Hub : Genes

Ccdc25

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL alternative polyA NM_001108382.1 0.09 0.06 1.2e-06 0.06 0.06 0.05 0.06 2.0e-07 9.0e-07 2.5e-06 2.5e-07
2 PL alternative polyA XM_039093513.1 0.08 0.05 1.9e-05 0.06 0.04 0.04 0.05 2.1e-07 2.7e-05 3.1e-05 5.8e-06
3 Liver gene expression Ccdc25 0.34 0.14 0.0e+00 0.27 0.28 0.28 0.28 4.3e-30 5.9e-31 8.1e-31 1.4e-30
4 Adipose gene expression Ccdc25 0.06 0.04 2.2e-05 0.01 0.02 0.02 0.01 1.7e-02 3.5e-03 4.3e-03 1.9e-02
5 Brain mRNA stability Ccdc25 0.03 0.02 7.5e-03 0.01 0.02 0.01 0.01 1.7e-02 8.7e-03 8.4e-02 1.3e-02
6 LHb gene expression Ccdc25 0.32 0.15 3.8e-05 0.08 0.1 0.09 0.12 6.3e-03 2.9e-03 3.6e-03 1.1e-03
7 Brain gene expression Ccdc25 0.21 0.1 0.0e+00 0.24 0.23 0.22 0.22 5.6e-22 3.6e-21 1.1e-20 2.0e-20
8 IL gene expression Ccdc25 0.32 0.14 2.1e-05 0.17 0.13 0.15 -0.01 6.4e-05 5.5e-04 1.5e-04 6.0e-01
9 BLA gene expression Ccdc25 0.25 0.1 1.9e-12 0.17 0.17 0.17 0.1 2.8e-09 2.9e-09 3.4e-09 4.8e-06
10 PL gene expression Ccdc25 0.19 0.09 0.0e+00 0.22 0.21 0.21 0.22 3.3e-23 7.5e-23 3.7e-23 2.2e-23
11 pVTA gene expression Ccdc25 0.37 0.12 2.6e-15 0.26 0.33 0.32 0.33 1.0e-11 6.5e-15 1.6e-14 6.6e-15
12 BLA intron excision ratio chr15_40064340_40071614 0.16 0.11 7.8e-03 0.04 0.01 0.01 -0 3.9e-03 5.9e-02 1.5e-01 6.5e-01
13 OFC gene expression Ccdc25 0.5 0.18 3.5e-06 0.04 0.12 0.08 0.08 4.3e-02 8.0e-04 6.0e-03 6.2e-03
14 NAcc gene expression Ccdc25 0.17 0.07 0.0e+00 0.2 0.08 0.22 0.11 3.5e-22 2.5e-09 7.8e-25 8.6e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.01.82.70.2-0.2-1.3-1.21.2-1.51.51.61.5-1.5-1.61.5-1.51.2
Area under the delay curve0.10.10.40.4-0.4-0.2-0.20.10.1-0.3-0.3-0.30.30.4-0.20.60.5
BMI with tail0.61.92.5-0.70.71.51.4-1.41.5-1.5-1.6-1.61.51.4-1.41.4-1.2
BMI without tail0.20.42.0-1.41.40.60.7-0.70.2-0.3-0.2-0.20.2-0.0-0.1-0.0-0.3
Body weight0.10.20.80.9-0.90.0-0.10.10.3-0.4-0.5-0.50.40.5-0.40.5-0.4
Weight adjusted by age0.60.63.61.9-1.9-0.6-0.80.7-0.00.10.10.1-0.20.0-0.10.10.4
Bone surface1.12.02.61.0-1.0-1.6-1.51.5-1.61.51.51.5-1.5-1.51.5-1.31.3
Bone volume1.22.12.80.9-0.9-1.7-1.61.5-1.61.51.51.5-1.5-1.51.6-1.21.5
Breakpoint value in progressive ratio session0.30.30.7-0.00.0-0.5-0.50.5-0.60.70.60.6-0.8-0.50.6-0.60.9
Number of licking bursts0.30.41.1-1.11.10.70.7-0.70.4-0.4-0.4-0.40.40.3-0.50.2-0.5
Context. condit. distance diff. score3.44.213.1-3.63.62.32.5-2.41.5-1.3-1.3-1.31.30.8-1.30.6-1.9
Locomotion velocity, session 10.91.01.50.7-0.7-1.1-1.11.1-0.91.11.01.0-1.1-0.71.1-0.71.2
Locomotion distance, session 12.83.67.71.9-1.9-2.0-2.12.2-1.61.81.81.8-1.8-1.01.9-0.92.8
Locomotion velocity, session 21.41.62.51.5-1.5-1.4-1.51.5-1.11.21.21.2-1.2-0.61.2-0.51.6
Locomotion distance, session 24.05.610.02.4-2.4-2.6-2.62.7-2.12.32.32.3-2.3-1.42.3-1.33.2
Locomotion velocity, session 31.61.92.5-0.80.81.51.4-1.41.6-1.5-1.5-1.51.41.4-1.41.3-1.6
Locomotion distance, session 30.70.81.1-1.01.01.01.0-1.01.0-0.8-0.8-0.80.80.8-1.00.7-0.4
Stereotopy head waving bouts, day 30.10.10.40.6-0.6-0.1-0.20.3-0.00.10.10.1-0.10.10.2-0.1-0.3
Stereotopy head waving duration, day 30.40.51.21.1-1.10.30.1-0.10.7-0.7-0.7-0.70.71.0-0.50.9-0.5
Locomotion velocity, session 73.33.614.1-3.73.72.02.2-2.21.0-0.9-0.9-0.91.00.2-1.0-0.0-1.9
Locomotion distance, session 71.31.79.3-3.13.10.71.1-1.0-0.20.20.30.3-0.1-0.90.1-0.9-0.5
Stereotopy head waving bouts, day 70.40.51.41.2-1.20.2-0.00.00.6-0.5-0.6-0.60.41.0-0.40.90.4
Stereotopy head waving duration, day 71.01.22.41.0-1.00.80.6-0.61.3-1.2-1.3-1.31.11.5-1.11.4-0.4
Locomotion velocity, session 80.60.70.9-0.90.91.01.0-0.90.9-0.7-0.7-0.70.70.9-0.80.8-0.1
Locomotion distance, session 80.20.31.2-1.11.10.10.2-0.1-0.10.40.50.5-0.4-0.20.4-0.30.7
Degree of sensitization distance1.41.44.3-2.12.1-0.20.1-0.1-1.10.91.01.0-0.8-1.61.0-1.5-0.2
Degree of sensitization stereotypy0.50.61.30.7-0.70.50.4-0.40.9-0.8-0.9-0.90.71.1-0.81.10.2
Conditioned locomotion0.20.21.2-1.11.10.50.5-0.50.2-0.0-0.0-0.00.2-0.1-0.1-0.2-0.3
Cocaine response after cond. corrected2.32.64.5-2.12.11.81.9-1.91.5-1.4-1.4-1.41.41.1-1.41.0-1.4
Cocaine response after cond. not corrected1.01.12.5-1.61.61.21.3-1.31.0-0.9-0.9-0.90.90.7-0.90.6-0.9
Cocaine response before conditioning2.32.83.71.7-1.7-1.9-1.91.9-1.71.61.71.7-1.7-1.41.7-1.31.3
Saline control response0.81.11.51.2-1.2-1.2-1.21.2-1.11.01.01.0-0.9-0.81.0-0.71.0
Bone: connectivity density1.72.65.6-0.40.4-1.2-1.11.1-1.81.92.01.9-1.8-2.31.9-2.40.6
Bone: cortical apparent density1.82.33.2-1.71.71.61.7-1.81.3-1.5-1.6-1.51.50.9-1.61.0-1.6
Bone: cortical area0.10.20.60.8-0.8-0.4-0.30.3-0.1-0.1-0.2-0.10.10.3-0.20.70.8
Bone: cortical porosity0.50.52.41.6-1.6-0.6-0.70.7-0.10.20.20.1-0.20.20.20.30.6
Bone: cortical porosity0.60.73.01.7-1.7-0.7-0.90.9-0.20.20.20.2-0.20.20.30.30.8
Bone: cortical thickness0.20.31.00.3-0.30.20.2-0.30.4-0.6-0.7-0.60.60.7-0.71.00.2
Bone: cortical thickness0.80.91.3-1.01.00.81.0-1.00.8-1.0-0.9-1.01.00.9-1.01.2-0.7
Bone: cortical tissue density2.12.73.7-1.81.81.81.9-1.91.5-1.7-1.7-1.61.61.1-1.71.1-1.7
Condit. Reinf. active minus inactive responses0.30.31.11.1-1.1-0.7-0.70.7-0.40.30.30.3-0.4-0.20.5-0.20.4
Condit. Reinf. active-inactive response ratio0.20.20.4-0.00.00.50.4-0.40.6-0.5-0.5-0.50.50.6-0.40.4-0.5
Condit. Reinf. active responses1.41.82.61.5-1.5-1.6-1.61.6-1.31.21.21.2-1.3-1.01.4-0.81.1
Condit. Reinf. inactive responses4.14.96.41.7-1.7-2.5-2.52.4-2.42.32.32.3-2.4-2.12.3-1.91.9
Incentive salience index mean0.81.03.51.9-1.9-1.1-1.21.2-0.70.60.50.5-0.6-0.30.7-0.20.9
Condit. Reinf. lever presses1.72.35.82.4-2.4-1.8-1.81.8-1.21.11.01.0-1.2-0.71.2-0.51.6
Condit. Reinf. active minus inactive responses0.50.61.20.5-0.5-0.8-0.80.8-0.80.90.90.9-0.9-0.70.8-0.71.1
Condit. Reinf. active-inactive response ratio0.30.30.5-0.40.40.70.7-0.60.6-0.6-0.5-0.50.60.7-0.70.6-0.4
Condit. Reinf. active responses0.81.11.60.4-0.4-1.1-1.01.1-1.11.21.21.2-1.2-1.11.1-1.01.3
Condit. Reinf. inactive responses2.32.94.00.4-0.4-1.7-1.61.6-1.92.01.91.9-2.0-2.01.9-1.91.4
Condit. Reinf. lever presses0.91.22.71.7-1.7-1.3-1.31.3-1.00.90.90.9-0.8-0.70.8-0.51.2
Condit. Reinf. lever reinforcers received0.50.81.30.5-0.5-0.9-0.90.9-0.91.01.01.0-0.9-0.80.8-0.71.2
Conditioned reinforcement - actives0.30.31.1-1.11.1-0.10.1-0.0-0.50.50.40.4-0.4-0.50.6-0.50.4
Conditioned reinforcement - inactives1.21.42.00.4-0.4-1.2-1.11.1-1.31.41.31.3-1.2-1.31.2-1.41.0
Conditioned locomotion0.10.20.9-0.90.90.30.4-0.3-0.0-0.0-0.0-0.00.00.10.20.00.1
Patch foraging indifference point 0 sec5.99.612.92.9-2.9-3.6-3.63.5-3.23.23.23.1-3.0-2.82.9-2.52.6
Patch foraging indifference point AUC4.55.16.4-1.61.62.42.4-2.32.5-2.2-2.4-2.42.52.5-2.52.4-1.6
Delay disc. indifference point, 0s delay2.62.83.71.3-1.3-1.9-1.91.9-1.81.71.71.7-1.7-1.41.9-1.41.5
Delay disc. indifference point, 16s delay0.30.30.6-0.50.50.40.5-0.50.5-0.7-0.6-0.60.60.6-0.50.8-0.1
Delay disc. indifference point, 2s delay1.51.73.31.8-1.8-1.5-1.61.6-1.11.21.01.0-1.1-0.51.2-0.41.5
Delay disc. indifference point, 24s delay0.50.51.1-0.30.30.50.5-0.50.7-0.9-0.8-0.80.90.9-0.61.0-0.3
Delay disc. indifference point, 4s delay0.60.61.30.3-0.30.50.4-0.50.9-1.0-1.0-1.00.91.0-0.91.1-0.5
Delay disc. indifference point, 8s delay0.30.30.80.0-0.00.30.3-0.40.6-0.7-0.8-0.80.70.5-0.90.80.4
Indifference point function ln k1.82.53.31.6-1.6-1.8-1.81.7-1.61.41.61.6-1.7-1.51.6-1.41.4
Indifference point function log k1.82.53.31.6-1.6-1.8-1.81.7-1.61.41.61.6-1.7-1.51.6-1.41.4
Patch foraging total patch changes 0 sec5.38.511.83.0-3.0-3.4-3.43.4-2.92.93.02.9-2.8-2.52.7-2.22.5
Patch foraging total patch changes 12 sec0.70.91.51.0-1.0-1.2-1.21.2-0.91.01.00.9-0.8-0.60.7-0.51.0
Patch foraging total patch changes 18 sec0.10.10.2-0.10.1-0.5-0.40.4-0.40.40.50.4-0.3-0.40.2-0.20.1
Patch foraging total patch changes 24 sec1.41.73.41.9-1.9-1.6-1.71.6-1.01.21.21.1-0.8-0.70.8-0.51.4
Patch foraging total patch changes 6 sec0.10.20.30.3-0.3-0.6-0.50.5-0.50.50.50.4-0.4-0.40.4-0.30.2
Patch foraging time to switch 0 sec0.81.22.00.0-0.0-1.1-0.90.9-1.31.31.21.2-1.3-1.41.4-1.40.4
Patch foraging water rate 0 sec0.10.20.60.7-0.70.0-0.10.10.4-0.4-0.2-0.30.20.7-0.30.70.1
Patch foraging water rate 12 sec0.20.31.31.1-1.1-0.5-0.60.5-0.2-0.10.10.1-0.20.10.30.20.2
Patch foraging water rate 18 sec2.02.64.80.4-0.41.41.2-1.21.9-2.2-1.9-1.91.92.1-1.82.2-0.8
Patch foraging water rate 24 sec0.81.21.9-1.01.01.21.2-1.21.1-1.4-1.1-1.11.00.9-0.90.9-1.0
Patch foraging water rate 6 sec0.50.72.41.6-1.6-0.0-0.30.20.6-0.8-0.6-0.60.51.0-0.51.20.2
Seeking ratio, delayed vs. immediate footshock2.22.53.51.4-1.4-1.6-1.61.6-1.61.61.61.6-1.9-1.41.9-1.51.5
Distance traveled before self-admin0.30.31.01.0-1.0-0.1-0.10.20.3-0.3-0.3-0.30.30.8-0.10.70.7
Distance traveled after self-admin0.60.61.70.3-0.30.60.5-0.50.9-0.8-0.9-0.90.91.3-0.81.20.2
Extensor digitorum longus weight4.116.231.31.3-1.33.42.9-2.94.8-4.6-4.6-4.64.75.6-4.65.5-1.6
Bone: elastic displacement2.12.43.21.7-1.7-1.7-1.81.8-1.51.51.51.5-1.5-1.11.5-1.11.4
Bone: elastic work3.34.37.62.8-2.8-2.4-2.52.5-1.81.81.91.8-1.8-1.31.8-1.02.1
Bone: endosteal estimation0.20.40.60.8-0.8-0.8-0.80.8-0.70.50.60.5-0.5-0.50.6-0.40.6
Bone: endosteal perimeter1.02.12.91.5-1.5-1.6-1.71.7-1.41.41.41.4-1.4-1.11.5-1.01.7
Epididymis fat weight0.30.71.6-0.50.5-0.6-0.50.6-1.00.90.90.9-0.9-1.31.0-1.20.2
Delta time in closed arm before/after self-admin0.10.10.4-0.10.1-0.1-0.20.2-0.30.40.30.3-0.5-0.40.6-0.6-0.1
Delta time in open arm before/after self-admin0.10.10.5-0.70.70.20.3-0.3-0.10.10.20.20.1-0.4-0.2-0.4-0.1
Diff in mean of infusions in LGA sessions0.20.21.21.1-1.1-0.3-0.40.4-0.0-0.00.00.0-0.2-0.00.1-0.1-0.3
Delay discount exponential model param0.30.31.0-0.30.3-0.2-0.10.2-0.50.70.70.7-0.6-0.70.6-1.0-0.2
Extinction: sum of active levers before priming0.90.91.5-0.40.4-0.7-0.60.6-1.11.11.11.1-1.2-1.21.2-1.20.7
Active lever presses in extinction session 60.20.21.0-1.01.00.30.5-0.4-0.0-0.1-0.2-0.2-0.0-0.0-0.1-0.1-0.7
Bone: final force0.10.10.30.6-0.6-0.2-0.20.2-0.0-0.2-0.2-0.20.20.2-0.20.50.2
Bone: final moment0.20.31.21.1-1.1-0.7-0.70.6-0.40.10.10.1-0.1-0.10.10.30.5
Food consumed during 24 hour testing period0.20.21.21.1-1.1-0.3-0.40.30.1-0.2-0.2-0.20.00.3-0.10.50.5
Glucose1.92.83.6-1.61.61.81.9-1.91.7-1.7-1.7-1.71.81.4-1.81.4-1.4
Heart weight0.00.00.10.3-0.3-0.0-0.10.00.0-0.1-0.0-0.1-0.1-0.10.0-0.1-0.2
Delay discount hyperbolic model param0.30.31.0-0.70.7-0.00.00.0-0.50.60.60.6-0.6-0.70.5-1.0-0.3
Intermittent access intake day 1-15 change0.20.20.50.1-0.1-0.4-0.40.4-0.50.50.50.5-0.4-0.50.7-0.60.3
Intermittent access intake escalation0.00.00.10.1-0.1-0.2-0.20.2-0.30.30.20.2-0.1-0.20.3-0.30.3
Intermittent access intake escalation 20.10.10.20.3-0.3-0.2-0.20.2-0.20.30.20.2-0.1-0.20.4-0.3-0.3
Intermitt. access day 1 inactive lever presses0.30.31.4-0.60.60.10.1-0.1-0.40.40.40.4-0.4-0.50.5-0.9-1.2
Intermitt. access day 15 inactive lever presses0.10.10.50.3-0.30.30.2-0.20.3-0.2-0.3-0.30.20.2-0.20.0-0.7
Intermitt. access escalation Index0.00.00.1-0.10.10.10.1-0.1-0.1-0.0-0.1-0.1-0.10.20.20.20.3
Intermittent access day 1 total infusions1.11.31.7-0.90.91.11.2-1.11.3-1.2-1.2-1.21.21.2-1.31.3-0.3
Intermittent access day 15 total infusions0.50.51.0-1.01.00.80.9-0.90.7-0.6-0.6-0.60.70.6-0.70.5-0.3
Intermittent access terminal intake (last 3 days)1.71.82.3-1.21.21.41.4-1.41.4-1.3-1.4-1.41.51.4-1.51.3-0.8
Intermittent access total infusions1.21.32.6-1.61.61.31.4-1.31.1-1.0-1.0-1.01.00.9-1.10.8-0.7
Intermittent access day 1 locomotion0.10.10.6-0.20.2-0.1-0.10.1-0.10.10.20.2-0.2-0.1-0.1-0.00.8
Intermittent access day 15 total locomotion0.50.51.0-1.01.00.80.8-0.80.7-0.7-0.7-0.70.70.5-0.70.4-0.4
Intermittent access total locomotion0.10.10.2-0.40.40.20.3-0.20.2-0.2-0.2-0.20.20.2-0.30.10.2
Intermittent access standard deviation0.30.30.50.4-0.40.30.2-0.30.6-0.6-0.6-0.60.70.7-0.60.7-0.6
Left kidney weight0.51.32.31.1-1.10.80.6-0.61.3-1.3-1.3-1.31.41.2-1.51.2-1.0
Right kidney weight0.61.74.12.0-2.0-1.4-1.51.5-1.01.01.01.0-1.1-1.01.0-1.00.8
Cocaine induced anxiety1.01.13.71.9-1.9-1.1-1.31.2-0.70.70.70.7-0.7-0.40.5-0.41.0
Post-drug Anxiety2.62.94.80.6-0.6-1.6-1.61.6-1.91.91.91.9-2.0-2.21.7-2.11.3
Baseline Anxiety1.41.52.7-0.40.4-1.0-0.90.9-1.51.41.41.4-1.4-1.61.6-1.50.8
Tail length0.61.92.50.7-0.7-1.5-1.41.4-1.61.41.61.6-1.5-1.61.5-1.50.9
Length with tail0.51.73.81.9-1.9-1.5-1.61.6-1.11.11.11.1-1.1-0.91.0-0.90.8
Length without tail0.40.94.42.1-2.1-0.2-0.50.40.6-0.5-0.6-0.60.60.9-0.70.90.1
Times rat made contact with spout0.10.10.2-0.50.50.40.4-0.40.3-0.3-0.3-0.30.40.3-0.50.3-0.0
Lifetime Intake0.50.61.3-1.11.10.80.9-0.90.7-0.6-0.7-0.70.70.7-0.70.6-0.3
Liver weight, left3.25.17.60.3-0.32.11.8-1.92.6-2.7-2.6-2.72.82.6-2.72.6-1.7
Liver weight, right1.52.44.40.2-0.21.41.2-1.32.0-1.8-1.8-1.81.82.0-1.82.10.0
Locomotor activity2.64.213.33.7-3.7-2.3-2.52.5-1.51.41.21.2-1.3-0.81.3-0.61.7
Locomotor testing distance6.510.814.73.5-3.5-3.8-3.83.8-3.33.23.23.1-3.2-2.73.2-2.52.7
Locomotor testing rearing10.816.721.74.1-4.1-4.6-4.74.6-4.24.14.14.0-4.2-3.54.2-3.43.3
Locomotion in novel chamber0.10.10.3-0.10.10.10.2-0.20.3-0.4-0.3-0.30.40.2-0.50.4-0.0
Locomotion in novel chamber post-restriction0.60.71.80.0-0.00.80.7-0.60.9-0.9-0.8-0.80.91.3-0.81.20.7
Fecal boli incidents, locomotor time 11.31.42.60.4-0.40.70.7-0.81.2-1.5-1.6-1.51.41.3-1.61.6-1.1
Change in fecal boli incidents, locomotor task0.20.20.7-0.70.70.30.3-0.3-0.10.10.30.1-0.2-0.40.3-0.6-0.9
Time >=10cm from walls, locomotor time 11.11.11.70.6-0.6-1.1-1.11.1-1.21.21.31.3-0.9-1.30.6-1.30.8
Bouts of movement, locomotor time 10.70.81.6-0.30.31.00.9-0.81.0-1.0-0.9-0.90.81.3-0.81.0-0.7
Total resting periods, locomotor time 11.71.92.8-1.01.01.61.5-1.51.5-1.4-1.4-1.41.21.7-1.21.4-1.1
Rest time, locomotor task time 12.02.23.2-1.11.11.71.7-1.61.6-1.7-1.4-1.41.51.8-1.41.6-1.1
Distance moved, locomotor task time 11.41.52.40.6-0.6-1.4-1.31.2-1.41.41.31.3-1.2-1.61.0-1.40.9
Vertical activity count, locomotor time 12.42.65.32.3-2.3-1.8-1.91.9-1.31.41.21.2-1.2-0.91.1-0.72.0
Time >=10cm from walls, locomotor time 20.00.10.20.4-0.4-0.0-0.10.10.1-0.1-0.2-0.00.20.1-0.30.1-0.4
Bouts of movement, locomotor time 21.41.52.0-0.90.91.41.4-1.41.4-1.4-1.4-1.31.01.3-1.01.3-1.0
Total resting periods, locomotor time 23.23.44.5-1.41.42.12.0-2.02.1-2.1-2.1-2.01.61.9-1.61.9-1.6
Rest time, locomotor task time 28.69.913.1-2.02.03.33.3-3.33.5-3.6-3.3-3.43.43.3-3.33.4-2.3
Distance moved, locomotor task time 24.55.26.61.8-1.8-2.6-2.52.5-2.42.62.32.4-2.2-2.32.0-2.12.1
Vertical activity count, locomotor time 24.24.67.52.7-2.7-2.5-2.52.5-1.92.01.71.9-1.8-1.41.7-1.12.7
Light reinforcement 10.30.51.3-0.70.7-0.5-0.30.2-0.70.70.60.6-0.8-1.10.8-1.00.5
Light reinforcement 21.51.94.5-2.12.11.61.7-1.71.1-1.2-1.2-1.21.10.6-1.00.6-1.1
Bone: marrow area0.20.50.70.8-0.8-0.8-0.80.8-0.70.60.70.6-0.6-0.60.7-0.40.7
Bone: maximum diameter0.20.41.40.5-0.50.30.3-0.20.6-0.7-0.6-0.60.71.0-0.71.20.3
Bone: maximum force0.20.41.51.2-1.2-0.5-0.50.5-0.1-0.2-0.2-0.20.10.4-0.20.80.9
Bone: maximum moment0.50.83.01.7-1.7-1.0-1.01.0-0.50.20.20.2-0.20.00.20.51.2
Mean time between licks in bursts2.43.46.1-0.20.2-1.6-1.41.4-1.92.22.22.2-2.0-2.42.2-2.51.3
Mean num. licks in bursts0.10.10.40.6-0.6-0.3-0.30.3-0.10.10.10.1-0.10.00.10.10.4
Cd content in liver0.10.20.40.2-0.2-0.4-0.40.3-0.50.40.40.4-0.4-0.60.4-0.5-0.2
Co content in liver2.12.43.8-0.70.71.61.6-1.51.8-1.6-1.7-1.71.71.9-1.71.9-0.5
Cu content in liver0.91.11.5-0.30.31.11.0-1.01.2-1.1-1.2-1.21.21.2-1.21.1-0.9
Fe content in liver0.30.31.0-0.60.6-0.1-0.10.1-0.50.50.50.5-0.5-0.80.5-1.0-0.7
K content in liver0.20.20.5-0.70.7-0.1-0.00.1-0.40.40.50.5-0.5-0.50.5-0.60.3
Mg content in liver0.20.20.4-0.60.6-0.1-0.00.1-0.30.40.50.5-0.5-0.40.5-0.50.5
Mn content in liver1.72.02.9-0.20.2-1.2-1.11.2-1.61.61.71.7-1.7-1.61.7-1.61.4
Na content in liver2.22.49.73.1-3.1-1.5-1.81.8-0.70.60.70.7-0.70.00.70.11.5
Rb content in liver0.50.61.6-1.31.30.80.9-0.90.4-0.5-0.4-0.40.50.0-0.4-0.1-1.2
Se content in liver4.96.07.32.1-2.1-2.6-2.72.7-2.42.62.52.5-2.5-2.22.5-2.22.2
Sr content in liver0.90.81.40.0-0.0-0.7-0.70.8-0.91.11.11.1-1.1-1.01.1-1.20.6
Zn content in liver0.80.93.81.9-1.9-0.9-1.01.0-0.30.40.40.4-0.4-0.00.40.01.1
Bone: minimum diameter0.50.93.01.7-1.7-1.0-1.11.1-0.60.30.30.3-0.30.00.40.31.3
Time in familiar zone, hab. session 10.10.10.2-0.40.4-0.2-0.10.1-0.40.20.30.3-0.3-0.20.4-0.10.1
Time in novel zone, hab. session 12.12.02.9-0.40.41.41.3-1.41.7-1.6-1.7-1.71.71.5-1.71.5-1.3
Total zone transitions, hab. session 10.60.82.51.3-1.3-1.0-1.01.0-0.50.50.60.6-0.50.00.50.21.6
Total locomotion distance, hab. session 11.52.24.21.5-1.5-1.7-1.71.7-1.41.41.41.4-1.4-0.91.5-0.72.0
Locomotion velocity, hab. session 13.55.08.42.2-2.2-2.5-2.52.5-2.22.12.22.2-2.2-1.52.2-1.42.9
Time in familiar zone, hab. session 20.91.02.0-1.41.41.11.2-1.20.8-0.8-0.8-0.80.80.5-0.90.5-0.9
Time in novel zone, hab. session 20.60.61.31.1-1.1-0.9-0.90.9-0.60.60.60.6-0.6-0.40.8-0.30.9
Total zone transitions, hab. session 20.71.03.31.8-1.8-1.0-1.11.1-0.40.50.50.5-0.50.20.50.31.4
Total locomotion distance, hab. session 20.60.81.51.2-1.2-1.0-1.01.1-0.70.70.70.7-0.8-0.20.9-0.11.1
Locomotion velocity, hab. session 20.71.02.51.6-1.6-1.1-1.21.2-0.60.70.70.7-0.8-0.10.80.01.4
Novel to familiar place preference ratio0.80.81.30.9-0.9-1.1-1.11.0-1.00.80.80.8-0.8-0.80.7-0.51.1
Novelty place preference1.01.01.61.0-1.0-1.3-1.21.1-1.10.91.01.0-1.0-1.00.8-0.71.2
Time in novel zone, NPP test1.01.11.61.1-1.1-1.2-1.21.2-1.10.91.01.0-1.0-0.90.8-0.71.3
Total zone transitions, NPP test1.92.74.51.3-1.3-1.8-1.81.9-1.61.71.71.7-1.7-1.11.7-1.12.1
Total locomotion distance, NPP test5.37.39.51.2-1.2-2.8-2.72.8-3.03.03.03.0-3.1-2.63.1-2.62.7
Locomotion velocity, NPP test4.05.77.41.0-1.0-2.5-2.42.5-2.72.72.72.7-2.7-2.42.7-2.32.3
Intraocular pressure1.21.72.60.3-0.3-1.3-1.21.2-1.41.61.51.5-1.5-1.51.5-1.51.2
Delta distance traveled before/after self-admin1.01.11.6-0.60.61.11.1-1.01.1-1.1-1.1-1.11.11.1-1.01.0-1.3
Delta ambulatory time before/after self-admin0.70.71.2-0.30.30.80.8-0.80.9-0.9-1.0-1.00.91.0-0.81.0-1.1
Parametrial fat weight1.42.74.7-1.21.2-1.3-1.01.1-1.91.81.91.9-1.8-2.21.8-2.01.2
Pavlov. Cond. lever latency0.40.51.9-1.41.40.90.9-0.80.6-0.4-0.3-0.30.60.3-0.60.2-0.3
Pavlov. Cond. magazine entry latency0.00.00.30.3-0.30.0-0.0-0.00.0-0.1-0.2-0.20.0-0.10.0-0.0-0.5
Pavlov. Cond. change in total contacts0.70.84.12.0-2.0-0.5-0.70.60.1-0.3-0.4-0.40.20.6-0.10.80.5
Pavlov. Cond. index score0.20.21.41.2-1.2-0.3-0.40.4-0.0-0.1-0.2-0.2-0.00.20.10.3-0.1
Pavlov. Cond. latency score0.20.31.51.2-1.2-0.5-0.60.5-0.20.0-0.0-0.0-0.2-0.00.30.1-0.1
Pavlov. Cond. lever contacts0.20.31.41.2-1.2-0.5-0.60.5-0.20.10.00.0-0.2-0.00.30.0-0.1
Pavlov. Cond. magazine entry number0.20.30.6-0.80.8-0.2-0.10.1-0.50.50.60.6-0.5-0.60.4-0.60.3
Pavlov. Cond. intertrial magazine entries1.61.92.61.3-1.3-1.6-1.61.6-1.41.41.41.4-1.3-1.21.4-1.01.3
Pavlov. Cond. lever-magazine prob. diff.0.20.31.31.2-1.2-0.1-0.30.20.2-0.3-0.4-0.40.20.4-0.10.5-0.2
Pavlov. Cond. response bias0.30.40.70.7-0.70.40.3-0.30.6-0.8-0.8-0.80.70.7-0.60.8-0.6
Pavlov. Cond. lever latency0.30.42.2-1.51.50.20.4-0.3-0.30.30.30.3-0.3-0.50.3-0.60.1
Pavlov. Cond. magazine entry latency0.30.31.31.1-1.1-0.6-0.70.6-0.20.20.20.2-0.2-0.10.3-0.00.4
Pavlov. Cond. change in total contacts0.60.92.61.6-1.60.2-0.10.00.9-0.8-0.8-0.80.91.1-0.91.20.2
Pavlov. Cond. index score0.40.52.91.7-1.7-0.5-0.70.60.1-0.1-0.1-0.10.10.4-0.00.40.5
Pavlov. Cond. latency score0.50.63.11.8-1.8-0.7-0.90.8-0.20.20.20.2-0.20.00.30.10.6
Pavlov. Cond. lever contacts0.60.84.12.0-2.0-0.8-0.90.9-0.10.10.10.1-0.10.20.10.40.7
Pavlov. Cond. magazine entry number0.50.61.2-1.11.10.90.9-0.90.6-0.6-0.5-0.50.50.4-0.70.3-0.9
Pavlov. Cond. intertrial magazine entries4.25.48.6-0.30.3-2.1-1.81.9-2.82.72.72.7-2.8-2.92.7-2.91.5
Pavlov. Cond. lever-magazine prob. diff.0.40.52.41.6-1.6-0.3-0.50.50.2-0.2-0.2-0.20.30.5-0.10.50.5
Pavlov. Cond. response bias0.70.94.52.1-2.1-0.8-1.01.0-0.20.10.10.1-0.20.30.20.40.8
Time in closed arm before self-admin0.20.30.5-0.00.00.50.4-0.40.7-0.6-0.5-0.50.70.6-0.70.6-0.2
Time in closed arm after self-admin0.10.10.20.4-0.4-0.3-0.40.4-0.20.20.20.2-0.4-0.20.3-0.30.1
Time in open arm before self-admin0.40.40.80.6-0.6-0.7-0.70.7-0.60.50.50.5-0.7-0.40.7-0.20.9
Time in open arm after self-admin0.10.10.5-0.70.70.10.2-0.2-0.20.20.20.2-0.1-0.40.2-0.4-0.1
Bone: periosteal estimation0.20.30.80.9-0.9-0.7-0.70.7-0.50.30.30.3-0.3-0.20.30.10.8
Bone: periosteal perimeter0.61.01.81.1-1.1-1.2-1.11.2-0.90.90.90.9-0.9-0.60.9-0.41.3
Bone: post-yield work1.82.43.2-1.61.61.51.7-1.71.4-1.7-1.7-1.71.61.4-1.61.8-0.5
Progressive ratio test 1 active lever presses3.13.24.1-1.81.81.92.0-2.01.8-1.8-1.8-1.81.81.7-2.01.7-1.1
Progressive ratio test 1 breakpoint3.33.44.4-1.91.92.02.1-2.11.8-1.8-1.8-1.81.81.6-2.01.7-1.2
Progressive ratio test 1 inactive lever presses0.20.20.3-0.60.6-0.10.00.0-0.50.40.30.3-0.4-0.60.4-0.6-0.3
Progressive ratio test 2 active lever presses2.32.53.1-1.61.61.71.7-1.71.6-1.7-1.6-1.61.61.4-1.51.3-1.3
Progressive ratio test 2 breakpoint1.82.02.5-1.31.31.51.5-1.51.5-1.6-1.5-1.51.51.3-1.41.3-1.1
Progressive ratio test 2 inactive lever presses0.20.30.4-0.50.50.60.6-0.60.5-0.5-0.5-0.50.50.5-0.50.3-0.6
Incentive Sensitization - Responses0.20.20.40.2-0.20.20.2-0.20.5-0.6-0.5-0.50.50.6-0.40.4-0.1
Incentive Sensitization - Breakpoint0.10.10.20.2-0.20.10.1-0.10.4-0.5-0.4-0.40.30.4-0.20.3-0.0
Sum of active levers in priming session hrs 5-60.50.52.6-1.61.60.60.7-0.70.1-0.2-0.2-0.20.0-0.20.0-0.2-0.5
Progressive ratio0.20.20.50.7-0.70.20.1-0.00.4-0.6-0.4-0.40.40.6-0.40.6-0.1
Food seeking constrained by brief footshock3.03.75.6-2.42.42.42.4-2.31.9-1.7-1.7-1.71.61.6-1.41.2-1.8
Seeking ratio, punishment vs. effort0.91.12.7-1.61.61.21.2-1.21.0-0.7-0.8-0.80.70.6-0.70.4-0.8
Retroperitoneal fat weight0.10.31.5-1.21.20.00.2-0.2-0.40.30.30.3-0.4-0.60.4-0.6-0.1
Reaction time number correct0.10.20.5-0.70.70.50.6-0.60.3-0.5-0.3-0.30.20.2-0.10.1-0.7
Reaction time mean minus median0.30.40.80.9-0.9-0.6-0.70.7-0.40.60.50.5-0.7-0.50.6-0.50.7
Reaction time mean minus median AUC0.10.20.30.6-0.6-0.4-0.40.4-0.30.40.30.3-0.5-0.40.5-0.40.3
Reaction time num false alarms0.60.81.10.9-0.9-1.1-1.11.1-1.00.90.90.8-0.9-0.71.0-0.60.9
Reaction time num false alarms AUC0.30.40.70.8-0.8-0.8-0.80.7-0.70.40.40.4-0.5-0.30.6-0.20.6
Reaction time trials correct on left0.10.20.5-0.70.70.50.6-0.60.3-0.5-0.3-0.30.20.2-0.10.1-0.7
Reaction time trials on left0.10.20.5-0.70.70.50.5-0.50.2-0.4-0.3-0.30.10.1-0.00.0-0.7
Reaction time mean0.00.00.10.3-0.30.20.1-0.10.20.0-0.2-0.20.00.00.1-0.10.2
Reaction time mean AUC0.10.10.50.7-0.7-0.0-0.20.20.00.1-0.1-0.1-0.1-0.00.2-0.20.4
Median of all reaction times0.10.10.30.1-0.10.50.4-0.40.4-0.3-0.5-0.50.20.2-0.10.1-0.1
Reaction time omissions1.21.73.4-0.00.0-1.1-1.00.9-1.51.51.41.4-1.5-1.91.5-1.81.0
Reaction time false alarm rate0.20.30.50.7-0.7-0.7-0.70.7-0.60.50.40.4-0.4-0.30.5-0.20.7
Reaction time premature initiation rate0.40.50.9-0.20.20.80.7-0.60.9-0.7-0.7-0.70.71.0-0.80.8-0.1
Reaction time premature initiations0.60.81.2-0.50.51.11.0-1.01.1-1.0-1.0-0.90.81.0-0.90.9-0.5
Std. dev. reaction times0.00.00.10.2-0.20.0-0.00.00.10.1-0.1-0.0-0.2-0.10.2-0.10.2
Reaction time trials completed0.10.20.5-0.70.70.50.5-0.50.2-0.4-0.3-0.30.10.1-0.00.0-0.7
Reaction time trials AUC0.10.20.6-0.70.70.50.5-0.50.2-0.4-0.3-0.30.20.1-0.00.0-0.8
Run reversals in cocaine runway, females0.30.30.5-0.60.6-0.3-0.20.3-0.50.70.70.7-0.6-0.60.5-0.60.6
Run reversals in cocaine runway, males3.63.57.60.9-0.91.51.3-1.22.0-2.2-2.1-2.12.02.8-2.12.7-0.7
Latency to leave start box in cocaine runway0.60.71.50.2-0.20.90.8-0.71.1-1.0-0.8-0.80.81.2-0.61.0-0.1
Latency to leave start box in cocaine runway, F1.21.32.70.7-0.71.00.9-0.81.3-1.4-1.3-1.31.31.6-1.01.4-0.9
Latency to leave start box in cocaine runway, M0.70.72.30.0-0.0-0.5-0.50.6-0.60.71.01.0-0.9-0.90.9-1.01.5
Std. dev. time between licks in bursts7.99.411.61.7-1.7-3.2-3.23.2-3.23.43.43.4-3.3-3.23.2-3.13.2
Total sessions with >9 infusions0.20.20.8-0.90.90.10.2-0.1-0.30.30.30.3-0.3-0.40.3-0.50.2
Short access day 1 total inactive lever presses1.82.02.5-1.41.41.61.6-1.51.5-1.4-1.4-1.41.51.4-1.51.3-1.0
Short access day 10 total inactive lever presses0.20.20.5-0.70.70.10.2-0.2-0.40.30.30.3-0.3-0.40.4-0.6-0.2
Short access day 1 total infusions1.11.21.9-1.41.41.31.3-1.20.9-0.9-0.9-0.91.00.9-0.90.6-1.2
Short access day 10 total infusions0.30.41.10.4-0.40.10.1-0.10.6-0.5-0.5-0.50.50.9-0.61.11.1
Short access total infusions0.20.30.4-0.40.40.50.5-0.50.5-0.5-0.5-0.50.50.6-0.60.6-0.1
Short access day 1 locomotion0.10.20.80.9-0.9-0.3-0.40.4-0.10.10.10.1-0.10.10.20.00.2
Short access day 10 total locomotion0.50.50.70.3-0.3-0.7-0.70.8-0.90.80.80.8-0.8-0.80.8-0.90.7
Short access total locomotion0.60.70.80.4-0.4-0.8-0.80.8-0.90.90.90.9-0.9-0.80.7-0.90.9
One hour access (0.3 mA shock)0.20.20.5-0.40.40.30.4-0.40.6-0.5-0.5-0.50.50.6-0.40.70.4
Compulsive drug intake0.60.60.90.5-0.5-0.9-0.80.8-0.80.80.80.8-1.0-0.60.8-0.51.0
One hour access (shock baseline)0.70.81.1-0.80.80.90.9-0.91.0-0.9-0.9-0.91.01.0-0.80.9-0.3
Social response proportion1.21.34.5-2.12.11.31.4-1.40.7-0.7-0.6-0.70.50.2-0.4-0.0-1.4
Social responses2.32.95.6-0.90.9-1.2-1.11.1-1.91.82.01.9-2.1-2.32.2-2.40.7
Social time1.21.51.91.2-1.2-1.4-1.41.3-1.31.31.31.3-1.2-1.21.3-1.20.7
Soleus weight0.41.32.1-0.40.41.11.1-1.11.3-1.2-1.2-1.21.31.4-1.21.4-0.4
Bone: stiffness0.30.51.00.1-0.10.50.5-0.50.7-0.8-0.8-0.80.80.9-0.81.0-0.0
Tibialis anterior weight2.68.817.91.5-1.52.31.9-1.93.5-3.4-3.4-3.43.44.2-3.34.2-1.1
Time to tail flick, vehicle, before self-admin0.20.20.30.5-0.5-0.5-0.50.5-0.50.30.50.5-0.2-0.50.2-0.3-0.3
Time to tail flick, vehicle, after self-admin1.01.01.5-0.50.51.21.1-1.11.2-1.1-1.0-1.01.21.2-1.11.1-0.6
Time to tail flick, test, before self-admin0.60.61.80.4-0.4-0.9-0.80.9-0.70.90.80.8-0.5-0.70.5-0.51.3
Time to tail flick, test, after self-admin1.71.86.0-2.52.5-0.10.1-0.1-1.01.11.21.2-0.9-1.80.9-1.80.1
Delta time to tail flick, vehicle, before/after SA1.31.31.8-1.31.31.31.3-1.31.2-1.1-1.1-1.11.10.9-1.10.8-0.8
Delta time to tail flick, test, before/after SA1.61.46.5-2.62.61.11.3-1.30.3-0.3-0.2-0.20.2-0.3-0.2-0.5-1.3
Tibia length2.57.29.83.0-3.0-3.1-3.13.1-2.82.62.52.5-2.6-2.42.5-2.31.8
Ambulatory time before self-admin0.20.20.60.8-0.8-0.1-0.10.20.2-0.3-0.3-0.30.30.7-0.20.70.5
Ambulatory time after self-admin0.70.82.30.5-0.50.60.5-0.41.0-1.0-1.0-1.00.91.5-0.81.40.1
Bone: tissue strength0.60.61.10.8-0.8-0.9-0.90.9-0.70.70.60.6-0.7-0.60.6-0.41.0
Total heroin consumption0.70.91.61.1-1.10.40.3-0.40.8-1.0-1.1-1.11.01.2-1.01.3-0.6
Bone: trabecular number1.32.03.5-0.10.1-1.3-1.21.2-1.71.61.71.7-1.6-1.91.6-1.80.9
Bone: trabecular spacing0.91.22.80.3-0.30.90.8-0.81.3-1.2-1.3-1.21.21.7-1.21.6-0.1
Bone: trabecular thickness0.50.61.10.6-0.6-1.0-0.90.9-0.90.70.80.7-0.8-0.80.7-0.51.1
Bone: trabecular tissue density0.40.51.10.4-0.40.50.4-0.50.8-0.9-0.9-0.90.90.9-0.91.0-0.4
Water consumed over 24 hours0.30.30.80.8-0.80.20.1-0.10.6-0.5-0.5-0.50.40.9-0.50.90.7
Number of responses in last shaping day0.50.52.01.4-1.4-0.8-0.90.8-0.30.30.40.4-0.4-0.20.5-0.10.6