Hub : Genes

Cacna2d1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC alternative TSS NM_001110847.1 0.21 0.12 4.9e-03 0.03 0.04 0.05 0.04 1.5e-02 7.4e-03 2.6e-03 1.3e-02
2 Liver gene expression Cacna2d1 0.16 0.1 5.0e-06 0.05 0.05 0.05 0.04 3.8e-06 1.5e-06 1.4e-06 2.4e-05
3 PL gene expression Cacna2d1 0.82 0.05 3.8e-05 0.03 0.03 0.03 0.03 1.4e-04 4.1e-04 3.7e-04 7.9e-04
4 LHb alternative TSS NM_001110847.1 0.15 0.1 6.6e-03 0.06 0.01 0 0.01 1.7e-02 2.2e-01 2.5e-01 1.6e-01
5 LHb alternative TSS NM_001110847.1 0.15 0.1 9.3e-03 0.05 0.01 -0 0.01 2.9e-02 2.2e-01 3.3e-01 1.8e-01
6 NAcc gene expression Cacna2d1 0.63 0.06 0.0e+00 0.23 0.28 0.25 0.24 3.7e-34 6.6e-42 7.2e-37 3.8e-36
7 NAcc intron excision ratio chr4_19948697_19950353 0.01 0.01 2.5e-03 0.02 0.01 0.02 0.02 4.2e-04 3.0e-03 9.1e-04 1.3e-03
8 IC gene expression Cacna2d1 0.06 0.04 6.1e-03 0.01 0.03 0.01 0.02 7.9e-02 1.4e-02 9.5e-02 7.0e-02
9 IL gene expression Cacna2d1 0.46 0.23 7.2e-06 0.19 0.22 0.14 0.18 2.6e-05 5.6e-06 2.5e-04 4.4e-05
10 IC intron excision ratio chr4_19948697_19950353 0.14 0.09 3.3e-03 0.03 0.06 0.05 0.05 2.6e-02 2.4e-03 3.6e-03 4.2e-03
11 Brain isoform ratio NM_012919.3 0.11 0.09 3.8e-06 0.06 0.06 0.04 0.06 3.2e-06 3.2e-06 5.9e-05 3.0e-06
12 Adipose alternative TSS XM_063285611.1 0.04 0.04 2.7e-03 0.02 0.01 0.01 0.01 1.9e-03 1.8e-02 2.2e-02 7.7e-03
13 Adipose isoform ratio XM_063285611.1 0.05 0.09 2.5e-03 0.02 0.01 0 0.01 3.7e-03 3.0e-02 9.7e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.10.20.8-0.5-0.0-0.2-0.1-0.1-0.5-0.1-0.40.10.10.2-0.9-0.9
Area under the delay curve0.10.10.7-0.4-0.8-0.4-0.4-0.40.3-0.4-0.2-0.2-0.30.0-0.1-0.1
BMI with tail0.10.30.80.60.40.70.90.90.10.20.60.60.8-0.20.20.2
BMI without tail0.10.41.4-0.5-0.90.50.50.50.60.70.71.20.0-0.90.20.2
Body weight0.20.82.00.91.11.11.21.2-0.0-0.3-0.00.31.40.3-1.0-1.0
Weight adjusted by age0.20.30.7-0.3-0.2-0.7-0.8-0.80.40.10.1-0.4-0.7-0.00.80.8
Bone surface0.40.73.11.11.80.80.90.9-0.10.10.20.21.40.1-0.5-0.5
Bone volume0.20.41.60.51.20.20.30.3-0.6-0.5-0.4-0.40.70.6-0.8-0.8
Breakpoint value in progressive ratio session0.50.62.1-1.0-0.4-1.2-1.2-1.2-0.3-0.1-0.5-0.6-1.40.20.30.3
Number of licking bursts0.40.61.2-0.40.4-0.7-0.7-0.7-0.8-1.1-1.0-1.1-0.51.1-0.7-0.7
Context. condit. distance diff. score0.91.03.5-1.7-1.9-0.6-0.4-0.40.60.90.40.7-1.6-0.80.80.8
Locomotion velocity, session 11.81.94.7-0.40.8-1.7-1.6-1.6-1.5-1.7-1.5-2.2-1.11.5-0.4-0.4
Locomotion distance, session 14.25.311.00.32.3-2.2-2.2-2.2-2.9-3.1-2.6-3.3-0.43.0-1.5-1.5
Locomotion velocity, session 20.60.71.70.20.4-1.3-1.3-1.3-0.2-0.3-0.1-1.1-0.80.41.01.0
Locomotion distance, session 21.52.04.21.11.8-1.5-1.6-1.6-1.7-1.9-1.1-2.1-0.31.6-0.0-0.0
Locomotion velocity, session 32.73.16.2-1.8-0.4-2.5-2.3-2.3-2.0-1.6-1.8-1.8-1.91.4-0.4-0.4
Locomotion distance, session 31.51.64.0-1.7-1.0-2.0-1.9-1.9-0.9-0.5-0.7-0.7-1.80.40.30.3
Stereotopy head waving bouts, day 30.70.81.5-0.20.7-1.0-0.9-0.9-1.2-1.2-1.1-1.2-0.41.1-0.5-0.5
Stereotopy head waving duration, day 30.81.03.10.41.5-0.5-0.4-0.4-1.1-1.4-1.3-1.80.01.4-0.5-0.5
Locomotion velocity, session 70.30.40.9-0.30.0-1.0-0.9-0.9-0.4-0.6-0.5-0.7-0.80.50.30.3
Locomotion distance, session 70.81.03.9-2.0-1.6-1.2-1.1-1.1-0.10.1-0.30.2-1.5-0.2-0.1-0.1
Stereotopy head waving bouts, day 72.02.34.2-0.70.4-1.2-1.2-1.2-2.0-1.7-2.0-1.5-0.71.7-2.1-2.1
Stereotopy head waving duration, day 71.82.24.2-0.21.0-0.9-0.9-0.9-2.1-1.8-2.0-1.9-0.31.9-1.7-1.7
Locomotion velocity, session 81.72.04.2-0.50.4-1.6-1.7-1.7-2.1-1.7-1.6-1.7-0.91.6-0.8-0.8
Locomotion distance, session 81.21.75.3-1.5-1.3-1.9-1.7-1.7-0.40.1-0.1-0.6-2.3-0.21.31.3
Degree of sensitization distance1.31.42.90.3-0.81.51.51.51.41.21.21.70.8-1.2-0.1-0.1
Degree of sensitization stereotypy1.01.02.2-0.50.1-0.8-0.8-0.8-1.4-1.1-1.3-0.9-0.51.1-1.5-1.5
Conditioned locomotion0.40.40.80.9-0.10.60.60.60.50.60.90.70.3-0.80.90.9
Cocaine response after cond. corrected1.51.84.2-1.2-1.1-2.0-2.1-2.1-1.2-1.1-1.0-1.1-1.70.9-0.1-0.1
Cocaine response after cond. not corrected0.60.71.9-0.4-0.5-1.2-1.4-1.4-0.9-0.8-0.6-0.7-0.80.6-0.1-0.1
Cocaine response before conditioning1.01.22.91.51.41.61.51.50.50.60.70.71.7-0.4-0.2-0.2
Saline control response0.70.91.80.40.11.41.31.30.80.70.71.21.2-0.7-0.6-0.6
Bone: connectivity density0.10.20.5-0.70.3-0.3-0.2-0.2-0.40.4-0.30.0-0.00.1-0.7-0.7
Bone: cortical apparent density0.91.22.91.21.51.31.21.2-0.1-0.1-0.10.31.70.3-1.4-1.4
Bone: cortical area1.52.36.32.51.52.02.12.10.90.31.31.12.0-0.60.40.4
Bone: cortical porosity0.70.81.71.30.41.31.21.20.60.60.80.61.3-0.60.40.4
Bone: cortical porosity2.72.94.41.90.32.12.12.11.81.61.91.61.8-1.61.31.3
Bone: cortical thickness0.61.02.11.20.01.41.41.40.80.51.11.51.0-0.8-0.0-0.0
Bone: cortical thickness0.60.71.80.80.21.41.31.30.3-0.10.20.81.3-0.1-0.9-0.9
Bone: cortical tissue density0.71.02.51.01.31.21.11.1-0.1-0.1-0.10.31.60.3-1.4-1.4
Condit. Reinf. active minus inactive responses0.91.02.4-0.40.2-1.5-1.5-1.5-1.0-1.1-0.9-1.2-1.01.0-0.1-0.1
Condit. Reinf. active-inactive response ratio0.80.82.3-0.20.3-1.5-1.5-1.5-0.7-0.7-0.6-1.0-0.90.70.20.2
Condit. Reinf. active responses0.81.02.50.00.7-1.0-1.1-1.1-1.1-1.6-1.1-1.2-0.31.3-0.7-0.7
Condit. Reinf. inactive responses0.50.61.30.91.00.60.40.4-0.6-1.1-0.5-0.50.90.9-1.0-1.0
Incentive salience index mean0.81.02.20.20.9-1.1-1.1-1.1-1.1-1.5-1.0-1.3-0.51.3-0.2-0.2
Condit. Reinf. lever presses1.01.43.90.91.70.10.10.1-1.2-2.0-1.2-1.20.71.7-1.3-1.3
Condit. Reinf. active minus inactive responses0.20.30.5-0.5-0.2-0.5-0.3-0.3-0.7-0.5-0.6-0.5-0.50.5-0.7-0.7
Condit. Reinf. active-inactive response ratio0.10.10.20.20.0-0.00.10.1-0.2-0.3-0.2-0.20.00.2-0.5-0.5
Condit. Reinf. active responses0.20.30.9-0.8-0.3-0.7-0.5-0.5-0.6-0.3-0.5-0.5-0.90.4-0.0-0.0
Condit. Reinf. inactive responses0.30.41.4-1.0-0.4-0.6-0.6-0.6-0.30.3-0.1-0.1-1.2-0.20.70.7
Condit. Reinf. lever presses2.94.114.0-3.7-2.0-2.3-2.2-2.2-1.8-0.8-1.8-0.9-3.11.0-0.9-0.9
Condit. Reinf. lever reinforcers received0.40.61.7-1.1-0.5-0.9-0.8-0.8-0.9-0.6-0.8-0.7-1.30.6-0.2-0.2
Conditioned reinforcement - actives0.40.73.3-0.4-0.10.00.00.0-0.7-0.8-0.70.20.40.7-1.8-1.8
Conditioned reinforcement - inactives0.30.51.0-0.7-0.0-0.9-0.9-0.9-0.2-1.0-0.8-0.7-0.50.7-0.7-0.7
Conditioned locomotion0.30.31.7-0.3-0.30.20.20.2-0.4-0.3-0.20.50.40.3-1.3-1.3
Patch foraging indifference point 0 sec0.30.52.8-1.5-1.7-0.3-0.3-0.3-0.00.2-0.10.2-0.9-0.4-0.1-0.1
Patch foraging indifference point AUC0.30.51.11.00.70.00.00.0-1.0-0.8-0.3-0.00.70.6-1.0-1.0
Delay disc. indifference point, 0s delay0.30.30.9-0.7-1.0-0.7-0.7-0.7-0.1-0.1-0.0-0.0-0.6-0.20.40.4
Delay disc. indifference point, 16s delay0.50.52.0-1.0-1.4-0.6-0.5-0.5-0.3-0.5-0.6-0.1-0.50.2-0.9-0.9
Delay disc. indifference point, 2s delay0.30.31.10.60.20.60.60.60.4-0.3-0.10.21.00.1-0.7-0.7
Delay disc. indifference point, 24s delay0.30.41.00.60.8-0.4-0.3-0.3-0.6-1.0-0.6-1.00.20.8-0.3-0.3
Delay disc. indifference point, 4s delay0.20.20.4-0.4-0.7-0.6-0.6-0.60.3-0.3-0.2-0.3-0.30.10.20.2
Delay disc. indifference point, 8s delay0.20.20.6-0.5-0.8-0.6-0.6-0.60.1-0.3-0.3-0.5-0.60.10.20.2
Indifference point function ln k0.10.30.9-0.0-0.00.70.70.70.90.60.30.10.3-0.30.40.4
Indifference point function log k0.10.30.9-0.0-0.00.70.70.70.90.60.30.10.3-0.30.40.4
Patch foraging total patch changes 0 sec0.30.63.5-1.6-1.9-0.4-0.4-0.40.00.2-0.20.3-1.0-0.4-0.3-0.3
Patch foraging total patch changes 12 sec0.30.41.2-0.4-0.6-0.4-0.4-0.4-0.8-0.7-0.6-0.1-0.20.5-1.1-1.1
Patch foraging total patch changes 18 sec1.01.52.9-0.8-0.1-1.4-1.4-1.4-1.7-1.4-1.4-1.1-0.81.2-1.3-1.3
Patch foraging total patch changes 24 sec1.01.84.2-0.6-0.5-1.2-1.2-1.2-2.0-1.6-1.3-0.8-0.31.2-1.9-1.9
Patch foraging total patch changes 6 sec2.33.58.6-2.7-2.1-2.5-2.4-2.4-1.8-0.6-1.3-1.2-2.90.50.10.1
Patch foraging time to switch 0 sec0.40.91.8-1.3-0.4-1.3-1.3-1.3-1.0-0.2-0.8-0.9-1.30.30.20.2
Patch foraging water rate 0 sec0.30.61.20.60.21.01.01.0-0.3-0.7-0.10.41.10.3-1.1-1.1
Patch foraging water rate 12 sec1.12.25.2-0.20.9-0.7-0.7-0.7-2.3-2.2-1.9-1.90.12.0-1.7-1.7
Patch foraging water rate 18 sec1.42.24.4-0.11.5-0.7-0.8-0.8-1.9-2.1-1.9-2.00.22.0-1.5-1.5
Patch foraging water rate 24 sec0.91.33.21.31.41.11.11.1-0.8-1.2-0.5-0.41.80.9-1.2-1.2
Patch foraging water rate 6 sec0.71.02.80.30.70.20.10.1-1.1-1.7-1.0-0.70.71.3-1.5-1.5
Seeking ratio, delayed vs. immediate footshock0.30.31.00.81.00.50.40.40.80.30.4-0.10.20.00.70.7
Distance traveled before self-admin1.41.84.4-1.4-1.9-1.2-1.2-1.2-1.2-0.9-1.2-0.3-0.70.5-2.1-2.1
Distance traveled after self-admin0.70.91.7-1.3-0.9-0.8-0.8-0.8-1.0-0.9-1.0-0.5-0.60.7-1.2-1.2
Extensor digitorum longus weight0.20.91.31.10.81.11.11.10.50.91.00.60.8-0.91.11.1
Bone: elastic displacement0.70.83.6-1.3-1.9-0.5-0.5-0.50.50.90.61.0-1.0-1.00.40.4
Bone: elastic work0.10.10.40.5-0.10.20.20.20.2-0.50.10.30.70.2-0.4-0.4
Bone: endosteal estimation0.51.06.11.52.50.70.70.7-0.3-0.5-0.1-0.91.30.70.30.3
Bone: endosteal perimeter0.81.76.82.32.61.31.41.40.5-0.10.5-0.21.80.30.20.2
Epididymis fat weight0.82.64.9-2.1-0.4-2.0-1.9-1.9-2.2-1.3-1.5-1.8-2.21.20.00.0
Delta time in closed arm before/after self-admin1.51.42.60.21.2-0.6-0.6-0.6-1.3-1.6-1.5-1.50.21.6-1.6-1.6
Delta time in open arm before/after self-admin1.21.22.10.8-0.60.90.90.91.31.51.31.10.8-1.31.11.1
Diff in mean of infusions in LGA sessions0.40.51.3-0.30.7-0.5-0.5-0.5-0.6-0.7-1.0-1.1-0.40.9-0.4-0.4
Delay discount exponential model param0.00.10.30.10.50.20.20.2-0.30.30.20.2-0.0-0.00.10.1
Extinction: sum of active levers before priming1.51.64.00.11.7-1.1-1.1-1.1-1.7-1.6-1.4-2.0-0.51.6-0.1-0.1
Active lever presses in extinction session 61.31.32.7-1.6-0.4-1.1-1.1-1.1-1.5-0.8-1.4-1.2-1.31.0-0.8-0.8
Bone: final force0.60.91.91.10.51.41.31.30.90.31.01.01.1-0.60.70.7
Bone: final moment0.50.81.71.10.71.31.21.20.80.20.90.71.0-0.50.70.7
Food consumed during 24 hour testing period0.60.91.90.11.3-0.6-0.6-0.6-0.9-1.1-1.2-1.40.21.3-0.9-0.9
Glucose0.71.14.31.82.10.80.80.80.1-0.7-0.3-0.71.60.7-0.5-0.5
Heart weight1.21.83.3-0.11.4-0.6-0.5-0.5-1.6-1.7-1.7-1.80.11.8-1.6-1.6
Delay discount hyperbolic model param0.00.10.30.10.60.10.10.1-0.40.30.10.0-0.00.00.10.1
Intermittent access intake day 1-15 change0.71.46.00.70.40.30.30.3-1.0-1.3-0.90.01.31.0-2.5-2.5
Intermittent access intake escalation0.81.66.20.70.60.0-0.0-0.0-1.1-1.6-1.1-0.31.21.3-2.5-2.5
Intermittent access intake escalation 21.31.54.71.91.41.41.41.4-0.1-0.80.00.32.20.4-1.2-1.2
Intermitt. access day 1 inactive lever presses0.93.56.12.40.81.61.61.62.31.42.21.11.6-1.62.52.5
Intermitt. access day 15 inactive lever presses0.10.30.50.60.20.50.50.50.60.60.60.50.7-0.50.30.3
Intermitt. access escalation Index1.01.55.6-0.4-0.9-0.0-0.0-0.00.81.41.10.4-1.0-1.32.42.4
Intermittent access day 1 total infusions0.71.22.6-1.6-1.0-1.5-1.5-1.5-0.7-0.7-0.8-0.7-1.50.6-0.1-0.1
Intermittent access day 15 total infusions1.11.72.5-1.1-0.6-1.6-1.6-1.6-1.3-1.5-1.4-0.9-0.71.2-1.5-1.5
Intermittent access terminal intake (last 3 days)1.41.93.9-0.70.2-1.6-1.6-1.6-1.5-2.0-1.5-1.4-0.51.6-1.2-1.2
Intermittent access total infusions2.22.64.3-1.20.0-2.1-2.1-2.1-1.6-2.0-1.8-1.6-1.01.7-1.3-1.3
Intermittent access day 1 locomotion0.20.20.5-0.30.0-0.7-0.7-0.7-0.5-0.5-0.3-0.5-0.50.50.10.1
Intermittent access day 15 total locomotion0.61.03.0-0.40.2-0.6-0.6-0.6-1.4-1.3-1.1-0.5-0.11.2-1.7-1.7
Intermittent access total locomotion2.12.55.10.11.4-1.2-1.2-1.2-2.0-2.3-1.8-1.80.02.2-1.7-1.7
Intermittent access standard deviation0.40.82.1-1.3-1.4-0.6-0.6-0.6-0.6-0.2-0.50.5-0.40.1-1.5-1.5
Left kidney weight0.20.71.70.0-0.70.91.01.00.91.10.91.30.4-1.10.10.1
Right kidney weight0.31.32.8-0.6-1.30.40.50.51.61.71.41.6-0.3-1.60.70.7
Cocaine induced anxiety0.50.81.90.90.01.11.11.10.90.90.81.01.4-0.90.00.0
Post-drug Anxiety1.11.22.91.70.81.31.31.30.90.81.00.61.4-0.90.70.7
Baseline Anxiety0.10.10.40.30.4-0.0-0.0-0.0-0.2-0.30.0-0.5-0.60.10.60.6
Tail length0.00.10.2-0.2-0.20.50.40.40.30.50.10.3-0.1-0.4-0.0-0.0
Length with tail0.00.20.80.50.90.30.30.30.1-0.3-0.4-0.40.50.3-0.6-0.6
Length without tail0.20.51.30.61.2-0.10.00.0-0.2-0.8-0.8-0.80.70.9-1.0-1.0
Times rat made contact with spout0.50.61.5-0.9-0.2-0.9-0.9-0.9-0.00.2-0.1-0.6-1.2-0.11.11.1
Lifetime Intake2.63.14.8-1.8-0.7-2.2-2.2-2.2-1.5-2.0-1.9-1.3-1.21.7-1.8-1.8
Liver weight, left0.30.52.4-1.5-0.7-0.4-0.3-0.3-0.6-0.2-0.60.2-0.50.3-1.1-1.1
Liver weight, right0.81.33.11.30.11.51.41.40.60.81.01.81.3-0.9-1.0-1.0
Locomotor activity0.20.20.4-0.50.6-0.4-0.5-0.5-0.4-0.4-0.6-0.4-0.30.6-0.6-0.6
Locomotor testing distance0.40.71.90.21.40.40.30.3-0.7-0.8-0.7-0.40.60.9-1.3-1.3
Locomotor testing rearing0.10.20.60.30.50.80.60.6-0.10.30.20.50.4-0.2-0.4-0.4
Locomotion in novel chamber0.20.31.0-0.2-0.30.40.50.5-0.80.5-0.30.4-0.1-0.1-1.0-1.0
Locomotion in novel chamber post-restriction0.30.62.2-1.5-1.0-0.7-0.7-0.7-0.70.2-0.2-0.2-1.3-0.10.40.4
Fecal boli incidents, locomotor time 10.50.81.6-0.40.1-0.7-0.7-0.7-1.1-0.9-1.3-1.1-0.31.0-1.2-1.2
Change in fecal boli incidents, locomotor task0.20.20.7-0.8-0.3-0.2-0.2-0.2-0.5-0.3-0.3-0.0-0.50.3-0.5-0.5
Time >=10cm from walls, locomotor time 13.23.46.32.31.42.52.52.51.71.21.71.32.2-1.21.31.3
Bouts of movement, locomotor time 10.91.02.3-0.8-1.3-0.6-0.6-0.60.81.10.80.6-1.2-1.01.51.5
Total resting periods, locomotor time 10.91.01.9-0.9-1.3-0.6-0.6-0.60.71.20.70.6-1.2-1.01.41.4
Rest time, locomotor task time 10.81.02.5-1.20.2-1.2-1.2-1.2-1.6-0.5-1.0-1.0-1.30.8-0.3-0.3
Distance moved, locomotor task time 12.74.08.32.50.72.92.92.91.51.01.82.12.8-1.3-0.0-0.0
Vertical activity count, locomotor time 10.71.73.71.70.51.81.91.91.10.51.11.31.9-0.80.10.1
Time >=10cm from walls, locomotor time 20.00.00.1-0.20.30.30.30.3-0.3-0.0-0.10.00.20.1-0.1-0.1
Bouts of movement, locomotor time 20.60.94.20.6-0.4-0.2-0.2-0.20.80.71.00.0-0.3-0.82.12.1
Total resting periods, locomotor time 20.40.83.90.6-0.1-0.4-0.3-0.30.60.40.7-0.3-0.3-0.52.02.0
Rest time, locomotor task time 20.20.30.80.30.20.40.40.40.50.70.60.20.3-0.70.90.9
Distance moved, locomotor task time 20.30.41.3-0.1-1.00.50.50.5-0.30.10.31.10.2-0.3-1.0-1.0
Vertical activity count, locomotor time 20.20.31.10.0-1.10.40.40.40.00.60.61.00.0-0.8-0.2-0.2
Light reinforcement 10.41.02.9-1.7-0.5-1.5-1.4-1.4-0.7-0.1-0.9-0.7-1.50.3-0.1-0.1
Light reinforcement 20.10.20.60.3-0.1-0.4-0.5-0.5-0.10.10.3-0.2-0.1-0.30.80.8
Bone: marrow area0.51.16.61.62.60.80.80.8-0.2-0.5-0.1-0.81.40.60.20.2
Bone: maximum diameter2.75.115.33.92.72.82.82.81.40.71.91.23.1-0.80.90.9
Bone: maximum force1.22.14.42.11.42.02.02.01.00.11.31.12.1-0.50.60.6
Bone: maximum moment1.11.94.22.11.51.81.91.90.90.11.20.92.0-0.40.60.6
Mean time between licks in bursts0.20.51.90.60.0-0.0-0.0-0.00.40.50.90.4-0.5-0.71.41.4
Mean num. licks in bursts0.30.41.2-0.0-0.20.10.10.10.60.90.80.5-0.1-0.91.11.1
Cd content in liver0.91.02.0-1.4-0.5-1.2-1.2-1.2-0.8-0.4-1.1-0.7-1.10.6-1.0-1.0
Co content in liver1.01.12.50.81.3-0.5-0.5-0.5-1.2-1.6-1.2-1.60.51.5-0.7-0.7
Cu content in liver0.50.61.10.5-0.51.11.01.00.70.80.70.90.8-0.80.00.0
Fe content in liver0.20.20.8-0.2-0.10.40.40.4-0.1-0.1-0.30.30.70.1-0.9-0.9
K content in liver1.11.12.90.2-0.60.20.20.21.31.11.41.0-0.2-1.41.71.7
Mg content in liver1.01.03.9-1.2-2.0-0.5-0.5-0.50.80.70.91.2-1.1-1.20.80.8
Mn content in liver0.91.03.0-0.4-1.70.30.20.21.10.91.21.7-0.3-1.40.50.5
Na content in liver2.72.98.8-2.2-1.6-2.2-2.3-2.3-0.30.2-0.2-0.6-3.0-0.31.61.6
Rb content in liver0.40.51.20.91.10.20.30.3-0.5-0.9-0.6-0.50.80.8-0.9-0.9
Se content in liver2.63.112.2-2.5-3.5-0.5-0.6-0.61.22.01.22.1-1.9-2.10.70.7
Sr content in liver0.20.20.6-0.2-0.7-0.3-0.3-0.30.50.70.40.4-0.2-0.70.40.4
Zn content in liver0.20.20.5-0.7-0.5-0.3-0.3-0.3-0.6-0.4-0.4-0.2-0.40.3-0.3-0.3
Bone: minimum diameter1.32.36.42.52.31.91.91.90.60.21.00.52.2-0.20.40.4
Time in familiar zone, hab. session 10.40.41.00.90.70.30.30.3-0.4-0.4-0.30.01.00.4-1.0-1.0
Time in novel zone, hab. session 10.70.71.30.1-0.30.80.90.91.01.21.00.8-0.0-1.01.01.0
Total zone transitions, hab. session 11.52.15.6-0.60.0-1.4-1.2-1.2-1.9-1.6-1.5-0.8-0.41.4-2.4-2.4
Total locomotion distance, hab. session 10.30.51.8-0.6-1.00.00.10.1-0.20.40.00.90.1-0.4-1.3-1.3
Locomotion velocity, hab. session 10.40.62.2-0.8-1.0-0.5-0.4-0.4-0.6-0.2-0.40.4-0.20.1-1.5-1.5
Time in familiar zone, hab. session 21.92.15.31.60.72.32.12.10.70.80.91.52.0-0.7-0.7-0.7
Time in novel zone, hab. session 21.91.94.6-1.3-0.2-2.1-2.0-2.0-1.0-1.1-1.2-1.8-1.61.10.20.2
Total zone transitions, hab. session 20.30.41.2-0.7-1.1-0.9-0.8-0.80.20.40.40.6-0.8-0.50.20.2
Total locomotion distance, hab. session 20.71.02.7-0.4-1.40.30.40.40.91.41.31.6-0.2-1.40.60.6
Locomotion velocity, hab. session 20.50.71.9-0.4-1.20.10.20.20.81.21.11.4-0.2-1.20.40.4
Novel to familiar place preference ratio0.91.02.1-0.4-1.4-0.2-0.1-0.11.41.21.00.7-0.7-1.21.51.5
Novelty place preference1.11.22.6-0.3-1.3-0.10.00.01.61.41.10.8-0.7-1.41.61.6
Time in novel zone, NPP test1.01.12.6-0.1-1.10.00.10.11.51.31.10.8-0.5-1.31.61.6
Total zone transitions, NPP test1.42.04.5-0.50.6-1.8-1.6-1.6-2.1-1.6-1.4-1.5-0.81.5-1.1-1.1
Total locomotion distance, NPP test0.30.41.6-1.0-1.2-0.2-0.1-0.1-0.10.50.41.0-0.4-0.6-0.4-0.4
Locomotion velocity, NPP test0.30.41.5-0.8-1.20.10.20.20.10.70.61.2-0.3-0.7-0.3-0.3
Intraocular pressure1.21.74.70.61.8-1.0-1.0-1.0-1.6-1.9-1.3-2.2-0.01.7-0.1-0.1
Delta distance traveled before/after self-admin0.50.51.00.61.01.01.01.00.70.00.40.20.80.00.50.5
Delta ambulatory time before/after self-admin0.30.41.2-0.10.20.50.50.50.80.40.70.50.0-0.41.11.1
Parametrial fat weight0.92.03.40.9-0.31.81.91.91.51.61.71.60.9-1.61.01.0
Pavlov. Cond. lever latency0.50.61.3-1.0-1.2-0.6-0.7-0.70.20.80.40.2-0.9-0.71.01.0
Pavlov. Cond. magazine entry latency0.00.10.20.1-0.10.30.20.20.00.20.10.5-0.2-0.2-0.3-0.3
Pavlov. Cond. change in total contacts0.10.10.30.50.40.40.30.30.2-0.10.10.20.30.1-0.1-0.1
Pavlov. Cond. index score0.20.30.60.80.70.70.60.60.0-0.3-0.10.10.50.3-0.7-0.7
Pavlov. Cond. latency score0.20.30.60.70.80.50.50.5-0.1-0.4-0.2-0.10.50.4-0.6-0.6
Pavlov. Cond. lever contacts0.50.51.51.21.01.01.11.10.4-0.10.20.30.90.0-0.3-0.3
Pavlov. Cond. magazine entry number0.10.10.3-0.30.0-0.5-0.4-0.4-0.3-0.1-0.2-0.6-0.10.20.40.4
Pavlov. Cond. intertrial magazine entries0.81.02.2-0.7-1.20.10.10.10.91.11.10.9-0.6-1.31.51.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.80.60.70.70.70.1-0.20.00.20.50.2-0.6-0.6
Pavlov. Cond. response bias0.40.51.00.60.11.00.90.90.40.10.30.90.7-0.2-0.8-0.8
Pavlov. Cond. lever latency2.02.711.93.42.11.61.71.71.30.31.10.02.4-0.31.01.0
Pavlov. Cond. magazine entry latency0.30.41.5-1.2-1.0-0.7-0.7-0.7-0.50.0-0.20.2-1.0-0.0-0.1-0.1
Pavlov. Cond. change in total contacts1.21.96.2-2.5-1.5-1.6-1.7-1.7-1.3-0.3-0.8-0.3-2.10.4-0.6-0.6
Pavlov. Cond. index score1.62.17.7-2.8-1.6-1.6-1.7-1.7-1.5-0.4-1.1-0.3-2.20.5-0.7-0.7
Pavlov. Cond. latency score1.41.86.2-2.5-1.3-1.4-1.5-1.5-1.5-0.6-1.1-0.3-1.80.6-0.9-0.9
Pavlov. Cond. lever contacts2.33.213.1-3.6-2.2-1.9-2.0-2.0-1.5-0.4-1.2-0.2-2.70.4-0.9-0.9
Pavlov. Cond. magazine entry number0.81.03.41.81.71.11.11.10.6-0.30.1-0.41.50.3-0.0-0.0
Pavlov. Cond. intertrial magazine entries0.91.33.61.71.41.51.51.51.00.60.50.31.9-0.3-0.2-0.2
Pavlov. Cond. lever-magazine prob. diff.1.52.17.2-2.7-1.5-1.6-1.6-1.6-1.5-0.4-1.1-0.3-2.10.4-0.7-0.7
Pavlov. Cond. response bias2.12.810.7-3.3-2.2-1.9-1.9-1.9-1.3-0.2-1.0-0.1-2.60.2-0.6-0.6
Time in closed arm before self-admin0.50.71.6-0.0-1.00.70.70.71.20.91.01.20.4-1.00.60.6
Time in closed arm after self-admin0.50.62.0-0.1-0.70.70.70.70.2-0.2-0.00.80.7-0.0-1.4-1.4
Time in open arm before self-admin0.30.41.10.10.90.40.40.4-0.7-0.5-0.5-0.30.10.7-1.1-1.1
Time in open arm after self-admin0.50.62.11.11.40.80.80.80.20.40.3-0.30.8-0.00.80.8
Bone: periosteal estimation1.02.26.62.62.51.71.71.70.60.10.90.22.0-0.10.80.8
Bone: periosteal perimeter1.22.14.82.21.61.92.02.01.10.51.31.01.9-0.60.50.5
Bone: post-yield work1.31.97.32.02.71.51.61.6-0.0-0.5-0.1-0.32.30.6-0.7-0.7
Progressive ratio test 1 active lever presses1.01.22.2-1.4-0.7-1.5-1.5-1.5-1.0-1.0-1.0-0.6-1.00.9-1.0-1.0
Progressive ratio test 1 breakpoint1.01.22.6-1.6-0.9-1.5-1.5-1.5-0.9-0.8-0.9-0.5-1.10.7-0.9-0.9
Progressive ratio test 1 inactive lever presses0.20.30.5-0.1-0.7-0.5-0.5-0.50.50.40.60.4-0.2-0.60.70.7
Progressive ratio test 2 active lever presses2.22.63.7-1.10.3-1.9-1.9-1.9-1.6-1.9-1.8-1.5-1.01.8-1.6-1.6
Progressive ratio test 2 breakpoint2.32.63.7-1.00.4-1.9-1.9-1.9-1.7-1.9-1.8-1.6-0.91.9-1.6-1.6
Progressive ratio test 2 inactive lever presses0.61.02.5-0.5-0.2-1.6-1.6-1.6-0.8-1.0-0.7-0.9-0.80.8-0.4-0.4
Incentive Sensitization - Responses1.82.54.6-0.11.2-1.4-1.4-1.4-1.7-2.2-1.9-1.8-0.32.1-1.8-1.8
Incentive Sensitization - Breakpoint2.22.95.3-0.01.4-1.5-1.4-1.4-1.9-2.3-2.0-2.0-0.22.3-1.9-1.9
Sum of active levers in priming session hrs 5-62.11.93.5-0.70.9-1.3-1.3-1.3-1.9-1.6-1.8-1.6-0.71.6-1.4-1.4
Progressive ratio0.20.31.71.01.30.60.60.60.1-0.10.1-0.10.70.20.10.1
Food seeking constrained by brief footshock2.93.56.1-0.81.4-1.7-1.8-1.8-2.1-2.3-2.4-2.4-0.42.5-1.8-1.8
Seeking ratio, punishment vs. effort0.91.32.4-1.0-0.5-1.1-1.2-1.2-1.2-1.3-1.3-0.8-0.51.1-1.5-1.5
Retroperitoneal fat weight0.62.45.7-0.5-1.30.50.70.71.52.21.71.4-0.9-2.02.42.4
Reaction time number correct0.30.51.6-1.3-1.1-0.2-0.2-0.2-0.5-0.5-0.60.2-0.60.3-1.0-1.0
Reaction time mean minus median1.33.36.50.9-0.91.92.02.02.22.22.32.51.1-2.11.01.0
Reaction time mean minus median AUC1.64.17.41.3-0.72.12.22.22.62.52.52.71.3-2.31.31.3
Reaction time num false alarms0.50.71.91.40.71.01.01.01.10.30.60.61.4-0.2-0.1-0.1
Reaction time num false alarms AUC0.71.03.51.91.51.01.01.00.6-0.20.10.01.80.4-0.6-0.6
Reaction time trials correct on left0.30.51.6-1.3-1.1-0.2-0.2-0.2-0.5-0.5-0.60.2-0.60.3-1.0-1.0
Reaction time trials on left0.20.41.6-1.3-1.2-0.2-0.1-0.1-0.4-0.4-0.50.3-0.60.2-0.9-0.9
Reaction time mean2.33.65.71.0-0.62.02.12.12.42.32.42.41.2-2.21.51.5
Reaction time mean AUC3.04.77.41.3-0.52.42.52.52.72.62.72.71.5-2.41.61.6
Median of all reaction times2.02.84.31.0-0.31.82.02.02.12.02.02.01.2-1.91.31.3
Reaction time omissions2.43.67.10.2-1.41.01.21.22.42.62.62.7-0.1-2.52.02.0
Reaction time false alarm rate0.71.04.32.11.70.80.80.80.80.10.4-0.21.60.20.20.2
Reaction time premature initiation rate0.50.83.2-1.6-1.8-0.5-0.5-0.51.00.20.30.6-0.9-0.50.50.5
Reaction time premature initiations0.50.84.4-1.9-2.1-0.5-0.5-0.50.7-0.00.10.7-1.0-0.40.00.0
Std. dev. reaction times2.75.08.71.3-0.92.32.42.42.82.62.93.01.3-2.61.71.7
Reaction time trials completed0.20.41.6-1.3-1.2-0.2-0.1-0.1-0.4-0.4-0.50.3-0.60.2-0.9-0.9
Reaction time trials AUC0.30.61.8-1.3-1.1-0.3-0.2-0.2-0.6-0.6-0.70.1-0.70.3-1.1-1.1
Run reversals in cocaine runway, females0.10.10.4-0.1-0.6-0.6-0.6-0.60.10.2-0.0-0.3-0.2-0.10.10.1
Run reversals in cocaine runway, males0.10.10.4-0.1-0.60.10.10.10.10.50.40.5-0.1-0.50.40.4
Latency to leave start box in cocaine runway0.91.02.3-0.80.1-0.6-0.5-0.5-1.3-1.1-1.3-0.8-0.31.2-1.5-1.5
Latency to leave start box in cocaine runway, F0.91.13.5-1.5-1.5-0.4-0.4-0.4-0.8-0.5-0.90.3-0.50.4-1.9-1.9
Latency to leave start box in cocaine runway, M0.90.83.70.81.9-0.1-0.1-0.1-1.0-1.0-0.8-1.40.41.2-0.2-0.2
Std. dev. time between licks in bursts1.01.42.90.7-0.01.01.01.01.21.41.51.10.1-1.41.71.7
Total sessions with >9 infusions1.41.74.2-2.0-1.0-1.7-1.7-1.7-0.7-1.1-1.2-0.6-1.40.9-1.1-1.1
Short access day 1 total inactive lever presses1.01.33.1-0.7-0.2-0.8-0.8-0.8-1.1-1.5-1.3-0.9-0.31.3-1.8-1.8
Short access day 10 total inactive lever presses0.71.62.90.5-1.01.11.11.11.51.31.71.60.3-1.61.31.3
Short access day 1 total infusions1.31.76.6-2.6-2.3-1.1-1.1-1.1-0.4-0.7-0.70.3-1.50.3-1.3-1.3
Short access day 10 total infusions2.83.55.6-2.4-1.2-2.3-2.3-2.3-1.6-1.8-2.0-1.2-1.71.6-1.9-1.9
Short access total infusions2.12.66.1-2.5-1.5-1.9-1.9-1.9-1.0-1.3-1.5-0.5-1.61.1-1.7-1.7
Short access day 1 locomotion0.91.15.0-1.5-2.2-0.6-0.6-0.60.90.90.71.1-1.0-1.00.50.5
Short access day 10 total locomotion0.51.02.1-1.1-0.8-1.0-1.0-1.0-1.0-0.8-0.9-0.3-0.70.8-1.4-1.4
Short access total locomotion1.21.42.4-1.4-0.7-1.6-1.5-1.5-1.0-1.0-1.1-0.6-1.01.0-1.3-1.3
One hour access (0.3 mA shock)1.41.63.1-1.1-0.1-1.5-1.5-1.5-1.1-1.8-1.4-1.2-1.01.4-1.1-1.1
Compulsive drug intake0.00.10.20.3-0.40.00.00.0-0.3-0.20.10.40.0-0.1-0.3-0.3
One hour access (shock baseline)1.11.62.5-1.00.3-1.6-1.6-1.6-1.0-1.6-1.5-1.5-0.91.5-0.9-0.9
Social response proportion0.10.20.4-0.4-0.60.10.20.20.10.70.50.6-0.3-0.60.20.2
Social responses0.81.03.1-1.0-1.80.30.40.40.71.31.11.6-0.5-1.40.30.3
Social time0.71.04.4-1.8-2.10.40.30.30.11.10.31.3-0.5-0.9-0.7-0.7
Soleus weight8.525.046.30.35.0-3.4-3.3-3.3-6.4-6.7-6.2-6.7-0.46.8-5.0-5.0
Bone: stiffness2.74.47.32.71.72.72.72.71.71.02.11.52.6-1.31.81.8
Tibialis anterior weight0.82.95.5-0.11.6-1.0-0.9-0.9-2.3-2.1-2.2-2.0-0.02.1-2.1-2.1
Time to tail flick, vehicle, before self-admin0.90.92.80.91.7-0.0-0.0-0.0-0.9-1.0-0.9-0.70.81.1-1.3-1.3
Time to tail flick, vehicle, after self-admin1.01.33.71.51.11.01.01.0-0.0-0.8-0.40.01.90.7-1.6-1.6
Time to tail flick, test, before self-admin1.01.11.80.00.8-1.2-1.2-1.2-1.3-1.3-1.0-1.3-0.51.3-0.4-0.4
Time to tail flick, test, after self-admin2.42.55.70.61.6-0.9-0.9-0.9-2.1-2.4-1.8-2.20.22.3-1.1-1.1
Delta time to tail flick, vehicle, before/after SA0.30.30.90.0-0.60.30.30.30.80.30.60.30.1-0.51.01.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.2-0.2-0.1-0.1-0.1-0.3-0.5-0.4-0.4-0.00.3-0.3-0.3
Tibia length0.00.00.2-0.0-0.1-0.1-0.1-0.1-0.1-0.3-0.3-0.0-0.10.1-0.4-0.4
Ambulatory time before self-admin0.81.25.5-1.4-2.3-0.9-0.9-0.9-0.6-0.3-0.60.3-0.6-0.0-1.4-1.4
Ambulatory time after self-admin0.30.41.7-1.1-1.3-0.4-0.4-0.4-0.3-0.3-0.40.0-0.30.1-0.7-0.7
Bone: tissue strength0.60.61.80.81.30.00.10.1-0.6-0.9-0.7-0.70.61.0-0.9-0.9
Total heroin consumption1.11.32.2-0.90.4-1.5-1.5-1.5-1.3-1.3-1.2-1.4-1.21.1-0.3-0.3
Bone: trabecular number0.30.41.8-0.60.0-0.4-0.3-0.3-0.7-0.3-0.7-0.10.10.5-1.3-1.3
Bone: trabecular spacing0.40.51.50.81.20.20.30.30.3-0.60.1-0.80.30.51.21.2
Bone: trabecular thickness0.10.10.4-0.10.20.1-0.1-0.1-0.6-0.2-0.4-0.4-0.00.3-0.2-0.2
Bone: trabecular tissue density0.71.02.30.4-0.90.80.90.91.11.51.21.40.1-1.40.80.8
Water consumed over 24 hours0.10.20.40.00.4-0.4-0.4-0.4-0.30.1-0.1-0.6-0.20.10.60.6
Number of responses in last shaping day2.02.23.5-0.80.5-1.9-1.9-1.9-1.5-1.8-1.7-1.7-1.01.7-1.1-1.1