Hub : Genes

Casz1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr5_164670614_164670865	0.04	0.03	8.3e-04	0.03	0.04	0.04	0.03	4.0e-03	6.9e-04	7.9e-04	1.1e-03
2	NAcc	isoform ratio	XM_008764317.4	0.02	0.02	9.7e-03	0.01	0.01	0	0.01	1.1e-02	1.6e-02	5.3e-02	2.9e-02
3	NAcc	isoform ratio	NM_001427668.1	0.01	0.01	7.3e-03	0.01	0.01	0	0.01	3.0e-02	9.8e-03	1.0e-01	3.0e-02
4	IC	mRNA stability	Casz1	0.05	0.04	4.6e-03	0.04	0.05	0.03	0.04	9.0e-03	4.0e-03	3.1e-02	9.4e-03
5	Brain	intron excision ratio	chr5_164670614_164670865	0.12	0.11	1.1e-04	0.04	0.04	0.07	0.05	1.4e-04	2.5e-04	8.7e-07	3.2e-05
6	PL	intron excision ratio	chr5_164670614_164670865	0.06	0.04	5.0e-03	0.01	0.01	0.03	0.02	4.6e-02	1.1e-02	4.0e-04	5.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.0	-0.0
Area under the delay curve	0.6	0.9	1.3	-0.8	-0.8	-0.9	0.9	1.0	1.1
BMI with tail	0.1	0.2	0.4	-0.5	-0.6	-0.5	0.5	0.2	0.5
BMI without tail	0.0	0.2	0.5	0.1	0.2	0.1	-0.1	0.6	0.7
Body weight	0.1	0.6	0.9	0.9	0.9	0.9	-0.9	-0.5	-0.1
Weight adjusted by age	1.2	3.4	5.9	1.6	1.6	1.6	-1.6	-2.1	-2.4
Bone surface	0.7	1.3	1.9	1.0	1.0	1.1	-1.0	-1.3	-1.4
Bone volume	0.2	0.4	0.7	0.6	0.5	0.6	-0.6	-0.8	-0.8
Breakpoint value in progressive ratio session	0.2	0.4	0.8	-0.8	-0.9	-0.5	0.6	-0.4	-0.3
Number of licking bursts	0.4	1.3	2.2	-1.4	-1.5	-1.3	1.4	0.5	0.1
Context. condit. distance diff. score	3.5	4.3	4.8	-2.2	-2.1	-2.2	2.2	2.0	1.8
Locomotion velocity, session 1	0.3	0.4	0.4	-0.6	-0.6	-0.6	0.6	0.6	0.5
Locomotion distance, session 1	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.3	0.6	0.6
Locomotion velocity, session 2	0.6	0.7	1.1	-1.0	-1.0	-1.0	1.0	0.4	0.2
Locomotion distance, session 2	0.0	0.0	0.0	0.0	-0.0	0.1	-0.1	0.0	0.1
Locomotion velocity, session 3	1.1	1.3	1.5	-1.2	-1.2	-1.2	1.2	1.1	1.0
Locomotion distance, session 3	0.6	0.7	1.1	-1.0	-1.0	-0.9	0.9	0.6	0.5
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1	-0.1
Stereotopy head waving duration, day 3	0.1	0.2	0.2	0.5	0.5	0.5	-0.5	0.0	0.1
Locomotion velocity, session 7	0.4	0.4	1.7	-0.1	-0.2	-0.1	0.1	-1.0	-1.3
Locomotion distance, session 7	0.1	0.1	0.3	0.1	0.1	0.1	-0.1	-0.6	-0.6
Stereotopy head waving bouts, day 7	1.7	1.9	2.3	-1.5	-1.5	-1.5	1.5	1.3	1.0
Stereotopy head waving duration, day 7	0.9	1.1	1.6	-0.9	-0.9	-1.0	0.9	1.3	1.1
Locomotion velocity, session 8	2.2	2.6	4.0	-2.0	-2.0	-1.9	1.9	0.7	0.3
Locomotion distance, session 8	2.5	3.6	4.4	-2.1	-2.1	-2.0	2.1	1.6	1.4
Degree of sensitization distance	0.3	0.3	0.4	0.6	0.6	0.5	-0.5	-0.6	-0.5
Degree of sensitization stereotypy	0.4	0.5	0.6	-0.8	-0.8	-0.8	0.8	0.6	0.4
Conditioned locomotion	2.7	3.2	4.0	-2.0	-1.9	-2.0	2.0	1.4	1.1
Cocaine response after cond. corrected	0.7	1.0	1.3	1.1	1.2	1.0	-1.1	-0.8	-0.8
Cocaine response after cond. not corrected	0.6	0.8	1.2	1.1	1.1	1.0	-1.0	-0.6	-0.6
Cocaine response before conditioning	0.0	0.0	0.0	-0.0	-0.1	-0.0	0.0	0.1	0.2
Saline control response	0.2	0.3	0.4	0.6	0.6	0.6	-0.6	-0.4	-0.3
Bone: connectivity density	0.0	0.0	0.1	0.1	0.0	0.2	-0.1	-0.2	-0.4
Bone: cortical apparent density	2.3	3.7	4.1	1.9	1.9	1.9	-1.9	-2.0	-1.9
Bone: cortical area	0.8	1.4	1.5	1.2	1.2	1.2	-1.2	-1.2	-1.0
Bone: cortical porosity	0.9	1.0	1.1	-1.0	-1.1	-1.0	1.0	1.0	0.8
Bone: cortical porosity	0.6	0.7	0.9	-0.9	-0.9	-0.9	0.9	0.8	0.6
Bone: cortical thickness	0.6	1.0	1.9	0.7	0.7	0.8	-0.8	-1.4	-1.3
Bone: cortical thickness	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	-0.3	-0.2
Bone: cortical tissue density	2.3	3.6	4.0	1.9	1.9	1.9	-1.9	-2.0	-1.9
Condit. Reinf. active minus inactive responses	0.3	0.3	0.5	0.7	0.7	0.7	-0.7	-0.2	0.2
Condit. Reinf. active-inactive response ratio	2.2	2.4	3.5	1.9	1.9	1.8	-1.8	-0.8	-0.4
Condit. Reinf. active responses	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	0.3	0.4
Condit. Reinf. inactive responses	3.1	4.0	5.2	-2.3	-2.3	-2.2	2.2	1.5	1.2
Incentive salience index mean	2.2	2.8	3.2	1.8	1.7	1.8	-1.8	-1.7	-1.4
Condit. Reinf. lever presses	2.5	3.7	4.5	1.9	1.8	1.9	-1.9	-2.1	-1.9
Condit. Reinf. active minus inactive responses	0.6	1.0	1.1	-1.0	-1.0	-1.0	1.0	1.0	0.9
Condit. Reinf. active-inactive response ratio	0.2	0.3	0.4	-0.5	-0.4	-0.5	0.5	0.7	0.6
Condit. Reinf. active responses	0.9	1.3	1.8	-1.3	-1.3	-1.2	1.2	0.9	0.7
Condit. Reinf. inactive responses	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.0	-0.2	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.6	-0.6	-0.5	0.5	-0.1	-0.2
Condit. Reinf. lever reinforcers received	0.8	1.1	1.6	-1.2	-1.3	-1.1	1.2	0.7	0.6
Conditioned reinforcement - actives	0.3	1.3	1.5	-1.2	-1.2	-1.2	1.2	1.0	0.8
Conditioned reinforcement - inactives	0.1	0.2	0.6	-0.0	-0.1	-0.1	0.0	0.8	0.8
Conditioned locomotion	0.6	0.9	1.4	-1.2	-1.1	-1.1	1.2	0.5	0.1
Patch foraging indifference point 0 sec	0.4	1.2	1.8	1.3	1.3	1.3	-1.3	-0.6	-0.5
Patch foraging indifference point AUC	0.3	0.7	1.3	0.7	0.6	0.7	-0.7	-1.1	-1.1
Delay disc. indifference point, 0s delay	0.7	0.8	1.7	-0.6	-0.5	-0.7	0.6	1.3	1.3
Delay disc. indifference point, 16s delay	0.6	0.9	1.1	-1.0	-0.9	-1.1	1.0	0.7	0.7
Delay disc. indifference point, 2s delay	0.5	0.6	1.3	-0.5	-0.5	-0.6	0.5	1.1	1.0
Delay disc. indifference point, 24s delay	0.2	0.4	0.7	0.6	0.6	0.6	-0.6	-0.8	-0.6
Delay disc. indifference point, 4s delay	0.4	0.5	1.3	-0.3	-0.2	-0.4	0.4	1.0	1.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.4	-0.3	-0.3	-0.4	0.3	0.5	0.6
Indifference point function ln k	0.3	1.0	3.5	-0.1	0.1	-0.2	0.1	1.6	1.9
Indifference point function log k	0.3	1.0	3.5	-0.1	0.1	-0.2	0.1	1.6	1.9
Patch foraging total patch changes 0 sec	0.4	1.1	1.6	1.2	1.3	1.2	-1.2	-0.6	-0.5
Patch foraging total patch changes 12 sec	1.1	1.5	2.5	1.0	0.9	1.0	-1.0	-1.6	-1.6
Patch foraging total patch changes 18 sec	0.4	1.0	1.6	0.8	0.8	0.8	-0.8	-1.3	-1.3
Patch foraging total patch changes 24 sec	0.2	0.5	0.8	0.7	0.6	0.7	-0.7	-0.9	-0.7
Patch foraging total patch changes 6 sec	1.7	2.8	4.0	2.0	2.0	1.9	-2.0	-1.0	-0.7
Patch foraging time to switch 0 sec	0.5	1.8	4.4	0.8	0.6	1.0	-0.9	-1.9	-2.1
Patch foraging water rate 0 sec	0.3	1.1	2.4	-0.8	-0.6	-0.9	0.8	1.5	1.5
Patch foraging water rate 12 sec	0.0	0.2	0.6	0.2	0.3	0.1	-0.1	0.7	0.8
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.4	0.5	0.3	-0.3	-0.1	0.0
Patch foraging water rate 24 sec	0.3	0.4	0.7	0.6	0.8	0.6	-0.6	-0.7	-0.6
Patch foraging water rate 6 sec	0.4	0.6	1.6	-0.4	-0.2	-0.5	0.5	1.2	1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.3	-0.1	-0.0	-0.1	0.1	0.4	0.6
Distance traveled before self-admin	0.0	0.0	0.2	-0.1	-0.0	-0.1	0.1	-0.1	-0.5
Distance traveled after self-admin	0.1	0.2	0.6	0.2	0.3	0.3	-0.3	-0.5	-0.8
Extensor digitorum longus weight	0.2	0.8	1.2	-0.8	-0.8	-0.8	0.8	1.1	1.1
Bone: elastic displacement	5.4	6.9	7.6	-2.7	-2.8	-2.7	2.7	2.5	2.2
Bone: elastic work	3.2	4.2	5.1	-2.2	-2.2	-2.2	2.2	1.9	1.6
Bone: endosteal estimation	0.7	1.7	2.0	1.4	1.4	1.4	-1.4	-1.2	-1.0
Bone: endosteal perimeter	0.3	0.9	1.1	1.0	1.1	1.0	-1.0	-0.7	-0.5
Epididymis fat weight	0.5	2.4	3.6	1.8	1.9	1.8	-1.7	-1.0	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.0	-0.0	0.0	-0.0	0.5	0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.1	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	0.3	-0.6	-0.6	-0.5	0.5	0.1	-0.2
Delay discount exponential model param	0.6	0.8	1.4	0.8	0.7	0.8	-0.8	-1.1	-1.2
Extinction: sum of active levers before priming	0.1	0.1	0.2	0.4	0.4	0.3	-0.4	-0.3	-0.4
Active lever presses in extinction session 6	0.1	0.1	0.3	0.1	-0.0	0.2	-0.1	-0.5	-0.6
Bone: final force	0.8	1.3	1.4	1.2	1.2	1.2	-1.2	-1.2	-1.0
Bone: final moment	0.4	0.7	0.7	0.9	0.9	0.9	-0.9	-0.8	-0.7
Food consumed during 24 hour testing period	0.0	0.1	0.2	-0.4	-0.4	-0.3	0.3	0.2	0.1
Glucose	0.7	1.0	3.5	-0.4	-0.3	-0.4	0.4	1.5	1.9
Heart weight	16.0	25.8	29.2	-5.0	-4.9	-5.0	4.9	5.4	5.3
Delay discount hyperbolic model param	0.8	1.1	1.8	0.9	0.8	0.9	-0.9	-1.2	-1.4
Intermittent access intake day 1-15 change	0.1	0.4	0.8	-0.5	-0.5	-0.5	0.5	0.9	0.8
Intermittent access intake escalation	0.0	0.2	0.4	-0.3	-0.3	-0.3	0.3	0.6	0.5
Intermittent access intake escalation 2	0.5	0.8	1.3	-1.1	-1.0	-1.0	1.1	0.5	0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.3	0.3	0.3	-0.3	-0.1	-0.1
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.5	0.3	0.4	0.4	-0.3	-0.6	-0.7
Intermitt. access escalation Index	0.1	0.2	0.5	-0.6	-0.7	-0.5	0.5	-0.1	-0.1
Intermittent access day 1 total infusions	0.9	2.6	3.1	1.8	1.6	1.8	-1.8	-1.4	-1.3
Intermittent access day 15 total infusions	0.8	1.9	2.4	1.5	1.5	1.5	-1.6	-0.9	-0.9
Intermittent access terminal intake (last 3 days)	2.3	4.1	4.3	2.0	2.0	2.1	-2.1	-2.0	-2.0
Intermittent access total infusions	3.4	4.0	4.7	2.2	2.1	2.2	-2.2	-1.7	-1.6
Intermittent access day 1 locomotion	2.0	3.8	4.1	1.9	1.8	2.0	-1.9	-2.0	-1.9
Intermittent access day 15 total locomotion	0.3	1.1	1.7	0.9	0.9	0.9	-0.9	-1.1	-1.3
Intermittent access total locomotion	1.5	1.8	2.0	1.3	1.3	1.4	-1.3	-1.4	-1.4
Intermittent access standard deviation	0.0	0.1	0.2	0.2	0.2	0.2	-0.2	-0.5	-0.4
Left kidney weight	0.0	0.1	0.2	-0.4	-0.5	-0.4	0.4	0.1	0.3
Right kidney weight	0.1	0.4	0.9	-0.5	-0.6	-0.5	0.5	0.7	1.0
Cocaine induced anxiety	0.3	0.8	1.3	-1.1	-1.1	-1.0	1.0	0.2	-0.3
Post-drug Anxiety	0.3	0.4	0.6	-0.6	-0.6	-0.7	0.6	0.8	0.4
Baseline Anxiety	0.4	0.7	1.2	1.0	1.1	0.8	-0.9	0.4	0.6
Tail length	0.4	1.9	3.3	1.7	1.8	1.6	-1.6	-0.4	-0.4
Length with tail	0.5	2.1	3.2	1.7	1.8	1.7	-1.7	-0.6	-0.4
Length without tail	0.1	0.3	0.6	-0.5	-0.5	-0.5	0.5	0.6	0.8
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.2	0.3	-0.3	-0.4	-0.5
Lifetime Intake	3.1	3.8	4.1	2.0	1.9	2.0	-2.0	-1.9	-1.8
Liver weight, left	2.6	4.5	5.2	2.2	2.1	2.2	-2.2	-2.3	-1.9
Liver weight, right	2.6	4.6	5.7	2.4	2.3	2.3	-2.3	-1.8	-1.4
Locomotor activity	3.8	6.0	7.9	-2.8	-2.8	-2.7	2.7	1.8	1.5
Locomotor testing distance	1.1	2.7	4.0	-1.9	-2.0	-1.9	1.9	0.9	0.5
Locomotor testing rearing	0.2	0.6	1.7	0.3	0.2	0.3	-0.3	-1.2	-1.3
Locomotion in novel chamber	1.7	2.3	2.6	-1.5	-1.6	-1.4	1.4	1.5	1.6
Locomotion in novel chamber post-restriction	2.1	6.3	9.8	-2.2	-2.1	-2.2	2.2	3.1	3.1
Fecal boli incidents, locomotor time 1	0.5	1.3	1.7	1.3	1.3	1.3	-1.3	-0.8	-0.7
Change in fecal boli incidents, locomotor task	1.5	1.6	1.7	-1.3	-1.3	-1.3	1.3	1.3	1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.5	-0.4	-0.4	0.5	0.1	-0.0
Bouts of movement, locomotor time 1	1.4	1.8	2.1	1.4	1.4	1.4	-1.4	-1.2	-1.2
Total resting periods, locomotor time 1	2.3	2.7	2.8	1.7	1.7	1.7	-1.7	-1.7	-1.5
Rest time, locomotor task time 1	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.0	-0.2
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.1	-0.1	-0.0	0.0	0.5	0.4
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	0.3	0.1
Time >=10cm from walls, locomotor time 2	0.8	2.2	4.3	1.2	1.2	1.2	-1.2	-1.7	-2.1
Bouts of movement, locomotor time 2	0.0	0.1	0.2	0.4	0.4	0.3	-0.4	-0.4	-0.3
Total resting periods, locomotor time 2	0.0	0.0	0.0	0.1	0.2	0.1	-0.1	0.0	0.2
Rest time, locomotor task time 2	1.4	2.4	2.8	-1.6	-1.6	-1.7	1.7	1.2	1.4
Distance moved, locomotor task time 2	0.9	1.2	2.8	0.8	0.7	0.9	-0.9	-1.3	-1.7
Vertical activity count, locomotor time 2	0.2	0.5	1.9	0.0	-0.1	0.1	-0.1	-0.9	-1.4
Light reinforcement 1	0.0	0.1	0.3	-0.3	-0.3	-0.3	0.3	0.6	0.4
Light reinforcement 2	0.0	0.1	0.3	-0.1	-0.2	-0.0	0.1	-0.4	-0.5
Bone: marrow area	0.5	1.3	1.6	1.3	1.3	1.2	-1.2	-1.0	-0.8
Bone: maximum diameter	0.7	1.4	1.7	1.3	1.3	1.3	-1.2	-1.1	-0.8
Bone: maximum force	1.1	2.2	2.7	1.4	1.4	1.4	-1.4	-1.6	-1.5
Bone: maximum moment	0.6	1.0	1.3	0.9	0.9	1.0	-1.0	-1.1	-1.1
Mean time between licks in bursts	0.2	1.0	1.2	1.1	1.1	1.1	-1.1	-0.9	-0.6
Mean num. licks in bursts	0.8	2.2	3.1	1.7	1.8	1.7	-1.7	-1.0	-0.6
Cd content in liver	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.0	0.2	0.0
Co content in liver	0.4	0.5	0.7	-0.8	-0.8	-0.9	0.8	0.4	0.2
Cu content in liver	0.6	0.8	0.8	-0.8	-0.8	-0.9	0.9	0.9	0.9
Fe content in liver	0.2	0.3	0.4	0.6	0.6	0.5	-0.5	-0.6	-0.4
K content in liver	0.3	0.3	0.3	-0.6	-0.6	-0.6	0.6	0.5	0.5
Mg content in liver	0.1	0.1	0.1	0.4	0.4	0.4	-0.3	0.0	0.2
Mn content in liver	0.5	0.5	0.6	0.7	0.7	0.7	-0.7	-0.8	-0.7
Na content in liver	0.6	0.7	0.9	-0.9	-0.9	-0.9	1.0	0.6	0.6
Rb content in liver	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.1	-0.1
Se content in liver	2.0	2.3	2.6	1.6	1.6	1.6	-1.6	-1.4	-1.2
Sr content in liver	0.6	0.5	0.6	0.7	0.7	0.7	-0.7	-0.8	-0.7
Zn content in liver	0.2	0.3	0.7	0.3	0.4	0.3	-0.3	0.6	0.8
Bone: minimum diameter	2.0	3.9	4.1	2.0	2.0	2.0	-2.0	-1.9	-1.7
Time in familiar zone, hab. session 1	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.6	-0.3	-0.6
Time in novel zone, hab. session 1	0.2	0.3	0.4	0.6	0.6	0.6	-0.6	-0.0	0.2
Total zone transitions, hab. session 1	0.1	0.1	0.3	0.1	0.1	0.2	-0.2	-0.4	-0.5
Total locomotion distance, hab. session 1	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.4	0.6	0.5
Locomotion velocity, hab. session 1	0.4	0.6	1.1	-0.7	-0.7	-0.6	0.7	1.0	1.0
Time in familiar zone, hab. session 2	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.6	0.4	0.1
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.0	-0.1	-0.0	0.0	0.3	0.6
Total zone transitions, hab. session 2	0.9	1.1	1.3	-1.1	-1.1	-1.1	1.1	1.0	0.8
Total locomotion distance, hab. session 2	1.4	1.8	2.1	-1.4	-1.3	-1.4	1.4	1.4	1.2
Locomotion velocity, hab. session 2	0.8	1.1	1.1	-1.1	-1.0	-1.1	1.1	1.1	0.9
Novel to familiar place preference ratio	0.3	0.4	0.7	0.8	0.8	0.8	-0.8	-0.3	-0.1
Novelty place preference	0.2	0.3	0.5	0.7	0.7	0.7	-0.7	-0.1	0.2
Time in novel zone, NPP test	0.2	0.3	0.4	0.6	0.7	0.6	-0.6	0.1	0.3
Total zone transitions, NPP test	2.1	3.2	3.7	-1.8	-1.7	-1.8	1.8	1.9	1.7
Total locomotion distance, NPP test	1.9	2.7	3.1	-1.6	-1.6	-1.7	1.6	1.8	1.5
Locomotion velocity, NPP test	1.9	2.7	2.9	-1.7	-1.7	-1.7	1.7	1.7	1.4
Intraocular pressure	0.3	0.5	0.7	0.8	0.8	0.8	-0.8	-0.3	-0.3
Delta distance traveled before/after self-admin	0.1	0.2	0.4	0.2	0.2	0.3	-0.2	-0.7	-0.5
Delta ambulatory time before/after self-admin	0.4	0.7	1.6	0.5	0.5	0.7	-0.6	-1.3	-1.1
Parametrial fat weight	0.8	1.8	2.3	1.5	1.5	1.5	-1.5	-1.1	-0.9
Pavlov. Cond. lever latency	0.4	0.5	1.0	-0.5	-0.5	-0.5	0.5	1.0	0.9
Pavlov. Cond. magazine entry latency	1.2	1.5	2.2	1.4	1.5	1.4	-1.4	-0.9	-0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.3	0.4	0.4	0.4	-0.4	-0.5	-0.4
Pavlov. Cond. index score	1.3	1.7	2.0	1.4	1.4	1.4	-1.4	-1.2	-1.0
Pavlov. Cond. latency score	0.7	0.9	1.0	1.0	1.0	1.0	-1.0	-1.0	-0.9
Pavlov. Cond. lever contacts	0.7	0.8	1.0	0.9	0.9	0.9	-0.9	-1.0	-0.9
Pavlov. Cond. magazine entry number	1.0	1.3	2.0	-1.4	-1.4	-1.3	1.3	0.7	0.4
Pavlov. Cond. intertrial magazine entries	1.4	1.7	1.9	-1.4	-1.4	-1.4	1.4	1.2	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	2.4	1.5	1.6	1.5	-1.5	-1.4	-1.1
Pavlov. Cond. response bias	1.2	1.5	2.0	1.4	1.4	1.3	-1.3	-1.0	-0.7
Pavlov. Cond. lever latency	0.5	0.7	1.0	1.0	1.0	0.9	-1.0	-0.5	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.8	0.2	0.2	0.1	-0.1	0.6	0.9
Pavlov. Cond. change in total contacts	0.0	0.1	0.4	0.0	-0.0	0.0	-0.0	-0.4	-0.6
Pavlov. Cond. index score	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	-0.0	-0.1
Pavlov. Cond. lever contacts	0.5	0.7	1.0	-1.0	-1.0	-0.9	0.9	0.6	0.5
Pavlov. Cond. magazine entry number	0.3	0.3	1.0	0.2	0.2	0.3	-0.3	-0.9	-1.0
Pavlov. Cond. intertrial magazine entries	0.7	1.5	2.1	1.1	1.1	1.2	-1.1	-1.5	-1.4
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	-0.1	-0.2
Pavlov. Cond. response bias	0.7	1.0	1.1	-1.0	-0.9	-0.9	0.9	1.1	1.0
Time in closed arm before self-admin	0.2	0.3	0.5	0.7	0.7	0.6	-0.7	0.3	0.5
Time in closed arm after self-admin	0.5	0.6	1.1	0.7	0.7	0.6	-0.7	0.9	1.1
Time in open arm before self-admin	1.7	2.1	2.4	-1.5	-1.5	-1.5	1.5	1.4	1.2
Time in open arm after self-admin	1.5	1.7	2.5	-1.6	-1.5	-1.5	1.5	0.7	0.7
Bone: periosteal estimation	1.1	2.7	3.0	1.7	1.7	1.7	-1.7	-1.6	-1.4
Bone: periosteal perimeter	0.2	0.5	0.7	0.8	0.8	0.8	-0.8	-0.4	-0.1
Bone: post-yield work	1.0	1.6	2.3	1.5	1.5	1.4	-1.5	-0.8	-0.7
Progressive ratio test 1 active lever presses	0.5	0.9	1.2	1.1	1.1	1.0	-1.1	-0.7	-0.8
Progressive ratio test 1 breakpoint	0.6	1.0	1.3	1.1	1.1	1.0	-1.1	-0.8	-0.8
Progressive ratio test 1 inactive lever presses	0.2	0.5	0.8	0.9	0.9	0.8	-0.9	-0.3	-0.3
Progressive ratio test 2 active lever presses	2.8	3.9	4.1	2.0	2.0	2.0	-2.0	-1.9	-1.9
Progressive ratio test 2 breakpoint	3.2	4.1	4.2	2.0	2.0	2.0	-2.0	-2.0	-2.0
Progressive ratio test 2 inactive lever presses	0.5	1.5	1.7	1.3	1.3	1.3	-1.3	-1.0	-1.2
Incentive Sensitization - Responses	0.5	1.5	1.7	1.2	1.1	1.3	-1.3	-1.2	-1.2
Incentive Sensitization - Breakpoint	0.7	1.7	1.8	1.3	1.2	1.3	-1.3	-1.3	-1.3
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.2	0.2	0.2	0.3	-0.2	-0.8	-1.1
Progressive ratio	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1	-0.0
Food seeking constrained by brief footshock	1.3	1.7	2.8	-1.1	-1.1	-1.1	1.1	1.7	1.5
Seeking ratio, punishment vs. effort	0.4	0.8	1.8	-0.5	-0.5	-0.6	0.6	1.3	1.3
Retroperitoneal fat weight	0.2	0.9	1.7	0.9	0.8	0.9	-0.9	-1.3	-1.0
Reaction time number correct	0.4	1.5	3.3	-0.8	-0.7	-0.9	0.8	1.8	1.8
Reaction time mean minus median	0.1	0.9	1.4	1.2	1.1	1.1	-1.2	-0.3	-0.0
Reaction time mean minus median AUC	0.0	0.0	0.1	0.3	0.0	0.3	-0.3	-0.0	-0.0
Reaction time num false alarms	0.3	0.4	0.8	0.8	0.9	0.8	-0.8	-0.0	0.1
Reaction time num false alarms AUC	0.1	0.2	0.6	0.1	0.2	0.1	-0.2	0.6	0.8
Reaction time trials correct on left	0.4	1.5	3.3	-0.8	-0.7	-0.9	0.8	1.8	1.8
Reaction time trials on left	0.4	1.4	3.1	-0.8	-0.7	-0.8	0.8	1.8	1.7
Reaction time mean	0.1	0.3	0.5	0.6	0.7	0.5	-0.5	0.4	0.6
Reaction time mean AUC	0.1	0.3	0.5	0.6	0.7	0.5	-0.6	0.2	0.3
Median of all reaction times	0.1	0.2	0.3	0.3	0.5	0.2	-0.3	0.5	0.6
Reaction time omissions	0.2	0.4	0.5	0.6	0.7	0.7	-0.6	-0.6	-0.4
Reaction time false alarm rate	0.2	0.3	0.4	0.6	0.7	0.6	-0.6	-0.4	-0.3
Reaction time premature initiation rate	1.9	3.0	5.4	1.5	1.4	1.5	-1.4	-2.3	-2.1
Reaction time premature initiations	0.3	0.9	1.2	1.0	0.9	0.9	-0.9	-1.1	-0.9
Std. dev. reaction times	0.3	0.9	1.3	1.1	1.1	1.1	-1.1	-0.4	-0.2
Reaction time trials completed	0.4	1.4	3.1	-0.8	-0.7	-0.8	0.8	1.8	1.7
Reaction time trials AUC	0.5	1.6	3.8	-0.7	-0.6	-0.8	0.7	1.9	1.9
Run reversals in cocaine runway, females	0.8	0.9	1.4	-1.1	-1.2	-1.1	1.1	0.4	0.2
Run reversals in cocaine runway, males	0.7	0.8	1.1	-0.9	-0.8	-0.9	0.9	0.9	1.0
Latency to leave start box in cocaine runway	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.2	0.2	0.3
Latency to leave start box in cocaine runway, F	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	0.1	0.2
Latency to leave start box in cocaine runway, M	0.8	0.8	1.1	-1.0	-1.1	-1.0	1.0	0.6	0.5
Std. dev. time between licks in bursts	0.6	1.1	1.7	-1.3	-1.3	-1.2	1.3	0.2	-0.1
Total sessions with >9 infusions	0.5	0.6	0.7	0.8	0.7	0.8	-0.8	-0.8	-0.6
Short access day 1 total inactive lever presses	0.1	0.2	0.3	0.4	0.4	0.5	-0.5	-0.5	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.4	-0.4	-0.4	0.4	0.4	0.2
Short access day 1 total infusions	0.6	1.1	1.4	1.1	1.1	1.2	-1.2	-0.8	-0.8
Short access day 10 total infusions	0.5	0.9	1.1	1.0	0.9	1.0	-1.0	-0.9	-0.7
Short access total infusions	1.2	1.7	2.1	1.2	1.1	1.3	-1.3	-1.5	-1.4
Short access day 1 locomotion	0.1	0.2	0.3	0.5	0.3	0.4	-0.5	-0.5	-0.6
Short access day 10 total locomotion	0.0	0.2	0.3	-0.5	-0.5	-0.5	0.5	0.3	0.4
Short access total locomotion	0.1	0.1	0.2	0.1	0.0	0.1	-0.1	-0.5	-0.5
One hour access (0.3 mA shock)	0.9	1.0	1.4	0.9	0.9	1.1	-1.0	-1.2	-1.1
Compulsive drug intake	0.4	0.5	1.2	-0.9	-1.1	-0.7	0.8	-0.1	-0.1
One hour access (shock baseline)	0.5	1.2	1.7	1.3	1.3	1.2	-1.3	-0.6	-0.5
Social response proportion	1.1	1.4	2.3	1.0	0.9	1.1	-1.0	-1.5	-1.5
Social responses	0.3	0.3	1.2	-0.1	-0.3	0.0	0.0	-0.8	-1.1
Social time	0.8	1.2	1.4	-1.2	-1.2	-1.2	1.2	1.0	0.9
Soleus weight	0.2	0.5	0.6	-0.7	-0.7	-0.7	0.7	0.8	0.7
Bone: stiffness	2.8	5.0	5.6	2.2	2.2	2.3	-2.2	-2.4	-2.1
Tibialis anterior weight	0.0	0.2	0.3	0.5	0.5	0.5	-0.5	-0.1	0.1
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.0	-1.0	-0.9	-0.9	1.0	0.9	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.7	-0.5	-0.5	-0.4	0.5	-0.7	-0.8
Time to tail flick, test, before self-admin	1.8	2.1	2.7	-1.6	-1.7	-1.6	1.6	1.0	0.9
Time to tail flick, test, after self-admin	3.4	3.6	4.8	-2.2	-2.2	-2.1	2.1	1.3	1.3
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.8	0.5	0.4	0.5	-0.5	-1.3	-1.3
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.3	0.4	0.5
Tibia length	2.0	5.7	6.0	2.4	2.4	2.5	-2.5	-2.4	-2.1
Ambulatory time before self-admin	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.2	0.1	-0.3
Ambulatory time after self-admin	0.3	0.6	1.4	0.5	0.5	0.5	-0.5	-0.9	-1.2
Bone: tissue strength	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2	-0.0	-0.1
Total heroin consumption	0.5	0.6	1.8	-0.5	-0.5	-0.5	0.5	1.1	1.3
Bone: trabecular number	0.0	0.1	0.1	-0.3	-0.4	-0.3	0.3	0.2	0.0
Bone: trabecular spacing	0.1	0.2	0.3	-0.3	-0.3	-0.3	0.3	0.6	0.6
Bone: trabecular thickness	0.1	0.2	0.3	-0.3	-0.3	-0.3	0.3	0.6	0.5
Bone: trabecular tissue density	0.2	0.4	0.7	0.5	0.6	0.5	-0.5	-0.8	-0.9
Water consumed over 24 hours	0.1	0.1	0.3	-0.2	-0.2	-0.2	0.2	0.5	0.5
Number of responses in last shaping day	0.1	0.1	0.4	-0.2	-0.1	-0.3	0.2	0.7	0.4