Hub : Genes

Cacna2d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC alternative TSS NM_001110847.1 0.21 0.12 4.9e-03 0.03 0.04 0.05 0.04 1.5e-02 7.4e-03 2.6e-03 1.4e-02
2 PL gene expression Cacna2d1 0.82 0.05 3.8e-05 0.03 0.03 0.03 0.03 1.4e-04 4.1e-04 3.7e-04 8.0e-04
3 LHb alternative TSS NM_001110847.1 0.15 0.1 6.6e-03 0.06 0.01 0 0.01 1.7e-02 2.2e-01 2.4e-01 1.6e-01
4 LHb alternative TSS NM_001110847.1 0.15 0.1 9.3e-03 0.05 0.01 -0 0.01 2.9e-02 2.2e-01 3.3e-01 1.7e-01
5 Liver gene expression Cacna2d1 0.16 0.1 5.0e-06 0.05 0.05 0.05 0.04 3.8e-06 1.5e-06 1.4e-06 2.4e-05
6 NAcc gene expression Cacna2d1 0.63 0.06 0.0e+00 0.23 0.28 0.25 0.24 3.7e-34 6.6e-42 5.7e-37 3.8e-36
7 NAcc intron excision ratio chr4_19948697_19950353 0.01 0.01 2.5e-03 0.02 0.01 0.02 0.02 4.2e-04 3.0e-03 9.1e-04 1.3e-03
8 IC gene expression Cacna2d1 0.06 0.04 6.1e-03 0.01 0.03 0.01 0.02 7.9e-02 1.4e-02 9.5e-02 7.1e-02
9 IL gene expression Cacna2d1 0.46 0.23 7.2e-06 0.19 0.22 0.14 0.18 2.6e-05 5.6e-06 2.5e-04 4.6e-05
10 Brain gene expression Cacna2d1 0.95 0 0.0e+00 0.34 0.31 0.32 0.32 2.1e-32 4.7e-29 3.4e-30 4.1e-30
11 IC intron excision ratio chr4_19948697_19950353 0.14 0.09 3.3e-03 0.03 0.06 0.05 0.05 2.6e-02 2.4e-03 3.6e-03 4.0e-03
12 Brain isoform ratio NM_012919.3 0.11 0.09 3.8e-06 0.06 0.06 0.04 0.06 3.2e-06 3.2e-06 5.9e-05 3.1e-06
13 Adipose alternative TSS XM_063285611.1 0.04 0.04 2.7e-03 0.02 0.01 0.01 0.02 1.9e-03 1.8e-02 2.2e-02 6.3e-03
14 Adipose isoform ratio XM_063285611.1 0.05 0.09 2.5e-03 0.02 0.01 0 0.01 3.7e-03 3.0e-02 9.6e-02 2.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.80.50.20.10.1-0.0-0.50.1-0.40.10.20.10.20.90.9
Area under the delay curve0.10.10.70.40.40.40.40.80.30.4-0.2-0.2-0.2-0.30.00.10.1
BMI with tail0.10.30.8-0.6-0.7-0.9-0.9-0.40.1-0.20.60.6-0.30.8-0.2-0.2-0.2
BMI without tail0.10.41.40.5-0.5-0.5-0.50.90.6-0.70.71.2-0.90.0-0.9-0.2-0.2
Body weight0.20.72.0-0.9-1.1-1.2-1.2-1.1-0.00.3-0.00.30.31.40.31.01.0
Weight adjusted by age0.10.30.70.30.70.80.80.30.4-0.10.1-0.4-0.1-0.7-0.0-0.8-0.8
Bone surface0.30.73.0-1.1-0.8-0.9-0.9-1.7-0.1-0.10.20.20.21.40.10.50.5
Bone volume0.20.41.6-0.5-0.2-0.3-0.3-1.2-0.60.5-0.4-0.40.60.70.60.80.8
Breakpoint value in progressive ratio session0.30.62.11.01.21.21.20.3-0.30.1-0.5-0.60.4-1.40.2-0.3-0.3
Number of licking bursts0.20.61.20.40.70.70.7-0.4-0.81.1-1.0-1.10.9-0.51.10.70.7
Context. condit. distance diff. score0.81.03.41.70.60.40.41.90.6-0.90.40.7-0.9-1.6-0.8-0.8-0.8
Locomotion velocity, session 11.72.04.70.41.71.61.6-0.9-1.51.7-1.5-2.21.6-1.11.50.40.4
Locomotion distance, session 14.45.611.0-0.32.22.22.2-2.3-2.93.1-2.6-3.32.9-0.43.01.51.5
Locomotion velocity, session 20.60.71.7-0.21.31.31.3-0.4-0.20.3-0.1-1.10.3-0.80.4-1.0-1.0
Locomotion distance, session 21.52.04.2-1.11.51.61.6-1.9-1.71.9-1.1-2.11.4-0.31.60.00.0
Locomotion velocity, session 32.63.06.21.82.52.32.30.3-2.01.6-1.8-1.81.4-1.91.40.40.4
Locomotion distance, session 31.31.54.01.72.01.91.90.9-0.90.5-0.7-0.70.4-1.80.4-0.3-0.3
Stereotopy head waving bouts, day 30.70.91.50.21.00.90.9-0.7-1.21.2-1.1-1.21.2-0.41.10.50.5
Stereotopy head waving duration, day 30.91.13.1-0.40.50.40.4-1.5-1.11.4-1.3-1.81.50.01.40.50.5
Locomotion velocity, session 70.30.40.90.31.00.90.9-0.1-0.40.6-0.5-0.70.3-0.80.5-0.3-0.3
Locomotion distance, session 70.70.93.92.01.21.11.11.6-0.1-0.1-0.30.2-0.3-1.5-0.20.10.1
Stereotopy head waving bouts, day 72.12.44.20.71.21.21.2-0.5-2.01.7-2.0-1.52.0-0.71.72.12.1
Stereotopy head waving duration, day 71.92.44.40.20.90.90.9-1.1-2.11.8-2.0-1.92.1-0.31.91.71.7
Locomotion velocity, session 81.72.04.20.51.61.71.7-0.5-2.11.7-1.6-1.71.6-0.91.60.80.8
Locomotion distance, session 81.11.65.31.51.91.71.71.2-0.4-0.1-0.1-0.6-0.3-2.3-0.2-1.3-1.3
Degree of sensitization distance1.31.42.9-0.3-1.5-1.5-1.50.81.4-1.21.21.7-1.40.8-1.20.10.1
Degree of sensitization stereotypy1.01.12.20.50.80.80.8-0.2-1.41.1-1.3-0.91.3-0.51.11.51.5
Conditioned locomotion0.40.50.8-0.9-0.6-0.6-0.60.10.5-0.60.90.7-0.80.3-0.8-0.9-0.9
Cocaine response after cond. corrected1.11.74.21.22.02.12.11.1-1.21.1-1.0-1.10.6-1.70.90.10.1
Cocaine response after cond. not corrected0.50.71.90.41.21.41.40.5-0.90.8-0.6-0.70.5-0.80.60.10.1
Cocaine response before conditioning0.91.12.9-1.5-1.6-1.5-1.5-1.40.5-0.60.70.7-0.11.7-0.40.20.2
Saline control response0.60.81.8-0.4-1.4-1.3-1.3-0.00.8-0.70.71.2-0.71.2-0.70.60.6
Bone: connectivity density0.10.20.50.60.30.20.2-0.3-0.4-0.4-0.30.00.3-0.00.10.70.7
Bone: cortical apparent density0.71.12.9-1.2-1.3-1.2-1.2-1.5-0.10.1-0.10.30.51.70.31.41.4
Bone: cortical area1.32.26.2-2.5-2.0-2.1-2.1-1.50.9-0.31.31.1-0.92.0-0.6-0.4-0.4
Bone: cortical porosity0.70.81.7-1.3-1.3-1.2-1.2-0.40.6-0.60.80.6-0.61.3-0.6-0.4-0.4
Bone: cortical porosity2.62.94.4-1.9-2.1-2.1-2.1-0.21.8-1.61.91.6-1.71.8-1.6-1.3-1.3
Bone: cortical thickness0.61.02.1-1.1-1.4-1.4-1.40.00.8-0.51.11.5-1.11.0-0.80.00.0
Bone: cortical thickness0.60.71.8-0.8-1.4-1.3-1.3-0.20.30.10.20.8-0.31.3-0.10.90.9
Bone: cortical tissue density0.60.92.5-1.0-1.2-1.1-1.1-1.3-0.10.1-0.10.30.51.60.31.41.4
Condit. Reinf. active minus inactive responses0.91.02.40.41.51.51.5-0.3-1.01.1-0.9-1.20.9-1.01.00.10.1
Condit. Reinf. active-inactive response ratio0.70.82.30.21.51.51.5-0.3-0.70.7-0.6-1.00.6-0.90.7-0.2-0.2
Condit. Reinf. active responses0.81.12.5-0.01.01.11.1-0.7-1.11.6-1.1-1.21.2-0.31.30.70.7
Condit. Reinf. inactive responses0.50.61.3-0.9-0.6-0.4-0.4-1.0-0.61.1-0.5-0.50.70.90.91.01.0
Incentive salience index mean0.81.02.2-0.21.11.11.1-1.0-1.11.5-1.0-1.31.1-0.51.30.20.2
Condit. Reinf. lever presses1.01.53.9-0.9-0.1-0.1-0.1-1.7-1.22.0-1.2-1.21.50.71.71.31.3
Condit. Reinf. active minus inactive responses0.20.30.50.50.50.30.30.2-0.70.5-0.6-0.50.4-0.50.50.70.7
Condit. Reinf. active-inactive response ratio0.00.10.2-0.20.0-0.1-0.1-0.0-0.20.3-0.2-0.20.10.00.20.50.5
Condit. Reinf. active responses0.20.30.90.80.70.50.50.3-0.60.3-0.5-0.50.2-0.90.40.00.0
Condit. Reinf. inactive responses0.20.31.41.00.60.60.60.4-0.3-0.3-0.1-0.1-0.1-1.2-0.2-0.7-0.7
Condit. Reinf. lever presses2.63.814.03.72.32.22.21.8-1.80.8-1.8-0.90.9-3.11.00.90.9
Condit. Reinf. lever reinforcers received0.40.61.71.10.90.80.80.5-0.90.6-0.8-0.70.5-1.30.60.20.2
Conditioned reinforcement - actives0.20.73.30.4-0.0-0.0-0.00.1-0.70.8-0.70.20.60.40.71.81.8
Conditioned reinforcement - inactives0.20.51.00.70.90.90.9-0.0-0.21.0-0.8-0.70.8-0.50.70.70.7
Conditioned locomotion0.20.31.70.3-0.2-0.2-0.20.3-0.40.3-0.20.50.10.40.31.31.3
Patch foraging indifference point 0 sec0.20.52.71.50.30.30.31.7-0.0-0.2-0.10.2-0.3-0.9-0.40.10.1
Patch foraging indifference point AUC0.20.51.1-1.0-0.0-0.0-0.0-0.7-1.00.8-0.3-0.00.60.70.61.01.0
Delay disc. indifference point, 0s delay0.20.30.90.70.70.70.71.0-0.10.1-0.0-0.0-0.3-0.6-0.2-0.4-0.4
Delay disc. indifference point, 16s delay0.30.52.01.00.60.50.51.4-0.30.5-0.6-0.10.0-0.50.20.90.9
Delay disc. indifference point, 2s delay0.30.31.1-0.6-0.6-0.6-0.6-0.20.40.3-0.10.20.01.00.10.70.7
Delay disc. indifference point, 24s delay0.30.41.0-0.60.40.30.3-0.8-0.61.0-0.6-1.00.80.20.80.30.3
Delay disc. indifference point, 4s delay0.10.20.40.40.60.60.60.70.30.3-0.2-0.3-0.1-0.30.1-0.2-0.2
Delay disc. indifference point, 8s delay0.10.20.60.50.60.60.60.80.10.3-0.3-0.5-0.1-0.60.1-0.2-0.2
Indifference point function ln k0.10.30.90.0-0.7-0.7-0.70.10.9-0.60.30.1-0.60.3-0.3-0.4-0.4
Indifference point function log k0.10.30.90.0-0.7-0.7-0.70.10.9-0.60.30.1-0.60.3-0.3-0.4-0.4
Patch foraging total patch changes 0 sec0.20.63.41.60.40.40.41.80.0-0.2-0.20.3-0.4-1.0-0.40.30.3
Patch foraging total patch changes 12 sec0.30.41.20.40.40.40.40.5-0.80.7-0.6-0.10.5-0.20.51.11.1
Patch foraging total patch changes 18 sec0.71.52.90.81.41.41.40.0-1.71.4-1.4-1.11.3-0.81.21.31.3
Patch foraging total patch changes 24 sec0.51.74.20.71.21.21.20.4-2.01.6-1.3-0.81.2-0.31.21.91.9
Patch foraging total patch changes 6 sec1.93.28.62.72.52.42.42.0-1.80.6-1.3-1.20.7-2.90.5-0.1-0.1
Patch foraging time to switch 0 sec0.20.91.81.31.31.31.30.3-1.00.2-0.8-0.90.8-1.30.3-0.2-0.2
Patch foraging water rate 0 sec0.10.61.2-0.6-1.0-1.0-1.0-0.2-0.30.7-0.10.4-0.01.10.31.11.1
Patch foraging water rate 12 sec0.62.35.20.20.70.70.7-0.9-2.32.2-1.9-1.91.90.12.01.71.7
Patch foraging water rate 18 sec1.02.34.40.10.70.80.8-1.6-1.92.1-1.9-2.01.90.22.01.51.5
Patch foraging water rate 24 sec0.91.23.2-1.3-1.1-1.1-1.1-1.4-0.81.2-0.5-0.40.41.80.91.21.2
Patch foraging water rate 6 sec0.60.92.8-0.3-0.2-0.1-0.1-0.7-1.11.7-1.0-0.70.70.71.31.51.5
Seeking ratio, delayed vs. immediate footshock0.20.31.0-0.8-0.5-0.4-0.4-1.00.8-0.30.4-0.1-0.00.20.0-0.7-0.7
Distance traveled before self-admin0.81.74.41.41.21.21.21.8-1.20.9-1.2-0.30.7-0.70.52.12.1
Distance traveled after self-admin0.50.91.71.30.80.80.80.9-1.00.9-1.0-0.50.8-0.60.71.21.2
Extensor digitorum longus weight0.20.91.3-1.1-1.1-1.1-1.1-0.70.5-0.91.00.6-0.70.8-0.9-1.1-1.1
Bone: elastic displacement0.70.83.61.30.50.50.51.90.5-0.90.61.0-1.0-1.0-1.0-0.4-0.4
Bone: elastic work0.10.10.4-0.5-0.2-0.2-0.20.10.20.50.10.3-0.10.70.20.40.4
Bone: endosteal estimation0.41.06.0-1.5-0.7-0.7-0.7-2.4-0.30.5-0.1-0.90.71.30.7-0.3-0.3
Bone: endosteal perimeter0.61.56.5-2.3-1.3-1.4-1.4-2.60.50.10.5-0.20.31.80.3-0.2-0.2
Epididymis fat weight0.52.64.92.12.01.91.90.3-2.21.3-1.5-1.81.3-2.21.2-0.0-0.0
Delta time in closed arm before/after self-admin1.71.63.7-0.20.60.60.6-1.2-1.31.6-1.5-1.51.90.21.61.61.6
Delta time in open arm before/after self-admin1.01.22.1-0.8-0.9-0.9-0.90.71.3-1.51.31.1-1.30.8-1.3-1.1-1.1
Diff in mean of infusions in LGA sessions0.30.51.30.30.50.50.5-0.8-0.60.7-1.0-1.11.1-0.40.90.40.4
Delay discount exponential model param0.00.10.3-0.1-0.2-0.2-0.2-0.5-0.3-0.30.20.20.1-0.0-0.0-0.1-0.1
Extinction: sum of active levers before priming1.11.74.0-0.11.11.11.1-1.7-1.71.6-1.4-2.01.7-0.51.60.10.1
Active lever presses in extinction session 61.31.32.71.71.11.11.10.3-1.50.8-1.4-1.21.2-1.31.00.80.8
Bone: final force0.60.91.9-1.1-1.4-1.3-1.3-0.50.9-0.31.01.0-1.01.1-0.6-0.7-0.7
Bone: final moment0.50.81.7-1.1-1.3-1.2-1.2-0.60.8-0.20.90.7-0.81.0-0.5-0.7-0.7
Food consumed during 24 hour testing period0.51.01.9-0.10.60.60.6-1.4-0.91.1-1.2-1.41.30.21.30.90.9
Glucose0.71.04.2-1.8-0.8-0.8-0.8-2.10.10.7-0.3-0.70.81.60.70.50.5
Heart weight1.21.93.70.10.60.50.5-1.5-1.61.7-1.7-1.81.90.11.81.61.6
Delay discount hyperbolic model param0.00.10.3-0.1-0.1-0.1-0.1-0.6-0.4-0.30.10.00.2-0.00.0-0.1-0.1
Intermittent access intake day 1-15 change0.31.46.0-0.7-0.3-0.3-0.3-0.5-1.01.3-0.90.00.91.31.02.52.5
Intermittent access intake escalation0.31.66.2-0.7-0.00.00.0-0.7-1.11.6-1.1-0.31.11.21.32.52.5
Intermittent access intake escalation 20.91.44.7-1.9-1.4-1.4-1.4-1.4-0.10.80.00.30.32.20.41.21.2
Intermitt. access day 1 inactive lever presses0.33.46.1-2.4-1.6-1.6-1.6-0.72.3-1.42.21.1-1.71.6-1.6-2.5-2.5
Intermitt. access day 15 inactive lever presses0.00.30.5-0.6-0.5-0.5-0.5-0.20.6-0.60.60.5-0.40.7-0.5-0.3-0.3
Intermitt. access escalation Index0.51.55.60.40.00.00.01.00.8-1.41.10.4-1.1-1.0-1.3-2.4-2.4
Intermittent access day 1 total infusions0.41.12.61.61.51.51.50.9-0.70.7-0.8-0.70.4-1.50.60.10.1
Intermittent access day 15 total infusions0.71.72.51.11.61.61.60.6-1.31.5-1.4-0.91.1-0.71.21.51.5
Intermittent access terminal intake (last 3 days)1.11.93.90.71.61.61.6-0.2-1.52.0-1.5-1.41.5-0.51.61.21.2
Intermittent access total infusions2.22.64.31.22.12.12.1-0.1-1.62.0-1.8-1.61.7-1.01.71.31.3
Intermittent access day 1 locomotion0.10.20.50.30.70.70.7-0.0-0.50.5-0.3-0.50.3-0.50.5-0.1-0.1
Intermittent access day 15 total locomotion0.31.03.00.40.60.60.6-0.3-1.41.3-1.1-0.51.0-0.11.21.71.7
Intermittent access total locomotion2.22.75.1-0.11.21.21.2-1.5-2.02.3-1.8-1.82.00.02.21.71.7
Intermittent access standard deviation0.10.72.11.30.60.60.61.4-0.60.2-0.50.50.1-0.40.11.51.5
Left kidney weight0.10.71.7-0.0-0.9-1.0-1.00.70.9-1.10.91.3-1.10.4-1.1-0.1-0.1
Right kidney weight0.21.32.80.6-0.4-0.5-0.51.31.6-1.71.41.6-1.5-0.3-1.6-0.7-0.7
Cocaine induced anxiety0.30.81.9-0.9-1.1-1.1-1.10.00.9-0.90.81.0-0.81.4-0.9-0.0-0.0
Post-drug Anxiety1.01.12.9-1.7-1.3-1.3-1.3-0.70.9-0.81.00.6-0.71.4-0.9-0.7-0.7
Baseline Anxiety0.10.10.4-0.30.00.00.0-0.4-0.20.30.0-0.50.2-0.60.1-0.6-0.6
Tail length0.00.10.20.2-0.5-0.4-0.40.20.3-0.50.10.3-0.1-0.1-0.40.00.0
Length with tail0.00.20.8-0.5-0.3-0.3-0.3-0.90.10.3-0.4-0.40.50.50.30.60.6
Length without tail0.10.51.3-0.60.1-0.0-0.0-1.2-0.20.8-0.8-0.80.90.70.91.01.0
Times rat made contact with spout0.50.61.50.90.90.90.90.2-0.0-0.2-0.1-0.6-0.1-1.2-0.1-1.1-1.1
Lifetime Intake2.53.14.81.82.22.22.20.6-1.52.0-1.9-1.31.6-1.21.71.81.8
Liver weight, left0.30.52.41.50.40.30.30.6-0.60.2-0.60.20.2-0.50.31.11.1
Liver weight, right0.81.33.1-1.3-1.5-1.4-1.4-0.10.6-0.81.01.8-0.91.3-0.91.01.0
Locomotor activity0.20.30.50.50.40.50.5-0.7-0.40.4-0.6-0.40.6-0.30.60.60.6
Locomotor testing distance0.30.72.0-0.2-0.4-0.3-0.3-1.4-0.70.8-0.7-0.40.90.60.91.31.3
Locomotor testing rearing0.00.20.6-0.3-0.8-0.6-0.6-0.5-0.1-0.30.20.5-0.10.4-0.20.40.4
Locomotion in novel chamber0.20.31.00.2-0.4-0.5-0.50.3-0.8-0.5-0.30.40.4-0.1-0.11.01.0
Locomotion in novel chamber post-restriction0.20.52.21.50.70.70.70.9-0.7-0.2-0.2-0.20.1-1.3-0.1-0.4-0.4
Fecal boli incidents, locomotor time 10.30.91.80.40.70.70.7-0.1-1.10.9-1.3-1.11.3-0.31.01.21.2
Change in fecal boli incidents, locomotor task0.10.10.70.80.20.20.20.3-0.50.3-0.3-0.0-0.0-0.50.30.50.5
Time >=10cm from walls, locomotor time 12.63.36.3-2.3-2.5-2.5-2.5-1.21.7-1.21.71.3-1.32.2-1.2-1.3-1.3
Bouts of movement, locomotor time 10.81.02.30.70.60.60.61.40.8-1.10.80.6-1.0-1.2-1.0-1.5-1.5
Total resting periods, locomotor time 10.81.01.90.90.60.60.61.30.7-1.20.70.6-0.9-1.2-1.0-1.4-1.4
Rest time, locomotor task time 10.61.02.51.21.21.21.2-0.3-1.60.5-1.0-1.01.1-1.30.80.30.3
Distance moved, locomotor task time 11.43.88.3-2.5-2.9-2.9-2.9-0.61.5-1.01.82.1-1.42.8-1.30.00.0
Vertical activity count, locomotor time 10.21.63.7-1.7-1.8-1.9-1.9-0.51.1-0.51.11.3-0.91.9-0.8-0.1-0.1
Time >=10cm from walls, locomotor time 20.00.00.10.2-0.3-0.3-0.3-0.3-0.30.0-0.10.00.10.20.10.10.1
Bouts of movement, locomotor time 20.30.94.2-0.60.20.20.20.50.8-0.71.00.0-0.8-0.3-0.8-2.1-2.1
Total resting periods, locomotor time 20.20.73.9-0.60.40.30.30.20.6-0.40.7-0.3-0.5-0.3-0.5-2.0-2.0
Rest time, locomotor task time 20.20.30.8-0.3-0.4-0.4-0.4-0.10.5-0.70.60.2-0.40.3-0.7-0.9-0.9
Distance moved, locomotor task time 20.30.41.30.1-0.5-0.5-0.51.0-0.3-0.10.31.1-0.50.2-0.31.01.0
Vertical activity count, locomotor time 20.10.31.1-0.0-0.4-0.4-0.41.10.0-0.60.61.0-0.80.0-0.80.20.2
Light reinforcement 10.21.02.91.71.51.41.40.4-0.70.1-0.9-0.70.5-1.50.30.10.1
Light reinforcement 20.10.20.6-0.30.40.50.50.1-0.1-0.10.3-0.2-0.3-0.1-0.3-0.8-0.8
Bone: marrow area0.41.16.4-1.6-0.8-0.8-0.8-2.5-0.20.5-0.1-0.80.71.40.6-0.2-0.2
Bone: maximum diameter2.44.715.3-3.9-2.8-2.8-2.8-2.61.4-0.71.91.2-1.03.1-0.8-0.9-0.9
Bone: maximum force1.02.04.4-2.1-2.0-2.0-2.0-1.31.0-0.11.31.1-1.02.1-0.5-0.6-0.6
Bone: maximum moment1.01.84.2-2.1-1.8-1.9-1.9-1.50.9-0.11.20.9-0.82.0-0.4-0.6-0.6
Mean time between licks in bursts0.10.51.9-0.60.00.00.00.00.4-0.50.90.4-0.8-0.5-0.7-1.4-1.4
Mean num. licks in bursts0.20.41.20.0-0.1-0.1-0.10.20.6-0.90.80.5-0.6-0.1-0.9-1.1-1.1
Cd content in liver0.91.02.01.41.21.21.20.5-0.80.4-1.1-0.70.9-1.10.61.01.0
Co content in liver1.01.22.5-0.80.50.50.5-1.3-1.21.6-1.2-1.61.50.51.50.70.7
Cu content in liver0.50.61.1-0.5-1.1-1.0-1.00.50.7-0.80.70.9-0.70.8-0.8-0.0-0.0
Fe content in liver0.20.20.80.2-0.4-0.4-0.40.1-0.10.1-0.30.30.10.70.10.90.9
K content in liver1.21.12.9-0.2-0.2-0.2-0.20.61.3-1.11.41.0-1.4-0.2-1.4-1.7-1.7
Mg content in liver1.01.13.91.20.50.50.52.00.8-0.70.91.2-1.3-1.1-1.2-0.8-0.8
Mn content in liver1.01.13.00.4-0.3-0.2-0.21.71.1-0.91.21.7-1.7-0.3-1.4-0.5-0.5
Na content in liver2.42.78.82.22.22.32.31.5-0.3-0.2-0.2-0.6-0.3-3.0-0.3-1.6-1.6
Rb content in liver0.40.51.2-0.9-0.2-0.3-0.3-1.1-0.50.9-0.6-0.50.70.80.80.90.9
Se content in liver2.73.212.02.50.50.60.63.51.2-2.01.22.1-2.1-1.9-2.1-0.7-0.7
Sr content in liver0.20.20.60.20.30.30.30.70.5-0.70.40.4-0.5-0.2-0.7-0.4-0.4
Zn content in liver0.10.20.50.70.30.30.30.4-0.60.4-0.4-0.20.3-0.40.30.30.3
Bone: minimum diameter1.12.16.4-2.5-1.9-1.9-1.9-2.30.6-0.21.00.5-0.32.2-0.2-0.4-0.4
Time in familiar zone, hab. session 10.30.41.0-0.9-0.3-0.3-0.3-0.7-0.40.4-0.30.00.41.00.41.01.0
Time in novel zone, hab. session 10.70.81.3-0.1-0.8-0.9-0.90.31.0-1.21.00.8-1.0-0.0-1.0-1.0-1.0
Total zone transitions, hab. session 11.52.15.60.61.41.21.2-0.1-1.91.6-1.5-0.81.3-0.41.42.42.4
Total locomotion distance, hab. session 10.30.51.80.6-0.0-0.1-0.11.0-0.2-0.40.00.9-0.30.1-0.41.31.3
Locomotion velocity, hab. session 10.40.52.20.80.50.40.40.9-0.60.2-0.40.40.1-0.20.11.51.5
Time in familiar zone, hab. session 21.71.95.3-1.5-2.3-2.1-2.1-0.60.7-0.80.91.5-0.52.0-0.70.70.7
Time in novel zone, hab. session 21.71.84.61.22.12.02.00.1-1.01.1-1.2-1.80.9-1.61.1-0.2-0.2
Total zone transitions, hab. session 20.30.41.20.70.90.80.81.10.2-0.40.40.6-0.8-0.8-0.5-0.2-0.2
Total locomotion distance, hab. session 20.81.12.70.4-0.3-0.4-0.41.40.9-1.41.31.6-1.6-0.2-1.4-0.6-0.6
Locomotion velocity, hab. session 20.60.81.90.4-0.1-0.2-0.21.30.8-1.21.11.4-1.3-0.2-1.2-0.4-0.4
Novel to familiar place preference ratio0.81.12.10.40.20.10.11.41.4-1.21.00.7-1.2-0.7-1.2-1.5-1.5
Novelty place preference1.01.32.60.30.1-0.0-0.01.41.6-1.41.10.8-1.3-0.7-1.4-1.6-1.6
Time in novel zone, NPP test0.91.12.60.1-0.0-0.1-0.11.11.5-1.31.10.8-1.2-0.5-1.3-1.6-1.6
Total zone transitions, NPP test1.32.04.50.51.81.61.6-0.6-2.11.6-1.4-1.51.4-0.81.51.11.1
Total locomotion distance, NPP test0.30.41.51.00.20.10.11.2-0.1-0.50.41.0-0.7-0.4-0.60.40.4
Locomotion velocity, NPP test0.30.41.50.8-0.1-0.2-0.21.20.1-0.70.61.2-0.8-0.3-0.70.30.3
Intraocular pressure1.11.74.7-0.61.01.01.0-1.8-1.61.9-1.3-2.21.7-0.01.70.10.1
Delta distance traveled before/after self-admin0.40.51.0-0.6-1.0-1.0-1.0-1.00.7-0.00.40.2-0.00.80.0-0.5-0.5
Delta ambulatory time before/after self-admin0.20.41.20.1-0.5-0.5-0.5-0.20.8-0.40.70.5-0.60.0-0.4-1.1-1.1
Parametrial fat weight0.92.13.4-0.9-1.8-1.9-1.90.41.5-1.61.71.6-1.60.9-1.6-1.0-1.0
Pavlov. Cond. lever latency0.50.61.41.00.60.70.71.20.2-0.80.40.2-0.6-0.9-0.7-1.0-1.0
Pavlov. Cond. magazine entry latency0.00.10.2-0.1-0.3-0.2-0.20.10.0-0.20.10.5-0.3-0.2-0.20.30.3
Pavlov. Cond. change in total contacts0.10.10.3-0.5-0.4-0.3-0.3-0.40.20.10.10.2-0.10.30.10.10.1
Pavlov. Cond. index score0.20.30.6-0.8-0.7-0.6-0.6-0.70.00.3-0.10.10.20.50.30.70.7
Pavlov. Cond. latency score0.20.30.6-0.7-0.5-0.5-0.5-0.8-0.10.4-0.2-0.10.40.50.40.60.6
Pavlov. Cond. lever contacts0.40.51.4-1.2-1.0-1.1-1.1-1.00.40.10.20.30.00.90.00.30.3
Pavlov. Cond. magazine entry number0.10.10.30.30.50.40.4-0.0-0.30.1-0.2-0.60.3-0.10.2-0.4-0.4
Pavlov. Cond. intertrial magazine entries0.81.02.20.7-0.1-0.1-0.11.20.9-1.11.10.9-1.3-0.6-1.3-1.5-1.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.8-0.7-0.7-0.7-0.70.10.20.00.20.10.50.20.60.6
Pavlov. Cond. response bias0.40.41.0-0.6-1.0-0.9-0.9-0.10.4-0.10.30.9-0.40.7-0.20.80.8
Pavlov. Cond. lever latency1.82.511.9-3.4-1.6-1.7-1.7-2.01.3-0.31.10.0-0.32.4-0.3-1.0-1.0
Pavlov. Cond. magazine entry latency0.30.41.51.20.70.70.71.0-0.5-0.0-0.20.2-0.0-1.0-0.00.10.1
Pavlov. Cond. change in total contacts0.71.86.22.51.61.71.71.4-1.30.3-0.8-0.30.3-2.10.40.60.6
Pavlov. Cond. index score1.32.07.72.81.61.71.71.4-1.50.4-1.1-0.30.5-2.20.50.70.7
Pavlov. Cond. latency score1.01.76.22.51.41.51.51.2-1.50.6-1.1-0.30.6-1.80.60.90.9
Pavlov. Cond. lever contacts2.03.013.13.61.92.02.02.1-1.50.4-1.2-0.20.4-2.70.40.90.9
Pavlov. Cond. magazine entry number0.70.93.4-1.8-1.1-1.1-1.1-1.60.60.30.1-0.40.31.50.30.00.0
Pavlov. Cond. intertrial magazine entries0.61.23.6-1.7-1.5-1.5-1.5-1.31.0-0.60.50.3-0.11.9-0.30.20.2
Pavlov. Cond. lever-magazine prob. diff.1.21.97.22.71.61.61.61.4-1.50.4-1.1-0.30.5-2.10.40.70.7
Pavlov. Cond. response bias1.92.610.73.31.91.91.92.1-1.30.2-1.0-0.10.2-2.60.20.60.6
Time in closed arm before self-admin0.40.81.60.0-0.7-0.7-0.71.11.2-0.91.01.2-1.20.4-1.0-0.6-0.6
Time in closed arm after self-admin0.50.52.00.1-0.7-0.7-0.70.70.20.2-0.00.8-0.10.7-0.01.41.4
Time in open arm before self-admin0.30.41.1-0.1-0.4-0.4-0.4-0.9-0.70.5-0.5-0.30.60.10.71.11.1
Time in open arm after self-admin0.50.51.9-1.1-0.8-0.8-0.8-1.40.2-0.40.3-0.3-0.00.8-0.0-0.8-0.8
Bone: periosteal estimation0.82.06.6-2.6-1.7-1.7-1.7-2.40.6-0.10.90.2-0.32.0-0.1-0.8-0.8
Bone: periosteal perimeter1.02.04.8-2.2-1.9-2.0-2.0-1.51.1-0.51.31.0-0.81.9-0.6-0.5-0.5
Bone: post-yield work1.11.87.3-1.9-1.5-1.6-1.6-2.7-0.00.5-0.1-0.30.72.30.60.70.7
Progressive ratio test 1 active lever presses0.71.22.21.41.51.51.50.6-1.01.0-1.0-0.60.7-1.00.91.01.0
Progressive ratio test 1 breakpoint0.71.22.61.61.51.51.50.8-0.90.8-0.9-0.50.6-1.10.70.90.9
Progressive ratio test 1 inactive lever presses0.10.30.50.10.50.50.50.70.5-0.40.60.4-0.7-0.2-0.6-0.7-0.7
Progressive ratio test 2 active lever presses1.92.63.71.21.91.91.9-0.4-1.61.9-1.8-1.51.8-1.01.81.61.6
Progressive ratio test 2 breakpoint2.12.73.71.01.91.91.9-0.5-1.71.9-1.8-1.61.9-0.91.91.61.6
Progressive ratio test 2 inactive lever presses0.30.92.50.51.61.61.60.1-0.81.0-0.7-0.90.7-0.80.80.40.4
Incentive Sensitization - Responses1.02.74.60.11.41.41.4-1.3-1.72.2-1.9-1.82.1-0.32.11.81.8
Incentive Sensitization - Breakpoint1.33.05.30.01.51.41.4-1.5-1.92.3-2.0-2.02.3-0.22.31.91.9
Sum of active levers in priming session hrs 5-62.22.13.50.71.31.31.3-1.0-1.91.6-1.8-1.61.8-0.71.61.41.4
Progressive ratio0.10.31.7-1.0-0.6-0.6-0.6-1.30.10.10.1-0.10.20.70.2-0.1-0.1
Food seeking constrained by brief footshock2.93.66.10.81.71.81.8-1.5-2.12.3-2.4-2.42.2-0.42.51.81.8
Seeking ratio, punishment vs. effort0.61.32.41.01.11.21.20.4-1.21.3-1.3-0.80.9-0.51.11.51.5
Retroperitoneal fat weight0.62.65.70.5-0.5-0.7-0.71.41.5-2.21.71.4-2.1-0.9-2.0-2.4-2.4
Reaction time number correct0.10.51.61.30.20.20.21.1-0.50.5-0.60.20.1-0.60.31.01.0
Reaction time mean minus median0.53.46.5-0.9-1.9-2.0-2.01.02.2-2.22.32.5-2.31.1-2.1-1.0-1.0
Reaction time mean minus median AUC0.64.37.4-1.3-2.1-2.2-2.20.82.6-2.52.52.7-2.51.3-2.3-1.3-1.3
Reaction time num false alarms0.40.71.9-1.4-1.0-1.0-1.0-0.71.1-0.30.60.6-0.31.4-0.20.10.1
Reaction time num false alarms AUC0.41.03.5-1.9-1.0-1.0-1.0-1.50.60.20.10.00.31.80.40.60.6
Reaction time trials correct on left0.10.51.61.30.20.20.21.1-0.50.5-0.60.20.1-0.60.31.01.0
Reaction time trials on left0.10.41.61.30.20.10.11.2-0.40.4-0.50.3-0.1-0.60.20.90.9
Reaction time mean1.73.85.7-1.0-2.0-2.1-2.10.62.4-2.32.42.4-2.31.2-2.2-1.5-1.5
Reaction time mean AUC2.04.97.4-1.3-2.4-2.5-2.50.62.7-2.62.72.7-2.51.5-2.4-1.6-1.6
Median of all reaction times1.82.94.3-1.0-1.8-2.0-2.00.42.1-2.02.02.0-1.91.2-1.9-1.3-1.3
Reaction time omissions2.43.97.5-0.2-1.0-1.2-1.21.52.4-2.62.62.7-2.7-0.1-2.5-2.0-2.0
Reaction time false alarm rate0.70.94.3-2.1-0.8-0.8-0.8-1.70.8-0.10.4-0.20.21.60.2-0.2-0.2
Reaction time premature initiation rate0.50.73.21.60.50.50.51.81.0-0.20.30.6-0.8-0.9-0.5-0.5-0.5
Reaction time premature initiations0.30.84.41.90.50.50.52.10.70.00.10.7-0.8-1.0-0.4-0.0-0.0
Std. dev. reaction times1.65.28.7-1.3-2.3-2.4-2.41.02.8-2.62.93.0-2.81.3-2.6-1.7-1.7
Reaction time trials completed0.10.41.61.30.20.10.11.2-0.40.4-0.50.3-0.1-0.60.20.90.9
Reaction time trials AUC0.20.51.81.30.30.20.21.1-0.60.6-0.70.10.2-0.70.31.11.1
Run reversals in cocaine runway, females0.10.10.40.10.60.60.60.60.1-0.2-0.0-0.30.0-0.2-0.1-0.1-0.1
Run reversals in cocaine runway, males0.10.10.40.1-0.1-0.1-0.10.60.1-0.50.40.5-0.4-0.1-0.5-0.4-0.4
Latency to leave start box in cocaine runway0.81.02.30.80.60.50.5-0.2-1.31.1-1.3-0.81.2-0.31.21.51.5
Latency to leave start box in cocaine runway, F0.81.03.51.50.40.40.41.4-0.80.5-0.90.30.4-0.50.41.91.9
Latency to leave start box in cocaine runway, M0.90.93.7-0.80.10.10.1-1.9-1.01.0-0.8-1.41.30.41.20.20.2
Std. dev. time between licks in bursts0.81.42.9-0.7-1.0-1.0-1.00.11.2-1.41.51.1-1.50.1-1.4-1.7-1.7
Total sessions with >9 infusions1.31.64.22.01.71.71.71.0-0.71.1-1.2-0.60.8-1.40.91.11.1
Short access day 1 total inactive lever presses0.71.33.10.70.80.80.80.1-1.11.5-1.3-0.91.3-0.31.31.81.8
Short access day 10 total inactive lever presses0.21.72.9-0.5-1.1-1.1-1.11.01.5-1.31.71.6-1.60.3-1.6-1.3-1.3
Short access day 1 total infusions0.81.66.62.61.11.11.12.2-0.40.7-0.70.30.2-1.50.31.31.3
Short access day 10 total infusions2.13.45.62.42.32.32.31.1-1.61.8-2.0-1.21.5-1.71.61.91.9
Short access total infusions1.82.56.12.51.91.91.91.4-1.01.3-1.5-0.51.0-1.61.11.71.7
Short access day 1 locomotion0.71.15.11.50.60.60.62.30.9-0.90.71.1-1.1-1.0-1.0-0.5-0.5
Short access day 10 total locomotion0.20.92.11.11.01.01.00.8-1.00.8-0.9-0.30.6-0.70.81.41.4
Short access total locomotion0.91.42.41.41.61.51.50.6-1.01.0-1.1-0.60.8-1.01.01.31.3
One hour access (0.3 mA shock)1.41.63.11.11.51.51.50.0-1.11.8-1.4-1.21.3-1.01.41.11.1
Compulsive drug intake0.00.10.2-0.3-0.0-0.0-0.00.4-0.30.20.10.4-0.30.0-0.10.30.3
One hour access (shock baseline)0.61.72.51.01.61.61.6-0.3-1.01.6-1.5-1.51.5-0.91.50.90.9
Social response proportion0.10.20.40.4-0.1-0.2-0.20.60.1-0.70.50.6-0.4-0.3-0.6-0.2-0.2
Social responses0.81.13.21.0-0.3-0.4-0.41.80.7-1.31.11.6-1.4-0.5-1.4-0.3-0.3
Social time0.61.04.41.8-0.4-0.3-0.32.10.1-1.10.31.3-0.8-0.5-0.90.70.7
Soleus weight9.126.747.1-0.33.43.33.3-5.3-6.46.7-6.2-6.76.9-0.46.85.05.0
Bone: stiffness2.34.27.3-2.7-2.7-2.7-2.7-1.51.7-1.02.11.5-1.62.6-1.3-1.8-1.8
Tibialis anterior weight0.93.15.60.11.00.90.9-1.7-2.32.1-2.2-2.02.4-0.02.12.12.1
Time to tail flick, vehicle, before self-admin0.80.92.9-0.90.00.00.0-1.7-0.91.0-0.9-0.71.10.81.11.31.3
Time to tail flick, vehicle, after self-admin0.61.23.7-1.5-1.0-1.0-1.0-1.1-0.00.8-0.40.00.71.90.71.61.6
Time to tail flick, test, before self-admin0.91.11.8-0.01.21.21.2-0.8-1.31.3-1.0-1.31.1-0.51.30.40.4
Time to tail flick, test, after self-admin2.42.65.7-0.60.90.90.9-1.7-2.12.4-1.8-2.22.00.22.31.11.1
Delta time to tail flick, vehicle, before/after SA0.30.30.9-0.0-0.3-0.3-0.30.60.8-0.30.60.3-0.60.1-0.5-1.0-1.0
Delta time to tail flick, test, before/after SA0.10.10.20.20.10.10.10.2-0.30.5-0.4-0.40.3-0.00.30.30.3
Tibia length0.00.00.20.00.10.10.10.1-0.10.3-0.3-0.00.1-0.10.10.40.4
Ambulatory time before self-admin0.41.15.31.40.90.90.92.3-0.60.3-0.60.3-0.0-0.6-0.01.41.4
Ambulatory time after self-admin0.20.31.71.10.40.40.41.3-0.30.3-0.40.00.2-0.30.10.70.7
Bone: tissue strength0.60.61.9-0.8-0.0-0.1-0.1-1.4-0.60.9-0.7-0.70.90.61.00.90.9
Total heroin consumption1.11.32.20.91.51.51.5-0.5-1.31.3-1.2-1.41.2-1.21.10.30.3
Bone: trabecular number0.20.41.80.60.40.30.3-0.0-0.70.3-0.7-0.10.50.10.51.31.3
Bone: trabecular spacing0.30.51.5-0.8-0.2-0.3-0.3-1.20.30.60.1-0.80.40.30.5-1.2-1.2
Bone: trabecular thickness0.10.10.40.1-0.10.10.1-0.2-0.60.2-0.4-0.40.3-0.00.30.20.2
Bone: trabecular tissue density0.61.12.3-0.4-0.8-0.9-0.91.01.1-1.51.21.4-1.30.1-1.4-0.8-0.8
Water consumed over 24 hours0.10.10.4-0.00.40.40.4-0.4-0.3-0.1-0.1-0.60.2-0.20.1-0.6-0.6
Number of responses in last shaping day1.82.33.50.81.91.91.9-0.5-1.51.8-1.7-1.71.7-1.01.71.11.1