Hub : Genes

Cacna2d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Cacna2d1	0.53	0.11	0.0e+00	0.12	0.16	0.15	0.16	2.6e-13	9.9e-18	8.7e-17	1.5e-17
2	LHb	alternative TSS	NM_001110847.1	0.16	0.11	8.8e-03	-0.01	0	-0	-0.01	8.0e-01	2.8e-01	4.5e-01	5.1e-01
3	LHb	alternative TSS	NM_001110847.1	0.16	0.11	8.7e-03	-0.01	0	-0	-0.01	8.0e-01	2.8e-01	4.5e-01	5.2e-01
4	Brain	gene expression	Cacna2d1	0.15	0.09	3.3e-16	0.19	0.17	0.18	0.18	4.9e-17	1.5e-15	1.7e-16	5.7e-17

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.6
Area under the delay curve	0.0	0.0	0.1	0.3	-0.0	-0.0	-0.0
BMI with tail	0.1	0.2	0.6	0.2	0.4	0.4	-0.8
BMI without tail	0.5	1.0	3.6	0.2	0.3	0.3	-1.9
Body weight	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2
Weight adjusted by age	0.0	0.0	0.0	-0.2	-0.2	-0.2	-0.1
Bone surface	0.2	0.3	0.5	-0.2	0.7	0.7	0.5
Bone volume	0.1	0.2	0.8	-0.4	0.1	0.1	0.9
Breakpoint value in progressive ratio session	0.1	0.2	0.2	0.1	-0.5	-0.5	-0.4
Number of licking bursts	0.6	0.7	1.0	-0.5	-0.9	-0.9	1.0
Context. condit. distance diff. score	0.4	0.5	0.7	0.3	-0.7	-0.7	-0.8
Locomotion velocity, session 1	2.3	2.4	2.9	-1.7	-1.5	-1.5	1.5
Locomotion distance, session 1	4.9	6.3	9.7	-3.1	-1.9	-1.9	2.9
Locomotion velocity, session 2	0.2	0.3	0.4	-0.6	-0.5	-0.5	0.2
Locomotion distance, session 2	1.4	2.0	5.0	-2.2	-0.7	-0.7	1.4
Locomotion velocity, session 3	3.1	3.6	4.7	-1.9	-2.2	-2.2	1.3
Locomotion distance, session 3	1.3	1.4	2.0	-1.2	-1.4	-1.4	0.4
Stereotopy head waving bouts, day 3	1.0	1.2	1.3	-1.1	-1.1	-1.1	1.2
Stereotopy head waving duration, day 3	1.0	1.2	2.4	-0.9	-0.9	-0.9	1.5
Locomotion velocity, session 7	0.3	0.3	0.4	-0.6	-0.6	-0.6	0.3
Locomotion distance, session 7	0.2	0.3	0.6	-0.0	-0.8	-0.8	-0.2
Stereotopy head waving bouts, day 7	2.1	2.3	2.9	-1.7	-1.3	-1.3	1.7
Stereotopy head waving duration, day 7	2.4	3.0	4.1	-1.8	-1.5	-1.5	2.0
Locomotion velocity, session 8	2.5	2.9	4.7	-2.2	-1.5	-1.5	1.6
Locomotion distance, session 8	0.8	1.1	1.5	-1.1	-1.2	-1.2	-0.3
Degree of sensitization distance	2.1	2.1	3.1	1.8	1.4	1.4	-1.2
Degree of sensitization stereotypy	1.4	1.5	2.1	-1.5	-1.1	-1.1	1.2
Conditioned locomotion	0.4	0.5	0.9	-0.1	0.7	0.7	-0.9
Cocaine response after cond. corrected	1.4	1.6	2.3	-1.2	-1.5	-1.5	0.6
Cocaine response after cond. not corrected	0.4	0.5	0.9	-0.9	-0.7	-0.7	0.4
Cocaine response before conditioning	0.8	1.0	1.9	0.3	1.4	1.4	-0.3
Saline control response	0.7	0.9	1.0	1.0	1.0	1.0	-0.8
Bone: connectivity density	0.2	0.3	0.5	-0.5	-0.5	-0.5	0.7
Bone: cortical apparent density	0.4	0.5	0.8	0.2	0.9	0.9	0.5
Bone: cortical area	1.6	2.5	3.9	1.2	2.0	2.0	-0.7
Bone: cortical porosity	1.1	1.2	1.9	0.9	1.4	1.4	-0.5
Bone: cortical porosity	4.2	4.6	5.8	2.0	2.4	2.4	-1.7
Bone: cortical thickness	0.8	1.3	1.6	1.2	1.2	1.3	-0.9
Bone: cortical thickness	0.4	0.5	0.7	0.8	0.8	0.8	-0.2
Bone: cortical tissue density	0.3	0.4	0.7	0.2	0.8	0.8	0.5
Condit. Reinf. active minus inactive responses	1.3	1.4	2.5	-1.6	-1.1	-1.1	0.8
Condit. Reinf. active-inactive response ratio	0.8	0.9	1.4	-1.2	-1.0	-1.0	0.6
Condit. Reinf. active responses	1.1	1.4	3.0	-1.7	-0.9	-0.9	1.1
Condit. Reinf. inactive responses	0.3	0.3	0.7	-0.8	0.3	0.3	0.7
Incentive salience index mean	1.2	1.5	3.1	-1.8	-1.0	-1.0	1.0
Condit. Reinf. lever presses	0.9	1.2	2.3	-1.5	-0.3	-0.3	1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.9	-1.0	-0.3	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.5	0.1	0.1	0.2
Condit. Reinf. active responses	0.3	0.4	1.1	-1.0	-0.6	-0.6	0.0
Condit. Reinf. inactive responses	0.3	0.3	0.4	-0.6	-0.6	-0.6	-0.4
Condit. Reinf. lever presses	3.6	4.8	7.4	-2.0	-2.7	-2.7	0.7
Condit. Reinf. lever reinforcers received	0.6	0.8	1.7	-1.3	-0.9	-0.9	0.2
Conditioned reinforcement - actives	1.0	1.0	1.5	-1.1	-0.7	-0.7	1.2
Conditioned reinforcement - inactives	0.6	0.6	0.9	0.6	-0.8	-0.8	1.0
Conditioned locomotion	0.1	0.1	0.2	-0.5	-0.1	-0.1	0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.1	0.1	-0.3	-0.3	-0.3
Patch foraging indifference point AUC	0.5	0.6	2.0	-1.4	-0.1	-0.1	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.1	-0.2	-0.3	-0.3	0.3
Delay disc. indifference point, 2s delay	0.4	0.5	0.7	0.8	0.8	0.8	-0.2
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	-0.4	-0.1	-0.1	0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.5	-0.2	-0.2	-0.1
Delay disc. indifference point, 8s delay	0.0	0.0	0.1	0.3	-0.2	-0.2	-0.0
Indifference point function ln k	0.3	0.4	0.9	1.0	0.4	0.4	-0.4
Indifference point function log k	0.3	0.4	0.9	1.0	0.4	0.4	-0.4
Patch foraging total patch changes 0 sec	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.5
Patch foraging total patch changes 12 sec	0.2	0.2	0.5	-0.7	-0.4	-0.4	0.3
Patch foraging total patch changes 18 sec	1.4	1.9	4.1	-2.0	-1.1	-1.1	1.0
Patch foraging total patch changes 24 sec	1.3	1.6	5.0	-2.2	-0.5	-0.5	1.0
Patch foraging total patch changes 6 sec	3.2	4.8	6.3	-2.5	-2.5	-2.5	0.5
Patch foraging time to switch 0 sec	1.3	2.0	2.7	-1.4	-1.6	-1.6	0.7
Patch foraging water rate 0 sec	0.4	0.6	1.1	0.5	1.0	1.0	0.0
Patch foraging water rate 12 sec	1.5	2.3	4.0	-2.0	-1.0	-1.0	1.8
Patch foraging water rate 18 sec	1.6	2.1	4.3	-1.8	-0.7	-0.7	2.1
Patch foraging water rate 24 sec	0.5	0.6	1.1	-0.4	1.0	1.0	0.6
Patch foraging water rate 6 sec	0.3	0.4	0.9	-1.0	0.2	0.2	0.8
Seeking ratio, delayed vs. immediate footshock	0.2	0.2	0.8	0.9	0.1	0.1	0.0
Distance traveled before self-admin	1.5	1.6	2.2	-1.5	-1.2	-1.2	1.2
Distance traveled after self-admin	0.3	0.4	0.4	-0.4	-0.6	-0.6	0.6
Extensor digitorum longus weight	0.2	0.8	1.2	0.4	1.1	1.1	-0.8
Bone: elastic displacement	0.2	0.2	0.7	0.4	-0.1	-0.1	-0.9
Bone: elastic work	0.2	0.3	0.5	0.7	0.5	0.5	0.1
Bone: endosteal estimation	0.2	0.3	0.5	-0.1	0.7	0.7	0.6
Bone: endosteal perimeter	0.4	0.9	1.7	0.4	1.3	1.3	0.1
Epididymis fat weight	1.0	2.2	2.8	-1.7	-1.6	-1.6	0.8
Delta time in closed arm before/after self-admin	0.9	0.9	2.4	-0.8	-0.5	-0.5	1.6
Delta time in open arm before/after self-admin	0.8	0.8	1.3	0.5	0.9	0.9	-1.2
Diff in mean of infusions in LGA sessions	1.0	1.1	1.4	-1.0	-1.0	-1.0	1.2
Delay discount exponential model param	0.1	0.1	0.2	-0.4	-0.1	-0.1	-0.0
Extinction: sum of active levers before priming	0.9	0.9	1.4	-1.2	-0.8	-0.8	1.1
Active lever presses in extinction session 6	2.5	2.4	3.1	-1.5	-1.7	-1.7	1.1
Bone: final force	1.1	1.7	2.3	1.3	1.5	1.5	-0.9
Bone: final moment	0.9	1.4	1.9	1.1	1.4	1.4	-0.7
Food consumed during 24 hour testing period	0.9	1.1	1.8	-1.1	-0.8	-0.8	1.3
Glucose	0.4	0.5	0.9	0.2	1.0	1.0	0.5
Heart weight	3.9	5.5	7.0	-1.9	-2.4	-2.4	2.6
Delay discount hyperbolic model param	0.1	0.1	0.4	-0.7	-0.2	-0.2	0.1
Intermittent access intake day 1-15 change	0.6	0.6	1.1	-1.1	-0.2	-0.2	1.0
Intermittent access intake escalation	0.4	0.4	0.8	-0.9	0.3	0.3	0.7
Intermittent access intake escalation 2	0.5	0.5	0.9	-0.3	0.9	0.9	0.5
Intermitt. access day 1 inactive lever presses	5.1	5.5	6.4	2.5	2.4	2.4	-2.0
Intermitt. access day 15 inactive lever presses	0.8	0.8	1.2	1.1	1.0	1.0	-0.5
Intermitt. access escalation Index	0.9	0.8	2.1	0.9	0.3	0.3	-1.4
Intermittent access day 1 total infusions	0.5	0.6	0.8	-0.7	-0.9	-0.9	0.5
Intermittent access day 15 total infusions	0.8	0.9	1.4	-1.2	-0.8	-0.8	0.9
Intermittent access terminal intake (last 3 days)	1.1	1.2	1.7	-1.0	-1.0	-1.0	1.3
Intermittent access total infusions	1.1	1.2	2.0	-0.9	-1.1	-1.1	1.4
Intermittent access day 1 locomotion	0.2	0.3	0.8	-0.9	-0.4	-0.4	0.1
Intermittent access day 15 total locomotion	1.3	1.4	4.1	-2.0	-0.7	-0.7	0.8
Intermittent access total locomotion	1.6	1.9	3.4	-1.8	-1.0	-1.0	1.5
Intermittent access standard deviation	0.2	0.2	0.3	0.2	0.6	0.6	-0.4
Left kidney weight	0.2	0.7	1.4	1.2	0.7	0.7	-0.6
Right kidney weight	0.2	0.7	1.3	1.2	0.4	0.4	-1.1
Cocaine induced anxiety	1.4	1.7	1.8	1.3	1.3	1.3	-1.2
Post-drug Anxiety	0.5	0.5	0.7	0.9	0.8	0.8	-0.5
Baseline Anxiety	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.3
Tail length	0.1	0.4	1.3	0.4	0.2	0.2	-1.2
Length with tail	0.0	0.2	0.5	0.7	-0.0	-0.0	-0.3
Length without tail	0.1	0.3	1.0	0.4	-0.2	-0.2	1.0
Times rat made contact with spout	0.3	0.3	0.6	-0.1	-0.8	-0.8	-0.0
Lifetime Intake	1.1	1.2	1.6	-0.6	-1.2	-1.2	1.2
Liver weight, left	0.1	0.1	0.2	0.1	0.4	0.4	0.4
Liver weight, right	0.8	1.4	2.1	0.4	1.5	1.5	-1.0
Locomotor activity	0.2	0.3	0.5	0.2	-0.6	-0.6	0.7
Locomotor testing distance	0.3	0.6	2.1	-0.2	-0.2	-0.2	1.4
Locomotor testing rearing	0.1	0.1	0.2	-0.5	0.3	0.3	0.0
Locomotion in novel chamber	0.1	0.1	0.3	-0.5	-0.2	-0.2	0.3
Locomotion in novel chamber post-restriction	0.3	0.4	0.6	-0.6	-0.8	-0.8	-0.0
Fecal boli incidents, locomotor time 1	0.6	0.6	1.5	-0.4	-0.7	-0.7	1.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.4	-0.7	-0.7	0.1
Time >=10cm from walls, locomotor time 1	3.6	3.6	4.8	1.9	2.2	2.2	-1.3
Bouts of movement, locomotor time 1	0.4	0.5	1.0	0.8	-0.2	-0.2	-1.0
Total resting periods, locomotor time 1	0.4	0.4	0.8	0.7	-0.3	-0.3	-0.9
Rest time, locomotor task time 1	1.2	1.3	1.8	-1.0	-1.3	-1.3	0.8
Distance moved, locomotor task time 1	4.4	4.8	7.7	1.4	2.8	2.8	-1.3
Vertical activity count, locomotor time 1	2.0	2.1	3.2	1.1	1.8	1.8	-0.8
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	0.3	0.1	0.1	-0.0
Bouts of movement, locomotor time 2	0.4	0.4	0.8	0.6	0.5	0.5	-0.9
Total resting periods, locomotor time 2	0.2	0.2	0.3	0.6	0.3	0.3	-0.6
Rest time, locomotor task time 2	0.2	0.2	0.4	0.6	0.5	0.5	-0.3
Distance moved, locomotor task time 2	0.1	0.2	0.3	-0.3	0.4	0.4	-0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.1	0.4	0.4	-0.5
Light reinforcement 1	0.9	1.7	2.9	-0.7	-1.7	-1.7	0.6
Light reinforcement 2	0.0	0.0	0.1	0.1	0.1	0.1	-0.3
Bone: marrow area	0.2	0.4	0.5	-0.1	0.7	0.7	0.6
Bone: maximum diameter	2.7	5.0	8.2	1.6	2.9	2.9	-1.0
Bone: maximum force	2.0	3.5	5.0	1.8	2.2	2.2	-0.9
Bone: maximum moment	1.7	2.9	4.3	1.5	2.1	2.1	-0.7
Mean time between licks in bursts	0.1	0.2	0.5	-0.4	0.0	0.0	-0.7
Mean num. licks in bursts	0.2	0.3	0.5	0.3	0.4	0.4	-0.7
Cd content in liver	0.4	0.5	0.6	-0.8	-0.6	-0.6	0.7
Co content in liver	0.4	0.5	1.9	-0.2	0.2	0.2	1.4
Cu content in liver	0.3	0.4	0.7	0.9	0.6	0.6	-0.3
Fe content in liver	0.1	0.1	0.1	0.1	-0.3	-0.3	0.3
K content in liver	1.5	1.5	2.0	0.9	1.2	1.2	-1.4
Mg content in liver	1.1	1.1	2.7	0.8	0.7	0.8	-1.6
Mn content in liver	1.8	2.0	3.5	1.0	1.3	1.3	-1.9
Na content in liver	1.1	1.1	1.5	-0.6	-1.2	-1.2	-1.0
Rb content in liver	0.1	0.1	0.4	-0.4	-0.0	-0.0	0.6
Se content in liver	1.4	1.7	4.7	1.3	0.3	0.3	-2.2
Sr content in liver	0.1	0.0	0.1	0.4	-0.1	-0.1	-0.1
Zn content in liver	0.2	0.2	0.5	0.4	0.1	0.1	-0.7
Bone: minimum diameter	0.8	1.5	2.8	0.7	1.7	1.7	-0.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.1	0.3	0.3	0.5
Time in novel zone, hab. session 1	0.5	0.5	1.1	0.6	0.6	0.6	-1.0
Total zone transitions, hab. session 1	1.2	1.6	3.0	-1.7	-1.0	-1.0	1.3
Total locomotion distance, hab. session 1	0.1	0.1	0.1	-0.2	0.3	0.3	-0.3
Locomotion velocity, hab. session 1	0.0	0.1	0.2	-0.5	-0.1	-0.1	0.0
Time in familiar zone, hab. session 2	1.6	1.6	2.8	0.9	1.7	1.7	-0.6
Time in novel zone, hab. session 2	1.9	1.9	2.8	-1.0	-1.7	-1.7	1.0
Total zone transitions, hab. session 2	0.1	0.2	0.6	-0.3	-0.1	-0.1	-0.8
Total locomotion distance, hab. session 2	0.8	1.1	2.6	0.5	0.8	0.8	-1.6
Locomotion velocity, hab. session 2	0.5	0.7	1.8	0.4	0.7	0.7	-1.3
Novel to familiar place preference ratio	0.4	0.5	1.3	0.6	0.2	0.2	-1.1
Novelty place preference	0.6	0.6	1.6	0.7	0.3	0.3	-1.3
Time in novel zone, NPP test	0.6	0.6	1.5	0.7	0.4	0.4	-1.2
Total zone transitions, NPP test	1.8	2.5	4.9	-2.2	-1.3	-1.3	1.4
Total locomotion distance, NPP test	0.1	0.2	0.5	-0.3	0.2	0.2	-0.7
Locomotion velocity, NPP test	0.2	0.3	0.7	-0.1	0.4	0.4	-0.8
Intraocular pressure	0.9	1.2	2.5	-1.6	-0.6	-0.6	1.3
Delta distance traveled before/after self-admin	0.9	1.0	1.6	1.2	1.0	1.0	-0.5
Delta ambulatory time before/after self-admin	1.7	1.9	2.9	1.7	1.1	1.1	-1.5
Parametrial fat weight	0.1	0.3	0.4	0.5	0.4	0.4	-0.7
Pavlov. Cond. lever latency	0.2	0.3	0.7	0.8	-0.2	-0.2	-0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.4	0.2	0.2	-0.2
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	-0.4	0.3	0.3	-0.0
Pavlov. Cond. index score	0.1	0.2	0.5	-0.7	0.2	0.2	0.3
Pavlov. Cond. latency score	0.2	0.2	0.7	-0.8	0.1	0.1	0.4
Pavlov. Cond. lever contacts	0.3	0.3	0.5	-0.5	0.7	0.7	-0.1
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	0.2	-0.3	-0.3	0.2
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.6	0.7	0.3	0.3	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	-0.6	0.3	0.3	0.1
Pavlov. Cond. response bias	0.3	0.4	0.6	0.1	0.8	0.8	-0.4
Pavlov. Cond. lever latency	1.4	1.9	3.1	1.2	1.8	1.8	-0.1
Pavlov. Cond. magazine entry latency	0.4	0.4	0.7	-0.6	-0.8	-0.8	-0.0
Pavlov. Cond. change in total contacts	1.5	2.0	2.7	-1.6	-1.6	-1.6	0.2
Pavlov. Cond. index score	1.8	2.3	3.3	-1.6	-1.8	-1.8	0.4
Pavlov. Cond. latency score	1.6	2.0	2.8	-1.6	-1.7	-1.7	0.5
Pavlov. Cond. lever contacts	2.1	2.9	4.7	-1.4	-2.2	-2.2	0.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.5	0.7	0.7	0.7	0.4
Pavlov. Cond. intertrial magazine entries	1.3	1.6	2.2	1.5	1.5	1.5	-0.1
Pavlov. Cond. lever-magazine prob. diff.	2.0	2.5	3.4	-1.7	-1.9	-1.9	0.4
Pavlov. Cond. response bias	1.8	2.4	3.9	-1.4	-2.0	-2.0	0.1
Time in closed arm before self-admin	1.3	1.4	2.8	1.7	0.8	0.8	-1.3
Time in closed arm after self-admin	0.9	0.9	1.1	1.0	1.0	1.0	-0.5
Time in open arm before self-admin	0.3	0.3	0.8	-0.6	-0.2	-0.2	0.9
Time in open arm after self-admin	0.1	0.1	0.2	-0.5	0.1	0.1	0.4
Bone: periosteal estimation	0.8	1.6	2.8	0.8	1.7	1.7	-0.2
Bone: periosteal perimeter	1.1	1.8	3.0	0.9	1.7	1.7	-0.6
Bone: post-yield work	0.5	0.6	0.9	-0.0	0.9	0.9	1.0
Progressive ratio test 1 active lever presses	1.1	1.2	1.7	-1.0	-1.3	-1.3	0.6
Progressive ratio test 1 breakpoint	1.3	1.4	2.1	-0.9	-1.5	-1.5	0.6
Progressive ratio test 1 inactive lever presses	0.2	0.2	0.5	0.4	0.3	0.3	-0.7
Progressive ratio test 2 active lever presses	1.8	2.0	2.0	-1.4	-1.4	-1.4	1.4
Progressive ratio test 2 breakpoint	1.9	2.2	2.6	-1.3	-1.5	-1.5	1.6
Progressive ratio test 2 inactive lever presses	0.2	0.3	0.5	-0.7	-0.3	-0.3	0.7
Incentive Sensitization - Responses	1.3	1.3	2.4	-1.1	-0.9	-0.9	1.5
Incentive Sensitization - Breakpoint	1.4	1.4	2.6	-1.2	-0.9	-0.9	1.6
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	-0.8	-0.6	-0.6	0.7
Progressive ratio	0.2	0.3	0.7	-0.6	-0.2	-0.2	0.8
Food seeking constrained by brief footshock	3.5	4.3	7.0	-1.8	-1.9	-1.9	2.6
Seeking ratio, punishment vs. effort	0.4	0.4	0.5	-0.7	-0.6	-0.6	0.7
Retroperitoneal fat weight	0.1	0.2	0.4	0.0	-0.6	-0.6	-0.2
Reaction time number correct	0.2	0.2	0.4	-0.3	-0.6	-0.6	0.2
Reaction time mean minus median	3.5	4.7	5.8	1.7	2.2	2.2	-2.4
Reaction time mean minus median AUC	4.8	6.2	7.1	2.3	2.5	2.5	-2.7
Reaction time num false alarms	1.2	1.6	3.4	1.8	1.2	1.2	-0.2
Reaction time num false alarms AUC	0.9	1.2	2.0	1.4	1.1	1.1	0.4
Reaction time trials correct on left	0.2	0.2	0.4	-0.3	-0.6	-0.6	0.2
Reaction time trials on left	0.1	0.2	0.3	-0.2	-0.5	-0.5	0.0
Reaction time mean	3.0	4.2	5.1	1.4	2.2	2.2	-2.3
Reaction time mean AUC	4.4	5.9	6.7	1.9	2.6	2.6	-2.6
Median of all reaction times	2.2	3.0	3.6	1.2	1.9	1.9	-1.9
Reaction time omissions	3.0	4.1	7.4	1.8	1.7	1.7	-2.7
Reaction time false alarm rate	0.9	1.2	2.2	1.5	1.2	1.2	0.2
Reaction time premature initiation rate	0.7	0.9	2.9	1.7	-0.1	-0.1	-0.8
Reaction time premature initiations	0.5	0.6	2.0	1.4	-0.2	-0.2	-0.6
Std. dev. reaction times	4.6	6.5	7.7	2.0	2.6	2.6	-2.8
Reaction time trials completed	0.1	0.2	0.3	-0.2	-0.5	-0.5	0.0
Reaction time trials AUC	0.2	0.3	0.5	-0.5	-0.7	-0.7	0.3
Run reversals in cocaine runway, females	0.3	0.3	0.8	0.9	0.3	0.3	-0.5
Run reversals in cocaine runway, males	0.1	0.1	0.2	0.1	0.3	0.3	-0.5
Latency to leave start box in cocaine runway	0.8	0.9	2.0	-0.3	-0.8	-0.8	1.4
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.3	-0.3	-0.3	0.2
Latency to leave start box in cocaine runway, M	0.3	0.3	1.1	-0.2	-0.2	-0.2	1.0
Std. dev. time between licks in bursts	0.7	0.9	1.6	0.6	0.9	0.9	-1.3
Total sessions with >9 infusions	0.3	0.3	0.6	0.1	-0.8	-0.8	0.4
Short access day 1 total inactive lever presses	0.3	0.3	0.9	-0.4	-0.1	-0.1	1.0
Short access day 10 total inactive lever presses	2.1	2.3	2.8	1.7	1.4	1.4	-1.6
Short access day 1 total infusions	0.2	0.2	0.3	0.5	-0.5	-0.5	-0.1
Short access day 10 total infusions	1.7	1.9	2.8	-0.9	-1.7	-1.7	1.1
Short access total infusions	0.3	0.3	0.4	0.5	-0.7	-0.7	0.2
Short access day 1 locomotion	0.8	0.9	1.7	1.2	0.4	0.4	-1.3
Short access day 10 total locomotion	0.8	0.9	1.3	-1.1	-0.9	-0.9	0.9
Short access total locomotion	0.7	0.7	0.9	-0.9	-1.0	-1.0	0.5
One hour access (0.3 mA shock)	0.7	0.8	1.1	-0.6	-1.0	-1.0	1.1
Compulsive drug intake	0.3	0.3	0.4	-0.5	0.6	0.6	-0.4
One hour access (shock baseline)	1.1	1.3	1.9	-0.4	-1.3	-1.3	1.4
Social response proportion	0.1	0.2	0.3	-0.5	0.3	0.3	-0.4
Social responses	0.6	0.7	1.8	0.6	0.6	0.6	-1.3
Social time	0.2	0.2	0.6	0.5	0.3	0.3	-0.8
Soleus weight	10.7	31.4	46.7	-6.3	-4.4	-4.4	6.8
Bone: stiffness	3.9	6.1	8.6	2.2	2.9	2.9	-1.5
Tibialis anterior weight	1.2	4.0	5.7	-2.4	-1.5	-1.5	2.4
Time to tail flick, vehicle, before self-admin	1.3	1.3	2.2	-1.4	-0.7	-0.7	1.5
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	0.0	0.4	0.4	0.4
Time to tail flick, test, before self-admin	3.4	3.4	5.2	-2.3	-1.6	-1.6	1.7
Time to tail flick, test, after self-admin	3.1	3.2	5.5	-2.3	-1.4	-1.4	1.8
Delta time to tail flick, vehicle, before/after SA	0.8	0.8	1.4	1.2	0.6	0.6	-1.1
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.0
Tibia length	0.0	0.1	0.1	-0.0	-0.4	-0.4	0.2
Ambulatory time before self-admin	1.0	1.1	1.3	-1.2	-1.1	-1.1	0.9
Ambulatory time after self-admin	0.1	0.1	0.2	0.5	-0.1	-0.1	-0.3
Bone: tissue strength	0.6	0.6	1.6	-0.8	-0.3	-0.3	1.2
Total heroin consumption	0.5	0.6	0.6	-0.8	-0.8	-0.8	0.8
Bone: trabecular number	0.2	0.3	0.6	-0.3	-0.4	-0.4	0.8
Bone: trabecular spacing	0.1	0.1	0.4	-0.6	-0.0	-0.0	0.3
Bone: trabecular thickness	0.1	0.1	0.3	0.0	-0.2	-0.2	0.5
Bone: trabecular tissue density	1.1	1.5	2.1	1.0	1.2	1.2	-1.4
Water consumed over 24 hours	0.1	0.1	0.1	-0.4	-0.2	-0.2	0.2
Number of responses in last shaping day	1.0	1.0	1.2	-0.7	-1.1	-1.1	1.1