Hub : Genes

Capn12

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Capn12 0.05 0.03 1.5e-08 0.05 0.05 0.05 0.06 8.8e-08 9.9e-08 1.5e-08 5.3e-09
2 Adipose gene expression Capn12 0.04 0.03 2.7e-03 0.01 0 0 0 1.7e-02 8.9e-02 1.1e-01 8.0e-02
3 pVTA gene expression Capn12 0.06 0.05 1.6e-04 0.04 0.01 0.04 0.01 3.2e-04 2.0e-02 5.9e-04 5.2e-02
4 Brain gene expression Capn12 0.05 0.04 1.1e-04 0.02 0.03 0.03 0.03 7.7e-03 3.7e-04 6.1e-04 1.2e-03
5 PL gene expression Capn12 0.04 0.03 6.4e-05 0.04 0.01 0.04 0 9.7e-05 1.8e-02 9.5e-05 1.6e-01
6 PL alternative polyA NM_001110808.1 0.04 0.03 5.1e-03 0 0.01 0.02 0.01 2.4e-01 3.2e-02 4.4e-03 1.7e-02
7 PL alternative polyA NM_001110808.1 0.04 0.03 3.2e-03 0 0 0.02 0.01 8.8e-02 1.1e-01 1.8e-03 2.1e-02
8 PL alternative polyA XM_039111580.2 0.03 0.02 3.5e-03 0.01 0.01 0.02 0.01 1.3e-02 4.8e-02 2.8e-03 7.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.20.30.8-0.1-0.2-0.10.5-0.20.80.4-0.9
Area under the delay curve0.20.20.80.2-0.1-0.1-0.40.4-0.9-0.60.5
BMI with tail0.10.41.0-0.4-0.2-0.3-1.00.1-0.8-0.60.9
BMI without tail0.41.21.81.31.31.21.21.3-0.6-0.70.6
Body weight1.56.411.13.33.03.13.32.9-0.8-1.20.7
Weight adjusted by age0.10.10.40.00.20.2-0.30.1-0.5-0.50.7
Bone surface0.40.72.20.80.60.61.50.60.80.1-0.9
Bone volume0.40.62.10.90.70.71.50.60.60.2-0.7
Breakpoint value in progressive ratio session3.23.87.41.31.31.4-0.41.8-2.7-2.72.7
Number of licking bursts1.62.75.1-1.7-1.4-1.3-0.4-1.92.21.4-2.0
Context. condit. distance diff. score0.00.00.1-0.30.0-0.0-0.4-0.2-0.0-0.00.2
Locomotion velocity, session 11.51.63.6-1.7-1.5-1.4-1.9-1.3-0.00.2-0.1
Locomotion distance, session 10.40.61.10.91.01.00.90.7-0.3-0.20.3
Locomotion velocity, session 20.20.30.5-0.7-0.6-0.6-0.6-0.60.30.3-0.2
Locomotion distance, session 20.50.61.9-0.9-0.8-0.8-1.4-0.4-0.6-0.50.7
Locomotion velocity, session 32.22.56.0-0.4-0.3-0.31.1-1.42.32.4-2.2
Locomotion distance, session 34.24.58.12.72.92.82.82.1-0.4-0.50.5
Stereotopy head waving bouts, day 30.30.31.0-0.7-0.5-0.4-1.0-0.4-0.3-0.50.5
Stereotopy head waving duration, day 31.41.73.2-1.8-1.7-1.6-1.7-1.30.40.3-0.3
Locomotion velocity, session 70.40.51.10.10.0-0.10.8-0.31.01.1-1.0
Locomotion distance, session 70.30.30.90.40.30.31.00.00.70.7-0.7
Stereotopy head waving bouts, day 70.40.41.1-0.5-0.3-0.2-1.10.0-0.7-0.80.9
Stereotopy head waving duration, day 70.60.72.1-1.0-0.8-0.8-1.5-0.5-0.4-0.50.5
Locomotion velocity, session 82.32.74.2-2.0-1.7-1.7-1.2-2.11.61.5-1.3
Locomotion distance, session 80.40.62.0-0.8-0.5-0.4-1.4-0.3-0.7-0.60.9
Degree of sensitization distance2.52.64.4-1.9-2.1-2.1-1.6-1.70.81.1-1.1
Degree of sensitization stereotypy0.40.41.10.10.20.3-0.60.4-0.9-0.91.0
Conditioned locomotion0.91.12.70.71.31.41.60.41.1-0.0-0.6
Cocaine response after cond. corrected0.40.51.50.80.70.71.20.60.40.0-0.4
Cocaine response after cond. not corrected0.60.71.91.00.90.91.40.80.4-0.3-0.3
Cocaine response before conditioning1.31.62.51.31.31.30.91.5-0.8-1.61.0
Saline control response0.81.12.80.30.40.3-0.70.8-1.6-1.31.7
Bone: connectivity density0.30.51.0-0.7-0.7-0.6-0.1-0.60.90.7-1.0
Bone: cortical apparent density1.52.05.3-1.8-1.8-1.6-2.3-1.2-0.3-0.10.3
Bone: cortical area1.93.04.12.02.02.01.31.9-1.4-1.41.5
Bone: cortical porosity0.20.30.6-0.6-0.3-0.4-0.6-0.70.10.80.2
Bone: cortical porosity0.40.40.9-0.7-0.4-0.5-0.6-0.90.41.0-0.0
Bone: cortical thickness1.32.13.41.61.81.91.01.5-1.2-1.11.4
Bone: cortical thickness0.10.10.3-0.10.20.10.3-0.30.60.4-0.3
Bone: cortical tissue density1.62.25.5-2.0-1.9-1.7-2.3-1.4-0.20.00.1
Condit. Reinf. active minus inactive responses0.30.40.7-0.6-0.3-0.4-0.1-0.80.80.8-0.6
Condit. Reinf. active-inactive response ratio0.10.10.2-0.4-0.3-0.3-0.3-0.40.20.1-0.1
Condit. Reinf. active responses1.01.21.9-1.2-1.0-1.0-0.5-1.41.21.3-1.1
Condit. Reinf. inactive responses0.60.81.1-1.0-0.9-1.0-0.6-1.00.81.0-0.7
Incentive salience index mean0.50.61.7-0.2-0.0-0.10.7-0.61.31.1-1.2
Condit. Reinf. lever presses0.30.51.20.40.30.31.10.01.00.6-0.9
Condit. Reinf. active minus inactive responses3.44.46.62.22.52.61.62.3-1.5-2.01.7
Condit. Reinf. active-inactive response ratio3.43.96.21.72.02.20.72.1-1.9-2.52.2
Condit. Reinf. active responses3.65.07.92.52.82.81.92.5-1.5-1.81.7
Condit. Reinf. inactive responses0.81.01.71.31.31.10.81.2-0.9-0.60.7
Condit. Reinf. lever presses4.66.310.63.13.33.22.82.7-1.2-1.41.1
Condit. Reinf. lever reinforcers received4.15.79.52.83.13.12.42.6-1.2-1.81.4
Conditioned reinforcement - actives0.50.82.1-0.20.10.10.7-0.71.41.4-1.2
Conditioned reinforcement - inactives1.01.54.31.01.10.92.10.11.41.1-1.2
Conditioned locomotion1.31.72.9-1.4-1.0-1.0-0.8-1.71.41.7-1.1
Patch foraging indifference point 0 sec0.20.30.60.70.70.70.80.7-0.0-0.60.1
Patch foraging indifference point AUC0.71.12.9-0.8-1.2-1.2-1.7-0.1-1.1-0.40.8
Delay disc. indifference point, 0s delay1.31.53.80.60.10.2-0.71.3-1.9-1.71.5
Delay disc. indifference point, 16s delay0.70.81.71.31.11.11.11.0-0.4-0.40.2
Delay disc. indifference point, 2s delay0.10.10.3-0.1-0.2-0.2-0.50.0-0.5-0.10.2
Delay disc. indifference point, 24s delay0.50.62.01.20.60.41.40.70.10.3-0.5
Delay disc. indifference point, 4s delay0.10.10.30.20.20.3-0.10.4-0.5-0.50.4
Delay disc. indifference point, 8s delay0.91.02.7-1.0-1.3-1.4-1.6-0.5-0.7-0.30.4
Indifference point function ln k0.61.02.70.71.11.21.70.21.20.3-1.0
Indifference point function log k0.61.02.70.71.11.21.70.21.20.3-1.0
Patch foraging total patch changes 0 sec0.20.40.80.80.70.80.90.70.1-0.6-0.0
Patch foraging total patch changes 12 sec0.30.30.60.60.40.40.10.8-0.8-0.70.6
Patch foraging total patch changes 18 sec1.21.93.6-0.5-1.1-1.1-1.80.5-1.7-1.91.5
Patch foraging total patch changes 24 sec0.30.51.30.80.50.40.51.2-0.6-1.00.3
Patch foraging total patch changes 6 sec0.30.41.00.30.0-0.0-0.30.7-0.9-1.00.8
Patch foraging time to switch 0 sec0.71.42.6-1.3-1.5-1.6-1.2-1.30.31.1-0.4
Patch foraging water rate 0 sec0.81.74.8-0.8-0.8-0.60.6-1.12.21.2-2.1
Patch foraging water rate 12 sec0.61.24.11.10.81.02.00.51.10.0-1.2
Patch foraging water rate 18 sec1.11.74.1-0.9-0.7-0.60.3-1.31.91.5-2.0
Patch foraging water rate 24 sec0.50.72.00.60.71.01.40.41.0-0.5-0.7
Patch foraging water rate 6 sec0.71.02.90.20.20.21.3-0.31.60.9-1.7
Seeking ratio, delayed vs. immediate footshock0.70.91.11.11.11.00.70.9-1.0-0.81.0
Distance traveled before self-admin1.41.93.71.61.91.91.51.2-0.6-0.60.8
Distance traveled after self-admin1.92.44.21.92.02.11.51.7-0.8-0.80.8
Extensor digitorum longus weight0.10.40.9-0.9-0.7-0.7-0.7-0.70.60.2-0.5
Bone: elastic displacement0.00.00.1-0.1-0.1-0.20.1-0.10.30.2-0.4
Bone: elastic work1.62.14.11.91.91.72.01.5-0.2-0.50.2
Bone: endosteal estimation0.81.83.21.51.11.10.71.8-1.6-1.51.3
Bone: endosteal perimeter0.51.01.91.41.11.10.91.3-0.9-0.60.7
Epididymis fat weight0.00.10.30.10.1-0.20.4-0.10.50.5-0.5
Delta time in closed arm before/after self-admin0.60.61.60.1-0.00.00.8-0.31.01.0-1.3
Delta time in open arm before/after self-admin0.20.20.40.20.50.60.10.2-0.1-0.60.5
Diff in mean of infusions in LGA sessions0.50.61.50.0-0.3-0.5-0.80.4-1.2-0.91.1
Delay discount exponential model param0.20.20.7-0.30.00.00.3-0.40.80.6-0.5
Extinction: sum of active levers before priming2.02.23.11.61.31.30.71.7-1.6-1.81.6
Active lever presses in extinction session 60.90.82.10.70.50.6-0.41.1-1.5-1.01.2
Bone: final force1.11.73.01.71.61.61.41.4-0.8-0.60.8
Bone: final moment1.72.74.72.22.02.01.81.8-0.9-0.80.9
Food consumed during 24 hour testing period0.40.51.50.50.50.51.20.10.90.4-0.9
Glucose1.32.05.1-0.4-0.6-0.60.9-1.02.02.0-2.3
Heart weight0.60.91.81.21.11.11.41.0-0.1-0.50.2
Delay discount hyperbolic model param0.10.10.4-0.10.10.10.4-0.20.70.4-0.3
Intermittent access intake day 1-15 change0.10.30.60.80.70.50.60.4-0.50.40.4
Intermittent access intake escalation0.10.20.40.60.60.40.30.3-0.50.30.5
Intermittent access intake escalation 22.42.75.01.61.51.30.31.7-2.2-1.52.2
Intermitt. access day 1 inactive lever presses0.72.86.42.22.01.92.51.7-0.1-0.5-0.1
Intermitt. access day 15 inactive lever presses0.51.03.11.01.00.81.80.30.90.9-0.9
Intermitt. access escalation Index0.91.32.90.50.90.9-0.40.9-1.5-1.51.7
Intermittent access day 1 total infusions0.91.54.3-0.60.50.50.9-1.32.11.5-1.3
Intermittent access day 15 total infusions0.40.61.10.31.00.91.1-0.30.91.0-0.5
Intermittent access terminal intake (last 3 days)0.60.81.90.91.41.21.30.30.30.50.1
Intermittent access total infusions0.81.02.20.10.80.71.2-0.61.51.3-1.0
Intermittent access day 1 locomotion0.60.81.60.11.11.11.0-0.41.20.9-0.6
Intermittent access day 15 total locomotion0.40.71.7-0.10.30.20.7-0.61.31.3-1.0
Intermittent access total locomotion0.91.12.8-0.50.20.10.6-1.01.71.6-1.2
Intermittent access standard deviation1.63.45.61.91.71.60.52.0-2.4-1.82.3
Left kidney weight2.210.416.33.94.03.73.33.8-1.7-2.22.0
Right kidney weight2.29.916.23.94.03.73.53.6-1.4-1.91.6
Cocaine induced anxiety0.40.61.8-0.4-0.8-0.9-1.3-0.2-0.8-0.30.7
Post-drug Anxiety0.40.41.20.1-0.1-0.2-0.80.4-1.1-0.60.8
Baseline Anxiety1.01.12.91.01.41.41.70.80.4-0.0-0.2
Tail length3.011.721.64.63.94.04.54.0-1.1-1.60.8
Length with tail4.017.233.95.65.05.05.84.5-0.8-1.40.5
Length without tail0.93.06.02.52.02.02.42.0-0.5-0.70.3
Times rat made contact with spout0.40.51.3-0.8-0.7-0.7-1.1-0.5-0.4-0.20.5
Lifetime Intake0.80.92.4-0.20.60.50.9-0.91.51.3-1.0
Liver weight, left0.10.20.40.50.60.60.60.5-0.0-0.20.1
Liver weight, right0.10.10.40.20.00.10.7-0.00.50.4-0.5
Locomotor activity0.50.71.8-0.8-1.3-1.3-1.1-0.6-0.20.20.1
Locomotor testing distance0.81.42.8-1.4-1.6-1.6-1.7-1.0-0.10.2-0.0
Locomotor testing rearing1.32.57.6-1.6-1.6-1.4-2.7-0.6-1.4-0.91.5
Locomotion in novel chamber0.50.62.0-0.9-0.8-0.7-1.4-0.2-0.6-0.60.5
Locomotion in novel chamber post-restriction0.00.10.2-0.1-0.3-0.20.1-0.20.20.1-0.4
Fecal boli incidents, locomotor time 12.43.55.5-2.0-1.5-1.3-0.7-2.32.12.3-2.1
Change in fecal boli incidents, locomotor task1.61.63.8-0.00.0-0.0-1.40.7-1.9-1.81.9
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.1-0.00.0-0.10.20.2-0.3
Bouts of movement, locomotor time 10.50.61.50.50.50.5-0.20.8-1.2-0.80.9
Total resting periods, locomotor time 10.20.30.60.30.50.6-0.10.5-0.8-0.40.5
Rest time, locomotor task time 10.20.30.7-0.40.20.30.2-0.50.80.8-0.7
Distance moved, locomotor task time 10.20.30.70.5-0.0-0.30.00.6-0.6-0.80.6
Vertical activity count, locomotor time 10.61.42.31.31.00.80.51.5-1.3-1.51.3
Time >=10cm from walls, locomotor time 20.00.10.10.2-0.1-0.2-0.10.3-0.4-0.30.2
Bouts of movement, locomotor time 20.60.92.2-0.6-0.5-0.30.2-0.81.11.5-1.5
Total resting periods, locomotor time 20.50.81.9-0.6-0.6-0.30.0-0.81.11.4-1.4
Rest time, locomotor task time 20.30.30.80.50.80.90.80.30.2-0.10.0
Distance moved, locomotor task time 20.40.50.8-0.1-0.5-0.7-0.90.3-0.9-0.80.8
Vertical activity count, locomotor time 20.71.02.50.40.10.2-0.71.0-1.6-1.31.4
Light reinforcement 10.10.31.0-0.6-0.9-1.0-0.6-0.40.10.0-0.3
Light reinforcement 25.17.810.6-3.1-3.1-3.2-1.7-3.32.62.5-2.6
Bone: marrow area0.92.03.51.61.11.10.71.9-1.6-1.61.4
Bone: maximum diameter1.01.93.21.81.71.71.81.6-0.3-0.80.3
Bone: maximum force2.44.36.32.52.42.41.62.3-1.8-1.51.8
Bone: maximum moment3.25.68.32.92.72.71.92.7-1.9-1.81.8
Mean time between licks in bursts0.10.20.50.50.70.70.60.20.20.0-0.0
Mean num. licks in bursts1.32.05.11.10.70.7-0.41.4-2.2-1.42.1
Cd content in liver1.21.33.5-0.9-0.9-1.0-1.9-0.2-1.3-1.11.3
Co content in liver0.91.01.7-1.1-0.8-0.8-0.5-1.31.11.3-0.9
Cu content in liver1.41.74.91.21.31.22.20.41.21.1-1.2
Fe content in liver1.31.52.7-1.0-1.0-1.2-0.3-1.31.41.7-1.6
K content in liver0.70.72.10.90.80.81.50.40.70.5-0.6
Mg content in liver1.01.12.30.30.40.31.4-0.41.51.4-1.4
Mn content in liver0.60.71.30.91.21.20.90.8-0.1-0.40.5
Na content in liver1.82.04.31.91.71.72.11.4-0.1-0.10.1
Rb content in liver0.10.10.30.0-0.0-0.10.4-0.00.50.2-0.5
Se content in liver1.61.93.2-1.8-1.5-1.6-1.4-1.71.01.1-0.7
Sr content in liver0.40.40.7-0.5-0.5-0.4-0.2-0.80.90.7-0.7
Zn content in liver2.83.15.2-1.6-1.4-1.6-0.4-2.12.12.3-1.9
Bone: minimum diameter6.010.914.53.43.23.21.33.8-3.6-3.63.7
Time in familiar zone, hab. session 10.40.40.70.50.40.30.00.8-0.8-0.90.7
Time in novel zone, hab. session 10.10.10.2-0.4-0.3-0.2-0.1-0.40.40.4-0.3
Total zone transitions, hab. session 11.52.14.60.80.80.9-0.61.4-2.1-1.92.1
Total locomotion distance, hab. session 13.95.59.92.01.81.90.12.6-3.1-2.83.0
Locomotion velocity, hab. session 12.02.86.01.31.11.2-0.31.7-2.5-2.02.3
Time in familiar zone, hab. session 20.30.30.40.70.60.70.50.7-0.3-0.60.2
Time in novel zone, hab. session 20.40.40.9-0.8-0.9-0.9-0.6-0.70.30.5-0.4
Total zone transitions, hab. session 20.00.00.1-0.2-0.00.1-0.3-0.30.1-0.00.3
Total locomotion distance, hab. session 20.60.81.40.70.70.80.00.8-1.0-1.21.2
Locomotion velocity, hab. session 20.50.71.30.60.70.80.00.8-0.9-1.11.1
Novel to familiar place preference ratio1.61.84.01.10.80.9-0.01.4-2.0-1.41.9
Novelty place preference1.21.32.71.00.70.80.11.3-1.6-1.31.5
Time in novel zone, NPP test1.01.02.50.80.50.6-0.11.1-1.6-1.21.4
Total zone transitions, NPP test0.10.10.2-0.4-0.3-0.2-0.4-0.40.20.2-0.2
Total locomotion distance, NPP test1.92.64.21.51.31.40.31.8-2.0-1.91.9
Locomotion velocity, NPP test2.23.14.61.71.61.70.52.0-2.1-2.02.0
Intraocular pressure0.40.61.5-0.3-0.2-0.10.4-0.71.01.2-1.1
Delta distance traveled before/after self-admin0.10.10.2-0.1-0.3-0.3-0.20.10.00.4-0.4
Delta ambulatory time before/after self-admin0.10.10.30.30.20.20.00.5-0.4-0.20.2
Parametrial fat weight0.20.40.8-0.6-0.5-0.50.0-0.80.90.8-0.8
Pavlov. Cond. lever latency0.30.30.7-0.7-0.8-0.8-0.8-0.5-0.10.2-0.1
Pavlov. Cond. magazine entry latency0.20.20.4-0.5-0.2-0.2-0.2-0.60.60.6-0.5
Pavlov. Cond. change in total contacts0.00.00.10.00.20.20.30.10.3-0.0-0.3
Pavlov. Cond. index score0.10.10.20.10.40.40.30.10.40.1-0.2
Pavlov. Cond. latency score0.10.10.20.30.50.50.40.20.30.0-0.1
Pavlov. Cond. lever contacts0.60.71.51.01.21.11.20.80.2-0.1-0.0
Pavlov. Cond. magazine entry number0.00.00.00.2-0.1-0.10.20.2-0.2-0.10.1
Pavlov. Cond. intertrial magazine entries0.10.20.4-0.4-0.3-0.3-0.7-0.2-0.4-0.30.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.20.50.50.50.10.50.1-0.3
Pavlov. Cond. response bias0.10.10.30.20.50.50.40.10.40.2-0.3
Pavlov. Cond. lever latency2.63.55.8-2.3-2.4-2.4-2.0-2.10.91.3-0.9
Pavlov. Cond. magazine entry latency1.72.05.41.61.81.72.30.90.70.5-0.8
Pavlov. Cond. change in total contacts3.86.09.23.03.03.02.22.8-1.7-1.81.6
Pavlov. Cond. index score2.23.05.52.22.32.32.21.8-0.4-0.50.3
Pavlov. Cond. latency score2.02.64.92.12.22.12.21.6-0.2-0.40.1
Pavlov. Cond. lever contacts2.83.96.32.42.52.42.02.2-1.1-1.41.0
Pavlov. Cond. magazine entry number1.01.22.8-1.3-1.4-1.3-1.7-1.0-0.2-0.00.5
Pavlov. Cond. intertrial magazine entries1.21.82.4-1.2-1.4-1.4-0.3-1.51.51.5-1.5
Pavlov. Cond. lever-magazine prob. diff.2.43.25.72.32.42.32.31.8-0.4-0.50.3
Pavlov. Cond. response bias3.34.57.82.62.82.72.32.3-1.0-1.31.0
Time in closed arm before self-admin0.10.10.3-0.3-0.2-0.2-0.5-0.3-0.2-0.40.5
Time in closed arm after self-admin0.30.40.9-0.10.00.10.5-0.60.90.8-0.9
Time in open arm before self-admin0.60.71.81.10.90.81.40.80.20.2-0.4
Time in open arm after self-admin1.41.52.01.41.41.40.81.4-1.0-1.21.2
Bone: periosteal estimation1.94.06.22.32.02.01.22.5-2.0-2.01.9
Bone: periosteal perimeter1.62.84.11.91.71.71.02.0-1.7-1.71.5
Bone: post-yield work1.21.82.81.21.21.20.21.6-1.7-1.61.5
Progressive ratio test 1 active lever presses1.11.42.70.41.61.61.7-0.21.40.7-0.6
Progressive ratio test 1 breakpoint1.21.43.10.61.71.71.8-0.11.30.6-0.5
Progressive ratio test 1 inactive lever presses0.81.23.00.91.41.41.70.20.90.6-0.6
Progressive ratio test 2 active lever presses1.21.43.7-0.40.30.41.0-1.01.91.6-1.5
Progressive ratio test 2 breakpoint1.11.23.4-0.40.30.30.9-1.01.81.5-1.4
Progressive ratio test 2 inactive lever presses1.01.53.60.81.21.11.9-0.11.31.5-1.2
Incentive Sensitization - Responses0.71.01.7-0.8-0.8-1.0-0.0-1.01.21.2-1.3
Incentive Sensitization - Breakpoint0.70.91.4-0.8-0.9-1.0-0.2-1.01.11.1-1.2
Sum of active levers in priming session hrs 5-62.01.94.4-0.1-0.3-0.3-1.60.7-2.0-1.82.1
Progressive ratio0.50.72.0-0.6-1.2-1.2-1.4-0.2-0.6-0.40.2
Food seeking constrained by brief footshock2.32.83.91.81.71.80.72.0-1.8-1.81.6
Seeking ratio, punishment vs. effort0.91.33.11.11.61.71.80.70.4-0.0-0.1
Retroperitoneal fat weight0.41.92.4-1.4-1.4-1.5-0.5-1.51.41.5-1.4
Reaction time number correct0.10.10.80.10.20.30.30.40.2-0.90.0
Reaction time mean minus median0.10.20.70.50.40.50.80.20.50.4-0.5
Reaction time mean minus median AUC0.30.61.80.60.60.71.30.31.00.4-1.0
Reaction time num false alarms0.40.61.4-1.2-0.7-0.8-1.1-0.80.30.2-0.1
Reaction time num false alarms AUC0.60.92.0-1.4-0.9-1.1-1.4-1.00.40.2-0.1
Reaction time trials correct on left0.10.10.80.10.20.30.30.40.2-0.90.0
Reaction time trials on left0.10.10.70.10.20.30.30.30.2-0.8-0.0
Reaction time mean0.40.61.5-0.3-0.2-0.10.5-0.81.21.2-1.1
Reaction time mean AUC0.81.33.0-0.5-0.3-0.20.6-1.11.71.7-1.6
Median of all reaction times0.60.81.9-0.6-0.5-0.40.1-1.11.21.4-1.2
Reaction time omissions0.30.51.3-0.6-0.4-0.4-0.2-0.90.71.1-0.5
Reaction time false alarm rate0.60.81.5-1.2-0.9-1.0-1.1-1.10.50.7-0.4
Reaction time premature initiation rate0.00.10.2-0.10.10.0-0.4-0.1-0.40.00.4
Reaction time premature initiations0.00.10.2-0.00.20.2-0.20.1-0.2-0.40.4
Std. dev. reaction times0.30.61.40.30.40.41.0-0.31.01.2-0.9
Reaction time trials completed0.10.10.70.10.20.30.30.30.2-0.8-0.0
Reaction time trials AUC0.10.10.6-0.00.10.20.20.20.3-0.8-0.1
Run reversals in cocaine runway, females1.21.23.1-0.2-0.2-0.20.8-0.81.61.7-1.7
Run reversals in cocaine runway, males0.80.81.7-1.3-1.1-1.0-1.0-1.10.40.3-0.2
Latency to leave start box in cocaine runway0.10.10.3-0.1-0.5-0.60.00.20.2-0.1-0.4
Latency to leave start box in cocaine runway, F0.30.30.8-0.6-0.9-0.9-0.5-0.00.1-0.4-0.2
Latency to leave start box in cocaine runway, M0.10.10.20.40.20.10.40.20.20.2-0.4
Std. dev. time between licks in bursts0.60.91.30.80.90.90.11.0-1.1-1.01.1
Total sessions with >9 infusions0.20.30.8-0.90.20.3-0.7-0.70.2-0.40.6
Short access day 1 total inactive lever presses0.40.61.61.00.80.81.30.60.30.1-0.4
Short access day 10 total inactive lever presses0.71.73.82.01.41.41.91.4-0.2-0.3-0.2
Short access day 1 total infusions0.50.71.70.61.21.31.00.50.2-0.50.2
Short access day 10 total infusions0.20.20.6-0.30.30.40.3-0.70.80.6-0.2
Short access total infusions0.20.30.8-0.40.50.50.2-0.70.90.6-0.3
Short access day 1 locomotion0.50.61.3-1.1-0.9-0.7-1.1-0.80.40.2-0.1
Short access day 10 total locomotion0.81.42.61.11.51.60.61.2-1.0-1.01.3
Short access total locomotion0.20.30.8-0.10.70.8-0.30.1-0.3-0.40.9
One hour access (0.3 mA shock)0.40.51.10.81.11.00.80.4-0.00.10.2
Compulsive drug intake3.94.68.51.81.41.4-0.02.4-2.9-2.92.7
One hour access (shock baseline)0.60.92.5-0.20.30.20.8-1.01.41.6-1.1
Social response proportion2.73.05.12.12.22.32.01.8-0.7-1.01.1
Social responses0.30.40.80.30.10.20.9-0.10.80.8-0.8
Social time0.50.71.40.60.40.7-0.11.0-1.2-1.20.9
Soleus weight0.61.96.0-1.5-1.3-1.4-2.4-0.9-1.1-0.31.0
Bone: stiffness1.52.43.31.71.71.70.61.6-1.8-1.21.8
Tibialis anterior weight0.41.33.1-0.10.10.2-1.30.7-1.6-1.81.7
Time to tail flick, vehicle, before self-admin0.50.61.30.20.20.20.9-0.31.21.1-0.9
Time to tail flick, vehicle, after self-admin0.81.02.20.60.70.71.5-0.21.11.3-1.2
Time to tail flick, test, before self-admin0.20.20.5-0.4-0.7-0.7-0.3-0.20.30.4-0.5
Time to tail flick, test, after self-admin0.20.20.6-0.2-0.00.00.1-0.20.60.8-0.6
Delta time to tail flick, vehicle, before/after SA0.20.20.50.50.60.70.70.30.1-0.1-0.2
Delta time to tail flick, test, before/after SA0.10.10.50.10.40.30.4-0.30.40.7-0.2
Tibia length1.23.37.22.42.22.12.71.9-0.1-0.60.1
Ambulatory time before self-admin1.01.42.51.41.61.61.11.1-0.8-0.80.9
Ambulatory time after self-admin1.82.13.51.81.91.81.51.7-0.9-0.80.8
Bone: tissue strength3.73.85.42.32.22.31.72.3-1.4-1.71.4
Total heroin consumption3.44.08.91.01.21.3-0.71.7-2.8-2.73.0
Bone: trabecular number0.10.20.60.40.30.40.70.40.3-0.2-0.4
Bone: trabecular spacing1.52.02.91.51.71.50.61.4-1.6-0.91.7
Bone: trabecular thickness0.60.72.1-0.4-0.4-0.40.6-0.61.40.8-1.4
Bone: trabecular tissue density1.62.34.3-1.9-2.1-2.0-1.9-1.50.40.6-0.5
Water consumed over 24 hours0.50.71.70.91.11.11.30.60.4-0.1-0.1
Number of responses in last shaping day0.20.30.50.60.60.60.70.40.0-0.60.2