Hub : Genes

Cbx8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Cbx8	0.03	0.02	4.0e-03	0.02	0.02	0.01	0.01	9.3e-04	2.4e-03	1.9e-02	1.3e-02
2	Brain	gene expression	Cbx8	0.03	0.02	2.5e-03	0	0.03	0.02	0.01	1.5e-01	1.1e-03	5.4e-03	1.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.1	0.2	0.4	-0.1	-0.6
Area under the delay curve	1.6	1.7	2.4	1.5	1.0
BMI with tail	0.3	0.8	1.6	-1.3	-0.1
BMI without tail	3.2	6.6	12.2	-3.5	1.0
Body weight	4.0	16.9	21.8	-4.7	3.5
Weight adjusted by age	3.3	3.7	5.4	-2.3	1.4
Bone surface	0.3	0.5	1.0	-0.3	1.0
Bone volume	0.0	0.1	0.1	-0.3	0.3
Breakpoint value in progressive ratio session	0.4	0.4	0.8	-0.9	-0.0
Number of licking bursts	0.3	0.3	0.3	-0.6	0.5
Context. condit. distance diff. score	0.4	0.5	0.6	-0.6	0.8
Locomotion velocity, session 1	2.2	2.4	4.8	2.2	-0.2
Locomotion distance, session 1	2.3	2.9	3.1	1.6	-1.8
Locomotion velocity, session 2	4.9	5.7	7.2	2.7	-2.0
Locomotion distance, session 2	1.6	2.3	4.3	0.4	-2.1
Locomotion velocity, session 3	1.2	1.4	2.8	1.7	-0.2
Locomotion distance, session 3	3.5	3.8	5.4	2.3	-1.5
Stereotopy head waving bouts, day 3	0.3	0.3	0.5	0.7	0.3
Stereotopy head waving duration, day 3	0.3	0.3	0.4	0.5	0.6
Locomotion velocity, session 7	0.6	0.6	1.3	1.1	0.0
Locomotion distance, session 7	2.8	3.6	4.4	2.1	-1.7
Stereotopy head waving bouts, day 7	1.0	1.2	2.1	-0.5	1.5
Stereotopy head waving duration, day 7	2.0	2.4	4.1	-0.9	2.0
Locomotion velocity, session 8	0.7	0.8	1.3	0.5	1.2
Locomotion distance, session 8	0.3	0.5	0.7	-0.5	-0.8
Degree of sensitization distance	0.4	0.4	0.9	-0.9	-0.1
Degree of sensitization stereotypy	1.1	1.2	1.6	-0.9	1.2
Conditioned locomotion	2.5	3.0	5.0	-2.2	0.9
Cocaine response after cond. corrected	0.1	0.1	0.2	0.5	-0.0
Cocaine response after cond. not corrected	0.5	0.6	1.1	1.1	-0.1
Cocaine response before conditioning	0.4	0.5	1.0	1.0	0.0
Saline control response	3.3	4.3	5.0	-2.2	1.9
Bone: connectivity density	0.1	0.1	0.2	0.3	-0.4
Bone: cortical apparent density	4.1	5.4	6.1	2.2	-2.5
Bone: cortical area	5.8	8.7	12.3	-3.5	2.3
Bone: cortical porosity	0.7	0.8	1.2	-0.6	1.1
Bone: cortical porosity	1.3	1.4	2.1	-0.9	1.5
Bone: cortical thickness	3.6	5.9	10.9	-3.3	1.0
Bone: cortical thickness	1.2	1.4	2.6	-1.6	0.6
Bone: cortical tissue density	4.6	6.1	6.6	2.4	-2.6
Condit. Reinf. active minus inactive responses	1.6	1.8	3.3	-1.8	0.5
Condit. Reinf. active-inactive response ratio	0.7	0.7	1.4	-1.2	0.3
Condit. Reinf. active responses	2.8	3.4	6.4	-2.5	0.6
Condit. Reinf. inactive responses	0.7	0.8	1.6	-1.2	0.0
Incentive salience index mean	1.5	1.8	3.4	-1.8	0.5
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	-0.2
Condit. Reinf. active minus inactive responses	1.8	2.3	3.1	-1.2	1.7
Condit. Reinf. active-inactive response ratio	2.6	2.7	2.8	-1.7	1.6
Condit. Reinf. active responses	0.3	0.4	0.5	-0.6	0.7
Condit. Reinf. inactive responses	0.5	0.6	0.7	0.8	-0.8
Condit. Reinf. lever presses	0.1	0.2	0.3	-0.5	-0.2
Condit. Reinf. lever reinforcers received	0.2	0.2	0.3	-0.5	0.4
Conditioned reinforcement - actives	0.4	0.4	0.8	-0.9	-0.3
Conditioned reinforcement - inactives	1.3	1.5	2.2	-1.5	0.9
Conditioned locomotion	0.6	0.7	1.3	-1.1	-0.3
Patch foraging indifference point 0 sec	0.5	0.8	0.9	-0.8	-0.9
Patch foraging indifference point AUC	0.0	0.0	0.0	0.1	-0.1
Delay disc. indifference point, 0s delay	1.0	1.1	2.2	0.0	1.5
Delay disc. indifference point, 16s delay	0.9	0.9	1.6	1.3	-0.4
Delay disc. indifference point, 2s delay	0.8	0.9	1.5	0.6	1.2
Delay disc. indifference point, 24s delay	3.9	3.7	6.6	2.6	-1.0
Delay disc. indifference point, 4s delay	1.6	1.6	2.9	0.7	1.7
Delay disc. indifference point, 8s delay	2.2	2.3	2.9	1.3	1.7
Indifference point function ln k	1.4	1.9	2.7	1.1	-1.6
Indifference point function log k	1.4	1.9	2.7	1.1	-1.6
Patch foraging total patch changes 0 sec	0.6	1.0	1.3	-0.8	-1.1
Patch foraging total patch changes 12 sec	0.5	0.7	1.4	-0.2	-1.2
Patch foraging total patch changes 18 sec	0.2	0.2	0.5	0.0	-0.7
Patch foraging total patch changes 24 sec	1.2	1.5	2.2	-1.5	0.9
Patch foraging total patch changes 6 sec	0.6	0.9	1.0	-1.0	-0.9
Patch foraging time to switch 0 sec	0.5	0.8	1.6	1.3	-0.1
Patch foraging water rate 0 sec	2.8	4.5	8.0	-2.8	1.0
Patch foraging water rate 12 sec	0.6	0.9	1.0	-0.9	-1.0
Patch foraging water rate 18 sec	0.9	1.3	2.5	-1.6	0.1
Patch foraging water rate 24 sec	2.0	2.8	5.7	-2.4	0.1
Patch foraging water rate 6 sec	0.3	0.4	0.7	-0.8	-0.2
Seeking ratio, delayed vs. immediate footshock	1.1	1.2	1.9	-1.4	0.8
Distance traveled before self-admin	1.9	2.0	2.8	-1.1	1.7
Distance traveled after self-admin	0.5	0.6	1.0	-1.0	-0.5
Extensor digitorum longus weight	0.3	1.3	2.5	-0.2	-1.6
Bone: elastic displacement	1.0	1.2	2.1	-1.5	-0.5
Bone: elastic work	4.0	5.2	9.4	-3.1	1.0
Bone: endosteal estimation	0.1	0.3	0.5	0.2	0.7
Bone: endosteal perimeter	1.8	3.7	5.5	-1.4	2.4
Epididymis fat weight	1.0	2.3	3.8	-1.9	0.9
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	-0.2	0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.2	-0.5	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.1
Delay discount exponential model param	2.1	2.2	3.5	-1.9	-1.0
Extinction: sum of active levers before priming	1.2	1.2	1.2	1.1	-1.1
Active lever presses in extinction session 6	0.1	0.1	0.1	-0.4	0.2
Bone: final force	4.7	7.5	9.5	-3.1	2.4
Bone: final moment	5.3	8.6	11.3	-3.4	2.4
Food consumed during 24 hour testing period	1.1	1.3	1.4	-1.1	1.2
Glucose	3.4	5.1	6.7	2.6	-1.9
Heart weight	0.2	0.3	0.6	-0.8	-0.3
Delay discount hyperbolic model param	2.0	2.1	3.1	-1.8	-1.1
Intermittent access intake day 1-15 change	0.5	0.5	0.7	-0.4	0.9
Intermittent access intake escalation	0.6	0.5	0.8	-0.6	0.9
Intermittent access intake escalation 2	0.9	0.9	1.1	-0.8	1.1
Intermitt. access day 1 inactive lever presses	2.3	2.5	2.5	-1.6	1.6
Intermitt. access day 15 inactive lever presses	1.6	1.7	3.1	-1.8	0.6
Intermitt. access escalation Index	1.8	1.6	2.2	-1.5	1.0
Intermittent access day 1 total infusions	0.3	0.4	0.5	-0.7	-0.4
Intermittent access day 15 total infusions	0.6	0.7	1.2	-1.1	0.4
Intermittent access terminal intake (last 3 days)	1.0	1.0	1.7	-1.3	0.6
Intermittent access total infusions	0.5	0.6	1.1	-1.1	0.1
Intermittent access day 1 locomotion	0.6	0.6	1.2	-1.1	-0.3
Intermittent access day 15 total locomotion	0.4	0.4	0.8	-0.9	0.3
Intermittent access total locomotion	0.5	0.6	1.1	-1.1	0.0
Intermittent access standard deviation	0.7	0.8	1.3	0.5	1.1
Left kidney weight	1.0	2.7	5.2	-0.4	2.3
Right kidney weight	0.6	1.6	3.1	-0.4	1.7
Cocaine induced anxiety	4.8	5.6	6.0	-2.3	2.5
Post-drug Anxiety	1.1	1.3	2.2	-0.6	1.5
Baseline Anxiety	5.6	5.9	8.9	3.0	-1.7
Tail length	6.1	18.4	25.2	-5.0	3.4
Length with tail	4.2	15.5	16.9	-3.7	4.1
Length without tail	0.7	1.6	3.1	0.3	1.8
Times rat made contact with spout	1.0	1.2	2.4	-1.5	0.3
Lifetime Intake	0.2	0.2	0.4	-0.6	0.0
Liver weight, left	0.4	0.7	1.3	0.2	1.1
Liver weight, right	2.7	4.5	5.1	-2.3	2.0
Locomotor activity	0.2	0.3	0.5	0.7	-0.4
Locomotor testing distance	0.1	0.1	0.2	0.4	-0.1
Locomotor testing rearing	0.1	0.1	0.2	-0.4	-0.2
Locomotion in novel chamber	0.0	0.0	0.0	-0.2	0.2
Locomotion in novel chamber post-restriction	0.5	0.5	1.0	-1.0	0.3
Fecal boli incidents, locomotor time 1	1.1	1.2	2.2	0.4	-1.5
Change in fecal boli incidents, locomotor task	3.8	3.6	5.3	2.3	-1.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.1	0.4
Bouts of movement, locomotor time 1	2.5	2.7	2.9	1.7	-1.6
Total resting periods, locomotor time 1	3.2	3.5	3.6	1.9	-1.9
Rest time, locomotor task time 1	0.4	0.5	0.7	0.4	-0.9
Distance moved, locomotor task time 1	0.8	0.8	1.1	-0.8	1.0
Vertical activity count, locomotor time 1	0.7	0.7	1.2	-1.1	0.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.2	-0.1
Bouts of movement, locomotor time 2	1.3	1.4	2.4	1.5	-0.7
Total resting periods, locomotor time 2	0.8	0.8	1.4	1.2	-0.5
Rest time, locomotor task time 2	0.0	0.1	0.1	0.3	-0.1
Distance moved, locomotor task time 2	0.3	0.3	0.5	-0.4	0.7
Vertical activity count, locomotor time 2	0.3	0.3	0.4	-0.6	0.4
Light reinforcement 1	1.1	1.9	3.8	-2.0	-0.3
Light reinforcement 2	2.0	2.6	4.1	-2.0	1.1
Bone: marrow area	0.2	0.3	0.6	0.3	0.8
Bone: maximum diameter	3.6	6.7	8.7	-2.1	3.0
Bone: maximum force	4.1	7.1	10.0	-3.2	2.1
Bone: maximum moment	4.7	8.0	11.8	-3.4	2.1
Mean time between licks in bursts	0.9	1.3	2.1	1.5	-0.7
Mean num. licks in bursts	0.3	0.3	0.4	-0.5	-0.6
Cd content in liver	1.7	1.8	2.1	1.2	-1.4
Co content in liver	0.5	0.6	1.2	0.0	-1.1
Cu content in liver	0.0	0.0	0.1	-0.3	-0.1
Fe content in liver	0.6	0.7	1.3	1.1	-0.2
K content in liver	1.8	1.8	3.0	-1.7	0.8
Mg content in liver	0.4	0.4	0.7	-0.5	-0.8
Mn content in liver	0.9	1.0	1.7	-0.5	1.3
Na content in liver	0.2	0.2	0.4	-0.1	0.6
Rb content in liver	0.6	0.8	1.5	-1.2	-0.2
Se content in liver	0.3	0.4	0.5	-0.5	0.7
Sr content in liver	0.2	0.2	0.3	0.3	-0.6
Zn content in liver	0.0	0.0	0.0	0.0	0.0
Bone: minimum diameter	3.8	7.1	8.6	-2.9	2.4
Time in familiar zone, hab. session 1	0.4	0.3	0.6	0.3	-0.8
Time in novel zone, hab. session 1	0.7	0.7	1.3	-0.1	1.2
Total zone transitions, hab. session 1	0.5	0.7	1.2	0.5	-1.1
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.8	-0.4
Locomotion velocity, hab. session 1	0.4	0.6	0.8	-0.9	-0.6
Time in familiar zone, hab. session 2	0.2	0.2	0.2	0.4	-0.4
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	0.2
Total zone transitions, hab. session 2	1.4	1.8	3.6	0.2	-1.9
Total locomotion distance, hab. session 2	1.3	1.7	2.2	-1.1	-1.5
Locomotion velocity, hab. session 2	1.3	1.8	1.9	-1.4	-1.3
Novel to familiar place preference ratio	1.3	1.3	2.2	-1.5	-0.7
Novelty place preference	1.1	1.1	2.0	-1.4	-0.5
Time in novel zone, NPP test	1.1	1.1	1.7	-1.3	-0.7
Total zone transitions, NPP test	0.8	1.2	2.2	0.3	-1.5
Total locomotion distance, NPP test	1.6	2.2	4.0	-0.7	-2.0
Locomotion velocity, NPP test	1.3	1.9	3.1	-0.8	-1.8
Intraocular pressure	0.3	0.4	0.4	-0.6	-0.6
Delta distance traveled before/after self-admin	1.0	1.1	2.1	-0.0	-1.5
Delta ambulatory time before/after self-admin	1.6	1.7	3.2	0.5	-1.8
Parametrial fat weight	1.3	2.5	4.1	-2.0	0.9
Pavlov. Cond. lever latency	0.6	0.7	1.2	1.1	-0.5
Pavlov. Cond. magazine entry latency	3.1	3.9	4.3	-1.9	2.1
Pavlov. Cond. change in total contacts	0.3	0.4	0.6	-0.4	-0.8
Pavlov. Cond. index score	3.3	4.1	5.1	-2.3	1.8
Pavlov. Cond. latency score	2.6	3.3	3.8	-1.9	1.7
Pavlov. Cond. lever contacts	0.5	0.6	1.2	-1.1	0.0
Pavlov. Cond. magazine entry number	2.2	2.8	3.5	1.5	-1.9
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.2	-0.3	-1.1
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.0	5.3	-2.3	1.7
Pavlov. Cond. response bias	1.7	2.0	2.5	-1.6	1.3
Pavlov. Cond. lever latency	0.5	0.7	1.4	1.2	0.2
Pavlov. Cond. magazine entry latency	1.3	1.6	2.0	1.1	-1.4
Pavlov. Cond. change in total contacts	0.5	0.6	1.2	0.1	-1.1
Pavlov. Cond. index score	0.3	0.3	0.6	-0.1	-0.8
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.2	-0.6
Pavlov. Cond. lever contacts	0.7	1.0	2.0	-1.4	0.1
Pavlov. Cond. magazine entry number	1.2	1.5	2.3	-0.8	1.5
Pavlov. Cond. intertrial magazine entries	2.3	3.0	3.1	-1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.9	0.1	-1.0
Pavlov. Cond. response bias	0.2	0.3	0.3	-0.5	-0.6
Time in closed arm before self-admin	0.7	0.8	1.2	1.1	-0.6
Time in closed arm after self-admin	1.1	1.1	2.2	1.5	0.1
Time in open arm before self-admin	0.1	0.1	0.2	-0.2	0.5
Time in open arm after self-admin	0.0	0.0	0.1	-0.1	-0.2
Bone: periosteal estimation	2.0	4.2	4.3	-2.1	2.0
Bone: periosteal perimeter	4.2	7.0	7.2	-2.6	2.7
Bone: post-yield work	0.3	0.4	0.8	-0.1	-0.9
Progressive ratio test 1 active lever presses	0.8	0.8	1.7	-1.3	0.1
Progressive ratio test 1 breakpoint	0.9	1.0	1.9	-1.4	0.0
Progressive ratio test 1 inactive lever presses	3.4	3.7	5.5	-2.3	1.4
Progressive ratio test 2 active lever presses	0.3	0.3	0.7	-0.8	0.1
Progressive ratio test 2 breakpoint	0.4	0.4	0.8	-0.9	0.1
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.0	-1.0	0.6
Incentive Sensitization - Responses	0.0	0.0	0.0	-0.1	0.2
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.1	0.3
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	-0.8	-0.1
Progressive ratio	0.7	0.8	1.3	0.6	-1.1
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.3	0.0
Seeking ratio, punishment vs. effort	0.5	0.6	1.1	-0.3	1.0
Retroperitoneal fat weight	5.2	16.9	23.6	-4.9	3.2
Reaction time number correct	0.4	0.6	0.9	-1.0	-0.5
Reaction time mean minus median	0.1	0.1	0.2	0.5	0.1
Reaction time mean minus median AUC	0.4	0.6	1.0	-0.3	1.0
Reaction time num false alarms	0.4	0.5	0.6	0.8	-0.7
Reaction time num false alarms AUC	0.6	0.8	1.1	1.0	-0.8
Reaction time trials correct on left	0.4	0.6	0.9	-1.0	-0.5
Reaction time trials on left	0.4	0.6	0.9	-1.0	-0.5
Reaction time mean	0.1	0.1	0.2	-0.4	0.4
Reaction time mean AUC	0.1	0.1	0.2	-0.4	0.2
Median of all reaction times	0.1	0.2	0.2	-0.4	0.4
Reaction time omissions	0.6	0.8	1.4	-0.6	1.2
Reaction time false alarm rate	0.8	1.1	2.0	1.4	-0.5
Reaction time premature initiation rate	2.8	3.7	5.3	1.5	-2.3
Reaction time premature initiations	2.1	3.0	5.5	0.7	-2.3
Std. dev. reaction times	0.3	0.4	0.7	0.8	-0.3
Reaction time trials completed	0.4	0.6	0.9	-1.0	-0.5
Reaction time trials AUC	0.5	0.7	1.1	-1.0	-0.6
Run reversals in cocaine runway, females	0.6	0.6	1.0	1.0	-0.5
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.7	0.0
Latency to leave start box in cocaine runway	1.1	1.2	1.7	0.8	-1.3
Latency to leave start box in cocaine runway, F	0.4	0.4	0.7	0.4	-0.8
Latency to leave start box in cocaine runway, M	1.2	1.1	2.2	0.3	-1.5
Std. dev. time between licks in bursts	0.2	0.3	0.5	-0.7	0.2
Total sessions with >9 infusions	0.2	0.2	0.4	0.6	-0.1
Short access day 1 total inactive lever presses	0.4	0.4	0.5	-0.7	0.6
Short access day 10 total inactive lever presses	3.7	4.1	4.4	-2.1	1.9
Short access day 1 total infusions	0.9	1.0	1.7	1.3	-0.4
Short access day 10 total infusions	0.5	0.6	1.0	-1.0	0.4
Short access total infusions	0.1	0.1	0.1	0.0	-0.4
Short access day 1 locomotion	0.2	0.2	0.5	0.7	-0.0
Short access day 10 total locomotion	0.1	0.2	0.3	0.6	0.0
Short access total locomotion	0.4	0.5	0.8	0.9	-0.4
One hour access (0.3 mA shock)	0.9	1.1	2.1	-1.5	0.1
Compulsive drug intake	0.3	0.3	0.6	-0.7	0.0
One hour access (shock baseline)	0.3	0.4	0.7	-0.8	0.2
Social response proportion	0.1	0.1	0.1	0.3	-0.3
Social responses	0.1	0.1	0.2	-0.4	0.3
Social time	0.2	0.3	0.6	0.2	-0.8
Soleus weight	0.9	2.6	5.2	-2.3	-0.2
Bone: stiffness	0.7	1.2	1.7	-0.8	1.3
Tibialis anterior weight	0.2	0.7	1.3	0.2	-1.1
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.1	-0.4	-0.3
Time to tail flick, vehicle, after self-admin	1.6	1.7	2.4	1.5	-1.0
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.2	0.2
Time to tail flick, test, after self-admin	0.4	0.4	0.9	0.1	0.9
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.2	-0.5
Delta time to tail flick, test, before/after SA	0.3	0.2	0.3	0.6	0.4
Tibia length	14.0	39.4	51.9	-5.2	7.2
Ambulatory time before self-admin	3.5	3.7	4.7	-1.6	2.2
Ambulatory time after self-admin	0.5	0.5	1.0	-1.0	0.1
Bone: tissue strength	1.2	1.2	2.3	-1.5	-0.3
Total heroin consumption	0.4	0.5	0.9	-0.3	1.0
Bone: trabecular number	0.1	0.1	0.1	0.4	-0.3
Bone: trabecular spacing	1.0	1.3	1.3	-1.1	1.2
Bone: trabecular thickness	0.3	0.4	0.7	-0.1	-0.9
Bone: trabecular tissue density	0.4	0.5	1.0	1.0	0.0
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	-0.1
Number of responses in last shaping day	2.0	2.0	2.4	-1.5	1.3