Hub : Genes

Ccdc144b

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Ccdc144b	0.04	0.05	5.7e-04	0.01	0.01	0.01	0.01	5.7e-03	2.2e-03	4.3e-03	3.8e-03
2	NAcc	alternative TSS	XM_039103619.2	0.04	0.03	3.0e-05	0.01	0.02	0.02	0.02	3.9e-03	2.2e-04	2.2e-04	6.4e-04
3	pVTA	alternative TSS	XM_039103619.2	0.04	0.03	2.3e-03	0.01	0.03	0.01	0.01	5.8e-02	4.2e-03	2.2e-02	4.3e-02
4	BLA	alternative polyA	XM_063282872.1	0.08	0.06	1.7e-03	0.01	0.04	0.03	0.02	8.7e-02	4.4e-03	7.4e-03	3.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.3	-0.5	0.6	-0.2	-0.5
Area under the delay curve	0.9	1.0	2.0	-1.4	1.4	0.2	-0.3
BMI with tail	4.2	14.6	16.9	-4.1	3.8	4.1	3.3
BMI without tail	2.0	6.2	8.8	-3.0	2.8	2.3	1.6
Body weight	4.0	17.7	23.3	-4.8	4.1	4.3	3.5
Weight adjusted by age	0.1	0.2	0.4	0.4	-0.6	-0.5	-0.3
Bone surface	0.5	0.8	1.2	-0.8	0.6	1.1	1.0
Bone volume	0.1	0.1	0.2	-0.5	0.3	0.3	0.2
Breakpoint value in progressive ratio session	1.2	1.4	1.8	-1.2	1.1	1.3	1.2
Number of licking bursts	2.3	3.7	5.1	-2.3	1.9	2.0	1.5
Context. condit. distance diff. score	0.9	1.1	2.8	-0.3	0.4	-1.2	-1.7
Locomotion velocity, session 1	1.2	1.3	3.2	-0.2	-0.2	1.4	1.8
Locomotion distance, session 1	2.3	2.9	5.5	-1.0	0.6	2.1	2.4
Locomotion velocity, session 2	1.7	2.0	4.5	-0.5	0.0	1.8	2.1
Locomotion distance, session 2	1.1	1.6	3.6	-0.5	-0.1	1.5	1.9
Locomotion velocity, session 3	0.0	0.0	0.0	0.2	-0.1	0.1	0.2
Locomotion distance, session 3	0.0	0.1	0.1	-0.0	-0.2	0.2	0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.0	0.6	-0.9	0.5	1.0
Stereotopy head waving duration, day 3	0.0	0.0	0.1	0.2	-0.0	0.2	0.2
Locomotion velocity, session 7	0.5	0.6	1.4	-0.1	-0.3	0.9	1.2
Locomotion distance, session 7	0.8	1.1	1.6	1.0	-1.3	-1.1	-0.8
Stereotopy head waving bouts, day 7	0.9	1.0	1.5	-0.9	0.6	1.2	1.2
Stereotopy head waving duration, day 7	0.7	0.8	1.2	-0.7	0.5	1.1	1.1
Locomotion velocity, session 8	0.9	1.1	2.1	-1.4	1.5	0.6	0.2
Locomotion distance, session 8	0.5	0.8	1.6	-1.3	1.0	0.6	0.3
Degree of sensitization distance	1.4	1.4	1.8	1.1	-1.1	-1.4	-1.2
Degree of sensitization stereotypy	0.8	0.8	0.9	-1.0	1.0	1.0	0.8
Conditioned locomotion	2.5	2.9	3.7	1.6	-1.5	-1.9	-1.7
Cocaine response after cond. corrected	1.0	1.3	2.9	0.5	-0.1	-1.4	-1.7
Cocaine response after cond. not corrected	0.7	0.8	1.0	0.9	-0.5	-1.0	-1.0
Cocaine response before conditioning	1.0	1.2	2.8	0.4	-0.5	1.2	1.7
Saline control response	1.0	1.3	2.9	-0.5	0.1	1.4	1.7
Bone: connectivity density	1.2	1.9	2.3	-1.4	1.3	1.5	1.3
Bone: cortical apparent density	0.6	0.8	1.6	0.9	-1.3	-0.7	-0.4
Bone: cortical area	0.8	1.2	1.5	-1.1	1.0	1.2	1.0
Bone: cortical porosity	0.3	0.4	0.6	0.2	0.8	-0.4	-0.8
Bone: cortical porosity	0.3	0.3	0.8	0.0	0.9	-0.3	-0.7
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.0	-0.4	-0.5
Bone: cortical thickness	0.4	0.4	0.6	-0.6	0.5	0.8	0.7
Bone: cortical tissue density	0.5	0.7	1.6	0.9	-1.3	-0.7	-0.3
Condit. Reinf. active minus inactive responses	0.9	1.0	1.4	-0.9	0.8	1.2	1.0
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.2	-0.9	1.1	0.6	0.2
Condit. Reinf. active responses	3.4	4.2	5.8	-1.8	1.6	2.4	2.2
Condit. Reinf. inactive responses	4.2	5.1	8.8	-1.6	1.1	2.8	3.0
Incentive salience index mean	0.9	1.1	1.5	-0.9	0.7	1.2	1.2
Condit. Reinf. lever presses	0.9	1.2	2.6	-0.5	0.2	1.4	1.6
Condit. Reinf. active minus inactive responses	0.7	0.9	1.6	-0.5	0.6	1.2	1.3
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.6	0.2	0.1	-0.6	-0.8
Condit. Reinf. active responses	2.5	3.5	6.6	-1.0	0.8	2.4	2.6
Condit. Reinf. inactive responses	6.4	8.3	14.5	-1.9	1.4	3.6	3.8
Condit. Reinf. lever presses	1.6	2.2	2.8	-1.7	1.6	1.5	1.0
Condit. Reinf. lever reinforcers received	2.4	3.3	5.9	-1.1	0.9	2.3	2.4
Conditioned reinforcement - actives	0.5	0.9	1.5	1.2	-1.2	0.3	0.8
Conditioned reinforcement - inactives	0.7	1.0	2.2	1.5	-1.1	-0.7	-0.5
Conditioned locomotion	0.8	1.0	2.4	-0.4	-0.1	1.2	1.6
Patch foraging indifference point 0 sec	2.2	4.1	7.0	-2.7	2.5	1.5	0.8
Patch foraging indifference point AUC	0.2	0.2	0.6	0.0	-0.3	0.5	0.8
Delay disc. indifference point, 0s delay	0.4	0.4	0.9	0.7	-1.0	-0.0	0.5
Delay disc. indifference point, 16s delay	0.7	0.8	1.7	-1.3	1.1	0.3	-0.0
Delay disc. indifference point, 2s delay	0.7	0.8	1.5	-1.2	1.2	0.3	-0.1
Delay disc. indifference point, 24s delay	0.3	0.4	0.9	-0.2	0.2	-0.7	-0.9
Delay disc. indifference point, 4s delay	1.1	1.1	1.8	-1.3	1.3	0.8	0.5
Delay disc. indifference point, 8s delay	0.4	0.5	1.0	-0.5	0.6	-0.6	-1.0
Indifference point function ln k	0.4	0.8	1.4	-0.5	1.0	-0.6	-1.2
Indifference point function log k	0.4	0.8	1.4	-0.5	1.0	-0.6	-1.2
Patch foraging total patch changes 0 sec	1.7	3.3	5.4	-2.3	2.3	1.4	0.8
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.0	-0.3	-0.4	-0.3
Patch foraging total patch changes 18 sec	0.7	1.0	1.3	-1.1	1.0	1.1	0.9
Patch foraging total patch changes 24 sec	2.3	4.0	5.8	-2.4	2.2	1.9	1.4
Patch foraging total patch changes 6 sec	0.9	1.4	2.2	-1.5	1.4	1.0	0.7
Patch foraging time to switch 0 sec	0.5	1.0	1.2	1.0	-1.0	-1.1	-0.9
Patch foraging water rate 0 sec	0.0	0.0	0.0	-0.1	0.1	-0.0	-0.1
Patch foraging water rate 12 sec	0.1	0.2	0.4	0.0	-0.1	0.5	0.7
Patch foraging water rate 18 sec	0.4	0.6	0.9	-0.5	0.4	0.9	1.0
Patch foraging water rate 24 sec	0.4	0.5	0.9	-0.7	0.2	0.9	1.0
Patch foraging water rate 6 sec	0.0	0.1	0.1	-0.0	0.1	0.3	0.3
Seeking ratio, delayed vs. immediate footshock	2.6	3.2	4.2	-2.0	2.0	1.7	1.2
Distance traveled before self-admin	1.3	1.7	3.2	-1.8	1.3	1.1	0.8
Distance traveled after self-admin	3.6	4.5	6.1	-2.5	1.9	2.2	1.9
Extensor digitorum longus weight	4.5	17.7	22.2	-4.7	4.6	4.2	3.1
Bone: elastic displacement	1.8	2.1	5.3	0.1	0.9	-1.6	-2.3
Bone: elastic work	2.6	3.3	6.4	1.2	-0.5	-2.3	-2.5
Bone: endosteal estimation	2.4	5.4	7.0	-2.4	1.8	2.6	2.4
Bone: endosteal perimeter	1.1	2.4	4.1	-1.2	0.7	1.9	2.0
Epididymis fat weight	2.2	7.5	9.9	-3.2	3.0	2.7	2.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.7	0.5	0.5	0.4
Delta time in open arm before/after self-admin	0.9	0.9	1.5	0.7	-0.3	-1.2	-1.2
Diff in mean of infusions in LGA sessions	0.6	0.7	1.4	-1.1	1.2	0.4	0.0
Delay discount exponential model param	0.9	1.0	2.1	1.3	-1.5	-0.1	0.4
Extinction: sum of active levers before priming	0.1	0.1	0.3	-0.1	-0.2	0.4	0.6
Active lever presses in extinction session 6	0.1	0.0	0.2	-0.2	0.4	0.1	-0.1
Bone: final force	1.8	2.8	3.5	-1.7	1.6	1.9	1.6
Bone: final moment	1.8	2.8	3.3	-1.8	1.7	1.8	1.4
Food consumed during 24 hour testing period	0.8	1.0	1.9	-1.4	1.1	0.9	0.6
Glucose	0.2	0.3	0.6	0.6	-0.8	-0.2	0.1
Heart weight	2.5	3.8	5.4	-2.1	2.3	1.9	1.3
Delay discount hyperbolic model param	0.9	1.0	2.2	1.3	-1.5	-0.2	0.4
Intermittent access intake day 1-15 change	1.0	2.1	3.8	1.9	-1.5	-1.2	-0.9
Intermittent access intake escalation	0.8	1.6	3.1	1.7	-1.4	-1.0	-0.7
Intermittent access intake escalation 2	0.3	0.4	0.7	0.8	-0.6	-0.5	-0.4
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.8	0.9	-0.6	-0.5	-0.4
Intermitt. access day 15 inactive lever presses	0.6	1.2	3.0	1.7	-1.0	-0.7	-0.4
Intermitt. access escalation Index	0.2	0.3	0.4	0.7	-0.3	-0.6	-0.6
Intermittent access day 1 total infusions	1.6	2.5	5.6	2.0	-2.4	-0.3	0.7
Intermittent access day 15 total infusions	2.2	3.3	6.3	2.5	-2.5	-0.6	0.3
Intermittent access terminal intake (last 3 days)	2.9	3.9	7.6	2.7	-2.7	-0.8	0.2
Intermittent access total infusions	1.9	2.2	4.1	1.6	-2.0	0.4	1.4
Intermittent access day 1 locomotion	0.8	1.0	2.3	0.3	-0.9	0.9	1.5
Intermittent access day 15 total locomotion	0.6	1.2	2.2	-0.8	0.3	1.3	1.5
Intermittent access total locomotion	1.2	1.5	3.3	-0.7	-0.1	1.4	1.8
Intermittent access standard deviation	0.2	0.5	1.0	1.0	-0.5	-0.6	-0.5
Left kidney weight	0.4	1.7	3.4	-1.9	1.7	0.6	0.0
Right kidney weight	1.1	5.1	9.6	-2.8	3.1	1.6	0.6
Cocaine induced anxiety	1.8	2.5	4.3	-2.1	1.8	1.3	0.8
Post-drug Anxiety	1.0	1.1	1.9	-1.1	1.4	0.9	0.5
Baseline Anxiety	1.5	1.7	2.9	1.7	-1.2	-1.2	-1.0
Tail length	0.1	0.2	0.5	-0.7	0.5	0.1	-0.2
Length with tail	0.6	2.8	4.4	-2.1	1.7	1.6	1.2
Length without tail	2.5	8.0	10.7	-3.3	2.8	2.9	2.3
Times rat made contact with spout	0.2	0.2	0.3	-0.5	0.2	0.4	0.4
Lifetime Intake	1.9	2.3	4.3	1.8	-2.1	0.3	1.3
Liver weight, left	0.1	0.2	0.4	0.3	-0.6	0.2	0.5
Liver weight, right	0.2	0.4	0.7	0.8	-0.6	-0.6	-0.5
Locomotor activity	0.2	0.4	1.1	1.0	-0.6	-0.3	-0.2
Locomotor testing distance	1.5	2.7	4.5	-0.9	1.2	2.1	2.0
Locomotor testing rearing	0.0	0.1	0.3	0.6	-0.2	-0.0	0.0
Locomotion in novel chamber	1.6	2.1	2.8	-1.7	1.3	1.5	1.2
Locomotion in novel chamber post-restriction	0.0	0.0	0.0	0.1	0.1	0.1	0.1
Fecal boli incidents, locomotor time 1	1.3	1.9	2.3	1.5	-1.3	-1.4	-1.2
Change in fecal boli incidents, locomotor task	1.6	1.6	2.0	-1.3	0.9	1.4	1.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	0.3	-0.6	0.0	0.3
Bouts of movement, locomotor time 1	0.8	0.9	1.1	1.1	-0.8	-1.0	-0.9
Total resting periods, locomotor time 1	1.9	2.2	2.7	1.5	-1.1	-1.7	-1.6
Rest time, locomotor task time 1	1.1	1.4	1.7	1.3	-1.0	-1.3	-1.1
Distance moved, locomotor task time 1	1.9	2.8	3.3	-1.8	1.4	1.8	1.6
Vertical activity count, locomotor time 1	1.4	3.3	4.6	-2.1	1.8	1.8	1.4
Time >=10cm from walls, locomotor time 2	0.3	0.4	0.7	0.8	-0.8	-0.5	-0.2
Bouts of movement, locomotor time 2	2.0	3.2	4.6	2.1	-1.4	-1.8	-1.7
Total resting periods, locomotor time 2	1.4	2.5	3.4	1.9	-1.2	-1.6	-1.6
Rest time, locomotor task time 2	0.2	0.2	0.4	0.3	-0.1	-0.5	-0.6
Distance moved, locomotor task time 2	1.3	1.5	2.1	-1.2	0.7	1.4	1.5
Vertical activity count, locomotor time 2	1.1	1.5	2.9	-1.0	0.3	1.4	1.7
Light reinforcement 1	0.5	1.2	1.9	1.4	-1.2	-1.0	-0.6
Light reinforcement 2	0.3	0.5	0.8	0.8	-0.9	-0.7	-0.4
Bone: marrow area	2.6	5.7	7.2	-2.5	1.9	2.7	2.4
Bone: maximum diameter	1.1	2.0	2.9	-1.3	1.0	1.7	1.6
Bone: maximum force	0.5	1.0	1.2	-1.0	0.8	1.1	1.0
Bone: maximum moment	0.5	0.9	1.3	-1.1	1.0	1.0	0.7
Mean time between licks in bursts	0.0	0.1	0.1	0.1	-0.3	-0.4	-0.4
Mean num. licks in bursts	1.3	2.0	2.7	1.6	-1.4	-1.5	-1.2
Cd content in liver	1.0	1.1	2.0	1.4	-1.4	-0.6	-0.2
Co content in liver	1.0	1.1	1.6	-1.2	1.2	1.0	0.7
Cu content in liver	0.2	0.3	0.3	-0.6	0.3	0.6	0.6
Fe content in liver	0.5	0.6	0.7	0.7	-0.6	-0.8	-0.8
K content in liver	0.9	0.8	1.4	0.5	-0.7	-1.2	-1.1
Mg content in liver	0.6	0.6	1.3	0.1	-0.1	-1.0	-1.2
Mn content in liver	2.0	2.2	2.9	1.5	-1.2	-1.7	-1.5
Na content in liver	0.7	0.8	1.4	-0.7	0.2	1.0	1.2
Rb content in liver	0.3	0.4	0.9	-0.6	1.0	-0.1	-0.5
Se content in liver	2.3	2.7	4.1	2.0	-2.0	-1.4	-0.8
Sr content in liver	0.3	0.3	0.4	0.6	-0.6	0.2	0.5
Zn content in liver	0.1	0.1	0.4	-0.6	0.3	0.3	0.2
Bone: minimum diameter	2.0	3.6	4.3	-2.0	1.8	2.1	1.7
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.1	-0.4	0.2	0.4
Time in novel zone, hab. session 1	0.0	0.0	0.1	0.3	-0.1	-0.0	0.0
Total zone transitions, hab. session 1	1.3	1.9	2.7	-1.4	1.6	1.4	1.0
Total locomotion distance, hab. session 1	0.9	1.3	1.9	-0.8	1.0	1.4	1.3
Locomotion velocity, hab. session 1	1.0	1.4	1.7	-1.0	1.2	1.3	1.1
Time in familiar zone, hab. session 2	3.7	3.9	5.7	2.4	-2.0	-1.9	-1.5
Time in novel zone, hab. session 2	3.3	3.3	4.8	-2.2	2.0	1.7	1.2
Total zone transitions, hab. session 2	2.9	3.7	5.3	-1.7	1.4	2.3	2.2
Total locomotion distance, hab. session 2	1.6	2.1	3.2	-1.1	1.0	1.8	1.8
Locomotion velocity, hab. session 2	2.0	2.7	4.5	-1.1	0.9	2.1	2.1
Novel to familiar place preference ratio	0.9	1.0	1.8	-0.6	1.1	-0.7	-1.3
Novelty place preference	1.1	1.2	2.3	-0.5	1.2	-0.8	-1.5
Time in novel zone, NPP test	1.2	1.3	2.3	-0.9	1.5	-0.6	-1.4
Total zone transitions, NPP test	1.0	1.5	3.7	-0.1	-0.3	1.5	1.9
Total locomotion distance, NPP test	0.8	1.1	2.6	0.2	-0.4	1.2	1.6
Locomotion velocity, NPP test	0.7	1.0	2.1	0.6	-0.8	0.9	1.4
Intraocular pressure	0.7	1.1	1.8	1.3	-1.0	-1.0	-0.7
Delta distance traveled before/after self-admin	0.3	0.3	0.5	-0.5	0.4	0.7	0.6
Delta ambulatory time before/after self-admin	0.3	0.4	0.5	-0.6	0.5	0.7	0.6
Parametrial fat weight	0.6	1.4	2.1	-0.9	0.7	1.4	1.4
Pavlov. Cond. lever latency	0.8	1.0	2.2	0.4	0.0	-1.3	-1.5
Pavlov. Cond. magazine entry latency	2.4	3.1	4.0	-1.8	1.3	2.0	1.8
Pavlov. Cond. change in total contacts	0.6	0.6	1.2	-0.5	0.1	1.0	1.1
Pavlov. Cond. index score	2.5	3.1	5.1	-1.4	0.8	2.2	2.3
Pavlov. Cond. latency score	2.0	2.5	4.6	-1.1	0.5	2.0	2.2
Pavlov. Cond. lever contacts	1.2	1.4	2.9	-0.7	0.2	1.5	1.7
Pavlov. Cond. magazine entry number	3.6	4.5	5.7	2.4	-1.7	-2.3	-2.1
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.2	1.1	-0.9	-1.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	2.2	2.8	4.4	-1.4	0.7	2.0	2.1
Pavlov. Cond. response bias	2.9	3.5	4.6	-2.0	1.3	2.1	2.0
Pavlov. Cond. lever latency	3.7	5.0	5.9	2.4	-2.2	-2.4	-1.9
Pavlov. Cond. magazine entry latency	1.7	2.1	3.9	-2.0	2.0	0.8	0.0
Pavlov. Cond. change in total contacts	3.4	5.5	6.7	-2.4	2.2	2.6	2.2
Pavlov. Cond. index score	5.3	7.1	9.6	-3.1	2.8	2.6	2.0
Pavlov. Cond. latency score	4.6	6.1	8.5	-2.9	2.6	2.4	1.8
Pavlov. Cond. lever contacts	4.0	5.5	6.4	-2.5	2.2	2.5	2.1
Pavlov. Cond. magazine entry number	4.6	5.7	9.4	3.1	-2.9	-1.9	-1.1
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	0.3	-0.3	0.4	0.6
Pavlov. Cond. lever-magazine prob. diff.	4.9	6.6	8.8	-3.0	2.7	2.6	1.9
Pavlov. Cond. response bias	3.9	5.3	6.9	-2.6	2.5	2.3	1.7
Time in closed arm before self-admin	0.5	0.7	1.0	1.0	-0.5	-0.9	-0.8
Time in closed arm after self-admin	0.3	0.4	0.4	0.6	-0.6	-0.7	-0.5
Time in open arm before self-admin	4.0	4.3	6.9	-2.6	2.1	2.0	1.5
Time in open arm after self-admin	0.3	0.3	0.7	-0.7	0.9	0.2	-0.1
Bone: periosteal estimation	2.1	4.4	5.6	-2.1	1.7	2.4	2.1
Bone: periosteal perimeter	0.5	0.8	1.6	-0.5	0.3	1.2	1.2
Bone: post-yield work	0.3	0.4	0.6	-0.6	-0.0	0.7	0.8
Progressive ratio test 1 active lever presses	1.6	2.0	4.7	0.4	-0.9	1.4	2.2
Progressive ratio test 1 breakpoint	1.8	2.2	5.3	0.4	-0.9	1.6	2.3
Progressive ratio test 1 inactive lever presses	1.0	1.5	2.7	1.6	-1.7	0.1	0.8
Progressive ratio test 2 active lever presses	2.0	2.3	3.8	1.3	-2.0	0.8	1.8
Progressive ratio test 2 breakpoint	2.0	2.2	3.6	1.2	-1.9	0.8	1.8
Progressive ratio test 2 inactive lever presses	0.9	1.5	3.1	1.8	-1.6	-0.1	0.5
Incentive Sensitization - Responses	0.6	0.8	1.8	0.8	-1.3	0.2	0.8
Incentive Sensitization - Breakpoint	0.7	0.9	1.9	0.9	-1.4	0.2	0.8
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.5	-0.7	0.2	0.5
Progressive ratio	0.1	0.1	0.2	0.3	-0.2	0.3	0.4
Food seeking constrained by brief footshock	1.9	2.3	3.9	-1.6	2.0	1.4	0.8
Seeking ratio, punishment vs. effort	0.5	0.7	1.6	-1.1	1.2	0.3	-0.1
Retroperitoneal fat weight	2.6	11.0	13.9	-3.3	2.9	3.7	3.3
Reaction time number correct	0.8	1.6	3.2	1.4	-1.8	0.2	1.1
Reaction time mean minus median	1.4	3.5	7.2	-2.5	2.7	0.7	-0.3
Reaction time mean minus median AUC	0.9	2.2	4.5	-2.0	2.1	0.7	-0.1
Reaction time num false alarms	0.1	0.1	0.1	0.3	-0.0	-0.3	-0.3
Reaction time num false alarms AUC	0.1	0.1	0.3	0.5	-0.4	-0.3	-0.1
Reaction time trials correct on left	0.8	1.6	3.2	1.4	-1.8	0.2	1.1
Reaction time trials on left	0.8	1.5	3.0	1.4	-1.7	0.2	1.0
Reaction time mean	1.2	1.8	4.2	-1.6	2.1	0.0	-0.8
Reaction time mean AUC	1.2	1.9	4.1	-1.5	2.0	-0.2	-1.0
Median of all reaction times	0.7	1.0	1.9	-0.8	1.4	-0.5	-1.1
Reaction time omissions	1.3	1.9	3.3	-1.1	1.8	-0.7	-1.6
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	0.5	-0.2	-0.4
Reaction time premature initiation rate	4.6	6.3	8.2	2.5	-2.0	-2.9	-2.6
Reaction time premature initiations	3.3	5.9	8.1	2.8	-2.7	-2.3	-1.7
Std. dev. reaction times	2.3	4.3	8.8	-2.7	3.0	0.9	-0.2
Reaction time trials completed	0.8	1.5	3.0	1.4	-1.7	0.2	1.0
Reaction time trials AUC	0.8	1.4	2.8	1.3	-1.7	0.2	1.0
Run reversals in cocaine runway, females	0.4	0.4	0.9	-0.1	0.2	0.9	0.9
Run reversals in cocaine runway, males	0.9	0.9	1.3	-0.8	0.6	1.2	1.1
Latency to leave start box in cocaine runway	0.3	0.3	0.7	-0.3	0.8	-0.2	-0.8
Latency to leave start box in cocaine runway, F	0.3	0.4	1.0	0.1	0.4	-0.6	-1.0
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	-0.7	1.1	0.2	-0.3
Std. dev. time between licks in bursts	0.4	0.6	1.0	-1.0	1.0	0.6	0.2
Total sessions with >9 infusions	1.2	1.5	2.9	1.5	-1.7	0.1	0.9
Short access day 1 total inactive lever presses	0.4	0.5	0.9	1.0	-0.9	0.2	0.6
Short access day 10 total inactive lever presses	0.2	0.5	0.9	-1.0	0.9	0.2	-0.2
Short access day 1 total infusions	1.0	1.3	2.4	1.4	-1.5	0.2	0.9
Short access day 10 total infusions	1.2	1.6	2.4	1.4	-1.6	0.5	1.3
Short access total infusions	1.8	2.3	4.6	1.8	-2.1	0.2	1.2
Short access day 1 locomotion	1.0	1.3	1.9	-1.0	0.9	1.4	1.3
Short access day 10 total locomotion	0.3	0.6	0.9	-1.0	0.6	0.8	0.8
Short access total locomotion	0.9	1.0	2.5	-0.4	-0.2	1.2	1.6
One hour access (0.3 mA shock)	0.9	1.0	2.5	0.1	-0.9	0.9	1.6
Compulsive drug intake	3.6	4.3	7.1	-2.7	2.0	2.0	1.6
One hour access (shock baseline)	1.7	2.6	5.3	2.2	-2.3	-0.5	0.4
Social response proportion	3.8	4.3	5.5	2.1	-1.9	-2.4	-2.0
Social responses	0.0	0.1	0.2	0.1	-0.4	-0.2	-0.1
Social time	6.5	8.8	11.4	3.0	-2.5	-3.4	-3.0
Soleus weight	1.3	3.8	8.1	-2.5	2.8	0.3	-0.8
Bone: stiffness	0.6	1.0	1.7	-0.8	0.5	1.2	1.3
Tibialis anterior weight	7.5	25.5	29.0	-5.4	4.9	5.4	4.5
Time to tail flick, vehicle, before self-admin	1.1	1.2	1.8	1.0	-0.4	-1.2	-1.3
Time to tail flick, vehicle, after self-admin	2.1	2.8	4.8	2.0	-2.2	-1.4	-0.8
Time to tail flick, test, before self-admin	1.8	1.9	3.9	-1.8	2.0	0.1	-0.7
Time to tail flick, test, after self-admin	0.6	0.6	1.1	-1.0	1.0	-0.1	-0.5
Delta time to tail flick, vehicle, before/after SA	2.2	2.1	4.5	1.7	-2.1	-1.0	-0.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.2	-0.5	-0.0	0.2
Tibia length	1.0	2.7	6.9	1.8	-2.6	-0.4	0.6
Ambulatory time before self-admin	0.6	0.9	1.5	-1.2	0.7	0.9	0.8
Ambulatory time after self-admin	1.5	1.7	2.2	-1.5	0.9	1.4	1.4
Bone: tissue strength	1.5	1.5	3.0	0.8	-0.2	-1.5	-1.7
Total heroin consumption	0.5	0.6	0.9	-0.9	0.9	0.7	0.5
Bone: trabecular number	0.1	0.1	0.4	-0.3	0.6	0.1	-0.2
Bone: trabecular spacing	0.4	0.5	1.3	0.7	-1.2	-0.3	0.1
Bone: trabecular thickness	0.2	0.2	0.5	-0.3	-0.0	-0.6	-0.7
Bone: trabecular tissue density	2.0	3.0	4.3	1.5	-1.4	-2.1	-1.9
Water consumed over 24 hours	1.4	1.9	2.9	-1.7	1.4	1.3	0.9
Number of responses in last shaping day	0.5	0.6	1.1	-0.3	0.4	1.0	1.0