Hub : Genes

Ccdc117

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	NM_001017502.1	0.02	0.02	4.4e-03	0.02	0.01	0.01	0.01	4.8e-03	1.1e-02	4.4e-02	9.6e-03
2	Adipose	isoform ratio	XM_039092297.1	0.02	0.02	5.0e-03	0.02	0.01	0.01	0.01	5.3e-03	1.3e-02	4.4e-02	1.2e-02
3	NAcc	isoform ratio	XM_039092297.1	0.02	0.01	6.0e-03	0.01	0.02	0	0.01	5.7e-03	4.9e-03	7.7e-02	9.6e-03
4	NAcc	isoform ratio	NM_001017502.1	0.02	0.01	6.8e-03	0.01	0.02	0	0.01	1.0e-02	5.1e-03	7.0e-02	2.2e-02
5	Liver	isoform ratio	NM_001017502.1	0.03	0.03	5.4e-03	0.01	0.01	-0	0.01	3.6e-02	1.1e-02	5.0e-01	1.7e-02
6	Liver	isoform ratio	XM_039092297.1	0.03	0.03	7.0e-03	0.01	0.01	-0	0.01	3.5e-02	1.2e-02	3.8e-01	1.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	0.0	-0.0
Area under the delay curve	3.6	3.8	4.4	-1.9	1.9	-2.1	2.1	1.9	-1.9
BMI with tail	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0	0.1	-0.1
BMI without tail	0.1	0.1	0.2	0.5	-0.5	0.2	-0.2	0.3	-0.2
Body weight	1.3	5.6	6.2	-2.2	2.2	-2.4	2.4	2.5	-2.5
Weight adjusted by age	0.6	0.6	0.9	-0.7	0.7	-0.7	0.8	0.9	-0.9
Bone surface	0.3	0.5	0.6	-0.7	0.7	-0.6	0.6	0.8	-0.8
Bone volume	0.3	0.5	0.7	-0.6	0.6	-0.5	0.6	0.8	-0.9
Breakpoint value in progressive ratio session	1.3	1.5	1.7	-1.1	1.1	-1.3	1.3	1.2	-1.2
Number of licking bursts	3.3	3.9	4.0	-2.0	2.0	-1.9	1.9	2.0	-2.0
Context. condit. distance diff. score	3.9	4.7	5.1	2.2	-2.2	2.3	-2.3	-2.0	2.0
Locomotion velocity, session 1	0.2	0.2	0.4	-0.4	0.4	-0.1	0.0	-0.6	0.6
Locomotion distance, session 1	0.4	0.5	0.7	0.8	-0.8	0.8	-0.8	-0.6	0.6
Locomotion velocity, session 2	0.1	0.1	0.1	-0.3	0.3	-0.1	0.0	-0.4	0.3
Locomotion distance, session 2	1.1	1.6	1.8	1.2	-1.2	1.3	-1.3	-1.3	1.3
Locomotion velocity, session 3	2.2	2.6	3.0	1.7	-1.7	1.7	-1.7	-1.3	1.3
Locomotion distance, session 3	0.2	0.3	0.6	-0.3	0.3	-0.4	0.4	0.7	-0.8
Stereotopy head waving bouts, day 3	0.7	0.8	1.0	1.0	-1.0	1.0	-1.0	-0.8	0.7
Stereotopy head waving duration, day 3	2.1	2.5	2.6	1.6	-1.6	1.6	-1.6	-1.6	1.6
Locomotion velocity, session 7	0.2	0.3	0.3	-0.6	0.6	-0.4	0.4	0.5	-0.5
Locomotion distance, session 7	0.2	0.2	0.3	0.2	-0.2	0.5	-0.5	-0.5	0.5
Stereotopy head waving bouts, day 7	0.6	0.7	0.7	0.8	-0.8	0.8	-0.8	-0.8	0.9
Stereotopy head waving duration, day 7	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.0	0.0
Locomotion velocity, session 8	1.3	1.5	2.0	1.0	-1.0	1.3	-1.3	-1.4	1.4
Locomotion distance, session 8	7.7	11.3	12.0	3.3	-3.3	3.5	-3.5	-3.3	3.3
Degree of sensitization distance	2.5	2.5	3.7	1.2	-1.2	1.5	-1.6	-1.9	1.9
Degree of sensitization stereotypy	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2	0.1	-0.1
Conditioned locomotion	0.9	1.1	1.6	1.3	-1.3	1.1	-1.1	-0.7	0.7
Cocaine response after cond. corrected	1.6	1.8	2.0	-1.4	1.4	-1.4	1.4	1.3	-1.2
Cocaine response after cond. not corrected	1.8	2.0	2.0	-1.4	1.4	-1.4	1.4	1.4	-1.4
Cocaine response before conditioning	0.3	0.4	0.6	0.7	-0.7	0.6	-0.6	-0.5	0.5
Saline control response	0.6	0.8	0.8	0.9	-0.9	0.9	-0.9	-0.8	0.8
Bone: connectivity density	0.2	0.2	0.3	0.6	-0.6	0.6	-0.6	-0.3	0.3
Bone: cortical apparent density	0.8	1.1	1.2	-1.1	1.1	-1.0	1.0	1.0	-1.0
Bone: cortical area	3.3	4.9	5.0	-2.2	2.2	-2.2	2.2	2.2	-2.2
Bone: cortical porosity	0.0	0.0	0.1	-0.0	0.0	-0.2	0.2	0.3	-0.3
Bone: cortical porosity	0.1	0.2	0.2	0.5	-0.5	0.4	-0.4	-0.3	0.3
Bone: cortical thickness	2.2	3.6	4.4	-1.8	1.8	-1.8	1.8	2.1	-2.1
Bone: cortical thickness	0.3	0.4	0.6	0.7	-0.7	0.8	-0.7	-0.4	0.3
Bone: cortical tissue density	0.9	1.1	1.3	-1.1	1.1	-1.0	1.0	1.0	-1.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	-1.1	1.1	-1.1	1.0	0.8	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.3	-0.1	0.1	-0.5	0.5
Condit. Reinf. active responses	0.5	0.6	0.7	-0.9	0.9	-0.8	0.7	0.7	-0.7
Condit. Reinf. inactive responses	0.4	0.4	0.8	-0.5	0.5	-0.5	0.5	0.9	-0.9
Incentive salience index mean	1.4	1.7	1.8	-1.3	1.3	-1.3	1.3	1.2	-1.2
Condit. Reinf. lever presses	0.4	0.6	0.8	-0.6	0.6	-0.7	0.7	0.9	-0.9
Condit. Reinf. active minus inactive responses	0.5	0.6	0.7	0.7	-0.7	0.7	-0.7	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	0.0	0.0	-0.0	-0.2	0.2
Condit. Reinf. active responses	0.7	0.9	1.2	0.9	-0.9	0.9	-0.9	-1.1	1.1
Condit. Reinf. inactive responses	0.9	1.2	1.5	1.0	-1.0	1.0	-1.1	-1.2	1.2
Condit. Reinf. lever presses	0.5	0.6	0.7	0.8	-0.8	0.8	-0.8	-0.7	0.7
Condit. Reinf. lever reinforcers received	0.5	0.7	0.9	0.8	-0.8	0.8	-0.8	-1.0	0.9
Conditioned reinforcement - actives	0.0	0.0	0.0	0.0	-0.0	-0.0	0.0	-0.1	0.1
Conditioned reinforcement - inactives	0.0	0.0	0.1	-0.3	0.3	-0.3	0.2	0.1	-0.1
Conditioned locomotion	0.0	0.0	0.1	0.1	-0.1	-0.2	0.2	0.3	-0.3
Patch foraging indifference point 0 sec	1.9	3.0	3.7	-1.6	1.6	-1.7	1.7	1.9	-1.9
Patch foraging indifference point AUC	0.1	0.1	0.1	-0.4	0.4	-0.4	0.3	0.3	-0.3
Delay disc. indifference point, 0s delay	0.9	1.0	1.1	-1.0	1.0	-1.0	1.0	1.0	-1.0
Delay disc. indifference point, 16s delay	2.7	2.7	3.4	-1.7	1.7	-1.9	1.8	1.4	-1.4
Delay disc. indifference point, 2s delay	1.3	1.4	2.1	-0.9	0.9	-1.1	1.2	1.4	-1.4
Delay disc. indifference point, 24s delay	1.6	1.6	1.8	-1.3	1.3	-1.3	1.3	1.1	-1.1
Delay disc. indifference point, 4s delay	3.3	3.5	3.9	-1.7	1.7	-1.9	1.9	2.0	-2.0
Delay disc. indifference point, 8s delay	1.2	1.2	1.5	-1.1	1.1	-1.2	1.2	0.9	-0.9
Indifference point function ln k	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	0.2	-0.2
Indifference point function log k	0.0	0.0	0.1	0.1	-0.1	0.1	-0.0	0.2	-0.2
Patch foraging total patch changes 0 sec	1.9	3.1	3.8	-1.6	1.6	-1.7	1.7	1.9	-1.9
Patch foraging total patch changes 12 sec	1.1	1.5	1.6	-1.2	1.2	-1.2	1.2	1.3	-1.3
Patch foraging total patch changes 18 sec	1.7	2.1	2.5	-1.6	1.6	-1.6	1.5	1.3	-1.2
Patch foraging total patch changes 24 sec	0.9	1.1	1.2	1.1	-1.1	1.0	-1.1	-1.1	1.1
Patch foraging total patch changes 6 sec	2.1	3.2	3.5	-1.8	1.8	-1.7	1.7	1.9	-1.9
Patch foraging time to switch 0 sec	0.5	0.7	0.8	0.9	-0.9	0.8	-0.8	-0.9	0.9
Patch foraging water rate 0 sec	1.8	2.9	3.1	-1.7	1.7	-1.7	1.7	1.8	-1.8
Patch foraging water rate 12 sec	0.1	0.1	0.2	-0.3	0.3	-0.3	0.3	0.5	-0.5
Patch foraging water rate 18 sec	0.1	0.1	0.2	0.5	-0.5	0.2	-0.1	0.2	-0.2
Patch foraging water rate 24 sec	0.0	0.1	0.1	-0.4	0.4	-0.3	0.2	-0.0	0.0
Patch foraging water rate 6 sec	0.4	0.5	0.6	-0.7	0.7	-0.7	0.7	0.8	-0.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	0.7	-0.7	0.4	-0.4	-0.7	0.7
Distance traveled before self-admin	0.3	0.3	0.5	-0.3	0.3	-0.4	0.4	0.7	-0.7
Distance traveled after self-admin	0.3	0.3	0.6	-0.3	0.3	-0.4	0.5	0.8	-0.8
Extensor digitorum longus weight	3.6	14.0	14.9	-3.7	3.7	-3.7	3.7	3.9	-3.9
Bone: elastic displacement	0.6	0.7	1.0	1.0	-1.0	0.9	-0.9	-0.6	0.6
Bone: elastic work	0.1	0.1	0.3	0.0	-0.0	-0.1	0.1	0.5	-0.5
Bone: endosteal estimation	0.1	0.1	0.1	-0.4	0.4	-0.4	0.4	0.3	-0.3
Bone: endosteal perimeter	0.6	1.2	1.5	-1.2	1.2	-1.2	1.2	0.9	-0.9
Epididymis fat weight	0.3	0.8	1.1	1.0	-1.0	1.0	-1.0	-0.5	0.5
Delta time in closed arm before/after self-admin	6.8	6.6	6.7	2.6	-2.6	2.6	-2.6	-2.6	2.6
Delta time in open arm before/after self-admin	7.9	7.7	8.6	-2.7	2.7	-2.9	2.9	2.7	-2.7
Diff in mean of infusions in LGA sessions	0.3	0.3	0.6	0.7	-0.7	0.5	-0.5	-0.4	0.4
Delay discount exponential model param	3.3	3.5	4.0	1.8	-1.8	2.0	-2.0	-1.8	1.8
Extinction: sum of active levers before priming	0.4	0.4	0.6	-0.6	0.6	-0.8	0.8	0.6	-0.6
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.1	0.1	-0.3	0.4	0.4	-0.4
Bone: final force	0.4	0.6	0.8	-0.7	0.7	-0.8	0.8	0.9	-0.9
Bone: final moment	0.6	0.9	1.2	-0.8	0.8	-0.9	0.9	1.1	-1.1
Food consumed during 24 hour testing period	2.2	2.7	3.8	-1.9	1.9	-1.6	1.6	1.3	-1.3
Glucose	16.5	24.9	34.6	-5.9	5.9	-5.2	5.1	3.7	-3.7
Heart weight	0.3	0.4	0.7	0.4	-0.4	0.7	-0.8	-0.8	0.8
Delay discount hyperbolic model param	3.4	3.6	4.1	1.8	-1.8	2.0	-2.0	-1.9	1.9
Intermittent access intake day 1-15 change	0.2	0.2	0.3	-0.6	0.6	-0.5	0.5	0.3	-0.3
Intermittent access intake escalation	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	0.2	-0.2
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.6	0.7	1.0	0.6	-0.6	0.8	-0.8	-1.0	1.0
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.7	-1.3	1.3	-1.1	1.1	0.7	-0.7
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	0.3	-0.3	0.3	0.3	-0.3
Intermittent access day 1 total infusions	0.1	0.2	0.2	0.5	-0.5	0.3	-0.3	-0.4	0.4
Intermittent access day 15 total infusions	0.1	0.1	0.2	-0.3	0.3	-0.4	0.4	0.3	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.2	0.2	-0.3	0.3	0.2	-0.2
Intermittent access total infusions	0.0	0.0	0.0	-0.0	0.0	-0.2	0.2	0.2	-0.2
Intermittent access day 1 locomotion	0.9	1.0	1.1	1.1	-1.1	0.9	-0.9	-1.0	1.0
Intermittent access day 15 total locomotion	0.1	0.2	0.3	-0.3	0.3	-0.6	0.6	0.3	-0.3
Intermittent access total locomotion	0.2	0.2	0.3	-0.3	0.3	-0.6	0.6	0.4	-0.4
Intermittent access standard deviation	1.3	1.4	1.7	1.1	-1.1	1.3	-1.3	-1.1	1.1
Left kidney weight	0.0	0.0	0.1	0.2	-0.2	0.3	-0.2	-0.1	0.1
Right kidney weight	0.8	2.2	2.8	1.7	-1.7	1.6	-1.5	-1.2	1.2
Cocaine induced anxiety	3.2	3.7	3.8	-1.9	1.9	-1.9	1.9	1.9	-2.0
Post-drug Anxiety	1.1	1.2	1.5	-1.2	1.2	-1.1	1.1	0.9	-0.9
Baseline Anxiety	0.3	0.3	0.7	0.3	-0.3	0.5	-0.5	-0.8	0.8
Tail length	1.5	4.5	6.3	-1.8	1.8	-2.0	2.0	2.5	-2.5
Length with tail	2.2	7.9	8.2	-2.7	2.7	-2.8	2.9	2.9	-2.8
Length without tail	1.2	2.7	3.3	-1.8	1.8	-1.8	1.8	1.3	-1.3
Times rat made contact with spout	0.1	0.2	0.4	-0.6	0.6	-0.1	-0.0	-0.4	0.4
Lifetime Intake	0.0	0.0	0.1	-0.1	0.1	-0.2	0.2	0.3	-0.3
Liver weight, left	2.0	3.2	4.1	2.0	-2.0	1.8	-1.8	-1.5	1.5
Liver weight, right	3.7	6.1	7.4	2.7	-2.7	2.4	-2.4	-2.3	2.3
Locomotor activity	0.5	0.8	1.3	-1.1	1.1	-1.0	0.9	0.5	-0.5
Locomotor testing distance	0.2	0.3	0.5	-0.5	0.5	-0.4	0.5	0.7	-0.7
Locomotor testing rearing	2.0	3.2	3.9	-2.0	2.0	-1.7	1.7	1.7	-1.7
Locomotion in novel chamber	4.8	5.9	6.5	2.4	-2.4	2.5	-2.5	-2.3	2.3
Locomotion in novel chamber post-restriction	3.4	4.1	5.5	1.8	-1.8	1.9	-1.9	-2.3	2.3
Fecal boli incidents, locomotor time 1	0.2	0.2	0.3	0.3	-0.3	0.5	-0.5	-0.5	0.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.1	-0.4	0.4	-0.2	0.1	-0.1	0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.3	-0.1	0.1	0.3	-0.3	-0.5	0.5
Bouts of movement, locomotor time 1	0.4	0.4	0.7	-0.8	0.8	-0.7	0.7	0.3	-0.3
Total resting periods, locomotor time 1	0.1	0.2	0.3	-0.5	0.5	-0.4	0.4	-0.1	0.1
Rest time, locomotor task time 1	0.1	0.1	0.1	-0.4	0.4	-0.1	0.1	-0.2	0.2
Distance moved, locomotor task time 1	0.3	0.3	0.6	-0.3	0.3	-0.5	0.5	0.8	-0.8
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.1	0.1	-0.3	0.3	0.4	-0.4
Time >=10cm from walls, locomotor time 2	0.4	0.4	1.0	0.4	-0.4	0.5	-0.5	-1.0	1.0
Bouts of movement, locomotor time 2	0.1	0.1	0.1	0.2	-0.2	-0.2	0.2	0.3	-0.3
Total resting periods, locomotor time 2	0.1	0.1	0.1	0.1	-0.1	-0.3	0.3	0.3	-0.4
Rest time, locomotor task time 2	0.0	0.0	0.1	0.0	-0.0	0.2	-0.2	-0.2	0.2
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.2	-0.2	0.2	-0.2	-0.4	0.4
Vertical activity count, locomotor time 2	0.1	0.1	0.2	0.3	-0.3	0.2	-0.2	-0.4	0.4
Light reinforcement 1	0.1	0.2	0.5	-0.3	0.3	-0.3	0.4	0.7	-0.7
Light reinforcement 2	0.1	0.1	0.1	-0.1	0.1	-0.3	0.3	0.3	-0.3
Bone: marrow area	0.0	0.1	0.1	-0.3	0.3	-0.3	0.3	0.2	-0.2
Bone: maximum diameter	5.0	9.2	10.5	-3.2	3.2	-3.1	3.1	2.7	-2.7
Bone: maximum force	0.3	0.6	0.8	-0.7	0.7	-0.7	0.7	0.9	-0.9
Bone: maximum moment	0.5	0.9	1.2	-0.9	0.9	-0.9	0.9	1.1	-1.1
Mean time between licks in bursts	0.5	0.6	1.3	-1.1	1.1	-0.8	0.8	0.2	-0.2
Mean num. licks in bursts	2.3	2.8	3.8	1.4	-1.4	1.6	-1.7	-2.0	2.0
Cd content in liver	0.2	0.2	0.3	0.5	-0.5	0.5	-0.5	-0.4	0.4
Co content in liver	0.0	0.1	0.2	-0.0	0.0	-0.0	0.1	0.4	-0.4
Cu content in liver	0.5	0.7	1.0	-1.0	1.0	-0.7	0.7	0.7	-0.7
Fe content in liver	0.4	0.5	1.1	0.4	-0.4	0.4	-0.5	-1.0	1.0
K content in liver	0.7	0.7	1.2	-0.6	0.6	-0.7	0.8	1.1	-1.1
Mg content in liver	0.5	0.5	0.7	-0.7	0.7	-0.6	0.6	0.8	-0.9
Mn content in liver	0.2	0.3	0.7	-0.0	0.0	-0.2	0.3	0.8	-0.9
Na content in liver	4.0	4.3	4.9	-2.2	2.2	-2.2	2.1	1.8	-1.8
Rb content in liver	3.3	4.1	4.5	-2.0	2.0	-1.9	1.9	2.1	-2.1
Se content in liver	1.7	2.1	2.8	-1.2	1.2	-1.4	1.5	1.7	-1.7
Sr content in liver	1.8	1.7	2.2	-1.5	1.5	-1.4	1.4	1.0	-1.0
Zn content in liver	0.5	0.5	0.7	-0.8	0.8	-0.6	0.6	0.7	-0.7
Bone: minimum diameter	0.0	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	-0.2	0.1
Time in novel zone, hab. session 1	0.4	0.3	0.4	-0.6	0.6	-0.5	0.5	0.6	-0.6
Total zone transitions, hab. session 1	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	0.1	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.2	-0.5	0.5	-0.4	0.4	0.4	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	-0.0	0.0
Time in familiar zone, hab. session 2	2.1	2.2	2.6	1.6	-1.6	1.4	-1.4	-1.5	1.5
Time in novel zone, hab. session 2	3.1	3.1	3.7	-1.9	1.9	-1.6	1.6	1.8	-1.8
Total zone transitions, hab. session 2	1.0	1.3	1.5	-1.2	1.2	-1.1	1.1	1.0	-1.0
Total locomotion distance, hab. session 2	1.2	1.5	1.9	-1.4	1.4	-1.2	1.2	1.1	-1.1
Locomotion velocity, hab. session 2	1.4	1.9	2.1	-1.5	1.5	-1.4	1.4	1.2	-1.2
Novel to familiar place preference ratio	0.6	0.7	1.1	-1.1	1.1	-0.9	0.8	0.4	-0.4
Novelty place preference	0.7	0.7	1.3	-1.1	1.1	-0.9	0.9	0.4	-0.4
Time in novel zone, NPP test	0.7	0.7	1.3	-1.2	1.2	-0.9	0.8	0.4	-0.4
Total zone transitions, NPP test	0.2	0.3	0.4	0.6	-0.6	0.7	-0.6	-0.3	0.3
Total locomotion distance, NPP test	0.0	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	0.1
Locomotion velocity, NPP test	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.1	-0.1
Intraocular pressure	0.3	0.4	0.6	-0.8	0.8	-0.7	0.7	0.4	-0.4
Delta distance traveled before/after self-admin	0.2	0.2	0.3	0.4	-0.4	0.4	-0.4	-0.5	0.5
Delta ambulatory time before/after self-admin	0.4	0.5	0.5	0.6	-0.6	0.7	-0.7	-0.7	0.7
Parametrial fat weight	1.6	3.0	4.4	-1.8	1.8	-2.1	2.0	1.3	-1.3
Pavlov. Cond. lever latency	0.4	0.5	0.6	-0.8	0.8	-0.8	0.7	0.5	-0.4
Pavlov. Cond. magazine entry latency	1.8	2.3	2.8	1.6	-1.6	1.7	-1.7	-1.3	1.3
Pavlov. Cond. change in total contacts	1.2	1.3	1.7	-1.0	1.0	-1.1	1.1	1.3	-1.3
Pavlov. Cond. index score	1.9	2.5	3.0	1.7	-1.7	1.7	-1.7	-1.3	1.3
Pavlov. Cond. latency score	1.6	2.0	2.4	1.6	-1.6	1.5	-1.5	-1.2	1.1
Pavlov. Cond. lever contacts	0.6	0.8	1.1	1.0	-1.0	0.9	-0.9	-0.6	0.6
Pavlov. Cond. magazine entry number	2.0	2.5	3.0	-1.7	1.7	-1.7	1.7	1.4	-1.3
Pavlov. Cond. intertrial magazine entries	0.4	0.4	0.5	-0.5	0.5	-0.7	0.7	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.3	2.9	3.4	1.8	-1.8	1.8	-1.8	-1.4	1.4
Pavlov. Cond. response bias	0.8	0.9	1.3	1.1	-1.1	1.1	-1.1	-0.6	0.6
Pavlov. Cond. lever latency	4.0	5.4	6.2	-2.2	2.2	-2.3	2.4	2.5	-2.5
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.2	0.2	0.1	-0.1	0.0	-0.0
Pavlov. Cond. change in total contacts	0.2	0.3	0.6	0.3	-0.3	0.6	-0.6	-0.8	0.8
Pavlov. Cond. index score	1.3	1.7	2.0	1.1	-1.1	1.4	-1.4	-1.4	1.4
Pavlov. Cond. latency score	1.4	1.7	1.9	1.2	-1.2	1.4	-1.4	-1.4	1.3
Pavlov. Cond. lever contacts	3.6	4.9	5.7	2.1	-2.1	2.1	-2.2	-2.4	2.4
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	-0.1	-0.2	0.2	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.0	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	1.8	1.1	-1.1	1.3	-1.4	-1.3	1.3
Pavlov. Cond. response bias	1.4	2.0	2.6	1.2	-1.2	1.4	-1.4	-1.6	1.6
Time in closed arm before self-admin	0.5	0.5	0.7	-0.6	0.6	-0.7	0.7	0.9	-0.8
Time in closed arm after self-admin	2.0	2.1	2.4	1.5	-1.5	1.5	-1.5	-1.3	1.3
Time in open arm before self-admin	2.7	3.0	3.1	1.7	-1.7	1.8	-1.8	-1.7	1.7
Time in open arm after self-admin	0.1	0.1	0.2	-0.3	0.3	-0.5	0.5	0.1	-0.1
Bone: periosteal estimation	1.0	2.1	2.2	-1.5	1.5	-1.5	1.5	1.4	-1.4
Bone: periosteal perimeter	1.9	3.2	3.5	-1.9	1.9	-1.9	1.9	1.6	-1.6
Bone: post-yield work	0.2	0.3	0.4	-0.6	0.6	-0.5	0.5	0.5	-0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	-0.4	0.3	-0.3	-0.4	0.4
Progressive ratio test 1 inactive lever presses	2.5	2.7	3.0	-1.7	1.7	-1.7	1.7	1.5	-1.5
Progressive ratio test 2 active lever presses	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	0.1	-0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	0.1	-0.2	0.2	0.1	-0.1
Progressive ratio test 2 inactive lever presses	0.5	0.6	0.8	-0.9	0.9	-0.9	0.9	0.5	-0.5
Incentive Sensitization - Responses	0.0	0.0	0.1	-0.3	0.3	-0.1	0.1	-0.0	0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.2	0.2	-0.0	0.0	-0.1	0.1
Sum of active levers in priming session hrs 5-6	1.1	1.0	1.1	-1.0	1.0	-1.0	1.0	1.0	-1.1
Progressive ratio	0.1	0.2	0.4	0.6	-0.6	0.3	-0.3	-0.2	0.2
Food seeking constrained by brief footshock	2.2	2.7	3.6	-1.3	1.3	-1.6	1.7	1.9	-1.9
Seeking ratio, punishment vs. effort	1.3	1.6	1.8	-1.3	1.3	-1.2	1.2	1.3	-1.3
Retroperitoneal fat weight	0.0	0.1	0.1	0.3	-0.3	-0.0	0.0	-0.2	0.2
Reaction time number correct	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	0.1	-0.1
Reaction time mean minus median	1.8	2.4	3.3	1.2	-1.2	1.5	-1.5	-1.8	1.8
Reaction time mean minus median AUC	1.4	1.8	2.2	1.1	-1.1	1.4	-1.4	-1.5	1.5
Reaction time num false alarms	0.4	0.5	1.2	-0.2	0.2	-0.5	0.6	1.1	-1.1
Reaction time num false alarms AUC	0.3	0.5	1.2	-0.0	0.0	-0.4	0.5	1.1	-1.1
Reaction time trials correct on left	0.0	0.0	0.1	-0.3	0.3	-0.2	0.2	0.1	-0.1
Reaction time trials on left	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	0.1	-0.1
Reaction time mean	0.9	1.3	1.6	1.1	-1.1	1.0	-1.1	-1.3	1.3
Reaction time mean AUC	1.5	2.0	2.3	1.4	-1.4	1.3	-1.3	-1.5	1.5
Median of all reaction times	0.5	0.7	0.8	0.9	-0.9	0.7	-0.7	-0.9	0.9
Reaction time omissions	1.4	1.9	2.2	1.5	-1.5	1.4	-1.4	-1.2	1.2
Reaction time false alarm rate	0.3	0.4	1.0	0.1	-0.1	-0.3	0.4	1.0	-1.0
Reaction time premature initiation rate	2.7	3.6	4.2	2.0	-2.0	2.0	-2.0	-1.6	1.6
Reaction time premature initiations	1.4	1.9	2.3	1.4	-1.4	1.5	-1.5	-1.2	1.2
Std. dev. reaction times	1.6	2.2	3.0	1.3	-1.3	1.4	-1.4	-1.7	1.7
Reaction time trials completed	0.0	0.0	0.1	-0.2	0.2	-0.1	0.1	0.1	-0.1
Reaction time trials AUC	0.1	0.1	0.1	-0.4	0.4	-0.3	0.3	0.2	-0.2
Run reversals in cocaine runway, females	0.6	0.6	0.9	0.9	-0.9	0.7	-0.7	-0.7	0.7
Run reversals in cocaine runway, males	0.4	0.4	0.5	-0.7	0.7	-0.6	0.6	0.6	-0.6
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.2	-0.2	-0.2	0.2	0.5	-0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	1.1	-0.6	0.6	-0.7	0.7	1.0	-1.0
Latency to leave start box in cocaine runway, M	0.9	0.9	1.4	1.2	-1.2	0.8	-0.8	-0.8	0.8
Std. dev. time between licks in bursts	0.0	0.0	0.0	-0.1	0.1	-0.0	0.0	-0.0	0.0
Total sessions with >9 infusions	0.0	0.0	0.0	0.2	-0.2	0.2	-0.1	0.1	-0.1
Short access day 1 total inactive lever presses	3.3	3.7	4.5	-1.6	1.6	-2.0	2.0	2.1	-2.1
Short access day 10 total inactive lever presses	0.2	0.2	0.2	0.4	-0.4	0.5	-0.5	-0.4	0.4
Short access day 1 total infusions	0.2	0.2	0.3	0.5	-0.5	0.6	-0.5	-0.4	0.4
Short access day 10 total infusions	0.3	0.3	0.4	0.7	-0.7	0.5	-0.5	-0.4	0.4
Short access total infusions	0.3	0.3	0.5	0.7	-0.7	0.6	-0.6	-0.3	0.4
Short access day 1 locomotion	1.4	1.5	2.0	1.4	-1.4	1.3	-1.3	-0.9	0.9
Short access day 10 total locomotion	0.5	0.6	0.8	0.9	-0.9	0.7	-0.7	-0.7	0.7
Short access total locomotion	3.3	3.4	4.0	2.0	-2.0	1.9	-1.9	-1.6	1.6
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	-0.3	0.0	0.0	-0.0	0.0
Compulsive drug intake	2.3	2.4	2.8	1.5	-1.5	1.7	-1.7	-1.5	1.5
One hour access (shock baseline)	0.5	0.6	0.9	-0.6	0.6	-1.0	1.0	0.8	-0.8
Social response proportion	1.8	2.0	2.8	-1.7	1.7	-1.6	1.5	0.9	-0.9
Social responses	2.4	3.0	3.8	-1.9	1.9	-1.8	1.8	1.4	-1.4
Social time	0.2	0.3	0.4	-0.6	0.6	-0.6	0.6	0.3	-0.3
Soleus weight	0.8	2.2	2.6	-1.4	1.4	-1.5	1.5	1.6	-1.6
Bone: stiffness	0.0	0.0	0.0	-0.1	0.1	0.1	-0.1	-0.2	0.2
Tibialis anterior weight	1.2	4.1	4.3	-2.1	2.1	-2.0	2.0	2.0	-1.9
Time to tail flick, vehicle, before self-admin	0.0	0.0	0.1	0.3	-0.3	0.1	-0.0	-0.0	-0.0
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	0.1	-0.1	-0.1	0.1	0.3	-0.3
Time to tail flick, test, before self-admin	0.7	0.7	0.9	0.7	-0.7	0.9	-0.9	-0.8	0.8
Time to tail flick, test, after self-admin	3.4	3.5	4.2	-1.7	1.7	-1.9	1.9	2.0	-2.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	-0.0	0.1
Delta time to tail flick, test, before/after SA	2.5	2.3	2.5	-1.4	1.4	-1.6	1.6	1.5	-1.5
Tibia length	0.1	0.2	0.4	0.6	-0.6	0.3	-0.3	-0.1	0.1
Ambulatory time before self-admin	0.7	0.7	1.3	-0.6	0.6	-0.7	0.7	1.2	-1.1
Ambulatory time after self-admin	0.3	0.4	0.6	-0.4	0.4	-0.5	0.6	0.8	-0.8
Bone: tissue strength	0.0	0.0	0.1	-0.3	0.3	-0.1	0.0	-0.1	0.1
Total heroin consumption	0.1	0.1	0.1	-0.1	0.1	-0.3	0.3	0.3	-0.3
Bone: trabecular number	0.0	0.1	0.1	0.4	-0.4	0.3	-0.2	0.1	-0.1
Bone: trabecular spacing	1.1	1.4	2.0	-1.4	1.4	-1.2	1.2	0.9	-0.9
Bone: trabecular thickness	1.1	1.3	2.0	1.4	-1.4	1.2	-1.1	-0.8	0.8
Bone: trabecular tissue density	0.3	0.4	0.9	0.3	-0.3	0.5	-0.6	-0.9	1.0
Water consumed over 24 hours	1.5	1.7	2.6	-1.6	1.6	-1.3	1.2	1.0	-1.0
Number of responses in last shaping day	0.0	0.0	0.1	0.3	-0.3	0.1	-0.1	0.1	-0.1