Hub : Genes

Cavin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	Cavin2	0.03	0.02	2.0e-03	0	0	0	0	9.5e-02	8.1e-02	2.7e-01	2.8e-01
2	Adipose	gene expression	Cavin2	0.26	0.14	0.0e+00	0.18	0.19	0.2	0.17	4.0e-19	7.8e-21	3.8e-22	5.4e-19

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.6	1.1	1.9	-1.4	0.4
Area under the delay curve	4.8	5.1	7.4	1.6	-2.7
BMI with tail	4.9	16.0	19.2	4.4	-3.6
BMI without tail	0.6	1.3	1.9	1.4	-0.8
Body weight	0.3	1.4	1.7	-1.0	1.3
Weight adjusted by age	0.2	0.2	0.3	-0.1	-0.6
Bone surface	0.3	0.5	0.9	-0.9	0.5
Bone volume	0.8	1.4	2.3	-1.5	0.7
Breakpoint value in progressive ratio session	1.3	1.5	1.9	-1.0	1.4
Number of licking bursts	0.3	0.4	0.6	-0.4	0.8
Context. condit. distance diff. score	1.9	2.3	2.4	1.5	-1.5
Locomotion velocity, session 1	2.2	2.3	2.4	1.5	-1.6
Locomotion distance, session 1	1.6	2.0	2.1	1.4	-1.4
Locomotion velocity, session 2	3.6	4.2	5.3	2.3	-1.7
Locomotion distance, session 2	0.2	0.2	0.4	0.7	-0.1
Locomotion velocity, session 3	0.9	1.0	1.7	-0.6	1.3
Locomotion distance, session 3	0.2	0.3	0.5	-0.2	0.7
Stereotopy head waving bouts, day 3	0.4	0.5	1.0	0.1	1.0
Stereotopy head waving duration, day 3	0.6	0.7	1.4	-0.3	1.2
Locomotion velocity, session 7	2.8	3.0	3.4	1.6	-1.9
Locomotion distance, session 7	1.3	1.6	1.8	1.3	-1.2
Stereotopy head waving bouts, day 7	1.2	1.3	1.8	-0.9	1.3
Stereotopy head waving duration, day 7	1.4	1.8	2.1	-1.2	1.5
Locomotion velocity, session 8	2.3	2.8	3.4	1.5	-1.8
Locomotion distance, session 8	2.9	4.3	4.3	2.0	-2.1
Degree of sensitization distance	0.8	0.8	1.2	0.7	-1.1
Degree of sensitization stereotypy	0.1	0.1	0.2	-0.4	0.3
Conditioned locomotion	3.3	3.9	4.0	-2.0	2.0
Cocaine response after cond. corrected	0.2	0.2	0.4	-0.6	0.3
Cocaine response after cond. not corrected	1.4	1.5	1.7	-1.3	1.1
Cocaine response before conditioning	0.9	1.1	1.5	-0.8	1.2
Saline control response	0.0	0.0	0.0	0.0	0.1
Bone: connectivity density	0.0	0.0	0.1	-0.2	-0.3
Bone: cortical apparent density	6.4	8.5	11.5	3.4	-2.3
Bone: cortical area	0.2	0.4	0.6	-0.4	0.8
Bone: cortical porosity	3.4	3.7	4.9	-2.2	1.6
Bone: cortical porosity	3.3	3.6	5.3	-2.3	1.4
Bone: cortical thickness	0.5	0.8	1.3	1.1	-0.5
Bone: cortical thickness	0.1	0.1	0.2	0.4	-0.2
Bone: cortical tissue density	6.4	8.5	11.5	3.4	-2.3
Condit. Reinf. active minus inactive responses	4.9	5.5	6.9	-2.6	2.0
Condit. Reinf. active-inactive response ratio	3.2	3.5	4.2	-2.0	1.7
Condit. Reinf. active responses	2.3	2.8	4.2	-2.1	1.2
Condit. Reinf. inactive responses	0.3	0.4	0.7	0.3	-0.8
Incentive salience index mean	1.3	1.6	2.9	-1.7	0.6
Condit. Reinf. lever presses	0.7	0.9	1.8	0.1	-1.3
Condit. Reinf. active minus inactive responses	3.4	4.2	5.5	-2.3	1.7
Condit. Reinf. active-inactive response ratio	2.8	2.9	3.8	-2.0	1.4
Condit. Reinf. active responses	0.7	1.0	1.3	-1.1	0.9
Condit. Reinf. inactive responses	0.9	1.1	1.2	1.0	-1.1
Condit. Reinf. lever presses	0.5	0.6	0.9	0.6	-0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	0.9	-1.0	0.6
Conditioned reinforcement - actives	0.7	0.7	0.8	-0.7	0.9
Conditioned reinforcement - inactives	3.2	3.6	4.9	-1.5	2.2
Conditioned locomotion	0.6	0.8	1.4	1.2	-0.4
Patch foraging indifference point 0 sec	7.8	12.6	13.6	3.4	-3.7
Patch foraging indifference point AUC	0.6	0.7	0.8	0.9	-0.8
Delay disc. indifference point, 0s delay	4.0	4.4	5.8	1.7	-2.4
Delay disc. indifference point, 16s delay	3.3	3.4	5.4	1.2	-2.3
Delay disc. indifference point, 2s delay	2.0	2.2	3.4	1.0	-1.9
Delay disc. indifference point, 24s delay	0.6	0.6	0.9	0.5	-0.9
Delay disc. indifference point, 4s delay	3.3	3.5	4.7	1.5	-2.2
Delay disc. indifference point, 8s delay	2.6	2.7	4.5	0.9	-2.1
Indifference point function ln k	2.3	3.1	3.9	1.6	-2.0
Indifference point function log k	2.3	3.1	3.9	1.6	-2.0
Patch foraging total patch changes 0 sec	7.4	12.0	12.6	3.4	-3.5
Patch foraging total patch changes 12 sec	1.7	2.2	2.4	1.5	-1.5
Patch foraging total patch changes 18 sec	4.4	5.7	6.3	2.5	-2.3
Patch foraging total patch changes 24 sec	2.4	2.9	3.1	1.8	-1.6
Patch foraging total patch changes 6 sec	6.0	8.8	8.9	3.0	-3.0
Patch foraging time to switch 0 sec	1.7	2.6	2.8	-1.6	1.7
Patch foraging water rate 0 sec	0.9	1.4	1.8	1.3	-1.1
Patch foraging water rate 12 sec	1.2	1.9	1.9	1.3	-1.4
Patch foraging water rate 18 sec	0.0	0.1	0.1	-0.3	0.2
Patch foraging water rate 24 sec	0.6	0.8	1.1	-0.7	1.0
Patch foraging water rate 6 sec	1.0	1.5	1.6	1.2	-1.3
Seeking ratio, delayed vs. immediate footshock	1.7	2.0	2.4	-1.6	1.3
Distance traveled before self-admin	4.0	4.2	5.9	-2.4	1.6
Distance traveled after self-admin	0.2	0.3	0.4	-0.7	-0.3
Extensor digitorum longus weight	1.8	7.1	10.9	3.3	-1.8
Bone: elastic displacement	0.4	0.4	0.6	-0.5	0.8
Bone: elastic work	1.6	2.1	2.6	-1.6	1.3
Bone: endosteal estimation	2.8	6.2	8.5	-2.9	2.0
Bone: endosteal perimeter	3.3	6.9	7.2	-2.6	2.7
Epididymis fat weight	0.8	1.8	2.0	-1.4	1.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	-0.1
Delta time in open arm before/after self-admin	1.9	1.8	3.2	-1.8	0.7
Diff in mean of infusions in LGA sessions	0.9	1.0	1.4	-1.2	0.8
Delay discount exponential model param	4.2	4.4	6.5	-1.5	2.6
Extinction: sum of active levers before priming	1.2	1.2	1.5	-1.2	1.0
Active lever presses in extinction session 6	0.3	0.3	0.4	-0.7	0.5
Bone: final force	2.7	4.4	4.5	-2.0	2.1
Bone: final moment	2.1	3.4	3.9	-1.7	2.0
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.1	-0.5
Glucose	0.1	0.1	0.2	0.4	-0.1
Heart weight	0.0	0.1	0.1	-0.3	-0.2
Delay discount hyperbolic model param	4.6	4.9	7.1	-1.6	2.7
Intermittent access intake day 1-15 change	0.3	0.3	0.6	0.8	-0.0
Intermittent access intake escalation	0.2	0.2	0.4	0.6	-0.1
Intermittent access intake escalation 2	0.0	0.0	0.1	0.3	-0.0
Intermitt. access day 1 inactive lever presses	0.9	1.0	1.7	-0.5	1.3
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.4	-0.7	0.2
Intermitt. access escalation Index	0.4	0.4	0.6	-0.3	0.8
Intermittent access day 1 total infusions	0.2	0.2	0.3	-0.5	0.5
Intermittent access day 15 total infusions	0.3	0.4	0.8	-0.1	0.9
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.2	0.3	0.5
Intermittent access total infusions	0.6	0.7	1.1	-0.6	1.0
Intermittent access day 1 locomotion	0.5	0.6	0.7	0.6	-0.8
Intermittent access day 15 total locomotion	0.1	0.1	0.2	0.4	-0.3
Intermittent access total locomotion	0.3	0.4	0.5	0.7	-0.5
Intermittent access standard deviation	0.1	0.1	0.1	0.4	0.4
Left kidney weight	0.3	0.9	1.0	-1.0	0.9
Right kidney weight	0.1	0.2	0.3	0.3	-0.6
Cocaine induced anxiety	0.8	1.0	1.8	1.3	-0.4
Post-drug Anxiety	0.4	0.4	0.8	0.1	0.9
Baseline Anxiety	2.8	3.0	3.3	-1.8	1.7
Tail length	6.5	19.7	22.4	-4.7	4.1
Length with tail	7.1	26.1	28.4	-5.3	4.9
Length without tail	0.6	1.4	1.5	-1.2	1.1
Times rat made contact with spout	1.3	1.5	2.2	-0.9	1.5
Lifetime Intake	0.3	0.3	0.6	-0.3	0.7
Liver weight, left	0.1	0.1	0.2	-0.2	-0.4
Liver weight, right	0.1	0.2	0.3	-0.4	0.5
Locomotor activity	0.3	0.4	0.6	0.4	-0.8
Locomotor testing distance	0.7	1.2	1.8	0.7	-1.3
Locomotor testing rearing	0.2	0.3	0.3	0.5	-0.6
Locomotion in novel chamber	0.2	0.3	0.5	0.7	0.0
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	0.1	0.5
Fecal boli incidents, locomotor time 1	3.7	4.0	4.7	1.8	-2.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.5	-0.7	0.5
Time >=10cm from walls, locomotor time 1	0.9	0.9	1.8	0.3	-1.3
Bouts of movement, locomotor time 1	3.8	4.1	5.2	1.7	-2.3
Total resting periods, locomotor time 1	4.7	5.1	6.3	2.0	-2.5
Rest time, locomotor task time 1	1.5	1.7	2.1	1.2	-1.4
Distance moved, locomotor task time 1	0.5	0.5	0.7	-0.8	0.6
Vertical activity count, locomotor time 1	0.4	0.4	0.4	-0.6	0.6
Time >=10cm from walls, locomotor time 2	1.2	1.2	1.8	-1.4	0.8
Bouts of movement, locomotor time 2	3.0	3.3	3.8	1.9	-1.7
Total resting periods, locomotor time 2	4.1	4.4	4.9	2.2	-2.0
Rest time, locomotor task time 2	0.8	0.9	1.0	0.9	-1.0
Distance moved, locomotor task time 2	0.3	0.3	0.4	-0.6	0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.2	-0.1	0.4
Light reinforcement 1	1.4	2.6	3.6	1.9	-1.2
Light reinforcement 2	0.0	0.1	0.1	0.3	-0.2
Bone: marrow area	2.7	5.9	8.1	-2.8	1.9
Bone: maximum diameter	0.8	1.5	2.1	-0.9	1.5
Bone: maximum force	2.3	3.9	4.8	-2.2	1.8
Bone: maximum moment	1.7	2.9	3.4	-1.8	1.6
Mean time between licks in bursts	0.4	0.5	1.1	1.0	0.0
Mean num. licks in bursts	0.1	0.2	0.2	0.3	-0.5
Cd content in liver	0.0	0.0	0.0	-0.2	0.1
Co content in liver	1.5	1.8	2.8	0.9	-1.7
Cu content in liver	0.2	0.3	0.4	-0.6	0.4
Fe content in liver	3.3	4.0	4.4	-2.1	1.9
K content in liver	0.6	0.6	0.7	0.9	-0.7
Mg content in liver	0.4	0.4	0.8	-0.1	0.9
Mn content in liver	0.2	0.3	0.5	0.7	-0.2
Na content in liver	1.5	1.6	2.1	1.0	-1.5
Rb content in liver	0.1	0.1	0.1	0.3	0.3
Se content in liver	0.7	0.9	1.4	-0.6	1.2
Sr content in liver	0.1	0.0	0.1	0.3	-0.0
Zn content in liver	0.1	0.1	0.2	0.5	0.0
Bone: minimum diameter	0.8	1.5	1.8	-1.3	1.1
Time in familiar zone, hab. session 1	0.3	0.2	0.5	0.7	-0.1
Time in novel zone, hab. session 1	1.9	1.8	3.0	-1.7	0.8
Total zone transitions, hab. session 1	0.3	0.4	0.7	0.2	-0.9
Total locomotion distance, hab. session 1	0.3	0.4	0.7	-0.8	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.4	-0.6	0.2
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.3	0.4
Time in novel zone, hab. session 2	0.2	0.2	0.3	-0.3	0.5
Total zone transitions, hab. session 2	0.2	0.3	0.4	0.5	-0.6
Total locomotion distance, hab. session 2	0.6	0.8	1.0	-1.0	0.8
Locomotion velocity, hab. session 2	0.3	0.4	0.5	-0.7	0.5
Novel to familiar place preference ratio	3.5	3.6	4.3	-2.1	1.7
Novelty place preference	3.7	3.8	4.0	-2.0	1.9
Time in novel zone, NPP test	4.6	4.7	5.0	-2.2	2.1
Total zone transitions, NPP test	0.6	0.8	1.0	1.0	-0.8
Total locomotion distance, NPP test	0.0	0.0	0.0	-0.2	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.2	0.2	-0.5
Intraocular pressure	0.2	0.3	0.7	0.8	0.1
Delta distance traveled before/after self-admin	1.2	1.3	1.4	1.2	-1.1
Delta ambulatory time before/after self-admin	2.1	2.3	2.5	1.5	-1.6
Parametrial fat weight	0.0	0.0	0.0	-0.0	-0.2
Pavlov. Cond. lever latency	0.6	0.7	1.2	0.5	1.1
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	-0.9	-0.4
Pavlov. Cond. change in total contacts	0.6	0.6	1.1	-0.2	-1.1
Pavlov. Cond. index score	0.4	0.5	0.6	-0.6	-0.8
Pavlov. Cond. latency score	0.5	0.6	0.8	-0.6	-0.9
Pavlov. Cond. lever contacts	0.5	0.6	1.2	-0.2	-1.1
Pavlov. Cond. magazine entry number	0.8	1.1	2.1	1.4	-0.1
Pavlov. Cond. intertrial magazine entries	2.6	3.2	4.7	-1.3	2.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.6	-0.5	-0.8
Pavlov. Cond. response bias	0.3	0.4	0.4	-0.7	-0.6
Pavlov. Cond. lever latency	0.8	1.0	1.5	-0.7	1.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.3
Pavlov. Cond. change in total contacts	0.3	0.4	0.9	0.1	-0.9
Pavlov. Cond. index score	0.3	0.3	0.5	0.4	-0.7
Pavlov. Cond. latency score	0.2	0.2	0.3	0.2	-0.6
Pavlov. Cond. lever contacts	0.6	0.8	1.4	0.5	-1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	0.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.5	-0.7
Pavlov. Cond. response bias	0.1	0.2	0.4	0.1	-0.6
Time in closed arm before self-admin	1.1	1.2	2.1	-1.4	0.6
Time in closed arm after self-admin	0.2	0.2	0.5	0.1	-0.7
Time in open arm before self-admin	0.5	0.6	0.9	0.9	0.5
Time in open arm after self-admin	1.8	2.0	2.9	-1.7	1.0
Bone: periosteal estimation	2.3	4.8	5.9	-2.4	2.0
Bone: periosteal perimeter	2.9	4.9	5.5	-2.1	2.4
Bone: post-yield work	0.8	1.2	1.7	-1.3	0.8
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.2	-0.0
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.4	-0.2
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.5	0.2	0.7
Progressive ratio test 2 active lever presses	0.7	0.8	1.0	-0.7	1.0
Progressive ratio test 2 breakpoint	0.1	0.2	0.2	-0.3	0.5
Progressive ratio test 2 inactive lever presses	1.6	1.9	2.8	-1.0	1.7
Incentive Sensitization - Responses	1.7	1.7	1.7	-1.3	1.3
Incentive Sensitization - Breakpoint	1.7	1.8	1.9	-1.3	1.4
Sum of active levers in priming session hrs 5-6	2.0	2.0	2.5	-1.6	1.2
Progressive ratio	0.2	0.3	0.5	-0.1	0.7
Food seeking constrained by brief footshock	0.6	0.7	0.7	-0.9	0.8
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	-0.1	-0.4
Retroperitoneal fat weight	0.2	0.5	0.8	0.4	-0.9
Reaction time number correct	0.4	0.5	1.0	0.2	1.0
Reaction time mean minus median	1.8	2.3	3.9	-2.0	0.8
Reaction time mean minus median AUC	1.7	2.2	3.5	-1.9	0.9
Reaction time num false alarms	2.8	3.8	5.8	2.4	-1.3
Reaction time num false alarms AUC	2.4	3.3	5.3	2.3	-1.1
Reaction time trials correct on left	0.4	0.5	1.0	0.2	1.0
Reaction time trials on left	0.5	0.6	1.3	0.1	1.1
Reaction time mean	7.7	10.8	13.8	-3.7	2.8
Reaction time mean AUC	7.8	10.6	13.1	-3.6	2.8
Median of all reaction times	8.0	11.0	13.4	-3.7	2.9
Reaction time omissions	1.3	1.8	2.1	-1.4	1.2
Reaction time false alarm rate	2.4	3.4	4.2	2.1	-1.6
Reaction time premature initiation rate	0.6	0.8	1.3	0.6	-1.1
Reaction time premature initiations	0.2	0.3	0.4	0.6	-0.5
Std. dev. reaction times	4.7	6.6	9.5	-3.1	1.9
Reaction time trials completed	0.5	0.6	1.3	0.1	1.1
Reaction time trials AUC	0.4	0.6	1.1	0.1	1.0
Run reversals in cocaine runway, females	0.5	0.5	0.6	-0.6	0.8
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.4	-0.2
Latency to leave start box in cocaine runway	5.0	5.4	8.1	2.9	-1.6
Latency to leave start box in cocaine runway, F	2.0	2.2	3.3	1.8	-1.1
Latency to leave start box in cocaine runway, M	3.8	3.7	5.2	2.3	-1.4
Std. dev. time between licks in bursts	2.0	2.3	3.7	1.9	-1.0
Total sessions with >9 infusions	0.4	0.4	0.8	0.9	-0.1
Short access day 1 total inactive lever presses	0.6	0.7	0.9	-0.7	0.9
Short access day 10 total inactive lever presses	1.4	1.6	2.0	-1.1	1.4
Short access day 1 total infusions	0.2	0.2	0.3	-0.0	0.6
Short access day 10 total infusions	0.3	0.4	0.6	-0.3	0.8
Short access total infusions	0.1	0.1	0.2	0.4	-0.1
Short access day 1 locomotion	0.2	0.2	0.3	0.2	0.5
Short access day 10 total locomotion	1.7	1.9	2.8	1.0	-1.7
Short access total locomotion	0.1	0.1	0.3	0.5	-0.1
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.2	-0.1
Compulsive drug intake	0.5	0.5	0.7	0.5	-0.9
One hour access (shock baseline)	1.1	1.2	1.5	-1.0	1.2
Social response proportion	1.1	1.2	1.9	-1.4	0.7
Social responses	0.1	0.1	0.2	-0.5	0.0
Social time	1.0	1.4	2.1	-1.4	0.8
Soleus weight	0.1	0.4	0.6	0.7	-0.5
Bone: stiffness	1.0	1.5	2.1	-1.4	1.0
Tibialis anterior weight	1.0	3.3	4.6	2.1	-1.4
Time to tail flick, vehicle, before self-admin	1.2	1.2	1.3	1.0	-1.2
Time to tail flick, vehicle, after self-admin	0.2	0.2	0.4	0.0	-0.6
Time to tail flick, test, before self-admin	0.3	0.3	0.4	0.4	0.6
Time to tail flick, test, after self-admin	1.7	1.8	2.2	1.5	-1.1
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.6	-0.8	0.3
Delta time to tail flick, test, before/after SA	1.8	1.7	2.5	0.9	-1.6
Tibia length	3.9	10.9	13.6	-3.7	2.9
Ambulatory time before self-admin	4.2	4.3	5.4	-2.3	1.8
Ambulatory time after self-admin	0.7	0.8	1.3	0.5	-1.2
Bone: tissue strength	0.3	0.3	0.3	-0.5	0.6
Total heroin consumption	0.4	0.5	0.6	-0.8	0.6
Bone: trabecular number	0.2	0.3	0.5	-0.7	-0.1
Bone: trabecular spacing	0.3	0.4	0.5	0.6	-0.7
Bone: trabecular thickness	0.3	0.3	0.6	-0.8	-0.2
Bone: trabecular tissue density	0.0	0.0	0.0	-0.0	-0.0
Water consumed over 24 hours	0.3	0.3	0.5	0.7	-0.4
Number of responses in last shaping day	0.2	0.2	0.3	0.6	0.3