Hub : Genes

Casp8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver alternative TSS XM_039084164.1 0.07 0.04 1.4e-05 0.04 0.04 0.03 0.04 2.1e-05 3.6e-05 2.0e-04 7.9e-05
2 Adipose gene expression Casp8 0.12 0.07 5.1e-04 0.02 0 0 0.02 2.7e-03 9.1e-02 2.9e-01 4.6e-03
3 Liver gene expression Casp8 0.12 0.06 1.6e-09 0.06 0.09 0.09 0.08 2.1e-07 4.2e-10 1.2e-09 1.5e-09
4 Eye mRNA stability Casp8 0.24 0.13 9.7e-03 0.16 0.16 0.11 0.13 2.1e-03 2.1e-03 1.0e-02 4.5e-03
5 Eye alternative polyA NM_022277.1 0.26 0.13 8.1e-03 0.12 0.17 0.04 0.11 7.3e-03 1.5e-03 9.6e-02 9.4e-03
6 Brain gene expression Casp8 0.04 0.03 1.1e-03 0.03 0.01 0.01 0.01 1.0e-03 2.2e-02 2.6e-02 4.0e-02
7 Brain isoform ratio XM_039084164.1 0.03 0.02 5.9e-03 0.02 0.03 0.02 0.02 3.0e-03 2.1e-03 2.5e-03 4.9e-03
8 Liver mRNA stability Casp8 0.03 0.02 1.8e-03 0 0.02 0.02 0.01 1.0e-01 1.5e-03 4.7e-03 2.2e-02
9 Brain mRNA stability Casp8 0.04 0.02 2.0e-03 0 0.01 0.01 0.01 1.1e-01 5.6e-02 6.9e-02 8.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density1.62.77.9-1.80.4-2.8-0.7-1.22.02.0-1.70.6
Area under the delay curve0.10.10.2-0.2-0.00.10.10.1-0.3-0.30.4-0.4
BMI with tail2.06.517.23.9-4.11.72.93.2-0.50.4-1.41.5
BMI without tail1.42.98.31.5-2.90.72.82.3-1.2-0.70.2-0.7
Body weight0.00.20.5-0.5-0.1-0.70.70.2-0.3-0.20.2-0.6
Weight adjusted by age0.80.92.3-0.60.1-1.5-0.5-0.71.11.3-1.20.6
Bone surface1.52.67.9-2.81.7-2.8-0.4-1.21.11.0-0.7-0.4
Bone volume1.52.58.0-2.41.3-2.8-0.5-1.21.51.4-1.10.0
Breakpoint value in progressive ratio session1.11.32.1-0.60.8-1.2-0.9-0.91.41.4-1.31.2
Number of licking bursts0.50.61.0-0.40.8-0.9-0.8-0.71.00.9-0.80.7
Context. condit. distance diff. score0.60.72.40.7-0.50.9-1.5-1.20.1-0.60.8-0.6
Locomotion velocity, session 11.21.33.41.1-1.01.80.00.3-1.1-1.41.3-0.9
Locomotion distance, session 10.30.42.21.0-1.50.3-0.1-0.10.20.1-0.20.0
Locomotion velocity, session 20.40.51.10.6-1.00.60.60.5-0.7-0.80.7-0.8
Locomotion distance, session 21.52.15.90.7-1.90.62.41.9-1.5-1.00.6-1.0
Locomotion velocity, session 30.60.71.30.6-1.20.80.0-0.0-0.6-1.01.0-1.1
Locomotion distance, session 30.30.30.8-0.50.2-0.1-0.5-0.6-0.2-0.50.7-0.9
Stereotopy head waving bouts, day 30.40.51.41.2-0.40.60.40.70.10.4-0.71.1
Stereotopy head waving duration, day 31.11.32.81.7-1.60.61.01.30.20.7-1.11.3
Locomotion velocity, session 70.70.72.31.5-1.31.30.40.7-0.5-0.40.20.2
Locomotion distance, session 70.70.91.60.4-0.51.10.70.6-1.3-1.31.2-1.0
Stereotopy head waving bouts, day 70.91.12.3-1.20.6-1.3-1.3-1.51.20.7-0.3-0.3
Stereotopy head waving duration, day 70.30.30.8-0.4-0.5-0.8-0.4-0.60.90.6-0.5-0.1
Locomotion velocity, session 80.30.40.70.2-0.80.4-0.8-0.80.0-0.50.6-0.8
Locomotion distance, session 80.40.51.10.4-0.90.7-0.5-0.5-0.4-0.80.9-1.0
Degree of sensitization distance0.20.20.60.8-0.60.50.50.7-0.20.0-0.20.4
Degree of sensitization stereotypy0.91.02.6-1.60.3-1.2-0.9-1.40.5-0.10.5-1.4
Conditioned locomotion0.91.12.4-1.30.7-0.10.70.3-1.1-1.21.3-1.5
Cocaine response after cond. corrected1.11.22.8-1.60.8-0.4-1.0-1.3-0.1-0.91.3-1.7
Cocaine response after cond. not corrected2.02.14.3-2.11.2-1.9-1.8-2.11.40.7-0.2-0.6
Cocaine response before conditioning4.04.910.1-0.50.7-2.6-1.1-1.02.83.2-3.12.6
Saline control response0.40.61.1-0.1-0.3-1.0-0.3-0.51.01.1-1.00.6
Bone: connectivity density1.21.96.4-1.1-0.3-2.50.6-0.11.51.8-1.80.7
Bone: cortical apparent density2.02.67.62.7-0.82.70.91.8-1.2-0.70.21.3
Bone: cortical area0.50.74.1-1.02.0-0.20.30.3-0.7-0.40.5-0.0
Bone: cortical porosity1.92.15.4-2.32.3-1.6-1.4-1.70.80.30.2-0.5
Bone: cortical porosity2.52.86.9-2.62.5-2.1-1.5-1.91.00.6-0.1-0.4
Bone: cortical thickness0.60.92.10.90.71.31.11.4-1.2-0.70.30.6
Bone: cortical thickness0.70.82.71.00.10.1-0.30.20.71.0-1.21.7
Bone: cortical tissue density2.12.77.72.8-1.02.81.01.9-1.3-0.70.21.2
Condit. Reinf. active minus inactive responses1.61.82.4-0.71.4-1.3-1.3-1.11.51.6-1.41.4
Condit. Reinf. active-inactive response ratio0.60.61.2-0.20.6-0.7-0.5-0.41.01.1-1.01.1
Condit. Reinf. active responses1.41.73.0-1.51.7-1.5-1.4-1.41.21.1-0.70.6
Condit. Reinf. inactive responses0.20.30.7-0.90.9-0.3-0.2-0.4-0.2-0.40.5-0.6
Incentive salience index mean2.42.93.9-1.32.0-1.9-1.7-1.51.91.9-1.61.5
Condit. Reinf. lever presses1.21.63.0-1.21.7-1.3-1.5-1.41.21.1-0.80.8
Condit. Reinf. active minus inactive responses2.53.15.2-2.22.0-2.2-2.1-2.31.81.2-0.70.2
Condit. Reinf. active-inactive response ratio3.33.47.2-1.31.8-1.7-2.7-2.52.21.6-1.11.0
Condit. Reinf. active responses1.92.64.7-2.22.1-1.9-1.8-2.01.41.0-0.50.1
Condit. Reinf. inactive responses0.10.10.6-0.70.6-0.40.20.0-0.2-0.10.2-0.3
Condit. Reinf. lever presses1.21.73.90.20.9-0.5-1.4-0.81.61.6-1.52.0
Condit. Reinf. lever reinforcers received2.02.84.5-2.12.1-2.0-2.0-2.11.61.1-0.60.2
Conditioned reinforcement - actives0.20.20.40.20.20.60.30.4-0.5-0.50.4-0.1
Conditioned reinforcement - inactives0.70.82.3-0.81.50.6-0.2-0.0-0.8-1.11.2-0.6
Conditioned locomotion0.30.41.00.7-0.70.70.91.0-0.4-0.20.00.2
Patch foraging indifference point 0 sec0.20.41.20.8-0.20.30.50.80.20.5-0.71.1
Patch foraging indifference point AUC0.50.61.7-0.81.3-0.7-0.6-0.50.60.8-0.60.7
Delay disc. indifference point, 0s delay1.21.34.01.6-2.00.61.11.2-0.00.5-0.90.8
Delay disc. indifference point, 16s delay0.70.71.4-0.80.4-1.0-1.1-1.21.10.7-0.50.1
Delay disc. indifference point, 2s delay0.50.62.51.1-1.60.50.80.8-0.20.1-0.30.2
Delay disc. indifference point, 24s delay0.30.20.5-0.30.3-0.70.30.20.30.7-0.70.6
Delay disc. indifference point, 4s delay0.40.41.00.9-1.01.00.30.5-0.6-0.50.4-0.2
Delay disc. indifference point, 8s delay0.70.71.7-1.30.8-0.50.2-0.2-0.6-0.80.9-1.2
Indifference point function ln k0.20.20.80.3-0.90.40.10.0-0.3-0.50.5-0.7
Indifference point function log k0.20.20.80.3-0.90.40.10.0-0.3-0.50.5-0.7
Patch foraging total patch changes 0 sec0.50.72.31.0-0.30.30.40.70.50.9-1.11.5
Patch foraging total patch changes 12 sec0.20.31.30.40.70.20.00.40.10.5-0.61.1
Patch foraging total patch changes 18 sec1.01.33.81.6-0.30.90.71.30.10.7-1.11.9
Patch foraging total patch changes 24 sec0.50.61.0-0.30.9-0.5-0.7-0.50.80.9-0.81.0
Patch foraging total patch changes 6 sec0.71.02.60.4-0.4-0.60.50.60.91.4-1.61.6
Patch foraging time to switch 0 sec0.20.31.10.9-1.00.20.50.50.10.3-0.40.4
Patch foraging water rate 0 sec0.20.30.7-0.80.8-0.1-0.2-0.3-0.3-0.40.5-0.6
Patch foraging water rate 12 sec0.30.41.00.0-1.0-0.8-0.2-0.40.80.7-0.70.1
Patch foraging water rate 18 sec0.81.11.6-0.60.7-1.1-1.2-1.11.31.3-1.00.9
Patch foraging water rate 24 sec0.10.20.7-0.6-0.5-0.80.2-0.20.30.2-0.2-0.4
Patch foraging water rate 6 sec0.00.10.30.1-0.6-0.00.40.2-0.0-0.10.0-0.2
Seeking ratio, delayed vs. immediate footshock0.40.51.7-1.1-0.3-1.3-0.1-0.60.80.5-0.3-0.5
Distance traveled before self-admin1.61.74.2-2.01.6-1.8-1.1-1.41.00.7-0.3-0.3
Distance traveled after self-admin0.20.30.9-0.70.4-0.50.90.6-0.3-0.10.0-0.3
Extensor digitorum longus weight1.66.217.22.6-2.51.94.24.1-2.2-0.9-0.10.5
Bone: elastic displacement1.11.32.50.6-0.7-0.6-1.1-0.81.61.5-1.51.3
Bone: elastic work0.30.40.8-0.30.3-0.8-0.4-0.40.80.9-0.90.7
Bone: endosteal estimation1.43.07.3-2.72.4-2.5-1.2-1.71.21.0-0.6-0.0
Bone: endosteal perimeter1.22.57.1-2.72.0-2.3-1.1-1.61.00.6-0.1-0.6
Epididymis fat weight1.43.26.2-1.30.60.21.81.0-2.3-2.32.3-2.5
Delta time in closed arm before/after self-admin0.30.30.6-0.50.8-0.5-0.7-0.60.60.4-0.30.3
Delta time in open arm before/after self-admin2.62.56.0-2.42.4-1.2-1.9-2.10.4-0.00.6-0.8
Diff in mean of infusions in LGA sessions2.12.34.4-1.00.4-2.1-1.1-1.32.02.0-1.71.0
Delay discount exponential model param0.00.00.10.3-0.10.1-0.00.10.20.2-0.30.4
Extinction: sum of active levers before priming0.70.71.7-0.50.2-1.3-0.2-0.41.01.2-1.20.7
Active lever presses in extinction session 60.50.41.1-0.40.50.4-0.6-0.6-0.3-0.81.0-0.9
Bone: final force0.50.83.6-1.41.9-1.20.60.2-0.10.2-0.20.2
Bone: final moment0.50.82.3-1.01.5-1.20.60.40.20.7-0.80.7
Food consumed during 24 hour testing period0.70.82.41.6-1.20.90.81.1-0.10.2-0.50.9
Glucose0.81.22.71.4-1.21.21.51.6-1.0-0.4-0.00.4
Heart weight1.11.53.4-0.3-0.4-1.8-0.1-0.31.51.8-1.81.1
Delay discount hyperbolic model param0.10.10.10.00.2-0.2-0.2-0.10.40.3-0.30.3
Intermittent access intake day 1-15 change2.22.25.10.9-1.0-1.1-0.3-0.21.82.1-2.31.9
Intermittent access intake escalation2.52.55.70.7-0.6-1.3-0.6-0.52.02.3-2.42.0
Intermittent access intake escalation 22.02.04.1-0.0-0.3-1.6-1.0-1.01.92.0-1.91.4
Intermitt. access day 1 inactive lever presses0.60.61.71.2-0.41.30.61.0-0.7-0.50.20.5
Intermitt. access day 15 inactive lever presses0.20.30.5-0.20.3-0.5-0.2-0.10.50.7-0.70.7
Intermitt. access escalation Index2.52.24.00.4-0.21.41.81.6-2.0-1.91.6-1.2
Intermittent access day 1 total infusions0.50.61.70.20.31.3-0.6-0.3-0.6-1.01.1-0.5
Intermittent access day 15 total infusions0.50.61.80.8-0.20.4-0.7-0.20.80.8-0.91.3
Intermittent access terminal intake (last 3 days)0.80.92.60.8-0.20.3-0.9-0.31.11.1-1.11.6
Intermittent access total infusions0.20.30.80.60.10.9-0.7-0.20.20.0-0.10.7
Intermittent access day 1 locomotion0.40.42.20.60.41.5-0.40.2-0.4-0.60.50.4
Intermittent access day 15 total locomotion0.30.31.10.30.30.2-0.5-0.10.50.6-0.61.0
Intermittent access total locomotion0.20.31.30.60.01.2-0.40.1-0.3-0.50.40.2
Intermittent access standard deviation0.91.02.31.1-0.40.4-1.5-0.91.10.9-0.81.3
Left kidney weight0.41.02.7-0.00.1-1.01.61.30.21.0-1.31.0
Right kidney weight0.20.51.7-0.40.0-1.30.80.40.40.9-1.00.5
Cocaine induced anxiety0.50.52.40.3-0.6-0.01.51.3-0.6-0.1-0.1-0.0
Post-drug Anxiety0.20.20.80.2-0.9-0.20.60.3-0.1-0.0-0.1-0.4
Baseline Anxiety0.91.03.4-0.80.8-0.2-1.8-1.70.5-0.20.6-0.7
Tail length2.47.321.6-4.74.0-2.2-1.6-2.5-0.3-1.22.1-2.8
Length with tail2.69.526.8-5.24.7-2.7-2.5-3.30.1-0.92.0-2.7
Length without tail1.02.36.9-2.02.6-1.3-1.9-1.90.80.50.00.0
Times rat made contact with spout0.70.81.61.3-1.21.30.70.8-0.7-0.70.5-0.2
Lifetime Intake0.20.31.10.8-0.21.1-0.40.1-0.1-0.20.10.5
Liver weight, left0.71.12.9-1.10.30.00.80.3-1.2-1.31.4-1.7
Liver weight, right2.03.47.3-2.31.6-2.7-1.7-2.11.91.6-1.10.3
Locomotor activity0.60.92.90.8-0.70.61.71.7-0.8-0.3-0.00.2
Locomotor testing distance1.11.83.81.6-1.50.31.91.9-0.10.6-1.21.3
Locomotor testing rearing0.10.10.20.2-0.30.20.40.3-0.3-0.40.3-0.3
Locomotion in novel chamber4.45.512.22.2-2.1-0.7-0.30.22.53.1-3.53.4
Locomotion in novel chamber post-restriction0.50.71.3-0.30.6-0.8-0.4-0.30.91.1-1.11.1
Fecal boli incidents, locomotor time 10.60.71.2-0.81.1-0.9-1.0-1.00.70.7-0.50.4
Change in fecal boli incidents, locomotor task0.20.20.50.5-0.50.40.60.7-0.2-0.0-0.20.3
Time >=10cm from walls, locomotor time 10.20.20.7-0.40.90.20.30.3-0.6-0.50.6-0.3
Bouts of movement, locomotor time 11.11.24.30.01.30.2-2.1-1.40.90.7-0.41.1
Total resting periods, locomotor time 10.80.93.30.71.01.0-1.8-1.00.50.3-0.11.1
Rest time, locomotor task time 11.82.07.41.9-0.22.70.21.0-1.5-1.51.20.1
Distance moved, locomotor task time 11.31.45.6-2.40.9-1.80.4-0.40.0-0.20.4-1.4
Vertical activity count, locomotor time 10.40.41.5-1.20.2-0.80.1-0.4-0.0-0.40.5-1.1
Time >=10cm from walls, locomotor time 21.31.34.60.4-1.20.32.11.7-1.2-0.80.5-0.8
Bouts of movement, locomotor time 20.20.20.50.2-0.6-0.4-0.1-0.10.70.7-0.70.4
Total resting periods, locomotor time 20.30.30.70.3-0.3-0.3-0.5-0.30.80.7-0.70.6
Rest time, locomotor task time 20.91.04.01.10.72.0-0.30.4-0.9-1.21.00.2
Distance moved, locomotor task time 20.40.51.5-1.0-0.1-1.21.20.6-0.20.2-0.2-0.5
Vertical activity count, locomotor time 21.82.05.31.4-2.30.32.32.1-0.50.2-0.70.4
Light reinforcement 12.54.59.33.1-2.92.02.72.9-1.3-0.4-0.30.7
Light reinforcement 20.20.21.00.1-0.4-0.11.00.8-0.5-0.20.1-0.3
Bone: marrow area1.43.07.1-2.72.5-2.5-1.3-1.71.31.1-0.60.1
Bone: maximum diameter1.12.08.1-2.22.9-0.9-1.1-1.2-0.1-0.40.8-0.7
Bone: maximum force0.71.23.5-1.41.4-1.90.70.20.61.0-1.00.6
Bone: maximum moment0.81.43.2-0.80.9-1.80.80.40.91.5-1.61.2
Mean time between licks in bursts2.94.17.40.8-0.92.12.32.1-2.7-2.52.1-1.7
Mean num. licks in bursts1.82.13.31.4-1.61.81.61.7-1.6-1.41.0-0.7
Cd content in liver0.10.10.3-0.50.2-0.4-0.2-0.40.20.10.0-0.3
Co content in liver1.01.24.80.20.1-0.1-2.2-1.71.30.8-0.50.5
Cu content in liver0.20.21.1-0.71.1-0.20.20.2-0.4-0.20.20.0
Fe content in liver1.72.14.1-0.60.3-1.8-0.8-0.81.92.0-1.91.4
K content in liver0.70.72.5-1.01.6-0.0-0.7-0.7-0.3-0.60.8-0.6
Mg content in liver0.10.10.2-0.40.4-0.5-0.1-0.20.20.3-0.30.1
Mn content in liver0.70.82.81.7-0.41.4-0.70.00.20.2-0.41.2
Na content in liver0.60.72.4-1.11.6-0.7-0.9-0.90.40.3-0.10.2
Rb content in liver0.70.93.0-1.30.2-0.3-0.3-0.7-0.4-0.91.2-1.7
Se content in liver0.40.51.30.00.1-0.60.60.60.40.9-1.11.1
Sr content in liver1.51.42.80.70.11.70.91.2-1.6-1.51.3-0.5
Zn content in liver0.80.81.90.4-0.20.91.41.3-1.3-0.90.6-0.3
Bone: minimum diameter0.51.04.8-1.42.2-1.20.40.2-0.00.4-0.40.5
Time in familiar zone, hab. session 11.31.23.10.0-1.0-1.0-1.0-1.01.81.4-1.30.6
Time in novel zone, hab. session 11.01.02.3-0.10.91.10.30.4-1.5-1.41.4-0.7
Total zone transitions, hab. session 10.40.61.7-0.90.4-0.8-1.2-1.30.60.10.2-0.6
Total locomotion distance, hab. session 11.52.13.6-1.31.3-1.6-1.9-1.81.61.3-0.90.6
Locomotion velocity, hab. session 11.01.42.0-1.21.3-1.4-1.3-1.31.21.1-0.80.6
Time in familiar zone, hab. session 20.91.02.30.60.2-0.4-0.8-0.51.31.3-1.31.5
Time in novel zone, hab. session 21.01.01.90.3-0.80.91.11.0-1.4-1.21.0-1.0
Total zone transitions, hab. session 20.30.41.50.7-1.20.40.60.5-0.3-0.40.2-0.4
Total locomotion distance, hab. session 20.30.31.40.5-1.2-0.10.90.7-0.10.1-0.3-0.1
Locomotion velocity, hab. session 20.20.31.20.5-1.10.00.90.7-0.2-0.0-0.2-0.1
Novel to familiar place preference ratio0.20.20.50.2-0.70.20.60.5-0.4-0.40.3-0.4
Novelty place preference0.10.10.40.2-0.70.10.60.5-0.3-0.20.1-0.2
Time in novel zone, NPP test0.10.10.60.3-0.8-0.00.60.4-0.10.0-0.1-0.1
Total zone transitions, NPP test0.10.20.5-0.10.0-0.3-0.7-0.70.40.2-0.0-0.1
Total locomotion distance, NPP test0.91.32.80.3-0.3-1.1-0.5-0.41.41.7-1.71.4
Locomotion velocity, NPP test0.71.02.40.5-0.2-0.8-0.3-0.21.21.5-1.51.5
Intraocular pressure1.62.37.02.6-1.71.41.21.7-0.20.5-1.01.7
Delta distance traveled before/after self-admin1.11.23.31.3-1.20.81.81.8-0.8-0.3-0.10.3
Delta ambulatory time before/after self-admin1.51.63.71.3-0.81.41.81.9-1.4-1.00.6-0.1
Parametrial fat weight0.30.51.00.0-0.10.70.70.6-1.0-1.00.9-0.8
Pavlov. Cond. lever latency1.41.83.21.4-1.31.51.81.8-1.5-1.10.7-0.4
Pavlov. Cond. magazine entry latency2.43.14.5-1.21.6-2.0-1.6-1.52.12.1-1.81.5
Pavlov. Cond. change in total contacts2.22.43.8-0.80.9-1.8-1.5-1.41.91.9-1.71.4
Pavlov. Cond. index score2.73.45.6-1.41.8-1.9-2.4-2.22.11.9-1.41.2
Pavlov. Cond. latency score3.03.86.2-1.61.8-2.1-2.5-2.42.31.9-1.41.1
Pavlov. Cond. lever contacts1.61.93.3-0.81.0-1.4-1.8-1.71.71.5-1.21.0
Pavlov. Cond. magazine entry number1.72.13.11.2-1.41.81.41.4-1.7-1.61.3-1.0
Pavlov. Cond. intertrial magazine entries0.20.30.8-0.4-0.0-0.0-0.1-0.3-0.4-0.70.8-0.9
Pavlov. Cond. lever-magazine prob. diff.2.63.25.2-1.11.6-1.7-2.3-2.02.11.9-1.51.4
Pavlov. Cond. response bias2.12.53.3-1.31.8-1.7-1.8-1.71.71.6-1.31.2
Pavlov. Cond. lever latency1.31.73.3-0.2-1.10.51.71.1-1.6-1.51.4-1.8
Pavlov. Cond. magazine entry latency0.40.41.40.60.70.5-1.2-0.60.40.2-0.10.8
Pavlov. Cond. change in total contacts1.52.06.6-1.12.6-0.5-2.3-1.81.00.5-0.10.6
Pavlov. Cond. index score1.01.33.7-0.01.70.0-1.9-1.31.00.7-0.51.2
Pavlov. Cond. latency score1.01.23.4-0.01.7-0.0-1.8-1.21.00.7-0.51.2
Pavlov. Cond. lever contacts1.41.93.4-0.11.4-0.6-1.9-1.31.61.5-1.31.8
Pavlov. Cond. magazine entry number0.40.51.6-0.0-1.2-0.21.30.8-0.4-0.20.0-0.6
Pavlov. Cond. intertrial magazine entries0.50.61.3-0.1-1.1-1.10.80.40.60.9-1.00.2
Pavlov. Cond. lever-magazine prob. diff.1.01.23.7-0.21.80.0-1.9-1.30.90.5-0.31.0
Pavlov. Cond. response bias0.91.22.9-0.01.4-0.3-1.7-1.21.21.0-0.81.3
Time in closed arm before self-admin0.91.02.2-1.51.2-1.0-1.3-1.50.40.10.3-0.7
Time in closed arm after self-admin1.31.43.4-1.41.0-1.2-1.7-1.90.90.40.1-0.5
Time in open arm before self-admin3.63.99.12.5-2.01.92.93.0-1.5-0.80.10.5
Time in open arm after self-admin0.50.61.9-0.81.40.3-0.6-0.5-0.6-0.70.9-0.5
Bone: periosteal estimation1.02.18.4-2.42.9-1.8-0.7-1.00.50.5-0.10.0
Bone: periosteal perimeter0.81.34.2-1.82.0-1.5-0.8-1.00.60.5-0.2-0.0
Bone: post-yield work0.91.22.90.5-0.7-0.81.00.90.81.4-1.71.5
Progressive ratio test 1 active lever presses0.30.41.01.00.00.90.20.6-0.10.1-0.31.0
Progressive ratio test 1 breakpoint0.40.51.80.90.00.5-0.10.40.40.6-0.71.3
Progressive ratio test 1 inactive lever presses2.93.27.22.7-1.72.51.92.4-1.4-0.90.30.8
Progressive ratio test 2 active lever presses0.10.20.60.40.30.80.00.4-0.1-0.1-0.00.6
Progressive ratio test 2 breakpoint0.30.31.00.80.00.80.10.50.10.2-0.31.0
Progressive ratio test 2 inactive lever presses0.50.62.20.8-0.01.50.30.7-0.8-0.80.60.2
Incentive Sensitization - Responses0.50.51.2-0.50.70.70.10.1-0.8-1.01.1-0.8
Incentive Sensitization - Breakpoint0.60.61.3-0.50.70.70.30.3-0.9-1.11.2-0.8
Sum of active levers in priming session hrs 5-60.40.41.5-1.21.0-0.7-0.0-0.3-0.0-0.20.4-0.6
Progressive ratio0.70.81.41.0-1.01.20.90.9-1.0-0.90.7-0.5
Food seeking constrained by brief footshock0.70.93.1-1.20.1-1.8-0.1-0.60.91.1-1.00.2
Seeking ratio, punishment vs. effort1.62.06.0-1.91.0-2.4-0.7-1.21.31.5-1.20.3
Retroperitoneal fat weight0.41.22.10.3-0.80.90.70.5-1.4-1.41.4-1.4
Reaction time number correct0.50.71.80.5-0.6-0.4-0.00.10.91.2-1.31.2
Reaction time mean minus median0.00.00.1-0.10.1-0.2-0.2-0.20.30.1-0.10.0
Reaction time mean minus median AUC0.40.51.00.20.2-0.4-0.9-0.71.00.9-0.80.9
Reaction time num false alarms1.92.55.71.6-1.51.52.42.3-1.8-1.10.6-0.3
Reaction time num false alarms AUC2.12.97.11.7-1.51.52.72.5-1.9-1.20.6-0.3
Reaction time trials correct on left0.50.71.80.5-0.6-0.4-0.00.10.91.2-1.31.2
Reaction time trials on left0.50.61.70.5-0.6-0.4-0.00.10.81.2-1.31.1
Reaction time mean1.42.04.3-1.41.60.4-1.0-1.1-0.8-1.72.1-1.9
Reaction time mean AUC1.21.63.7-1.11.40.5-0.7-0.8-0.8-1.61.9-1.7
Median of all reaction times2.33.27.0-1.72.10.6-1.1-1.3-1.1-2.22.6-2.3
Reaction time omissions0.40.51.3-0.50.40.4-0.2-0.3-0.6-1.01.1-1.1
Reaction time false alarm rate1.82.55.21.1-0.91.42.32.1-2.1-1.71.2-0.9
Reaction time premature initiation rate1.82.45.90.40.3-1.2-0.20.11.82.3-2.42.4
Reaction time premature initiations2.33.38.40.7-0.2-1.3-0.10.22.02.7-2.92.8
Std. dev. reaction times0.30.41.0-1.00.8-0.6-0.6-0.80.2-0.20.5-0.7
Reaction time trials completed0.50.61.70.5-0.6-0.4-0.00.10.81.2-1.31.1
Reaction time trials AUC0.30.51.30.4-0.5-0.4-0.10.00.71.0-1.11.0
Run reversals in cocaine runway, females0.30.30.70.3-0.10.80.10.2-0.8-0.70.7-0.4
Run reversals in cocaine runway, males0.40.41.40.00.90.1-1.2-0.80.50.2-0.10.5
Latency to leave start box in cocaine runway2.02.26.42.5-2.21.71.31.7-0.4-0.1-0.40.9
Latency to leave start box in cocaine runway, F0.70.82.31.5-1.11.40.60.9-0.6-0.50.20.3
Latency to leave start box in cocaine runway, M2.42.34.81.6-1.6-0.30.50.71.51.9-2.22.0
Std. dev. time between licks in bursts0.70.92.01.2-1.00.91.31.4-0.7-0.2-0.20.4
Total sessions with >9 infusions0.60.72.11.5-0.81.20.51.0-0.2-0.0-0.30.9
Short access day 1 total inactive lever presses0.10.10.10.1-0.20.20.40.4-0.3-0.30.2-0.1
Short access day 10 total inactive lever presses0.30.30.70.2-0.20.60.10.1-0.7-0.80.8-0.7
Short access day 1 total infusions0.30.41.11.1-0.70.6-0.20.20.30.4-0.50.9
Short access day 10 total infusions0.10.10.30.5-0.30.4-0.3-0.10.20.1-0.20.4
Short access total infusions0.40.41.51.2-0.71.2-0.20.3-0.2-0.30.20.4
Short access day 1 locomotion0.40.51.10.90.41.10.30.8-0.3-0.1-0.11.1
Short access day 10 total locomotion0.30.41.40.30.50.4-1.2-0.70.60.4-0.30.8
Short access total locomotion0.30.31.10.8-0.21.10.00.4-0.3-0.30.20.4
One hour access (0.3 mA shock)0.80.92.70.40.90.5-1.6-0.90.90.7-0.61.4
Compulsive drug intake0.30.30.8-0.10.90.1-0.8-0.40.50.4-0.40.8
One hour access (shock baseline)0.10.10.20.30.20.5-0.5-0.20.1-0.10.10.2
Social response proportion0.50.51.8-1.30.7-1.30.1-0.40.20.4-0.2-0.4
Social responses0.60.82.7-1.71.5-1.00.40.0-0.4-0.30.4-0.6
Social time0.10.20.6-0.80.7-0.7-0.1-0.30.10.2-0.0-0.1
Soleus weight0.31.04.3-0.1-0.9-0.82.11.5-0.10.5-0.80.2
Bone: stiffness1.01.65.8-2.42.0-1.8-0.0-0.70.20.10.2-0.8
Tibialis anterior weight0.10.20.60.4-0.10.40.80.8-0.5-0.30.10.1
Time to tail flick, vehicle, before self-admin0.20.20.50.4-0.10.50.70.7-0.6-0.30.20.0
Time to tail flick, vehicle, after self-admin0.20.30.70.3-0.30.40.80.7-0.6-0.50.3-0.2
Time to tail flick, test, before self-admin0.70.71.4-0.0-0.00.70.70.6-1.0-1.21.1-1.0
Time to tail flick, test, after self-admin0.90.93.01.5-1.70.4-0.00.30.70.7-0.90.9
Delta time to tail flick, vehicle, before/after SA0.20.20.90.5-0.90.10.40.4-0.00.1-0.2-0.0
Delta time to tail flick, test, before/after SA2.01.83.61.4-1.3-0.2-0.5-0.11.51.7-1.91.9
Tibia length1.54.313.6-3.73.4-2.6-1.2-1.90.60.20.4-1.0
Ambulatory time before self-admin0.70.72.5-1.60.6-1.5-0.1-0.60.60.3-0.1-0.7
Ambulatory time after self-admin0.60.63.1-0.1-0.1-0.31.81.4-0.5-0.0-0.30.1
Bone: tissue strength0.50.52.2-0.2-0.4-0.81.51.0-0.10.3-0.50.1
Total heroin consumption0.40.51.3-0.10.3-0.70.40.30.51.0-1.11.1
Bone: trabecular number1.32.17.4-1.80.1-2.7-0.3-1.01.71.6-1.30.0
Bone: trabecular spacing1.31.74.50.70.12.1-0.20.3-1.6-1.81.8-1.0
Bone: trabecular thickness1.31.53.7-0.6-0.2-1.90.0-0.31.61.8-1.81.0
Bone: trabecular tissue density0.40.52.10.11.51.1-0.7-0.2-0.5-0.60.60.3
Water consumed over 24 hours2.12.66.02.5-1.90.71.11.50.61.3-1.82.1
Number of responses in last shaping day0.50.51.80.30.4-0.00.40.70.40.8-1.01.3