Camsap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	intron excision ratio	chr12_6453968_6455440	0.06	0.04	5.6e-03	0.05	0.03	0.02	0.03	3.3e-05	4.2e-03	8.8e-03	9.1e-04
2	PL	intron excision ratio	chr12_6455175_6455440	0.08	0.04	1.5e-04	0.03	0.04	0.03	0.04	4.4e-04	7.0e-05	2.4e-04	3.6e-05
3	NAcc	gene expression	Camsap3	0.05	0.03	1.8e-04	0.03	0.03	0.03	0.03	9.0e-05	3.2e-05	1.8e-05	5.6e-05
4	PL	intron excision ratio	chr12_6453968_6455440	0.04	0.03	1.5e-03	0	0.02	0.02	0.01	2.6e-01	4.3e-03	5.6e-03	3.3e-02
5	Brain	gene expression	Camsap3	0.06	0.04	4.6e-04	0.03	0.02	0.02	0.02	1.2e-03	5.1e-03	2.7e-03	1.1e-02
6	Liver	gene expression	Camsap3	0.12	0.06	1.1e-05	-0	0.02	0.01	0	6.9e-01	6.4e-03	9.7e-03	2.9e-01
7	PL	intron excision ratio	chr12_6453968_6455128	0.03	0.02	8.3e-04	0.03	0.02	0.02	0.02	6.1e-04	1.0e-03	2.8e-03	2.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	2.3	3.9	7.9	-2.8	1.9	1.2	-2.1	1.3	-2.8	-0.6
Area under the delay curve	1.8	2.1	5.9	1.1	-1.4	0.2	2.1	0.6	2.4	-0.8
BMI with tail	0.9	3.2	10.0	-3.2	1.5	1.6	-1.0	2.3	-0.9	-0.6
BMI without tail	2.6	7.8	18.2	-4.3	3.1	3.4	-1.4	3.6	-0.5	-0.2
Body weight	8.3	36.5	83.6	-9.1	6.6	7.2	-4.0	7.5	-2.1	0.3
Weight adjusted by age	0.6	0.8	2.0	-1.4	0.7	0.5	-1.2	0.1	-1.1	-0.5
Bone surface	2.5	4.6	11.1	-3.3	2.3	1.9	-1.8	2.4	-1.8	-0.5
Bone volume	1.4	2.5	6.1	-2.5	1.3	0.7	-1.3	1.4	-2.0	-1.1
Breakpoint value in progressive ratio session	0.5	0.6	1.4	0.0	-0.1	0.3	1.0	1.2	0.9	-1.0
Number of licking bursts	2.1	3.5	10.3	-0.9	2.2	1.4	-2.4	-0.1	-1.0	3.2
Context. condit. distance diff. score	2.3	2.7	6.9	-1.9	1.4	1.8	-0.0	2.6	-0.2	-1.8
Locomotion velocity, session 1	0.5	0.6	1.1	1.1	-0.7	-0.5	1.0	0.2	1.0	-0.5
Locomotion distance, session 1	0.9	1.1	3.1	1.8	-1.1	-1.1	1.0	-0.8	0.7	-0.3
Locomotion velocity, session 2	0.2	0.3	0.8	0.7	-0.1	0.2	0.4	-0.0	0.9	0.5
Locomotion distance, session 2	0.7	1.0	4.1	2.0	-0.7	-0.7	0.5	-1.2	0.3	0.2
Locomotion velocity, session 3	0.2	0.2	0.9	-0.3	0.1	0.3	0.4	0.7	0.1	-0.9
Locomotion distance, session 3	0.3	0.3	0.8	0.4	0.1	-0.4	-0.4	-0.8	-0.9	0.0
Stereotopy head waving bouts, day 3	2.0	2.3	4.4	-2.1	2.0	1.5	-1.7	0.9	-1.5	0.5
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.2	0.2	-0.1	-0.3	-0.2	-0.3	0.3
Locomotion velocity, session 7	1.3	1.4	4.8	0.7	-0.9	-0.0	1.7	0.8	2.2	-0.3
Locomotion distance, session 7	0.4	0.6	1.4	0.8	-0.4	0.2	1.1	0.4	1.2	-0.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.7	-0.4	-0.4	0.4	-0.3	0.3	-0.3
Stereotopy head waving duration, day 7	0.4	0.5	1.1	1.0	-0.7	-0.8	0.6	-0.5	0.6	-0.2
Locomotion velocity, session 8	0.3	0.4	1.0	-0.3	0.3	0.7	0.3	1.0	0.9	0.2
Locomotion distance, session 8	0.7	1.1	3.2	-1.0	1.0	1.2	0.0	1.8	0.3	-0.7
Degree of sensitization distance	0.9	0.9	2.7	1.2	-0.8	-0.1	1.2	0.0	1.6	0.0
Degree of sensitization stereotypy	0.5	0.5	0.9	0.9	-0.8	-0.7	0.9	-0.1	0.7	-0.7
Conditioned locomotion	0.3	0.3	1.2	-0.2	-0.2	-0.6	-0.3	-0.7	-1.1	-0.4
Cocaine response after cond. corrected	0.2	0.2	0.8	-0.9	-0.3	-0.5	-0.1	0.1	0.3	0.6
Cocaine response after cond. not corrected	0.3	0.4	0.6	-0.8	-0.7	-0.5	0.6	0.6	0.6	-0.5
Cocaine response before conditioning	1.1	1.3	6.0	0.2	-0.6	0.2	1.3	0.9	0.5	-2.5
Saline control response	2.7	3.6	7.1	-1.7	2.7	2.5	-2.1	1.0	-1.8	0.8
Bone: connectivity density	3.8	6.0	11.6	-3.4	2.8	2.3	-2.3	2.3	-2.4	-0.4
Bone: cortical apparent density	0.4	0.5	1.8	0.4	-0.7	-0.3	1.0	0.2	1.4	-0.0
Bone: cortical area	1.5	2.3	6.1	-1.9	1.2	1.9	0.2	2.5	0.7	-0.8
Bone: cortical porosity	0.1	0.2	0.4	-0.2	0.4	0.1	-0.6	-0.3	-0.6	0.3
Bone: cortical porosity	0.1	0.1	0.2	0.5	-0.3	-0.3	0.1	-0.4	-0.2	-0.3
Bone: cortical thickness	1.2	1.9	4.5	-1.9	1.3	1.9	-0.2	2.1	0.4	-0.3
Bone: cortical thickness	0.9	1.0	2.4	-1.2	1.2	1.6	-0.4	1.3	-0.1	-0.2
Bone: cortical tissue density	0.4	0.5	1.6	0.5	-0.8	-0.4	0.9	0.0	1.3	0.0
Condit. Reinf. active minus inactive responses	0.9	1.0	1.7	0.8	-1.2	-0.9	1.3	-0.0	1.1	-0.9
Condit. Reinf. active-inactive response ratio	0.7	0.8	1.7	0.4	-0.9	-0.6	1.3	0.5	1.2	-1.0
Condit. Reinf. active responses	0.7	0.9	1.5	1.0	-1.1	-0.8	1.2	-0.1	0.7	-1.2
Condit. Reinf. inactive responses	0.6	0.7	1.9	1.4	-0.8	-0.6	0.8	-0.7	0.2	-0.9
Incentive salience index mean	0.9	1.1	2.0	1.1	-1.2	-1.0	1.3	-0.3	0.6	-1.4
Condit. Reinf. lever presses	0.7	1.0	2.9	1.0	-1.0	-0.9	1.1	-0.4	0.2	-1.7
Condit. Reinf. active minus inactive responses	1.3	1.7	4.2	-0.9	1.2	2.0	0.2	2.0	1.1	0.0
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.3	-0.3	0.6	1.5	0.4	1.5	1.4	0.5
Condit. Reinf. active responses	1.3	1.8	5.0	-1.0	1.0	1.9	0.5	2.2	0.9	-0.9
Condit. Reinf. inactive responses	0.4	0.5	2.1	-0.6	0.4	0.6	0.2	0.9	-0.4	-1.4
Condit. Reinf. lever presses	0.4	0.5	1.8	-0.1	-0.0	0.2	0.8	1.0	0.4	-1.4
Condit. Reinf. lever reinforcers received	1.0	1.4	3.8	-0.6	0.8	1.7	0.7	2.0	1.1	-0.9
Conditioned reinforcement - actives	1.7	3.0	5.7	-2.0	2.4	2.3	-1.5	1.7	-0.8	0.3
Conditioned reinforcement - inactives	0.7	1.0	2.0	-0.9	1.0	0.7	-1.4	-0.5	-1.2	1.1
Conditioned locomotion	1.4	1.8	2.8	-1.7	1.5	1.7	-0.6	1.4	-0.7	-1.4
Patch foraging indifference point 0 sec	0.7	1.3	5.3	-0.2	0.1	-0.8	-1.4	-1.2	-2.3	0.2
Patch foraging indifference point AUC	1.0	1.5	2.7	-1.5	1.6	1.2	-1.5	0.7	-1.1	0.6
Delay disc. indifference point, 0s delay	2.0	2.1	6.8	-0.9	-0.2	1.3	1.4	1.9	2.6	0.0
Delay disc. indifference point, 16s delay	0.4	0.5	1.5	0.6	-0.6	0.0	1.0	0.3	1.2	-0.2
Delay disc. indifference point, 2s delay	4.2	4.7	10.4	1.7	-2.4	-0.7	3.2	0.6	3.0	-2.1
Delay disc. indifference point, 24s delay	0.6	0.7	1.5	1.1	-0.8	-0.4	0.9	-0.3	1.2	0.3
Delay disc. indifference point, 4s delay	2.2	2.3	5.0	0.9	-1.8	-0.3	2.2	0.5	2.0	-1.6
Delay disc. indifference point, 8s delay	0.6	0.7	1.4	0.8	-0.8	0.4	1.2	0.1	1.1	-0.7
Indifference point function ln k	0.1	0.1	0.4	0.6	0.2	0.1	-0.3	-0.4	-0.5	0.2
Indifference point function log k	0.1	0.1	0.4	0.6	0.2	0.1	-0.3	-0.4	-0.5	0.2
Patch foraging total patch changes 0 sec	1.0	1.9	7.2	-0.0	0.2	-0.9	-1.6	-1.5	-2.7	0.3
Patch foraging total patch changes 12 sec	0.7	0.9	3.0	-1.2	0.5	-0.3	-1.2	-0.2	-1.7	0.0
Patch foraging total patch changes 18 sec	1.1	1.7	5.7	-0.6	0.8	-0.4	-1.9	-0.9	-2.4	0.8
Patch foraging total patch changes 24 sec	0.8	1.3	5.8	0.2	0.2	-0.6	-1.2	-1.2	-2.4	-0.5
Patch foraging total patch changes 6 sec	0.9	1.4	5.8	-0.7	0.5	-0.5	-1.6	-0.7	-2.4	-0.0
Patch foraging time to switch 0 sec	1.4	2.9	7.1	0.5	-2.3	-1.6	2.1	0.0	2.7	-0.1
Patch foraging water rate 0 sec	2.1	4.5	12.0	-1.0	2.7	1.7	-2.8	-0.0	-3.5	0.4
Patch foraging water rate 12 sec	0.3	0.5	1.7	0.3	0.8	0.8	-0.7	-0.3	-1.3	-0.3
Patch foraging water rate 18 sec	0.2	0.4	1.2	1.1	-0.1	0.4	0.6	-0.2	0.0	-0.9
Patch foraging water rate 24 sec	1.5	2.1	4.1	-0.9	2.0	1.9	-1.6	0.6	-1.8	0.2
Patch foraging water rate 6 sec	0.5	0.8	2.8	0.1	0.7	0.3	-0.6	-0.0	-1.7	-1.3
Seeking ratio, delayed vs. immediate footshock	1.5	1.9	4.5	1.4	-0.8	-1.7	-0.5	-2.1	-0.6	1.5
Distance traveled before self-admin	0.8	1.1	2.1	1.4	-1.1	-0.8	1.4	-0.2	1.1	-0.4
Distance traveled after self-admin	0.2	0.2	0.6	0.8	-0.2	-0.2	0.5	-0.1	0.2	-0.6
Extensor digitorum longus weight	3.1	12.3	24.8	-5.0	4.0	4.4	-1.9	4.2	-1.6	-1.3
Bone: elastic displacement	0.2	0.3	0.5	-0.5	0.7	0.5	-0.7	0.4	-0.6	0.2
Bone: elastic work	2.5	3.3	5.5	-2.4	2.3	2.0	-1.7	1.7	-1.5	0.2
Bone: endosteal estimation	0.9	2.0	3.6	-1.3	1.7	1.2	-1.9	0.2	-1.9	0.9
Bone: endosteal perimeter	0.4	0.9	1.2	-1.0	1.1	1.1	-0.5	1.0	-0.9	-0.9
Epididymis fat weight	0.1	0.4	2.1	0.2	-0.4	-0.3	0.6	0.3	-0.1	-1.5
Delta time in closed arm before/after self-admin	0.4	0.4	1.3	0.2	0.4	1.1	0.3	0.8	0.7	0.2
Delta time in open arm before/after self-admin	2.5	2.5	5.5	1.2	-2.0	-2.4	1.4	-1.3	0.6	-1.4
Diff in mean of infusions in LGA sessions	0.1	0.2	0.4	-0.4	0.4	0.3	-0.0	0.6	-0.2	-0.6
Delay discount exponential model param	2.4	2.6	6.2	-1.5	1.7	0.0	-2.4	-0.4	-2.5	1.1
Extinction: sum of active levers before priming	0.6	0.6	1.3	0.2	-1.0	-0.6	1.1	0.3	0.8	-1.0
Active lever presses in extinction session 6	0.2	0.2	0.5	-0.5	0.3	-0.3	-0.2	0.2	-0.5	-0.7
Bone: final force	2.4	3.8	7.2	-2.4	2.4	2.7	-1.3	2.2	-0.1	1.1
Bone: final moment	2.0	3.2	5.9	-2.1	2.2	2.4	-1.3	1.9	-0.2	1.2
Food consumed during 24 hour testing period	0.5	0.7	1.6	-0.5	0.9	0.1	-1.3	-0.4	-1.1	1.0
Glucose	1.2	1.9	3.2	1.6	-1.6	-1.2	1.7	-0.4	1.8	-0.5
Heart weight	0.2	0.3	1.2	0.2	0.8	1.1	-0.1	0.5	-0.0	-0.2
Delay discount hyperbolic model param	2.3	2.5	6.0	-1.4	1.7	-0.0	-2.4	-0.5	-2.4	1.1
Intermittent access intake day 1-15 change	1.0	2.1	4.3	-1.5	1.7	1.1	-2.1	0.2	-1.5	1.3
Intermittent access intake escalation	1.0	2.1	4.3	-1.5	1.7	1.1	-2.1	0.1	-1.4	1.4
Intermittent access intake escalation 2	0.5	0.6	1.3	-0.4	0.6	0.2	-1.1	-0.4	-0.8	1.1
Intermitt. access day 1 inactive lever presses	0.3	1.1	2.3	-0.7	0.9	0.5	-1.4	-0.6	-1.1	1.5
Intermitt. access day 15 inactive lever presses	0.2	0.3	1.0	-0.6	-0.6	-1.0	-0.3	-0.4	-0.3	0.2
Intermitt. access escalation Index	0.4	0.6	1.9	1.4	-0.5	-0.4	0.8	-0.2	0.3	-1.1
Intermittent access day 1 total infusions	0.5	0.8	1.8	1.3	-0.6	-0.6	1.2	-0.5	0.9	-0.9
Intermittent access day 15 total infusions	0.0	0.1	0.2	0.1	0.5	0.3	-0.2	-0.2	-0.1	-0.1
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	0.3	0.1	0.1	0.0	-0.1	0.2	0.1
Intermittent access total infusions	0.3	0.4	0.9	0.4	-0.4	-0.2	1.0	0.2	1.0	-0.7
Intermittent access day 1 locomotion	1.5	1.9	4.5	1.3	-1.4	-1.1	1.8	-0.4	1.0	-2.1
Intermittent access day 15 total locomotion	0.2	0.4	1.6	0.7	0.3	0.4	0.2	-0.1	-0.5	-1.2
Intermittent access total locomotion	0.9	1.0	3.8	0.9	-0.8	-0.5	1.3	-0.2	0.5	-1.9
Intermittent access standard deviation	0.5	0.9	2.3	-1.1	0.4	-0.0	-1.4	-0.5	-1.0	1.5
Left kidney weight	5.9	27.5	53.7	-7.3	6.3	6.1	-4.7	5.2	-3.3	1.1
Right kidney weight	5.1	23.2	47.5	-6.9	5.7	5.5	-4.2	5.0	-2.8	1.3
Cocaine induced anxiety	0.6	0.9	2.0	0.4	-0.7	-0.3	1.3	0.7	1.1	-1.4
Post-drug Anxiety	4.7	5.0	10.3	1.3	-2.8	-1.6	3.1	0.7	3.2	-1.5
Baseline Anxiety	2.0	2.3	5.6	1.1	-2.0	-1.4	1.6	-0.2	2.4	0.8
Tail length	6.1	23.7	45.2	-6.7	5.9	6.4	-3.3	5.7	-1.3	0.8
Length with tail	11.2	48.6	91.9	-9.6	8.3	8.9	-5.2	8.0	-2.5	1.4
Length without tail	7.0	22.5	46.2	-6.8	5.5	5.3	-4.4	4.8	-2.9	1.5
Times rat made contact with spout	0.7	0.8	1.6	-1.0	1.1	1.2	-0.4	1.3	0.2	0.2
Lifetime Intake	0.4	0.5	1.2	0.5	-0.7	-0.6	1.1	-0.0	1.0	-0.7
Liver weight, left	4.8	7.9	14.5	-2.9	3.4	2.1	-3.8	0.4	-3.3	2.3
Liver weight, right	1.6	2.8	5.9	-2.4	2.0	1.6	-1.6	1.6	-1.5	0.1
Locomotor activity	1.3	2.1	6.1	-1.0	2.1	2.5	-0.7	1.5	-0.4	-0.3
Locomotor testing distance	0.6	1.1	2.3	-0.7	1.5	1.1	-1.3	0.4	-1.4	0.3
Locomotor testing rearing	0.2	0.5	2.0	0.2	-0.1	-0.6	-0.7	-0.8	-1.4	-0.2
Locomotion in novel chamber	0.9	1.2	3.4	-0.2	1.8	1.4	-1.2	0.1	-1.2	0.3
Locomotion in novel chamber post-restriction	0.8	1.3	3.7	-0.6	1.7	1.9	-0.8	1.1	-0.7	-0.1
Fecal boli incidents, locomotor time 1	1.3	1.9	4.1	-1.9	1.7	2.0	-0.7	1.5	-0.5	-0.1
Change in fecal boli incidents, locomotor task	0.2	0.2	1.3	0.0	-0.3	-0.3	-0.1	-0.1	0.4	1.1
Time >=10cm from walls, locomotor time 1	1.9	2.0	4.9	0.8	-1.6	-0.9	2.2	0.4	1.8	-1.5
Bouts of movement, locomotor time 1	0.9	1.0	1.9	-1.1	1.4	1.2	-0.9	0.9	-0.7	-0.4
Total resting periods, locomotor time 1	0.8	0.9	1.7	-1.2	1.3	1.2	-0.8	1.0	-0.5	-0.4
Rest time, locomotor task time 1	1.0	1.3	3.5	-1.9	1.3	1.1	-0.6	1.4	-0.3	-0.2
Distance moved, locomotor task time 1	0.4	0.5	1.7	1.3	-0.8	-0.2	0.8	-0.5	0.8	-0.1
Vertical activity count, locomotor time 1	0.1	0.2	0.9	0.4	0.2	1.0	-0.0	0.0	0.1	-0.1
Time >=10cm from walls, locomotor time 2	0.9	1.3	3.4	-1.2	-0.3	0.5	1.2	1.8	1.2	-1.2
Bouts of movement, locomotor time 2	0.4	0.7	1.2	-0.9	0.7	0.9	-0.5	0.7	-0.8	-1.1
Total resting periods, locomotor time 2	0.4	0.6	1.0	-1.0	0.7	0.8	-0.6	0.6	-0.9	-0.9
Rest time, locomotor task time 2	0.3	0.3	0.7	0.6	-0.5	-0.8	0.6	-0.1	0.1	-0.8
Distance moved, locomotor task time 2	0.6	0.7	2.7	-0.4	0.7	0.8	-1.0	-0.3	-0.2	1.6
Vertical activity count, locomotor time 2	2.2	3.0	5.1	-1.7	2.2	2.3	-2.0	0.5	-1.1	1.7
Light reinforcement 1	0.9	2.2	4.6	1.2	-1.6	-0.7	2.1	0.4	2.1	-1.3
Light reinforcement 2	0.1	0.2	0.6	0.3	-0.2	-0.4	-0.2	-0.8	-0.1	0.8
Bone: marrow area	0.9	2.0	3.6	-1.2	1.7	1.1	-1.9	0.2	-1.9	0.9
Bone: maximum diameter	0.8	1.5	3.5	-1.9	1.3	1.4	-0.7	1.6	-0.6	-0.3
Bone: maximum force	1.6	2.9	5.3	-2.1	2.2	2.3	-1.2	1.8	-0.6	0.5
Bone: maximum moment	1.4	2.4	4.4	-1.9	2.1	2.1	-1.3	1.5	-0.7	0.6
Mean time between licks in bursts	0.7	1.8	3.3	1.8	-1.4	-1.7	0.7	-1.8	-0.0	-0.4
Mean num. licks in bursts	0.8	1.2	4.7	0.1	-1.0	-0.5	1.3	0.5	0.5	-2.2
Cd content in liver	0.2	0.2	0.8	0.9	0.2	0.5	0.4	-0.2	0.4	-0.2
Co content in liver	2.3	2.6	5.6	-0.5	1.2	0.4	-2.4	-1.4	-2.3	2.0
Cu content in liver	0.1	0.1	0.4	0.6	-0.1	-0.6	-0.0	-0.2	-0.4	-0.3
Fe content in liver	1.1	1.3	7.2	-0.2	-0.1	0.2	0.9	1.2	-0.2	-2.7
K content in liver	0.3	0.3	0.5	-0.3	-0.6	-0.2	0.6	0.7	0.4	-0.7
Mg content in liver	0.4	0.4	0.8	-0.9	0.4	0.5	-0.6	0.8	-0.2	0.6
Mn content in liver	0.3	0.3	1.3	0.2	0.0	-0.3	-0.5	-0.6	-0.1	1.2
Na content in liver	0.6	0.6	1.7	-1.2	0.7	0.8	-0.3	1.3	0.1	0.0
Rb content in liver	3.2	3.7	6.1	2.3	-2.5	-2.3	2.0	-1.3	0.9	-1.6
Se content in liver	2.7	3.2	8.5	-1.2	-0.9	0.1	1.8	2.5	1.4	-2.9
Sr content in liver	1.4	1.2	2.7	-0.6	1.0	0.6	-1.6	-0.4	-1.1	1.7
Zn content in liver	3.3	3.6	6.3	-2.1	2.3	1.5	-2.5	1.0	-2.3	0.9
Bone: minimum diameter	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	-0.2	0.0	0.4
Time in familiar zone, hab. session 1	0.6	0.6	1.6	0.2	-0.3	-1.0	-0.6	-1.3	-0.8	0.7
Time in novel zone, hab. session 1	0.5	0.5	1.5	-0.6	0.5	1.0	0.2	1.2	0.6	-0.2
Total zone transitions, hab. session 1	1.1	1.5	3.8	1.9	-1.2	-0.9	1.4	-0.7	1.2	-0.7
Total locomotion distance, hab. session 1	1.0	1.4	2.5	1.1	-1.3	-0.9	1.6	-0.0	1.2	-1.4
Locomotion velocity, hab. session 1	1.7	2.3	4.1	1.8	-1.7	-1.2	2.0	-0.4	1.5	-1.6
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.2	-0.5	-0.3	0.2	-0.1	0.3	0.2
Time in novel zone, hab. session 2	0.2	0.2	0.7	0.8	-0.2	-0.2	0.4	-0.1	0.2	-0.5
Total zone transitions, hab. session 2	0.3	0.4	1.0	-0.1	0.7	0.9	-0.5	0.1	0.2	1.0
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.7	-0.3	-0.0	0.4	-0.4	0.5	0.1
Locomotion velocity, hab. session 2	0.1	0.2	0.5	0.7	-0.1	0.0	0.3	-0.4	0.4	0.3
Novel to familiar place preference ratio	0.1	0.1	0.2	0.2	0.3	0.3	-0.0	0.1	0.4	0.5
Novelty place preference	0.1	0.1	0.3	0.6	-0.1	0.0	0.2	-0.2	0.6	0.3
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	0.1	0.2	0.1	0.0	0.5	0.3
Total zone transitions, NPP test	0.1	0.1	0.2	0.2	0.2	0.4	0.2	0.4	0.3	-0.0
Total locomotion distance, NPP test	0.8	1.1	2.6	0.6	-0.8	-0.1	1.5	0.8	1.2	-1.6
Locomotion velocity, NPP test	0.6	0.8	2.2	0.6	-0.5	0.1	1.3	0.7	0.9	-1.5
Intraocular pressure	0.9	1.4	2.3	-1.3	1.4	0.8	-0.9	0.8	-1.5	-1.2
Delta distance traveled before/after self-admin	0.7	0.7	1.7	-0.4	1.1	0.7	-1.3	-0.2	-1.1	0.7
Delta ambulatory time before/after self-admin	0.3	0.3	0.7	0.3	0.2	-0.2	-0.7	-0.9	-0.7	0.6
Parametrial fat weight	0.1	0.3	0.9	-0.9	-0.4	-0.2	0.3	0.7	0.4	-0.2
Pavlov. Cond. lever latency	2.3	2.9	4.7	-2.2	1.9	1.8	-1.9	1.3	-1.2	1.4
Pavlov. Cond. magazine entry latency	0.2	0.3	0.8	-0.5	0.6	0.9	0.1	0.6	0.3	-0.4
Pavlov. Cond. change in total contacts	1.1	1.2	3.2	0.6	-1.0	-0.4	1.6	0.4	1.8	-1.0
Pavlov. Cond. index score	0.4	0.5	1.2	0.5	-0.6	-0.3	1.1	0.1	0.8	-1.1
Pavlov. Cond. latency score	0.7	0.9	1.9	0.8	-0.8	-0.5	1.4	-0.0	1.1	-1.2
Pavlov. Cond. lever contacts	2.0	2.3	3.4	1.8	-1.7	-1.5	1.8	-0.9	1.3	-1.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.1	0.2	-0.4	-0.7	-0.5	-0.7	-0.4	1.0
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.7	1.3	-0.9	-1.1	0.3	-1.1	-0.1	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	0.4	-0.6	-0.3	1.0	0.1	0.8	-1.1
Pavlov. Cond. response bias	0.3	0.3	1.3	0.1	-0.0	0.2	0.7	0.4	0.5	-1.1
Pavlov. Cond. lever latency	0.7	1.0	2.2	-0.6	0.8	0.0	-1.5	-0.8	-1.2	1.3
Pavlov. Cond. magazine entry latency	2.4	2.9	6.1	1.5	-1.9	-1.0	2.5	0.2	2.2	-1.6
Pavlov. Cond. change in total contacts	0.3	0.5	1.1	1.0	-0.4	0.0	1.1	0.3	0.9	-0.9
Pavlov. Cond. index score	1.3	1.8	3.8	1.4	-1.3	-0.6	1.9	0.2	1.6	-1.5
Pavlov. Cond. latency score	1.4	1.9	4.0	1.3	-1.4	-0.6	2.0	0.3	1.6	-1.6
Pavlov. Cond. lever contacts	1.0	1.4	3.2	0.7	-1.0	-0.2	1.8	0.8	1.4	-1.6
Pavlov. Cond. magazine entry number	1.7	2.1	4.1	-1.7	1.6	0.9	-2.0	0.2	-1.8	1.1
Pavlov. Cond. intertrial magazine entries	0.6	0.9	1.6	-1.0	1.3	1.1	-1.1	0.5	-0.9	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.0	4.2	1.5	-1.4	-0.6	2.0	0.2	1.7	-1.5
Pavlov. Cond. response bias	1.8	2.4	5.3	1.4	-1.5	-0.5	2.3	0.6	1.8	-2.0
Time in closed arm before self-admin	1.7	2.2	4.7	-1.5	2.2	1.7	-1.9	0.5	-1.2	0.7
Time in closed arm after self-admin	1.7	1.8	4.6	-0.8	2.1	2.1	-1.3	0.6	-0.7	0.5
Time in open arm before self-admin	0.3	0.4	0.7	0.8	-0.2	0.7	0.7	0.4	0.8	0.2
Time in open arm after self-admin	1.3	1.4	3.0	0.9	-1.7	-1.5	1.4	-0.4	0.9	-1.0
Bone: periosteal estimation	1.1	2.3	4.0	-2.0	1.9	2.0	-1.1	1.6	-0.7	0.2
Bone: periosteal perimeter	0.6	1.1	2.6	-0.8	0.5	1.0	0.6	1.6	0.2	-1.6
Bone: post-yield work	0.2	0.3	1.4	-0.4	0.3	0.1	-0.1	0.2	-0.8	-1.2
Progressive ratio test 1 active lever presses	0.6	0.8	1.5	-1.1	1.2	1.2	-0.6	0.9	-0.0	0.3
Progressive ratio test 1 breakpoint	0.6	0.8	1.5	-1.1	1.2	1.2	-0.6	1.0	0.0	0.3
Progressive ratio test 1 inactive lever presses	1.0	1.5	2.6	-0.7	1.6	1.0	-1.6	-0.3	-1.4	1.3
Progressive ratio test 2 active lever presses	0.8	0.9	2.1	-0.6	1.4	1.4	-1.0	0.4	-0.4	0.7
Progressive ratio test 2 breakpoint	0.7	0.8	1.9	-0.5	1.3	1.4	-0.9	0.4	-0.3	0.7
Progressive ratio test 2 inactive lever presses	1.9	3.1	5.3	-1.7	2.3	1.7	-2.3	0.3	-2.2	0.7
Incentive Sensitization - Responses	0.0	0.1	0.2	0.2	0.0	0.1	-0.2	-0.3	-0.1	0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	0.4	-0.1	-0.0	-0.2	-0.4	-0.1	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.6	-0.8	-0.4	-0.4	0.5	0.8	0.5	-0.2
Progressive ratio	0.2	0.4	1.2	1.0	-0.2	-0.7	0.1	-1.1	0.3	0.1
Food seeking constrained by brief footshock	1.5	1.9	5.2	0.9	-0.7	-2.0	-0.7	-2.3	-1.5	0.2
Seeking ratio, punishment vs. effort	0.4	0.6	1.1	-1.1	0.4	0.5	-0.8	0.5	-0.9	0.7
Retroperitoneal fat weight	0.5	2.2	3.6	-0.1	-1.5	-1.0	1.9	1.4	1.7	-1.9
Reaction time number correct	0.7	1.3	3.2	-0.4	1.3	0.6	-1.7	-0.2	-1.8	0.8
Reaction time mean minus median	1.6	3.9	8.2	0.1	-0.9	0.7	2.6	2.1	2.5	-2.9
Reaction time mean minus median AUC	0.7	1.8	4.0	1.1	-1.1	-0.1	2.0	0.5	1.5	-2.0
Reaction time num false alarms	0.5	0.7	1.6	0.8	-0.5	0.1	1.3	0.3	1.1	-1.1
Reaction time num false alarms AUC	0.3	0.5	1.7	0.6	-0.4	0.1	1.0	0.2	0.6	-1.3
Reaction time trials correct on left	0.7	1.3	3.2	-0.4	1.3	0.6	-1.7	-0.2	-1.8	0.8
Reaction time trials on left	0.6	1.2	2.8	-0.4	1.2	0.6	-1.6	-0.1	-1.7	0.8
Reaction time mean	2.9	4.6	9.6	2.1	-2.5	-1.1	3.0	-0.1	3.1	-1.2
Reaction time mean AUC	2.9	4.6	8.8	2.2	-2.6	-1.2	3.0	-0.3	2.9	-1.3
Median of all reaction times	3.2	4.6	7.9	2.5	-2.7	-1.7	2.6	-0.9	2.8	-0.4
Reaction time omissions	1.2	1.7	3.7	1.1	-1.5	-0.6	1.9	0.2	1.6	-1.5
Reaction time false alarm rate	1.0	1.4	3.1	0.7	-0.9	-0.2	1.8	0.4	1.4	-1.7
Reaction time premature initiation rate	0.3	0.5	1.0	0.3	-0.2	0.6	1.0	0.5	1.0	-0.8
Reaction time premature initiations	0.1	0.1	0.5	0.2	0.3	0.7	0.2	0.3	0.1	-0.4
Std. dev. reaction times	1.9	3.6	7.9	1.1	-1.7	-0.2	2.8	1.0	2.7	-2.2
Reaction time trials completed	0.6	1.2	2.8	-0.4	1.2	0.6	-1.6	-0.1	-1.7	0.8
Reaction time trials AUC	0.5	0.9	2.7	-0.2	1.0	0.4	-1.4	-0.3	-1.7	0.6
Run reversals in cocaine runway, females	0.7	0.7	1.8	0.8	-1.0	-1.3	0.5	-0.8	0.0	-0.9
Run reversals in cocaine runway, males	0.4	0.4	1.1	0.5	0.4	0.1	-0.7	-1.0	-0.9	-0.1
Latency to leave start box in cocaine runway	0.2	0.2	0.7	-0.1	-0.2	0.0	0.2	0.3	0.8	0.5
Latency to leave start box in cocaine runway, F	0.6	0.7	2.6	-1.0	0.5	0.6	-0.6	0.6	0.4	1.6
Latency to leave start box in cocaine runway, M	0.5	0.5	1.2	0.9	-0.7	-0.5	0.7	-0.3	0.4	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.1	0.4	0.5	0.0	0.0	-0.2	-0.6
Total sessions with >9 infusions	0.1	0.2	0.5	0.2	-0.5	-0.7	0.2	-0.4	0.3	0.3
Short access day 1 total inactive lever presses	0.3	0.4	1.2	-0.6	0.3	-0.2	-0.9	-0.4	-1.1	0.3
Short access day 10 total inactive lever presses	1.3	3.2	6.5	-2.3	1.4	0.7	-2.6	-0.0	-2.3	1.7
Short access day 1 total infusions	0.6	0.8	2.5	0.8	-1.2	-1.6	0.6	-1.0	0.3	-0.0
Short access day 10 total infusions	0.5	0.6	1.4	0.6	-1.0	-1.2	0.8	-0.3	0.1	-0.9
Short access total infusions	0.7	0.9	2.1	0.4	-1.3	-1.4	1.0	-0.4	0.9	-0.2
Short access day 1 locomotion	0.9	1.1	2.2	1.1	-0.8	-0.3	1.5	0.1	1.3	-1.3
Short access day 10 total locomotion	0.2	0.4	1.3	0.1	-0.1	-0.5	-0.6	-0.9	-1.2	-0.3
Short access total locomotion	0.8	0.9	1.6	0.7	-1.2	-1.0	1.3	-0.4	0.9	-1.0
One hour access (0.3 mA shock)	1.4	1.6	3.2	-0.5	1.8	1.4	-1.6	-0.3	-1.5	0.9
Compulsive drug intake	1.2	1.4	3.5	1.9	-1.2	-1.3	0.5	-1.6	0.2	0.5
One hour access (shock baseline)	0.9	1.4	3.4	-1.1	1.7	1.8	-0.6	1.2	-0.4	-0.4
Social response proportion	4.5	5.1	12.3	-2.3	2.7	3.5	-0.6	3.0	0.9	0.8
Social responses	1.2	1.6	3.9	-1.3	1.7	2.0	-0.6	1.4	-0.4	-0.4
Social time	1.4	2.0	4.3	2.1	-1.4	-0.9	1.6	-1.1	1.7	-0.0
Soleus weight	0.8	2.5	4.7	-2.2	1.7	1.5	-1.1	1.4	-1.7	-1.2
Bone: stiffness	0.5	0.9	2.4	-0.8	1.0	1.6	0.1	1.3	0.4	-0.1
Tibialis anterior weight	4.4	14.9	30.8	-5.6	4.3	4.8	-1.9	5.1	-1.0	-1.0
Time to tail flick, vehicle, before self-admin	1.4	1.5	5.2	0.5	-1.1	-0.4	1.7	0.6	2.3	-0.5
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.4	0.4	0.1	0.3	0.4	0.4	0.6	-0.5
Time to tail flick, test, before self-admin	1.6	1.7	3.0	-1.3	1.7	1.6	-1.5	0.9	-0.6	1.2
Time to tail flick, test, after self-admin	0.4	0.4	1.2	0.5	-0.7	-0.3	0.8	0.2	1.1	0.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.4	0.0	-0.3	-0.2	-0.4	-0.7	-0.5
Delta time to tail flick, test, before/after SA	1.2	1.2	2.4	1.2	-1.6	-1.5	1.1	-1.0	0.4	-0.6
Tibia length	3.9	10.7	20.3	-4.5	3.7	3.9	-2.9	2.9	-0.8	2.8
Ambulatory time before self-admin	0.6	0.8	2.0	0.9	-1.0	-0.4	1.4	0.2	0.8	-1.1
Ambulatory time after self-admin	0.3	0.4	0.9	0.9	-0.5	-0.5	0.7	-0.2	0.2	-0.9
Bone: tissue strength	0.9	0.9	2.2	-0.2	0.5	-0.5	-1.3	-0.9	-1.5	0.9
Total heroin consumption	3.2	3.8	6.5	2.3	-2.0	-1.7	2.6	-0.4	1.7	-2.1
Bone: trabecular number	1.9	3.2	6.7	-2.6	1.9	1.6	-1.6	1.8	-1.8	-0.4
Bone: trabecular spacing	2.1	2.7	4.6	2.1	-2.0	-2.1	1.2	-2.0	0.7	-0.2
Bone: trabecular thickness	2.4	3.0	6.7	-2.6	1.6	1.5	-1.0	2.1	-1.4	-1.4
Bone: trabecular tissue density	2.1	3.2	9.3	-0.1	-0.4	1.1	2.3	2.1	3.0	-1.4
Water consumed over 24 hours	2.6	3.5	5.9	-1.9	2.4	1.9	-2.2	1.0	-1.4	1.9
Number of responses in last shaping day	0.3	0.3	0.7	0.5	-0.6	-0.8	0.6	-0.4	0.4	-0.5