Cacna1i

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	Cacna1i	0.14	0.06	1.7e-16	0.14	0.14	0.14	0.14	6.0e-15	7.4e-15	2.5e-15	3.8e-15
2	IL	gene expression	Cacna1i	0.4	0.14	2.7e-06	0.1	0.17	0.07	0.12	1.9e-03	7.4e-05	9.6e-03	8.7e-04
3	Adipose	gene expression	Cacna1i	0.63	0.1	0.0e+00	0.5	0.55	0.57	0.54	6.3e-63	4.1e-73	6.8e-78	1.3e-70
4	Adipose	isoform ratio	XM_039079798.1	0.06	0.04	2.9e-04	0.02	0.02	0.02	0	9.4e-04	4.0e-03	1.3e-03	7.5e-02
5	IL	mRNA stability	Cacna1i	0.26	0.14	2.6e-03	0.09	0.06	0.05	0.07	4.6e-03	1.9e-02	2.1e-02	1.1e-02
6	Brain	isoform ratio	XM_039079796.1	0.06	0.03	6.0e-05	0.06	0.05	0.04	0.04	7.1e-06	2.7e-05	4.7e-05	5.8e-05
7	Brain	gene expression	Cacna1i	0.29	0.09	0.0e+00	0.26	0.27	0.29	0.29	1.3e-23	2.7e-25	4.9e-27	1.6e-27
8	Adipose	mRNA stability	Cacna1i	0.03	0.02	1.4e-03	0.03	0.02	0.02	0.02	3.7e-04	8.9e-04	1.1e-03	1.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8
Bone: apparent density	0.1	0.2	0.5	-0.3	0.3	-0.6	0.7	-0.4	-0.6	0.1	0.2
Area under the delay curve	1.6	1.7	3.9	-0.9	0.7	-2.0	1.7	-1.8	-1.3	-0.5	0.6
BMI with tail	0.5	1.7	4.0	2.0	-1.7	1.1	-1.0	1.6	0.8	-0.8	0.4
BMI without tail	0.1	0.2	0.7	0.0	0.1	0.0	0.6	0.7	-0.5	0.8	-0.3
Body weight	1.3	5.4	10.3	3.2	-2.9	2.1	-2.3	2.3	2.1	-1.8	1.0
Weight adjusted by age	0.3	0.3	0.6	-0.4	0.6	0.4	-0.7	0.4	0.5	0.4	-0.8
Bone surface	0.1	0.2	0.6	-0.1	0.0	-0.8	0.4	-0.5	-0.2	-0.8	0.3
Bone volume	0.0	0.0	0.2	0.1	-0.1	-0.3	0.1	-0.1	0.1	-0.5	-0.2
Breakpoint value in progressive ratio session	0.2	0.2	0.5	-0.1	0.1	-0.7	0.7	-0.4	-0.7	0.2	0.1
Number of licking bursts	0.8	0.9	1.6	-1.0	1.2	-0.9	0.6	-1.3	-0.9	0.1	-1.0
Context. condit. distance diff. score	5.5	6.6	12.3	2.4	-1.8	3.5	-3.0	3.2	3.0	-0.1	-1.6
Locomotion velocity, session 1	0.6	0.6	2.3	0.2	-0.4	-0.9	0.5	-0.9	-0.4	-1.5	0.7
Locomotion distance, session 1	2.3	3.0	6.8	-1.7	1.5	-2.4	1.7	-2.6	-1.7	-0.5	-0.4
Locomotion velocity, session 2	0.2	0.3	0.6	0.7	-0.8	0.0	-0.3	0.4	0.2	-0.8	0.4
Locomotion distance, session 2	3.4	4.7	10.3	-1.5	1.0	-3.2	2.7	-3.0	-2.6	-0.7	0.9
Locomotion velocity, session 3	1.6	1.9	4.0	0.3	0.1	1.7	-2.0	1.4	2.0	0.2	-1.4
Locomotion distance, session 3	1.2	1.3	3.3	-1.5	1.8	0.2	-0.5	-0.6	0.4	0.7	-1.8
Stereotopy head waving bouts, day 3	0.9	1.0	2.3	1.4	-1.5	0.1	-0.2	0.5	0.2	-1.4	1.2
Stereotopy head waving duration, day 3	2.4	2.9	6.2	2.4	-2.5	1.0	-1.1	1.6	1.0	-1.7	1.6
Locomotion velocity, session 7	0.8	0.9	2.1	0.7	-0.7	1.2	-1.5	0.9	1.4	-0.3	-0.4
Locomotion distance, session 7	0.3	0.3	1.1	0.3	-0.5	-0.3	0.2	-0.6	-0.1	-1.0	0.8
Stereotopy head waving bouts, day 7	2.9	3.2	5.9	1.5	-1.4	2.2	-2.4	2.4	2.1	-0.4	-0.8
Stereotopy head waving duration, day 7	3.0	3.6	7.5	1.1	-0.9	2.5	-2.4	2.7	2.2	0.5	-1.5
Locomotion velocity, session 8	1.3	1.6	3.3	1.8	-1.7	1.0	-1.1	0.8	1.0	-1.5	0.3
Locomotion distance, session 8	0.6	0.8	1.3	0.6	-0.4	1.1	-0.9	1.1	1.1	0.4	-1.1
Degree of sensitization distance	2.2	2.2	5.9	2.1	-2.4	0.4	0.0	0.8	0.0	-1.2	2.2
Degree of sensitization stereotypy	2.6	2.8	5.1	1.0	-0.7	2.3	-2.2	2.2	2.0	0.2	-1.4
Conditioned locomotion	0.2	0.3	0.6	0.5	-0.5	0.8	-0.6	0.5	0.6	0.1	0.3
Cocaine response after cond. corrected	0.3	0.4	2.0	0.6	-0.6	-0.3	0.2	0.0	-0.2	-0.5	1.4
Cocaine response after cond. not corrected	0.2	0.2	1.1	0.3	-0.4	-0.2	0.2	0.3	-0.1	0.0	1.0
Cocaine response before conditioning	0.3	0.4	1.1	-0.8	0.7	0.2	-0.1	0.3	0.2	0.9	-1.0
Saline control response	0.7	0.9	2.8	-0.9	0.9	0.9	-0.7	0.6	0.6	1.7	-0.8
Bone: connectivity density	0.1	0.1	0.3	0.1	-0.0	-0.4	0.4	-0.3	-0.3	-0.2	0.6
Bone: cortical apparent density	0.6	0.8	3.0	-1.0	1.4	0.3	-0.6	-0.2	0.5	0.5	-1.7
Bone: cortical area	1.1	1.6	3.7	1.9	-1.8	0.4	-0.6	0.6	0.5	-1.8	1.2
Bone: cortical porosity	1.0	1.1	2.8	1.3	-1.5	0.7	-0.5	1.2	0.4	-0.1	1.7
Bone: cortical porosity	1.8	2.0	4.8	1.9	-2.1	0.7	-0.7	1.3	0.5	-0.7	2.2
Bone: cortical thickness	0.3	0.4	1.1	0.8	-0.7	-0.3	0.1	-0.3	-0.3	-1.1	0.9
Bone: cortical thickness	0.7	0.8	1.9	0.7	-0.5	-0.9	0.7	-1.1	-0.8	-1.4	0.5
Bone: cortical tissue density	0.6	0.8	2.7	-1.0	1.3	0.3	-0.6	-0.1	0.6	0.4	-1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	-0.4	0.3	-0.6	0.1	-0.3	-0.2	-0.4	-0.1
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.6	0.2	0.0	0.6	-0.7	0.7	0.8	-0.2	-0.5
Condit. Reinf. active responses	0.9	1.1	2.4	-1.6	1.4	-1.1	0.8	-0.9	-0.9	0.7	-0.7
Condit. Reinf. inactive responses	2.1	2.5	4.7	-2.2	2.0	-1.3	1.3	-1.4	-1.5	1.6	-1.2
Incentive salience index mean	0.3	0.3	0.7	-0.7	0.6	-0.8	0.6	-0.5	-0.5	-0.1	-0.1
Condit. Reinf. lever presses	0.3	0.4	0.9	-0.9	0.7	-0.9	0.8	-0.5	-0.7	0.2	-0.2
Condit. Reinf. active minus inactive responses	0.7	0.8	2.0	0.1	-0.4	-1.2	0.7	-1.1	-0.6	-1.4	0.8
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.2	0.5	-0.9	-0.9	0.6	-0.6	-0.4	-1.5	1.3
Condit. Reinf. active responses	0.5	0.6	2.6	0.7	-1.0	-0.5	-0.1	-0.3	0.2	-1.6	0.8
Condit. Reinf. inactive responses	0.4	0.5	1.4	0.8	-0.7	0.3	-0.9	0.3	0.8	-1.2	0.1
Condit. Reinf. lever presses	0.4	0.5	1.1	-0.8	0.5	-1.0	0.9	-0.6	-0.8	0.1	-0.5
Condit. Reinf. lever reinforcers received	0.4	0.5	1.8	0.5	-0.9	-0.7	0.0	-0.3	0.1	-1.3	0.8
Conditioned reinforcement - actives	0.4	0.4	0.9	-0.3	0.3	-0.7	0.4	-1.0	-0.5	-0.8	0.7
Conditioned reinforcement - inactives	1.7	1.9	3.4	-0.7	0.5	-1.8	1.8	-1.8	-1.8	-0.5	0.8
Conditioned locomotion	1.2	1.5	3.9	1.2	-1.3	-0.7	0.5	-0.6	-0.5	-2.0	1.8
Patch foraging indifference point 0 sec	0.4	0.7	1.3	-0.6	0.5	-0.9	1.1	-0.8	-1.1	0.4	0.6
Patch foraging indifference point AUC	1.2	1.3	3.5	-0.6	0.6	-1.4	1.2	-1.9	-1.0	-1.3	0.5
Delay disc. indifference point, 0s delay	0.5	0.5	1.5	1.0	-1.2	-0.1	0.3	0.3	0.0	-0.5	1.2
Delay disc. indifference point, 16s delay	2.9	2.9	6.2	-1.6	1.3	-2.5	2.0	-2.3	-1.8	-0.1	0.7
Delay disc. indifference point, 2s delay	0.6	0.6	1.6	0.0	-0.2	-1.2	0.7	-1.0	-0.9	-0.8	0.8
Delay disc. indifference point, 24s delay	1.2	1.1	3.0	-0.3	0.3	-1.4	1.0	-1.7	-0.5	-1.5	0.6
Delay disc. indifference point, 4s delay	1.2	1.3	2.7	-0.2	-0.0	-1.7	1.3	-1.6	-1.2	-0.9	0.9
Delay disc. indifference point, 8s delay	2.0	2.0	3.9	-1.2	1.1	-1.9	2.0	-1.8	-1.6	-0.1	0.4
Indifference point function ln k	2.1	2.9	6.3	1.3	-1.2	2.2	-2.0	2.5	2.1	0.6	-0.5
Indifference point function log k	2.1	2.9	6.3	1.3	-1.2	2.2	-2.0	2.5	2.1	0.6	-0.5
Patch foraging total patch changes 0 sec	0.6	1.0	2.1	-0.8	0.7	-1.2	1.4	-1.0	-1.4	0.6	0.4
Patch foraging total patch changes 12 sec	0.5	0.6	2.4	0.0	-0.3	-0.8	0.7	-0.7	-0.6	-0.7	1.6
Patch foraging total patch changes 18 sec	1.8	2.3	4.0	0.0	-0.3	-1.8	2.0	-1.7	-1.9	-1.3	1.7
Patch foraging total patch changes 24 sec	0.7	0.8	1.6	-0.7	0.5	-1.1	1.3	-1.2	-1.1	-0.2	0.1
Patch foraging total patch changes 6 sec	1.8	2.6	5.6	-0.5	0.4	-2.0	1.9	-2.4	-2.2	-0.9	1.3
Patch foraging time to switch 0 sec	0.3	0.5	2.2	0.5	-0.9	0.2	-0.3	0.9	0.1	0.2	1.5
Patch foraging water rate 0 sec	0.3	0.5	1.3	-0.3	0.6	-0.6	1.1	-1.1	-0.9	0.0	-0.5
Patch foraging water rate 12 sec	0.4	0.6	1.7	-1.0	1.1	-0.0	0.3	-0.1	-0.1	1.1	-1.3
Patch foraging water rate 18 sec	0.8	1.1	1.9	-1.2	1.1	-1.0	1.1	-1.4	-1.3	0.4	-0.4
Patch foraging water rate 24 sec	0.2	0.2	0.7	0.3	-0.3	0.7	-0.5	0.8	0.5	0.2	-0.2
Patch foraging water rate 6 sec	0.9	1.3	3.4	-1.7	1.8	-0.0	0.3	-0.2	-0.1	1.6	-1.3
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	1.1	-1.0	1.0	-0.6	0.5	-0.5	-0.4	0.9	-0.7
Distance traveled before self-admin	0.5	0.5	1.2	-0.3	0.0	-1.0	0.9	-0.5	-1.0	-0.1	1.1
Distance traveled after self-admin	2.0	2.2	7.3	0.4	-0.6	-1.5	1.4	-1.5	-1.6	-1.1	2.7
Extensor digitorum longus weight	0.4	1.6	3.4	-1.3	1.3	-1.0	1.9	-0.6	-1.5	1.4	-0.3
Bone: elastic displacement	0.0	0.0	0.1	0.1	-0.1	0.3	-0.3	0.2	0.3	0.1	0.1
Bone: elastic work	1.4	1.8	4.8	2.0	-2.2	0.4	-0.4	0.9	0.4	-1.3	1.7
Bone: endosteal estimation	0.7	1.5	3.7	1.7	-1.9	0.4	-0.8	0.8	0.8	-1.5	0.8
Bone: endosteal perimeter	1.3	2.7	5.0	2.1	-2.2	1.3	-1.6	1.8	1.6	-1.2	0.7
Epididymis fat weight	3.5	8.3	14.2	3.1	-2.6	3.4	-3.8	3.3	3.3	-1.3	-0.1
Delta time in closed arm before/after self-admin	0.8	0.8	1.4	1.1	-1.1	0.6	-0.7	0.6	0.9	-1.2	0.6
Delta time in open arm before/after self-admin	0.4	0.4	0.8	-0.7	0.7	-0.7	0.7	-0.4	-0.9	0.6	0.2
Diff in mean of infusions in LGA sessions	0.4	0.4	1.0	0.1	-0.1	-0.7	0.4	-1.0	-0.7	-1.0	0.3
Delay discount exponential model param	1.7	1.8	4.0	1.0	-0.8	2.0	-1.7	1.9	1.3	0.5	-0.5
Extinction: sum of active levers before priming	0.3	0.3	1.0	-0.2	0.1	-1.0	0.3	-0.8	-0.4	-0.3	0.1
Active lever presses in extinction session 6	0.1	0.1	0.3	0.4	-0.5	-0.1	-0.1	-0.0	-0.1	-0.4	0.4
Bone: final force	1.5	2.5	6.3	2.3	-2.4	-0.0	-0.2	0.2	0.2	-2.5	1.6
Bone: final moment	1.7	2.7	7.0	2.3	-2.5	-0.1	-0.0	0.1	0.1	-2.7	1.7
Food consumed during 24 hour testing period	1.1	1.3	3.5	1.9	-1.8	0.4	-0.3	0.5	0.2	-1.6	0.7
Glucose	0.1	0.2	0.8	-0.3	-0.1	-0.4	0.2	0.1	-0.3	0.7	0.9
Heart weight	0.5	0.7	2.3	1.5	-1.3	1.0	-0.3	0.7	0.2	-0.3	0.2
Delay discount hyperbolic model param	1.6	1.7	3.9	0.9	-0.6	2.0	-1.7	1.8	1.3	0.6	-0.6
Intermittent access intake day 1-15 change	0.6	0.6	1.6	-1.2	1.3	-0.4	0.4	-0.6	-0.6	0.9	-0.2
Intermittent access intake escalation	0.6	0.6	1.4	-1.1	1.2	-0.5	0.4	-0.5	-0.6	0.9	-0.3
Intermittent access intake escalation 2	0.4	0.4	0.7	-0.9	0.9	-0.4	0.5	-0.5	-0.8	0.8	-0.2
Intermitt. access day 1 inactive lever presses	0.7	0.8	2.3	0.4	-0.7	-0.8	1.1	-0.3	-0.7	-0.6	1.5
Intermitt. access day 15 inactive lever presses	0.5	0.6	1.4	0.4	-0.5	-0.7	0.5	-0.8	-0.6	-1.2	1.1
Intermitt. access escalation Index	0.3	0.2	0.4	-0.6	0.5	-0.3	0.6	-0.3	-0.5	0.3	-0.6
Intermittent access day 1 total infusions	1.0	1.1	3.2	1.2	-1.3	-0.6	0.3	-0.4	-0.3	-1.8	1.5
Intermittent access day 15 total infusions	0.7	0.8	1.4	-0.0	-0.1	-1.2	1.0	-1.0	-0.9	-0.8	1.1
Intermittent access terminal intake (last 3 days)	0.3	0.3	0.6	-0.1	0.1	-0.7	0.6	-0.8	-0.7	-0.5	0.6
Intermittent access total infusions	1.0	1.1	2.3	0.8	-0.9	-1.0	0.8	-0.8	-0.7	-1.5	1.5
Intermittent access day 1 locomotion	0.8	0.9	2.0	0.9	-1.0	-0.7	0.8	-0.4	-0.7	-1.3	1.4
Intermittent access day 15 total locomotion	0.4	0.4	1.5	1.0	-0.9	-0.1	0.1	-0.1	0.0	-1.2	0.6
Intermittent access total locomotion	1.2	1.3	3.2	1.5	-1.4	-0.3	0.4	-0.3	-0.4	-1.8	1.6
Intermittent access standard deviation	0.8	0.9	5.0	0.7	-1.0	-0.5	0.3	0.1	-0.3	-0.5	2.2
Left kidney weight	8.0	22.6	37.2	6.1	-5.7	4.5	-5.0	4.4	5.2	-4.2	1.7
Right kidney weight	8.0	22.3	42.4	6.5	-6.1	4.0	-4.5	3.8	4.5	-4.7	2.7
Cocaine induced anxiety	1.1	1.3	2.9	1.7	-1.5	1.2	-1.0	1.2	1.0	-0.6	-0.3
Post-drug Anxiety	0.6	0.6	1.5	1.2	-1.1	0.8	-0.7	0.8	0.6	-0.5	-0.2
Baseline Anxiety	0.8	0.8	1.6	-1.3	1.2	-0.8	0.8	-0.8	-0.9	0.4	-0.6
Tail length	0.0	0.1	0.6	-0.3	0.4	0.3	0.2	0.3	-0.1	0.8	-0.2
Length with tail	0.6	2.4	3.7	1.8	-1.6	1.6	-1.9	1.4	1.9	-1.1	0.5
Length without tail	1.9	4.1	6.7	2.4	-2.3	1.6	-2.6	1.2	2.2	-2.2	1.0
Times rat made contact with spout	0.3	0.4	1.3	0.6	-0.1	-0.2	0.4	-0.9	-0.4	-1.1	-0.6
Lifetime Intake	1.5	1.6	3.9	1.3	-1.5	-0.8	0.6	-0.6	-0.5	-2.0	1.9
Liver weight, left	1.2	2.0	3.5	1.1	-0.8	1.9	-1.8	1.9	1.9	-0.1	-0.1
Liver weight, right	4.2	7.0	13.4	1.7	-1.3	3.6	-3.7	3.5	3.5	0.4	-0.6
Locomotor activity	1.0	1.5	2.6	1.6	-1.5	1.3	-1.0	1.5	1.2	-0.9	0.6
Locomotor testing distance	0.1	0.1	0.5	-0.2	0.4	0.4	0.0	0.4	0.3	0.2	-0.7
Locomotor testing rearing	1.0	1.5	2.6	1.5	-1.3	1.4	-1.2	1.6	1.3	-0.7	0.6
Locomotion in novel chamber	3.6	4.4	9.5	-2.9	3.1	-0.3	0.6	-0.4	-0.7	3.0	-2.7
Locomotion in novel chamber post-restriction	0.5	0.6	1.2	-1.1	1.0	-0.5	0.2	-0.3	-0.3	0.8	-1.1
Fecal boli incidents, locomotor time 1	1.7	1.9	3.1	-0.1	-0.1	-1.6	1.8	-1.7	-1.7	-1.1	1.6
Change in fecal boli incidents, locomotor task	1.2	1.1	2.9	0.1	0.0	1.3	-1.6	0.8	1.7	-0.4	-0.9
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.2	1.1	-1.2	-0.1	-0.2	0.1	-0.1	-1.3	1.5
Bouts of movement, locomotor time 1	0.9	1.0	1.6	1.2	-1.1	1.0	-1.0	0.7	1.3	-1.1	0.1
Total resting periods, locomotor time 1	0.5	0.6	1.3	1.0	-1.1	0.5	-0.4	0.4	0.7	-1.2	0.5
Rest time, locomotor task time 1	0.7	0.8	1.7	1.1	-1.2	0.1	0.4	0.1	-0.0	-1.3	1.3
Distance moved, locomotor task time 1	0.7	0.8	1.6	0.1	0.0	1.0	-1.3	1.2	1.0	0.8	-0.9
Vertical activity count, locomotor time 1	0.1	0.1	0.3	-0.0	0.2	0.2	-0.1	-0.1	-0.2	0.5	-0.3
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.7	0.2	-0.2	-0.4	0.5	-0.5	-0.5	-0.4	0.8
Bouts of movement, locomotor time 2	0.5	0.6	1.0	0.7	-0.6	0.8	-1.0	1.0	1.0	-0.2	-0.5
Total resting periods, locomotor time 2	0.3	0.3	0.4	0.6	-0.6	0.4	-0.6	0.6	0.6	-0.5	-0.2
Rest time, locomotor task time 2	0.3	0.4	0.6	-0.1	-0.0	-0.8	0.6	-0.8	-0.6	-0.8	0.8
Distance moved, locomotor task time 2	0.7	0.8	1.6	0.6	-0.4	1.2	-1.1	1.3	1.0	0.5	-0.3
Vertical activity count, locomotor time 2	0.2	0.3	0.7	0.8	-0.7	0.7	-0.4	0.3	0.3	-0.2	0.3
Light reinforcement 1	0.0	0.1	0.2	-0.4	0.1	-0.4	0.4	-0.2	-0.1	-0.2	0.2
Light reinforcement 2	1.3	1.7	4.0	0.5	-0.6	1.6	-1.6	2.0	1.9	0.5	-0.4
Bone: marrow area	0.7	1.6	4.0	1.7	-2.0	0.4	-0.8	0.8	0.8	-1.6	0.8
Bone: maximum diameter	2.5	4.6	10.6	3.3	-3.2	1.1	-1.4	1.5	1.4	-2.5	1.5
Bone: maximum force	2.4	4.1	10.6	3.0	-3.0	-0.0	-0.2	0.2	0.1	-3.3	2.1
Bone: maximum moment	2.6	4.4	11.4	3.1	-3.1	-0.0	-0.1	0.2	0.0	-3.4	2.2
Mean time between licks in bursts	0.7	1.0	1.7	-1.3	1.2	-0.8	1.0	-0.7	-0.9	1.2	-0.9
Mean num. licks in bursts	0.9	1.1	2.3	1.5	-1.3	1.1	-0.8	0.9	1.1	-1.0	0.2
Cd content in liver	0.5	0.6	2.6	0.3	0.2	1.0	-0.4	0.7	0.4	0.5	-1.6
Co content in liver	0.1	0.1	0.5	0.3	-0.2	-0.2	0.7	-0.3	-0.5	-0.2	0.2
Cu content in liver	2.6	3.1	5.6	-2.4	2.1	-2.0	1.8	-1.4	-1.7	1.3	-1.1
Fe content in liver	0.1	0.1	0.3	0.5	-0.6	0.4	-0.4	0.5	0.2	0.2	0.2
K content in liver	0.5	0.5	0.9	-0.7	0.4	-1.0	0.7	-0.6	-0.8	0.4	0.8
Mg content in liver	0.6	0.6	1.3	-0.7	0.3	-1.1	0.7	-0.5	-1.0	0.3	1.0
Mn content in liver	0.4	0.4	1.0	-0.1	0.2	0.8	-1.0	0.6	1.0	0.1	-0.6
Na content in liver	1.3	1.3	2.2	-1.5	1.3	-1.1	1.1	-1.1	-1.3	1.0	-0.5
Rb content in liver	0.2	0.2	0.3	-0.0	-0.1	-0.6	0.5	-0.5	-0.4	-0.5	0.4
Se content in liver	1.5	1.8	6.1	-1.5	1.7	0.2	-0.3	0.2	0.2	1.6	-2.5
Sr content in liver	1.7	1.6	3.3	-1.6	1.8	-0.5	1.0	-0.6	-0.8	1.4	-1.5
Zn content in liver	0.8	0.9	2.1	-1.5	1.3	-0.9	0.6	-0.7	-0.8	1.1	-0.4
Bone: minimum diameter	0.7	1.3	3.0	1.5	-1.7	0.2	-0.6	0.7	0.4	-1.5	1.4
Time in familiar zone, hab. session 1	0.4	0.4	1.8	0.2	-0.3	-0.6	0.2	-0.7	-0.2	-1.3	-0.0
Time in novel zone, hab. session 1	0.5	0.5	1.0	0.5	-0.3	1.0	-0.4	1.0	0.3	1.0	0.0
Total zone transitions, hab. session 1	2.3	3.2	7.9	-2.7	2.8	-1.2	0.7	-1.6	-0.7	1.1	-2.2
Total locomotion distance, hab. session 1	1.3	1.9	4.8	-2.1	2.2	-0.4	-0.1	-0.7	0.1	1.1	-2.0
Locomotion velocity, hab. session 1	1.3	1.8	4.6	-2.1	2.1	-0.9	0.4	-1.1	-0.3	0.8	-1.6
Time in familiar zone, hab. session 2	0.6	0.7	1.3	-0.6	0.9	0.8	-0.7	0.6	0.8	1.0	-1.1
Time in novel zone, hab. session 2	0.6	0.6	1.2	0.6	-0.8	-0.7	0.7	-0.7	-0.8	-0.8	1.1
Total zone transitions, hab. session 2	1.6	2.1	4.4	-1.0	0.8	-2.1	1.7	-2.1	-1.7	-0.9	0.3
Total locomotion distance, hab. session 2	1.3	1.7	3.6	-1.0	0.7	-1.9	1.6	-1.7	-1.6	-0.2	0.4
Locomotion velocity, hab. session 2	1.8	2.5	5.0	-1.4	1.0	-2.2	1.9	-2.1	-1.9	-0.1	0.5
Novel to familiar place preference ratio	1.0	1.0	2.1	1.2	-0.7	1.4	-1.0	1.0	1.0	-0.3	-1.1
Novelty place preference	1.7	1.7	3.5	1.5	-0.8	1.9	-1.4	1.3	1.3	-0.4	-1.4
Time in novel zone, NPP test	2.1	2.1	4.1	1.7	-1.0	2.0	-1.5	1.4	1.5	-0.5	-1.5
Total zone transitions, NPP test	2.5	3.6	6.6	-2.6	2.6	-1.9	1.4	-2.3	-1.4	0.6	-1.7
Total locomotion distance, NPP test	1.1	1.5	2.9	-1.5	1.4	-1.5	1.0	-1.7	-1.0	0.2	-0.5
Locomotion velocity, NPP test	1.4	2.0	3.8	-2.0	1.8	-1.6	1.1	-1.8	-1.1	0.6	-0.6
Intraocular pressure	0.7	1.0	1.9	1.1	-1.0	0.9	-1.4	0.7	1.3	-1.0	0.2
Delta distance traveled before/after self-admin	0.6	0.7	1.7	1.0	-0.8	0.1	-0.3	-0.4	0.1	-1.3	1.3
Delta ambulatory time before/after self-admin	1.0	1.1	3.1	1.1	-1.0	-0.4	0.1	-0.8	-0.3	-1.6	1.8
Parametrial fat weight	0.1	0.3	0.8	0.6	-0.1	0.9	-0.6	0.4	0.3	-0.2	-0.6
Pavlov. Cond. lever latency	0.3	0.3	0.9	1.0	-0.7	0.7	-0.4	0.2	0.2	-0.6	0.5
Pavlov. Cond. magazine entry latency	0.7	0.9	1.9	-0.7	0.5	-1.4	1.3	-1.3	-1.0	-0.2	0.7
Pavlov. Cond. change in total contacts	1.6	1.7	3.6	-0.9	0.5	-1.9	1.6	-1.8	-1.5	-0.5	0.9
Pavlov. Cond. index score	0.3	0.4	0.9	-0.3	-0.0	-0.9	0.8	-0.7	-0.4	-0.3	0.8
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.3	0.1	-0.8	0.7	-0.5	-0.4	-0.0	0.5
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-0.9	0.6	-1.0	0.9	-0.6	-0.6	0.5	0.0
Pavlov. Cond. magazine entry number	0.3	0.4	1.0	0.6	-0.4	0.9	-0.8	1.0	0.5	0.2	-0.5
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.6	-1.1	1.0	-1.5	1.2	-1.6	-1.6	-0.2	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.9	-0.5	0.2	-0.9	0.7	-0.8	-0.4	-0.2	0.5
Pavlov. Cond. response bias	0.5	0.6	1.3	-0.6	0.3	-1.1	1.0	-0.9	-0.6	-0.2	0.8
Pavlov. Cond. lever latency	0.7	1.0	1.6	1.2	-0.7	1.1	-1.3	0.5	1.2	-1.0	0.6
Pavlov. Cond. magazine entry latency	2.5	2.9	5.7	-1.5	1.0	-2.4	2.3	-2.0	-2.3	0.3	0.1
Pavlov. Cond. change in total contacts	1.1	1.6	3.1	-0.1	-0.8	-1.8	1.6	-1.1	-1.6	-0.8	1.4
Pavlov. Cond. index score	1.5	1.9	3.5	-1.5	0.8	-1.9	1.8	-1.4	-1.8	0.6	-0.1
Pavlov. Cond. latency score	1.9	2.3	4.3	-1.6	0.9	-2.1	2.0	-1.7	-2.0	0.6	-0.0
Pavlov. Cond. lever contacts	0.6	0.8	1.5	-1.2	0.6	-1.0	1.1	-0.2	-1.0	1.0	-0.7
Pavlov. Cond. magazine entry number	0.9	1.2	2.4	1.0	-0.5	1.5	-1.4	1.3	1.4	-0.2	0.0
Pavlov. Cond. intertrial magazine entries	0.9	1.2	2.9	1.7	-1.4	0.9	-0.6	0.6	0.7	-1.5	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.7	3.2	-1.5	0.8	-1.8	1.7	-1.2	-1.7	0.7	-0.2
Pavlov. Cond. response bias	0.7	1.0	2.2	-1.0	0.3	-1.5	1.5	-0.7	-1.4	0.5	-0.1
Time in closed arm before self-admin	3.4	3.8	7.3	-1.7	1.2	-2.4	2.6	-2.1	-2.7	1.2	0.6
Time in closed arm after self-admin	0.5	0.5	1.4	1.0	-1.2	0.1	0.1	0.2	-0.0	-0.9	0.8
Time in open arm before self-admin	0.6	0.6	1.2	0.0	0.2	1.1	-0.8	1.0	1.1	0.3	-0.8
Time in open arm after self-admin	0.7	0.8	2.3	-1.1	1.3	0.3	-0.0	0.3	0.0	1.5	-0.9
Bone: periosteal estimation	1.2	2.5	5.9	2.3	-2.4	0.5	-0.8	1.0	0.9	-2.1	1.3
Bone: periosteal perimeter	2.5	4.2	8.6	2.9	-2.9	1.4	-1.7	1.9	1.5	-1.9	1.6
Bone: post-yield work	1.3	1.8	5.3	1.0	-1.0	-1.3	1.1	-1.1	-1.2	-2.3	1.1
Progressive ratio test 1 active lever presses	1.3	1.3	3.3	0.8	-0.9	-1.1	1.0	-1.0	-0.8	-1.8	1.4
Progressive ratio test 1 breakpoint	0.8	0.8	2.2	0.6	-0.6	-0.8	0.9	-0.8	-0.7	-1.5	1.1
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.4	0.2	-0.5	-1.1	1.2	-0.9	-1.2	-0.6	1.1
Progressive ratio test 2 active lever presses	0.5	0.6	1.7	0.3	-0.2	-0.7	0.4	-1.1	-0.4	-1.3	0.9
Progressive ratio test 2 breakpoint	0.7	0.8	2.1	0.5	-0.5	-0.7	0.4	-1.1	-0.5	-1.5	1.2
Progressive ratio test 2 inactive lever presses	1.0	1.2	2.6	-0.5	0.4	-1.6	1.3	-1.5	-1.2	-0.5	0.8
Incentive Sensitization - Responses	0.2	0.2	0.5	-0.5	0.7	0.1	-0.5	-0.3	0.2	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.1	0.3	-0.3	0.4	0.3	-0.6	-0.1	0.3	0.1	-0.3
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	-0.3	0.3	-0.6	0.6	-0.2	-0.6	0.4	0.2
Progressive ratio	0.5	0.6	1.2	-0.2	0.1	-1.1	1.1	-0.8	-1.1	-0.1	0.6
Food seeking constrained by brief footshock	0.4	0.5	1.5	1.0	-1.0	0.1	-0.3	0.3	0.5	-1.2	0.4
Seeking ratio, punishment vs. effort	0.3	0.4	0.6	0.7	-0.7	0.5	-0.6	0.4	0.7	-0.8	0.1
Retroperitoneal fat weight	4.4	14.3	22.0	4.4	-3.8	4.3	-4.7	4.1	4.3	-2.2	0.3
Reaction time number correct	1.1	1.6	5.5	-1.4	1.6	0.5	-0.6	0.2	0.8	1.3	-2.3
Reaction time mean minus median	0.0	0.0	0.2	0.0	-0.0	0.1	0.0	0.2	-0.1	0.5	0.1
Reaction time mean minus median AUC	0.4	0.5	1.2	0.7	-0.6	1.0	-0.8	1.1	0.7	0.5	0.1
Reaction time num false alarms	0.1	0.2	0.8	-0.3	0.2	0.1	0.1	0.4	-0.2	0.9	-0.6
Reaction time num false alarms AUC	0.2	0.3	0.9	-0.6	0.5	0.1	0.1	0.2	-0.2	0.9	-0.8
Reaction time trials correct on left	1.1	1.6	5.5	-1.4	1.6	0.5	-0.6	0.2	0.8	1.3	-2.3
Reaction time trials on left	1.2	1.7	5.7	-1.4	1.7	0.5	-0.6	0.1	0.7	1.3	-2.4
Reaction time mean	0.1	0.1	0.6	-0.1	0.0	0.1	0.0	0.4	-0.2	0.7	0.3
Reaction time mean AUC	0.1	0.1	0.4	-0.1	0.0	0.1	-0.1	0.4	-0.1	0.6	0.1
Median of all reaction times	0.1	0.1	0.5	-0.3	0.1	-0.2	0.2	0.3	-0.4	0.7	0.3
Reaction time omissions	0.2	0.3	0.8	-0.9	0.7	-0.4	0.3	-0.3	-0.5	0.7	-0.1
Reaction time false alarm rate	0.0	0.1	0.2	0.1	-0.2	-0.0	0.3	0.2	-0.4	0.4	0.1
Reaction time premature initiation rate	0.6	0.8	2.3	0.4	-0.9	-1.0	1.0	-0.6	-0.8	-0.7	1.5
Reaction time premature initiations	0.1	0.1	0.3	-0.0	-0.3	-0.5	0.5	-0.4	-0.3	-0.2	0.3
Std. dev. reaction times	0.2	0.2	0.5	0.5	-0.5	0.6	-0.3	0.7	0.3	0.3	0.3
Reaction time trials completed	1.2	1.7	5.7	-1.4	1.7	0.5	-0.6	0.1	0.7	1.3	-2.4
Reaction time trials AUC	0.9	1.3	4.6	-1.1	1.3	0.6	-0.7	0.3	0.8	1.0	-2.1
Run reversals in cocaine runway, females	0.9	0.9	3.8	-0.8	1.1	0.5	-0.7	0.1	0.3	0.9	-1.9
Run reversals in cocaine runway, males	0.4	0.4	1.5	0.6	-0.5	0.3	-0.6	0.2	0.8	-1.2	0.1
Latency to leave start box in cocaine runway	1.5	1.6	3.3	0.8	-0.8	1.6	-1.7	1.8	1.7	0.4	-0.2
Latency to leave start box in cocaine runway, F	0.2	0.2	0.4	-0.3	0.1	0.3	-0.5	0.6	0.6	0.6	-0.1
Latency to leave start box in cocaine runway, M	3.0	2.9	5.1	1.6	-1.3	2.3	-2.2	2.2	2.0	-0.0	-0.2
Std. dev. time between licks in bursts	1.0	1.3	2.4	-1.1	0.7	-1.6	1.4	-1.4	-1.4	0.3	0.2
Total sessions with >9 infusions	1.8	1.9	5.2	2.0	-1.9	0.0	-0.1	0.2	0.2	-2.3	1.6
Short access day 1 total inactive lever presses	2.7	3.0	4.5	0.8	-1.1	-2.0	2.0	-1.7	-1.7	-2.1	2.1
Short access day 10 total inactive lever presses	0.1	0.1	0.4	0.3	-0.3	0.1	0.1	0.0	0.0	-0.3	0.6
Short access day 1 total infusions	0.7	0.7	1.7	1.1	-1.1	-0.2	0.3	-0.1	-0.3	-1.3	1.2
Short access day 10 total infusions	2.0	2.2	4.9	2.0	-2.2	-0.1	0.1	0.2	0.1	-2.1	2.1
Short access total infusions	2.3	2.6	6.0	2.2	-2.4	-0.2	0.0	0.2	-0.1	-2.4	2.1
Short access day 1 locomotion	0.7	0.7	2.4	0.3	-0.5	-0.7	1.1	-0.4	-0.9	-0.6	1.5
Short access day 10 total locomotion	0.9	1.0	2.7	-0.2	-0.1	-0.6	1.5	-0.3	-1.4	0.3	1.6
Short access total locomotion	1.7	1.8	5.9	1.4	-1.7	-0.3	0.9	0.1	-0.7	-1.5	2.4
One hour access (0.3 mA shock)	0.7	0.9	1.9	-0.9	0.7	-1.4	1.1	-1.2	-1.0	-0.1	0.4
Compulsive drug intake	1.8	1.9	4.0	-2.0	2.0	-0.9	0.9	-1.8	-0.9	0.6	-1.0
One hour access (shock baseline)	0.1	0.2	0.4	0.5	-0.7	-0.1	0.1	0.4	-0.1	-0.3	0.5
Social response proportion	0.3	0.3	0.6	0.2	-0.5	-0.4	0.8	0.3	-0.7	0.6	0.3
Social responses	0.4	0.5	1.1	-0.5	0.3	-1.1	0.9	-1.0	-0.9	-0.3	0.2
Social time	2.4	3.1	5.3	-1.8	1.2	-2.3	2.2	-1.8	-2.2	0.7	1.0
Soleus weight	0.4	1.2	2.8	-0.7	0.6	-1.2	1.2	-1.7	-1.3	-0.5	0.9
Bone: stiffness	1.5	2.4	6.0	2.4	-2.4	-0.1	-0.0	0.2	-0.2	-2.4	1.4
Tibialis anterior weight	1.1	3.8	7.8	-1.7	1.5	-2.3	2.8	-2.2	-2.5	0.8	0.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.2	-0.1	-0.2	0.1	-0.6	-0.1	-0.5	0.0
Time to tail flick, vehicle, after self-admin	0.3	0.3	0.7	-0.8	0.8	-0.1	0.3	-0.2	-0.2	0.8	-0.7
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	0.1	0.1	-0.3	0.0	0.2	-0.2	-0.4
Time to tail flick, test, after self-admin	1.2	1.3	2.2	-1.5	1.5	-0.9	0.9	-1.0	-1.0	1.1	-1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	-0.4	0.3	-0.4	0.7	0.0	-0.5	0.6	0.2
Delta time to tail flick, test, before/after SA	2.5	2.3	3.9	-1.9	2.0	-0.9	1.1	-1.2	-1.2	1.7	-1.6
Tibia length	0.8	2.2	5.4	1.9	-1.9	0.4	-0.8	0.6	1.1	-2.3	1.6
Ambulatory time before self-admin	0.6	0.6	0.9	-0.9	0.7	-0.9	1.0	-0.7	-0.9	0.3	0.4
Ambulatory time after self-admin	1.9	2.1	3.8	-0.5	0.4	-1.8	1.6	-1.8	-1.8	-0.6	1.9
Bone: tissue strength	0.2	0.2	0.3	0.5	-0.4	0.3	-0.5	0.4	0.4	-0.5	0.2
Total heroin consumption	0.2	0.2	0.8	0.2	-0.3	-0.6	0.2	-0.7	-0.1	-0.9	0.1
Bone: trabecular number	0.2	0.3	0.6	0.1	0.2	0.8	-0.7	0.7	0.8	0.4	-0.3
Bone: trabecular spacing	1.3	1.7	4.9	1.6	-1.7	-0.4	0.2	-0.4	-0.3	-2.2	1.7
Bone: trabecular thickness	0.5	0.5	1.4	-0.5	0.6	0.5	-0.3	0.7	0.4	1.2	-1.1
Bone: trabecular tissue density	1.0	1.4	2.1	-1.3	1.2	-1.1	1.4	-1.1	-1.5	1.1	-0.6
Water consumed over 24 hours	0.3	0.4	1.7	0.9	-0.4	-0.1	0.4	-0.6	-0.4	-1.3	-0.3
Number of responses in last shaping day	1.8	1.9	4.1	0.1	-0.5	-2.0	1.5	-1.4	-1.7	-0.8	1.8