Cbx2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	Cbx2	0.06	0.03	1.1e-08	0.07	0.06	0.07	0.07	4.1e-08	1.4e-07	4.0e-08	2.9e-08
2	Brain	isoform ratio	NM_001107071.2	0.04	0.03	7.2e-03	0.02	0.02	0.02	0.03	1.1e-02	1.2e-02	4.3e-03	2.0e-03
3	Adipose	isoform ratio	NM_001107071.2	0.03	0.02	2.0e-04	0.04	0.04	0.03	0.04	8.2e-05	7.1e-05	6.5e-04	5.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3
Bone: apparent density	0.5	0.9	1.5	1.2	-0.9	-0.7
Area under the delay curve	1.0	1.2	3.5	-1.9	0.1	0.1
BMI with tail	0.1	0.2	0.6	0.2	0.8	-0.3
BMI without tail	0.1	0.3	0.5	0.4	0.7	0.4
Body weight	1.2	5.1	7.6	-1.8	2.8	2.1
Weight adjusted by age	0.4	0.6	0.7	-0.8	0.8	0.8
Bone surface	0.1	0.1	0.3	-0.2	0.1	0.6
Bone volume	0.1	0.3	0.6	0.8	-0.4	-0.2
Breakpoint value in progressive ratio session	0.4	0.4	0.7	0.4	-0.9	-0.6
Number of licking bursts	0.1	0.1	0.2	-0.4	0.4	0.3
Context. condit. distance diff. score	0.7	0.9	1.3	0.4	-1.1	-1.1
Locomotion velocity, session 1	0.9	1.0	1.7	-1.3	0.9	0.7
Locomotion distance, session 1	1.1	1.4	1.8	0.9	-1.3	-1.3
Locomotion velocity, session 2	0.3	0.4	0.4	0.5	-0.6	-0.6
Locomotion distance, session 2	1.4	2.0	2.8	1.7	-1.2	-1.3
Locomotion velocity, session 3	0.2	0.2	0.5	-0.7	0.2	0.2
Locomotion distance, session 3	0.3	0.4	0.7	0.2	-0.6	-0.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.2	0.3	0.0
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	-0.2	-0.4
Locomotion velocity, session 7	0.4	0.4	0.8	-0.1	-0.9	-0.6
Locomotion distance, session 7	5.5	7.0	8.6	2.2	-2.9	-2.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.8	0.5	0.3
Stereotopy head waving duration, day 7	0.9	1.0	1.4	-1.2	1.0	0.8
Locomotion velocity, session 8	0.7	0.9	1.6	-0.2	-1.3	-1.0
Locomotion distance, session 8	3.6	5.2	5.8	2.1	-2.3	-2.4
Degree of sensitization distance	2.4	2.5	3.0	1.7	-1.7	-1.2
Degree of sensitization stereotypy	0.0	0.0	0.1	-0.3	0.1	-0.1
Conditioned locomotion	0.0	0.1	0.1	0.4	-0.1	0.1
Cocaine response after cond. corrected	0.0	0.0	0.1	-0.1	-0.0	-0.3
Cocaine response after cond. not corrected	0.0	0.1	0.1	-0.2	-0.2	-0.3
Cocaine response before conditioning	0.1	0.1	0.3	-0.3	-0.5	-0.0
Saline control response	0.5	0.7	0.8	-0.7	0.9	0.9
Bone: connectivity density	0.4	0.7	1.2	0.6	-1.1	-0.6
Bone: cortical apparent density	1.0	1.3	1.6	1.1	-1.1	-1.3
Bone: cortical area	5.6	8.6	10.9	-2.5	3.3	2.9
Bone: cortical porosity	1.4	1.5	2.0	-0.9	1.3	1.4
Bone: cortical porosity	1.8	2.0	2.3	-1.2	1.4	1.5
Bone: cortical thickness	5.9	9.7	14.7	-2.3	3.8	3.0
Bone: cortical thickness	2.0	2.4	3.0	-1.5	1.7	1.4
Bone: cortical tissue density	1.1	1.5	1.7	1.2	-1.1	-1.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.2	0.2	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	-0.5	0.1
Condit. Reinf. active responses	0.4	0.4	0.9	-0.3	0.6	0.9
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.0	0.5	0.3
Incentive salience index mean	0.3	0.4	0.7	-0.5	0.4	0.8
Condit. Reinf. lever presses	0.1	0.1	0.1	0.3	-0.3	-0.3
Condit. Reinf. active minus inactive responses	0.6	0.8	1.8	-1.3	0.4	0.7
Condit. Reinf. active-inactive response ratio	1.6	1.9	2.2	-1.4	1.3	1.5
Condit. Reinf. active responses	0.3	0.4	0.7	0.0	-0.9	-0.6
Condit. Reinf. inactive responses	2.1	2.7	3.5	1.4	-1.9	-1.7
Condit. Reinf. lever presses	2.1	2.8	3.2	1.6	-1.8	-1.6
Condit. Reinf. lever reinforcers received	0.8	1.2	1.8	0.6	-1.4	-1.1
Conditioned reinforcement - actives	0.7	1.3	2.0	1.4	-0.5	-1.2
Conditioned reinforcement - inactives	0.2	0.3	0.5	0.3	0.7	0.5
Conditioned locomotion	0.5	0.7	1.7	1.3	-0.2	-0.5
Patch foraging indifference point 0 sec	1.0	1.9	3.9	2.0	-1.0	-1.0
Patch foraging indifference point AUC	0.1	0.2	0.5	0.2	-0.7	-0.2
Delay disc. indifference point, 0s delay	0.8	0.8	2.3	-1.5	0.4	0.0
Delay disc. indifference point, 16s delay	0.8	0.9	1.5	0.1	-1.2	-1.2
Delay disc. indifference point, 2s delay	0.9	1.1	2.7	-1.6	0.4	0.5
Delay disc. indifference point, 24s delay	0.3	0.3	0.8	-0.9	0.3	-0.1
Delay disc. indifference point, 4s delay	1.2	1.2	3.7	-1.9	0.0	0.1
Delay disc. indifference point, 8s delay	2.8	3.3	7.5	-2.7	1.0	1.2
Indifference point function ln k	0.9	1.6	2.4	1.6	-0.6	-1.5
Indifference point function log k	0.9	1.6	2.4	1.6	-0.6	-1.5
Patch foraging total patch changes 0 sec	1.5	2.8	5.3	2.3	-1.3	-1.3
Patch foraging total patch changes 12 sec	0.6	0.8	1.8	1.3	-0.6	-0.4
Patch foraging total patch changes 18 sec	2.4	3.6	5.3	1.6	-2.3	-1.8
Patch foraging total patch changes 24 sec	0.0	0.0	0.0	-0.0	-0.0	0.1
Patch foraging total patch changes 6 sec	0.3	0.4	1.0	1.0	0.3	0.3
Patch foraging time to switch 0 sec	0.2	0.4	1.2	-1.1	0.1	0.1
Patch foraging water rate 0 sec	0.4	0.9	2.2	1.5	-0.5	-0.3
Patch foraging water rate 12 sec	1.2	2.5	4.0	2.0	-0.9	-1.7
Patch foraging water rate 18 sec	1.8	2.7	5.0	2.2	-1.0	-1.5
Patch foraging water rate 24 sec	4.7	6.5	9.5	3.1	-2.2	-2.3
Patch foraging water rate 6 sec	0.5	0.7	1.0	1.0	-0.5	-0.9
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.4	-1.2	0.6	0.2
Distance traveled before self-admin	0.3	0.4	0.4	-0.6	0.6	0.7
Distance traveled after self-admin	1.3	1.6	2.8	1.7	-1.1	-0.9
Extensor digitorum longus weight	0.9	3.4	3.9	2.0	-1.7	-1.9
Bone: elastic displacement	0.4	0.4	0.8	0.4	0.9	0.6
Bone: elastic work	4.1	5.3	8.2	-1.2	2.9	2.5
Bone: endosteal estimation	0.4	0.9	1.9	0.4	-1.4	-0.7
Bone: endosteal perimeter	1.1	2.3	3.2	-1.8	0.9	1.7
Epididymis fat weight	0.0	0.0	0.0	0.0	0.2	-0.1
Delta time in closed arm before/after self-admin	0.3	0.3	0.7	-0.8	0.3	0.1
Delta time in open arm before/after self-admin	0.7	0.7	1.2	1.1	-0.7	-0.6
Diff in mean of infusions in LGA sessions	0.1	0.1	0.1	-0.4	-0.1	0.3
Delay discount exponential model param	1.2	1.4	4.0	2.0	-0.1	-0.2
Extinction: sum of active levers before priming	0.5	0.5	0.8	0.9	-0.4	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.1	0.0	-0.1	0.4
Bone: final force	2.7	4.3	5.5	-1.8	2.3	2.0
Bone: final moment	2.7	4.4	6.0	-1.7	2.4	2.1
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.1	-0.5	0.6
Glucose	0.3	0.4	0.7	-0.5	0.8	0.4
Heart weight	1.3	2.0	3.4	-1.1	1.9	1.2
Delay discount hyperbolic model param	1.3	1.4	4.1	2.0	-0.2	-0.3
Intermittent access intake day 1-15 change	0.1	0.2	0.4	-0.5	0.7	0.0
Intermittent access intake escalation	0.1	0.2	0.4	-0.4	0.7	-0.0
Intermittent access intake escalation 2	0.4	0.5	0.8	-0.8	0.9	0.4
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.0	1.0	-0.1	0.4
Intermitt. access day 15 inactive lever presses	0.3	0.5	0.8	0.6	-0.9	-0.7
Intermitt. access escalation Index	0.1	0.1	0.1	-0.3	0.0	0.4
Intermittent access day 1 total infusions	0.4	0.6	1.3	1.1	0.1	-0.7
Intermittent access day 15 total infusions	0.2	0.3	0.5	0.3	0.7	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.7	0.0	0.9	-0.4
Intermittent access total infusions	0.3	0.3	0.5	0.4	0.5	-0.7
Intermittent access day 1 locomotion	0.2	0.2	0.6	0.8	0.1	0.0
Intermittent access day 15 total locomotion	0.2	0.3	0.8	0.2	0.9	0.2
Intermittent access total locomotion	0.2	0.2	0.5	0.7	0.5	-0.1
Intermittent access standard deviation	0.8	1.7	3.5	-1.9	1.2	0.4
Left kidney weight	0.7	3.2	4.4	-2.1	1.8	1.4
Right kidney weight	0.6	2.9	3.8	-1.9	1.7	1.4
Cocaine induced anxiety	2.3	3.2	3.4	-1.7	1.9	1.8
Post-drug Anxiety	0.6	0.6	0.9	-0.4	0.9	1.0
Baseline Anxiety	1.5	1.8	2.4	1.6	-1.3	-1.1
Tail length	1.4	5.3	7.5	-2.0	2.1	2.7
Length with tail	2.9	12.6	13.3	-3.6	3.4	3.6
Length without tail	2.4	7.8	9.5	-3.1	2.9	2.4
Times rat made contact with spout	0.5	0.6	1.4	0.3	0.5	1.2
Lifetime Intake	0.2	0.3	0.6	0.3	0.3	-0.8
Liver weight, left	0.1	0.1	0.2	-0.4	0.5	0.2
Liver weight, right	1.4	2.5	2.6	-1.5	1.6	1.6
Locomotor activity	0.4	0.6	0.8	0.9	-0.6	-0.9
Locomotor testing distance	0.9	1.7	2.0	1.2	-1.3	-1.4
Locomotor testing rearing	1.1	2.3	2.6	1.4	-1.6	-1.5
Locomotion in novel chamber	0.3	0.4	1.0	0.6	-1.0	-0.1
Locomotion in novel chamber post-restriction	0.4	0.6	1.3	0.6	0.4	1.1
Fecal boli incidents, locomotor time 1	0.2	0.3	0.7	0.5	-0.1	-0.8
Change in fecal boli incidents, locomotor task	0.6	0.6	0.6	0.7	-0.8	-0.8
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.0	0.4	-1.0	-0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.2	0.2	-0.3	-0.5
Total resting periods, locomotor time 1	0.2	0.2	0.3	0.6	-0.2	-0.4
Rest time, locomotor task time 1	0.3	0.3	0.7	0.2	0.9	0.4
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	-0.1	0.2
Vertical activity count, locomotor time 1	0.1	0.1	0.4	-0.0	-0.6	-0.1
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.0	0.4	-0.4
Bouts of movement, locomotor time 2	0.1	0.1	0.2	-0.2	-0.5	-0.1
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.2	-0.5	-0.0
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.4	0.3	0.5
Distance moved, locomotor task time 2	0.2	0.2	0.4	-0.6	0.6	0.1
Vertical activity count, locomotor time 2	0.0	0.0	0.1	-0.2	0.0	-0.3
Light reinforcement 1	0.4	0.9	1.6	1.3	-0.7	-0.7
Light reinforcement 2	0.4	0.7	0.8	-0.6	0.9	0.9
Bone: marrow area	0.4	0.9	2.0	0.4	-1.4	-0.8
Bone: maximum diameter	3.5	6.5	8.0	-2.8	2.3	2.5
Bone: maximum force	1.9	3.4	4.5	-1.5	2.1	1.9
Bone: maximum moment	1.9	3.4	4.9	-1.3	2.2	1.9
Mean time between licks in bursts	0.0	0.0	0.1	0.1	-0.3	-0.1
Mean num. licks in bursts	0.2	0.3	0.8	0.9	-0.3	0.2
Cd content in liver	3.4	3.8	4.5	1.9	-1.9	-2.1
Co content in liver	0.0	0.0	0.1	0.3	0.1	0.1
Cu content in liver	0.6	0.7	1.1	-0.5	0.9	1.1
Fe content in liver	1.3	1.6	1.9	1.0	-1.4	-1.4
K content in liver	0.0	0.0	0.1	0.1	-0.1	0.3
Mg content in liver	1.2	1.2	1.6	1.3	-1.2	-0.8
Mn content in liver	0.3	0.3	0.5	-0.7	0.3	0.5
Na content in liver	0.0	0.0	0.1	-0.1	-0.2	0.0
Rb content in liver	0.3	0.4	0.4	0.6	-0.6	-0.6
Se content in liver	0.5	0.6	0.8	0.6	-0.9	-0.7
Sr content in liver	0.2	0.2	0.3	0.1	0.6	0.5
Zn content in liver	0.5	0.6	1.0	-0.1	1.0	0.8
Bone: minimum diameter	1.2	2.2	3.0	-1.2	1.5	1.7
Time in familiar zone, hab. session 1	0.7	0.7	1.3	1.1	-0.5	-0.7
Time in novel zone, hab. session 1	0.4	0.4	1.1	-1.1	0.2	0.3
Total zone transitions, hab. session 1	1.3	1.8	2.2	1.2	-1.3	-1.5
Total locomotion distance, hab. session 1	0.9	1.2	1.6	1.0	-1.0	-1.3
Locomotion velocity, hab. session 1	0.8	1.1	1.2	1.1	-0.9	-1.1
Time in familiar zone, hab. session 2	1.0	1.1	1.2	1.1	-0.9	-1.1
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.7	0.3	0.4
Total zone transitions, hab. session 2	3.7	4.7	5.6	2.4	-2.0	-2.1
Total locomotion distance, hab. session 2	1.9	2.4	3.6	1.9	-1.3	-1.4
Locomotion velocity, hab. session 2	1.3	1.7	2.7	1.7	-1.1	-1.1
Novel to familiar place preference ratio	0.2	0.3	0.7	0.9	-0.1	0.2
Novelty place preference	0.2	0.2	0.6	0.7	-0.0	0.2
Time in novel zone, NPP test	0.3	0.4	1.0	1.0	-0.3	-0.1
Total zone transitions, NPP test	2.2	3.2	3.6	1.7	-1.8	-1.9
Total locomotion distance, NPP test	3.6	4.9	6.8	2.6	-1.8	-2.2
Locomotion velocity, NPP test	2.5	3.6	5.1	2.3	-1.5	-1.8
Intraocular pressure	0.4	0.5	0.7	0.8	-0.8	-0.5
Delta distance traveled before/after self-admin	2.1	2.3	2.7	1.6	-1.3	-1.5
Delta ambulatory time before/after self-admin	2.6	3.2	3.5	1.8	-1.7	-1.9
Parametrial fat weight	0.2	0.4	1.2	1.1	0.0	0.2
Pavlov. Cond. lever latency	4.6	5.8	7.7	1.6	-2.8	-2.7
Pavlov. Cond. magazine entry latency	3.4	4.4	4.9	-2.0	2.0	2.2
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	0.0	0.8	0.7
Pavlov. Cond. index score	4.3	5.4	6.5	-1.8	2.5	2.6
Pavlov. Cond. latency score	5.0	6.4	7.9	-1.9	2.8	2.7
Pavlov. Cond. lever contacts	2.1	2.5	3.9	-0.6	2.0	1.8
Pavlov. Cond. magazine entry number	3.8	4.8	5.4	1.9	-2.3	-2.3
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.4	1.2	-1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	3.4	4.2	5.3	-1.5	2.3	2.3
Pavlov. Cond. response bias	3.5	4.3	5.2	-1.6	2.3	2.3
Pavlov. Cond. lever latency	1.4	1.9	2.2	-1.4	1.5	1.2
Pavlov. Cond. magazine entry latency	4.4	5.3	6.2	2.2	-2.2	-2.5
Pavlov. Cond. change in total contacts	2.6	4.2	4.6	1.9	-2.1	-2.1
Pavlov. Cond. index score	2.9	4.0	4.1	1.9	-2.0	-2.0
Pavlov. Cond. latency score	2.6	3.4	3.8	1.7	-1.9	-1.9
Pavlov. Cond. lever contacts	1.9	2.7	3.0	1.7	-1.7	-1.5
Pavlov. Cond. magazine entry number	3.7	4.5	5.1	-1.9	2.2	2.3
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.9	0.1	0.9
Pavlov. Cond. lever-magazine prob. diff.	3.2	4.3	4.5	2.0	-2.1	-2.1
Pavlov. Cond. response bias	3.0	4.0	4.5	2.1	-2.0	-2.0
Time in closed arm before self-admin	0.5	0.7	1.0	-0.3	1.0	0.9
Time in closed arm after self-admin	1.1	1.1	1.4	-0.9	1.2	1.1
Time in open arm before self-admin	0.1	0.1	0.4	-0.6	0.1	-0.0
Time in open arm after self-admin	1.4	1.6	2.0	1.4	-1.2	-1.1
Bone: periosteal estimation	1.0	2.0	2.3	-1.5	1.3	1.5
Bone: periosteal perimeter	7.0	12.0	13.3	-3.3	3.5	3.6
Bone: post-yield work	0.1	0.2	0.4	0.4	-0.6	-0.2
Progressive ratio test 1 active lever presses	0.2	0.3	0.5	0.7	-0.3	-0.6
Progressive ratio test 1 breakpoint	0.2	0.2	0.4	0.7	-0.2	-0.5
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.1	0.4	-0.0	0.1
Progressive ratio test 2 active lever presses	0.4	0.5	1.0	1.0	-0.0	-0.7
Progressive ratio test 2 breakpoint	0.4	0.5	0.9	1.0	-0.0	-0.7
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	0.1	0.7	-0.3
Incentive Sensitization - Responses	0.1	0.1	0.3	0.2	0.6	0.0
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	0.2	0.6	-0.0
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	0.7	-0.5	-0.6
Progressive ratio	0.6	0.9	1.7	0.5	-0.8	-1.3
Food seeking constrained by brief footshock	0.1	0.2	0.4	-0.6	0.2	-0.2
Seeking ratio, punishment vs. effort	0.2	0.3	0.4	-0.6	0.3	0.6
Retroperitoneal fat weight	0.0	0.1	0.2	-0.1	0.1	0.5
Reaction time number correct	4.3	8.4	8.8	2.8	-2.9	-3.0
Reaction time mean minus median	0.3	0.7	0.9	-0.7	1.0	0.8
Reaction time mean minus median AUC	0.6	1.6	1.8	-1.3	1.3	1.2
Reaction time num false alarms	0.2	0.3	0.4	0.6	-0.4	-0.5
Reaction time num false alarms AUC	0.3	0.5	0.7	0.8	-0.7	-0.7
Reaction time trials correct on left	4.3	8.4	8.8	2.8	-2.9	-3.0
Reaction time trials on left	4.5	8.4	8.9	2.8	-2.9	-3.0
Reaction time mean	0.0	0.0	0.1	-0.0	-0.1	-0.3
Reaction time mean AUC	0.1	0.1	0.3	0.2	-0.3	-0.5
Median of all reaction times	0.1	0.2	0.4	0.2	-0.4	-0.6
Reaction time omissions	0.5	0.7	1.5	-1.2	0.7	0.4
Reaction time false alarm rate	0.4	0.6	0.6	-0.7	0.8	0.8
Reaction time premature initiation rate	1.3	1.8	2.7	1.6	-1.3	-1.0
Reaction time premature initiations	4.6	8.2	9.6	3.1	-2.9	-2.6
Std. dev. reaction times	0.1	0.1	0.2	0.0	-0.3	-0.5
Reaction time trials completed	4.5	8.4	8.9	2.8	-2.9	-3.0
Reaction time trials AUC	4.8	9.1	9.5	3.0	-3.0	-3.1
Run reversals in cocaine runway, females	2.0	2.0	3.3	0.8	-1.4	-1.8
Run reversals in cocaine runway, males	0.5	0.5	1.3	0.2	1.1	0.6
Latency to leave start box in cocaine runway	1.1	1.3	1.4	1.2	-1.1	-1.1
Latency to leave start box in cocaine runway, F	1.7	1.9	2.0	1.4	-1.3	-1.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	0.5	-0.3	-0.2
Std. dev. time between licks in bursts	1.1	1.5	2.5	1.4	-1.6	-0.5
Total sessions with >9 infusions	0.2	0.2	0.6	0.2	-0.3	-0.8
Short access day 1 total inactive lever presses	0.5	0.6	0.7	-0.8	0.8	0.7
Short access day 10 total inactive lever presses	0.4	0.9	1.7	-0.4	0.8	1.3
Short access day 1 total infusions	0.5	0.6	1.1	0.6	-0.7	-1.1
Short access day 10 total infusions	0.2	0.2	0.3	0.3	0.6	0.4
Short access total infusions	0.2	0.2	0.5	0.4	-0.1	-0.7
Short access day 1 locomotion	0.0	0.1	0.2	0.1	0.4	-0.1
Short access day 10 total locomotion	0.1	0.2	0.5	-0.2	0.5	0.7
Short access total locomotion	0.4	0.5	0.7	-0.7	0.9	0.5
One hour access (0.3 mA shock)	0.8	0.9	1.2	1.1	-0.5	-1.1
Compulsive drug intake	0.1	0.1	0.2	0.1	-0.3	0.4
One hour access (shock baseline)	0.1	0.2	0.3	0.4	0.4	-0.5
Social response proportion	0.2	0.3	0.4	-0.1	-0.6	-0.7
Social responses	0.0	0.0	0.0	-0.1	-0.1	-0.2
Social time	0.0	0.0	0.1	0.1	-0.1	-0.3
Soleus weight	0.8	2.2	3.4	-0.6	1.7	1.9
Bone: stiffness	0.8	1.3	1.7	-1.3	1.2	0.9
Tibialis anterior weight	0.1	0.2	0.4	0.6	-0.1	-0.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.0	0.6	0.7
Time to tail flick, vehicle, after self-admin	0.6	0.8	1.4	-0.7	1.2	0.7
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.2	-0.5	0.2
Time to tail flick, test, after self-admin	1.7	1.8	3.7	-1.9	0.9	0.8
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.0	-0.1	-0.1	-0.2
Delta time to tail flick, test, before/after SA	1.0	1.0	2.2	-1.5	0.9	0.1
Tibia length	13.5	37.1	43.8	-6.6	5.9	5.7
Ambulatory time before self-admin	0.6	0.9	1.1	-0.8	1.0	1.0
Ambulatory time after self-admin	0.8	1.0	1.4	1.2	-0.9	-0.8
Bone: tissue strength	0.3	0.3	0.9	1.0	0.0	-0.1
Total heroin consumption	0.3	0.4	1.2	-1.1	0.1	0.2
Bone: trabecular number	0.0	0.0	0.0	0.1	-0.2	0.1
Bone: trabecular spacing	1.1	1.5	2.8	0.5	-1.2	-1.7
Bone: trabecular thickness	0.5	0.7	1.3	0.1	0.8	1.1
Bone: trabecular tissue density	0.2	0.4	1.0	-1.0	0.2	0.2
Water consumed over 24 hours	0.1	0.2	0.3	0.1	0.4	0.5
Number of responses in last shaping day	0.6	0.6	0.8	-0.7	0.9	0.8