Hub : Genes

Casp8

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression Casp8 0.13 0.07 1.4e-04 0.02 0.01 0.01 0.02 6.3e-03 1.2e-02 1.1e-02 2.6e-03
2 Liver gene expression Casp8 0.11 0.06 1.8e-09 0.06 0.09 0.07 0.08 1.8e-07 6.0e-10 1.2e-08 2.7e-09
3 IL gene expression Casp8 0.15 0.09 6.5e-03 0.1 0.08 0.08 0.08 2.6e-03 5.2e-03 5.3e-03 5.0e-03
4 Eye isoform ratio NM_022277.1 0.46 0.29 8.6e-03 0.02 0.05 0.11 0.07 1.6e-01 5.5e-02 9.4e-03 3.2e-02
5 Brain mRNA stability Casp8 0.03 0.02 6.2e-03 0.02 0.01 0.01 0.01 1.0e-02 3.2e-02 4.1e-02 7.5e-02
6 PL gene expression Casp8 0.06 0.03 5.6e-07 0.05 0.04 0.04 0.05 2.1e-06 2.9e-05 1.3e-05 6.0e-06
7 Brain gene expression Casp8 0.05 0.03 5.5e-05 0.05 0.05 0.04 0.04 2.0e-05 2.6e-05 6.7e-05 9.0e-05
8 NAcc gene expression Casp8 0.04 0.02 1.8e-06 0.04 0.04 0.03 0.04 1.9e-06 2.0e-06 5.5e-06 2.0e-06
9 BLA gene expression Casp8 0.07 0.05 8.1e-04 0.08 0.04 0.05 0.06 7.4e-05 2.7e-03 1.8e-03 3.5e-04
10 Liver mRNA stability Casp8 0.03 0.02 2.1e-03 0.02 0.03 0.03 0.02 4.9e-03 5.9e-04 2.5e-04 1.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.22.16.2-1.1-2.50.8-0.5-0.2-0.2-1.6-1.6-1.8-2.1
Area under the delay curve0.20.20.40.10.30.00.6-0.30.60.50.50.60.4
BMI with tail1.86.128.55.32.22.72.73.40.01.00.61.0-0.7
BMI without tail0.61.96.92.61.11.71.60.71.41.21.01.00.0
Body weight0.10.31.0-0.3-0.60.8-0.7-0.71.00.50.20.4-0.3
Weight adjusted by age0.71.12.4-0.8-1.6-0.1-0.90.5-1.0-1.2-1.1-1.3-1.2
Bone surface1.22.15.6-2.4-2.41.1-1.1-1.80.4-0.8-0.8-0.9-1.4
Bone volume1.12.05.9-2.0-2.41.0-0.9-1.20.2-1.1-1.1-1.2-1.7
Breakpoint value in progressive ratio session0.50.61.0-0.9-1.0-0.2-0.90.1-0.9-1.0-0.9-0.7-0.9
Number of licking bursts0.40.61.7-0.6-0.8-0.2-1.30.3-0.9-0.8-0.8-0.9-0.6
Context. condit. distance diff. score0.91.06.60.60.8-2.6-0.60.4-0.2-0.0-0.10.01.4
Locomotion velocity, session 11.31.53.21.11.8-1.21.60.10.71.01.01.01.6
Locomotion distance, session 10.30.31.81.30.3-0.50.51.0-0.0-0.3-0.2-0.3-0.0
Locomotion velocity, session 20.40.50.80.90.70.30.7-0.00.90.70.70.70.6
Locomotion distance, session 21.72.36.01.50.72.41.8-0.62.11.51.51.50.0
Locomotion velocity, session 30.40.51.01.00.8-0.50.20.00.90.60.60.61.0
Locomotion distance, session 30.20.20.5-0.30.0-0.7-0.1-0.60.60.20.30.20.6
Stereotopy head waving bouts, day 30.30.31.20.80.50.40.01.1-1.0-0.2-0.2-0.2-0.3
Stereotopy head waving duration, day 30.70.82.21.50.41.01.01.5-0.6-0.3-0.3-0.3-0.9
Locomotion velocity, session 70.50.61.91.41.2-0.30.70.9-0.10.40.40.40.6
Locomotion distance, session 70.70.91.60.41.10.10.7-0.71.11.21.31.21.1
Stereotopy head waving bouts, day 70.70.71.3-1.0-1.1-1.1-0.7-0.2-0.3-1.0-1.0-1.0-0.5
Stereotopy head waving duration, day 70.40.51.00.1-0.9-0.20.50.5-0.1-0.9-0.9-0.9-1.0
Locomotion velocity, session 80.30.32.30.50.3-1.50.20.10.5-0.0-0.10.10.7
Locomotion distance, session 80.30.51.40.80.6-1.20.2-0.00.80.40.40.51.0
Degree of sensitization distance0.10.10.40.70.50.30.50.4-0.00.20.20.3-0.1
Degree of sensitization stereotypy0.50.51.3-1.0-1.1-0.7-0.0-0.90.8-0.5-0.5-0.5-0.3
Conditioned locomotion0.91.13.7-0.90.10.50.7-1.91.51.01.00.90.6
Cocaine response after cond. corrected0.60.72.0-1.2-0.4-1.3-0.1-1.41.10.20.10.20.6
Cocaine response after cond. not corrected1.41.63.5-1.8-1.9-1.3-0.8-0.8-0.1-1.3-1.4-1.3-0.8
Cocaine response before conditioning4.35.28.6-0.7-2.60.5-1.51.7-2.6-2.8-2.8-2.8-2.9
Saline control response0.30.51.0-0.2-1.0-0.0-0.80.2-0.4-0.8-0.9-0.8-0.8
Bone: connectivity density1.32.05.8-0.3-2.22.2-0.2-0.00.2-1.1-1.2-1.3-2.4
Bone: cortical apparent density1.31.86.31.62.5-0.20.71.1-0.91.21.21.11.5
Bone: cortical area0.81.23.2-1.60.30.8-1.1-1.80.31.11.11.10.8
Bone: cortical porosity1.61.76.1-2.5-1.4-0.9-2.2-1.2-0.5-0.8-0.8-0.7-0.2
Bone: cortical porosity2.42.68.2-2.9-2.1-0.5-2.5-1.3-0.6-1.2-1.2-1.2-0.8
Bone: cortical thickness0.81.32.60.11.51.1-0.2-0.60.01.61.61.61.2
Bone: cortical thickness0.30.41.30.70.40.1-0.51.1-1.1-0.3-0.3-0.3-0.2
Bone: cortical tissue density1.41.96.51.82.5-0.10.81.1-0.81.31.21.21.5
Condit. Reinf. active minus inactive responses1.61.83.0-1.2-1.4-0.6-1.70.5-1.7-1.5-1.6-1.5-1.1
Condit. Reinf. active-inactive response ratio0.60.71.2-0.5-0.8-0.1-0.90.5-1.1-0.9-1.0-0.9-1.0
Condit. Reinf. active responses1.21.53.1-1.8-1.5-0.6-1.6-0.3-1.1-1.2-1.2-1.2-0.8
Condit. Reinf. inactive responses0.20.20.9-0.9-0.2-0.0-0.4-1.00.30.20.20.20.4
Incentive salience index mean2.43.05.2-1.8-1.9-0.7-2.30.4-2.0-1.9-1.9-1.9-1.4
Condit. Reinf. lever presses1.11.53.7-1.7-1.3-1.0-1.9-0.1-1.3-1.2-1.2-1.2-0.4
Condit. Reinf. active minus inactive responses2.12.74.7-2.2-2.1-1.3-1.8-0.5-1.2-1.8-1.8-1.8-1.1
Condit. Reinf. active-inactive response ratio3.23.85.6-1.7-1.7-2.1-2.40.7-2.3-2.2-2.2-2.3-1.0
Condit. Reinf. active responses1.42.05.0-2.2-1.8-1.3-1.4-0.8-0.9-1.4-1.4-1.4-0.8
Condit. Reinf. inactive responses0.20.30.8-0.8-0.30.30.6-0.90.60.30.20.3-0.1
Condit. Reinf. lever presses1.72.46.3-0.4-0.8-1.1-1.51.6-2.5-1.8-1.9-1.8-1.1
Condit. Reinf. lever reinforcers received1.72.34.9-2.2-1.9-1.3-1.7-0.6-1.1-1.6-1.6-1.6-1.0
Conditioned reinforcement - actives0.00.00.20.20.30.4-0.00.2-0.30.30.00.0-0.2
Conditioned reinforcement - inactives0.60.92.5-1.60.5-0.6-1.0-1.40.20.90.50.61.0
Conditioned locomotion0.60.82.00.80.91.41.2-0.40.80.90.80.80.2
Patch foraging indifference point 0 sec0.10.20.70.50.20.70.20.8-0.7-0.3-0.3-0.2-0.5
Patch foraging indifference point AUC0.40.51.4-1.2-0.8-0.3-0.8-0.1-0.9-0.7-0.6-0.8-0.5
Delay disc. indifference point, 0s delay1.01.13.81.90.71.01.81.20.30.40.20.6-0.3
Delay disc. indifference point, 16s delay0.30.41.1-0.6-1.0-0.8-0.60.0-0.1-0.5-0.8-0.4-0.4
Delay disc. indifference point, 2s delay0.50.62.11.40.60.61.40.70.20.00.30.3-0.2
Delay disc. indifference point, 24s delay0.10.20.9-0.3-0.60.9-0.2-0.00.20.20.00.3-0.5
Delay disc. indifference point, 4s delay0.50.51.70.90.9-0.31.30.30.30.40.40.40.8
Delay disc. indifference point, 8s delay0.70.82.9-1.1-0.30.30.1-1.71.30.80.80.90.3
Indifference point function ln k0.10.20.50.60.4-0.10.70.10.70.30.40.40.3
Indifference point function log k0.10.20.50.60.4-0.10.70.10.70.30.40.40.3
Patch foraging total patch changes 0 sec0.40.72.00.70.00.70.11.4-1.2-0.7-0.7-0.6-0.9
Patch foraging total patch changes 12 sec0.20.21.4-0.10.10.2-0.50.5-1.2-0.4-0.2-0.4-0.2
Patch foraging total patch changes 18 sec0.50.82.51.00.60.9-0.01.6-1.6-0.5-0.3-0.4-0.5
Patch foraging total patch changes 24 sec0.50.92.0-0.7-0.8-0.3-1.10.6-1.4-1.1-1.2-1.1-0.8
Patch foraging total patch changes 6 sec0.81.22.70.5-0.81.30.31.3-1.0-1.1-1.1-1.2-1.6
Patch foraging time to switch 0 sec0.10.21.01.00.20.40.60.60.10.1-0.10.1-0.2
Patch foraging water rate 0 sec0.10.10.7-0.9-0.2-0.3-0.1-0.70.2-0.00.10.10.2
Patch foraging water rate 12 sec0.20.51.00.5-0.9-0.00.20.6-0.1-1.0-0.9-0.9-1.0
Patch foraging water rate 18 sec0.71.12.1-0.6-1.1-0.8-0.80.5-1.2-1.4-1.3-1.4-0.9
Patch foraging water rate 24 sec0.10.20.5-0.0-0.70.4-0.0-0.00.6-0.2-0.3-0.2-0.7
Patch foraging water rate 6 sec0.10.10.60.40.10.30.70.00.3-0.00.10.1-0.1
Seeking ratio, delayed vs. immediate footshock0.50.62.0-0.3-1.40.50.4-0.41.1-0.0-0.8-0.0-1.1
Distance traveled before self-admin0.70.93.1-1.8-1.50.1-0.9-1.30.3-0.4-0.5-0.3-0.5
Distance traveled after self-admin0.70.83.2-0.5-0.31.80.5-1.01.00.80.51.0-0.6
Extensor digitorum longus weight1.35.117.82.61.84.22.50.31.62.22.22.2-0.2
Bone: elastic displacement1.11.33.00.7-0.6-0.7-0.61.7-1.3-1.4-1.5-1.4-1.0
Bone: elastic work0.30.30.6-0.3-0.70.3-0.80.4-0.5-0.6-0.7-0.6-0.8
Bone: endosteal estimation1.32.88.0-2.8-2.4-0.1-2.1-1.2-0.8-1.4-1.4-1.4-1.2
Bone: endosteal perimeter0.91.85.7-2.4-2.10.0-1.6-1.40.0-0.9-1.0-1.0-0.9
Epididymis fat weight0.82.95.8-0.30.52.20.4-2.22.41.92.11.91.0
Delta time in closed arm before/after self-admin0.20.20.4-0.5-0.5-0.6-0.6-0.0-0.2-0.3-0.6-0.2-0.4
Delta time in open arm before/after self-admin2.32.28.3-2.9-1.5-1.8-1.8-1.3-0.6-1.0-0.8-1.2-0.2
Diff in mean of infusions in LGA sessions2.63.15.4-0.4-2.2-0.8-1.41.6-1.6-2.1-2.3-2.1-2.1
Delay discount exponential model param0.10.10.20.0-0.1-0.0-0.50.3-0.4-0.3-0.4-0.4-0.2
Extinction: sum of active levers before priming0.30.41.0-0.4-1.00.2-1.00.1-0.4-0.5-0.8-0.6-0.4
Active lever presses in extinction session 60.50.51.0-0.70.2-1.0-0.5-0.80.40.50.20.81.0
Bone: final force0.81.33.8-1.9-1.01.5-1.6-1.70.20.30.30.4-0.4
Bone: final moment0.61.02.5-1.5-1.01.6-1.5-1.1-0.10.0-0.00.1-0.7
Food consumed during 24 hour testing period0.30.51.91.40.80.40.71.1-0.40.20.20.2-0.0
Glucose0.50.82.51.60.61.41.30.90.20.40.40.4-0.3
Heart weight1.01.54.9-1.1-2.20.5-0.4-0.1-0.2-1.1-1.4-1.2-1.9
Delay discount hyperbolic model param0.20.20.4-0.0-0.3-0.0-0.70.4-0.5-0.4-0.6-0.6-0.3
Intermittent access intake day 1-15 change0.61.23.21.1-0.50.4-0.11.8-1.4-1.1-1.1-1.0-1.3
Intermittent access intake escalation0.81.53.91.3-0.50.6-0.12.0-1.6-1.2-1.2-1.2-1.5
Intermittent access intake escalation 21.11.31.90.1-1.2-0.5-0.81.3-1.2-1.4-1.4-1.4-1.2
Intermitt. access day 1 inactive lever presses0.41.35.42.31.51.10.91.6-1.00.00.20.10.0
Intermitt. access day 15 inactive lever presses0.30.71.50.6-0.50.8-0.21.1-1.2-0.9-0.6-0.8-1.1
Intermitt. access escalation Index1.82.54.20.71.81.51.3-1.21.62.11.92.01.3
Intermittent access day 1 total infusions0.10.21.1-0.10.6-1.1-0.30.2-0.40.2-0.10.10.5
Intermittent access day 15 total infusions0.50.72.11.20.60.40.21.5-1.4-0.5-0.6-0.6-0.6
Intermittent access terminal intake (last 3 days)0.91.13.21.20.30.00.01.8-1.7-1.0-1.0-1.1-0.9
Intermittent access total infusions0.30.41.20.80.5-0.00.11.1-1.1-0.4-0.5-0.4-0.3
Intermittent access day 1 locomotion0.10.20.60.20.8-0.4-0.20.5-0.60.2-0.20.10.2
Intermittent access day 15 total locomotion0.20.41.00.1-0.20.6-0.30.7-1.0-0.5-0.6-0.6-0.8
Intermittent access total locomotion0.10.20.50.70.60.20.40.7-0.5-0.1-0.10.0-0.1
Intermittent access standard deviation0.71.53.71.00.1-1.7-0.51.9-1.6-1.2-1.2-1.3-0.2
Left kidney weight0.41.810.11.0-0.93.21.00.60.50.1-0.3-0.1-2.1
Right kidney weight0.62.613.21.1-0.83.61.7-0.31.80.80.50.7-1.8
Cocaine induced anxiety0.91.23.90.10.42.01.0-1.31.31.21.31.00.2
Post-drug Anxiety0.60.61.50.50.20.91.0-1.01.20.70.90.50.4
Baseline Anxiety0.70.85.50.2-0.3-2.3-0.30.4-0.2-0.8-0.7-0.80.4
Tail length1.86.926.8-5.2-2.1-0.8-2.5-4.92.20.70.80.41.1
Length with tail1.77.530.3-5.5-2.9-1.8-3.8-4.11.0-0.6-0.4-0.70.3
Length without tail0.93.08.9-3.0-2.5-0.9-2.5-1.2-0.5-1.3-1.5-1.1-1.1
Times rat made contact with spout0.60.71.81.41.3-0.10.80.50.40.80.80.80.7
Lifetime Intake0.40.41.61.20.70.00.31.3-0.8-0.2-0.4-0.2-0.3
Liver weight, left0.50.93.3-1.2-0.1-0.4-0.2-1.81.30.60.70.70.9
Liver weight, right1.73.06.9-0.9-2.60.6-1.60.5-1.0-2.0-2.1-2.0-2.3
Locomotor activity0.50.83.50.80.61.91.2-0.10.50.70.70.7-0.2
Locomotor testing distance0.61.15.31.40.12.30.81.1-0.4-0.3-0.1-0.3-1.1
Locomotor testing rearing0.00.10.20.20.30.50.4-0.30.30.20.30.20.2
Locomotion in novel chamber4.45.613.92.0-1.40.3-0.33.7-2.6-2.4-2.9-2.5-2.9
Locomotion in novel chamber post-restriction0.81.22.4-0.6-1.2-0.0-1.10.7-1.3-1.5-1.2-1.3-1.2
Fecal boli incidents, locomotor time 10.60.93.3-0.8-1.0-0.6-1.80.3-0.9-0.8-1.0-0.7-0.5
Change in fecal boli incidents, locomotor task0.40.30.90.70.60.90.90.30.30.50.30.70.1
Time >=10cm from walls, locomotor time 10.30.30.8-0.70.30.2-0.4-0.90.20.80.60.70.5
Bouts of movement, locomotor time 11.61.86.4-0.80.1-2.5-1.80.7-2.0-1.0-0.9-1.00.6
Total resting periods, locomotor time 11.51.66.4-0.20.9-2.5-1.40.9-1.9-0.6-0.3-0.71.2
Rest time, locomotor task time 12.02.57.60.72.8-0.9-0.2-0.30.11.91.91.82.5
Distance moved, locomotor task time 11.01.53.8-1.9-1.91.20.0-1.81.1-0.3-0.4-0.2-0.9
Vertical activity count, locomotor time 10.20.41.4-0.9-0.90.20.4-1.20.8-0.1-0.40.1-0.1
Time >=10cm from walls, locomotor time 20.91.34.10.60.32.01.2-0.71.51.21.21.30.2
Bouts of movement, locomotor time 20.20.30.90.4-0.40.20.60.6-0.1-0.4-0.6-0.6-0.9
Total resting periods, locomotor time 20.20.30.90.3-0.3-0.20.20.7-0.5-0.5-0.8-0.7-1.0
Rest time, locomotor task time 20.91.14.00.22.0-1.3-0.70.1-0.61.10.80.81.6
Distance moved, locomotor task time 20.70.94.3-0.5-1.22.10.6-0.90.9-0.10.10.0-0.8
Vertical activity count, locomotor time 21.21.65.61.90.32.42.10.71.00.60.20.6-0.1
Light reinforcement 11.63.99.83.12.02.42.61.21.21.81.61.90.2
Light reinforcement 20.30.51.70.30.01.30.6-0.41.00.70.60.8-0.2
Bone: marrow area1.22.78.0-2.8-2.3-0.1-2.1-1.2-0.8-1.4-1.3-1.4-1.2
Bone: maximum diameter0.91.77.4-2.7-0.5-0.7-1.7-2.10.10.40.30.30.8
Bone: maximum force0.81.54.1-1.6-1.62.0-1.4-1.20.0-0.3-0.3-0.3-1.3
Bone: maximum moment0.81.44.6-1.0-1.62.2-1.2-0.4-0.3-0.6-0.6-0.5-1.6
Mean time between licks in bursts1.63.96.51.12.11.42.0-1.02.12.52.62.51.6
Mean num. licks in bursts1.21.93.71.61.70.61.90.01.21.51.51.51.0
Cd content in liver0.20.20.70.30.4-0.80.7-0.20.30.10.20.20.3
Co content in liver1.51.811.7-0.20.4-3.4-0.60.8-1.3-1.0-0.9-0.80.8
Cu content in liver0.20.31.0-0.7-0.41.00.1-0.60.20.20.30.2-0.7
Fe content in liver2.12.54.7-0.8-1.9-1.0-1.41.0-1.5-2.1-2.2-2.1-1.2
K content in liver0.90.92.4-1.50.1-0.5-1.1-1.50.50.60.70.61.2
Mg content in liver0.20.30.9-0.9-0.5-0.3-0.9-0.4-0.3-0.3-0.3-0.30.3
Mn content in liver1.01.23.11.11.8-1.1-0.11.5-1.30.30.30.31.4
Na content in liver0.60.73.1-1.8-0.9-0.4-0.6-1.40.1-0.3-0.2-0.1-0.4
Rb content in liver0.40.41.5-0.2-0.0-0.21.1-0.81.20.40.40.50.1
Se content in liver0.10.10.3-0.6-0.40.4-0.3-0.2-0.2-0.0-0.1-0.1-0.3
Sr content in liver0.90.81.80.01.20.3-0.1-0.70.51.11.21.21.3
Zn content in liver0.40.50.9-0.20.51.00.2-0.70.50.80.90.80.6
Bone: minimum diameter0.71.33.6-1.9-1.01.7-1.8-1.3-0.40.10.00.1-0.5
Time in familiar zone, hab. session 11.71.63.10.5-1.2-0.80.11.5-0.9-1.8-1.7-1.7-1.4
Time in novel zone, hab. session 11.31.32.4-0.51.20.0-0.2-1.20.71.51.51.51.5
Total zone transitions, hab. session 10.20.31.0-0.7-0.8-1.0-0.4-0.40.1-0.6-0.6-0.6-0.1
Total locomotion distance, hab. session 11.31.82.7-1.4-1.6-1.3-1.30.2-1.2-1.6-1.6-1.6-1.0
Locomotion velocity, hab. session 10.81.21.9-1.3-1.4-0.6-1.2-0.0-0.9-1.2-1.2-1.2-1.0
Time in familiar zone, hab. session 21.31.43.10.3-0.5-0.4-1.71.5-1.8-1.2-1.2-1.2-0.6
Time in novel zone, hab. session 21.31.43.80.51.00.72.0-0.81.51.31.21.30.6
Total zone transitions, hab. session 20.20.21.01.00.30.30.50.20.70.40.40.40.1
Total locomotion distance, hab. session 20.20.31.00.9-0.11.00.60.30.60.20.10.2-0.5
Locomotion velocity, hab. session 20.20.31.00.90.11.00.60.20.60.30.30.3-0.3
Novel to familiar place preference ratio0.20.20.50.50.20.50.6-0.20.70.40.30.4-0.0
Novelty place preference0.10.10.30.50.10.50.5-0.00.50.20.20.3-0.1
Time in novel zone, NPP test0.10.10.30.6-0.10.60.50.20.40.00.00.1-0.4
Total zone transitions, NPP test0.10.10.6-0.1-0.3-0.8-0.40.1-0.2-0.4-0.4-0.40.1
Total locomotion distance, NPP test1.01.42.20.3-1.20.2-0.71.3-1.3-1.4-1.4-1.4-1.5
Locomotion velocity, NPP test0.71.01.60.4-0.80.2-0.71.3-1.3-1.1-1.2-1.1-1.2
Intraocular pressure1.01.45.72.41.41.30.81.8-0.90.00.50.1-0.2
Delta distance traveled before/after self-admin0.90.91.81.11.01.31.30.10.61.10.91.1-0.3
Delta ambulatory time before/after self-admin1.21.53.10.91.51.21.2-0.41.01.61.41.80.5
Parametrial fat weight1.22.95.61.02.10.71.5-0.71.72.42.02.31.6
Pavlov. Cond. lever latency1.31.62.31.41.51.41.4-0.11.11.51.51.50.6
Pavlov. Cond. magazine entry latency2.22.84.2-1.5-2.0-0.5-1.90.6-1.8-2.0-2.0-2.0-1.6
Pavlov. Cond. change in total contacts2.22.33.7-0.9-1.9-0.5-1.50.7-1.6-1.9-1.9-1.9-1.4
Pavlov. Cond. index score2.53.24.6-1.7-2.0-1.6-2.10.5-1.9-2.1-2.1-2.1-1.0
Pavlov. Cond. latency score2.83.55.0-1.8-2.1-1.8-2.00.4-1.8-2.2-2.2-2.2-1.1
Pavlov. Cond. lever contacts1.62.03.0-1.1-1.5-1.4-1.50.6-1.5-1.7-1.7-1.7-0.8
Pavlov. Cond. magazine entry number1.72.23.81.41.90.51.6-0.31.41.81.81.71.3
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.20.1-0.3-0.5-0.60.60.40.30.30.5
Pavlov. Cond. lever-magazine prob. diff.2.53.14.6-1.5-1.8-1.5-2.20.6-2.0-2.1-2.1-2.1-1.0
Pavlov. Cond. response bias2.02.55.1-1.7-1.8-1.1-2.30.2-1.7-1.7-1.7-1.7-0.9
Pavlov. Cond. lever latency1.31.85.20.40.51.21.6-1.32.31.41.51.40.6
Pavlov. Cond. magazine entry latency0.50.72.0-0.10.3-1.3-1.20.8-1.4-0.5-0.5-0.50.5
Pavlov. Cond. change in total contacts1.32.16.5-1.9-0.5-2.1-2.5-0.2-1.8-0.9-1.0-0.90.5
Pavlov. Cond. index score1.21.64.4-0.9-0.1-1.8-2.10.7-2.1-1.0-1.0-0.90.3
Pavlov. Cond. latency score1.11.54.3-0.9-0.2-1.6-2.00.7-2.1-0.9-1.0-0.90.2
Pavlov. Cond. lever contacts2.02.76.9-0.8-0.9-1.5-2.11.3-2.6-1.8-1.8-1.7-0.7
Pavlov. Cond. magazine entry number0.50.71.90.6-0.31.31.4-0.31.40.30.40.3-0.6
Pavlov. Cond. intertrial magazine entries0.60.82.60.5-1.21.30.80.40.4-0.7-0.7-0.7-1.6
Pavlov. Cond. lever-magazine prob. diff.1.11.54.4-1.0-0.1-1.8-2.10.5-2.0-0.8-0.9-0.80.4
Pavlov. Cond. response bias1.41.94.7-0.7-0.6-1.5-1.91.1-2.2-1.4-1.5-1.4-0.4
Time in closed arm before self-admin0.50.61.7-1.3-0.5-1.1-1.2-0.7-0.2-0.3-0.1-0.50.6
Time in closed arm after self-admin0.60.62.1-1.1-0.9-1.5-1.0-0.3-0.2-0.4-0.6-0.70.0
Time in open arm before self-admin2.42.66.12.51.82.41.70.50.71.61.31.70.4
Time in open arm after self-admin0.50.51.8-1.3-0.6-0.7-1.2-0.5-0.6-0.4-0.5-0.5-0.1
Bone: periosteal estimation1.02.09.0-3.0-1.50.4-2.1-1.9-0.3-0.3-0.3-0.3-0.3
Bone: periosteal perimeter0.61.14.4-2.1-1.2-0.0-1.6-1.3-0.2-0.4-0.5-0.4-0.3
Bone: post-yield work0.71.03.00.7-0.81.70.31.1-0.6-0.7-0.8-0.8-1.7
Progressive ratio test 1 active lever presses0.60.72.40.80.30.3-0.31.5-1.4-0.6-0.7-0.6-0.7
Progressive ratio test 1 breakpoint0.60.72.20.70.10.2-0.31.5-1.4-0.7-0.8-0.6-0.8
Progressive ratio test 1 inactive lever presses1.62.38.12.82.11.71.81.4-0.20.90.80.70.2
Progressive ratio test 2 active lever presses0.20.31.00.10.20.4-0.30.8-1.0-0.2-0.4-0.4-0.6
Progressive ratio test 2 breakpoint0.30.31.10.20.20.4-0.30.8-1.1-0.2-0.5-0.4-0.6
Progressive ratio test 2 inactive lever presses0.10.20.90.50.70.1-0.10.7-0.90.0-0.1-0.10.0
Incentive Sensitization - Responses0.20.31.4-1.20.2-0.3-0.5-0.90.20.60.40.30.4
Incentive Sensitization - Breakpoint0.30.41.2-1.10.3-0.1-0.4-0.90.30.70.50.50.5
Sum of active levers in priming session hrs 5-60.70.71.7-1.3-0.40.2-0.4-1.31.00.90.31.00.1
Progressive ratio0.50.82.20.71.20.20.6-0.21.01.30.91.50.7
Food seeking constrained by brief footshock0.91.12.8-0.6-1.50.4-0.50.6-0.8-1.2-1.0-1.3-1.7
Seeking ratio, punishment vs. effort1.52.15.5-1.5-2.30.3-0.9-0.0-0.9-1.9-1.3-1.9-1.8
Retroperitoneal fat weight0.94.06.61.52.60.51.9-0.92.12.32.52.32.4
Reaction time number correct0.30.61.40.6-0.50.20.41.2-0.7-0.8-0.9-0.8-1.0
Reaction time mean minus median0.00.00.1-0.1-0.3-0.1-0.1-0.10.10.1-0.3-0.0-0.2
Reaction time mean minus median AUC0.20.61.1-0.1-0.5-0.8-0.90.9-1.0-0.8-1.0-0.9-0.5
Reaction time num false alarms1.62.34.51.81.52.11.10.01.31.81.91.70.6
Reaction time num false alarms AUC1.82.86.21.81.62.51.2-0.11.52.02.01.90.6
Reaction time trials correct on left0.30.61.40.6-0.50.20.41.2-0.7-0.8-0.9-0.8-1.0
Reaction time trials on left0.30.61.30.6-0.50.20.41.1-0.7-0.8-0.9-0.8-1.0
Reaction time mean1.11.83.8-1.70.4-1.6-0.9-2.01.31.30.71.11.6
Reaction time mean AUC0.91.52.9-1.40.5-1.3-0.8-1.71.11.30.71.11.5
Median of all reaction times2.02.86.0-2.10.6-2.0-1.1-2.41.51.61.11.42.1
Reaction time omissions0.10.10.5-0.10.1-0.10.2-0.40.70.40.20.40.1
Reaction time false alarm rate1.82.54.81.21.52.00.7-0.71.62.12.22.01.0
Reaction time premature initiation rate1.62.24.00.1-1.31.0-1.01.6-2.0-1.7-1.7-1.6-2.0
Reaction time premature initiations1.62.85.40.5-1.31.1-0.52.0-2.1-1.9-2.0-1.8-2.3
Std. dev. reaction times0.20.31.1-1.0-0.6-0.5-0.7-0.80.40.2-0.20.00.0
Reaction time trials completed0.30.61.30.6-0.50.20.41.1-0.7-0.8-0.9-0.8-1.0
Reaction time trials AUC0.20.40.90.5-0.40.10.41.0-0.6-0.7-0.8-0.7-0.8
Run reversals in cocaine runway, females0.20.20.6-0.10.7-0.50.00.0-0.30.10.50.00.7
Run reversals in cocaine runway, males0.90.92.8-0.4-0.0-1.3-1.70.5-1.3-0.8-0.6-0.90.4
Latency to leave start box in cocaine runway1.51.76.12.51.50.92.11.50.10.70.40.6-0.2
Latency to leave start box in cocaine runway, F0.91.12.51.51.60.31.50.50.41.00.90.90.7
Latency to leave start box in cocaine runway, M2.32.15.82.3-0.11.31.32.4-0.8-0.6-1.1-0.7-1.9
Std. dev. time between licks in bursts0.50.71.51.21.01.20.80.50.30.80.90.80.3
Total sessions with >9 infusions0.70.82.91.70.90.60.51.7-0.9-0.2-0.2-0.2-0.4
Short access day 1 total inactive lever presses0.40.50.90.50.50.80.7-0.60.90.90.80.70.3
Short access day 10 total inactive lever presses0.30.61.20.60.80.80.9-0.60.80.81.10.60.7
Short access day 1 total infusions0.30.31.41.20.6-0.10.31.1-0.5-0.0-0.3-0.1-0.2
Short access day 10 total infusions0.30.41.81.30.80.10.41.2-0.6-0.1-0.2-0.2-0.1
Short access total infusions0.40.52.21.51.0-0.10.61.2-0.40.2-0.00.20.1
Short access day 1 locomotion0.60.72.30.80.41.5-0.01.0-1.4-0.4-0.3-0.5-0.8
Short access day 10 total locomotion0.30.61.91.00.5-0.3-0.01.4-1.1-0.5-0.6-0.5-0.2
Short access total locomotion0.70.82.71.61.21.21.00.9-0.40.30.30.3-0.0
One hour access (0.3 mA shock)0.70.82.0-0.00.0-1.0-0.91.2-1.4-0.8-1.1-0.7-0.4
Compulsive drug intake0.20.20.60.30.3-0.6-0.30.7-0.7-0.3-0.3-0.30.2
One hour access (shock baseline)0.10.20.40.2-0.0-0.2-0.20.6-0.6-0.4-0.6-0.3-0.5
Social response proportion0.50.62.3-1.1-1.00.60.2-1.50.60.0-0.10.1-0.5
Social responses0.71.03.5-1.7-0.81.1-0.4-1.90.70.40.40.5-0.2
Social time0.10.20.8-0.9-0.50.2-0.2-0.8-0.1-0.2-0.1-0.2-0.1
Soleus weight0.51.59.80.6-0.83.10.8-0.00.90.20.10.1-1.6
Bone: stiffness1.01.76.2-2.5-1.60.9-1.2-2.30.80.10.10.0-0.4
Tibialis anterior weight0.10.20.80.10.30.90.3-0.40.40.60.50.60.1
Time to tail flick, vehicle, before self-admin0.20.20.5-0.10.50.2-0.5-0.10.10.60.40.70.7
Time to tail flick, vehicle, after self-admin0.20.30.90.30.31.00.1-0.20.50.50.70.30.9
Time to tail flick, test, before self-admin0.70.71.6-0.10.80.10.8-1.11.01.31.01.00.2
Time to tail flick, test, after self-admin1.31.33.71.2-0.4-1.0-0.11.9-1.1-1.2-1.4-1.3-0.6
Delta time to tail flick, vehicle, before/after SA0.30.31.01.00.00.40.80.7-0.2-0.5-0.1-0.6-0.1
Delta time to tail flick, test, before/after SA3.03.17.91.1-1.0-0.6-0.72.8-2.2-2.2-2.2-2.0-1.3
Tibia length1.33.514.2-3.8-2.4-0.0-2.6-2.80.3-0.6-0.6-0.5-0.5
Ambulatory time before self-admin0.50.72.1-1.1-1.30.9-0.2-1.41.0-0.0-0.1-0.0-0.4
Ambulatory time after self-admin1.31.56.6-0.3-0.02.60.8-1.31.31.11.01.4-0.3
Bone: tissue strength0.80.84.30.0-1.12.1-0.1-0.10.3-0.3-0.2-0.3-1.4
Total heroin consumption0.20.21.1-0.4-0.61.0-0.5-0.1-0.00.0-0.30.3-0.7
Bone: trabecular number1.21.96.3-1.1-2.50.8-0.6-0.40.2-1.4-1.5-1.5-2.0
Bone: trabecular spacing1.11.54.20.11.8-1.60.5-0.40.41.21.21.22.1
Bone: trabecular thickness0.81.02.9-0.2-1.51.1-0.10.2-0.2-1.0-1.0-1.0-1.7
Bone: trabecular tissue density0.50.82.0-0.91.0-1.4-0.8-0.5-0.70.50.50.51.4
Water consumed over 24 hours0.91.24.11.90.30.90.32.0-1.0-0.5-0.5-0.5-1.0
Number of responses in last shaping day0.40.41.20.3-0.00.9-0.30.9-1.1-0.5-0.4-0.5-0.8