Hub : Genes

Cbarp

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression Cbarp 0.23 0.14 2.7e-06 0.12 0.13 0.14 0.13 1.0e-05 3.4e-06 1.9e-06 5.1e-06
2 Brain gene expression Cbarp 0.14 0.08 1.3e-12 0.13 0.12 0.12 0.13 2.9e-12 2.5e-11 5.1e-11 5.5e-12
3 BLA alternative TSS XM_039078983.2 0.07 0.05 2.8e-03 0.05 0.02 0.03 0.02 1.9e-03 2.4e-02 1.1e-02 2.2e-02
4 BLA alternative TSS XM_039078983.2 0.06 0.04 5.5e-03 0.04 0.02 0.02 0.02 5.0e-03 3.1e-02 2.8e-02 2.6e-02
5 PL intron excision ratio chr7_10217596_10219275 0.05 0.04 1.2e-05 0.04 0.05 0.06 0.05 1.2e-05 2.4e-06 3.1e-07 6.2e-06
6 BLA gene expression Cbarp 0.08 0.06 1.5e-04 0.1 0.08 0.08 0.09 7.2e-06 5.4e-05 5.0e-05 1.1e-05
7 NAcc isoform ratio NM_001388507.1 0.04 0.03 7.2e-07 0.03 0.04 0.03 0.03 2.0e-05 4.0e-06 2.8e-05 9.8e-06
8 BLA intron excision ratio chr7_10217596_10219275 0.06 0.05 5.3e-04 0.04 0.06 0.05 0.06 2.6e-03 4.8e-04 9.9e-04 6.7e-04
9 BLA isoform ratio NM_001388507.1 0.06 0.05 4.5e-04 0.05 0.06 0.06 0.06 1.0e-03 2.5e-04 5.5e-04 4.2e-04
10 BLA mRNA stability Cbarp 0.04 0.03 5.9e-03 0.02 0.02 0 0.01 2.1e-02 2.3e-02 2.9e-01 5.3e-02
11 OFC gene expression Cbarp 0.31 0.17 7.5e-06 0.19 0.16 0.18 0.17 2.4e-05 1.1e-04 3.9e-05 5.9e-05
12 NAcc intron excision ratio chr7_10219798_10220178 0.02 0.02 4.1e-04 0.01 0.02 0.02 0.02 4.1e-03 8.9e-04 1.0e-03 1.6e-03
13 PL gene expression Cbarp 0.25 0.14 0.0e+00 0.15 0.17 0.17 0.17 3.9e-16 5.2e-18 9.4e-19 1.5e-18
14 Brain alternative polyA XM_039078984.2 0.04 0.03 1.6e-03 0.03 0.02 0.02 0.02 1.9e-03 6.8e-03 4.5e-03 6.0e-03
15 IC mRNA stability Cbarp 0.09 0.06 1.8e-03 0.06 0.04 0.05 0.04 1.7e-03 7.9e-03 3.8e-03 5.7e-03
16 Brain isoform ratio NM_001388507.1 0.04 0.03 4.6e-04 0.04 0.03 0.03 0.04 8.1e-05 5.5e-04 1.0e-03 1.2e-04
17 Brain alternative polyA XM_039078985.2 0.04 0.03 1.9e-03 0.02 0.02 0.02 0.02 2.6e-03 8.8e-03 6.0e-03 9.6e-03
18 Eye intron excision ratio chr7_10219798_10220178 0.19 0.13 6.0e-03 0.15 0.12 0.13 0.11 2.6e-03 7.6e-03 4.4e-03 8.4e-03
19 OFC isoform ratio NM_001108070.3 0.13 0.1 1.5e-03 0.13 0.13 0.13 0.13 6.7e-04 6.8e-04 6.2e-04 6.1e-04
20 RMTg isoform ratio NM_001388507.1 0.29 0.23 7.2e-03 0.11 0.01 -0.01 0.07 7.8e-04 1.2e-01 8.4e-01 6.5e-03
21 OFC intron excision ratio chr7_10217596_10219275 0.27 0.16 9.0e-04 0.04 0.03 0.09 0.06 4.0e-02 6.6e-02 3.2e-03 1.6e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density0.61.15.21.40.90.80.80.60.8-0.2-0.2-0.30.90.90.51.7-0.8-0.70.90.70.70.72.32.1
Area under the delay curve1.42.12.8-1.6-1.3-1.5-1.51.6-1.6-1.7-1.6-1.6-1.3-1.31.6-1.1-1.5-1.61.61.51.61.6-0.51.0
BMI with tail5.920.526.2-4.0-4.8-4.8-4.84.9-5.0-4.8-4.9-4.9-5.1-5.14.8-3.8-4.8-4.64.64.84.64.6-1.22.0
BMI without tail1.26.28.6-2.9-2.9-2.9-2.92.8-2.8-2.6-2.6-2.6-2.8-2.82.5-2.5-2.3-2.42.22.32.32.3-1.30.5
Body weight0.83.74.8-1.5-2.0-2.0-2.01.9-2.1-2.1-2.1-2.1-2.2-2.22.1-1.7-2.1-2.12.02.11.91.9-0.40.8
Weight adjusted by age0.20.71.8-1.3-1.2-1.2-1.20.7-0.8-0.8-0.8-0.7-0.8-0.80.6-1.1-0.5-0.60.60.50.40.4-0.7-0.4
Bone surface1.42.79.92.61.91.91.9-0.21.90.50.50.42.02.0-0.13.0-0.4-0.30.40.30.30.33.12.6
Bone volume1.32.59.12.41.91.81.8-0.21.90.30.30.22.02.00.12.9-0.6-0.40.60.50.30.33.02.7
Breakpoint value in progressive ratio session2.13.74.91.31.91.91.9-2.21.72.22.22.21.71.7-2.21.02.22.2-2.2-2.2-2.1-2.1-1.1-1.6
Number of licking bursts0.10.41.6-1.3-0.6-0.7-0.70.7-0.8-0.2-0.2-0.2-0.6-0.60.1-1.10.10.10.1-0.1-0.2-0.2-1.1-1.2
Context. condit. distance diff. score0.30.41.8-1.3-0.8-0.8-0.80.3-0.7-0.6-0.6-0.5-0.6-0.60.5-0.4-0.1-0.70.20.10.60.6-0.40.2
Locomotion velocity, session 10.91.03.01.51.21.21.2-1.21.40.80.70.71.21.2-0.61.70.40.4-0.3-0.4-0.4-0.41.50.8
Locomotion distance, session 11.31.78.83.01.41.41.4-0.51.20.60.60.51.01.0-0.32.20.4-0.1-0.1-0.30.10.12.71.8
Locomotion velocity, session 25.26.214.03.73.03.03.0-3.12.92.42.42.32.62.6-2.13.22.11.7-2.0-2.1-1.5-1.52.60.7
Locomotion distance, session 22.94.115.33.92.62.62.6-1.62.31.71.61.62.12.1-1.32.81.01.1-0.9-0.9-1.0-1.03.11.3
Locomotion velocity, session 35.56.39.11.72.52.52.5-3.02.42.82.82.82.42.4-2.91.72.92.8-2.9-2.9-2.6-2.6-0.1-1.7
Locomotion distance, session 30.00.10.3-0.6-0.2-0.3-0.3-0.2-0.1-0.0-0.00.0-0.1-0.1-0.1-0.10.20.1-0.1-0.3-0.0-0.0-0.6-0.3
Stereotopy head waving bouts, day 35.06.08.72.72.92.92.9-2.12.52.72.72.62.52.5-2.62.32.52.5-2.4-2.5-2.2-2.21.3-0.6
Stereotopy head waving duration, day 35.87.29.72.63.13.13.1-2.62.82.92.92.92.82.8-2.92.32.82.9-2.8-2.8-2.5-2.50.9-1.1
Locomotion velocity, session 70.60.62.4-0.50.30.30.3-1.61.00.60.60.71.01.0-0.60.61.20.6-0.9-1.2-0.8-0.8-0.5-0.5
Locomotion distance, session 70.50.62.7-1.7-1.1-1.1-1.10.1-0.7-0.6-0.5-0.5-0.8-0.80.4-1.10.1-0.30.2-0.10.10.1-1.5-0.8
Stereotopy head waving bouts, day 70.30.41.70.40.70.70.70.50.40.10.10.10.50.50.11.3-0.3-0.10.20.30.40.41.31.2
Stereotopy head waving duration, day 70.70.93.21.11.31.31.3-0.11.10.70.60.61.21.2-0.51.80.10.4-0.2-0.1-0.2-0.21.61.1
Locomotion velocity, session 81.41.75.02.21.51.51.5-1.71.50.90.90.91.51.5-0.71.90.90.4-0.5-0.8-0.3-0.32.21.3
Locomotion distance, session 80.30.51.31.00.80.80.8-0.70.70.60.60.60.70.7-0.51.10.70.2-0.5-0.7-0.2-0.21.20.6
Degree of sensitization distance0.40.40.7-0.6-0.8-0.8-0.80.4-0.6-0.8-0.7-0.7-0.6-0.60.8-0.5-0.4-0.90.50.50.70.7-0.10.4
Degree of sensitization stereotypy1.51.73.1-1.0-0.9-0.9-0.91.8-0.9-1.3-1.3-1.4-0.9-0.91.40.1-1.7-1.51.61.71.61.60.71.6
Conditioned locomotion1.61.94.2-1.4-1.7-1.7-1.70.7-1.7-1.3-1.3-1.3-1.7-1.71.1-2.0-0.9-0.91.01.00.90.9-1.6-0.6
Cocaine response after cond. corrected4.66.914.3-3.8-3.2-3.2-3.22.3-3.1-2.7-2.7-2.6-3.0-3.02.4-3.2-2.0-2.21.82.02.12.1-2.3-0.1
Cocaine response after cond. not corrected5.17.416.1-4.0-3.3-3.3-3.32.5-3.2-2.7-2.7-2.7-3.1-3.12.5-3.3-2.0-2.21.82.02.22.2-2.5-0.2
Cocaine response before conditioning0.50.60.90.30.80.80.8-0.71.00.80.80.81.01.0-0.81.00.70.7-0.7-0.8-0.7-0.7-0.1-0.2
Saline control response0.20.31.6-0.6-0.6-0.6-0.60.4-0.7-0.4-0.4-0.4-0.7-0.70.4-0.8-0.4-0.30.40.50.20.2-1.3-0.4
Bone: connectivity density0.50.73.10.80.30.20.20.90.2-0.5-0.6-0.60.20.20.71.0-0.9-0.91.00.90.90.91.71.8
Bone: cortical apparent density0.71.11.8-0.5-1.0-1.0-1.01.1-0.9-1.2-1.2-1.2-0.9-0.91.2-0.8-1.4-1.01.31.31.11.1-0.30.7
Bone: cortical area0.40.62.1-0.2-0.2-0.2-0.20.60.0-0.8-0.8-0.80.10.10.90.6-1.1-1.11.11.11.01.00.91.4
Bone: cortical porosity0.30.41.40.90.70.70.7-0.40.80.30.30.30.80.8-0.21.00.20.1-0.1-0.2-0.2-0.21.20.5
Bone: cortical porosity0.40.52.71.00.70.70.7-0.10.70.10.10.00.70.70.11.2-0.2-0.40.30.20.20.21.61.2
Bone: cortical thickness0.91.42.7-0.4-0.8-0.8-0.81.4-0.8-1.4-1.4-1.4-0.7-0.71.5-0.1-1.6-1.51.71.61.41.40.51.4
Bone: cortical thickness0.30.32.0-1.4-0.4-0.5-0.50.0-0.3-0.00.00.0-0.2-0.2-0.1-0.80.20.4-0.2-0.2-0.4-0.4-1.3-1.1
Bone: cortical tissue density0.50.71.3-0.4-0.8-0.8-0.80.9-0.7-1.0-1.0-1.0-0.7-0.71.0-0.7-1.2-0.81.11.10.90.9-0.30.6
Condit. Reinf. active minus inactive responses4.24.78.42.02.22.22.2-2.92.22.42.42.42.12.1-2.41.52.32.4-2.5-2.4-2.1-2.10.3-1.1
Condit. Reinf. active-inactive response ratio1.92.04.10.31.11.01.0-2.01.21.61.61.61.11.1-1.70.41.61.7-1.9-1.7-1.6-1.6-0.7-1.5
Condit. Reinf. active responses4.25.311.33.42.72.72.7-2.72.52.42.42.32.42.4-2.22.32.02.1-2.2-2.1-1.9-1.91.6-0.2
Condit. Reinf. inactive responses1.52.09.13.01.61.61.6-1.11.61.11.11.01.51.5-0.91.90.70.4-0.6-0.6-0.6-0.62.20.9
Incentive salience index mean2.53.36.32.52.12.02.0-2.21.91.91.91.91.81.8-1.81.81.61.6-1.8-1.7-1.4-1.41.2-0.1
Condit. Reinf. lever presses0.81.16.62.61.11.11.1-0.10.80.30.30.20.80.8-0.01.6-0.3-0.30.20.40.30.32.41.7
Condit. Reinf. active minus inactive responses1.42.13.70.11.11.21.2-1.61.21.61.61.61.31.3-1.70.31.51.9-1.4-1.5-1.9-1.9-1.1-1.9
Condit. Reinf. active-inactive response ratio0.20.32.1-0.6-0.3-0.3-0.30.4-0.40.10.10.1-0.4-0.4-0.3-1.00.00.50.00.0-0.6-0.6-1.0-1.4
Condit. Reinf. active responses1.72.44.10.41.51.51.5-2.01.61.61.61.71.71.7-1.70.81.51.9-1.3-1.5-1.9-1.9-0.9-1.4
Condit. Reinf. inactive responses1.01.54.40.31.21.21.2-2.11.41.11.11.21.51.5-1.20.91.31.2-1.1-1.3-1.2-1.2-0.8-0.5
Condit. Reinf. lever presses1.42.03.10.21.11.11.1-1.61.21.51.51.61.31.3-1.60.61.51.7-1.6-1.5-1.8-1.8-1.2-1.6
Condit. Reinf. lever reinforcers received1.21.72.9-0.21.01.01.0-1.71.21.31.31.41.31.3-1.40.41.31.7-1.1-1.3-1.7-1.7-1.4-1.6
Conditioned reinforcement - actives0.31.12.7-0.50.50.50.5-0.60.81.11.11.10.80.8-1.20.01.41.3-1.4-1.4-1.5-1.5-0.1-1.7
Conditioned reinforcement - inactives0.10.10.9-0.9-0.5-0.5-0.50.5-0.4-0.2-0.2-0.1-0.5-0.50.1-0.60.00.1-0.0-0.00.00.0-0.3-0.5
Conditioned locomotion5.58.19.82.33.03.03.0-3.03.13.13.13.13.03.0-3.12.32.93.0-2.9-2.9-3.1-3.10.5-1.7
Patch foraging indifference point 0 sec0.10.30.7-0.3-0.3-0.3-0.30.7-0.4-0.6-0.6-0.6-0.2-0.20.6-0.0-0.7-0.70.80.80.50.50.30.6
Patch foraging indifference point AUC0.40.91.50.80.90.90.9-1.00.91.11.11.00.80.8-1.10.50.91.0-1.0-0.9-1.2-1.20.1-1.0
Delay disc. indifference point, 0s delay6.47.211.2-0.7-1.8-1.9-1.93.3-2.1-2.9-2.9-3.0-2.1-2.13.1-0.5-3.3-3.33.33.33.33.32.13.4
Delay disc. indifference point, 16s delay0.10.10.3-0.5-0.3-0.2-0.20.4-0.4-0.4-0.4-0.4-0.2-0.20.4-0.3-0.4-0.30.40.40.40.4-0.40.4
Delay disc. indifference point, 2s delay5.25.88.2-1.6-2.2-2.3-2.32.4-2.2-2.7-2.7-2.7-2.2-2.22.8-1.1-2.7-2.82.82.72.92.90.02.3
Delay disc. indifference point, 24s delay0.50.81.7-1.3-1.1-1.1-1.11.2-0.9-0.9-0.9-0.9-0.7-0.70.9-1.0-0.9-0.80.80.90.60.6-0.8-0.0
Delay disc. indifference point, 4s delay1.01.12.6-1.1-0.8-0.8-0.81.6-1.1-1.1-1.1-1.1-0.7-0.71.2-0.4-1.1-1.11.11.11.31.3-0.01.3
Delay disc. indifference point, 8s delay0.91.43.2-1.8-1.2-1.4-1.40.9-1.4-1.4-1.3-1.3-1.2-1.21.2-1.4-0.9-1.21.10.91.01.0-0.70.1
Indifference point function ln k0.10.31.8-1.3-0.8-0.7-0.70.6-0.6-0.5-0.5-0.5-0.3-0.30.4-0.6-0.3-0.30.30.30.40.4-0.80.0
Indifference point function log k0.10.31.8-1.3-0.8-0.7-0.70.6-0.6-0.5-0.5-0.5-0.3-0.30.4-0.6-0.3-0.30.30.30.40.4-0.80.0
Patch foraging total patch changes 0 sec0.10.20.4-0.3-0.3-0.3-0.30.6-0.4-0.5-0.5-0.5-0.2-0.20.5-0.0-0.5-0.60.70.60.50.50.20.5
Patch foraging total patch changes 12 sec0.50.61.3-0.6-1.0-1.0-1.01.0-1.0-0.7-0.7-0.8-1.1-1.10.7-0.9-0.6-0.70.60.60.50.5-0.4-0.3
Patch foraging total patch changes 18 sec0.41.11.41.01.21.21.2-1.11.21.11.11.11.11.1-1.11.00.90.9-1.0-0.9-1.1-1.10.3-0.5
Patch foraging total patch changes 24 sec0.00.10.20.50.50.50.5-0.40.30.30.30.30.30.3-0.20.40.00.1-0.1-0.0-0.3-0.3-0.1-0.0
Patch foraging total patch changes 6 sec0.20.41.01.00.90.90.9-0.40.70.50.50.50.70.7-0.40.70.30.3-0.2-0.2-0.5-0.51.00.1
Patch foraging time to switch 0 sec0.41.75.71.2-0.3-0.4-0.41.2-0.6-1.1-1.1-1.2-0.7-0.71.40.7-1.3-1.71.41.41.71.72.12.4
Patch foraging water rate 0 sec0.31.04.9-2.2-1.1-1.0-1.0-0.0-0.7-0.2-0.2-0.1-0.6-0.6-0.1-1.70.50.3-0.3-0.5-0.4-0.4-2.1-1.8
Patch foraging water rate 12 sec0.72.98.8-3.0-2.1-2.1-2.11.5-2.0-1.4-1.4-1.3-1.8-1.81.1-2.6-1.0-0.81.01.00.70.7-2.3-1.1
Patch foraging water rate 18 sec1.12.312.9-2.8-1.4-1.3-1.3-0.2-1.3-0.00.00.1-1.0-1.0-0.4-2.50.90.9-0.8-0.8-0.9-0.9-3.6-2.9
Patch foraging water rate 24 sec1.92.78.8-2.9-2.1-2.0-2.00.6-1.9-0.9-0.8-0.8-1.8-1.80.5-3.0-0.0-0.00.10.00.00.0-2.9-2.2
Patch foraging water rate 6 sec0.71.16.3-1.7-0.5-0.5-0.5-0.6-0.20.40.40.5-0.2-0.2-0.6-1.30.71.0-0.9-0.9-1.1-1.1-2.5-2.2
Seeking ratio, delayed vs. immediate footshock3.24.69.12.02.42.42.4-3.02.42.32.32.32.32.3-2.21.82.12.1-2.1-2.1-2.0-2.0-0.3-0.7
Distance traveled before self-admin0.10.20.40.2-0.3-0.3-0.30.0-0.1-0.5-0.5-0.5-0.1-0.10.50.0-0.6-0.60.60.60.40.40.00.7
Distance traveled after self-admin0.00.00.30.30.10.10.1-0.50.20.00.00.00.20.2-0.00.1-0.0-0.00.00.0-0.1-0.1-0.30.1
Extensor digitorum longus weight4.116.321.0-4.5-4.6-4.6-4.63.8-4.6-4.3-4.3-4.3-4.6-4.64.1-4.1-3.7-3.93.73.83.93.9-2.11.1
Bone: elastic displacement0.10.20.30.30.50.50.5-0.20.50.30.30.30.50.5-0.30.30.20.5-0.3-0.2-0.4-0.40.4-0.1
Bone: elastic work0.30.31.0-1.0-0.5-0.5-0.50.3-0.2-0.7-0.7-0.7-0.1-0.10.7-0.1-0.7-0.80.60.70.70.70.10.7
Bone: endosteal estimation0.10.30.6-0.6-0.4-0.4-0.40.0-0.3-0.6-0.6-0.5-0.3-0.30.6-0.1-0.5-0.70.40.50.80.80.30.8
Bone: endosteal perimeter0.30.71.70.51.01.01.0-0.81.10.80.80.81.21.2-0.71.30.60.6-0.7-0.7-0.5-0.50.80.3
Epididymis fat weight0.10.52.4-1.3-0.6-0.6-0.6-0.1-0.70.00.00.0-0.9-0.9-0.2-1.00.40.3-0.4-0.3-0.1-0.1-1.6-1.3
Delta time in closed arm before/after self-admin2.12.06.3-2.3-1.8-1.8-1.81.0-1.6-0.9-0.9-0.8-1.6-1.60.6-2.4-0.4-0.30.40.40.10.1-2.5-1.7
Delta time in open arm before/after self-admin0.40.40.7-0.4-0.6-0.7-0.70.3-0.6-0.7-0.7-0.7-0.7-0.70.7-0.5-0.7-0.70.70.70.80.80.10.5
Diff in mean of infusions in LGA sessions1.11.92.81.31.51.51.5-1.71.31.61.61.51.31.3-1.51.01.61.5-1.5-1.6-1.3-1.3-0.3-0.7
Delay discount exponential model param1.31.82.71.61.31.41.4-1.41.41.51.51.51.21.2-1.51.11.31.4-1.4-1.3-1.4-1.40.7-0.8
Extinction: sum of active levers before priming0.50.71.50.30.60.60.6-0.70.41.01.01.00.40.4-1.00.01.11.0-1.1-1.1-1.0-1.0-1.0-1.2
Active lever presses in extinction session 62.02.02.81.51.61.61.6-1.51.61.51.51.51.71.7-1.41.41.21.3-1.3-1.2-1.5-1.50.5-0.4
Bone: final force1.01.63.1-0.9-0.8-0.9-0.90.9-0.7-1.6-1.5-1.5-0.6-0.61.6-0.1-1.6-1.81.61.61.61.60.51.7
Bone: final moment0.81.32.5-0.8-0.7-0.7-0.70.7-0.6-1.4-1.4-1.4-0.5-0.51.5-0.1-1.5-1.61.41.51.51.50.51.6
Food consumed during 24 hour testing period0.40.71.4-1.2-1.0-1.0-1.00.7-1.0-1.0-0.9-0.9-0.8-0.80.9-1.0-0.6-0.80.80.50.80.8-0.80.2
Glucose2.64.15.3-2.2-2.2-2.1-2.12.1-2.0-2.2-2.2-2.2-2.0-2.02.2-1.7-2.2-2.12.32.32.02.0-0.70.8
Heart weight0.50.92.9-1.10.20.20.2-0.70.10.90.90.90.20.2-1.0-0.41.01.2-1.3-1.0-1.1-1.1-1.5-1.7
Delay discount hyperbolic model param2.33.04.01.91.61.81.8-1.91.82.02.02.01.51.5-2.01.21.81.9-1.9-1.8-1.9-1.90.6-1.3
Intermittent access intake day 1-15 change1.05.28.31.11.91.91.9-2.42.02.52.62.62.12.1-2.61.02.72.7-2.7-2.7-2.9-2.9-0.6-2.4
Intermittent access intake escalation0.94.67.21.11.81.81.8-2.31.92.42.42.42.02.0-2.50.92.52.5-2.5-2.5-2.7-2.7-0.5-2.2
Intermittent access intake escalation 22.64.36.31.11.81.81.8-2.52.02.32.32.32.02.0-2.31.12.32.4-2.3-2.3-2.5-2.5-0.6-2.0
Intermitt. access day 1 inactive lever presses0.00.62.5-1.5-0.6-0.6-0.6-0.4-0.40.10.20.2-0.4-0.4-0.3-1.10.60.5-0.6-0.6-0.7-0.7-1.6-1.6
Intermitt. access day 15 inactive lever presses0.10.40.60.60.70.70.7-0.70.80.70.70.70.70.7-0.70.60.70.7-0.7-0.7-0.6-0.60.6-0.2
Intermitt. access escalation Index0.30.92.50.5-0.3-0.3-0.31.0-0.3-0.9-0.9-0.9-0.3-0.31.00.3-1.2-1.21.21.21.11.11.51.6
Intermittent access day 1 total infusions0.10.31.6-1.3-0.2-0.2-0.20.3-0.10.30.30.3-0.0-0.0-0.4-0.50.60.5-0.6-0.6-0.5-0.5-0.7-0.9
Intermittent access day 15 total infusions1.12.84.30.21.31.31.3-1.41.41.91.91.91.61.6-2.00.72.02.0-2.0-2.0-2.1-2.1-0.4-1.8
Intermittent access terminal intake (last 3 days)1.01.82.80.01.01.01.0-0.91.21.51.51.51.31.3-1.60.81.71.6-1.6-1.7-1.7-1.7-0.1-1.4
Intermittent access total infusions0.70.81.4-0.40.60.60.6-0.20.61.01.01.00.80.8-1.10.31.21.1-1.2-1.2-1.2-1.20.0-1.1
Intermittent access day 1 locomotion0.81.53.3-0.50.70.70.7-1.10.71.31.31.40.70.7-1.5-0.21.71.6-1.7-1.7-1.5-1.5-1.1-1.8
Intermittent access day 15 total locomotion1.14.36.51.01.81.81.8-2.21.82.32.42.41.71.7-2.40.82.52.6-2.5-2.5-2.5-2.5-0.0-2.1
Intermittent access total locomotion1.82.23.50.41.21.21.2-1.41.21.71.71.71.21.2-1.80.41.91.8-1.9-1.9-1.8-1.8-0.5-1.7
Intermittent access standard deviation1.26.37.81.22.42.42.4-2.82.82.82.82.82.72.7-2.81.92.82.7-2.8-2.8-2.8-2.80.6-1.7
Left kidney weight0.10.52.3-1.4-0.8-0.7-0.7-1.0-0.5-0.2-0.2-0.1-0.6-0.6-0.0-1.20.50.1-0.4-0.6-0.1-0.1-1.5-1.0
Right kidney weight0.32.07.8-0.60.60.60.6-2.81.01.31.31.30.80.8-1.5-0.41.71.6-1.9-1.8-1.6-1.6-1.6-2.0
Cocaine induced anxiety0.82.25.32.31.91.91.9-1.51.91.41.31.31.71.7-1.22.10.90.9-0.9-0.9-1.0-1.01.50.5
Post-drug Anxiety1.92.15.32.31.91.91.9-1.71.81.41.31.31.51.5-1.12.10.90.9-0.9-0.9-0.7-0.71.10.7
Baseline Anxiety0.10.11.0-0.30.10.10.1-0.60.20.20.30.30.20.2-0.3-0.00.30.3-0.3-0.3-0.2-0.2-1.0-0.3
Tail length2.111.517.81.93.13.13.1-4.23.53.63.73.73.53.5-3.72.04.13.6-3.9-4.0-3.8-3.8-0.3-2.6
Length with tail1.77.512.81.82.62.62.6-3.62.72.93.03.02.72.7-3.01.73.32.9-3.1-3.1-3.0-3.0-0.1-2.0
Length without tail0.00.00.2-0.2-0.2-0.1-0.1-0.4-0.1-0.1-0.1-0.1-0.2-0.20.1-0.2-0.1-0.10.10.20.10.1-0.2-0.1
Times rat made contact with spout0.40.41.7-1.0-0.8-0.8-0.8-0.3-0.8-0.5-0.5-0.5-0.7-0.70.4-1.3-0.1-0.30.3-0.00.20.2-1.2-0.5
Lifetime Intake0.30.40.9-0.60.30.30.30.00.40.70.70.70.50.5-0.80.10.90.8-0.9-0.9-0.8-0.8-0.1-0.9
Liver weight, left0.91.62.3-1.4-1.3-1.3-1.31.5-1.5-1.3-1.3-1.3-1.4-1.41.2-1.3-1.3-1.11.11.21.31.3-0.60.4
Liver weight, right0.71.23.5-1.9-1.4-1.4-1.40.2-1.1-1.1-1.1-1.1-1.2-1.21.0-1.4-0.7-0.90.60.60.90.9-1.1-0.1
Locomotor activity3.24.98.12.82.72.82.8-2.02.72.22.22.12.82.8-2.02.61.71.8-1.7-1.7-2.0-2.01.1-0.1
Locomotor testing distance1.33.15.22.32.22.32.3-1.52.21.71.71.72.32.3-1.62.21.21.4-1.3-1.2-1.6-1.60.6-0.0
Locomotor testing rearing0.00.11.6-0.4-0.1-0.1-0.10.2-0.10.10.10.10.10.1-0.2-0.4-0.10.3-0.1-0.0-0.4-0.4-1.3-0.7
Locomotion in novel chamber0.70.91.70.81.01.01.0-1.10.81.01.01.00.80.8-1.10.11.01.1-1.0-1.0-1.3-1.3-0.3-1.1
Locomotion in novel chamber post-restriction0.51.72.8-0.01.01.01.0-1.31.11.31.31.41.31.3-1.40.61.61.4-1.5-1.7-1.5-1.5-1.4-1.1
Fecal boli incidents, locomotor time 10.61.52.9-0.4-1.3-1.2-1.20.3-1.1-1.4-1.4-1.4-1.7-1.71.4-1.1-1.1-1.51.41.11.31.3-0.20.6
Change in fecal boli incidents, locomotor task0.20.21.1-0.10.20.20.2-0.20.70.30.30.41.11.1-0.30.90.30.3-0.2-0.3-0.4-0.40.30.3
Time >=10cm from walls, locomotor time 10.50.62.50.8-0.1-0.1-0.10.30.1-0.8-0.7-0.80.00.00.90.5-1.1-1.11.11.10.60.61.61.3
Bouts of movement, locomotor time 10.30.41.40.30.30.40.4-1.20.50.60.60.60.50.5-0.60.10.90.6-0.7-0.9-0.7-0.70.1-0.6
Total resting periods, locomotor time 10.40.51.80.50.40.50.5-1.30.60.70.70.70.70.7-0.70.30.90.7-0.8-0.9-0.7-0.70.0-0.5
Rest time, locomotor task time 10.30.51.71.20.60.80.8-1.30.70.60.60.60.60.6-0.60.70.90.5-0.7-0.9-0.4-0.40.50.1
Distance moved, locomotor task time 10.41.03.0-0.1-0.5-0.5-0.51.7-0.5-1.0-1.0-1.0-0.1-0.11.10.4-1.4-1.21.31.41.01.01.41.5
Vertical activity count, locomotor time 10.10.63.2-1.8-0.8-0.9-0.91.0-0.7-0.7-0.7-0.7-0.4-0.40.6-0.8-0.8-0.50.70.80.30.3-0.8-0.2
Time >=10cm from walls, locomotor time 20.61.62.2-1.5-1.4-1.5-1.50.9-1.3-1.5-1.4-1.4-1.3-1.31.4-1.3-1.2-1.41.31.20.90.9-0.90.1
Bouts of movement, locomotor time 20.31.03.92.01.31.21.2-1.11.20.70.70.70.80.8-0.61.30.40.5-0.5-0.4-0.3-0.32.00.7
Total resting periods, locomotor time 20.31.04.32.01.31.21.2-0.91.10.70.70.70.90.9-0.51.30.40.4-0.4-0.4-0.2-0.22.10.8
Rest time, locomotor task time 20.61.01.91.41.21.21.2-1.11.20.90.90.91.21.2-0.81.20.80.7-0.8-0.8-0.8-0.80.90.1
Distance moved, locomotor task time 20.60.81.9-1.0-1.0-1.1-1.11.4-1.2-0.9-0.9-0.9-1.1-1.10.9-0.9-0.8-0.80.70.80.80.8-0.10.1
Vertical activity count, locomotor time 20.41.03.0-1.7-1.3-1.3-1.30.8-1.2-0.9-0.9-0.9-1.3-1.30.8-1.4-0.4-0.60.60.40.60.6-1.1-0.5
Light reinforcement 12.210.214.13.83.63.63.6-3.13.63.53.53.43.43.4-3.33.32.93.0-3.1-2.9-3.1-3.11.1-1.0
Light reinforcement 21.22.73.92.01.81.81.8-1.41.91.81.81.81.81.8-1.71.91.51.6-1.5-1.3-1.5-1.50.7-0.4
Bone: marrow area0.10.30.6-0.6-0.4-0.4-0.40.0-0.3-0.6-0.6-0.5-0.3-0.30.6-0.1-0.5-0.70.40.50.80.80.20.8
Bone: maximum diameter1.01.94.11.41.71.71.7-1.41.91.31.31.31.91.9-1.22.01.01.0-1.0-1.0-1.0-1.01.10.4
Bone: maximum force0.91.83.0-1.5-1.1-1.1-1.11.0-0.9-1.6-1.6-1.6-0.8-0.81.6-0.4-1.6-1.71.51.61.61.60.21.5
Bone: maximum moment0.81.52.5-1.4-1.0-1.0-1.00.8-0.8-1.5-1.5-1.4-0.7-0.71.5-0.4-1.5-1.61.41.41.51.50.21.4
Mean time between licks in bursts0.95.16.72.02.42.32.3-1.92.22.62.62.62.32.3-2.61.42.32.6-2.4-2.3-2.6-2.60.3-1.7
Mean num. licks in bursts0.00.10.60.3-0.0-0.0-0.0-0.80.2-0.1-0.2-0.10.00.00.20.0-0.1-0.20.1-0.00.30.30.10.6
Cd content in liver0.20.20.80.90.60.60.6-0.60.60.40.40.40.50.5-0.40.40.20.4-0.0-0.2-0.4-0.40.2-0.0
Co content in liver1.31.52.30.81.21.21.2-1.11.21.41.41.41.21.2-1.40.71.21.5-1.2-1.3-1.5-1.5-0.2-1.2
Cu content in liver0.50.62.31.41.01.01.0-0.61.00.50.50.50.90.9-0.31.30.30.2-0.1-0.2-0.2-0.21.50.8
Fe content in liver0.10.20.60.20.20.20.2-0.10.10.40.50.50.10.1-0.50.10.80.5-0.5-0.6-0.5-0.50.0-0.6
K content in liver0.40.41.51.20.70.70.7-0.30.60.20.20.10.50.5-0.01.0-0.2-0.10.10.20.10.11.20.9
Mg content in liver0.40.41.11.10.80.80.8-0.60.80.60.50.50.70.7-0.50.90.30.5-0.4-0.2-0.4-0.40.70.2
Mn content in liver2.52.86.32.42.02.02.0-1.62.21.31.31.32.22.2-1.12.51.10.8-0.9-1.0-0.8-0.82.31.1
Na content in liver0.80.92.70.7-0.2-0.2-0.21.0-0.4-0.9-0.9-0.9-0.5-0.51.00.5-1.1-1.21.21.11.21.21.61.6
Rb content in liver0.40.51.81.10.70.70.7-0.30.90.20.10.10.80.80.01.3-0.2-0.20.30.30.20.21.21.2
Se content in liver0.20.30.80.50.40.40.4-0.30.40.60.60.60.40.4-0.60.40.90.5-0.7-0.8-0.5-0.50.3-0.3
Sr content in liver0.10.10.3-0.4-0.3-0.3-0.30.1-0.3-0.1-0.1-0.1-0.3-0.30.0-0.50.00.0-0.0-0.0-0.0-0.0-0.6-0.4
Zn content in liver3.03.57.70.31.21.21.2-2.21.22.02.02.01.11.1-2.2-0.22.12.4-2.4-2.1-2.4-2.4-1.5-2.8
Bone: minimum diameter0.10.10.5-0.10.20.20.2-0.20.3-0.1-0.1-0.10.40.40.20.6-0.1-0.30.10.10.30.30.50.7
Time in familiar zone, hab. session 11.82.03.70.11.21.21.2-1.81.21.51.51.51.21.2-1.60.51.91.7-1.8-1.9-1.5-1.5-0.8-1.4
Time in novel zone, hab. session 11.01.12.5-0.3-0.7-0.7-0.71.2-0.4-1.1-1.1-1.1-0.5-0.51.20.3-1.5-1.31.41.51.21.21.01.6
Total zone transitions, hab. session 11.62.27.52.71.91.91.9-1.11.71.21.21.11.61.6-1.02.20.70.8-0.7-0.8-0.7-0.72.21.0
Total locomotion distance, hab. session 12.43.49.33.12.32.32.3-1.62.21.41.41.32.12.1-1.13.00.90.8-0.8-1.0-0.7-0.72.81.5
Locomotion velocity, hab. session 12.84.012.93.62.52.62.6-1.92.31.71.71.62.12.1-1.42.91.21.2-1.1-1.3-1.0-1.02.71.1
Time in familiar zone, hab. session 24.95.68.90.72.02.02.0-2.62.02.72.72.72.02.0-2.80.92.82.8-3.0-2.8-2.8-2.8-1.1-2.5
Time in novel zone, hab. session 23.74.06.7-0.7-1.6-1.7-1.71.8-1.6-2.3-2.3-2.3-1.6-1.62.4-0.9-2.4-2.42.62.42.42.40.92.3
Total zone transitions, hab. session 21.31.79.63.00.90.90.90.10.6-0.2-0.2-0.30.30.30.51.5-0.8-0.80.90.90.90.93.12.4
Total locomotion distance, hab. session 22.12.811.93.42.12.22.2-1.71.81.41.41.31.51.5-1.12.11.01.0-0.9-0.9-0.7-0.72.40.9
Locomotion velocity, hab. session 22.53.315.74.02.32.32.3-1.71.91.41.41.31.61.6-1.12.40.90.9-0.8-0.8-0.6-0.62.91.3
Novel to familiar place preference ratio3.03.96.4-0.6-1.6-1.5-1.52.3-1.4-2.2-2.2-2.2-1.4-1.42.3-0.4-2.5-2.52.52.52.42.41.42.5
Novelty place preference1.92.44.5-0.3-1.1-1.1-1.11.7-1.0-1.7-1.7-1.7-1.0-1.01.8-0.1-2.0-2.01.91.91.91.91.32.1
Time in novel zone, NPP test2.22.74.5-0.6-1.3-1.3-1.31.8-1.1-1.8-1.8-1.8-1.2-1.21.9-0.3-2.0-2.12.01.92.02.01.12.1
Total zone transitions, NPP test0.71.06.22.51.01.01.00.10.60.20.10.00.30.30.11.4-0.4-0.20.40.50.40.42.31.5
Total locomotion distance, NPP test0.70.95.22.31.00.90.9-0.30.70.10.10.00.40.40.11.5-0.4-0.30.30.30.50.52.21.6
Locomotion velocity, NPP test0.81.27.02.61.21.21.2-0.71.00.40.40.30.70.7-0.21.7-0.10.00.10.10.20.22.21.4
Intraocular pressure0.50.84.6-1.3-0.7-0.7-0.7-0.3-0.9-0.1-0.1-0.1-0.9-0.9-0.1-1.80.30.3-0.4-0.2-0.4-0.4-2.1-1.7
Delta distance traveled before/after self-admin0.40.40.70.30.60.50.5-0.80.50.70.70.70.50.5-0.70.30.80.7-0.7-0.8-0.7-0.7-0.6-0.6
Delta ambulatory time before/after self-admin0.20.40.70.40.60.60.6-0.80.60.70.70.70.60.6-0.70.50.80.6-0.7-0.8-0.6-0.6-0.1-0.4
Parametrial fat weight0.00.10.50.50.20.20.2-0.30.10.00.00.00.10.10.00.3-0.1-0.20.10.00.10.10.70.5
Pavlov. Cond. lever latency0.50.73.5-1.9-0.9-0.9-0.90.5-0.5-0.2-0.2-0.1-0.5-0.5-0.0-1.2-0.20.1-0.00.1-0.3-0.3-1.7-1.4
Pavlov. Cond. magazine entry latency3.14.06.22.32.02.02.0-2.41.72.22.22.21.71.7-2.21.32.52.1-2.3-2.4-2.0-2.00.4-1.1
Pavlov. Cond. change in total contacts0.10.10.90.90.40.30.3-0.50.20.30.30.30.20.2-0.30.40.50.2-0.4-0.5-0.2-0.20.40.1
Pavlov. Cond. index score0.81.03.31.81.21.11.1-1.30.80.90.90.90.80.8-0.81.01.20.7-0.9-1.1-0.5-0.51.00.3
Pavlov. Cond. latency score0.91.14.32.11.31.31.3-1.20.90.90.90.90.90.9-0.71.41.10.6-0.8-1.0-0.4-0.41.40.7
Pavlov. Cond. lever contacts0.40.53.01.70.80.70.7-0.40.40.10.10.10.40.40.01.00.2-0.10.0-0.20.30.31.51.2
Pavlov. Cond. magazine entry number0.91.22.2-1.4-1.0-1.0-1.01.5-0.8-1.2-1.2-1.2-0.8-0.81.2-0.5-1.5-1.11.31.41.01.0-0.10.6
Pavlov. Cond. intertrial magazine entries0.20.31.4-0.80.00.00.0-0.30.00.30.30.30.00.0-0.4-0.50.30.6-0.4-0.3-0.6-0.6-1.0-1.2
Pavlov. Cond. lever-magazine prob. diff.0.91.13.31.81.21.21.2-1.40.91.01.01.00.90.9-0.91.01.30.8-1.1-1.2-0.6-0.60.90.1
Pavlov. Cond. response bias1.01.22.51.51.11.11.1-1.60.91.21.21.20.80.8-1.20.61.51.1-1.3-1.4-1.0-1.00.2-0.5
Pavlov. Cond. lever latency0.60.81.8-0.2-0.7-0.7-0.71.4-1.1-0.8-0.9-0.9-1.2-1.20.9-0.7-0.8-0.90.70.81.11.10.80.8
Pavlov. Cond. magazine entry latency0.30.40.80.00.50.40.4-0.70.80.70.70.70.80.8-0.70.50.80.6-0.9-0.8-0.7-0.7-0.1-0.5
Pavlov. Cond. change in total contacts0.20.61.10.00.60.50.5-0.70.80.70.70.80.90.9-0.80.20.60.9-0.7-0.6-1.0-1.0-0.8-1.0
Pavlov. Cond. index score0.40.71.2-0.10.60.50.5-1.10.90.80.80.81.01.0-0.80.40.90.9-0.9-0.8-1.0-1.0-0.7-0.9
Pavlov. Cond. latency score0.40.71.30.10.70.60.6-1.01.10.80.80.81.11.1-0.80.60.80.8-0.8-0.8-1.0-1.0-0.4-0.7
Pavlov. Cond. lever contacts0.40.61.3-0.20.40.40.4-1.10.80.70.70.70.90.9-0.80.30.80.9-0.7-0.7-1.0-1.0-1.2-1.0
Pavlov. Cond. magazine entry number0.60.71.2-0.1-0.7-0.6-0.60.9-1.0-0.9-0.9-0.9-1.1-1.10.9-0.8-1.0-0.91.01.00.90.90.20.6
Pavlov. Cond. intertrial magazine entries0.30.61.9-1.4-0.8-0.8-0.8-0.0-0.9-0.7-0.7-0.7-0.9-0.90.6-1.1-0.6-0.40.70.60.50.5-1.4-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.71.30.10.70.60.6-1.11.10.80.80.91.11.1-0.90.70.90.9-0.9-0.9-1.0-1.0-0.5-0.7
Pavlov. Cond. response bias1.21.73.30.10.90.90.9-1.81.31.31.31.41.41.4-1.40.51.41.5-1.4-1.4-1.6-1.6-1.3-1.5
Time in closed arm before self-admin0.30.52.30.8-0.00.00.00.2-0.1-0.6-0.6-0.6-0.2-0.20.70.6-0.7-0.90.80.71.01.00.91.5
Time in closed arm after self-admin0.30.32.6-0.20.10.10.1-0.60.00.40.40.40.00.0-0.5-0.40.50.5-0.5-0.5-0.6-0.6-1.6-0.9
Time in open arm before self-admin0.10.10.50.20.30.30.30.40.40.30.30.30.50.5-0.30.40.20.2-0.2-0.2-0.4-0.40.7-0.1
Time in open arm after self-admin0.91.01.4-0.9-1.0-1.0-1.01.2-1.0-1.1-1.1-1.1-1.0-1.01.1-0.8-1.1-1.01.11.11.11.10.70.6
Bone: periosteal estimation0.20.52.1-0.2-0.0-0.1-0.10.20.1-0.6-0.6-0.60.10.10.70.6-0.8-0.90.80.80.90.90.91.4
Bone: periosteal perimeter0.20.51.80.50.90.80.8-0.61.00.30.30.31.11.1-0.21.30.10.0-0.1-0.1-0.1-0.11.00.8
Bone: post-yield work0.40.71.0-1.0-1.0-1.0-1.00.5-0.9-1.0-1.0-1.0-0.9-0.91.0-0.9-0.7-0.90.70.70.90.9-0.40.3
Progressive ratio test 1 active lever presses0.20.42.8-1.7-0.5-0.5-0.50.4-0.40.20.20.2-0.3-0.3-0.4-0.90.60.5-0.6-0.6-0.4-0.4-0.9-1.1
Progressive ratio test 1 breakpoint0.20.42.9-1.7-0.5-0.5-0.50.6-0.50.10.20.2-0.3-0.3-0.3-0.90.60.5-0.6-0.6-0.4-0.4-0.9-1.1
Progressive ratio test 1 inactive lever presses0.10.30.7-0.50.20.20.2-0.60.30.60.60.60.20.2-0.7-0.10.80.8-0.8-0.8-0.7-0.7-0.5-0.8
Progressive ratio test 2 active lever presses0.30.52.2-1.5-0.4-0.4-0.40.3-0.20.30.30.4-0.1-0.1-0.5-0.90.70.7-0.7-0.7-0.7-0.7-0.7-1.5
Progressive ratio test 2 breakpoint0.40.52.3-1.4-0.4-0.4-0.40.2-0.20.40.40.5-0.1-0.1-0.6-0.80.80.8-0.8-0.8-0.8-0.8-0.6-1.5
Progressive ratio test 2 inactive lever presses0.00.10.3-0.30.20.20.20.20.20.40.40.30.20.2-0.40.10.40.4-0.4-0.4-0.4-0.40.6-0.3
Incentive Sensitization - Responses0.10.41.3-1.0-0.8-0.8-0.80.6-0.7-0.2-0.2-0.2-0.7-0.70.1-1.20.10.1-0.1-0.1-0.2-0.2-0.3-1.1
Incentive Sensitization - Breakpoint0.10.21.0-0.8-0.6-0.6-0.60.3-0.5-0.1-0.1-0.1-0.5-0.5-0.0-1.00.20.2-0.2-0.2-0.3-0.3-0.2-1.0
Sum of active levers in priming session hrs 5-60.10.10.7-0.2-0.1-0.1-0.1-0.2-0.2-0.1-0.1-0.2-0.2-0.20.2-0.1-0.2-0.20.10.20.20.2-0.80.1
Progressive ratio0.20.51.5-0.1-0.6-0.5-0.50.9-1.2-0.5-0.5-0.5-1.2-1.20.4-1.0-0.3-0.40.10.30.60.60.5-0.2
Food seeking constrained by brief footshock0.30.42.21.50.90.90.9-0.10.20.70.70.60.10.1-0.60.50.80.5-0.6-0.7-0.4-0.40.80.1
Seeking ratio, punishment vs. effort0.20.61.11.10.90.90.9-0.91.00.70.70.70.90.9-0.61.10.60.5-0.3-0.5-0.6-0.6-0.00.3
Retroperitoneal fat weight0.52.14.4-1.8-1.7-1.7-1.70.7-1.9-1.3-1.3-1.3-2.1-2.11.1-2.1-0.9-1.10.90.91.11.1-1.4-0.4
Reaction time number correct0.41.54.8-1.9-1.6-1.6-1.60.7-1.5-0.9-0.9-0.8-1.3-1.30.6-2.2-0.3-0.30.50.30.40.4-2.0-1.0
Reaction time mean minus median0.10.61.0-0.30.60.60.6-1.00.90.80.80.80.70.7-0.80.50.90.9-1.0-0.9-0.9-0.9-0.3-0.8
Reaction time mean minus median AUC0.00.21.20.30.30.40.4-0.40.6-0.0-0.0-0.00.50.50.10.9-0.0-0.30.00.10.30.31.10.9
Reaction time num false alarms0.30.64.2-2.0-1.0-1.0-1.00.5-0.7-0.6-0.6-0.5-0.5-0.50.4-1.1-0.2-0.10.20.30.20.2-1.0-0.7
Reaction time num false alarms AUC0.30.84.7-2.2-1.1-1.1-1.10.6-0.9-0.6-0.6-0.5-0.7-0.70.4-1.3-0.2-0.10.20.30.20.2-1.2-0.9
Reaction time trials correct on left0.41.54.8-1.9-1.6-1.6-1.60.7-1.5-0.9-0.9-0.8-1.3-1.30.6-2.2-0.3-0.30.50.30.40.4-2.0-1.0
Reaction time trials on left0.41.44.6-1.8-1.6-1.6-1.60.7-1.5-0.9-0.9-0.8-1.3-1.30.7-2.1-0.4-0.30.60.30.50.5-1.9-0.9
Reaction time mean0.10.10.6-0.00.10.10.1-0.50.4-0.2-0.2-0.20.20.20.30.5-0.3-0.30.30.30.30.30.80.6
Reaction time mean AUC0.10.10.6-0.10.10.00.0-0.40.4-0.3-0.3-0.30.20.20.30.5-0.4-0.30.30.40.30.30.80.7
Median of all reaction times0.20.31.0-0.1-0.2-0.3-0.3-0.10.0-0.7-0.7-0.7-0.1-0.10.70.3-0.7-0.70.80.80.70.70.91.0
Reaction time omissions0.30.42.41.50.80.80.8-0.70.80.40.40.40.70.7-0.30.80.10.2-0.2-0.1-0.2-0.20.90.5
Reaction time false alarm rate0.10.11.1-1.0-0.3-0.3-0.30.3-0.1-0.3-0.3-0.3-0.1-0.10.30.0-0.2-0.20.10.30.20.20.00.1
Reaction time premature initiation rate0.61.01.80.20.80.80.8-0.70.81.11.11.10.80.8-1.20.21.21.2-1.2-1.1-1.3-1.3-0.5-1.3
Reaction time premature initiations0.30.93.9-0.7-0.00.00.0-0.50.10.70.80.80.20.2-1.0-1.01.11.2-1.1-1.1-1.2-1.2-1.7-2.0
Std. dev. reaction times0.10.20.7-0.20.40.40.4-0.80.80.30.30.30.50.5-0.30.50.40.3-0.4-0.3-0.4-0.40.3-0.1
Reaction time trials completed0.41.44.6-1.8-1.6-1.6-1.60.7-1.5-0.9-0.9-0.8-1.3-1.30.7-2.1-0.4-0.30.60.30.50.5-1.9-0.9
Reaction time trials AUC0.51.65.5-2.0-1.7-1.7-1.70.7-1.6-0.9-0.9-0.8-1.4-1.40.6-2.3-0.3-0.30.50.20.40.4-2.1-1.2
Run reversals in cocaine runway, females0.60.71.20.81.11.11.1-0.50.80.80.80.81.01.0-0.81.00.80.7-0.8-0.8-0.5-0.50.60.3
Run reversals in cocaine runway, males1.71.93.21.31.71.71.7-1.81.21.51.51.51.51.5-1.41.41.31.3-1.3-1.3-1.2-1.2-0.2-0.1
Latency to leave start box in cocaine runway0.60.82.41.61.21.11.10.11.30.60.60.61.31.3-0.51.5-0.10.30.20.1-0.3-0.31.30.8
Latency to leave start box in cocaine runway, F0.70.93.51.40.60.60.60.80.7-0.2-0.2-0.20.80.80.41.5-1.0-0.71.11.00.40.41.91.8
Latency to leave start box in cocaine runway, M1.41.42.20.61.01.01.0-0.91.11.31.31.31.01.0-1.40.41.41.5-1.3-1.4-1.3-1.3-0.6-1.3
Std. dev. time between licks in bursts0.50.92.20.91.11.11.1-0.91.30.90.90.91.51.5-0.91.20.70.8-0.5-0.6-0.8-0.80.90.0
Total sessions with >9 infusions0.20.30.8-0.9-0.1-0.1-0.1-0.40.20.40.40.40.20.2-0.5-0.20.70.6-0.7-0.7-0.7-0.7-0.8-0.9
Short access day 1 total inactive lever presses0.20.30.60.10.40.40.4-0.60.50.70.60.60.30.3-0.70.20.80.7-0.8-0.8-0.7-0.70.5-0.6
Short access day 10 total inactive lever presses0.00.20.6-0.4-0.5-0.5-0.5-0.1-0.3-0.1-0.1-0.1-0.5-0.50.1-0.70.0-0.0-0.0-0.0-0.2-0.2-0.8-0.8
Short access day 1 total infusions0.20.30.6-0.00.50.50.5-0.50.60.70.70.70.50.5-0.70.40.80.7-0.8-0.8-0.6-0.60.2-0.5
Short access day 10 total infusions0.20.21.8-1.4-0.3-0.3-0.30.2-0.20.20.20.2-0.2-0.2-0.3-0.60.50.5-0.5-0.5-0.3-0.3-0.6-0.8
Short access total infusions0.20.20.6-0.50.20.20.20.00.30.50.50.50.30.3-0.6-0.00.70.6-0.7-0.7-0.6-0.6-0.1-0.8
Short access day 1 locomotion0.81.42.30.00.90.90.9-1.51.21.31.31.31.21.2-1.30.71.41.4-1.4-1.4-1.4-1.4-0.6-1.0
Short access day 10 total locomotion1.55.99.50.41.81.81.8-2.62.02.72.72.72.02.0-2.80.73.03.0-3.0-3.0-3.1-3.1-1.0-2.9
Short access total locomotion1.42.23.4-0.11.11.11.1-1.81.31.61.61.61.31.3-1.70.61.81.7-1.8-1.8-1.9-1.9-1.0-1.6
One hour access (0.3 mA shock)0.10.11.2-1.1-0.4-0.4-0.40.5-0.3-0.1-0.1-0.1-0.3-0.30.0-0.30.10.1-0.1-0.10.10.10.1-0.2
Compulsive drug intake0.81.23.60.9-0.3-0.3-0.30.5-0.4-1.1-1.1-1.1-0.4-0.41.30.5-1.5-1.41.51.51.41.41.11.9
One hour access (shock baseline)0.20.62.0-1.40.10.10.1-0.10.20.70.70.80.30.3-0.9-0.41.11.1-1.1-1.1-0.9-0.9-0.5-1.3
Social response proportion1.01.34.62.11.41.41.4-1.11.31.11.11.01.11.1-1.01.10.70.9-0.7-0.7-0.8-0.81.60.1
Social responses6.68.612.62.73.43.43.4-3.23.53.13.13.13.43.4-3.02.92.62.8-2.8-2.6-2.9-2.91.3-1.0
Social time0.40.61.70.0-0.6-0.6-0.61.3-0.8-0.7-0.7-0.8-0.9-0.90.8-0.6-1.2-0.80.91.00.70.7-0.10.4
Soleus weight7.522.027.4-4.6-4.9-4.9-4.94.7-4.8-5.2-5.2-5.2-4.7-4.75.2-3.7-5.0-5.05.04.95.05.0-1.32.7
Bone: stiffness1.93.55.5-1.7-1.7-1.7-1.72.0-1.5-2.1-2.1-2.1-1.5-1.52.2-0.6-2.2-2.32.22.22.22.20.31.7
Tibialis anterior weight1.03.34.3-1.8-1.9-1.9-1.91.5-2.1-2.0-2.0-2.0-1.9-1.92.0-1.6-1.8-1.91.91.92.02.0-0.91.0
Time to tail flick, vehicle, before self-admin0.10.21.00.50.50.50.5-1.00.40.30.30.30.30.3-0.20.50.20.2-0.2-0.2-0.0-0.0-0.80.4
Time to tail flick, vehicle, after self-admin0.30.73.1-1.1-0.2-0.2-0.20.0-0.10.60.60.6-0.1-0.1-0.8-0.70.90.9-0.9-0.9-1.0-1.0-1.5-1.8
Time to tail flick, test, before self-admin0.40.51.30.80.80.80.8-0.50.90.60.50.50.90.9-0.51.10.30.4-0.4-0.3-0.4-0.40.90.5
Time to tail flick, test, after self-admin0.10.10.50.20.30.40.4-0.70.30.40.40.40.20.2-0.40.20.50.4-0.4-0.5-0.2-0.2-0.5-0.1
Delta time to tail flick, vehicle, before/after SA0.70.82.7-1.6-1.1-1.1-1.11.2-1.0-0.4-0.4-0.4-1.0-1.00.2-1.4-0.0-0.0-0.00.0-0.0-0.0-1.0-1.3
Delta time to tail flick, test, before/after SA0.30.32.0-0.9-0.5-0.5-0.5-0.3-0.50.00.00.0-0.6-0.6-0.2-1.00.40.3-0.3-0.4-0.1-0.1-1.4-1.0
Tibia length0.71.92.81.01.41.41.4-1.51.41.51.51.51.41.4-1.50.81.31.7-1.6-1.4-1.6-1.60.3-1.1
Ambulatory time before self-admin0.10.20.40.1-0.3-0.3-0.30.1-0.2-0.5-0.5-0.5-0.2-0.20.5-0.1-0.6-0.60.60.60.40.4-0.00.6
Ambulatory time after self-admin0.00.00.20.30.10.10.1-0.50.2-0.0-0.0-0.00.10.10.10.2-0.1-0.10.10.10.00.0-0.10.3
Bone: tissue strength1.51.62.8-0.3-1.0-1.0-1.01.3-1.1-1.4-1.5-1.5-1.2-1.21.5-0.7-1.7-1.51.61.61.51.50.51.2
Total heroin consumption1.41.62.41.31.51.51.5-1.31.31.41.41.41.41.4-1.41.31.21.3-1.2-1.2-1.1-1.1-0.1-0.3
Bone: trabecular number0.51.02.91.11.31.31.3-0.51.30.80.80.81.41.4-0.61.70.60.5-0.5-0.6-0.4-0.41.40.8
Bone: trabecular spacing1.21.86.2-2.1-1.6-1.6-1.60.7-1.7-0.8-0.8-0.7-1.7-1.70.5-2.3-0.2-0.20.30.20.20.2-2.5-1.7
Bone: trabecular thickness1.62.210.72.51.41.31.3-0.01.4-0.2-0.2-0.21.51.50.52.3-0.9-0.81.00.90.70.73.32.8
Bone: trabecular tissue density1.01.83.0-0.7-1.4-1.4-1.41.3-1.7-1.4-1.4-1.4-1.7-1.71.4-1.6-1.3-1.31.31.31.31.3-0.40.4
Water consumed over 24 hours0.40.71.3-0.5-0.6-0.7-0.70.7-0.7-1.0-1.0-1.0-0.5-0.51.1-0.2-0.9-1.11.20.81.11.1-0.31.1
Number of responses in last shaping day1.11.42.5-0.00.70.70.7-1.40.81.31.31.31.01.0-1.40.31.61.5-1.6-1.6-1.4-1.4-1.0-1.4