Cabp7

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	Cabp7	0.03	0.02	4.5e-03	0	0.01	0	0	1.5e-01	4.7e-02	1.2e-01	2.1e-01
2	PL	gene expression	Cabp7	0.08	0.05	2.2e-08	0.01	0.06	0.05	0.04	1.0e-02	2.2e-07	7.6e-06	2.0e-05
3	Brain	gene expression	Cabp7	0.2	0.1	0.0e+00	0.19	0.2	0.2	0.18	9.4e-18	1.4e-18	2.5e-18	3.4e-16
4	IL	gene expression	Cabp7	0.26	0.16	5.6e-04	0.15	0.14	0.12	0.13	2.1e-04	3.1e-04	7.1e-04	5.2e-04
5	NAcc	gene expression	Cabp7	0.02	0.01	2.2e-03	0.01	0.01	0.01	0.01	2.0e-02	2.8e-03	4.3e-03	1.0e-02
6	IC	gene expression	Cabp7	0.31	0.13	1.4e-09	0.22	0.2	0.22	0.22	1.1e-09	5.2e-09	1.3e-09	1.9e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.5	0.9	1.4	-1.0	-1.1	-0.9	1.2	-0.9	0.6
Area under the delay curve	0.7	1.0	3.3	1.8	1.6	-0.4	-0.3	-0.0	-0.3
BMI with tail	0.2	0.6	0.8	0.7	0.8	0.8	-0.9	0.8	-0.7
BMI without tail	0.1	0.6	1.2	0.4	0.2	-1.1	0.7	-0.9	0.8
Body weight	0.3	1.2	3.5	1.9	1.6	-0.9	0.2	-0.5	0.3
Weight adjusted by age	0.2	0.7	1.2	0.2	-0.0	-1.1	1.0	-1.0	0.9
Bone surface	0.1	0.1	0.2	0.0	-0.0	-0.4	0.5	-0.4	-0.2
Bone volume	0.1	0.2	0.4	-0.2	-0.3	-0.6	0.6	-0.6	0.1
Breakpoint value in progressive ratio session	0.1	0.2	0.6	0.8	0.7	-0.0	-0.3	0.0	-0.2
Number of licking bursts	0.2	0.6	1.2	1.1	0.8	-1.0	0.5	-0.7	0.3
Context. condit. distance diff. score	0.8	1.0	3.0	-1.7	-1.5	0.6	-0.0	0.3	0.2
Locomotion velocity, session 1	2.9	3.2	4.3	1.2	1.4	2.0	-2.0	2.1	-1.9
Locomotion distance, session 1	0.7	0.9	1.7	-1.3	-1.3	-0.6	0.6	-0.8	0.9
Locomotion velocity, session 2	2.9	3.5	4.9	1.1	1.3	2.1	-2.2	2.0	-2.1
Locomotion distance, session 2	0.7	0.9	1.7	-0.9	-0.6	1.3	-1.0	1.0	-0.9
Locomotion velocity, session 3	1.0	1.2	3.3	-1.8	-1.7	-0.0	0.5	-0.4	0.7
Locomotion distance, session 3	0.0	0.0	0.2	-0.0	0.0	0.2	-0.4	0.0	-0.2
Stereotopy head waving bouts, day 3	0.4	0.4	1.3	-1.1	-1.0	0.0	0.1	-0.3	0.4
Stereotopy head waving duration, day 3	0.4	0.5	1.3	-1.1	-1.0	0.6	-0.2	0.3	0.0
Locomotion velocity, session 7	0.1	0.2	0.2	0.4	0.4	0.3	-0.5	0.3	-0.5
Locomotion distance, session 7	0.2	0.3	0.6	-0.2	-0.1	0.8	-0.6	0.7	-0.6
Stereotopy head waving bouts, day 7	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.2	-0.2	0.3
Stereotopy head waving duration, day 7	0.3	0.3	0.5	-0.4	-0.5	-0.6	0.6	-0.6	0.7
Locomotion velocity, session 8	1.5	1.9	3.6	-0.3	0.1	1.9	-1.7	1.6	-1.4
Locomotion distance, session 8	1.6	2.3	6.8	-2.6	-2.2	1.2	-0.3	0.7	-0.0
Degree of sensitization distance	0.4	0.5	0.9	-0.6	-0.4	0.9	-0.4	0.9	-0.5
Degree of sensitization stereotypy	0.1	0.1	0.4	0.2	0.1	-0.5	0.6	-0.3	0.3
Conditioned locomotion	1.5	1.8	2.8	-1.7	-1.7	-0.9	1.2	-1.0	1.4
Cocaine response after cond. corrected	0.3	0.4	1.1	1.0	0.8	-0.7	0.4	-0.5	0.2
Cocaine response after cond. not corrected	0.5	0.8	1.5	0.8	0.6	-1.2	0.7	-1.0	0.8
Cocaine response before conditioning	0.3	0.3	0.5	-0.7	-0.7	-0.3	0.2	-0.5	0.6
Saline control response	0.3	0.4	0.8	-0.4	-0.3	0.9	-0.7	0.7	-0.6
Bone: connectivity density	0.4	0.6	1.0	-1.0	-1.0	-0.6	1.0	-0.7	0.3
Bone: cortical apparent density	0.1	0.2	0.4	0.6	0.5	-0.4	0.1	-0.3	0.2
Bone: cortical area	0.4	0.7	1.3	1.1	0.9	-1.1	0.5	-0.8	0.3
Bone: cortical porosity	0.2	0.2	0.4	-0.2	-0.3	-0.6	0.6	-0.5	0.4
Bone: cortical porosity	0.4	0.4	0.6	-0.6	-0.7	-0.5	0.8	-0.6	0.6
Bone: cortical thickness	0.8	1.3	2.9	0.4	0.1	-1.7	1.2	-1.6	1.0
Bone: cortical thickness	2.1	2.6	3.1	-1.7	-1.7	-1.4	1.8	-1.5	1.5
Bone: cortical tissue density	0.1	0.2	0.5	0.7	0.6	-0.3	-0.0	-0.2	0.1
Condit. Reinf. active minus inactive responses	2.1	2.4	3.1	1.4	1.5	1.4	-1.6	1.5	-1.8
Condit. Reinf. active-inactive response ratio	5.2	5.6	7.5	1.5	1.8	2.7	-2.5	2.7	-2.7
Condit. Reinf. active responses	0.8	1.0	1.3	0.8	0.9	0.9	-1.1	1.0	-1.1
Condit. Reinf. inactive responses	0.6	0.8	1.4	-0.5	-0.7	-1.1	0.8	-1.2	0.9
Incentive salience index mean	1.2	1.5	1.9	1.3	1.4	0.9	-1.3	1.0	-1.4
Condit. Reinf. lever presses	0.0	0.0	0.1	0.3	0.2	-0.1	-0.3	-0.1	-0.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.7	-0.6	0.2	0.2	0.1	0.0
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.0	0.1	0.3	-0.0	0.3	-0.2
Condit. Reinf. active responses	0.1	0.2	0.4	-0.6	-0.5	0.6	-0.2	0.5	-0.2
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.5	-0.4	0.7	-0.5	0.6	-0.3
Condit. Reinf. lever presses	0.2	0.2	0.7	-0.9	-0.8	0.1	0.2	-0.1	0.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.3	-0.6	-0.5	0.5	-0.2	0.4	-0.2
Conditioned reinforcement - actives	0.1	0.2	0.6	0.8	0.7	0.1	-0.3	0.1	-0.3
Conditioned reinforcement - inactives	0.2	0.5	1.4	1.2	1.1	0.1	-0.3	0.3	-0.3
Conditioned locomotion	0.2	0.3	0.7	0.8	0.7	-0.6	0.2	-0.4	0.2
Patch foraging indifference point 0 sec	0.2	0.5	1.2	1.1	0.8	-0.8	0.3	-0.6	0.3
Patch foraging indifference point AUC	0.1	0.2	0.3	0.3	0.3	0.4	-0.5	0.3	-0.4
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	0.8	0.6	-0.8	0.4	-0.6	0.5
Delay disc. indifference point, 16s delay	1.6	2.3	4.5	2.1	2.1	0.8	-1.3	1.0	-1.3
Delay disc. indifference point, 2s delay	1.3	1.4	2.9	0.3	0.1	-1.7	1.3	-1.5	1.3
Delay disc. indifference point, 24s delay	0.6	1.0	2.0	1.4	1.4	0.5	-0.8	0.7	-0.8
Delay disc. indifference point, 4s delay	0.8	0.8	1.6	1.0	0.7	-1.2	0.6	-1.0	0.7
Delay disc. indifference point, 8s delay	0.3	0.5	1.4	1.2	1.1	0.1	-0.4	0.3	-0.4
Indifference point function ln k	0.2	0.7	0.8	-0.7	-0.8	-0.8	0.9	-0.9	0.8
Indifference point function log k	0.2	0.7	0.8	-0.7	-0.8	-0.8	0.9	-0.9	0.8
Patch foraging total patch changes 0 sec	0.2	0.5	1.5	1.2	1.0	-0.6	0.1	-0.4	0.0
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	0.8	0.6	-0.6	0.1	-0.4	0.4
Patch foraging total patch changes 18 sec	0.9	2.2	3.7	1.9	1.9	0.9	-1.3	1.2	-1.4
Patch foraging total patch changes 24 sec	0.1	0.4	0.9	-0.4	-0.2	1.0	-0.5	0.9	-0.7
Patch foraging total patch changes 6 sec	0.3	0.4	1.4	1.2	1.0	-0.3	-0.3	-0.1	-0.3
Patch foraging time to switch 0 sec	0.0	0.1	0.3	-0.5	-0.5	-0.2	0.4	-0.2	0.4
Patch foraging water rate 0 sec	0.3	1.0	2.1	1.5	1.4	0.3	-0.9	0.5	-0.9
Patch foraging water rate 12 sec	0.0	0.0	0.1	-0.1	-0.1	0.0	0.1	-0.0	-0.3
Patch foraging water rate 18 sec	1.6	3.6	5.1	-1.4	-1.6	-2.0	2.3	-2.0	2.0
Patch foraging water rate 24 sec	0.4	0.6	0.8	0.5	0.6	0.8	-0.8	0.9	-0.9
Patch foraging water rate 6 sec	0.2	0.2	0.5	0.1	-0.1	-0.7	0.6	-0.7	0.3
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.2	-0.2
Distance traveled before self-admin	0.7	1.4	2.3	-0.4	-0.6	-1.5	1.4	-1.5	1.3
Distance traveled after self-admin	1.4	2.4	3.3	-0.9	-1.1	-1.8	1.7	-1.8	1.8
Extensor digitorum longus weight	0.6	2.3	4.8	2.2	1.7	-1.8	0.8	-1.3	0.6
Bone: elastic displacement	1.0	1.3	1.6	-1.1	-1.2	-1.0	1.3	-1.0	1.2
Bone: elastic work	1.7	2.3	3.2	-0.8	-1.0	-1.8	1.8	-1.7	1.7
Bone: endosteal estimation	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	-0.1	0.1
Bone: endosteal perimeter	0.1	0.3	1.1	1.0	0.9	-0.1	-0.1	0.1	-0.2
Epididymis fat weight	0.1	0.3	0.6	0.4	0.2	-0.8	0.4	-0.8	0.5
Delta time in closed arm before/after self-admin	2.0	1.9	5.9	-2.4	-2.1	0.3	0.6	-0.0	0.5
Delta time in open arm before/after self-admin	2.2	2.7	7.4	2.7	2.5	0.1	-1.1	0.4	-1.0
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.3	-0.3	-0.2	0.3	-0.2	0.5
Delay discount exponential model param	0.7	0.9	3.0	-1.7	-1.5	0.4	0.2	0.1	0.2
Extinction: sum of active levers before priming	0.6	1.0	1.3	0.8	0.9	1.0	-1.2	1.0	-1.1
Active lever presses in extinction session 6	0.3	0.3	0.4	-0.3	-0.4	-0.5	0.5	-0.6	0.7
Bone: final force	0.0	0.1	0.1	0.3	0.3	-0.3	0.2	-0.3	-0.1
Bone: final moment	0.1	0.2	0.3	0.3	0.2	-0.6	0.4	-0.5	0.1
Food consumed during 24 hour testing period	1.3	2.7	3.7	1.9	1.9	1.2	-1.7	1.3	-1.7
Glucose	25.2	39.9	57.2	7.5	7.6	4.6	-6.1	5.5	-6.1
Heart weight	1.3	2.1	3.0	1.0	1.2	1.5	-1.4	1.6	-1.7
Delay discount hyperbolic model param	0.6	0.8	2.6	-1.6	-1.4	0.6	0.0	0.3	0.0
Intermittent access intake day 1-15 change	0.3	1.9	2.4	1.5	1.5	1.1	-1.4	1.1	-1.4
Intermittent access intake escalation	0.3	1.4	1.8	1.3	1.4	1.0	-1.2	1.0	-1.2
Intermittent access intake escalation 2	0.1	0.2	0.4	0.6	0.6	0.4	-0.4	0.4	-0.4
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.1	-0.0	0.4	-0.1	0.4	-0.1
Intermitt. access day 15 inactive lever presses	0.6	3.0	4.1	2.0	2.0	1.3	-1.7	1.5	-1.7
Intermitt. access escalation Index	0.6	1.9	2.6	0.8	1.0	1.6	-1.6	1.5	-1.6
Intermittent access day 1 total infusions	0.2	0.6	1.1	0.2	0.0	-1.0	0.8	-0.9	0.8
Intermittent access day 15 total infusions	0.3	0.8	2.4	1.6	1.4	-0.1	-0.4	0.1	-0.4
Intermittent access terminal intake (last 3 days)	0.3	0.4	1.4	1.2	1.0	-0.3	-0.1	-0.2	-0.2
Intermittent access total infusions	0.3	0.4	1.0	1.0	0.8	-0.6	0.1	-0.4	0.1
Intermittent access day 1 locomotion	0.4	0.7	1.0	-0.5	-0.6	-0.9	1.0	-0.9	1.0
Intermittent access day 15 total locomotion	0.1	0.5	1.7	1.3	1.2	-0.1	-0.3	0.1	-0.2
Intermittent access total locomotion	0.3	0.3	1.1	1.0	0.9	-0.3	-0.0	-0.2	-0.0
Intermittent access standard deviation	0.1	0.6	0.8	-0.9	-0.9	-0.5	0.8	-0.6	0.9
Left kidney weight	0.3	2.5	3.9	-0.7	-0.9	-1.9	2.0	-1.7	1.9
Right kidney weight	1.1	7.7	11.0	-1.8	-2.1	-3.0	3.3	-2.9	3.1
Cocaine induced anxiety	0.3	0.9	2.5	1.6	1.4	0.1	-0.7	0.2	-0.7
Post-drug Anxiety	0.9	1.0	2.2	1.5	1.4	0.4	-0.8	0.5	-0.8
Baseline Anxiety	0.2	0.3	0.5	0.1	0.2	0.7	-0.6	0.7	-0.6
Tail length	0.7	3.7	7.8	1.2	0.6	-2.8	1.9	-2.3	1.9
Length with tail	0.7	3.1	6.4	1.4	0.9	-2.5	1.7	-2.0	1.6
Length without tail	0.0	0.1	0.3	0.5	0.4	-0.4	0.3	-0.3	0.1
Times rat made contact with spout	3.4	4.0	5.3	1.3	1.6	2.2	-2.3	2.2	-2.2
Lifetime Intake	0.3	0.4	0.7	0.8	0.6	-0.8	0.4	-0.7	0.4
Liver weight, left	1.4	2.3	3.0	-1.5	-1.6	-1.4	1.4	-1.5	1.7
Liver weight, right	0.9	1.6	2.6	-1.6	-1.6	-0.8	1.1	-1.0	1.3
Locomotor activity	0.9	1.4	2.5	1.6	1.6	0.7	-1.2	1.0	-0.9
Locomotor testing distance	0.4	0.9	1.7	0.1	-0.2	-1.3	0.9	-1.2	1.2
Locomotor testing rearing	0.2	0.6	1.9	1.4	1.2	-0.4	-0.4	-0.1	-0.1
Locomotion in novel chamber	1.5	2.0	4.4	-2.1	-2.0	-0.6	1.3	-0.9	1.1
Locomotion in novel chamber post-restriction	0.6	1.7	3.6	-0.6	-0.3	1.9	-1.2	1.6	-1.4
Fecal boli incidents, locomotor time 1	0.1	0.1	0.2	-0.0	0.0	0.5	-0.4	0.4	-0.5
Change in fecal boli incidents, locomotor task	1.3	1.3	1.7	0.9	1.0	1.2	-1.3	1.3	-1.2
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.1	0.2	0.3	0.3	-0.3	0.4	-0.3
Bouts of movement, locomotor time 1	1.3	1.7	1.9	1.3	1.4	1.2	-1.4	1.3	-1.4
Total resting periods, locomotor time 1	1.9	2.2	2.7	1.2	1.3	1.6	-1.6	1.6	-1.7
Rest time, locomotor task time 1	0.4	0.6	0.9	0.5	0.6	0.8	-0.7	0.8	-0.9
Distance moved, locomotor task time 1	0.3	0.8	1.5	-0.1	-0.3	-1.2	0.9	-1.1	1.1
Vertical activity count, locomotor time 1	0.0	0.3	0.6	0.0	-0.1	-0.8	0.5	-0.6	0.7
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.3	0.4	0.5	-0.6	0.5	-0.5
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.1	-0.1	-0.0	0.0	-0.0	-0.0
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	0.1	0.2	-0.3	0.2	-0.3
Rest time, locomotor task time 2	0.1	0.2	0.3	-0.1	-0.0	0.6	-0.4	0.5	-0.5
Distance moved, locomotor task time 2	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	-0.1	0.2
Vertical activity count, locomotor time 2	0.0	0.1	0.1	0.0	-0.0	-0.4	0.3	-0.3	0.3
Light reinforcement 1	0.1	0.6	1.1	-0.3	-0.4	-1.0	0.6	-1.1	0.9
Light reinforcement 2	0.5	1.1	1.9	-0.3	-0.5	-1.4	1.2	-1.3	1.2
Bone: marrow area	0.0	0.0	0.0	0.2	0.1	-0.2	0.2	-0.1	0.1
Bone: maximum diameter	1.6	3.1	7.9	2.8	2.6	0.4	-1.2	0.8	-1.3
Bone: maximum force	0.1	0.3	0.6	-0.0	-0.1	-0.8	0.6	-0.7	0.4
Bone: maximum moment	0.3	0.6	1.2	-0.0	-0.2	-1.1	0.9	-1.0	0.7
Mean time between licks in bursts	0.4	2.6	3.1	1.5	1.6	1.5	-1.6	1.7	-1.7
Mean num. licks in bursts	1.0	2.8	5.5	-0.1	0.3	2.3	-2.1	2.1	-1.7
Cd content in liver	0.8	0.8	1.2	1.1	1.1	0.7	-1.0	0.8	-0.8
Co content in liver	0.2	0.3	0.5	-0.1	-0.2	-0.7	0.5	-0.7	0.6
Cu content in liver	0.2	0.2	0.4	0.5	0.6	0.3	-0.4	0.4	-0.6
Fe content in liver	0.6	0.7	1.4	-0.9	-0.6	1.2	-0.7	1.0	-0.7
K content in liver	1.5	1.5	3.1	0.1	-0.2	-1.8	1.1	-1.7	1.2
Mg content in liver	0.1	0.1	0.3	0.2	0.1	-0.5	0.2	-0.6	0.2
Mn content in liver	0.6	0.7	1.4	-0.5	-0.6	-1.1	0.6	-1.2	0.9
Na content in liver	1.2	1.4	3.1	1.8	1.7	0.4	-0.9	0.6	-1.0
Rb content in liver	0.4	0.5	0.9	0.8	0.6	-1.0	0.3	-0.8	0.4
Se content in liver	0.6	0.7	1.6	0.1	-0.1	-1.2	0.6	-1.3	0.8
Sr content in liver	2.0	1.7	4.0	2.0	1.9	0.4	-1.0	0.7	-1.0
Zn content in liver	0.3	0.3	0.7	-0.1	-0.2	-0.8	0.5	-0.8	0.6
Bone: minimum diameter	0.1	0.2	0.3	-0.4	-0.5	-0.5	0.5	-0.5	0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.5	-0.5	-0.2	0.3	-0.2	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.5	0.3	0.2	-0.7	0.5	-0.6	0.5
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.1	0.2	0.4	-0.4	0.3	-0.4
Total locomotion distance, hab. session 1	0.0	0.0	0.1	0.1	0.0	-0.2	-0.3	-0.3	0.2
Locomotion velocity, hab. session 1	0.2	0.2	0.7	0.2	0.3	0.5	-0.9	0.4	-0.4
Time in familiar zone, hab. session 2	0.3	0.3	0.9	-1.0	-0.8	0.3	0.2	0.3	0.2
Time in novel zone, hab. session 2	0.4	0.4	1.1	1.1	0.9	-0.4	-0.1	-0.4	-0.2
Total zone transitions, hab. session 2	0.2	0.3	0.6	0.7	0.7	0.2	-0.7	0.2	-0.4
Total locomotion distance, hab. session 2	0.7	0.9	1.6	1.1	1.1	0.6	-1.2	0.6	-0.8
Locomotion velocity, hab. session 2	0.6	0.8	1.3	1.1	1.1	0.4	-1.1	0.5	-0.6
Novel to familiar place preference ratio	1.3	1.7	2.6	1.6	1.6	1.0	-1.2	1.1	-1.2
Novelty place preference	1.3	1.7	2.6	1.6	1.6	0.9	-1.2	1.1	-1.2
Time in novel zone, NPP test	1.3	1.6	2.4	1.5	1.5	0.9	-1.2	1.0	-1.2
Total zone transitions, NPP test	0.5	0.7	1.4	-1.2	-1.2	-0.6	0.6	-0.8	0.7
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.6	-0.6	-0.2	0.1	-0.4	0.4
Locomotion velocity, NPP test	0.1	0.1	0.1	-0.3	-0.3	-0.2	0.0	-0.3	0.4
Intraocular pressure	1.0	1.6	1.9	1.2	1.3	1.2	-1.4	1.3	-1.3
Delta distance traveled before/after self-admin	0.1	0.1	0.4	-0.7	-0.6	0.1	0.2	0.0	0.2
Delta ambulatory time before/after self-admin	0.1	0.2	0.7	-0.8	-0.7	0.1	0.2	0.0	0.3
Parametrial fat weight	5.7	13.4	16.4	3.9	4.1	3.1	-3.6	3.5	-3.8
Pavlov. Cond. lever latency	0.3	0.4	0.8	0.9	0.9	0.3	-0.4	0.5	-0.5
Pavlov. Cond. magazine entry latency	0.6	0.7	2.3	-1.5	-1.3	0.4	0.2	0.1	-0.1
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.8	0.7	0.2	-0.4	0.2	-0.6
Pavlov. Cond. index score	0.7	0.9	2.9	-1.7	-1.5	0.1	0.4	-0.3	0.3
Pavlov. Cond. latency score	0.7	0.9	2.5	-1.6	-1.4	-0.1	0.5	-0.4	0.4
Pavlov. Cond. lever contacts	0.5	0.7	1.7	-1.3	-1.2	-0.2	0.5	-0.5	0.5
Pavlov. Cond. magazine entry number	0.6	0.8	2.4	1.5	1.3	-0.7	0.1	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	1.0	1.2	2.2	-0.1	-0.4	-1.5	1.3	-1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	3.7	-1.9	-1.7	-0.0	0.5	-0.4	0.4
Pavlov. Cond. response bias	0.5	0.7	2.0	-1.4	-1.3	0.0	0.3	-0.4	0.2
Pavlov. Cond. lever latency	1.5	2.1	4.6	0.8	0.4	-2.1	1.5	-1.8	1.4
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.4	-0.3	-0.0	0.3	-0.1	-0.1
Pavlov. Cond. change in total contacts	0.1	0.3	0.6	-0.0	0.1	0.7	-0.5	0.7	-0.6
Pavlov. Cond. index score	0.3	0.5	1.1	-0.6	-0.4	1.0	-0.6	0.9	-0.7
Pavlov. Cond. latency score	0.3	0.4	0.7	-0.9	-0.6	0.9	-0.3	0.6	-0.5
Pavlov. Cond. lever contacts	1.2	1.7	3.7	-1.0	-0.6	1.9	-1.2	1.6	-1.1
Pavlov. Cond. magazine entry number	0.2	0.2	0.6	-0.1	-0.2	-0.6	0.3	-0.6	0.7
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	0.1	-0.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.8	-0.8	-0.5	0.9	-0.4	0.7	-0.5
Pavlov. Cond. response bias	0.9	1.2	2.6	-0.5	-0.2	1.6	-1.0	1.4	-1.1
Time in closed arm before self-admin	0.5	0.9	1.5	-0.3	-0.5	-1.2	1.0	-1.2	1.2
Time in closed arm after self-admin	1.6	1.8	3.7	-1.9	-1.8	-0.6	1.1	-0.8	1.3
Time in open arm before self-admin	0.1	0.1	0.4	-0.7	-0.6	0.2	0.1	0.1	-0.1
Time in open arm after self-admin	2.2	2.5	3.2	1.7	1.8	1.2	-1.6	1.3	-1.7
Bone: periosteal estimation	0.1	0.3	0.6	0.8	0.6	-0.8	0.4	-0.6	0.3
Bone: periosteal perimeter	0.3	0.5	1.6	1.3	1.1	-0.5	0.1	-0.3	-0.0
Bone: post-yield work	0.0	0.0	0.0	0.2	0.1	-0.1	0.0	-0.1	-0.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	0.7	0.6	-0.4	0.1	-0.3	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.6	0.7	0.6	-0.3	0.0	-0.2	0.0
Progressive ratio test 1 inactive lever presses	0.6	1.5	4.4	2.1	1.9	-0.2	-0.6	0.0	-0.6
Progressive ratio test 2 active lever presses	0.3	0.4	1.3	1.1	1.0	-0.0	-0.3	0.1	-0.3
Progressive ratio test 2 breakpoint	0.4	0.5	1.2	1.1	1.0	0.1	-0.4	0.2	-0.5
Progressive ratio test 2 inactive lever presses	0.6	1.9	3.5	1.9	1.8	0.7	-1.2	0.9	-1.2
Incentive Sensitization - Responses	0.2	0.5	0.9	0.9	1.0	0.5	-0.6	0.6	-0.6
Incentive Sensitization - Breakpoint	0.2	0.5	0.8	0.9	0.9	0.5	-0.6	0.6	-0.6
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	0.0	0.0	-0.3	0.1	-0.3	0.2
Progressive ratio	0.1	0.2	0.3	-0.4	-0.4	-0.5	0.4	-0.5	0.5
Food seeking constrained by brief footshock	2.1	2.6	5.2	0.4	0.0	-2.3	1.8	-2.0	1.6
Seeking ratio, punishment vs. effort	0.2	0.4	0.7	0.2	0.0	-0.8	0.8	-0.7	0.6
Retroperitoneal fat weight	1.3	5.8	6.7	2.5	2.6	2.1	-2.6	2.4	-2.4
Reaction time number correct	0.1	0.5	0.9	0.4	0.5	0.8	-0.9	0.7	-0.9
Reaction time mean minus median	0.2	1.5	3.1	-0.0	0.3	1.8	-1.2	1.7	-1.2
Reaction time mean minus median AUC	0.1	0.4	0.9	-0.4	-0.2	0.9	-0.5	0.8	-0.4
Reaction time num false alarms	0.5	0.9	1.4	-0.5	-0.6	-1.1	0.9	-1.2	1.0
Reaction time num false alarms AUC	0.8	1.8	2.6	-0.9	-1.0	-1.5	1.4	-1.6	1.5
Reaction time trials correct on left	0.1	0.5	0.9	0.4	0.5	0.8	-0.9	0.7	-0.9
Reaction time trials on left	0.1	0.5	0.8	0.3	0.4	0.8	-0.8	0.7	-0.9
Reaction time mean	0.1	0.3	0.7	-0.3	-0.1	0.8	-0.4	0.8	-0.3
Reaction time mean AUC	0.1	0.2	0.4	-0.6	-0.4	0.6	-0.1	0.6	-0.1
Median of all reaction times	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.1	0.4	-0.0
Reaction time omissions	0.2	0.4	1.2	-1.1	-0.9	0.4	-0.0	0.2	0.2
Reaction time false alarm rate	2.0	2.7	3.7	-1.0	-1.2	-1.9	1.8	-1.9	1.9
Reaction time premature initiation rate	1.7	2.7	5.7	-2.4	-2.3	-0.7	1.3	-1.1	1.4
Reaction time premature initiations	0.4	1.1	3.0	-1.7	-1.6	-0.2	0.5	-0.5	0.6
Std. dev. reaction times	0.4	1.2	2.6	-0.1	0.2	1.6	-1.1	1.5	-0.9
Reaction time trials completed	0.1	0.5	0.8	0.3	0.4	0.8	-0.8	0.7	-0.9
Reaction time trials AUC	0.1	0.4	0.7	0.4	0.4	0.7	-0.7	0.6	-0.8
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.6	-0.4	0.6	-0.1	0.5	-0.1
Run reversals in cocaine runway, males	0.1	0.1	0.3	0.3	0.2	-0.5	0.4	-0.4	0.3
Latency to leave start box in cocaine runway	0.4	0.6	1.0	-0.3	-0.4	-0.9	0.9	-0.9	1.0
Latency to leave start box in cocaine runway, F	1.0	1.3	2.4	-0.1	-0.3	-1.5	1.3	-1.4	1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	-0.3	-0.2	0.5	-0.2	0.4	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.4	0.0	0.1	0.4	-0.2	0.4	-0.6
Total sessions with >9 infusions	1.3	1.6	1.8	-1.2	-1.3	-1.2	1.3	-1.4	1.3
Short access day 1 total inactive lever presses	0.5	1.0	2.0	1.4	1.1	-1.2	0.5	-1.0	0.5
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.0	-0.1	-0.4	0.4	-0.3	0.4
Short access day 1 total infusions	0.8	1.6	1.9	-1.2	-1.3	-1.2	1.3	-1.4	1.3
Short access day 10 total infusions	0.4	0.7	1.0	-0.6	-0.7	-0.9	0.9	-1.0	0.8
Short access total infusions	0.7	1.0	1.9	-0.3	-0.5	-1.3	1.1	-1.4	1.0
Short access day 1 locomotion	2.2	3.6	4.1	-1.9	-2.0	-1.8	1.9	-2.0	1.9
Short access day 10 total locomotion	0.6	2.3	2.7	-1.5	-1.6	-1.3	1.5	-1.5	1.5
Short access total locomotion	2.0	3.1	3.7	-1.8	-1.9	-1.5	1.7	-1.7	1.7
One hour access (0.3 mA shock)	0.4	0.5	1.6	1.3	1.1	-0.2	-0.3	-0.1	-0.3
Compulsive drug intake	0.4	0.6	1.6	-1.3	-1.2	0.0	0.4	-0.1	0.4
One hour access (shock baseline)	0.4	0.9	2.6	1.6	1.5	0.1	-0.6	0.2	-0.6
Social response proportion	2.4	3.0	3.7	1.8	1.9	1.5	-1.8	1.6	-1.7
Social responses	2.7	3.5	4.4	2.1	2.1	1.5	-2.0	1.6	-1.8
Social time	0.5	0.9	1.2	0.7	0.8	1.0	-1.1	1.1	-0.9
Soleus weight	0.9	2.6	5.1	0.2	-0.1	-2.2	1.9	-1.9	1.7
Bone: stiffness	0.0	0.0	0.0	-0.2	-0.1	0.1	0.0	0.0	-0.1
Tibialis anterior weight	0.2	0.8	2.5	1.6	1.4	-0.6	0.1	-0.2	-0.1
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.3	-0.2	-0.2	-0.5	0.5	-0.4	0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.3	-0.5	-0.5	-0.1	0.3	-0.1	0.4
Time to tail flick, test, before self-admin	0.4	0.5	0.6	-0.5	-0.6	-0.8	0.7	-0.8	0.8
Time to tail flick, test, after self-admin	0.6	0.6	1.2	0.9	0.6	-1.1	0.5	-0.9	0.6
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	-0.1	-0.0	0.4	-0.2	0.4	-0.2
Delta time to tail flick, test, before/after SA	0.7	0.9	1.5	1.2	1.2	0.5	-0.9	0.7	-0.8
Tibia length	1.4	3.9	5.3	-1.4	-1.6	-2.1	2.2	-2.0	2.3
Ambulatory time before self-admin	0.6	1.7	3.3	-0.2	-0.4	-1.8	1.5	-1.7	1.4
Ambulatory time after self-admin	1.1	1.7	2.3	-0.7	-0.9	-1.5	1.4	-1.5	1.5
Bone: tissue strength	0.0	0.0	0.1	0.3	0.2	0.1	-0.0	0.2	-0.2
Total heroin consumption	0.0	0.0	0.0	-0.2	-0.2	-0.2	0.1	-0.2	0.2
Bone: trabecular number	0.7	1.3	2.0	-0.9	-1.0	-1.2	1.4	-1.2	0.9
Bone: trabecular spacing	0.7	1.0	2.1	1.4	1.4	0.4	-1.1	0.6	-0.6
Bone: trabecular thickness	1.5	2.1	3.4	-1.8	-1.8	-0.9	1.6	-1.1	1.1
Bone: trabecular tissue density	0.8	1.3	2.3	0.4	0.7	1.5	-1.2	1.5	-1.2
Water consumed over 24 hours	1.1	2.1	2.5	1.6	1.6	1.1	-1.6	1.2	-1.5
Number of responses in last shaping day	0.1	0.1	0.2	-0.3	-0.2	0.4	-0.5	0.1	-0.4