Hub : Genes

Card14

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	mRNA stability	Card14	0.04	0.03	4.2e-04	0.05	0.04	0.01	0.04	2.4e-05	7.2e-05	3.4e-02	5.9e-05
2	Eye	isoform ratio	XM_039087522.2	0.31	0.17	9.0e-03	0.04	0.1	-0.02	0.01	9.5e-02	1.1e-02	9.2e-01	2.1e-01
3	Eye	intron excision ratio	chr10_105080755_105082541	0.29	0.17	9.4e-03	0.06	0.02	0.04	0.06	4.0e-02	1.8e-01	7.7e-02	4.1e-02
4	Liver	alternative TSS	XM_039087524.2	0.03	0.02	3.1e-03	0.02	0.02	0.01	0.02	1.1e-03	5.9e-03	5.5e-02	2.8e-03
5	PL	gene expression	Card14	0.04	0.02	1.2e-04	0	0.03	0.02	0.01	9.5e-02	2.8e-04	1.6e-03	7.4e-03
6	PL	alternative polyA	NM_001427162.1	0.02	0.02	6.2e-03	0.02	0.01	0.01	0.01	6.9e-03	1.2e-02	1.9e-02	3.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.2	0.4	0.9	0.2	-0.6	-0.2	0.4	-0.9	-1.0
Area under the delay curve	1.8	2.1	3.4	-1.0	1.7	1.5	-1.1	1.2	1.8
BMI with tail	0.5	1.8	3.0	1.4	-1.7	-1.4	1.6	-1.1	-0.1
BMI without tail	2.1	6.3	11.2	3.1	-3.3	-3.0	2.5	-1.4	-0.3
Body weight	1.9	8.4	17.9	4.2	-3.0	-3.9	2.1	0.4	1.8
Weight adjusted by age	1.9	2.9	5.9	2.2	-1.9	-2.4	1.5	0.2	0.9
Bone surface	0.1	0.2	0.7	0.3	0.3	-0.2	-0.6	0.8	0.2
Bone volume	0.1	0.1	0.5	0.4	-0.3	-0.3	-0.0	-0.1	-0.7
Breakpoint value in progressive ratio session	0.6	0.8	1.3	0.8	-1.1	-0.8	1.1	-0.8	-0.3
Number of licking bursts	0.1	0.1	0.3	0.4	-0.3	-0.6	-0.1	0.1	0.4
Context. condit. distance diff. score	1.1	1.3	3.1	0.9	-1.2	-0.7	1.8	-1.2	-0.6
Locomotion velocity, session 1	4.6	5.0	8.5	-2.2	2.9	2.1	-2.5	2.1	1.2
Locomotion distance, session 1	1.1	1.3	3.0	-1.7	0.8	1.7	-0.0	-1.0	-0.7
Locomotion velocity, session 2	3.8	4.4	7.6	-2.7	2.4	2.8	-2.3	0.5	-0.4
Locomotion distance, session 2	0.8	1.0	2.7	-0.7	-0.4	0.7	0.8	-1.7	-1.3
Locomotion velocity, session 3	1.6	1.9	3.4	-1.3	1.8	1.5	-1.4	1.2	0.6
Locomotion distance, session 3	2.1	2.3	4.6	-2.1	1.8	2.2	-1.2	0.1	-0.1
Stereotopy head waving bouts, day 3	0.4	0.5	0.9	-0.5	0.9	0.6	-0.7	0.9	0.1
Stereotopy head waving duration, day 3	0.2	0.2	0.5	-0.4	0.7	0.5	-0.2	0.6	-0.3
Locomotion velocity, session 7	0.5	0.6	1.4	-1.2	1.0	1.0	-0.1	0.1	-0.2
Locomotion distance, session 7	2.2	2.7	5.2	-2.0	0.6	1.9	0.2	-1.8	-2.3
Stereotopy head waving bouts, day 7	0.4	0.4	1.0	1.0	-0.3	-0.7	0.7	0.5	0.6
Stereotopy head waving duration, day 7	0.7	0.8	1.3	1.1	-0.2	-1.0	0.4	1.0	1.1
Locomotion velocity, session 8	0.2	0.2	0.7	-0.4	0.3	0.6	0.8	-0.2	-0.3
Locomotion distance, session 8	2.7	3.8	7.8	0.5	-1.9	-0.4	2.6	-2.8	-2.0
Degree of sensitization distance	2.0	2.1	3.1	0.8	-1.7	-0.9	1.5	-1.7	-1.8
Degree of sensitization stereotypy	0.6	0.7	1.2	1.1	-0.8	-0.9	1.1	-0.2	0.3
Conditioned locomotion	3.8	4.3	7.3	2.4	-2.7	-2.3	2.4	-1.5	-0.3
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.4	0.4	0.5	-0.1	0.2	0.0
Cocaine response after cond. not corrected	0.6	0.7	1.4	-1.0	1.2	1.0	-0.7	0.6	0.1
Cocaine response before conditioning	0.6	0.7	1.4	-1.0	1.2	0.9	-0.9	0.6	0.2
Saline control response	1.4	1.9	4.0	1.9	-1.4	-2.0	1.0	0.3	0.7
Bone: connectivity density	0.1	0.1	0.5	-0.4	-0.1	0.3	0.2	-0.7	-0.4
Bone: cortical apparent density	1.6	2.2	4.8	-2.2	1.2	2.1	-1.0	-0.8	-0.9
Bone: cortical area	3.6	5.5	11.2	3.3	-1.9	-3.1	1.1	1.1	2.4
Bone: cortical porosity	0.8	0.9	2.7	0.6	0.4	-0.6	-1.1	1.6	0.8
Bone: cortical porosity	0.9	1.0	2.5	1.0	0.1	-1.0	-0.6	1.6	1.1
Bone: cortical thickness	3.1	5.2	10.4	3.2	-2.1	-3.0	1.0	0.6	2.4
Bone: cortical thickness	1.2	1.4	2.3	1.5	-1.1	-1.3	0.8	0.0	1.5
Bone: cortical tissue density	1.8	2.5	5.4	-2.3	1.3	2.2	-1.1	-0.7	-1.0
Condit. Reinf. active minus inactive responses	1.9	2.1	3.6	1.8	-1.9	-1.8	1.4	-0.8	0.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.4	1.2	-1.5	-1.2	1.2	-1.0	-0.0
Condit. Reinf. active responses	3.1	3.8	6.2	2.5	-2.5	-2.5	1.8	-0.9	0.5
Condit. Reinf. inactive responses	0.7	0.8	1.4	1.1	-1.1	-1.2	0.9	-0.4	0.1
Incentive salience index mean	1.6	1.9	3.1	1.7	-1.7	-1.8	1.4	-0.6	0.7
Condit. Reinf. lever presses	0.3	0.4	0.9	0.3	-0.7	-0.5	0.9	-0.7	-0.2
Condit. Reinf. active minus inactive responses	0.6	0.8	1.6	0.9	-0.7	-0.9	1.1	0.1	1.2
Condit. Reinf. active-inactive response ratio	1.3	1.5	2.6	1.5	-1.0	-1.6	0.8	0.6	1.4
Condit. Reinf. active responses	0.5	0.6	1.8	0.3	-0.9	-0.3	1.3	-1.0	-0.0
Condit. Reinf. inactive responses	0.7	1.0	2.3	-0.7	-0.1	1.0	0.5	-1.5	-1.3
Condit. Reinf. lever presses	1.6	2.3	4.6	0.6	-1.7	-0.6	1.7	-2.1	-1.5
Condit. Reinf. lever reinforcers received	0.9	1.3	3.2	0.4	-1.2	-0.3	1.8	-1.6	-0.5
Conditioned reinforcement - actives	0.3	0.5	1.9	-0.2	-0.4	-0.2	0.4	-0.8	-1.4
Conditioned reinforcement - inactives	0.5	0.7	1.2	1.1	-1.0	-1.1	0.7	-0.1	-0.5
Conditioned locomotion	1.0	1.3	2.1	0.7	-1.3	-0.9	1.1	-1.1	-1.5
Patch foraging indifference point 0 sec	1.0	1.9	3.2	0.9	-1.7	-0.6	1.0	-1.8	-1.7
Patch foraging indifference point AUC	0.1	0.1	0.2	0.5	-0.5	-0.1	0.3	-0.4	-0.2
Delay disc. indifference point, 0s delay	0.5	0.5	1.7	0.4	0.3	-0.5	0.3	0.9	1.3
Delay disc. indifference point, 16s delay	0.4	0.4	1.4	-0.7	0.4	1.2	-0.2	-0.7	-0.0
Delay disc. indifference point, 2s delay	0.9	1.0	3.0	0.0	0.9	0.6	-0.8	1.2	1.7
Delay disc. indifference point, 24s delay	4.0	4.5	7.5	-2.3	2.5	2.7	-2.5	1.0	1.0
Delay disc. indifference point, 4s delay	1.0	1.0	3.7	0.2	0.9	0.6	-0.4	1.2	1.9
Delay disc. indifference point, 8s delay	3.2	3.8	6.9	-1.1	2.2	1.3	-1.5	2.3	2.6
Indifference point function ln k	0.6	1.1	2.5	-1.3	0.5	1.1	-0.2	-0.8	-1.6
Indifference point function log k	0.6	1.1	2.5	-1.3	0.5	1.1	-0.2	-0.8	-1.6
Patch foraging total patch changes 0 sec	1.4	2.7	4.9	1.0	-2.0	-0.7	1.4	-2.2	-2.0
Patch foraging total patch changes 12 sec	0.7	0.9	1.7	1.0	-1.3	-0.3	0.4	-1.3	-0.9
Patch foraging total patch changes 18 sec	1.2	1.8	4.8	0.7	-1.5	0.1	1.3	-2.2	-1.2
Patch foraging total patch changes 24 sec	1.1	1.9	3.2	1.8	-1.8	-1.6	1.4	-0.8	0.3
Patch foraging total patch changes 6 sec	0.6	1.0	2.2	1.4	-1.5	-0.9	0.2	-0.8	-0.4
Patch foraging time to switch 0 sec	0.7	1.5	2.3	-1.2	1.5	1.2	-1.3	0.9	1.1
Patch foraging water rate 0 sec	3.1	6.5	10.7	2.7	-3.3	-2.6	2.9	-2.0	-1.4
Patch foraging water rate 12 sec	1.7	3.5	5.8	0.5	-1.9	-0.9	2.2	-2.4	-2.2
Patch foraging water rate 18 sec	2.8	4.4	6.3	1.5	-2.4	-1.7	2.5	-2.0	-2.3
Patch foraging water rate 24 sec	7.8	10.9	17.0	2.6	-3.9	-2.2	4.1	-3.5	-3.0
Patch foraging water rate 6 sec	0.8	1.1	2.2	0.4	-1.1	-0.7	1.5	-1.2	-1.0
Seeking ratio, delayed vs. immediate footshock	0.7	0.9	3.0	0.7	-0.5	-1.1	0.4	0.7	1.7
Distance traveled before self-admin	0.7	0.9	2.0	1.4	-0.9	-1.2	0.9	0.3	0.5
Distance traveled after self-admin	2.3	2.8	4.0	1.2	-2.0	-1.3	1.9	-1.8	-1.7
Extensor digitorum longus weight	0.8	3.0	7.3	0.3	-1.9	-0.4	2.0	-2.7	-1.7
Bone: elastic displacement	1.4	1.7	3.0	1.6	-1.7	-1.5	1.2	-0.9	-0.2
Bone: elastic work	3.7	4.8	10.9	3.3	-2.3	-3.1	1.1	0.4	1.3
Bone: endosteal estimation	0.0	0.1	0.3	-0.1	-0.0	0.2	0.3	-0.3	-0.5
Bone: endosteal perimeter	0.6	1.3	2.9	1.2	0.2	-1.0	-0.5	1.7	1.5
Epididymis fat weight	1.2	4.2	6.5	2.2	-2.5	-2.4	2.6	-1.2	-0.3
Delta time in closed arm before/after self-admin	0.2	0.2	0.9	0.2	-0.1	-0.1	0.0	0.0	1.0
Delta time in open arm before/after self-admin	0.5	0.5	0.8	0.7	-0.9	-0.3	0.5	-0.8	-0.9
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	0.6	-0.4	-0.3	-0.0	0.2	0.5
Delay discount exponential model param	2.6	2.9	4.1	1.2	-2.0	-1.9	1.5	-1.4	-2.0
Extinction: sum of active levers before priming	0.4	0.4	1.0	-0.7	0.1	0.6	-0.1	-0.7	-1.0
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	-0.1	0.1	-0.3	0.1	0.3
Bone: final force	3.4	5.5	11.2	3.3	-2.3	-3.1	1.7	0.5	1.8
Bone: final moment	3.9	6.2	12.9	3.6	-2.5	-3.4	1.8	0.5	1.7
Food consumed during 24 hour testing period	0.8	1.1	1.9	1.2	-1.3	-1.2	1.4	-0.6	-0.2
Glucose	6.4	10.0	15.9	-3.5	4.0	3.6	-3.8	2.1	0.4
Heart weight	0.4	0.6	1.5	0.7	-0.7	-1.2	0.6	0.4	0.9
Delay discount hyperbolic model param	2.4	2.7	4.1	1.0	-1.9	-1.8	1.5	-1.4	-2.0
Intermittent access intake day 1-15 change	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	0.4	0.2
Intermittent access intake escalation	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.1	0.3	0.1
Intermittent access intake escalation 2	0.2	0.2	0.5	0.2	-0.0	-0.5	-0.1	0.7	0.5
Intermitt. access day 1 inactive lever presses	1.2	4.5	7.6	2.5	-2.8	-2.3	2.2	-1.4	-1.0
Intermitt. access day 15 inactive lever presses	1.1	2.2	3.7	1.4	-1.8	-1.5	1.9	-1.3	-0.5
Intermitt. access escalation Index	0.6	0.8	1.1	1.0	-1.1	-1.1	0.9	-0.4	0.7
Intermittent access day 1 total infusions	0.3	0.4	1.0	0.4	-0.7	-0.3	0.6	-0.8	-1.0
Intermittent access day 15 total infusions	0.3	0.4	0.7	0.7	-0.9	-0.7	0.5	-0.4	-0.4
Intermittent access terminal intake (last 3 days)	0.3	0.4	0.8	0.7	-0.8	-0.9	0.6	-0.1	-0.1
Intermittent access total infusions	0.2	0.3	0.5	0.5	-0.7	-0.5	0.6	-0.5	-0.3
Intermittent access day 1 locomotion	0.3	0.3	0.5	0.4	-0.7	-0.4	0.5	-0.6	-0.7
Intermittent access day 15 total locomotion	0.3	0.5	0.9	0.9	-0.9	-1.0	0.7	-0.2	-0.5
Intermittent access total locomotion	0.4	0.5	0.8	0.7	-0.9	-0.6	0.7	-0.5	-0.9
Intermittent access standard deviation	0.5	1.0	2.2	-0.5	1.1	0.5	-0.5	1.3	1.5
Left kidney weight	0.3	1.3	3.4	0.6	0.7	-0.4	-0.6	1.8	1.8
Right kidney weight	0.2	0.9	3.3	0.5	0.4	-0.3	-0.4	1.3	1.8
Cocaine induced anxiety	1.0	1.5	4.0	1.3	-0.4	-1.2	-0.1	1.3	2.0
Post-drug Anxiety	0.2	0.2	0.4	0.5	0.1	0.1	-0.7	0.7	0.5
Baseline Anxiety	1.5	1.8	3.5	-1.3	0.9	1.7	-1.0	-0.6	-1.9
Tail length	2.3	9.1	19.6	4.4	-3.1	-4.2	2.0	0.8	1.8
Length with tail	1.7	7.3	12.7	3.6	-1.3	-3.2	0.5	2.7	3.4
Length without tail	1.0	3.3	10.3	1.3	0.4	-1.1	-0.6	2.4	3.2
Times rat made contact with spout	0.8	0.9	2.0	1.3	-1.1	-1.4	0.5	-0.1	-0.1
Lifetime Intake	0.1	0.1	0.2	0.1	-0.4	-0.1	0.5	-0.5	-0.3
Liver weight, left	0.7	1.2	2.1	-0.7	1.5	0.8	-1.3	1.5	0.4
Liver weight, right	2.4	4.1	8.6	2.9	-1.8	-2.7	1.4	0.7	1.7
Locomotor activity	0.4	0.6	1.3	-0.8	0.7	0.9	-0.4	-0.1	-1.1
Locomotor testing distance	0.4	0.7	2.0	-0.9	0.5	1.1	0.1	-0.5	-1.4
Locomotor testing rearing	0.7	1.3	2.5	0.4	-1.0	-0.1	1.4	-1.6	-1.5
Locomotion in novel chamber	0.2	0.3	0.4	0.7	-0.6	-0.3	0.4	-0.5	-0.6
Locomotion in novel chamber post-restriction	0.5	0.8	1.9	1.1	-1.0	-1.4	0.5	0.2	-0.8
Fecal boli incidents, locomotor time 1	0.2	0.3	1.3	-1.1	0.3	0.7	0.0	-0.5	-0.2
Change in fecal boli incidents, locomotor task	2.4	2.3	4.2	-1.5	1.7	2.0	-2.0	0.5	-0.6
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.0	-0.1	-0.4	-0.1	1.0	-0.9	-0.6
Bouts of movement, locomotor time 1	1.4	1.6	3.5	-1.9	1.2	1.8	-1.1	-0.2	-0.1
Total resting periods, locomotor time 1	1.9	2.1	4.3	-2.1	1.4	2.0	-1.4	-0.1	-0.5
Rest time, locomotor task time 1	0.8	1.0	1.5	-1.1	1.1	1.0	-1.2	0.8	-0.2
Distance moved, locomotor task time 1	0.5	0.7	1.4	1.2	-1.0	-1.1	0.6	-0.2	0.5
Vertical activity count, locomotor time 1	0.6	1.4	2.2	1.1	-1.4	-1.5	1.5	-0.9	-0.1
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.5	-0.1	-0.0	-0.3	0.1	-0.0
Bouts of movement, locomotor time 2	0.6	1.0	2.4	-1.4	1.1	1.5	-0.8	-0.0	-0.1
Total resting periods, locomotor time 2	0.3	0.6	1.3	-1.1	0.8	1.1	-0.4	-0.1	-0.0
Rest time, locomotor task time 2	0.2	0.2	0.4	-0.6	0.5	0.5	-0.5	0.3	0.2
Distance moved, locomotor task time 2	0.3	0.3	0.7	0.9	-0.3	-0.5	0.0	0.4	0.8
Vertical activity count, locomotor time 2	0.2	0.3	0.6	0.6	-0.6	-0.5	0.8	-0.4	0.1
Light reinforcement 1	1.8	4.5	7.3	1.9	-2.7	-2.1	2.5	-2.1	-1.1
Light reinforcement 2	1.6	2.5	5.2	1.9	-1.7	-2.3	1.6	-0.3	0.6
Bone: marrow area	0.0	0.1	0.3	-0.1	-0.0	0.2	0.3	-0.3	-0.5
Bone: maximum diameter	1.5	2.9	6.1	1.9	-0.2	-1.8	-0.2	2.1	2.5
Bone: maximum force	3.0	5.4	11.5	3.4	-2.4	-3.2	1.7	0.4	1.5
Bone: maximum moment	3.4	5.9	12.7	3.6	-2.5	-3.4	1.8	0.4	1.3
Mean time between licks in bursts	0.5	1.1	2.5	-1.3	1.3	1.6	-0.9	0.4	-0.2
Mean num. licks in bursts	0.3	0.4	0.7	0.5	-0.8	-0.5	0.7	-0.7	-0.7
Cd content in liver	1.6	1.8	5.0	-0.3	-1.0	0.4	1.3	-2.2	-1.7
Co content in liver	0.1	0.1	0.1	0.2	-0.4	-0.3	0.0	-0.3	-0.2
Cu content in liver	0.3	0.4	0.9	0.9	-0.4	-1.0	0.1	0.6	0.4
Fe content in liver	0.3	0.3	1.1	-0.1	-0.1	0.3	0.6	-0.6	-1.1
K content in liver	1.7	1.6	2.7	1.3	-1.6	-1.6	1.5	-0.8	-0.0
Mg content in liver	1.5	1.5	2.8	0.3	-1.4	-0.8	1.7	-1.6	-1.2
Mn content in liver	0.1	0.1	0.4	0.4	0.1	-0.3	0.2	0.5	0.6
Na content in liver	0.0	0.0	0.2	-0.0	-0.1	-0.2	0.4	-0.1	-0.0
Rb content in liver	2.9	3.3	6.2	1.6	-2.3	-1.7	2.5	-1.7	-0.6
Se content in liver	0.6	0.7	1.4	0.5	-0.9	-0.6	1.2	-0.9	-0.6
Sr content in liver	0.5	0.5	1.7	-0.4	0.6	0.7	-1.3	0.5	-0.1
Zn content in liver	0.7	0.8	1.9	1.2	-1.0	-1.4	0.8	0.0	0.2
Bone: minimum diameter	2.2	3.9	9.6	3.1	-1.9	-2.7	1.1	0.6	1.1
Time in familiar zone, hab. session 1	0.3	0.3	1.2	-0.1	-0.3	0.3	0.1	-0.7	-1.1
Time in novel zone, hab. session 1	0.2	0.2	0.8	0.1	0.3	-0.1	0.2	0.7	0.9
Total zone transitions, hab. session 1	0.5	0.7	1.6	-0.4	-0.4	0.5	0.7	-1.3	-1.1
Total locomotion distance, hab. session 1	1.2	1.7	3.4	0.7	-1.5	-0.7	1.8	-1.7	-0.9
Locomotion velocity, hab. session 1	1.2	1.7	3.0	0.7	-1.6	-0.7	1.7	-1.7	-0.9
Time in familiar zone, hab. session 2	0.4	0.4	1.1	-0.4	-0.0	0.5	0.4	-0.7	-1.1
Time in novel zone, hab. session 2	0.2	0.2	0.5	-0.1	0.4	0.2	-0.5	0.5	0.7
Total zone transitions, hab. session 2	1.9	2.4	5.9	-0.3	-1.3	0.2	1.5	-2.4	-2.1
Total locomotion distance, hab. session 2	2.5	3.3	6.2	0.8	-2.1	-0.9	2.2	-2.5	-1.6
Locomotion velocity, hab. session 2	2.4	3.2	5.5	1.0	-2.2	-1.1	2.2	-2.3	-1.3
Novel to familiar place preference ratio	2.1	2.2	4.8	1.6	-2.2	-1.5	1.2	-1.5	-0.4
Novelty place preference	1.8	1.9	4.1	1.6	-2.0	-1.5	1.1	-1.3	-0.3
Time in novel zone, NPP test	1.9	2.0	4.2	1.5	-2.0	-1.4	1.1	-1.5	-0.6
Total zone transitions, NPP test	1.1	1.6	4.0	-0.4	-0.9	0.4	1.4	-2.0	-1.5
Total locomotion distance, NPP test	3.1	4.3	9.3	0.5	-2.2	-0.5	2.4	-3.1	-2.3
Locomotion velocity, NPP test	2.6	3.7	7.6	0.6	-2.1	-0.7	2.3	-2.8	-1.9
Intraocular pressure	0.9	1.3	2.6	1.0	-1.6	-0.6	1.1	-1.6	-0.6
Delta distance traveled before/after self-admin	1.1	1.2	3.0	-0.2	-0.9	-0.1	0.8	-1.7	-1.6
Delta ambulatory time before/after self-admin	0.9	1.2	2.9	-0.9	-0.3	0.6	0.3	-1.7	-1.7
Parametrial fat weight	0.7	1.7	2.3	1.4	-1.5	-1.3	1.2	-0.8	-1.4
Pavlov. Cond. lever latency	1.4	1.7	3.2	-1.1	-0.1	1.1	1.2	-1.8	-1.8
Pavlov. Cond. magazine entry latency	1.7	2.2	3.8	1.8	-0.5	-1.8	-0.1	1.7	2.0
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.4	-0.4	-0.3	0.0	0.3
Pavlov. Cond. index score	2.2	2.7	5.0	2.2	-1.0	-2.2	-0.0	1.5	1.9
Pavlov. Cond. latency score	2.0	2.5	4.0	1.9	-0.5	-1.9	-0.5	1.9	2.0
Pavlov. Cond. lever contacts	0.6	0.7	1.3	1.1	-0.5	-1.1	-0.4	0.9	0.9
Pavlov. Cond. magazine entry number	1.7	2.1	3.5	-1.6	0.3	1.6	0.6	-1.8	-1.9
Pavlov. Cond. intertrial magazine entries	0.8	1.0	2.6	0.2	-1.1	-0.3	1.0	-1.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	2.1	2.5	5.0	2.2	-1.2	-2.2	0.2	1.1	1.6
Pavlov. Cond. response bias	1.4	1.7	2.9	1.5	-0.3	-1.5	-0.6	1.6	1.7
Pavlov. Cond. lever latency	2.5	3.4	5.5	-1.4	2.4	1.4	-2.2	2.1	1.2
Pavlov. Cond. magazine entry latency	1.5	1.9	4.6	-0.8	-0.4	1.0	0.7	-2.1	-2.1
Pavlov. Cond. change in total contacts	1.2	2.0	5.7	-0.1	-1.2	0.2	1.5	-2.4	-1.6
Pavlov. Cond. index score	1.7	2.2	5.4	0.3	-1.5	-0.1	1.6	-2.3	-1.7
Pavlov. Cond. latency score	1.5	2.0	4.9	0.3	-1.4	-0.2	1.6	-2.2	-1.6
Pavlov. Cond. lever contacts	2.4	3.4	5.3	1.2	-2.3	-1.2	2.2	-2.3	-1.5
Pavlov. Cond. magazine entry number	1.4	1.7	4.7	0.5	0.7	-0.7	-1.2	2.2	1.8
Pavlov. Cond. intertrial magazine entries	1.0	1.5	2.6	1.6	-1.2	-1.6	1.3	0.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	5.1	0.0	-1.2	0.1	1.5	-2.3	-1.8
Pavlov. Cond. response bias	1.9	2.6	6.0	0.4	-1.7	-0.3	1.8	-2.5	-1.9
Time in closed arm before self-admin	0.9	1.1	2.0	-0.8	1.2	1.3	-1.4	0.8	0.2
Time in closed arm after self-admin	1.7	1.8	3.4	-1.1	1.4	1.7	-1.8	0.8	0.7
Time in open arm before self-admin	0.2	0.2	0.5	0.2	-0.0	-0.7	0.4	0.2	0.7
Time in open arm after self-admin	0.6	0.6	1.5	0.4	-0.8	-0.5	0.7	-0.8	-1.2
Bone: periosteal estimation	0.9	2.0	4.3	2.1	-1.1	-1.8	0.7	0.7	1.3
Bone: periosteal perimeter	2.9	5.0	9.7	2.5	-0.2	-2.2	-0.8	2.9	3.1
Bone: post-yield work	0.1	0.1	0.5	-0.1	-0.3	0.1	0.1	-0.7	-0.2
Progressive ratio test 1 active lever presses	0.4	0.4	0.7	0.3	-0.8	-0.5	0.8	-0.8	-0.7
Progressive ratio test 1 breakpoint	0.3	0.4	0.6	0.3	-0.8	-0.5	0.8	-0.8	-0.6
Progressive ratio test 1 inactive lever presses	3.5	5.0	7.8	2.6	-2.8	-2.6	2.6	-1.4	-0.3
Progressive ratio test 2 active lever presses	0.5	0.6	1.3	0.4	-0.8	-0.4	0.6	-0.9	-1.1
Progressive ratio test 2 breakpoint	0.5	0.5	1.1	0.4	-0.8	-0.4	0.6	-0.8	-1.1
Progressive ratio test 2 inactive lever presses	0.3	0.4	0.8	0.9	-0.8	-0.9	0.6	-0.1	-0.2
Incentive Sensitization - Responses	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.1	-0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3	-0.1	-0.3
Sum of active levers in priming session hrs 5-6	0.6	0.6	1.1	0.2	-0.8	-0.6	1.0	-1.0	-0.5
Progressive ratio	0.4	0.6	1.6	-1.3	0.5	1.0	-0.7	-0.5	-0.0
Food seeking constrained by brief footshock	0.3	0.3	0.5	-0.7	0.6	0.3	-0.4	0.4	0.7
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.4	-0.1	-0.4	0.5	0.2	0.1
Retroperitoneal fat weight	3.7	15.7	23.8	4.7	-4.9	-4.8	4.6	-2.0	-0.4
Reaction time number correct	3.1	5.9	10.6	0.9	-2.5	-0.9	3.1	-3.3	-2.7
Reaction time mean minus median	0.3	0.7	1.3	-0.4	1.0	0.6	-1.1	1.1	0.5
Reaction time mean minus median AUC	0.3	0.6	1.5	0.5	0.4	-0.2	-0.8	1.2	1.2
Reaction time num false alarms	0.2	0.2	0.5	-0.4	0.3	0.6	-0.5	-0.1	-0.7
Reaction time num false alarms AUC	0.3	0.4	0.8	-0.6	0.5	0.9	-0.7	-0.2	-0.8
Reaction time trials correct on left	3.1	5.9	10.6	0.9	-2.5	-0.9	3.1	-3.3	-2.7
Reaction time trials on left	3.2	5.9	10.6	0.9	-2.5	-0.9	3.1	-3.3	-2.7
Reaction time mean	0.1	0.2	0.3	0.5	-0.6	-0.4	0.6	-0.4	-0.1
Reaction time mean AUC	0.2	0.3	0.5	0.5	-0.7	-0.5	0.7	-0.6	-0.3
Median of all reaction times	0.3	0.5	0.9	0.6	-0.8	-0.6	1.0	-0.7	-0.2
Reaction time omissions	0.4	0.6	1.5	0.9	-0.2	-0.8	0.2	0.7	1.2
Reaction time false alarm rate	1.6	2.2	4.5	-1.1	1.8	1.3	-2.1	1.5	0.5
Reaction time premature initiation rate	1.2	1.6	3.1	-1.2	0.5	1.8	-0.8	-1.1	-1.7
Reaction time premature initiations	2.0	3.5	9.3	-0.6	-1.0	1.0	1.0	-2.9	-3.0
Std. dev. reaction times	0.1	0.3	0.6	-0.5	0.5	0.8	-0.6	-0.1	-0.2
Reaction time trials completed	3.2	5.9	10.6	0.9	-2.5	-0.9	3.1	-3.3	-2.7
Reaction time trials AUC	3.4	6.4	11.5	1.0	-2.6	-1.0	3.2	-3.4	-2.8
Run reversals in cocaine runway, females	0.5	0.5	1.2	-0.6	0.2	1.1	0.0	-0.9	-0.8
Run reversals in cocaine runway, males	0.2	0.2	0.5	0.3	-0.2	-0.7	-0.2	0.6	0.1
Latency to leave start box in cocaine runway	0.5	0.6	1.4	-1.2	0.6	0.7	-0.4	-0.4	-1.1
Latency to leave start box in cocaine runway, F	0.5	0.6	1.7	-0.3	-0.4	0.1	0.5	-1.1	-1.3
Latency to leave start box in cocaine runway, M	0.7	0.6	1.7	-1.3	1.0	0.7	-0.6	0.3	-0.5
Std. dev. time between licks in bursts	1.7	2.3	4.6	0.9	-1.7	-0.7	2.1	-1.8	-1.4
Total sessions with >9 infusions	0.2	0.3	0.8	-0.9	0.5	0.6	-0.0	-0.2	-0.1
Short access day 1 total inactive lever presses	0.2	0.3	0.5	0.5	-0.0	-0.5	0.4	0.7	0.7
Short access day 10 total inactive lever presses	1.6	4.0	8.4	2.9	-2.4	-2.5	1.8	-0.3	0.4
Short access day 1 total infusions	0.7	0.9	2.1	-1.2	0.9	1.4	-0.5	-0.4	-0.7
Short access day 10 total infusions	0.6	0.7	1.3	0.9	-1.0	-1.1	1.0	-0.2	-0.2
Short access total infusions	0.2	0.2	0.6	-0.1	-0.3	0.0	0.6	-0.7	-0.4
Short access day 1 locomotion	0.5	0.6	1.0	-1.0	1.0	0.8	-0.7	0.5	-0.1
Short access day 10 total locomotion	0.3	0.6	1.0	-0.8	1.0	0.5	-0.9	1.0	0.3
Short access total locomotion	0.5	0.6	0.9	-0.8	0.9	0.3	-0.6	1.0	0.8
One hour access (0.3 mA shock)	0.7	0.8	1.8	0.3	-1.0	-0.4	0.9	-1.4	-1.1
Compulsive drug intake	0.6	0.7	1.0	1.0	-1.0	-0.9	1.0	-0.6	0.2
One hour access (shock baseline)	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.1	-0.2	-0.5
Social response proportion	0.1	0.1	0.4	0.1	-0.3	0.3	0.2	-0.6	0.1
Social responses	0.1	0.2	0.4	0.5	-0.6	-0.1	0.4	-0.5	0.2
Social time	0.1	0.2	0.6	-0.1	-0.4	0.0	0.5	-0.8	0.2
Soleus weight	0.8	2.5	5.5	2.2	-2.0	-2.3	0.6	-0.1	0.8
Bone: stiffness	0.4	0.6	1.5	0.8	-0.1	-0.7	0.2	0.8	1.2
Tibialis anterior weight	0.1	0.2	0.4	-0.4	-0.2	0.4	-0.3	-0.6	-0.5
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.6	-0.2	0.6	0.5	-0.8	0.5	0.0
Time to tail flick, vehicle, after self-admin	1.3	1.7	2.6	-1.2	1.6	1.4	-1.5	1.1	0.8
Time to tail flick, test, before self-admin	0.6	0.6	1.4	-0.9	0.9	0.8	-1.2	0.5	-0.1
Time to tail flick, test, after self-admin	1.6	1.7	4.6	-0.4	1.3	0.9	-1.1	1.3	2.1
Delta time to tail flick, vehicle, before/after SA	0.3	0.2	0.4	0.5	-0.6	-0.5	0.6	-0.4	0.2
Delta time to tail flick, test, before/after SA	0.8	0.8	2.0	-0.4	1.0	0.7	-0.5	1.0	1.4
Tibia length	6.9	19.1	36.7	5.1	-1.6	-5.3	1.2	4.4	6.1
Ambulatory time before self-admin	1.7	2.5	5.2	2.3	-1.6	-2.0	1.6	0.2	0.7
Ambulatory time after self-admin	2.1	2.5	3.6	1.4	-1.9	-1.3	1.9	-1.6	-1.2
Bone: tissue strength	2.9	2.9	5.2	1.9	-2.3	-1.9	1.7	-1.3	-0.7
Total heroin consumption	0.3	0.4	1.2	0.3	-0.1	-0.7	0.6	0.4	1.1
Bone: trabecular number	0.1	0.2	0.5	-0.4	0.5	0.4	-0.7	0.3	0.0
Bone: trabecular spacing	2.2	2.9	7.8	1.2	-1.9	-1.1	2.8	-1.8	-0.6
Bone: trabecular thickness	0.2	0.3	1.2	0.1	0.2	-0.3	-1.1	0.7	0.1
Bone: trabecular tissue density	0.6	0.9	1.7	-0.8	1.3	1.0	-0.9	0.8	0.8
Water consumed over 24 hours	0.1	0.1	0.5	-0.1	0.3	-0.0	-0.7	0.5	-0.1
Number of responses in last shaping day	0.2	0.2	0.6	-0.0	0.3	-0.4	0.1	0.7	0.8