Hub : Genes

Castor1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Castor1	0.09	0.04	7.0e-09	0.07	0.06	0.05	0.06	1.1e-08	3.3e-07	5.6e-06	1.9e-07
2	pVTA	intron excision ratio	chr14_83309880_83310405	0.04	0.03	9.3e-03	0.02	0.03	0.02	0.03	8.6e-03	3.5e-03	4.9e-03	3.9e-03
3	NAcc	gene expression	Castor1	0.05	0.03	9.3e-06	0.03	0.04	0.03	0.03	1.2e-05	7.5e-07	1.8e-05	1.6e-05
4	BLA	gene expression	Castor1	0.18	0.12	8.2e-03	0.04	0.02	0.04	0.04	3.5e-03	2.1e-02	2.7e-03	4.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.3	0.6	1.1	1.0	-0.6	-0.7	-0.7
Area under the delay curve	5.1	7.8	10.7	-3.3	3.2	3.0	-1.2
BMI with tail	0.5	1.6	3.0	-0.8	1.7	1.0	1.3
BMI without tail	0.1	0.6	1.2	-0.5	0.9	0.1	1.1
Body weight	1.7	7.5	15.5	-2.8	3.9	2.6	-0.1
Weight adjusted by age	0.5	1.5	1.8	-1.2	1.3	1.2	-1.2
Bone surface	0.0	0.1	0.1	-0.2	0.4	0.3	-0.2
Bone volume	0.0	0.0	0.0	0.1	0.2	0.0	-0.2
Breakpoint value in progressive ratio session	0.2	0.4	1.0	-0.3	0.6	0.4	-1.0
Number of licking bursts	0.3	0.9	1.9	-1.2	1.4	0.5	0.3
Context. condit. distance diff. score	1.7	2.0	3.0	1.7	-1.4	-1.7	0.4
Locomotion velocity, session 1	0.4	0.4	1.3	0.3	-1.1	0.3	-0.3
Locomotion distance, session 1	1.2	1.5	2.9	1.7	-1.3	-1.0	-0.7
Locomotion velocity, session 2	0.8	1.0	2.7	0.6	-1.6	0.3	-0.9
Locomotion distance, session 2	2.1	2.9	5.2	2.0	-2.3	-1.4	0.8
Locomotion velocity, session 3	1.2	1.4	4.0	2.0	-0.9	-0.8	0.1
Locomotion distance, session 3	0.2	0.2	0.7	0.0	-0.0	0.9	0.4
Stereotopy head waving bouts, day 3	1.4	1.7	3.3	1.8	-1.4	-1.1	0.3
Stereotopy head waving duration, day 3	2.6	3.2	5.1	2.3	-1.8	-1.7	1.3
Locomotion velocity, session 7	0.1	0.1	0.3	0.1	-0.4	0.5	-0.3
Locomotion distance, session 7	0.4	0.6	1.2	1.1	-0.9	-0.4	0.4
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	-0.3	0.7	0.4	0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.3	0.7	0.2	0.5
Locomotion velocity, session 8	2.4	2.9	4.8	1.0	-2.1	-1.2	2.2
Locomotion distance, session 8	6.3	9.1	12.5	3.5	-3.3	-3.3	1.4
Degree of sensitization distance	2.6	2.8	4.5	1.7	-1.8	-2.1	0.6
Degree of sensitization stereotypy	0.4	0.5	1.1	-0.7	1.0	0.4	-0.0
Conditioned locomotion	0.5	0.5	1.2	1.1	0.1	-0.8	0.5
Cocaine response after cond. corrected	0.8	1.2	1.6	-0.8	1.2	1.3	-1.0
Cocaine response after cond. not corrected	2.1	3.1	4.7	-0.8	1.9	1.7	-2.2
Cocaine response before conditioning	0.9	1.1	3.6	0.5	0.5	0.3	-1.9
Saline control response	0.7	1.0	2.4	1.2	-1.5	-0.4	-0.5
Bone: connectivity density	0.3	0.5	1.2	1.1	-0.4	-0.5	-0.6
Bone: cortical apparent density	0.5	0.8	1.9	-0.9	0.6	-0.3	1.4
Bone: cortical area	2.0	3.2	5.4	-1.8	2.3	1.5	-1.3
Bone: cortical porosity	1.0	1.1	3.4	0.4	0.5	0.8	-1.8
Bone: cortical porosity	0.4	0.4	1.1	0.7	0.3	0.2	-1.1
Bone: cortical thickness	1.5	2.4	5.6	-1.5	2.4	1.0	-0.9
Bone: cortical thickness	0.4	0.5	1.0	1.0	0.2	-1.0	-0.2
Bone: cortical tissue density	0.6	0.9	2.1	-1.0	0.7	-0.2	1.5
Condit. Reinf. active minus inactive responses	0.2	0.2	0.4	-0.2	-0.3	0.7	0.4
Condit. Reinf. active-inactive response ratio	0.9	0.9	1.9	0.1	-1.3	0.2	1.4
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	-0.4	0.2	0.3
Condit. Reinf. inactive responses	0.3	0.4	0.9	0.1	0.8	-0.1	-0.9
Incentive salience index mean	0.3	0.4	1.2	-0.5	0.3	1.1	-0.1
Condit. Reinf. lever presses	0.3	0.5	0.9	-0.2	1.0	0.9	-0.5
Condit. Reinf. active minus inactive responses	0.8	1.3	1.6	1.3	-1.2	-0.9	-1.1
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.1	0.2	-0.1	0.2	-1.1
Condit. Reinf. active responses	1.6	2.3	4.2	1.7	-2.1	-1.2	-0.8
Condit. Reinf. inactive responses	1.6	2.4	4.3	1.6	-2.1	-1.5	0.6
Condit. Reinf. lever presses	0.4	0.6	1.0	1.0	-0.9	-0.7	-0.3
Condit. Reinf. lever reinforcers received	1.3	1.8	3.1	1.5	-1.8	-1.0	-0.9
Conditioned reinforcement - actives	0.5	1.9	2.9	-1.4	1.7	1.6	-0.7
Conditioned reinforcement - inactives	1.3	3.6	5.6	-2.4	1.7	2.3	-0.8
Conditioned locomotion	1.1	1.7	2.7	-1.4	1.6	1.4	-0.2
Patch foraging indifference point 0 sec	0.1	0.2	0.6	-0.8	0.3	0.0	-0.1
Patch foraging indifference point AUC	0.3	0.8	2.3	0.7	-1.5	0.1	-0.6
Delay disc. indifference point, 0s delay	4.8	5.4	11.4	-2.4	3.4	2.1	-0.4
Delay disc. indifference point, 16s delay	3.6	5.2	8.8	-3.0	2.3	2.4	-0.8
Delay disc. indifference point, 2s delay	5.2	5.8	8.3	-2.4	2.9	2.4	-1.9
Delay disc. indifference point, 24s delay	2.6	4.2	6.5	-2.1	2.6	2.3	-0.7
Delay disc. indifference point, 4s delay	4.2	4.4	5.6	-2.1	2.1	2.4	-1.9
Delay disc. indifference point, 8s delay	0.9	1.5	3.1	-1.8	1.0	1.4	0.2
Indifference point function ln k	0.2	0.6	2.0	0.4	0.5	-0.0	-1.4
Indifference point function log k	0.2	0.6	2.0	0.4	0.5	-0.0	-1.4
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.7	0.3	0.2	-0.2
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.0	0.5	-0.0	-0.2
Patch foraging total patch changes 18 sec	0.2	0.5	0.7	-0.9	-0.2	0.8	0.7
Patch foraging total patch changes 24 sec	1.0	3.3	4.0	1.5	-1.9	-1.8	2.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.5	-0.6	-0.2	0.5	-0.7
Patch foraging time to switch 0 sec	1.2	4.6	15.5	-0.3	1.0	-1.4	3.9
Patch foraging water rate 0 sec	0.6	2.1	6.2	-0.3	-0.2	1.5	-2.5
Patch foraging water rate 12 sec	0.3	1.2	2.5	1.2	-0.9	0.3	-1.6
Patch foraging water rate 18 sec	0.7	1.6	2.3	1.5	-0.6	-1.3	-1.5
Patch foraging water rate 24 sec	0.4	0.6	0.8	0.9	-0.9	-0.2	-0.7
Patch foraging water rate 6 sec	0.6	0.9	2.7	0.9	-0.6	0.0	-1.6
Seeking ratio, delayed vs. immediate footshock	1.2	1.7	5.3	0.0	-1.1	0.4	-2.3
Distance traveled before self-admin	0.1	0.3	0.7	-0.4	-0.6	0.0	-0.8
Distance traveled after self-admin	0.1	0.2	0.7	-0.5	0.1	0.2	-0.8
Extensor digitorum longus weight	2.2	8.6	11.0	-2.7	3.3	3.0	-2.7
Bone: elastic displacement	0.4	0.5	1.3	-0.1	-0.1	-0.9	1.1
Bone: elastic work	0.2	0.3	0.5	-0.3	0.7	-0.5	0.4
Bone: endosteal estimation	0.0	0.1	0.3	-0.0	-0.2	-0.1	-0.6
Bone: endosteal perimeter	0.5	1.2	1.7	-1.2	0.6	1.0	-1.3
Epididymis fat weight	0.5	2.6	7.3	-1.4	2.7	1.0	0.4
Delta time in closed arm before/after self-admin	3.3	3.1	6.0	2.5	-1.0	-1.9	-1.3
Delta time in open arm before/after self-admin	4.3	5.0	9.8	-3.1	1.7	2.1	1.8
Diff in mean of infusions in LGA sessions	0.0	0.1	0.1	-0.3	-0.2	-0.1	0.4
Delay discount exponential model param	5.4	7.3	9.6	3.1	-3.0	-2.9	1.2
Extinction: sum of active levers before priming	0.8	1.3	1.9	-1.2	1.1	1.4	-0.7
Active lever presses in extinction session 6	1.0	1.0	1.8	-0.3	1.4	0.8	-1.1
Bone: final force	0.4	0.6	1.4	-0.7	0.6	-0.2	1.2
Bone: final moment	0.3	0.4	0.7	-0.9	0.7	-0.1	0.6
Food consumed during 24 hour testing period	0.2	0.3	0.6	-0.5	-0.8	0.5	-0.5
Glucose	9.3	14.8	29.2	-5.2	1.6	5.4	0.2
Heart weight	0.4	0.6	1.1	-0.6	0.9	1.0	-0.5
Delay discount hyperbolic model param	5.8	7.5	9.6	3.1	-3.1	-3.0	1.4
Intermittent access intake day 1-15 change	0.2	0.9	1.6	-1.2	0.8	1.3	-0.0
Intermittent access intake escalation	0.2	1.3	2.4	-1.2	1.1	1.5	-0.6
Intermittent access intake escalation 2	0.2	0.3	0.6	-0.8	0.5	0.6	0.4
Intermitt. access day 1 inactive lever presses	0.1	1.1	3.1	0.2	0.5	1.0	-1.8
Intermitt. access day 15 inactive lever presses	0.2	1.2	3.2	-1.1	0.3	1.8	-0.6
Intermitt. access escalation Index	0.2	0.6	1.3	0.5	-0.7	-0.7	1.1
Intermittent access day 1 total infusions	0.6	1.9	3.1	-1.8	1.7	1.2	-0.2
Intermittent access day 15 total infusions	1.6	4.0	6.1	-2.5	2.1	2.2	-0.8
Intermittent access terminal intake (last 3 days)	1.4	2.5	4.1	-2.0	1.5	1.7	-0.7
Intermittent access total infusions	2.5	3.0	4.7	-2.2	1.7	1.9	-0.9
Intermittent access day 1 locomotion	0.0	0.1	0.2	0.0	-0.4	-0.1	-0.1
Intermittent access day 15 total locomotion	0.9	3.4	5.5	-2.2	2.3	1.9	0.1
Intermittent access total locomotion	1.7	2.1	3.3	-1.6	1.2	1.8	-0.9
Intermittent access standard deviation	0.0	0.0	0.1	-0.1	0.0	0.2	-0.0
Left kidney weight	0.1	1.0	2.5	0.8	1.6	-0.4	-0.9
Right kidney weight	0.2	1.6	4.4	0.9	2.1	-0.6	-0.9
Cocaine induced anxiety	0.7	1.8	3.4	-1.3	0.8	1.9	-1.2
Post-drug Anxiety	2.0	2.3	3.1	-1.4	1.5	1.8	-1.4
Baseline Anxiety	0.3	0.5	1.1	-0.4	1.1	-0.1	0.9
Tail length	0.6	3.1	4.2	-1.7	1.7	1.6	-2.1
Length with tail	1.1	5.1	7.5	-2.1	2.7	1.9	-2.2
Length without tail	0.6	2.9	6.5	-1.4	2.5	1.4	-1.2
Times rat made contact with spout	0.5	0.6	2.3	-0.2	-1.5	0.3	0.4
Lifetime Intake	2.4	3.0	4.6	-2.1	1.5	1.9	-1.3
Liver weight, left	0.5	0.9	1.9	1.4	-0.1	-0.8	-1.1
Liver weight, right	0.8	1.5	2.3	1.5	-0.4	-1.5	1.0
Locomotor activity	0.3	0.4	1.1	-0.5	-0.6	1.1	-0.2
Locomotor testing distance	0.3	0.7	1.0	-0.3	0.8	0.9	-1.0
Locomotor testing rearing	0.6	2.0	3.5	-1.4	1.1	1.9	-1.2
Locomotion in novel chamber	0.5	0.6	1.4	1.2	-0.3	-0.7	-0.6
Locomotion in novel chamber post-restriction	0.5	1.6	2.8	1.2	-1.7	-1.0	1.0
Fecal boli incidents, locomotor time 1	0.2	0.4	0.8	0.4	-0.9	-0.1	-0.8
Change in fecal boli incidents, locomotor task	1.2	1.2	3.3	0.4	-1.2	-0.2	1.8
Time >=10cm from walls, locomotor time 1	1.8	2.3	7.6	-0.4	0.8	-0.8	2.8
Bouts of movement, locomotor time 1	0.9	1.2	4.0	-0.6	0.5	0.4	2.0
Total resting periods, locomotor time 1	1.2	1.3	4.4	-0.7	0.4	0.6	2.1
Rest time, locomotor task time 1	0.1	0.2	0.5	0.2	-0.7	0.2	0.4
Distance moved, locomotor task time 1	0.0	0.1	0.2	-0.4	0.3	-0.4	-0.3
Vertical activity count, locomotor time 1	0.0	0.2	0.4	-0.4	-0.4	-0.4	-0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.2	-0.2	-0.5	0.1
Bouts of movement, locomotor time 2	0.2	0.5	1.7	0.5	0.4	0.3	-1.3
Total resting periods, locomotor time 2	0.1	0.4	1.2	0.4	0.3	0.4	-1.1
Rest time, locomotor task time 2	0.4	0.6	1.0	0.5	-1.0	-0.5	0.9
Distance moved, locomotor task time 2	0.1	0.1	0.2	-0.1	0.3	-0.4	0.4
Vertical activity count, locomotor time 2	0.2	0.5	1.5	-0.4	0.4	0.2	-1.2
Light reinforcement 1	0.1	0.4	0.9	0.2	0.9	0.4	-0.6
Light reinforcement 2	0.1	0.2	0.5	0.3	0.2	-0.7	0.4
Bone: marrow area	0.0	0.1	0.3	0.0	-0.3	-0.1	-0.5
Bone: maximum diameter	2.4	4.9	7.4	-2.7	2.1	2.3	-1.5
Bone: maximum force	0.2	0.3	0.4	-0.6	0.5	-0.5	0.6
Bone: maximum moment	0.1	0.2	0.5	-0.7	0.5	-0.4	-0.0
Mean time between licks in bursts	0.1	0.5	1.9	-0.0	-1.4	0.2	0.1
Mean num. licks in bursts	0.6	1.6	5.2	1.0	-2.3	-0.3	-0.0
Cd content in liver	0.3	0.4	0.7	-0.8	0.2	0.7	0.5
Co content in liver	0.4	0.5	0.8	-0.5	0.8	0.9	-0.5
Cu content in liver	0.2	0.2	0.3	-0.4	0.6	0.5	-0.4
Fe content in liver	0.6	0.7	1.5	1.0	-1.2	-0.5	-0.0
K content in liver	3.7	3.6	7.0	-1.4	2.6	1.8	-1.5
Mg content in liver	3.1	3.4	6.7	-1.3	2.6	1.8	-1.4
Mn content in liver	0.2	0.2	0.5	0.1	0.2	0.4	-0.7
Na content in liver	4.7	5.3	8.1	-2.5	1.9	2.8	-1.8
Rb content in liver	0.6	0.7	1.3	-1.1	1.0	0.6	-0.3
Se content in liver	3.3	3.9	5.5	-1.4	2.2	1.8	-2.4
Sr content in liver	2.1	1.8	4.4	-2.1	1.0	1.4	0.2
Zn content in liver	0.1	0.2	0.4	0.1	0.4	0.2	-0.6
Bone: minimum diameter	0.2	0.4	1.3	0.4	-0.2	-0.4	-1.1
Time in familiar zone, hab. session 1	1.5	1.7	2.9	0.1	-1.3	-1.4	1.7
Time in novel zone, hab. session 1	1.0	1.2	2.4	-0.3	1.1	1.0	-1.5
Total zone transitions, hab. session 1	0.6	0.8	2.5	0.3	-1.6	-0.6	0.4
Total locomotion distance, hab. session 1	0.3	0.4	0.7	0.1	-0.8	0.4	-0.8
Locomotion velocity, hab. session 1	0.2	0.3	0.7	0.4	-0.8	0.3	-0.4
Time in familiar zone, hab. session 2	2.6	2.9	4.5	1.2	-1.4	-2.1	2.0
Time in novel zone, hab. session 2	1.3	1.5	2.4	-1.1	1.1	1.5	-1.1
Total zone transitions, hab. session 2	0.1	0.1	0.3	-0.1	-0.6	0.4	0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.6	-0.6	-0.3	0.8	0.1
Locomotion velocity, hab. session 2	0.3	0.4	1.2	-0.7	0.1	1.1	-0.3
Novel to familiar place preference ratio	1.0	1.4	3.3	-1.2	0.6	1.8	-0.7
Novelty place preference	1.1	1.4	3.2	-1.1	0.6	1.8	-0.9
Time in novel zone, NPP test	1.0	1.2	2.7	-1.1	0.4	1.6	-0.9
Total zone transitions, NPP test	0.2	0.4	0.8	0.7	-0.1	-0.4	-0.9
Total locomotion distance, NPP test	0.2	0.3	0.8	0.3	0.1	0.2	-0.9
Locomotion velocity, NPP test	0.3	0.4	1.3	0.1	0.5	0.5	-1.1
Intraocular pressure	1.3	2.1	7.2	-0.5	-1.0	0.0	2.7
Delta distance traveled before/after self-admin	0.3	0.4	0.8	-0.1	0.9	0.2	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.6	0.4	0.4	-0.1	0.8
Parametrial fat weight	1.6	3.9	6.1	-2.2	-0.2	2.1	2.5
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.8	0.1	0.7	-0.5
Pavlov. Cond. magazine entry latency	1.4	1.8	3.1	1.6	-1.8	-1.2	0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.8	-0.4	0.2	0.9	0.1
Pavlov. Cond. index score	1.1	1.4	2.7	1.6	-1.2	-1.2	0.5
Pavlov. Cond. latency score	1.1	1.4	2.4	1.5	-1.1	-1.3	0.7
Pavlov. Cond. lever contacts	0.7	0.8	1.7	1.3	-0.5	-0.9	0.7
Pavlov. Cond. magazine entry number	1.4	1.8	3.2	-1.8	1.8	0.8	0.0
Pavlov. Cond. intertrial magazine entries	1.4	1.6	4.4	-0.3	1.4	0.4	-2.1
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.5	3.1	1.8	-1.1	-1.3	0.4
Pavlov. Cond. response bias	0.5	0.6	1.5	1.2	-0.6	-0.3	-0.5
Pavlov. Cond. lever latency	1.7	2.4	5.2	-1.6	2.3	1.3	-0.5
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.3	-0.1	-0.1	-0.4
Pavlov. Cond. change in total contacts	0.3	0.8	1.8	0.6	-1.3	-1.0	0.4
Pavlov. Cond. index score	0.6	0.9	1.9	0.9	-1.4	-0.9	0.1
Pavlov. Cond. latency score	0.7	1.1	2.2	1.0	-1.5	-1.0	-0.1
Pavlov. Cond. lever contacts	1.7	2.5	5.0	1.7	-2.2	-1.3	0.2
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.6	0.4	0.4	-0.2
Pavlov. Cond. intertrial magazine entries	0.1	0.3	0.6	0.8	0.1	0.3	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	2.1	0.9	-1.4	-1.1	0.2
Pavlov. Cond. response bias	0.8	1.1	2.3	1.0	-1.5	-1.0	0.3
Time in closed arm before self-admin	0.3	0.6	1.1	0.7	-0.3	-1.1	0.7
Time in closed arm after self-admin	2.1	2.4	4.9	2.2	-0.6	-2.0	-0.4
Time in open arm before self-admin	0.3	0.4	1.3	0.4	0.0	0.1	-1.1
Time in open arm after self-admin	1.5	1.7	3.3	-1.8	0.6	1.3	1.2
Bone: periosteal estimation	0.4	0.9	1.2	-1.0	1.1	0.6	-1.1
Bone: periosteal perimeter	1.4	2.8	3.6	-1.7	1.9	1.6	-1.6
Bone: post-yield work	0.1	0.2	0.4	-0.6	-0.3	-0.1	-0.6
Progressive ratio test 1 active lever presses	1.9	3.4	4.2	-1.8	1.4	2.0	-2.1
Progressive ratio test 1 breakpoint	2.0	3.4	4.2	-1.8	1.5	2.0	-2.0
Progressive ratio test 1 inactive lever presses	1.8	4.8	7.3	-2.7	1.5	2.5	-1.8
Progressive ratio test 2 active lever presses	1.6	2.3	4.5	-2.1	1.4	1.5	0.6
Progressive ratio test 2 breakpoint	1.6	2.1	4.0	-2.0	1.3	1.4	0.8
Progressive ratio test 2 inactive lever presses	1.3	4.1	6.1	-2.5	1.9	2.1	1.5
Incentive Sensitization - Responses	1.0	2.7	6.8	-1.7	1.0	0.5	2.6
Incentive Sensitization - Breakpoint	1.2	2.7	7.2	-1.6	0.9	0.4	2.7
Sum of active levers in priming session hrs 5-6	1.0	1.0	2.2	-0.7	1.5	0.7	-0.9
Progressive ratio	0.2	0.7	1.7	-0.9	0.2	-0.1	1.3
Food seeking constrained by brief footshock	1.9	2.4	3.8	-2.0	1.8	1.4	-0.9
Seeking ratio, punishment vs. effort	0.7	1.6	5.1	0.3	0.6	0.9	-2.3
Retroperitoneal fat weight	0.8	3.8	12.0	-1.4	0.2	1.1	3.5
Reaction time number correct	0.2	0.7	2.1	0.7	-1.5	-0.4	0.2
Reaction time mean minus median	0.0	0.1	0.2	-0.4	0.3	0.4	-0.4
Reaction time mean minus median AUC	0.1	0.4	0.9	-0.5	0.9	0.5	-0.3
Reaction time num false alarms	0.4	0.8	2.0	-0.9	1.4	0.5	-0.3
Reaction time num false alarms AUC	0.3	0.6	1.9	-0.7	1.4	0.1	-0.1
Reaction time trials correct on left	0.2	0.7	2.1	0.7	-1.5	-0.4	0.2
Reaction time trials on left	0.2	0.7	2.2	0.7	-1.5	-0.4	0.2
Reaction time mean	0.1	0.1	0.4	-0.1	0.6	-0.1	0.2
Reaction time mean AUC	0.0	0.1	0.3	0.1	0.6	-0.2	0.0
Median of all reaction times	0.1	0.2	0.3	0.1	0.6	-0.3	0.5
Reaction time omissions	0.2	0.3	0.7	0.8	-0.6	-0.3	0.4
Reaction time false alarm rate	1.0	1.4	4.5	-1.0	2.1	0.4	-0.3
Reaction time premature initiation rate	2.6	4.0	7.6	2.8	-1.9	-2.2	0.0
Reaction time premature initiations	1.3	3.9	6.5	2.6	-2.3	-2.0	0.0
Std. dev. reaction times	0.1	0.3	0.7	-0.6	0.5	0.2	0.8
Reaction time trials completed	0.2	0.7	2.2	0.7	-1.5	-0.4	0.2
Reaction time trials AUC	0.2	0.6	1.8	0.7	-1.3	-0.3	-0.0
Run reversals in cocaine runway, females	1.5	1.7	6.2	0.0	0.1	-0.6	2.5
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.3	-0.1	0.1	-0.3
Latency to leave start box in cocaine runway	0.2	0.3	0.8	-0.3	0.0	0.4	-0.9
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.6	0.6	0.3	-0.4
Latency to leave start box in cocaine runway, M	0.8	0.7	2.0	0.1	-0.6	0.7	-1.4
Std. dev. time between licks in bursts	0.4	0.8	2.0	0.8	-1.4	-0.7	0.1
Total sessions with >9 infusions	0.6	0.8	2.7	0.4	-0.5	0.0	-1.6
Short access day 1 total inactive lever presses	1.2	2.3	4.7	-2.2	0.9	1.8	-0.8
Short access day 10 total inactive lever presses	0.1	0.9	2.6	0.7	-0.4	0.5	-1.6
Short access day 1 total infusions	0.1	0.2	0.8	0.1	0.0	-0.0	-0.9
Short access day 10 total infusions	0.0	0.1	0.2	-0.1	-0.4	0.0	-0.2
Short access total infusions	0.3	0.4	0.7	-0.8	0.1	0.6	-0.8
Short access day 1 locomotion	0.5	0.9	1.3	0.9	-1.1	-1.0	-0.7
Short access day 10 total locomotion	0.7	2.8	6.3	1.7	-2.5	-1.2	-0.8
Short access total locomotion	2.2	3.4	6.5	2.0	-2.5	-1.3	-1.1
One hour access (0.3 mA shock)	1.7	2.0	4.3	-2.1	1.0	1.5	-0.6
Compulsive drug intake	1.2	1.8	3.3	1.8	-1.1	-1.7	-0.0
One hour access (shock baseline)	1.9	4.9	8.0	-2.8	1.9	2.6	-0.9
Social response proportion	1.1	1.4	4.4	-0.8	-0.6	0.2	2.1
Social responses	0.6	0.8	2.3	-0.8	-0.4	0.5	1.5
Social time	1.0	1.6	4.8	0.3	-0.9	-0.8	2.2
Soleus weight	0.5	1.4	2.8	-0.7	1.3	0.7	-1.7
Bone: stiffness	0.1	0.2	0.4	0.7	0.2	-0.4	0.1
Tibialis anterior weight	1.2	4.2	4.7	-2.1	2.2	2.1	-1.8
Time to tail flick, vehicle, before self-admin	1.1	1.3	4.6	-0.2	0.6	-0.6	2.1
Time to tail flick, vehicle, after self-admin	0.2	0.4	1.3	0.4	-0.4	-0.0	1.1
Time to tail flick, test, before self-admin	1.0	1.2	2.1	1.4	-0.8	-0.2	-1.4
Time to tail flick, test, after self-admin	0.7	0.7	1.4	-0.8	0.5	1.2	-0.8
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	0.3	-0.9	0.4	-0.5
Delta time to tail flick, test, before/after SA	0.8	0.9	2.2	-1.5	0.7	0.9	0.6
Tibia length	0.3	0.8	1.7	1.0	0.6	-1.3	-0.3
Ambulatory time before self-admin	0.1	0.3	0.6	-0.8	-0.2	0.2	-0.8
Ambulatory time after self-admin	0.1	0.1	0.4	-0.3	-0.1	0.0	-0.6
Bone: tissue strength	0.7	0.7	1.3	-0.0	-0.6	-1.0	1.2
Total heroin consumption	0.1	0.2	0.4	0.5	-0.2	-0.6	0.1
Bone: trabecular number	0.2	0.3	0.6	0.8	0.1	-0.4	-0.7
Bone: trabecular spacing	0.9	1.3	3.5	-1.9	0.1	0.7	1.0
Bone: trabecular thickness	1.1	1.6	4.0	2.0	-0.2	-1.3	-0.7
Bone: trabecular tissue density	0.2	0.3	0.9	-0.3	-0.1	-0.3	1.0
Water consumed over 24 hours	0.4	0.8	2.9	-0.1	-1.7	-0.5	0.2
Number of responses in last shaping day	0.2	0.2	0.7	0.4	-0.0	0.1	0.8