.4-0.50.40.2-0.20.20.10.20.20.20.2
Sr content in liver0.00.00.2-0.0-0.2-0.3-0.10.2-0.20.2-0.2-0.4-0.20.0-0.30.0
Zn content in liver2.32.63.01.71.7-1.5-1.71.71.6-1.61.61.51.61.71.51.6
Bone: minimum diameter0.61.11.2-1.1-1.11.10.9-1.0-1.11.1-1.1-1.1-1.1-1.1-1.0-1.1
Time in familiar zone, hab. session 11.91.82.2-1.4-1.31.51.4-1.5-1.31.3-1.3-1.2-1.3-1.5-1.1-1.5
Time in novel zone, hab. session 10.90.91.21.01.0-1.0-1.01.10.9-0.90.90.90.90.90.90.9
Total zone transitions, hab. session 10.70.91.51.00.9-1.2-0.81.10.9-0.90.90.80.91.10.61.2
Total locomotion distance, hab. session 10.30.50.70.80.6-0.8-0.70.70.6-0.60.60.60.70.80.50.8
Locomotion velocity, hab. session 10.40.60.90.80.7-0.9-0.70.80.7-0.70.70.60.70.90.51.0
Time in familiar zone, hab. session 20.80.91.5-0.9-0.91.00.7-0.9-0.80.9-0.9-0.9-0.9-1.1-0.6-1.2
Time in novel zone, hab. session 20.10.10.30.20.2-0.2-0.10.20.2-0.20.20.30.30.4-0.00.5
Total zone transitions, hab. session 20.10.10.40.40.3-0.6-0.40.50.3-0.30.30.20.30.30.20.3
Total locomotion distance, hab. session 20.50.60.90.90.7-0.9-0.90.80.7-0.70.70.60.70.80.70.8
Locomotion velocity, hab. session 20.40.50.80.80.7-0.9-0.80.70.6-0.60.60.60.70.80.60.8
Novel to familiar place preference ratio0.91.03.00.80.8-0.8-1.01.00.7-0.80.80.81.01.50.31.7
Novelty place preference0.91.03.20.80.8-0.7-1.00.90.7-0.80.80.81.01.60.21.8
Time in novel zone, NPP test1.11.23.20.91.0-0.8-1.11.10.8-0.90.90.91.11.60.41.8
Total zone transitions, NPP test2.84.05.62.21.9-2.4-2.12.21.9-1.91.91.71.92.21.62.2
Total locomotion distance, NPP test1.41.92.41.51.3-1.6-1.41.41.3-1.31.31.21.31.41.21.4
Locomotion velocity, NPP test1.52.12.71.61.4-1.7-1.51.51.4-1.41.41.21.41.61.31.6
Intraocular pressure0.91.21.71.01.2-0.9-1.00.91.1-1.11.11.31.21.21.11.3
Delta distance traveled before/after self-admin0.10.10.20.50.2-0.3-0.30.40.3-0.30.30.10.30.50.20.5
Delta ambulatory time before/after self-admin0.91.21.61.31.0-1.0-1.11.11.0-1.01.00.81.11.21.01.2
Parametrial fat weight0.92.02.41.51.5-1.4-1.51.51.5-1.41.41.41.41.31.21.2
Pavlov. Cond. lever latency4.55.76.32.52.5-2.3-2.22.42.4-2.42.42.52.42.42.22.4
Pavlov. Cond. magazine entry latency7.810.011.0-3.3-3.23.23.1-3.1-3.13.1-3.1-3.2-3.2-3.2-2.9-3.2
Pavlov. Cond. change in total contacts1.92.02.4-1.5-1.41.41.5-1.5-1.31.3-1.4-1.3-1.4-1.5-1.2-1.5
Pavlov. Cond. index score6.78.49.4-3.0-3.02.92.8-2.9-2.82.9-2.9-2.9-2.9-3.0-2.6-3.1
Pavlov. Cond. latency score6.58.28.9-3.0-3.02.82.8-2.9-2.82.8-2.8-2.9-2.9-3.0-2.6-3.0
Pavlov. Cond. lever contacts2.53.03.4-1.8-1.81.61.6-1.7-1.71.7-1.7-1.8-1.8-1.8-1.6-1.8
Pavlov. Cond. magazine entry number8.010.111.03.33.2-3.2-3.23.23.1-3.13.13.13.23.32.93.3
Pavlov. Cond. intertrial magazine entries0.30.40.50.60.6-0.5-0.70.50.6-0.60.60.60.60.70.60.7
Pavlov. Cond. lever-magazine prob. diff.5.97.38.8-2.8-2.72.62.6-2.7-2.62.7-2.7-2.7-2.8-2.9-2.3-3.0
Pavlov. Cond. response bias7.08.79.9-3.1-3.02.92.9-2.9-2.92.9-2.9-3.0-3.0-3.1-2.6-3.1
Pavlov. Cond. lever latency0.50.70.9-0.9-0.80.90.8-1.0-0.80.8-0.8-0.8-0.8-0.8-0.7-0.7
Pavlov. Cond. magazine entry latency0.10.20.3-0.4-0.50.30.2-0.3-0.40.4-0.4-0.5-0.5-0.4-0.4-0.5
Pavlov. Cond. change in total contacts1.93.03.61.81.7-1.8-1.71.91.8-1.81.81.71.71.51.81.4
Pavlov. Cond. index score0.10.20.30.40.3-0.5-0.50.60.4-0.40.40.30.30.30.40.2
Pavlov. Cond. latency score0.10.10.20.30.2-0.4-0.40.40.3-0.20.20.20.20.20.30.1
Pavlov. Cond. lever contacts0.81.11.41.11.0-1.1-1.01.21.0-1.01.01.01.01.00.91.0
Pavlov. Cond. magazine entry number0.20.20.30.50.5-0.5-0.30.40.5-0.50.50.60.50.50.50.5
Pavlov. Cond. intertrial magazine entries0.60.91.3-1.0-0.91.01.2-1.1-0.90.9-0.9-0.8-0.9-1.0-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.30.3-0.4-0.50.50.3-0.30.30.20.30.20.30.2
Pavlov. Cond. response bias0.00.00.10.20.1-0.3-0.20.40.2-0.20.20.20.10.10.20.1
Time in closed arm before self-admin0.50.71.00.90.9-0.9-0.41.00.9-0.90.90.80.90.80.70.7
Time in closed arm after self-admin0.30.30.4-0.6-0.40.50.6-0.6-0.50.5-0.5-0.3-0.5-0.7-0.4-0.7
Time in open arm before self-admin0.60.71.3-0.8-0.81.10.5-0.9-0.80.8-0.8-0.8-0.8-0.7-0.8-0.7
Time in open arm after self-admin0.20.20.4-0.3-0.50.60.1-0.4-0.50.5-0.4-0.5-0.30.1-0.60.2
Bone: periosteal estimation0.00.00.0-0.0-0.00.1-0.10.0-0.00.0-0.0-0.0-0.0-0.10.1-0.1
Bone: periosteal perimeter1.01.71.9-1.4-1.31.31.3-1.3-1.31.3-1.3-1.3-1.3-1.3-1.2-1.3
Bone: post-yield work0.00.00.10.10.1-0.1-0.20.20.1-0.10.10.10.10.20.00.2
Progressive ratio test 1 active lever presses0.00.10.4-0.1-0.20.10.6-0.0-0.10.1-0.1-0.2-0.00.1-0.40.2
Progressive ratio test 1 breakpoint0.00.10.4-0.1-0.20.10.6-0.0-0.20.1-0.1-0.2-0.10.1-0.40.2
Progressive ratio test 1 inactive lever presses0.40.61.2-0.7-0.80.71.1-0.7-0.70.7-0.7-0.8-0.8-1.0-0.5-1.0
Progressive ratio test 2 active lever presses2.02.32.8-1.5-1.61.71.7-1.3-1.51.5-1.5-1.6-1.5-1.5-1.4-1.5
Progressive ratio test 2 breakpoint2.02.32.8-1.5-1.71.71.7-1.3-1.51.5-1.5-1.6-1.5-1.5-1.3-1.5
Progressive ratio test 2 inactive lever presses2.33.75.5-1.8-2.02.02.2-1.7-1.71.8-1.8-2.0-1.9-2.2-1.5-2.4
Incentive Sensitization - Responses2.02.83.6-1.7-1.81.91.6-1.6-1.61.6-1.6-1.8-1.7-1.8-1.2-1.9
Incentive Sensitization - Breakpoint2.22.93.7-1.7-1.81.91.6-1.6-1.61.6-1.6-1.8-1.7-1.9-1.3-1.9
Sum of active levers in priming session hrs 5-60.10.10.40.20.1-0.10.10.30.1-0.20.20.10.30.6-0.10.7
Progressive ratio2.94.55.02.22.1-2.0-2.12.22.1-2.12.12.12.12.22.02.2
Food seeking constrained by brief footshock1.21.42.5-1.4-1.10.91.6-1.4-1.21.2-1.2-0.9-1.2-1.2-1.0-1.1
Seeking ratio, punishment vs. effort4.97.18.1-2.8-2.62.42.7-2.9-2.62.6-2.7-2.6-2.7-2.8-2.4-2.8
Retroperitoneal fat weight1.46.27.32.62.6-2.5-2.32.52.6-2.52.52.72.52.32.42.2
Reaction time number correct0.51.01.4-1.2-1.01.11.2-1.1-0.90.9-0.9-0.6-0.9-1.0-0.8-1.0
Reaction time mean minus median0.10.20.60.40.3-0.5-0.80.40.3-0.30.30.30.30.40.30.4
Reaction time mean minus median AUC0.20.40.90.70.5-0.7-0.90.60.5-0.50.50.50.60.70.40.7
Reaction time num false alarms0.30.40.5-0.6-0.60.60.7-0.7-0.60.6-0.6-0.6-0.6-0.5-0.6-0.5
Reaction time num false alarms AUC0.10.10.2-0.3-0.30.30.3-0.4-0.30.3-0.3-0.3-0.2-0.1-0.4-0.0
Reaction time trials correct on left0.51.01.4-1.2-1.01.11.2-1.1-0.90.9-0.9-0.6-0.9-1.0-0.8-1.0
Reaction time trials on left0.51.01.5-1.2-1.01.21.2-1.1-1.01.0-1.0-0.7-0.9-1.0-0.8-1.0
Reaction time mean0.00.00.1-0.1-0.10.10.0-0.1-0.10.0-0.00.20.00.1-0.20.2
Reaction time mean AUC0.00.00.1-0.2-0.20.20.1-0.1-0.10.1-0.10.1-0.00.1-0.40.2
Median of all reaction times0.10.10.2-0.4-0.30.40.4-0.3-0.30.2-0.20.0-0.2-0.1-0.5-0.0
Reaction time omissions0.00.10.2-0.3-0.20.30.4-0.4-0.30.2-0.2-0.1-0.1-0.0-0.50.1
Reaction time false alarm rate0.00.00.00.10.1-0.1-0.1-0.00.0-0.00.0-0.10.10.1-0.10.2
Reaction time premature initiation rate2.53.54.52.11.9-2.0-1.52.11.9-1.91.91.71.91.91.61.8
Reaction time premature initiations0.81.51.91.41.2-1.3-0.71.41.3-1.31.31.21.31.21.01.1
Std. dev. reaction times0.10.20.50.40.3-0.5-0.50.40.3-0.40.40.50.40.60.10.7
Reaction time trials completed0.51.01.5-1.2-1.01.21.2-1.1-1.01.0-1.0-0.7-0.9-1.0-0.8-1.0
Reaction time trials AUC0.71.31.8-1.3-1.11.31.3-1.2-1.11.1-1.1-0.8-1.1-1.1-0.9-1.1
Run reversals in cocaine runway, females1.81.72.3-1.5-1.21.01.5-1.5-1.31.3-1.3-0.9-1.3-1.5-1.2-1.5
Run reversals in cocaine runway, males1.31.31.91.41.1-1.1-0.91.21.3-1.31.21.11.10.81.30.7
Latency to leave start box in cocaine runway0.40.40.80.70.6-0.7-0.60.70.6-0.60.60.60.60.50.90.5
Latency to leave start box in cocaine runway, F0.80.91.61.01.0-1.1-0.81.01.0-1.01.01.00.80.51.30.3
Latency to leave start box in cocaine runway, M0.40.30.7-0.6-0.70.60.5-0.5-0.70.7-0.7-0.8-0.6-0.3-0.5-0.3
Std. dev. time between licks in bursts5.06.78.8-2.7-2.62.62.5-2.5-2.52.5-2.5-2.5-2.6-2.9-2.2-3.0
Total sessions with >9 infusions0.70.81.3-0.9-0.90.81.1-0.8-0.80.8-0.8-0.9-0.9-1.0-0.5-1.1
Short access day 1 total inactive lever presses4.96.47.6-2.8-2.52.52.6-2.6-2.52.5-2.5-2.4-2.5-2.5-2.3-2.5
Short access day 10 total inactive lever presses0.10.20.70.50.4-0.5-0.70.50.5-0.50.50.20.3-0.10.9-0.4
Short access day 1 total infusions3.34.45.6-2.2-2.22.12.4-2.0-2.12.1-2.1-2.1-2.1-2.0-2.0-1.9
Short access day 10 total infusions2.73.45.4-1.9-1.91.92.3-1.8-1.81.8-1.8-1.8-1.8-1.7-1.9-1.6
Short access total infusions4.05.27.3-2.5-2.32.22.7-2.2-2.32.3-2.3-2.2-2.2-2.1-2.3-1.9
Short access day 1 locomotion0.50.60.8-0.8-0.80.80.9-0.7-0.80.8-0.8-0.9-0.8-0.8-0.6-0.8
Short access day 10 total locomotion0.00.00.3-0.00.0-0.10.50.00.0-0.00.00.10.10.2-0.30.3
Short access total locomotion0.00.10.3-0.2-0.20.10.5-0.1-0.20.2-0.2-0.2-0.10.0-0.40.1
One hour access (0.3 mA shock)1.01.22.9-1.1-1.11.11.7-1.0-1.11.0-1.0-1.0-1.0-0.8-1.3-0.7
Compulsive drug intake0.91.11.6-1.3-1.00.90.9-1.3-1.21.2-1.2-0.9-1.0-0.8-1.2-0.6
One hour access (shock baseline)0.30.51.4-0.5-0.80.81.2-0.4-0.60.6-0.6-0.8-0.7-0.7-0.7-0.8
Social response proportion0.30.30.70.50.6-0.6-0.30.40.6-0.60.60.80.60.50.40.5
Social responses0.50.60.80.90.7-0.6-0.90.80.8-0.80.80.70.80.90.60.9
Social time0.40.61.3-0.7-0.70.80.8-0.5-0.60.7-0.7-0.8-0.8-1.0-0.5-1.1
Soleus weight4.112.114.23.83.6-3.6-3.63.53.5-3.53.53.33.43.23.63.0
Bone: stiffness0.20.30.40.60.5-0.5-0.60.60.5-0.50.50.50.50.50.50.5
Tibialis anterior weight0.00.10.20.30.2-0.2-0.20.20.3-0.20.20.10.1-0.10.5-0.2
Time to tail flick, vehicle, before self-admin1.41.52.21.21.4-0.9-1.11.21.3-1.31.31.51.31.21.11.2
Time to tail flick, vehicle, after self-admin0.30.40.80.70.6-0.6-0.50.90.7-0.70.70.30.60.40.60.3
Time to tail flick, test, before self-admin0.10.10.50.30.3-0.2-0.20.30.1-0.20.20.00.30.60.00.7
Time to tail flick, test, after self-admin0.10.20.4-0.3-0.40.60.4-0.3-0.30.3-0.3-0.4-0.4-0.4-0.3-0.5
Delta time to tail flick, vehicle, before/after SA0.30.30.6-0.4-0.60.40.3-0.2-0.40.5-0.5-0.8-0.5-0.6-0.4-0.7
Delta time to tail flick, test, before/after SA0.40.40.6-0.6-0.70.80.6-0.5-0.50.5-0.5-0.5-0.6-0.7-0.6-0.7
Tibia length6.919.021.74.74.4-4.6-4.64.64.4-4.34.34.14.24.14.33.9
Ambulatory time before self-admin1.01.52.1-1.2-1.21.11.4-1.2-1.11.1-1.1-1.1-1.2-1.4-1.0-1.4
Ambulatory time after self-admin0.10.10.2-0.1-0.30.20.4-0.2-0.20.2-0.2-0.4-0.2-0.2-0.3-0.2
Bone: tissue strength2.82.83.71.81.8-1.7-1.71.71.7-1.71.71.71.61.31.91.2
Total heroin consumption1.61.92.91.71.4-1.6-1.31.51.5-1.51.51.11.31.01.60.8
Bone: trabecular number0.71.12.3-1.2-1.11.01.2-1.0-1.11.1-1.1-0.9-0.9-0.6-1.5-0.4
Bone: trabecular spacing1.52.03.51.51.5-1.4-1.51.41.5-1.51.51.41.30.91.90.7
Bone: trabecular thickness0.10.10.50.30.2-0.3-0.20.40.2-0.20.20.20.30.6-0.20.7
Bone: trabecular tissue density0.50.70.80.90.9-0.9-0.90.90.8-0.80.80.70.80.90.80.8
Water consumed over 24 hours0.10.10.30.30.2-0.3-0.30.30.3-0.30.30.20.1-0.10.5-0.3
Number of responses in last shaping day0.30.41.1-0.5-0.60.50.5-0.4-0.40.5-0.5-0.8-0.6-0.9-0.3-1.1