Hub : Genes

Ccdc150

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Ccdc150 0.03 0.02 4.0e-03 0.01 0.01 0.02 0.01 9.0e-03 7.2e-03 5.7e-03 9.8e-03
2 Brain gene expression Ccdc150 0.03 0.02 8.5e-03 0 0.01 0 0 1.6e-01 1.3e-02 3.2e-01 1.8e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density5.49.010.23.2-2.8
Area under the delay curve0.00.00.1-0.2-0.1
BMI with tail2.06.39.4-3.11.8
BMI without tail0.51.11.5-0.91.2
Body weight0.62.74.42.1-1.0
Weight adjusted by age1.11.31.41.2-1.1
Bone surface5.08.910.73.3-2.7
Bone volume6.110.311.23.4-3.1
Breakpoint value in progressive ratio session0.40.40.50.7-0.6
Number of licking bursts0.10.10.2-0.4-0.3
Context. condit. distance diff. score2.22.73.1-1.51.8
Locomotion velocity, session 12.32.53.8-1.91.1
Locomotion distance, session 10.81.01.3-1.10.9
Locomotion velocity, session 21.41.62.5-1.60.9
Locomotion distance, session 20.30.40.5-0.70.5
Locomotion velocity, session 30.40.50.9-0.31.0
Locomotion distance, session 30.20.20.3-0.30.5
Stereotopy head waving bouts, day 32.63.03.0-1.71.7
Stereotopy head waving duration, day 31.11.41.8-1.01.4
Locomotion velocity, session 71.71.92.8-1.70.9
Locomotion distance, session 70.00.10.1-0.30.1
Stereotopy head waving bouts, day 70.00.00.0-0.0-0.1
Stereotopy head waving duration, day 70.20.20.2-0.40.5
Locomotion velocity, session 80.60.71.3-1.20.1
Locomotion distance, session 82.02.93.0-1.71.7
Degree of sensitization distance0.50.50.80.4-0.9
Degree of sensitization stereotypy0.30.30.40.4-0.7
Conditioned locomotion2.53.03.41.8-1.6
Cocaine response after cond. corrected4.65.16.71.9-2.6
Cocaine response after cond. not corrected5.15.66.82.1-2.6
Cocaine response before conditioning0.40.40.6-0.50.8
Saline control response0.30.40.7-0.40.8
Bone: connectivity density2.64.14.42.1-2.0
Bone: cortical apparent density3.74.97.2-2.71.6
Bone: cortical area0.20.30.30.6-0.5
Bone: cortical porosity2.02.23.71.9-0.8
Bone: cortical porosity3.63.96.32.5-1.3
Bone: cortical thickness0.71.21.7-1.30.8
Bone: cortical thickness0.40.40.8-0.9-0.2
Bone: cortical tissue density3.85.17.4-2.71.7
Condit. Reinf. active minus inactive responses1.61.82.41.1-1.5
Condit. Reinf. active-inactive response ratio0.40.40.70.3-0.8
Condit. Reinf. active responses3.23.94.41.9-2.1
Condit. Reinf. inactive responses1.31.51.61.3-1.2
Incentive salience index mean2.73.34.31.5-2.1
Condit. Reinf. lever presses1.52.02.31.3-1.5
Condit. Reinf. active minus inactive responses7.79.59.93.0-3.1
Condit. Reinf. active-inactive response ratio3.84.05.31.6-2.3
Condit. Reinf. active responses5.37.48.32.6-2.9
Condit. Reinf. inactive responses0.20.30.30.5-0.6
Condit. Reinf. lever presses0.91.22.40.3-1.5
Condit. Reinf. lever reinforcers received5.47.69.22.5-3.0
Conditioned reinforcement - actives0.40.40.7-0.40.8
Conditioned reinforcement - inactives0.00.00.0-0.10.2
Conditioned locomotion0.00.00.0-0.1-0.1
Patch foraging indifference point 0 sec0.30.50.6-0.7-0.8
Patch foraging indifference point AUC0.10.10.20.4-0.3
Delay disc. indifference point, 0s delay1.11.21.9-1.40.7
Delay disc. indifference point, 16s delay0.00.00.1-0.1-0.3
Delay disc. indifference point, 2s delay0.30.40.7-0.3-0.8
Delay disc. indifference point, 24s delay0.60.60.6-0.80.8
Delay disc. indifference point, 4s delay0.60.71.1-1.00.5
Delay disc. indifference point, 8s delay0.00.00.10.2-0.1
Indifference point function ln k0.30.40.8-0.9-0.3
Indifference point function log k0.30.40.8-0.9-0.3
Patch foraging total patch changes 0 sec0.30.50.6-0.7-0.8
Patch foraging total patch changes 12 sec0.40.61.10.1-1.1
Patch foraging total patch changes 18 sec1.31.72.8-1.70.7
Patch foraging total patch changes 24 sec0.00.00.0-0.0-0.0
Patch foraging total patch changes 6 sec0.10.20.3-0.5-0.3
Patch foraging time to switch 0 sec0.50.81.4-0.51.2
Patch foraging water rate 0 sec0.40.60.70.8-0.7
Patch foraging water rate 12 sec0.71.02.00.1-1.4
Patch foraging water rate 18 sec1.41.92.31.2-1.5
Patch foraging water rate 24 sec0.00.00.00.10.2
Patch foraging water rate 6 sec0.30.40.50.7-0.5
Seeking ratio, delayed vs. immediate footshock1.82.02.61.6-1.2
Distance traveled before self-admin2.52.72.91.7-1.6
Distance traveled after self-admin0.00.00.1-0.1-0.3
Extensor digitorum longus weight2.59.810.4-3.03.2
Bone: elastic displacement0.30.30.60.1-0.8
Bone: elastic work2.02.52.71.5-1.6
Bone: endosteal estimation4.49.612.03.5-2.7
Bone: endosteal perimeter3.36.88.83.0-2.2
Epididymis fat weight1.12.74.72.2-0.8
Delta time in closed arm before/after self-admin1.61.62.1-1.11.4
Delta time in open arm before/after self-admin6.56.36.62.6-2.4
Diff in mean of infusions in LGA sessions0.80.91.00.8-1.0
Delay discount exponential model param0.00.00.10.20.2
Extinction: sum of active levers before priming1.81.72.31.5-1.1
Active lever presses in extinction session 61.51.51.51.2-1.2
Bone: final force1.32.13.81.9-0.7
Bone: final moment1.01.63.01.7-0.5
Food consumed during 24 hour testing period0.00.00.10.3-0.1
Glucose0.91.32.4-0.51.5
Heart weight0.30.50.80.4-0.9
Delay discount hyperbolic model param0.10.10.10.40.1
Intermittent access intake day 1-15 change0.30.30.3-0.50.6
Intermittent access intake escalation0.20.20.2-0.40.4
Intermittent access intake escalation 20.10.10.10.4-0.2
Intermitt. access day 1 inactive lever presses1.21.21.3-1.11.1
Intermitt. access day 15 inactive lever presses0.10.10.1-0.30.2
Intermitt. access escalation Index0.30.30.40.60.4
Intermittent access day 1 total infusions1.21.42.01.4-0.9
Intermittent access day 15 total infusions0.40.40.80.9-0.3
Intermittent access terminal intake (last 3 days)0.30.40.50.7-0.4
Intermittent access total infusions1.01.11.81.3-0.7
Intermittent access day 1 locomotion0.00.10.10.2-0.2
Intermittent access day 15 total locomotion0.80.91.01.0-0.8
Intermittent access total locomotion0.30.30.60.7-0.4
Intermittent access standard deviation0.00.00.00.20.2
Left kidney weight0.30.70.90.7-1.0
Right kidney weight0.30.91.20.7-1.1
Cocaine induced anxiety0.00.00.0-0.10.2
Post-drug Anxiety0.00.00.10.1-0.3
Baseline Anxiety0.20.20.20.4-0.5
Tail length4.714.123.84.9-2.1
Length with tail5.921.533.95.8-3.0
Length without tail1.32.93.71.9-1.5
Times rat made contact with spout0.10.10.2-0.20.5
Lifetime Intake0.30.30.50.7-0.2
Liver weight, left0.91.41.91.4-0.9
Liver weight, right0.61.01.31.1-0.8
Locomotor activity0.10.20.40.6-0.3
Locomotor testing distance0.20.40.60.5-0.8
Locomotor testing rearing0.20.30.50.7-0.2
Locomotion in novel chamber0.40.50.7-0.80.5
Locomotion in novel chamber post-restriction1.31.52.0-1.41.0
Fecal boli incidents, locomotor time 12.52.72.81.7-1.6
Change in fecal boli incidents, locomotor task0.10.10.1-0.30.3
Time >=10cm from walls, locomotor time 10.91.01.80.3-1.4
Bouts of movement, locomotor time 10.20.30.50.2-0.7
Total resting periods, locomotor time 10.20.20.2-0.5-0.4
Rest time, locomotor task time 10.10.10.1-0.30.2
Distance moved, locomotor task time 10.20.20.40.3-0.6
Vertical activity count, locomotor time 10.80.81.2-0.61.1
Time >=10cm from walls, locomotor time 23.63.95.81.4-2.4
Bouts of movement, locomotor time 20.30.30.3-0.6-0.6
Total resting periods, locomotor time 20.30.30.4-0.5-0.6
Rest time, locomotor task time 20.40.50.7-0.50.8
Distance moved, locomotor task time 20.60.61.20.2-1.1
Vertical activity count, locomotor time 20.10.10.3-0.50.1
Light reinforcement 10.50.81.2-1.10.7
Light reinforcement 21.21.62.70.7-1.6
Bone: marrow area4.19.011.13.3-2.6
Bone: maximum diameter0.71.21.41.2-1.0
Bone: maximum force2.23.86.02.4-1.3
Bone: maximum moment1.83.15.02.2-1.1
Mean time between licks in bursts1.11.62.1-1.01.5
Mean num. licks in bursts0.10.10.20.20.4
Cd content in liver0.40.40.80.20.9
Co content in liver1.21.41.6-1.11.3
Cu content in liver0.40.50.70.5-0.8
Fe content in liver2.73.34.12.0-1.6
K content in liver0.00.00.00.0-0.2
Mg content in liver0.40.40.40.7-0.7
Mn content in liver1.31.51.8-1.41.0
Na content in liver1.41.51.81.1-1.3
Rb content in liver1.51.92.41.2-1.5
Se content in liver0.60.70.80.9-0.8
Sr content in liver0.70.61.3-0.11.1
Zn content in liver0.10.10.1-0.20.4
Bone: minimum diameter1.01.82.21.5-1.2
Time in familiar zone, hab. session 10.90.81.3-0.71.1
Time in novel zone, hab. session 10.70.71.00.5-1.0
Total zone transitions, hab. session 10.10.20.3-0.6-0.2
Total locomotion distance, hab. session 11.01.42.30.7-1.5
Locomotion velocity, hab. session 10.81.21.50.9-1.2
Time in familiar zone, hab. session 20.70.71.3-1.20.3
Time in novel zone, hab. session 20.50.50.91.0-0.2
Total zone transitions, hab. session 20.30.40.6-0.40.8
Total locomotion distance, hab. session 20.10.10.30.5-0.1
Locomotion velocity, hab. session 20.10.10.20.50.1
Novel to familiar place preference ratio3.83.94.82.2-1.7
Novelty place preference3.63.64.62.1-1.6
Time in novel zone, NPP test3.33.44.12.0-1.6
Total zone transitions, NPP test0.10.20.2-0.50.4
Total locomotion distance, NPP test0.10.20.40.2-0.6
Locomotion velocity, NPP test0.00.10.10.1-0.3
Intraocular pressure2.53.55.2-2.31.3
Delta distance traveled before/after self-admin0.70.81.0-1.00.7
Delta ambulatory time before/after self-admin0.20.20.3-0.50.4
Parametrial fat weight0.00.00.0-0.0-0.0
Pavlov. Cond. lever latency2.22.73.7-1.31.9
Pavlov. Cond. magazine entry latency1.82.33.51.1-1.9
Pavlov. Cond. change in total contacts2.12.23.80.8-1.9
Pavlov. Cond. index score2.12.73.71.3-1.9
Pavlov. Cond. latency score2.83.64.61.6-2.1
Pavlov. Cond. lever contacts2.32.73.51.4-1.9
Pavlov. Cond. magazine entry number1.82.23.3-1.11.8
Pavlov. Cond. intertrial magazine entries0.60.81.41.2-0.3
Pavlov. Cond. lever-magazine prob. diff.1.72.23.21.1-1.8
Pavlov. Cond. response bias1.41.72.41.0-1.6
Pavlov. Cond. lever latency0.30.40.50.60.7
Pavlov. Cond. magazine entry latency0.60.71.0-1.00.6
Pavlov. Cond. change in total contacts0.71.02.0-0.1-1.4
Pavlov. Cond. index score0.30.30.5-0.4-0.7
Pavlov. Cond. latency score0.20.30.5-0.4-0.7
Pavlov. Cond. lever contacts0.70.91.80.0-1.3
Pavlov. Cond. magazine entry number0.20.20.4-0.20.6
Pavlov. Cond. intertrial magazine entries0.10.10.20.4-0.3
Pavlov. Cond. lever-magazine prob. diff.0.30.30.5-0.4-0.7
Pavlov. Cond. response bias0.50.71.40.1-1.2
Time in closed arm before self-admin4.85.46.52.5-2.1
Time in closed arm after self-admin0.90.91.20.8-1.1
Time in open arm before self-admin5.66.16.6-2.42.6
Time in open arm after self-admin0.60.60.90.9-0.7
Bone: periosteal estimation2.85.87.32.7-2.1
Bone: periosteal perimeter2.13.64.52.1-1.6
Bone: post-yield work0.71.01.81.3-0.5
Progressive ratio test 1 active lever presses0.10.10.20.10.5
Progressive ratio test 1 breakpoint0.10.10.10.30.3
Progressive ratio test 1 inactive lever presses3.63.95.6-1.52.4
Progressive ratio test 2 active lever presses0.20.20.30.10.6
Progressive ratio test 2 breakpoint0.10.20.3-0.20.5
Progressive ratio test 2 inactive lever presses0.20.30.4-0.40.6
Incentive Sensitization - Responses0.10.10.10.30.2
Incentive Sensitization - Breakpoint0.10.10.10.30.2
Sum of active levers in priming session hrs 5-61.91.82.41.5-1.1
Progressive ratio1.82.02.3-1.51.3
Food seeking constrained by brief footshock0.10.10.2-0.20.4
Seeking ratio, punishment vs. effort1.01.31.81.3-0.8
Retroperitoneal fat weight0.10.40.80.9-0.1
Reaction time number correct0.10.20.3-0.60.1
Reaction time mean minus median0.81.01.91.4-0.3
Reaction time mean minus median AUC0.50.61.11.0-0.4
Reaction time num false alarms3.24.35.2-2.31.9
Reaction time num false alarms AUC4.05.66.5-2.52.2
Reaction time trials correct on left0.10.20.3-0.60.1
Reaction time trials on left0.10.10.2-0.50.1
Reaction time mean1.31.83.21.8-0.7
Reaction time mean AUC1.01.42.51.6-0.4
Median of all reaction times1.11.52.51.6-0.7
Reaction time omissions0.40.61.01.0-0.4
Reaction time false alarm rate2.23.13.3-1.81.7
Reaction time premature initiation rate0.50.71.2-0.5-1.1
Reaction time premature initiations0.50.70.7-0.8-0.9
Std. dev. reaction times1.62.23.61.9-0.9
Reaction time trials completed0.10.10.2-0.50.1
Reaction time trials AUC0.10.20.3-0.60.2
Run reversals in cocaine runway, females1.11.01.1-1.01.1
Run reversals in cocaine runway, males0.60.51.10.1-1.0
Latency to leave start box in cocaine runway5.25.67.7-2.81.9
Latency to leave start box in cocaine runway, F5.56.07.5-2.72.1
Latency to leave start box in cocaine runway, M0.80.71.3-1.10.4
Std. dev. time between licks in bursts1.72.12.7-1.61.2
Total sessions with >9 infusions1.01.11.5-0.91.2
Short access day 1 total inactive lever presses0.70.81.00.7-1.0
Short access day 10 total inactive lever presses0.00.00.00.00.1
Short access day 1 total infusions0.00.00.00.10.1
Short access day 10 total infusions1.41.61.81.4-1.1
Short access total infusions0.00.00.00.1-0.0
Short access day 1 locomotion0.50.50.7-0.60.8
Short access day 10 total locomotion0.50.50.80.5-0.9
Short access total locomotion0.10.10.10.20.2
One hour access (0.3 mA shock)0.80.91.00.9-1.0
Compulsive drug intake0.30.30.5-0.70.3
One hour access (shock baseline)2.02.33.11.8-1.2
Social response proportion5.05.46.82.6-2.0
Social responses1.52.03.41.8-0.8
Social time0.40.51.11.0-0.2
Soleus weight0.30.80.80.9-0.9
Bone: stiffness1.52.44.52.1-0.6
Tibialis anterior weight0.82.62.8-1.71.6
Time to tail flick, vehicle, before self-admin1.01.11.5-0.81.2
Time to tail flick, vehicle, after self-admin0.00.00.1-0.10.3
Time to tail flick, test, before self-admin0.20.20.4-0.60.1
Time to tail flick, test, after self-admin1.31.31.9-0.91.4
Delta time to tail flick, vehicle, before/after SA0.10.10.10.3-0.3
Delta time to tail flick, test, before/after SA0.40.30.5-0.40.7
Tibia length2.46.811.53.4-1.4
Ambulatory time before self-admin1.11.11.21.1-1.0
Ambulatory time after self-admin0.10.10.1-0.3-0.2
Bone: tissue strength0.40.40.70.40.8
Total heroin consumption0.10.10.10.3-0.2
Bone: trabecular number2.53.94.72.2-1.8
Bone: trabecular spacing0.70.81.2-1.10.7
Bone: trabecular thickness2.22.72.91.6-1.7
Bone: trabecular tissue density0.40.60.9-0.51.0
Water consumed over 24 hours0.40.40.8-0.90.1
Number of responses in last shaping day2.93.04.0-1.42.0