Hub : Genes

Camsap3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	intron excision ratio	chr12_1657278_1657543	0.07	0.04	2.2e-04	0.04	0.02	0.03	0.04	2.1e-05	1.1e-03	1.1e-04	4.8e-05
2	PL	intron excision ratio	chr12_1656071_1657543	0.04	0.02	1.5e-03	0	0.02	0.02	0.01	2.0e-01	1.6e-03	1.7e-03	1.7e-02
3	Brain	gene expression	Camsap3	0.05	0.03	1.6e-03	0.02	0.01	0.01	0.02	2.9e-03	1.7e-02	8.0e-02	1.2e-02
4	Liver	gene expression	Camsap3	0.13	0.07	6.1e-06	-0	0.02	0.02	0	4.7e-01	3.6e-03	2.3e-03	1.3e-01
5	NAcc	gene expression	Camsap3	0.05	0.03	1.9e-03	0	0.01	0	0	1.2e-01	3.9e-02	1.4e-01	1.1e-01
6	PL	intron excision ratio	chr12_1656071_1657231	0.03	0.02	7.1e-04	0.03	0.03	0.03	0.03	3.7e-04	3.7e-04	2.6e-04	7.5e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	2.8	4.6	11.0	-2.9	-2.3	-1.4	3.3	0.6	-0.9
Area under the delay curve	2.8	2.9	7.0	1.4	2.2	-0.7	-2.6	0.2	1.8
BMI with tail	0.9	3.0	12.5	-1.7	0.1	-3.5	-0.4	1.5	0.6
BMI without tail	2.2	4.5	10.5	-2.7	-0.8	-3.2	-0.2	2.8	-0.8
Body weight	7.2	30.2	65.2	-7.2	-3.8	-8.1	2.0	6.2	-2.7
Weight adjusted by age	0.8	0.9	2.1	-0.7	-1.4	-0.3	1.3	0.3	-0.8
Bone surface	2.4	4.2	8.8	-3.0	-1.9	-2.4	2.3	1.3	-0.7
Bone volume	1.4	2.4	6.5	-2.1	-1.5	-1.1	2.6	0.1	-0.1
Breakpoint value in progressive ratio session	1.2	1.3	2.4	0.0	1.4	-1.4	-1.0	0.4	1.5
Number of licking bursts	3.1	3.6	9.8	-1.4	-2.5	0.4	0.7	1.8	-3.1
Context. condit. distance diff. score	1.8	2.2	6.2	-2.1	0.2	-2.5	0.5	1.4	0.7
Locomotion velocity, session 1	0.5	0.6	1.1	0.7	1.1	-0.2	-1.0	-0.2	0.8
Locomotion distance, session 1	0.6	0.8	1.5	1.2	1.0	0.8	-0.7	-0.7	0.7
Locomotion velocity, session 2	0.3	0.3	1.2	0.3	0.3	-0.3	-1.1	0.6	-0.3
Locomotion distance, session 2	0.3	0.4	1.3	0.8	0.5	1.2	-0.4	-0.4	-0.0
Locomotion velocity, session 3	0.1	0.2	0.3	-0.5	0.4	-0.4	0.0	0.2	0.6
Locomotion distance, session 3	0.4	0.5	1.1	-0.3	-0.3	1.1	1.1	-0.5	-0.1
Stereotopy head waving bouts, day 3	1.7	2.0	3.1	-1.8	-1.6	-1.3	1.5	1.1	-1.1
Stereotopy head waving duration, day 3	0.0	0.1	0.2	0.1	-0.3	-0.4	0.1	-0.1	-0.1
Locomotion velocity, session 7	1.4	1.6	5.0	0.9	1.5	-0.6	-2.2	0.6	0.8
Locomotion distance, session 7	0.4	0.5	1.3	0.1	1.0	-0.0	-1.2	0.6	0.6
Stereotopy head waving bouts, day 7	0.3	0.4	0.6	0.8	0.7	0.3	-0.2	-0.7	0.6
Stereotopy head waving duration, day 7	0.3	0.3	0.8	0.9	0.6	0.3	-0.5	-0.6	0.4
Locomotion velocity, session 8	0.4	0.5	1.2	-0.2	0.3	-1.1	-1.0	0.9	0.0
Locomotion distance, session 8	0.6	0.9	2.6	-1.2	0.1	-1.6	-0.1	1.2	0.2
Degree of sensitization distance	1.0	1.0	3.3	1.0	1.1	-0.1	-1.8	0.4	0.4
Degree of sensitization stereotypy	0.4	0.4	0.7	0.7	0.9	0.2	-0.6	-0.5	0.7
Conditioned locomotion	0.4	0.5	1.2	-0.1	-0.2	0.6	1.1	-1.0	0.4
Cocaine response after cond. corrected	0.2	0.2	0.5	0.7	-0.1	-0.3	-0.4	-0.5	0.2
Cocaine response after cond. not corrected	0.6	0.6	1.3	0.7	0.7	-0.7	-0.6	-0.7	1.1
Cocaine response before conditioning	0.9	1.1	3.5	-0.2	1.5	-0.7	-0.0	-0.2	1.9
Saline control response	2.7	3.5	6.2	-2.5	-2.0	-0.8	1.5	1.9	-2.1
Bone: connectivity density	4.1	6.4	12.7	-3.6	-2.4	-2.6	2.8	1.8	-1.4
Bone: cortical apparent density	0.7	0.9	2.4	1.1	1.1	0.1	-1.5	-0.0	0.8
Bone: cortical area	0.9	1.4	3.8	-1.5	0.2	-1.9	-0.3	1.5	0.4
Bone: cortical porosity	0.1	0.1	0.1	-0.1	-0.4	0.1	0.4	0.0	-0.2
Bone: cortical porosity	0.1	0.1	0.2	0.3	0.3	0.5	0.0	-0.3	0.4
Bone: cortical thickness	0.8	1.3	3.1	-1.4	-0.1	-1.8	-0.3	1.6	0.1
Bone: cortical thickness	0.8	0.9	2.5	-1.4	-0.6	-0.6	0.1	1.6	-0.7
Bone: cortical tissue density	0.6	0.8	2.0	1.1	1.1	0.2	-1.4	-0.2	0.8
Condit. Reinf. active minus inactive responses	0.9	1.0	1.7	1.1	1.3	0.2	-1.0	-0.8	1.2
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.7	0.8	1.3	-0.3	-1.1	-0.5	1.2
Condit. Reinf. active responses	0.6	0.7	1.5	0.8	1.2	0.2	-0.6	-0.7	1.2
Condit. Reinf. inactive responses	0.4	0.4	0.8	0.6	0.9	0.7	-0.2	-0.5	0.8
Incentive salience index mean	0.8	1.0	2.0	0.9	1.3	0.5	-0.4	-1.0	1.4
Condit. Reinf. lever presses	0.5	0.7	1.9	0.5	1.1	0.5	0.1	-0.9	1.4
Condit. Reinf. active minus inactive responses	1.7	2.2	5.1	-1.3	0.3	-2.3	-1.1	2.2	-0.3
Condit. Reinf. active-inactive response ratio	1.5	1.5	3.4	-0.6	0.5	-1.7	-1.5	1.9	-0.2
Condit. Reinf. active responses	1.4	2.0	5.1	-1.4	0.7	-2.3	-0.8	1.8	0.4
Condit. Reinf. inactive responses	0.3	0.3	0.7	-0.9	0.2	-0.6	0.6	0.2	0.5
Condit. Reinf. lever presses	0.4	0.5	1.0	-0.7	0.8	-1.0	0.3	0.1	1.0
Condit. Reinf. lever reinforcers received	1.2	1.7	4.1	-1.1	0.9	-2.0	-0.9	1.7	0.5
Conditioned reinforcement - actives	4.3	4.3	7.9	-2.8	-1.7	-1.7	0.7	2.7	-2.0
Conditioned reinforcement - inactives	0.9	1.0	2.1	-0.9	-1.4	0.4	1.0	0.6	-1.4
Conditioned locomotion	1.8	2.2	5.8	-2.4	-1.0	-1.3	1.1	1.7	-0.9
Patch foraging indifference point 0 sec	1.2	1.9	5.1	-0.3	-1.4	1.5	2.3	-1.1	-0.6
Patch foraging indifference point AUC	1.0	1.1	1.7	-1.3	-1.1	-1.0	1.0	1.0	-1.0
Delay disc. indifference point, 0s delay	2.2	2.4	7.6	0.6	1.4	-1.7	-2.8	1.0	0.8
Delay disc. indifference point, 16s delay	0.9	0.9	2.6	0.8	1.2	-0.3	-1.6	0.2	0.9
Delay disc. indifference point, 2s delay	4.9	5.5	10.5	2.0	3.2	-0.6	-2.9	-0.9	3.0
Delay disc. indifference point, 24s delay	0.8	0.8	2.3	1.0	1.0	0.2	-1.5	0.1	0.6
Delay disc. indifference point, 4s delay	2.6	2.8	5.0	1.6	2.2	-0.4	-2.0	-0.6	2.2
Delay disc. indifference point, 8s delay	0.9	1.0	1.9	0.9	1.4	-0.1	-1.4	0.0	1.1
Indifference point function ln k	0.2	0.3	1.0	-0.3	-0.5	1.0	0.7	0.0	-0.5
Indifference point function log k	0.2	0.3	1.0	-0.3	-0.5	1.0	0.7	0.0	-0.5
Patch foraging total patch changes 0 sec	1.5	2.5	7.0	-0.4	-1.6	1.7	2.7	-1.3	-0.7
Patch foraging total patch changes 12 sec	0.5	0.7	2.3	-0.4	-0.9	0.4	1.5	-0.7	-0.1
Patch foraging total patch changes 18 sec	1.5	2.0	5.6	-0.6	-1.8	0.9	2.4	-0.7	-1.2
Patch foraging total patch changes 24 sec	1.3	1.6	5.8	-0.5	-0.8	1.5	2.4	-0.9	-0.1
Patch foraging total patch changes 6 sec	1.1	1.6	5.7	-0.8	-1.5	0.6	2.4	-0.7	-0.7
Patch foraging time to switch 0 sec	2.6	4.0	8.0	2.6	2.0	0.1	-2.8	-1.3	1.8
Patch foraging water rate 0 sec	3.9	6.3	15.2	-3.0	-2.7	0.1	3.9	1.1	-2.1
Patch foraging water rate 12 sec	0.5	0.8	2.6	-1.1	-0.6	0.6	1.6	0.3	-0.5
Patch foraging water rate 18 sec	0.2	0.2	0.5	-0.3	0.7	0.6	0.2	0.3	0.5
Patch foraging water rate 24 sec	1.6	2.2	5.1	-2.3	-1.3	-0.3	1.8	1.3	-1.2
Patch foraging water rate 6 sec	0.7	1.0	4.0	-1.3	-0.4	0.5	2.0	-0.2	0.1
Seeking ratio, delayed vs. immediate footshock	1.2	1.4	4.4	1.2	-0.5	2.1	0.1	-1.3	-0.7
Distance traveled before self-admin	0.9	0.9	2.2	0.8	1.5	-0.1	-1.2	-0.2	1.1
Distance traveled after self-admin	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.3	0.3	0.2
Extensor digitorum longus weight	2.6	10.3	23.7	-4.9	-1.8	-4.3	2.0	3.4	-0.9
Bone: elastic displacement	0.4	0.5	0.8	-0.8	-0.9	-0.3	0.6	0.6	-0.7
Bone: elastic work	2.4	3.0	6.5	-2.6	-1.7	-1.4	1.6	1.6	-1.2
Bone: endosteal estimation	1.1	2.3	4.1	-1.9	-1.8	-0.1	2.0	0.7	-1.5
Bone: endosteal perimeter	0.5	1.1	3.4	-1.8	-0.5	-0.6	1.5	0.6	-0.1
Epididymis fat weight	0.3	0.8	2.0	-0.2	1.0	-1.1	0.1	-0.5	1.4
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	-0.4	0.4	-0.3	-0.3	0.6	-0.0
Delta time in open arm before/after self-admin	2.2	2.1	3.9	1.8	1.3	1.1	-0.6	-2.0	1.5
Diff in mean of infusions in LGA sessions	0.2	0.2	0.7	-0.2	0.5	-0.3	0.3	-0.2	0.8
Delay discount exponential model param	2.9	3.1	6.5	-1.4	-2.4	0.6	2.6	0.0	-2.0
Extinction: sum of active levers before priming	1.4	1.4	2.4	1.4	1.5	0.2	-1.0	-0.9	1.5
Active lever presses in extinction session 6	0.1	0.1	0.2	-0.3	0.0	-0.4	0.3	-0.0	0.3
Bone: final force	1.8	2.9	5.8	-2.2	-1.2	-1.9	0.0	2.4	-1.3
Bone: final moment	1.5	2.5	4.8	-2.0	-1.2	-1.6	0.1	2.2	-1.3
Food consumed during 24 hour testing period	0.7	0.8	1.5	-0.6	-1.2	0.7	1.1	0.3	-1.2
Glucose	0.6	0.8	2.5	1.1	1.0	-0.2	-1.6	-0.1	0.6
Heart weight	0.5	0.7	1.8	-1.0	-0.3	0.0	0.1	1.3	-1.1
Delay discount hyperbolic model param	3.0	3.2	6.7	-1.5	-2.4	0.5	2.6	0.1	-2.0
Intermittent access intake day 1-15 change	2.3	2.3	3.9	-1.6	-2.0	0.0	1.6	1.0	-1.9
Intermittent access intake escalation	1.9	1.8	2.7	-1.7	-1.6	-0.2	1.5	1.0	-1.5
Intermittent access intake escalation 2	0.5	0.5	1.1	-0.6	-0.8	0.5	1.1	0.1	-0.8
Intermitt. access day 1 inactive lever presses	1.5	1.6	2.6	-0.9	-1.6	0.9	1.6	0.4	-1.6
Intermitt. access day 15 inactive lever presses	0.3	0.3	0.6	0.6	-0.7	0.6	0.4	-0.8	-0.3
Intermitt. access escalation Index	0.3	0.3	0.6	0.3	0.7	0.5	0.3	-0.4	0.7
Intermittent access day 1 total infusions	0.8	1.0	2.2	0.7	1.5	0.5	-1.1	-0.5	1.1
Intermittent access day 15 total infusions	0.1	0.2	0.3	-0.6	-0.1	0.4	0.6	0.1	-0.3
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	0.1	0.2	0.5	0.0	-0.4	0.1
Intermittent access total infusions	0.5	0.6	1.3	0.6	1.2	0.2	-0.8	-0.5	0.9
Intermittent access day 1 locomotion	2.6	2.8	5.7	1.3	2.4	0.8	-1.1	-1.5	2.3
Intermittent access day 15 total locomotion	0.3	0.3	0.9	-0.5	0.9	0.3	0.3	-0.1	0.7
Intermittent access total locomotion	1.4	1.5	4.1	0.7	2.0	0.6	-0.8	-0.8	1.7
Intermittent access standard deviation	0.9	1.0	2.5	-0.4	-1.6	0.4	1.3	-0.2	-1.1
Left kidney weight	6.5	18.2	34.1	-5.8	-3.7	-4.6	2.4	4.9	-3.2
Right kidney weight	5.2	14.7	25.2	-5.0	-3.4	-4.6	2.0	4.3	-2.9
Cocaine induced anxiety	0.9	1.1	2.8	0.5	1.5	0.1	0.0	-1.0	1.7
Post-drug Anxiety	3.8	4.2	7.8	2.2	2.8	0.4	-2.1	-1.5	2.4
Baseline Anxiety	2.9	3.1	6.5	2.5	1.7	0.4	-2.6	-1.0	1.2
Tail length	4.9	14.8	26.5	-5.2	-2.5	-5.0	1.0	5.0	-2.4
Length with tail	9.0	33.0	58.8	-7.7	-4.4	-7.2	2.4	7.0	-3.7
Length without tail	4.2	9.2	20.8	-4.0	-2.1	-4.6	1.4	3.2	-1.1
Times rat made contact with spout	0.8	1.0	2.4	-1.2	-0.6	-0.9	-0.2	1.6	-0.9
Lifetime Intake	0.6	0.6	1.0	0.8	1.0	0.2	-1.0	-0.6	0.8
Liver weight, left	1.7	2.6	6.0	-1.5	-2.3	0.1	2.4	0.1	-1.6
Liver weight, right	2.3	3.8	8.2	-2.9	-1.7	-2.0	2.1	1.5	-1.1
Locomotor activity	1.7	2.7	6.1	-2.4	-0.7	-1.7	0.3	2.5	-1.0
Locomotor testing distance	0.9	1.5	2.6	-1.6	-1.4	-0.6	1.3	1.0	-1.2
Locomotor testing rearing	0.3	0.5	1.6	0.1	-0.6	0.6	1.3	-0.9	-0.1
Locomotion in novel chamber	0.7	0.8	1.6	-1.3	-0.8	0.3	0.9	0.8	-1.1
Locomotion in novel chamber post-restriction	1.7	2.0	4.1	-2.0	-0.9	-1.3	0.9	1.9	-0.8
Fecal boli incidents, locomotor time 1	1.0	1.0	2.5	-1.6	-0.5	-1.1	0.7	1.2	-0.5
Change in fecal boli incidents, locomotor task	0.3	0.3	0.8	0.9	-0.1	0.6	-0.5	-0.6	-0.2
Time >=10cm from walls, locomotor time 1	2.7	2.7	5.0	1.6	2.2	-0.1	-1.4	-1.3	2.2
Bouts of movement, locomotor time 1	1.1	1.2	2.1	-1.4	-0.9	-0.9	0.9	1.3	-1.0
Total resting periods, locomotor time 1	0.8	0.9	1.6	-1.3	-0.6	-0.9	0.7	1.2	-0.7
Rest time, locomotor task time 1	0.3	0.4	0.9	-1.0	-0.2	-0.8	0.4	0.5	-0.2
Distance moved, locomotor task time 1	0.3	0.3	0.6	0.8	0.5	0.2	-0.7	-0.0	0.5
Vertical activity count, locomotor time 1	0.2	0.2	0.7	-0.5	-0.3	-0.3	-0.1	0.9	-0.4
Time >=10cm from walls, locomotor time 2	1.0	1.1	2.5	0.1	1.1	-1.6	-0.9	0.1	1.4
Bouts of movement, locomotor time 2	0.7	0.7	1.6	-1.3	-0.5	-0.9	1.0	0.7	-0.1
Total resting periods, locomotor time 2	0.6	0.7	1.5	-1.2	-0.6	-0.8	1.1	0.6	-0.1
Rest time, locomotor task time 2	0.3	0.3	0.7	0.3	0.6	0.1	0.2	-0.8	0.9
Distance moved, locomotor task time 2	0.5	0.6	1.6	-0.1	-1.0	0.2	-0.1	0.9	-1.3
Vertical activity count, locomotor time 2	3.0	3.3	5.9	-2.0	-2.1	-0.5	1.0	2.1	-2.4
Light reinforcement 1	1.0	1.9	4.7	1.0	1.9	-0.6	-2.2	-0.1	1.3
Light reinforcement 2	0.2	0.2	0.5	0.3	-0.4	0.7	-0.1	-0.1	-0.7
Bone: marrow area	1.1	2.5	4.4	-1.9	-1.9	-0.1	2.1	0.7	-1.6
Bone: maximum diameter	0.7	1.2	3.2	-1.8	-0.8	-1.1	1.1	1.0	-0.4
Bone: maximum force	1.4	2.4	5.2	-2.3	-1.3	-1.5	0.9	1.8	-1.1
Bone: maximum moment	1.2	2.1	4.4	-2.1	-1.3	-1.2	1.0	1.6	-1.1
Mean time between licks in bursts	0.9	1.3	2.6	1.5	0.6	1.6	-0.0	-1.5	0.6
Mean num. licks in bursts	0.8	1.0	3.0	0.4	1.3	-0.7	-0.3	-0.7	1.7
Cd content in liver	0.9	1.0	4.0	0.6	-0.1	2.0	0.8	-0.9	-0.4
Co content in liver	1.5	1.7	3.6	-0.8	-1.9	0.7	1.7	0.1	-1.6
Cu content in liver	0.4	0.5	1.6	-0.2	-0.2	0.8	1.3	-0.9	0.2
Fe content in liver	1.0	1.2	2.9	-1.7	0.2	-1.3	1.2	0.6	0.9
K content in liver	0.1	0.1	0.4	0.1	0.3	-0.6	0.1	-0.2	0.6
Mg content in liver	0.3	0.3	0.6	-0.6	-0.5	-0.8	0.1	0.6	-0.3
Mn content in liver	0.2	0.3	0.6	0.6	-0.4	0.8	-0.0	-0.5	-0.6
Na content in liver	0.3	0.3	0.8	-0.2	0.5	-0.9	-0.6	0.4	0.4
Rb content in liver	1.8	2.2	4.1	1.8	1.4	0.8	-0.2	-2.0	1.8
Se content in liver	1.6	2.0	4.8	-0.2	1.7	-2.0	-0.7	0.1	2.2
Sr content in liver	1.7	1.5	3.7	-0.4	-1.9	0.8	1.3	0.2	-1.7
Zn content in liver	2.7	3.0	5.4	-1.9	-2.3	-0.8	2.1	1.1	-1.7
Bone: minimum diameter	0.0	0.1	0.2	-0.2	-0.2	0.5	0.2	0.0	-0.2
Time in familiar zone, hab. session 1	0.8	0.7	1.5	0.7	-0.6	1.2	0.7	-1.2	-0.3
Time in novel zone, hab. session 1	0.6	0.5	1.3	-0.7	0.2	-1.2	-0.6	1.0	0.1
Total zone transitions, hab. session 1	0.9	1.3	2.5	1.3	1.6	0.5	-1.2	-0.6	1.2
Total locomotion distance, hab. session 1	0.9	1.3	2.7	1.1	1.6	-0.2	-0.9	-0.8	1.7
Locomotion velocity, hab. session 1	1.5	2.1	4.1	1.5	2.0	0.2	-1.3	-1.1	1.9
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.4	0.2	-0.2	-0.2	-0.5	0.4
Time in novel zone, hab. session 2	0.1	0.1	0.3	0.2	0.5	0.6	-0.3	0.0	0.2
Total zone transitions, hab. session 2	0.3	0.4	1.2	-0.4	-0.4	-0.4	-0.5	1.1	-0.9
Total locomotion distance, hab. session 2	0.1	0.1	0.3	0.4	0.3	0.1	-0.5	0.1	0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.3	0.2	0.1	-0.5	0.2	-0.1
Novel to familiar place preference ratio	0.2	0.2	0.5	0.0	-0.1	-0.3	-0.7	0.7	-0.6
Novelty place preference	0.2	0.2	0.6	0.3	0.1	-0.1	-0.8	0.4	-0.4
Time in novel zone, NPP test	0.2	0.2	0.5	0.2	0.0	-0.3	-0.7	0.5	-0.5
Total zone transitions, NPP test	0.1	0.2	0.3	-0.3	0.3	-0.6	-0.4	0.5	0.1
Total locomotion distance, NPP test	0.8	1.2	2.6	0.3	1.6	-0.9	-1.0	-0.1	1.6
Locomotion velocity, NPP test	0.6	0.8	1.8	0.0	1.3	-0.9	-0.7	0.2	1.3
Intraocular pressure	0.9	1.2	3.4	-1.8	-0.8	-0.6	1.6	0.7	-0.2
Delta distance traveled before/after self-admin	0.6	0.6	1.2	-0.8	-1.1	0.1	0.7	0.5	-1.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.3	-0.1	-0.5	0.5	0.5	-0.2	-0.5
Parametrial fat weight	0.2	0.4	1.2	0.1	-1.1	-0.3	0.0	0.5	-1.0
Pavlov. Cond. lever latency	2.1	2.7	3.9	-2.0	-1.9	-1.4	1.2	1.5	-1.7
Pavlov. Cond. magazine entry latency	0.2	0.2	0.5	-0.6	0.2	-0.5	-0.3	0.7	-0.0
Pavlov. Cond. change in total contacts	1.5	1.6	2.9	1.1	1.7	-0.6	-1.7	-0.2	1.4
Pavlov. Cond. index score	0.4	0.5	1.2	0.4	1.1	-0.0	-0.7	-0.2	1.0
Pavlov. Cond. latency score	0.7	0.8	1.9	0.7	1.4	0.1	-1.0	-0.4	1.2
Pavlov. Cond. lever contacts	1.7	2.0	3.0	1.6	1.7	0.9	-1.1	-1.3	1.6
Pavlov. Cond. magazine entry number	0.3	0.3	0.7	0.8	-0.4	0.7	0.0	-0.7	-0.4
Pavlov. Cond. intertrial magazine entries	0.6	0.8	2.6	0.9	0.2	1.6	0.1	-1.0	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.9	0.4	0.9	0.0	-0.6	-0.3	0.9
Pavlov. Cond. response bias	0.2	0.2	0.6	-0.2	0.8	-0.4	-0.3	0.1	0.8
Pavlov. Cond. lever latency	1.0	1.3	3.0	-0.2	-1.7	1.2	1.2	-0.4	-1.4
Pavlov. Cond. magazine entry latency	2.5	2.9	6.0	1.5	2.5	-0.2	-2.1	-0.5	2.1
Pavlov. Cond. change in total contacts	0.4	0.5	1.3	-0.0	1.2	-0.6	-0.8	0.4	0.8
Pavlov. Cond. index score	1.3	1.7	4.4	0.7	2.1	-0.4	-1.5	-0.1	1.7
Pavlov. Cond. latency score	1.4	1.8	4.4	0.8	2.1	-0.4	-1.5	-0.2	1.8
Pavlov. Cond. lever contacts	1.1	1.5	3.7	0.4	1.9	-0.9	-1.0	-0.2	1.9
Pavlov. Cond. magazine entry number	1.7	2.1	4.6	-1.3	-2.1	-0.2	1.7	0.4	-1.7
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	-1.2	-1.1	-0.4	0.8	0.9	-1.0
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.8	4.4	0.8	2.1	-0.4	-1.6	-0.0	1.7
Pavlov. Cond. response bias	1.8	2.4	6.1	0.8	2.5	-0.8	-1.4	-0.3	2.3
Time in closed arm before self-admin	1.8	2.0	3.3	-1.6	-1.8	-0.4	1.4	1.2	-1.7
Time in closed arm after self-admin	1.1	1.1	2.1	-1.5	-1.0	-0.0	1.0	1.3	-1.1
Time in open arm before self-admin	0.2	0.2	0.5	-0.3	0.2	-0.4	-0.5	0.7	-0.2
Time in open arm after self-admin	0.2	0.3	0.4	0.6	0.5	-0.2	-0.4	-0.6	0.6
Bone: periosteal estimation	1.0	2.0	5.0	-2.2	-1.2	-1.2	1.1	1.5	-0.9
Bone: periosteal perimeter	0.5	0.8	1.9	-1.4	0.5	-1.1	0.4	0.7	0.8
Bone: post-yield work	0.3	0.4	1.2	-0.7	-0.1	-0.3	1.1	-0.3	0.4
Progressive ratio test 1 active lever presses	0.5	0.5	0.9	-0.9	-0.6	-0.4	0.0	0.9	-0.9
Progressive ratio test 1 breakpoint	0.6	0.6	1.3	-0.9	-0.6	-0.5	-0.1	1.1	-1.0
Progressive ratio test 1 inactive lever presses	1.4	1.5	2.4	-1.5	-1.3	0.0	1.1	1.1	-1.5
Progressive ratio test 2 active lever presses	0.9	1.0	2.4	-1.5	-0.4	-0.6	0.2	1.5	-0.9
Progressive ratio test 2 breakpoint	0.6	0.7	2.0	-1.2	-0.1	-0.4	-0.2	1.4	-0.8
Progressive ratio test 2 inactive lever presses	3.3	3.8	6.8	-2.6	-2.0	0.1	2.5	1.3	-2.0
Incentive Sensitization - Responses	0.0	0.1	0.1	-0.3	0.4	0.2	0.1	0.2	0.1
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.3	0.4	0.3	0.1	0.2	0.1
Sum of active levers in priming session hrs 5-6	1.4	1.4	2.6	1.3	1.3	-0.4	-1.0	-0.9	1.6
Progressive ratio	0.4	0.5	1.5	0.9	0.0	1.2	-0.1	-0.8	0.0
Food seeking constrained by brief footshock	1.6	2.0	5.0	0.7	-0.7	2.2	1.5	-1.9	-0.2
Seeking ratio, punishment vs. effort	0.4	0.5	1.1	-0.9	-0.8	-0.3	1.1	0.2	-0.4
Retroperitoneal fat weight	2.0	6.5	12.3	2.5	3.2	-0.9	-2.4	-2.0	3.5
Reaction time number correct	1.1	1.6	3.5	-1.3	-1.5	-0.1	1.9	0.5	-1.3
Reaction time mean minus median	3.0	3.9	7.0	0.2	2.6	-2.2	-2.1	0.8	2.6
Reaction time mean minus median AUC	1.4	1.8	4.2	0.8	2.0	-0.6	-1.3	-0.1	2.0
Reaction time num false alarms	0.6	0.9	2.4	0.2	1.6	-0.2	-1.1	0.3	1.2
Reaction time num false alarms AUC	0.5	0.7	2.0	0.0	1.4	-0.2	-0.5	0.0	1.3
Reaction time trials correct on left	1.1	1.6	3.5	-1.3	-1.5	-0.1	1.9	0.5	-1.3
Reaction time trials on left	1.0	1.5	3.2	-1.3	-1.5	-0.1	1.8	0.5	-1.2
Reaction time mean	3.6	5.0	9.6	2.6	2.8	0.4	-3.1	-0.8	2.2
Reaction time mean AUC	3.7	5.0	8.5	2.6	2.8	0.5	-2.9	-0.9	2.3
Median of all reaction times	3.9	5.4	9.5	3.1	2.6	1.2	-3.0	-1.3	1.9
Reaction time omissions	1.5	2.0	4.1	1.3	2.0	-0.3	-1.6	-0.5	1.8
Reaction time false alarm rate	1.1	1.6	4.0	0.5	2.0	-0.3	-1.4	-0.1	1.8
Reaction time premature initiation rate	0.3	0.4	0.9	0.1	0.8	-0.6	-1.0	0.5	0.6
Reaction time premature initiations	0.1	0.2	0.4	-0.4	0.1	-0.6	-0.1	0.6	0.0
Std. dev. reaction times	2.6	3.7	7.1	1.4	2.7	-1.0	-2.4	-0.1	2.5
Reaction time trials completed	1.0	1.5	3.2	-1.3	-1.5	-0.1	1.8	0.5	-1.2
Reaction time trials AUC	0.8	1.2	3.2	-1.1	-1.3	0.1	1.8	0.3	-1.0
Run reversals in cocaine runway, females	0.4	0.4	0.9	0.7	0.3	0.7	0.2	-0.9	0.5
Run reversals in cocaine runway, males	0.7	0.7	1.2	-0.5	-0.8	1.1	1.0	0.2	-1.0
Latency to leave start box in cocaine runway	0.5	0.5	2.2	0.3	0.3	-0.6	-1.5	0.5	-0.1
Latency to leave start box in cocaine runway, F	0.4	0.5	0.7	-0.1	-0.7	-0.7	-0.7	0.8	-0.9
Latency to leave start box in cocaine runway, M	0.5	0.5	1.4	0.4	1.2	0.3	-0.6	-0.3	0.9
Std. dev. time between licks in bursts	0.1	0.1	0.4	-0.7	0.2	0.2	0.4	0.3	0.2
Total sessions with >9 infusions	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.5	0.2	0.3
Short access day 1 total inactive lever presses	0.2	0.3	0.6	-0.2	-0.7	0.5	0.4	0.1	-0.8
Short access day 10 total inactive lever presses	2.2	2.5	4.7	-1.7	-2.2	-0.1	2.1	0.6	-1.6
Short access day 1 total infusions	1.1	1.1	2.6	1.6	0.3	1.0	-0.5	-1.6	0.6
Short access day 10 total infusions	0.7	0.8	1.4	1.0	1.0	0.6	-0.5	-1.2	1.0
Short access total infusions	0.6	0.7	1.8	1.2	0.7	0.0	-1.3	-0.6	0.5
Short access day 1 locomotion	1.5	1.6	3.4	1.3	1.8	0.2	-1.8	-0.3	1.2
Short access day 10 total locomotion	0.7	0.7	1.9	0.6	0.5	1.0	0.4	-1.4	0.8
Short access total locomotion	1.5	1.5	2.5	1.3	1.6	0.3	-1.2	-1.1	1.4
One hour access (0.3 mA shock)	0.7	0.9	1.3	-0.8	-0.8	1.1	1.0	0.4	-1.2
Compulsive drug intake	1.6	1.6	3.7	1.8	0.6	1.9	-0.5	-1.4	0.4
One hour access (shock baseline)	0.9	1.0	2.9	-1.7	-0.4	-0.8	0.8	1.3	-0.5
Social response proportion	4.3	4.6	11.6	-2.3	-0.5	-2.8	-1.2	3.4	-1.1
Social responses	1.3	1.7	4.4	-2.1	-0.5	-1.3	0.6	1.8	-0.6
Social time	1.5	2.0	4.1	1.7	1.7	1.2	-2.0	-0.6	0.9
Soleus weight	0.8	2.2	6.1	-2.5	-1.1	-1.0	2.0	0.9	-0.3
Bone: stiffness	0.5	0.7	1.7	-1.2	0.0	-1.1	-0.1	1.3	-0.1
Tibialis anterior weight	3.4	11.7	25.7	-4.9	-1.6	-5.1	1.3	3.9	-0.8
Time to tail flick, vehicle, before self-admin	1.7	1.7	5.7	1.1	1.6	-0.5	-2.4	0.2	0.8
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.8	0.3	0.9	-0.0	-0.9	0.1	0.4
Time to tail flick, test, before self-admin	0.9	0.8	1.2	-1.1	-1.0	-0.8	0.4	1.0	-1.0
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.1	0.4	-0.7	-0.8	0.1	0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.7	0.2	-0.0	0.8	0.8	-0.8	0.2
Delta time to tail flick, test, before/after SA	0.7	0.6	1.1	0.8	0.7	0.4	-0.2	-1.1	1.0
Tibia length	3.0	8.5	12.7	-3.4	-2.9	-2.8	0.4	3.6	-3.1
Ambulatory time before self-admin	1.2	1.3	3.6	0.3	1.9	-0.5	-1.1	-0.2	1.6
Ambulatory time after self-admin	0.3	0.3	0.8	0.1	0.9	-0.4	-0.5	-0.1	0.8
Bone: tissue strength	0.9	0.9	1.8	-0.0	-1.3	0.8	1.3	-0.7	-0.9
Total heroin consumption	3.4	3.9	7.9	1.9	2.8	0.6	-1.4	-1.6	2.7
Bone: trabecular number	2.3	3.6	7.5	-2.7	-1.9	-1.9	2.2	1.2	-1.0
Bone: trabecular spacing	2.1	2.8	6.1	2.5	1.3	1.9	-1.0	-1.8	1.1
Bone: trabecular thickness	2.2	2.6	5.8	-2.4	-1.2	-1.9	2.0	1.0	-0.1
Bone: trabecular tissue density	2.6	3.7	8.6	0.4	2.5	-1.6	-2.9	1.2	1.8
Water consumed over 24 hours	2.7	3.2	4.7	-2.2	-2.1	-0.6	1.4	1.9	-2.1
Number of responses in last shaping day	0.1	0.1	0.2	-0.2	-0.4	0.3	0.4	0.1	-0.4