Hub : Genes

Calr4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose mRNA stability Calr4 0.16 0.1 1.2e-11 0.06 0.08 0.08 0.07 1.9e-07 7.3e-09 6.7e-09 1.0e-08
2 Adipose alternative TSS XM_063288592.1 0.06 0.04 3.8e-04 -0 0.01 0.01 0 4.4e-01 8.6e-03 4.9e-02 1.2e-01
3 Adipose alternative TSS XM_063288592.1 0.07 0.05 9.9e-05 0 0.02 0.01 0.01 2.4e-01 2.0e-03 1.3e-02 4.4e-02
4 Adipose isoform ratio XM_063288592.1 0.11 0.07 2.3e-07 0.01 0.04 0.03 0.03 3.6e-02 2.2e-05 1.2e-04 5.6e-04
5 Brain mRNA stability Calr4 0.04 0.03 2.9e-03 0.02 0.03 0.01 0.02 3.8e-03 1.9e-03 1.6e-02 4.4e-03
6 Liver alternative TSS XM_063288592.1 0.03 0.02 7.5e-03 0 0.01 0 0 8.5e-02 4.3e-02 2.4e-01 2.0e-01
7 PL alternative TSS XM_063288592.1 0.03 0.03 3.1e-04 0.03 0.03 0.03 0.03 3.6e-04 1.4e-04 2.9e-04 3.8e-04
8 IC gene expression Calr4 0.11 0.08 1.6e-04 0.07 0.08 0.07 0.07 6.0e-04 4.4e-04 7.0e-04 7.3e-04
9 NAcc alternative TSS XM_063288592.1 0.03 0.02 1.1e-05 0.04 0.04 0.04 0.04 3.5e-06 3.1e-06 3.5e-06 2.6e-06
10 PL alternative TSS XM_063288592.1 0.04 0.03 4.5e-05 0.04 0.04 0.04 0.04 6.4e-05 2.1e-05 2.2e-05 3.5e-05
11 NAcc gene expression Calr4 0.06 0.04 1.9e-10 0.07 0.07 0.07 0.07 1.6e-10 1.2e-10 5.4e-11 1.7e-10
12 NAcc alternative TSS XM_063288592.1 0.04 0.03 2.7e-06 0.03 0.04 0.04 0.04 8.8e-06 1.8e-06 3.2e-06 3.9e-06
13 Brain alternative TSS XM_063288592.1 0.03 0.02 1.8e-03 0.02 0.03 0.02 0.02 2.4e-03 1.6e-03 9.4e-03 3.5e-03
14 NAcc mRNA stability Calr4 0.01 0.01 6.4e-03 0.01 0.01 0.01 0.01 3.3e-03 8.2e-03 4.1e-03 4.4e-03
15 pVTA gene expression Calr4 0.07 0.1 1.0e-03 0.04 0.04 0.04 0.04 3.2e-04 5.1e-04 3.3e-04 3.5e-04
16 Liver alternative TSS XM_063288592.1 0.04 0.03 6.9e-04 0.01 0.01 0.01 0.01 1.2e-02 3.1e-02 1.5e-02 4.0e-02
17 Brain alternative TSS XM_063288592.1 0.03 0.02 2.2e-03 0.02 0.03 0.02 0.02 6.4e-03 1.9e-03 6.6e-03 7.8e-03
18 Brain isoform ratio XM_063288592.1 0.04 0.03 9.5e-05 0.04 0.04 0.03 0.04 7.9e-05 6.1e-05 6.7e-04 1.3e-04
19 BLA gene expression Calr4 0.11 0.08 1.0e-04 0.05 0.06 0.05 0.06 8.1e-04 3.0e-04 1.9e-03 3.2e-04
20 NAcc isoform ratio XM_063288593.1 0.03 0.02 2.8e-05 0.02 0.02 0.02 0.03 1.5e-04 1.3e-04 2.5e-04 8.7e-05
21 PL gene expression Calr4 0.02 0.02 4.8e-03 0.02 0.01 0.02 0.02 2.9e-03 1.0e-02 6.2e-03 4.3e-03
22 PL mRNA stability Calr4 0.05 0.04 4.7e-04 0.03 0.01 0.01 0.02 4.2e-04 2.2e-02 7.6e-03 1.8e-03
23 BLA alternative TSS XM_063288592.1 0.05 0.04 9.3e-03 0.03 0.03 0.04 0.03 9.6e-03 6.9e-03 5.9e-03 7.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Bone: apparent density0.61.01.5-0.20.40.40.6-0.81.11.1-1.11.21.1-1.21.11.1-1.1-1.11.01.11.1-0.9-1.0-1.0-1.01.2
Area under the delay curve0.10.10.7-0.80.70.70.7-0.50.10.1-0.10.00.0-0.10.0-0.00.10.10.1-0.1-0.20.5-0.1-0.1-0.1-0.1
BMI with tail1.44.96.81.9-2.1-2.1-2.32.6-2.5-2.42.4-2.1-2.32.2-2.3-2.32.12.1-2.4-2.2-2.01.22.32.32.3-1.9
BMI without tail0.72.32.91.0-1.2-1.2-1.41.7-1.7-1.71.7-1.5-1.61.6-1.6-1.61.51.5-1.6-1.6-1.51.01.61.61.6-1.5
Body weight0.83.34.51.5-1.7-1.7-1.92.1-2.1-2.02.0-1.9-1.91.9-2.0-1.91.81.8-2.1-1.8-1.71.11.81.71.7-1.4
Weight adjusted by age0.30.51.41.1-1.2-1.2-1.21.1-0.7-0.70.7-0.4-0.60.5-0.6-0.50.40.4-0.6-0.5-0.4-0.10.70.70.7-0.4
Bone surface0.20.40.5-0.50.60.60.7-0.70.70.6-0.60.60.6-0.70.60.6-0.5-0.50.70.60.5-0.2-0.6-0.6-0.60.6
Bone volume0.00.00.1-0.10.10.10.2-0.20.20.2-0.20.30.2-0.30.20.2-0.2-0.20.20.20.2-0.1-0.1-0.1-0.10.2
Breakpoint value in progressive ratio session0.00.00.10.2-0.1-0.1-0.10.00.10.1-0.10.20.1-0.20.10.1-0.2-0.20.10.20.2-0.2-0.1-0.1-0.10.2
Number of licking bursts0.10.20.70.9-0.8-0.8-0.80.7-0.4-0.40.3-0.2-0.30.2-0.3-0.30.20.2-0.5-0.2-0.1-0.20.30.30.3-0.1
Context. condit. distance diff. score0.40.51.4-0.1-0.1-0.10.1-0.30.70.7-0.70.70.8-0.70.70.8-0.8-0.80.80.80.8-0.9-0.7-0.8-0.81.2
Locomotion velocity, session 13.23.45.0-0.00.30.30.6-1.32.02.0-2.02.12.1-2.12.12.1-2.2-2.21.92.12.2-2.1-1.8-2.0-2.02.2
Locomotion distance, session 10.10.10.40.4-0.3-0.3-0.30.10.20.3-0.30.30.3-0.20.30.3-0.4-0.40.20.40.4-0.5-0.2-0.4-0.40.6
Locomotion velocity, session 23.03.56.40.10.20.20.5-1.21.92.0-2.02.22.1-2.12.02.1-2.2-2.21.82.12.2-2.2-1.9-2.0-2.02.5
Locomotion distance, session 20.60.81.7-0.40.30.30.10.4-0.9-0.90.9-1.1-1.01.0-1.0-1.01.31.3-0.7-1.1-1.11.30.70.50.5-0.9
Locomotion velocity, session 30.80.91.4-0.40.50.50.6-0.91.01.0-1.00.91.0-1.01.01.0-0.9-0.91.11.01.0-0.8-1.0-1.1-1.11.2
Locomotion distance, session 30.20.20.6-0.70.60.60.5-0.2-0.2-0.30.3-0.5-0.30.5-0.3-0.40.60.6-0.1-0.4-0.50.80.10.10.1-0.5
Stereotopy head waving bouts, day 30.10.10.50.7-0.4-0.4-0.30.00.20.3-0.30.40.3-0.40.30.4-0.3-0.3-0.00.40.4-0.60.10.10.10.3
Stereotopy head waving duration, day 30.70.82.31.2-0.9-0.8-0.60.00.70.8-0.81.00.9-0.90.81.0-1.0-1.00.31.01.2-1.5-0.3-0.4-0.41.2
Locomotion velocity, session 70.40.42.5-1.61.21.21.2-0.80.30.2-0.2-0.10.1-0.10.20.10.30.30.70.0-0.10.6-0.5-0.7-0.70.0
Locomotion distance, session 70.91.15.5-2.32.01.91.8-1.10.0-0.10.2-0.6-0.30.4-0.3-0.40.90.90.5-0.6-0.81.6-0.4-0.4-0.4-0.7
Stereotopy head waving bouts, day 71.72.03.00.10.30.30.6-1.11.61.6-1.61.61.7-1.71.71.7-1.5-1.51.31.71.7-1.6-1.2-1.2-1.21.6
Stereotopy head waving duration, day 71.72.13.30.20.10.20.4-1.01.61.6-1.61.71.7-1.71.71.7-1.6-1.61.31.81.8-1.8-1.3-1.3-1.31.7
Locomotion velocity, session 82.12.54.0-0.90.90.91.1-1.41.71.7-1.71.61.7-1.71.71.7-1.5-1.51.71.71.6-1.3-1.7-1.9-1.92.0
Locomotion distance, session 80.10.10.4-0.50.30.30.3-0.20.20.2-0.20.00.2-0.10.20.20.00.00.40.20.10.0-0.4-0.6-0.60.6
Degree of sensitization distance0.20.20.6-0.80.50.40.3-0.0-0.3-0.40.4-0.5-0.50.4-0.4-0.50.50.5-0.1-0.5-0.60.80.20.10.1-0.6
Degree of sensitization stereotypy0.80.91.3-0.10.30.30.4-0.81.01.1-1.11.11.1-1.11.11.1-1.0-1.01.01.11.1-1.0-0.9-0.9-0.91.0
Conditioned locomotion0.30.31.41.1-1.2-1.2-1.10.8-0.2-0.10.10.2-0.1-0.1-0.10.0-0.2-0.2-0.40.10.2-0.70.30.30.30.3
Cocaine response after cond. corrected1.92.33.9-0.10.10.0-0.20.9-1.6-1.71.7-1.9-1.71.8-1.7-1.82.02.0-1.5-1.8-1.92.01.31.31.3-1.6
Cocaine response after cond. not corrected2.32.74.10.3-0.4-0.4-0.71.3-1.8-1.81.8-1.9-1.91.9-1.9-1.92.02.0-1.8-1.9-1.91.81.61.61.6-1.7
Cocaine response before conditioning0.10.10.60.7-0.7-0.7-0.70.5-0.2-0.10.10.1-0.1-0.0-0.1-0.0-0.1-0.1-0.30.00.1-0.40.40.50.5-0.0
Saline control response0.60.83.3-1.81.61.61.4-0.8-0.1-0.20.2-0.6-0.40.4-0.3-0.50.90.90.1-0.6-0.81.5-0.2-0.3-0.3-0.5
Bone: connectivity density1.11.72.3-0.91.11.11.3-1.41.41.4-1.41.31.3-1.41.31.3-1.1-1.11.41.21.2-0.7-1.4-1.5-1.51.4
Bone: cortical apparent density1.82.54.0-0.20.40.40.6-1.21.71.8-1.82.01.8-2.01.81.8-1.9-1.91.61.91.9-1.8-1.6-1.3-1.31.7
Bone: cortical area1.11.72.30.2-0.4-0.4-0.61.1-1.4-1.51.5-1.5-1.51.5-1.5-1.51.51.5-1.4-1.5-1.51.41.31.11.1-1.2
Bone: cortical porosity0.70.82.71.6-1.5-1.5-1.30.60.20.4-0.40.80.5-0.70.50.6-1.0-1.0-0.10.70.9-1.5-0.00.10.10.7
Bone: cortical porosity0.90.92.71.3-1.1-1.1-0.90.20.60.7-0.81.20.9-1.00.81.0-1.3-1.30.31.01.2-1.7-0.5-0.4-0.41.1
Bone: cortical thickness2.43.94.91.0-1.4-1.4-1.62.1-2.2-2.22.2-2.1-2.22.1-2.2-2.12.02.0-2.2-2.1-2.01.52.22.12.1-1.8
Bone: cortical thickness2.02.33.81.3-1.5-1.5-1.71.8-1.6-1.61.6-1.3-1.51.4-1.5-1.51.21.2-1.7-1.4-1.30.71.81.91.9-1.5
Bone: cortical tissue density2.12.84.5-0.10.30.30.6-1.31.81.9-1.92.11.9-2.11.92.0-2.0-2.01.72.02.0-1.9-1.6-1.4-1.41.8
Condit. Reinf. active minus inactive responses0.50.50.80.4-0.3-0.4-0.40.6-0.7-0.70.7-0.8-0.80.7-0.7-0.70.80.8-0.8-0.7-0.70.60.80.90.9-0.8
Condit. Reinf. active-inactive response ratio0.70.81.20.4-0.5-0.5-0.60.8-1.0-1.01.0-1.0-1.01.0-1.0-1.00.90.9-0.9-1.0-0.90.70.91.11.1-0.9
Condit. Reinf. active responses1.01.21.60.5-0.6-0.6-0.71.0-1.2-1.21.2-1.2-1.21.2-1.2-1.21.21.2-1.3-1.2-1.21.01.11.21.2-1.0
Condit. Reinf. inactive responses0.10.20.4-0.30.10.10.00.2-0.4-0.50.5-0.5-0.50.4-0.5-0.50.40.4-0.2-0.5-0.60.60.20.10.1-0.3
Incentive salience index mean1.51.92.40.8-0.9-0.9-1.01.4-1.5-1.51.5-1.5-1.51.5-1.5-1.51.51.5-1.6-1.5-1.41.11.51.61.6-1.2
Condit. Reinf. lever presses1.62.22.80.8-1.0-1.0-1.21.5-1.7-1.71.7-1.6-1.61.6-1.7-1.61.61.6-1.7-1.6-1.61.21.61.51.5-1.1
Condit. Reinf. active minus inactive responses0.60.72.0-1.20.80.80.6-0.1-0.6-0.70.7-0.8-0.80.7-0.8-0.91.11.1-0.4-0.9-1.11.40.60.60.6-1.3
Condit. Reinf. active-inactive response ratio0.20.31.0-1.00.80.80.6-0.3-0.2-0.30.3-0.4-0.40.3-0.3-0.40.50.5-0.0-0.4-0.60.90.10.10.1-0.7
Condit. Reinf. active responses0.30.51.1-0.50.20.20.10.2-0.6-0.70.7-0.7-0.70.6-0.7-0.80.80.8-0.5-0.8-0.80.90.70.70.7-1.0
Condit. Reinf. inactive responses0.30.40.80.6-0.7-0.7-0.70.8-0.7-0.70.7-0.5-0.60.5-0.6-0.60.50.5-0.7-0.6-0.50.30.90.90.9-0.6
Condit. Reinf. lever presses0.40.62.6-1.61.61.61.5-1.00.30.2-0.2-0.00.1-0.10.1-0.00.30.30.6-0.1-0.30.9-0.5-0.5-0.5-0.4
Condit. Reinf. lever reinforcers received0.30.41.1-0.70.50.50.30.1-0.5-0.60.6-0.7-0.70.6-0.6-0.70.80.8-0.3-0.8-0.81.00.50.50.5-1.0
Conditioned reinforcement - actives2.03.46.0-0.70.30.3-0.10.9-1.8-1.92.0-2.1-2.12.1-2.0-2.12.22.2-1.7-2.2-2.32.41.81.81.8-2.2
Conditioned reinforcement - inactives0.00.10.10.1-0.2-0.2-0.20.3-0.3-0.30.3-0.3-0.30.3-0.3-0.30.30.3-0.3-0.3-0.30.20.20.20.2-0.2
Conditioned locomotion0.91.11.7-0.20.0-0.0-0.20.6-1.1-1.11.1-1.3-1.21.2-1.2-1.21.31.3-1.0-1.2-1.31.31.01.01.0-1.2
Patch foraging indifference point 0 sec0.30.50.80.2-0.3-0.3-0.40.6-0.8-0.80.8-0.8-0.80.7-0.8-0.80.90.9-0.8-0.8-0.80.70.70.70.7-0.7
Patch foraging indifference point AUC0.20.30.3-0.30.40.40.4-0.50.60.6-0.60.50.6-0.60.60.6-0.5-0.50.60.50.5-0.4-0.6-0.6-0.60.6
Delay disc. indifference point, 0s delay0.50.51.7-1.31.21.21.2-1.00.60.5-0.50.40.4-0.40.40.4-0.3-0.30.50.30.20.3-0.4-0.8-0.80.5
Delay disc. indifference point, 16s delay1.01.11.50.2-0.4-0.4-0.50.9-1.2-1.21.2-1.2-1.21.1-1.2-1.21.21.2-1.1-1.2-1.21.11.11.11.1-1.2
Delay disc. indifference point, 2s delay0.10.10.3-0.50.40.40.4-0.40.30.2-0.20.30.2-0.30.20.2-0.3-0.30.30.20.10.0-0.3-0.3-0.30.2
Delay disc. indifference point, 24s delay0.20.20.6-0.70.60.60.6-0.60.40.4-0.40.40.4-0.40.40.4-0.3-0.30.50.30.3-0.1-0.4-0.2-0.20.1
Delay disc. indifference point, 4s delay0.10.10.3-0.30.20.20.2-0.1-0.1-0.20.2-0.1-0.20.1-0.2-0.20.20.2-0.2-0.2-0.30.40.10.40.4-0.5
Delay disc. indifference point, 8s delay0.10.10.4-0.60.50.50.5-0.30.0-0.00.0-0.1-0.10.0-0.1-0.10.20.20.0-0.1-0.20.4-0.0-0.1-0.1-0.1
Indifference point function ln k0.30.60.70.4-0.4-0.5-0.60.8-0.9-0.90.9-0.8-0.80.8-0.9-0.80.80.8-0.8-0.8-0.80.70.80.70.7-0.7
Indifference point function log k0.30.60.70.4-0.4-0.5-0.60.8-0.9-0.90.9-0.8-0.80.8-0.9-0.80.80.8-0.8-0.8-0.80.70.80.70.7-0.7
Patch foraging total patch changes 0 sec0.20.40.60.3-0.3-0.4-0.40.6-0.7-0.70.7-0.7-0.70.6-0.7-0.70.80.8-0.7-0.7-0.70.60.70.70.7-0.6
Patch foraging total patch changes 12 sec0.91.21.5-0.60.70.70.9-1.11.21.2-1.21.21.2-1.21.21.2-1.1-1.11.21.21.1-0.8-1.1-1.1-1.11.1
Patch foraging total patch changes 18 sec0.20.30.40.2-0.2-0.3-0.30.5-0.6-0.60.6-0.6-0.60.6-0.6-0.60.60.6-0.6-0.6-0.50.40.50.60.6-0.6
Patch foraging total patch changes 24 sec0.61.11.40.8-0.9-0.9-1.01.2-1.2-1.11.1-1.0-1.11.0-1.1-1.11.01.0-1.2-1.0-1.00.61.11.11.1-0.9
Patch foraging total patch changes 6 sec0.10.20.7-0.60.60.60.5-0.1-0.3-0.30.3-0.5-0.40.4-0.4-0.40.70.7-0.2-0.5-0.60.80.20.20.2-0.5
Patch foraging time to switch 0 sec0.91.82.5-0.10.40.40.6-1.11.51.5-1.51.51.5-1.51.51.5-1.5-1.51.31.61.6-1.4-1.4-1.4-1.41.5
Patch foraging water rate 0 sec1.32.83.51.1-1.3-1.3-1.51.8-1.9-1.91.9-1.7-1.81.7-1.8-1.81.71.7-1.8-1.8-1.71.21.91.91.9-1.6
Patch foraging water rate 12 sec1.63.44.40.7-0.9-0.9-1.11.7-2.0-2.12.1-2.1-2.12.1-2.1-2.12.12.1-2.0-2.1-2.01.71.81.81.8-1.8
Patch foraging water rate 18 sec0.10.10.30.5-0.5-0.5-0.40.20.00.0-0.10.30.1-0.20.10.1-0.3-0.30.00.20.2-0.40.30.30.30.0
Patch foraging water rate 24 sec0.10.10.40.7-0.6-0.6-0.60.4-0.2-0.10.10.1-0.1-0.1-0.1-0.0-0.1-0.1-0.20.00.1-0.30.20.10.10.2
Patch foraging water rate 6 sec1.11.62.30.7-0.9-1.0-1.11.4-1.4-1.41.4-1.2-1.41.3-1.4-1.31.31.3-1.4-1.3-1.30.91.51.41.4-1.2
Seeking ratio, delayed vs. immediate footshock2.32.84.00.5-0.7-0.7-0.91.5-1.9-1.91.9-2.0-1.92.0-1.9-1.92.02.0-1.9-1.9-1.91.71.61.41.4-1.3
Distance traveled before self-admin0.20.20.70.8-0.8-0.8-0.80.7-0.5-0.40.4-0.2-0.40.3-0.4-0.30.00.0-0.4-0.3-0.2-0.10.50.40.4-0.1
Distance traveled after self-admin0.91.11.60.9-1.0-1.0-1.11.3-1.2-1.21.2-0.9-1.11.0-1.1-1.10.80.8-1.1-1.0-1.00.61.21.11.1-0.9
Extensor digitorum longus weight1.24.68.21.9-2.2-2.2-2.42.5-2.3-2.22.2-1.8-2.11.9-2.1-2.01.71.7-2.3-1.9-1.70.82.62.92.9-2.2
Bone: elastic displacement0.30.31.61.3-1.2-1.1-1.10.7-0.2-0.10.10.10.0-0.0-0.00.1-0.3-0.3-0.30.10.3-0.80.30.40.40.3
Bone: elastic work0.10.10.30.5-0.5-0.5-0.50.5-0.4-0.40.4-0.3-0.30.4-0.4-0.30.20.2-0.4-0.3-0.20.00.40.40.4-0.2
Bone: endosteal estimation0.10.10.3-0.20.40.40.4-0.40.40.4-0.40.30.3-0.30.30.3-0.4-0.40.30.30.3-0.1-0.4-0.6-0.60.4
Bone: endosteal perimeter0.20.51.7-1.11.31.31.2-1.00.60.5-0.50.30.5-0.40.50.4-0.2-0.20.70.30.20.3-0.8-0.9-0.90.3
Epididymis fat weight0.10.31.0-1.01.01.00.9-0.80.50.4-0.40.20.3-0.20.30.3-0.2-0.20.50.20.10.2-0.5-0.6-0.60.2
Delta time in closed arm before/after self-admin0.00.00.1-0.20.20.20.2-0.1-0.0-0.00.0-0.1-0.00.0-0.0-0.10.20.2-0.0-0.1-0.10.2-0.0-0.0-0.0-0.1
Delta time in open arm before/after self-admin0.10.10.20.0-0.0-0.0-0.10.2-0.4-0.40.4-0.3-0.40.3-0.4-0.40.40.4-0.3-0.4-0.40.40.30.40.4-0.4
Diff in mean of infusions in LGA sessions0.20.21.1-1.00.80.80.7-0.3-0.1-0.20.2-0.2-0.30.2-0.3-0.30.30.3-0.0-0.4-0.50.80.10.10.1-0.4
Delay discount exponential model param0.10.10.70.8-0.7-0.7-0.70.4-0.1-0.00.0-0.00.00.1-0.00.1-0.1-0.1-0.10.10.2-0.50.10.00.00.2
Extinction: sum of active levers before priming0.40.42.51.6-1.4-1.4-1.30.9-0.3-0.20.2-0.0-0.10.1-0.1-0.0-0.0-0.0-0.40.00.2-0.80.30.30.30.1
Active lever presses in extinction session 61.81.82.9-0.3-0.0-0.1-0.30.9-1.4-1.51.5-1.4-1.61.4-1.5-1.61.31.3-1.2-1.6-1.71.71.41.41.4-1.5
Bone: final force0.00.10.3-0.50.60.50.5-0.40.10.1-0.1-0.10.00.00.00.00.00.00.2-0.0-0.10.3-0.2-0.3-0.30.0
Bone: final moment0.00.10.3-0.50.50.50.5-0.2-0.1-0.10.1-0.3-0.10.2-0.1-0.20.20.2-0.0-0.2-0.30.5-0.0-0.1-0.1-0.2
Food consumed during 24 hour testing period1.01.44.3-1.81.51.51.2-0.4-0.7-0.90.9-1.3-1.01.1-1.0-1.11.41.4-0.3-1.2-1.52.10.70.60.6-1.5
Glucose0.20.30.8-0.50.40.40.30.0-0.5-0.50.5-0.7-0.60.6-0.5-0.60.70.7-0.3-0.6-0.70.90.30.40.4-0.7
Heart weight1.52.34.31.9-2.0-2.0-2.12.0-1.6-1.51.4-1.1-1.41.2-1.4-1.21.01.0-1.7-1.2-1.00.21.71.71.7-1.1
Delay discount hyperbolic model param0.10.10.60.8-0.7-0.7-0.60.5-0.2-0.10.1-0.1-0.10.2-0.1-0.0-0.0-0.0-0.20.00.1-0.40.20.10.10.1
Intermittent access intake day 1-15 change0.40.81.3-0.20.10.1-0.10.5-0.9-0.90.9-1.1-1.01.0-1.0-1.01.11.1-0.9-1.0-1.11.10.70.70.7-1.0
Intermittent access intake escalation0.30.71.10.1-0.2-0.3-0.40.7-0.9-0.90.9-1.0-1.01.0-1.0-1.01.11.1-0.9-1.0-1.00.90.80.70.7-0.9
Intermittent access intake escalation 20.10.20.40.0-0.0-0.0-0.10.3-0.4-0.40.4-0.5-0.50.5-0.5-0.50.60.6-0.5-0.5-0.50.50.30.30.3-0.4
Intermitt. access day 1 inactive lever presses0.52.02.80.2-0.5-0.5-0.71.2-1.5-1.51.5-1.6-1.61.6-1.5-1.61.51.5-1.4-1.6-1.61.41.61.61.6-1.7
Intermitt. access day 15 inactive lever presses0.40.91.30.9-1.0-1.0-1.11.2-1.0-1.01.0-0.8-0.90.9-0.9-0.90.70.7-1.0-0.9-0.80.41.01.01.0-0.8
Intermitt. access escalation Index0.10.10.40.6-0.6-0.6-0.50.20.10.2-0.20.30.2-0.20.20.3-0.5-0.50.10.30.4-0.70.00.00.00.2
Intermittent access day 1 total infusions0.10.10.40.6-0.5-0.5-0.50.20.10.2-0.20.30.3-0.30.20.3-0.4-0.40.10.30.4-0.6-0.0-0.0-0.00.3
Intermittent access day 15 total infusions0.30.40.60.7-0.7-0.8-0.80.8-0.7-0.60.6-0.6-0.60.6-0.6-0.60.50.5-0.6-0.5-0.50.20.70.70.7-0.5
Intermittent access terminal intake (last 3 days)0.00.10.20.4-0.4-0.4-0.40.3-0.2-0.20.2-0.2-0.20.2-0.2-0.20.20.2-0.2-0.1-0.1-0.00.30.30.3-0.1
Intermittent access total infusions0.10.10.40.6-0.6-0.6-0.50.3-0.00.0-0.00.10.1-0.10.00.1-0.1-0.1-0.10.10.2-0.40.10.10.10.2
Intermittent access day 1 locomotion0.00.00.20.4-0.4-0.4-0.40.20.00.1-0.10.20.1-0.10.10.1-0.2-0.20.00.10.2-0.40.10.10.10.1
Intermittent access day 15 total locomotion0.20.30.7-0.40.30.30.20.1-0.5-0.50.5-0.6-0.60.6-0.6-0.60.70.7-0.4-0.6-0.70.80.50.50.5-0.6
Intermittent access total locomotion0.10.10.40.6-0.6-0.6-0.60.4-0.2-0.10.1-0.0-0.10.1-0.1-0.00.00.0-0.2-0.00.0-0.30.20.20.20.0
Intermittent access standard deviation1.42.93.90.6-0.8-0.8-1.01.5-1.9-1.91.9-1.9-1.91.9-1.9-1.92.02.0-1.8-1.9-1.91.61.71.71.7-1.8
Left kidney weight5.023.429.02.2-2.8-2.9-3.54.7-5.4-5.45.4-5.3-5.45.4-5.4-5.35.15.1-5.2-5.3-5.14.15.15.05.0-5.0
Right kidney weight2.913.416.82.1-2.5-2.6-3.03.8-4.1-4.14.1-4.0-4.04.1-4.0-4.03.93.9-4.1-3.9-3.72.83.93.73.7-3.3
Cocaine induced anxiety0.60.92.71.5-1.6-1.6-1.61.4-0.9-0.80.8-0.6-0.70.7-0.8-0.70.40.4-0.6-0.6-0.4-0.20.90.90.9-0.7
Post-drug Anxiety1.51.64.72.1-2.2-2.2-2.11.9-1.2-1.11.1-0.7-1.00.8-1.0-0.80.50.5-0.8-0.7-0.5-0.31.21.21.2-0.9
Baseline Anxiety0.10.20.30.2-0.2-0.2-0.30.4-0.4-0.40.4-0.4-0.40.4-0.4-0.40.40.4-0.4-0.4-0.40.30.50.50.5-0.5
Tail length0.00.00.20.1-0.0-0.0-0.0-0.00.10.1-0.10.00.1-0.10.10.1-0.1-0.10.10.10.1-0.1-0.2-0.3-0.30.4
Length with tail0.10.60.90.2-0.2-0.2-0.30.6-0.8-0.90.9-1.0-0.90.9-0.9-0.90.90.9-0.9-0.9-0.90.90.70.50.5-0.5
Length without tail1.34.16.00.3-0.5-0.6-0.91.6-2.2-2.32.3-2.4-2.32.3-2.3-2.32.52.5-2.2-2.4-2.42.22.01.71.7-1.9
Times rat made contact with spout0.91.02.9-1.11.11.10.8-0.2-0.7-0.80.8-1.1-0.90.9-0.9-1.01.31.3-0.5-1.1-1.31.70.50.50.5-1.3
Lifetime Intake0.00.00.00.1-0.1-0.1-0.10.00.00.0-0.00.10.0-0.10.00.0-0.1-0.10.00.10.1-0.10.00.00.00.1
Liver weight, left0.10.20.9-1.00.90.90.8-0.70.30.3-0.20.00.2-0.10.20.1-0.0-0.00.50.10.00.3-0.3-0.2-0.2-0.2
Liver weight, right0.20.31.0-1.01.01.00.9-0.80.40.4-0.40.20.3-0.20.30.3-0.2-0.20.60.20.10.3-0.6-0.7-0.70.2
Locomotor activity0.40.62.1-1.51.41.31.2-0.6-0.2-0.30.3-0.6-0.40.4-0.4-0.50.80.8-0.0-0.6-0.81.3-0.1-0.0-0.0-0.7
Locomotor testing distance0.50.93.0-1.31.21.21.0-0.3-0.6-0.70.8-1.1-0.90.9-0.8-1.01.31.3-0.5-1.1-1.21.70.20.20.2-1.0
Locomotor testing rearing0.61.13.6-1.91.71.71.5-0.7-0.4-0.50.6-0.9-0.70.8-0.7-0.81.21.2-0.2-1.0-1.21.90.1-0.0-0.0-0.9
Locomotion in novel chamber3.03.95.8-0.1-0.1-0.2-0.51.3-2.1-2.22.2-2.3-2.22.3-2.2-2.32.32.3-2.0-2.4-2.42.41.91.91.9-2.2
Locomotion in novel chamber post-restriction0.30.63.11.7-1.5-1.5-1.41.1-0.5-0.40.4-0.3-0.30.4-0.3-0.20.10.1-0.6-0.10.0-0.60.40.40.40.0
Fecal boli incidents, locomotor time 10.20.21.0-1.00.80.80.7-0.4-0.1-0.20.2-0.4-0.30.4-0.3-0.30.40.4-0.2-0.4-0.50.80.1-0.1-0.1-0.1
Change in fecal boli incidents, locomotor task0.40.40.7-0.60.60.60.6-0.70.70.6-0.60.70.6-0.70.60.6-0.6-0.60.70.60.5-0.3-0.8-0.9-0.90.8
Time >=10cm from walls, locomotor time 11.31.42.80.9-0.5-0.4-0.2-0.41.11.2-1.21.31.3-1.41.21.3-1.2-1.21.01.41.5-1.7-1.1-1.2-1.21.6
Bouts of movement, locomotor time 10.70.81.3-0.81.01.01.1-1.21.01.0-1.00.90.9-0.91.00.9-0.9-0.91.00.90.8-0.4-0.9-0.8-0.80.6
Total resting periods, locomotor time 10.50.50.7-0.50.60.70.7-0.80.80.8-0.80.80.8-0.80.80.8-0.8-0.80.80.70.7-0.5-0.7-0.6-0.60.5
Rest time, locomotor task time 10.10.20.8-0.90.80.80.8-0.60.30.3-0.30.10.2-0.20.20.2-0.1-0.10.30.10.10.3-0.4-0.3-0.30.0
Distance moved, locomotor task time 10.30.41.21.1-0.9-0.9-0.70.30.30.4-0.40.60.5-0.60.40.5-0.6-0.60.20.60.7-1.1-0.1-0.3-0.30.7
Vertical activity count, locomotor time 10.10.30.50.5-0.6-0.6-0.60.7-0.7-0.60.6-0.6-0.60.5-0.6-0.60.60.6-0.7-0.6-0.50.30.60.50.5-0.4
Time >=10cm from walls, locomotor time 20.10.10.40.7-0.7-0.7-0.60.4-0.10.0-0.00.10.1-0.10.00.1-0.1-0.10.00.10.2-0.50.1-0.2-0.20.5
Bouts of movement, locomotor time 20.30.51.50.7-0.4-0.4-0.2-0.30.70.8-0.80.90.8-0.80.90.9-0.9-0.90.70.91.0-1.2-0.5-0.1-0.10.4
Total resting periods, locomotor time 20.30.51.20.6-0.3-0.2-0.1-0.30.70.8-0.80.80.8-0.80.80.9-0.9-0.90.70.90.9-1.1-0.5-0.0-0.00.3
Rest time, locomotor task time 20.20.20.7-0.80.80.80.8-0.70.40.4-0.40.30.3-0.40.40.3-0.2-0.20.40.20.20.2-0.3-0.1-0.1-0.1
Distance moved, locomotor task time 20.70.81.61.1-1.2-1.2-1.31.3-1.0-0.90.9-0.9-0.91.0-0.9-0.80.60.6-0.9-0.8-0.60.10.90.70.7-0.5
Vertical activity count, locomotor time 21.41.93.00.5-0.7-0.7-0.91.3-1.5-1.51.5-1.7-1.51.7-1.5-1.51.61.6-1.5-1.5-1.51.21.31.31.3-1.3
Light reinforcement 10.10.31.11.0-1.0-1.0-1.00.8-0.4-0.40.4-0.3-0.30.3-0.3-0.30.20.2-0.6-0.2-0.1-0.30.50.40.4-0.0
Light reinforcement 21.11.72.51.2-1.3-1.3-1.41.6-1.4-1.41.4-1.3-1.31.4-1.3-1.31.11.1-1.5-1.2-1.10.61.51.31.3-1.0
Bone: marrow area0.00.10.2-0.10.30.30.3-0.30.30.3-0.30.30.3-0.30.30.2-0.3-0.30.20.20.2-0.1-0.3-0.5-0.50.3
Bone: maximum diameter0.10.20.30.6-0.5-0.5-0.50.6-0.5-0.40.4-0.3-0.40.4-0.4-0.40.30.3-0.6-0.4-0.30.10.40.30.3-0.1
Bone: maximum force0.00.00.2-0.40.40.40.4-0.2-0.0-0.00.0-0.1-0.10.1-0.1-0.10.10.1-0.0-0.1-0.20.4-0.0-0.1-0.1-0.1
Bone: maximum moment0.00.10.3-0.40.40.40.3-0.1-0.2-0.20.2-0.3-0.20.3-0.2-0.30.30.3-0.2-0.3-0.30.50.10.10.1-0.3
Mean time between licks in bursts0.92.13.7-1.81.81.91.9-1.91.61.5-1.51.21.4-1.41.41.3-1.0-1.01.61.21.1-0.3-1.6-1.6-1.61.1
Mean num. licks in bursts0.40.71.9-0.90.80.80.6-0.1-0.6-0.70.7-1.0-0.80.9-0.8-0.91.01.0-0.4-0.9-1.01.40.60.60.6-1.1
Cd content in liver0.60.60.8-0.70.70.70.8-0.90.90.9-0.80.80.8-0.80.80.8-0.7-0.70.90.80.7-0.5-0.9-0.8-0.80.6
Co content in liver0.10.10.3-0.60.50.50.5-0.30.10.1-0.1-0.10.00.10.0-0.00.10.10.2-0.0-0.10.3-0.00.10.1-0.3
Cu content in liver0.80.94.1-2.02.02.01.8-1.30.50.3-0.3-0.00.2-0.20.20.10.40.40.7-0.0-0.31.1-0.7-0.6-0.6-0.3
Fe content in liver0.60.71.71.3-1.2-1.2-1.21.1-0.8-0.80.8-0.6-0.70.8-0.7-0.70.40.4-0.9-0.6-0.5-0.01.01.01.0-0.5
K content in liver1.00.94.2-2.12.02.01.9-1.30.50.3-0.3-0.10.2-0.10.20.10.40.40.7-0.0-0.31.1-0.7-0.7-0.7-0.2
Mg content in liver1.61.74.9-1.61.41.31.0-0.2-0.9-1.11.1-1.5-1.21.3-1.2-1.31.71.7-0.6-1.4-1.62.20.50.50.5-1.7
Mn content in liver0.20.30.4-0.20.20.20.3-0.50.60.6-0.60.60.6-0.60.60.6-0.6-0.60.50.60.6-0.5-0.6-0.5-0.50.4
Na content in liver0.50.51.0-0.91.01.01.0-1.00.80.7-0.70.50.6-0.60.70.6-0.4-0.40.80.60.5-0.1-0.8-0.7-0.70.6
Rb content in liver0.10.20.8-0.90.80.80.8-0.50.1-0.00.0-0.2-0.10.1-0.1-0.10.30.30.2-0.2-0.30.60.00.00.0-0.2
Se content in liver0.20.31.3-1.11.11.01.0-0.70.30.2-0.20.10.2-0.10.20.10.10.10.40.0-0.10.5-0.5-0.5-0.5-0.1
Sr content in liver0.00.00.00.2-0.2-0.2-0.10.10.00.0-0.00.10.0-0.10.00.1-0.1-0.1-0.00.10.1-0.20.0-0.0-0.00.2
Zn content in liver1.01.13.9-2.01.91.91.8-1.50.90.7-0.70.40.6-0.60.60.5-0.1-0.11.10.40.20.5-1.1-1.2-1.20.2
Bone: minimum diameter0.51.03.0-0.90.90.80.60.1-0.8-0.90.9-1.2-1.01.0-1.0-1.11.31.3-0.7-1.2-1.31.70.50.30.3-1.1
Time in familiar zone, hab. session 10.50.50.8-0.00.00.10.2-0.50.80.8-0.80.90.8-0.90.80.8-0.8-0.80.70.90.9-0.9-0.6-0.6-0.60.8
Time in novel zone, hab. session 10.10.10.5-0.60.70.70.6-0.40.1-0.00.0-0.1-0.10.1-0.0-0.10.20.20.1-0.1-0.20.5-0.3-0.1-0.1-0.2
Total zone transitions, hab. session 10.20.30.80.8-0.6-0.5-0.40.10.30.4-0.40.60.5-0.50.40.5-0.6-0.60.10.60.6-0.9-0.2-0.3-0.30.9
Total locomotion distance, hab. session 10.30.52.21.5-1.3-1.3-1.20.9-0.4-0.30.3-0.1-0.20.2-0.2-0.1-0.0-0.0-0.6-0.10.1-0.60.60.60.60.2
Locomotion velocity, hab. session 10.20.31.41.2-1.1-1.0-1.00.7-0.2-0.20.2-0.0-0.10.1-0.1-0.0-0.1-0.1-0.50.00.2-0.60.40.40.40.2
Time in familiar zone, hab. session 20.60.72.8-1.71.61.61.5-1.20.60.5-0.50.20.4-0.30.40.3-0.0-0.00.80.20.10.5-0.8-0.6-0.6-0.2
Time in novel zone, hab. session 20.20.21.31.1-1.0-1.0-0.90.6-0.2-0.10.10.0-0.00.1-0.10.0-0.2-0.2-0.40.10.2-0.60.30.30.30.3
Total zone transitions, hab. session 20.10.10.5-0.70.70.70.6-0.40.0-0.00.0-0.3-0.10.2-0.1-0.10.40.40.1-0.2-0.20.5-0.2-0.3-0.30.0
Total locomotion distance, hab. session 20.20.30.40.2-0.2-0.2-0.20.4-0.5-0.50.5-0.6-0.50.6-0.5-0.50.70.7-0.6-0.5-0.50.50.50.50.5-0.5
Locomotion velocity, hab. session 20.30.30.60.2-0.2-0.2-0.30.5-0.6-0.60.6-0.7-0.60.7-0.6-0.60.70.7-0.7-0.6-0.60.50.60.60.6-0.6
Novel to familiar place preference ratio1.51.73.1-0.30.20.2-0.10.7-1.3-1.41.4-1.5-1.51.5-1.5-1.51.61.6-1.2-1.6-1.61.81.11.11.1-1.6
Novelty place preference0.90.91.7-0.20.10.1-0.10.5-1.0-1.11.1-1.1-1.11.1-1.1-1.11.21.2-0.9-1.2-1.21.30.80.80.8-1.2
Time in novel zone, NPP test0.60.71.4-0.20.20.20.00.4-0.8-0.90.9-0.9-0.90.9-0.9-1.01.01.0-0.7-1.0-1.11.20.60.70.7-1.1
Total zone transitions, NPP test0.50.81.31.1-1.0-1.0-1.11.1-0.9-0.90.9-0.8-0.80.8-0.9-0.80.70.7-1.1-0.8-0.70.31.01.01.0-0.5
Total locomotion distance, NPP test0.81.01.61.0-1.0-1.0-1.11.1-1.1-1.01.0-1.0-1.01.0-1.0-1.00.90.9-1.2-0.9-0.80.51.21.31.3-0.9
Locomotion velocity, NPP test1.21.72.51.1-1.2-1.2-1.31.4-1.4-1.41.4-1.3-1.31.4-1.3-1.31.21.2-1.5-1.2-1.20.71.51.61.6-1.2
Intraocular pressure0.30.40.9-0.20.10.10.00.3-0.6-0.60.6-0.7-0.70.7-0.7-0.70.70.7-0.5-0.7-0.80.80.50.70.7-0.9
Delta distance traveled before/after self-admin1.31.32.00.2-0.4-0.4-0.50.9-1.2-1.21.3-1.3-1.31.3-1.3-1.31.41.4-1.2-1.3-1.31.21.21.31.3-1.4
Delta ambulatory time before/after self-admin0.80.91.30.1-0.3-0.3-0.40.8-1.0-1.11.1-1.1-1.11.1-1.1-1.11.11.1-1.0-1.1-1.11.01.01.01.0-1.1
Parametrial fat weight0.00.10.30.3-0.2-0.2-0.1-0.00.20.2-0.20.30.3-0.30.30.3-0.3-0.30.10.30.3-0.4-0.3-0.3-0.30.5
Pavlov. Cond. lever latency1.51.92.8-1.41.31.31.4-1.61.41.4-1.41.41.3-1.41.41.3-1.3-1.31.61.21.1-0.7-1.7-1.6-1.61.0
Pavlov. Cond. magazine entry latency0.20.30.4-0.30.50.50.6-0.60.60.6-0.60.50.6-0.50.60.5-0.4-0.40.60.50.5-0.3-0.6-0.5-0.50.5
Pavlov. Cond. change in total contacts0.00.00.00.1-0.1-0.1-0.10.1-0.1-0.10.1-0.1-0.10.1-0.1-0.10.10.1-0.2-0.1-0.10.10.10.10.10.1
Pavlov. Cond. index score0.30.30.50.5-0.5-0.5-0.50.6-0.6-0.60.6-0.7-0.60.6-0.6-0.60.60.6-0.7-0.6-0.50.40.70.70.7-0.4
Pavlov. Cond. latency score0.30.40.60.6-0.4-0.5-0.50.6-0.7-0.60.6-0.7-0.60.7-0.6-0.60.80.8-0.8-0.6-0.60.40.80.70.7-0.5
Pavlov. Cond. lever contacts1.11.42.01.2-1.2-1.2-1.31.4-1.2-1.21.2-1.1-1.11.2-1.1-1.11.11.1-1.4-1.0-0.90.51.41.41.4-0.7
Pavlov. Cond. magazine entry number0.20.30.30.1-0.3-0.3-0.40.5-0.6-0.60.6-0.5-0.60.5-0.6-0.60.50.5-0.5-0.6-0.50.40.60.50.5-0.6
Pavlov. Cond. intertrial magazine entries0.80.92.1-0.70.50.40.30.3-0.9-1.01.0-1.2-1.01.1-1.0-1.11.31.3-0.7-1.1-1.21.50.80.60.6-1.1
Pavlov. Cond. lever-magazine prob. diff.0.40.50.70.6-0.5-0.5-0.60.7-0.8-0.80.8-0.8-0.70.8-0.8-0.70.80.8-0.8-0.7-0.70.50.80.80.8-0.6
Pavlov. Cond. response bias0.10.10.40.6-0.5-0.5-0.50.4-0.3-0.20.2-0.2-0.20.2-0.2-0.20.20.2-0.4-0.1-0.1-0.10.30.40.40.1
Pavlov. Cond. lever latency0.71.04.12.0-1.9-1.9-1.70.90.10.3-0.30.70.4-0.40.40.6-0.9-0.9-0.20.70.9-1.70.20.20.21.0
Pavlov. Cond. magazine entry latency1.61.97.8-2.82.82.72.6-2.00.90.7-0.70.20.5-0.40.60.30.10.11.30.2-0.11.2-1.2-1.1-1.1-0.2
Pavlov. Cond. change in total contacts0.71.25.7-2.42.22.22.0-1.20.1-0.10.1-0.5-0.30.3-0.2-0.40.80.80.5-0.5-0.81.7-0.4-0.5-0.5-0.7
Pavlov. Cond. index score1.41.88.3-2.92.82.82.6-1.80.50.3-0.3-0.30.1-0.00.1-0.10.60.61.0-0.3-0.61.7-0.9-0.9-0.9-0.7
Pavlov. Cond. latency score1.31.77.7-2.82.72.72.5-1.70.50.2-0.2-0.30.00.00.1-0.10.60.60.9-0.3-0.61.7-0.8-0.8-0.8-0.7
Pavlov. Cond. lever contacts0.60.83.3-1.81.71.71.5-0.9-0.1-0.20.2-0.5-0.30.3-0.3-0.50.80.80.3-0.6-0.81.5-0.2-0.3-0.3-0.8
Pavlov. Cond. magazine entry number2.42.99.33.0-3.0-3.0-3.02.5-1.5-1.31.2-0.7-1.11.0-1.1-0.90.40.4-1.8-0.8-0.4-0.81.81.91.9-0.4
Pavlov. Cond. intertrial magazine entries0.30.51.71.3-1.3-1.3-1.10.60.10.2-0.20.60.3-0.50.30.4-0.7-0.7-0.10.50.7-1.20.20.30.30.4
Pavlov. Cond. lever-magazine prob. diff.1.52.09.3-3.13.02.92.7-1.90.50.3-0.3-0.30.10.00.1-0.10.60.61.0-0.3-0.61.8-0.9-0.9-0.9-0.7
Pavlov. Cond. response bias0.91.35.8-2.42.32.32.2-1.50.50.3-0.3-0.10.1-0.10.2-0.00.40.40.9-0.1-0.41.3-0.8-0.9-0.9-0.4
Time in closed arm before self-admin0.40.50.80.1-0.1-0.00.1-0.40.70.7-0.80.70.8-0.70.80.8-0.7-0.70.60.80.9-0.9-0.7-0.7-0.70.8
Time in closed arm after self-admin0.20.20.50.3-0.3-0.2-0.1-0.10.40.5-0.50.50.5-0.50.50.5-0.5-0.50.40.60.6-0.7-0.4-0.5-0.50.6
Time in open arm before self-admin0.20.21.0-1.00.90.80.7-0.4-0.1-0.20.2-0.2-0.20.2-0.2-0.30.20.20.0-0.3-0.50.80.10.00.0-0.3
Time in open arm after self-admin0.80.91.5-0.10.00.0-0.10.6-1.0-1.01.0-1.0-1.11.0-1.1-1.11.01.0-0.9-1.1-1.21.20.90.90.9-1.1
Bone: periosteal estimation0.20.50.70.4-0.3-0.3-0.40.7-0.8-0.80.8-0.8-0.80.8-0.8-0.80.70.7-0.9-0.8-0.80.70.70.50.5-0.5
Bone: periosteal perimeter0.10.10.4-0.30.30.30.20.0-0.3-0.30.3-0.4-0.40.4-0.4-0.40.40.4-0.3-0.4-0.50.60.10.00.0-0.3
Bone: post-yield work0.00.10.1-0.20.40.40.3-0.30.20.2-0.20.10.2-0.10.20.2-0.2-0.20.20.10.10.0-0.2-0.4-0.40.2
Progressive ratio test 1 active lever presses0.60.81.10.8-0.9-0.9-1.01.1-1.0-0.90.9-0.8-0.90.9-0.9-0.90.80.8-1.0-0.9-0.80.40.90.90.9-0.8
Progressive ratio test 1 breakpoint0.60.81.20.9-0.9-1.0-1.01.1-1.0-0.90.9-0.8-0.90.9-0.9-0.90.80.8-1.0-0.8-0.80.40.90.90.9-0.7
Progressive ratio test 1 inactive lever presses0.30.50.80.8-0.8-0.8-0.90.9-0.8-0.70.7-0.6-0.70.6-0.7-0.70.60.6-0.7-0.6-0.60.20.70.70.7-0.6
Progressive ratio test 2 active lever presses0.50.50.80.8-0.8-0.8-0.80.9-0.8-0.80.8-0.7-0.70.7-0.8-0.70.70.7-0.8-0.7-0.60.30.70.70.7-0.6
Progressive ratio test 2 breakpoint0.50.61.11.0-1.0-1.0-1.01.0-0.8-0.80.8-0.6-0.70.6-0.7-0.70.70.7-0.8-0.6-0.60.20.80.80.8-0.5
Progressive ratio test 2 inactive lever presses0.00.10.10.1-0.1-0.1-0.20.2-0.3-0.30.3-0.2-0.30.2-0.3-0.30.30.3-0.2-0.3-0.30.20.30.30.3-0.3
Incentive Sensitization - Responses0.00.00.00.1-0.1-0.1-0.10.1-0.1-0.00.0-0.0-0.00.0-0.0-0.00.10.1-0.1-0.0-0.0-0.00.00.00.00.0
Incentive Sensitization - Breakpoint0.00.00.00.1-0.1-0.1-0.10.1-0.1-0.10.1-0.1-0.10.1-0.1-0.10.20.2-0.2-0.1-0.10.10.10.10.1-0.1
Sum of active levers in priming session hrs 5-60.30.31.41.2-1.0-1.0-1.00.8-0.4-0.40.3-0.1-0.30.2-0.3-0.20.10.1-0.4-0.2-0.1-0.40.40.50.5-0.1
Progressive ratio0.20.30.50.1-0.1-0.1-0.20.4-0.6-0.60.6-0.7-0.60.7-0.6-0.70.60.6-0.6-0.7-0.70.60.50.40.4-0.5
Food seeking constrained by brief footshock2.73.34.2-0.70.90.91.1-1.62.02.0-2.02.02.0-1.92.02.0-2.0-2.01.92.02.0-1.7-1.9-2.0-2.02.1
Seeking ratio, punishment vs. effort2.63.74.8-0.60.80.91.1-1.72.12.2-2.22.22.2-2.22.22.2-2.1-2.12.12.22.2-1.9-2.0-1.9-1.92.0
Retroperitoneal fat weight0.10.30.5-0.00.20.20.2-0.40.60.6-0.60.60.6-0.60.60.6-0.6-0.60.50.60.6-0.5-0.6-0.7-0.70.7
Reaction time number correct0.20.31.11.0-1.0-1.0-0.90.50.00.1-0.10.50.2-0.40.20.3-0.5-0.5-0.00.40.5-0.90.30.30.30.3
Reaction time mean minus median0.51.25.7-2.42.22.22.0-1.40.30.1-0.1-0.4-0.10.2-0.0-0.20.60.60.5-0.4-0.61.5-0.3-0.2-0.2-1.0
Reaction time mean minus median AUC0.30.83.9-2.01.91.91.7-1.20.30.2-0.2-0.10.00.00.1-0.10.30.30.5-0.2-0.41.1-0.4-0.3-0.3-0.7
Reaction time num false alarms1.11.63.5-0.80.50.50.30.4-1.2-1.31.3-1.6-1.41.5-1.4-1.51.61.6-1.0-1.5-1.61.91.01.01.0-1.6
Reaction time num false alarms AUC1.82.85.4-0.70.40.40.10.7-1.6-1.81.8-2.1-1.92.0-1.8-1.92.12.1-1.4-2.0-2.12.31.51.41.4-2.1
Reaction time trials correct on left0.20.31.11.0-1.0-1.0-0.90.50.00.1-0.10.50.2-0.40.20.3-0.5-0.5-0.00.40.5-0.90.30.30.30.3
Reaction time trials on left0.10.20.80.9-0.9-0.9-0.80.40.00.1-0.10.40.2-0.30.20.3-0.5-0.5-0.00.30.4-0.80.30.30.30.2
Reaction time mean0.50.93.9-2.01.91.91.8-1.30.50.4-0.40.00.2-0.20.30.10.20.20.70.0-0.21.0-0.8-0.8-0.8-0.2
Reaction time mean AUC0.50.93.2-1.81.81.81.7-1.40.70.6-0.60.30.5-0.40.50.4-0.1-0.10.80.30.10.6-0.9-0.9-0.90.0
Median of all reaction times0.50.62.2-1.51.51.51.4-1.10.60.5-0.50.30.4-0.40.40.3-0.2-0.20.70.30.10.5-0.9-0.9-0.90.2
Reaction time omissions0.81.14.0-2.01.81.71.5-0.8-0.3-0.50.5-0.9-0.70.7-0.6-0.81.11.1-0.1-0.9-1.11.80.10.10.1-1.4
Reaction time false alarm rate2.13.06.7-1.10.80.70.40.6-1.6-1.81.8-2.2-1.92.0-1.9-2.02.22.2-1.4-2.1-2.22.61.21.21.2-2.1
Reaction time premature initiation rate0.20.31.2-1.11.01.01.0-0.80.30.3-0.30.10.2-0.20.20.10.10.10.40.1-0.00.4-0.3-0.3-0.3-0.1
Reaction time premature initiations0.10.20.3-0.50.50.50.5-0.50.50.4-0.40.40.4-0.50.40.4-0.3-0.30.50.40.3-0.1-0.3-0.3-0.30.2
Std. dev. reaction times0.71.25.8-2.42.22.22.0-1.30.1-0.10.1-0.5-0.30.4-0.2-0.40.80.80.3-0.5-0.81.7-0.3-0.2-0.2-1.0
Reaction time trials completed0.10.20.80.9-0.9-0.9-0.80.40.00.1-0.10.40.2-0.30.20.3-0.5-0.5-0.00.30.4-0.80.30.30.30.2
Reaction time trials AUC0.10.20.90.9-0.9-0.9-0.90.6-0.2-0.10.10.2-0.0-0.1-0.00.1-0.3-0.3-0.20.10.2-0.60.40.50.50.0
Run reversals in cocaine runway, females0.20.20.8-0.80.90.90.9-0.70.40.3-0.30.10.3-0.20.30.2-0.1-0.10.30.20.10.3-0.4-0.5-0.50.2
Run reversals in cocaine runway, males2.22.23.8-0.40.20.2-0.10.8-1.5-1.61.6-1.6-1.71.7-1.6-1.71.61.6-1.4-1.8-1.91.91.51.51.5-1.9
Latency to leave start box in cocaine runway1.01.12.21.5-1.4-1.4-1.41.4-1.1-1.01.0-0.9-1.00.9-1.0-0.90.80.8-1.1-0.8-0.70.21.21.21.2-0.9
Latency to leave start box in cocaine runway, F1.72.04.02.0-1.9-1.9-1.91.8-1.4-1.31.3-1.1-1.21.2-1.3-1.11.01.0-1.5-1.1-0.90.21.61.51.5-1.0
Latency to leave start box in cocaine runway, M0.20.20.9-1.00.90.90.8-0.60.30.2-0.20.10.1-0.10.20.1-0.0-0.00.20.1-0.00.4-0.2-0.1-0.1-0.1
Std. dev. time between licks in bursts2.12.93.8-1.51.61.61.7-1.91.91.8-1.81.71.8-1.81.81.7-1.5-1.51.91.61.5-0.9-1.9-1.9-1.91.5
Total sessions with >9 infusions0.00.10.3-0.50.50.50.5-0.30.10.1-0.00.00.0-0.00.0-0.0-0.1-0.10.1-0.0-0.10.3-0.1-0.1-0.1-0.0
Short access day 1 total inactive lever presses1.52.02.71.0-1.1-1.2-1.31.5-1.5-1.51.5-1.4-1.51.5-1.5-1.41.41.4-1.4-1.4-1.30.91.61.61.6-1.5
Short access day 10 total inactive lever presses0.10.20.30.1-0.2-0.2-0.30.4-0.5-0.50.5-0.5-0.50.5-0.5-0.50.50.5-0.5-0.5-0.50.50.50.50.5-0.6
Short access day 1 total infusions0.00.00.00.2-0.2-0.2-0.20.2-0.1-0.10.1-0.0-0.10.0-0.1-0.10.00.0-0.1-0.1-0.0-0.10.10.10.1-0.0
Short access day 10 total infusions0.20.31.41.2-1.1-1.1-1.10.8-0.4-0.30.3-0.1-0.20.2-0.3-0.20.00.0-0.4-0.10.0-0.50.30.30.3-0.0
Short access total infusions0.00.00.1-0.20.20.20.2-0.20.20.2-0.20.30.2-0.20.20.2-0.3-0.30.20.20.2-0.1-0.2-0.2-0.20.2
Short access day 1 locomotion1.01.21.9-0.20.00.0-0.20.7-1.1-1.21.2-1.3-1.21.3-1.2-1.31.31.3-1.1-1.3-1.41.41.11.11.1-1.3
Short access day 10 total locomotion0.40.70.90.5-0.6-0.6-0.70.9-0.9-0.90.9-0.9-0.90.9-0.9-0.90.80.8-0.9-0.9-0.80.60.70.70.7-0.8
Short access total locomotion0.00.00.10.0-0.0-0.00.0-0.10.20.2-0.20.20.2-0.20.20.2-0.3-0.30.20.20.2-0.2-0.2-0.2-0.20.2
One hour access (0.3 mA shock)0.10.10.2-0.40.40.40.4-0.40.30.3-0.30.30.3-0.30.30.3-0.1-0.10.30.30.2-0.0-0.3-0.3-0.30.3
Compulsive drug intake0.70.81.30.2-0.00.00.2-0.60.91.0-1.01.11.0-1.01.01.1-1.1-1.10.91.11.1-1.1-0.7-0.7-0.71.0
One hour access (shock baseline)0.81.21.80.2-0.3-0.4-0.50.9-1.2-1.21.2-1.3-1.31.2-1.3-1.31.31.3-1.2-1.3-1.31.21.01.01.0-1.2
Social response proportion0.20.20.6-0.70.70.70.7-0.60.40.4-0.40.30.3-0.40.30.3-0.2-0.20.50.20.20.1-0.6-0.5-0.50.2
Social responses1.11.52.1-1.21.31.31.4-1.51.31.3-1.31.21.2-1.31.21.2-1.0-1.01.31.11.0-0.5-1.4-1.4-1.41.0
Social time0.10.10.2-0.30.30.30.2-0.0-0.2-0.20.2-0.3-0.30.3-0.3-0.30.30.3-0.1-0.3-0.40.50.10.10.1-0.4
Soleus weight2.88.211.51.5-1.9-1.9-2.22.8-3.1-3.13.1-2.9-3.12.9-3.1-3.12.92.9-3.1-3.0-2.92.23.33.43.4-3.2
Bone: stiffness0.00.00.2-0.40.40.40.4-0.30.10.1-0.10.00.0-0.10.00.00.00.00.1-0.0-0.10.2-0.2-0.3-0.30.1
Tibialis anterior weight3.612.119.23.7-4.0-4.0-4.24.3-3.7-3.53.5-2.9-3.33.1-3.3-3.12.62.6-3.9-3.0-2.61.14.24.44.4-3.0
Time to tail flick, vehicle, before self-admin2.12.23.21.7-1.6-1.6-1.71.8-1.6-1.51.5-1.5-1.41.5-1.4-1.31.41.4-1.6-1.3-1.20.51.51.51.5-1.3
Time to tail flick, vehicle, after self-admin0.60.72.01.4-1.3-1.3-1.31.2-0.8-0.80.8-0.6-0.70.7-0.7-0.60.50.5-0.8-0.6-0.4-0.10.80.80.8-0.5
Time to tail flick, test, before self-admin3.43.510.23.2-3.0-3.0-3.02.7-1.8-1.61.6-1.2-1.41.4-1.5-1.31.01.0-1.8-1.1-0.8-0.41.81.81.8-1.0
Time to tail flick, test, after self-admin1.11.22.31.3-1.5-1.5-1.51.5-1.2-1.11.1-0.8-1.00.9-1.0-0.90.70.7-1.1-0.9-0.70.21.21.01.0-0.7
Delta time to tail flick, vehicle, before/after SA0.00.00.10.3-0.3-0.3-0.30.3-0.1-0.10.10.0-0.10.0-0.1-0.1-0.1-0.1-0.1-0.0-0.0-0.10.10.10.10.0
Delta time to tail flick, test, before/after SA0.40.42.4-1.61.31.31.3-0.90.40.3-0.30.20.2-0.20.20.1-0.1-0.10.40.0-0.10.6-0.4-0.5-0.50.1
Tibia length0.10.20.30.2-0.3-0.3-0.30.5-0.5-0.50.5-0.6-0.50.6-0.6-0.50.50.5-0.5-0.5-0.50.40.40.10.1-0.0
Ambulatory time before self-admin0.00.10.20.4-0.5-0.5-0.50.4-0.3-0.20.2-0.0-0.20.1-0.2-0.2-0.1-0.1-0.2-0.2-0.1-0.10.30.20.2-0.0
Ambulatory time after self-admin0.50.61.00.8-0.8-0.9-0.91.0-0.9-0.90.9-0.6-0.90.7-0.9-0.80.50.5-0.8-0.8-0.70.40.90.90.9-0.7
Bone: tissue strength0.80.81.8-1.21.31.31.4-1.30.90.9-0.90.60.8-0.70.80.7-0.5-0.51.00.70.5-0.0-1.1-0.9-0.90.4
Total heroin consumption0.30.30.6-0.40.40.40.4-0.50.60.6-0.60.80.6-0.70.60.6-0.8-0.80.70.60.5-0.4-0.6-0.6-0.60.7
Bone: trabecular number0.71.21.8-0.60.80.80.9-1.11.21.2-1.21.31.2-1.31.21.2-1.1-1.11.21.11.1-0.8-1.3-1.3-1.31.3
Bone: trabecular spacing1.11.52.21.1-1.3-1.3-1.41.5-1.3-1.31.3-1.2-1.21.3-1.3-1.21.01.0-1.4-1.2-1.00.61.41.41.4-1.0
Bone: trabecular thickness0.50.71.3-1.01.11.11.1-1.10.90.8-0.80.70.7-0.80.80.7-0.5-0.50.90.60.5-0.1-0.9-0.9-0.90.5
Bone: trabecular tissue density0.30.41.10.7-0.6-0.6-0.4-0.00.50.6-0.60.80.6-0.70.60.7-0.9-0.90.40.70.8-1.1-0.3-0.2-0.20.5
Water consumed over 24 hours1.11.53.5-0.90.70.60.40.3-1.1-1.21.2-1.4-1.31.3-1.3-1.41.61.6-0.9-1.4-1.61.90.90.80.8-1.6
Number of responses in last shaping day2.52.73.70.4-0.6-0.7-0.91.4-1.8-1.81.8-1.8-1.81.8-1.8-1.81.81.8-1.7-1.8-1.81.61.91.91.9-1.9