Hub : Genes

C9h2orf88

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression C9h2orf88 0.04 0.03 8.8e-05 0.01 0.01 0.01 0 3.4e-02 1.6e-02 2.3e-02 8.9e-02
2 pVTA intron excision ratio chr9_56051719_56076002 0.28 0.14 5.6e-17 0.21 0.2 0.21 0.22 4.7e-17 3.2e-16 1.4e-16 3.4e-17
3 Liver gene expression C9h2orf88 0.03 0.02 1.1e-03 0.01 0.01 -0 0.01 3.2e-02 7.6e-03 8.0e-01 4.1e-02
4 NAcc gene expression C9h2orf88 0.05 0.03 1.8e-06 0.04 0.02 0.04 0.04 3.4e-07 1.2e-04 1.2e-06 1.4e-06
5 Brain intron excision ratio chr9_56051719_56076002 0.17 0.1 1.1e-13 0.15 0.14 0.14 0.14 1.0e-13 4.8e-13 4.4e-13 3.1e-13
6 NAcc intron excision ratio chr9_56051719_56076002 0.09 0.06 6.8e-08 0.03 0.04 0.04 0.04 7.9e-05 4.0e-07 4.1e-07 2.0e-07
7 pVTA gene expression C9h2orf88 0.07 0.05 7.7e-05 0.04 0.04 0.04 0.03 3.8e-04 4.8e-04 6.8e-04 8.6e-04
8 IC gene expression C9h2orf88 0.3 0.11 1.7e-09 0.19 0.17 0.17 0.17 2.7e-08 1.6e-07 1.6e-07 1.2e-07
9 IC intron excision ratio chr9_56051719_56076002 0.27 0.2 2.3e-03 0.02 0.03 0.02 0.02 6.3e-02 1.6e-02 3.5e-02 3.3e-02
10 pVTA intron excision ratio chr9_56052293_56076002 0.09 0.05 1.2e-05 0.04 0.07 0.06 0.06 2.2e-04 4.7e-06 8.1e-06 9.2e-06
11 Brain mRNA stability C9h2orf88 0.07 0.04 4.0e-06 0.06 0.06 0.05 0.06 2.6e-06 1.6e-06 2.2e-05 3.4e-06
12 Brain intron excision ratio chr9_56052293_56076002 0.07 0.04 2.7e-05 0.04 0.06 0.06 0.06 9.0e-05 7.7e-06 4.3e-06 6.1e-06
13 NAcc intron excision ratio chr9_56052293_56076002 0.06 0.04 8.0e-08 0.03 0.04 0.04 0.04 7.8e-06 2.1e-07 3.0e-06 7.1e-07
14 PL intron excision ratio chr9_56052293_56076002 0.04 0.03 5.4e-03 0 0.02 0.01 0.01 1.1e-01 6.3e-03 1.4e-02 2.2e-02
15 OFC gene expression C9h2orf88 0.5 0.19 1.7e-03 0.1 0.12 0.09 0.09 2.5e-03 8.2e-04 4.3e-03 3.6e-03
16 PL gene expression C9h2orf88 0.34 0.13 0.0e+00 0.18 0.24 0.25 0.25 8.8e-20 5.5e-26 1.2e-26 1.2e-26
17 Brain gene expression C9h2orf88 0.15 0.08 1.1e-10 0.1 0.11 0.11 0.1 3.0e-09 8.4e-11 3.3e-10 5.6e-10
18 PL mRNA stability C9h2orf88 0.06 0.04 2.4e-05 0.04 0.04 0.04 0.04 6.2e-05 1.7e-05 2.4e-05 1.6e-05
19 IC intron excision ratio chr9_56052293_56076002 0.14 0.08 5.7e-04 0.03 0.05 0.05 0.05 1.5e-02 2.8e-03 4.5e-03 3.3e-03
20 BLA gene expression C9h2orf88 0.15 0.1 1.7e-04 0.02 0.04 0.04 0.04 1.9e-02 3.1e-03 4.6e-03 2.7e-03
21 IL gene expression C9h2orf88 0.31 0.15 2.8e-04 0.18 0.16 0.2 0.2 4.8e-05 1.1e-04 1.6e-05 1.7e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density1.52.55.02.21.71.6-1.62.01.9-1.9-1.91.7-1.9-1.9-1.6-1.7-1.9-0.2-1.3-1.3-0.8-0.7-0.9-0.9
Area under the delay curve0.00.00.20.0-0.0-0.0-0.2-0.00.1-0.1-0.10.2-0.1-0.10.0-0.1-0.0-0.4-0.0-0.1-0.1-0.1-0.0-0.3
BMI with tail1.55.119.7-4.0-3.5-4.43.2-3.1-2.62.52.5-1.81.91.81.71.31.4-1.10.40.0-0.8-1.1-0.8-1.1
BMI without tail0.51.55.1-1.0-0.5-2.20.5-0.20.1-0.1-0.20.7-0.5-0.6-0.7-0.9-0.7-2.1-1.4-1.4-1.8-2.0-1.6-1.9
Body weight0.00.00.10.10.00.3-0.1-0.20.1-0.2-0.2-0.00.10.20.20.20.3-0.2-0.10.30.10.2-0.00.3
Weight adjusted by age1.01.54.20.3-0.31.50.1-0.5-0.50.70.7-0.90.90.91.11.11.01.91.61.51.81.82.11.8
Bone surface0.20.42.10.60.11.2-0.1-0.1-0.0-0.00.0-0.40.20.20.50.40.21.40.60.60.91.00.80.8
Bone volume0.50.93.61.81.21.9-1.11.11.1-1.2-1.10.6-0.9-0.9-0.5-0.6-0.90.9-0.3-0.20.30.40.20.3
Breakpoint value in progressive ratio session1.41.62.71.51.30.9-1.41.61.5-1.6-1.61.6-1.4-1.3-1.4-1.3-1.1-1.4-1.2-1.0-0.9-0.8-0.6-0.6
Number of licking bursts1.22.03.50.30.9-0.9-0.91.11.0-1.0-1.01.5-1.3-1.4-1.6-1.5-1.4-1.8-1.7-1.7-1.9-1.8-1.8-1.7
Context. condit. distance diff. score2.22.68.6-0.30.0-1.80.00.80.7-0.7-0.71.6-1.2-1.2-1.5-1.5-1.2-2.9-1.9-1.9-2.3-2.4-2.3-2.5
Locomotion velocity, session 10.10.10.5-0.0-0.0-0.30.10.30.3-0.3-0.30.3-0.2-0.2-0.5-0.3-0.1-0.7-0.5-0.3-0.5-0.4-0.4-0.4
Locomotion distance, session 10.40.51.4-0.7-1.1-0.41.2-0.6-0.80.80.9-0.60.70.70.40.70.80.10.70.60.40.40.70.3
Locomotion velocity, session 21.72.03.6-1.7-1.9-1.11.9-1.7-1.61.61.5-1.71.61.61.41.51.50.81.21.20.80.80.80.7
Locomotion distance, session 21.42.02.8-1.4-1.4-0.61.4-1.5-1.61.61.7-1.51.61.61.51.51.51.01.51.31.11.11.41.1
Locomotion velocity, session 30.10.10.3-0.4-0.3-0.50.2-0.2-0.30.40.4-0.10.10.10.10.10.1-0.20.1-0.1-0.1-0.2-0.2-0.2
Locomotion distance, session 30.40.40.9-0.20.6-0.8-0.60.20.0-0.00.00.5-0.4-0.5-0.4-0.6-0.6-0.8-0.7-0.8-0.9-0.9-1.0-0.9
Stereotopy head waving bouts, day 30.40.51.3-0.9-1.1-0.71.1-0.8-0.80.70.8-0.70.70.70.60.60.70.10.50.40.30.20.30.1
Stereotopy head waving duration, day 30.00.10.5-0.1-0.7-0.10.7-0.00.1-0.1-0.1-0.00.10.1-0.00.10.1-0.3-0.00.0-0.0-0.10.1-0.2
Locomotion velocity, session 72.22.43.5-0.9-1.10.31.0-1.5-1.51.51.5-1.71.71.71.81.71.71.61.81.81.71.71.71.9
Locomotion distance, session 71.31.62.5-0.8-0.70.10.6-1.3-1.31.31.3-1.31.41.41.51.51.51.01.41.51.41.41.41.6
Stereotopy head waving bouts, day 70.40.50.70.70.70.3-0.70.70.8-0.7-0.80.9-0.8-0.7-0.6-0.8-0.7-0.7-0.6-0.6-0.6-0.6-0.4-0.6
Stereotopy head waving duration, day 70.40.50.91.00.70.7-0.70.80.9-0.8-0.90.8-0.8-0.8-0.6-0.7-0.7-0.2-0.4-0.5-0.3-0.3-0.1-0.3
Locomotion velocity, session 80.20.31.2-0.3-0.1-0.80.10.10.00.00.00.4-0.3-0.4-0.5-0.5-0.4-0.7-0.5-0.7-0.8-0.8-0.7-1.1
Locomotion distance, session 80.40.63.0-1.2-0.9-1.71.0-0.5-0.60.60.60.10.20.2-0.0-0.10.1-1.2-0.4-0.5-0.9-1.0-0.8-1.2
Degree of sensitization distance1.81.93.6-0.2-0.81.00.8-1.0-0.90.80.8-1.31.31.41.41.51.51.51.61.81.81.91.81.9
Degree of sensitization stereotypy0.60.60.90.70.90.2-0.90.90.8-0.8-0.81.0-0.9-0.9-0.8-0.9-0.9-0.7-0.7-0.8-0.7-0.7-0.6-0.8
Conditioned locomotion0.00.00.30.00.20.1-0.2-0.00.0-0.1-0.10.10.10.20.00.10.3-0.5-0.10.2-0.00.10.20.2
Cocaine response after cond. corrected1.51.82.7-0.7-0.90.41.0-1.1-1.31.41.3-1.31.41.51.31.51.61.21.61.61.51.61.51.3
Cocaine response after cond. not corrected2.32.75.7-0.0-0.61.50.7-0.8-1.11.21.1-1.51.51.51.41.71.72.02.12.12.32.32.42.1
Cocaine response before conditioning0.50.61.90.70.31.4-0.30.10.1-0.2-0.2-0.40.20.20.30.40.31.30.80.81.21.11.41.3
Saline control response0.30.50.80.20.5-0.4-0.50.40.6-0.7-0.70.6-0.7-0.7-0.7-0.7-0.8-0.7-0.8-0.8-0.8-0.8-0.8-0.9
Bone: connectivity density0.10.20.50.60.40.4-0.30.60.4-0.4-0.30.4-0.6-0.6-0.5-0.5-0.70.2-0.3-0.4-0.1-0.2-0.3-0.5
Bone: cortical apparent density3.24.410.6-3.3-2.1-2.82.1-2.7-2.82.82.8-2.22.32.32.12.02.10.11.51.20.60.40.50.5
Bone: cortical area0.91.42.4-0.7-1.50.21.5-1.1-1.01.01.0-1.21.21.31.21.31.40.91.21.41.31.21.21.3
Bone: cortical porosity1.41.63.01.51.60.9-1.71.41.4-1.4-1.31.2-1.4-1.5-1.2-1.3-1.5-0.1-1.1-1.1-0.8-0.7-0.9-0.8
Bone: cortical porosity1.11.22.91.71.51.5-1.61.41.3-1.4-1.31.0-1.2-1.2-0.9-1.0-1.20.5-0.7-0.6-0.2-0.1-0.3-0.1
Bone: cortical thickness0.91.53.9-1.8-2.0-1.62.0-1.5-1.41.41.5-1.11.21.31.01.01.2-0.30.70.70.30.10.20.2
Bone: cortical thickness0.30.40.7-0.3-0.50.20.5-0.5-0.50.60.6-0.70.70.70.70.70.70.60.80.70.80.70.60.7
Bone: cortical tissue density3.14.210.1-3.2-2.0-2.72.1-2.7-2.72.82.8-2.22.32.32.11.92.10.21.51.20.60.40.50.5
Condit. Reinf. active minus inactive responses2.42.76.42.52.22.3-2.22.12.1-2.2-2.11.8-1.7-1.6-1.5-1.4-1.2-0.9-1.1-0.7-0.3-0.2-0.20.2
Condit. Reinf. active-inactive response ratio1.61.73.71.91.71.7-1.81.51.7-1.8-1.71.4-1.4-1.2-1.1-1.1-1.0-0.8-0.9-0.6-0.3-0.2-0.20.2
Condit. Reinf. active responses1.21.45.52.11.62.4-1.61.51.5-1.5-1.51.1-1.1-0.9-0.9-0.7-0.6-0.2-0.5-0.00.30.50.40.8
Condit. Reinf. inactive responses0.30.30.7-0.1-0.50.50.6-0.3-0.40.50.5-0.50.60.60.40.70.80.50.60.80.70.80.70.8
Incentive salience index mean2.42.95.82.42.21.9-2.22.12.2-2.2-2.21.9-1.9-1.8-1.7-1.6-1.5-0.9-1.4-1.1-0.7-0.6-0.6-0.3
Condit. Reinf. lever presses1.52.12.71.41.50.6-1.51.61.6-1.6-1.61.6-1.6-1.6-1.6-1.5-1.5-1.3-1.5-1.4-1.3-1.2-1.1-1.2
Condit. Reinf. active minus inactive responses0.91.25.42.01.22.3-1.31.41.4-1.4-1.40.8-0.9-0.8-0.6-0.5-0.50.4-0.10.10.60.60.80.8
Condit. Reinf. active-inactive response ratio1.41.64.12.01.51.8-1.61.71.7-1.7-1.71.3-1.4-1.4-1.2-1.2-1.2-0.2-0.8-0.7-0.2-0.2-0.1-0.1
Condit. Reinf. active responses0.30.42.00.9-0.01.4-0.00.40.5-0.4-0.40.0-0.00.10.10.20.20.60.50.60.90.91.00.9
Condit. Reinf. inactive responses0.81.11.5-0.5-1.20.31.2-0.9-0.80.80.8-1.11.11.11.11.11.11.11.21.21.21.21.21.1
Condit. Reinf. lever presses0.00.10.20.3-0.50.40.40.00.2-0.2-0.2-0.1-0.1-0.10.20.0-0.10.40.10.10.30.20.30.3
Condit. Reinf. lever reinforcers received0.40.51.90.7-0.31.40.20.10.2-0.2-0.2-0.30.20.30.40.50.50.80.70.91.11.11.21.1
Conditioned reinforcement - actives0.00.10.2-0.4-0.1-0.40.2-0.3-0.40.30.3-0.20.30.30.20.30.3-0.00.10.2-0.00.00.20.1
Conditioned reinforcement - inactives0.10.10.50.00.10.4-0.2-0.2-0.20.40.4-0.20.30.30.30.30.40.40.50.50.50.50.70.6
Conditioned locomotion3.14.05.7-2.0-1.6-0.81.8-2.2-2.42.32.3-2.42.32.22.12.22.12.22.02.01.71.71.51.6
Patch foraging indifference point 0 sec1.32.58.9-2.4-3.0-2.42.6-2.2-1.91.71.7-1.61.41.21.61.00.80.80.60.2-0.1-0.2-0.5-0.0
Patch foraging indifference point AUC0.91.34.3-0.6-1.20.10.9-1.3-1.00.90.8-1.51.11.01.61.20.82.11.21.11.11.30.91.3
Delay disc. indifference point, 0s delay0.00.00.2-0.0-0.3-0.00.2-0.2-0.10.20.2-0.10.0-0.00.30.0-0.10.40.2-0.10.00.00.2-0.1
Delay disc. indifference point, 16s delay0.60.61.10.90.80.6-0.90.91.0-1.0-1.10.9-0.8-0.7-0.9-0.7-0.6-0.9-0.8-0.5-0.5-0.4-0.4-0.5
Delay disc. indifference point, 2s delay0.10.10.4-0.1-0.30.10.2-0.1-0.30.30.3-0.40.20.20.10.20.10.60.60.20.50.30.30.2
Delay disc. indifference point, 24s delay0.60.72.50.20.6-0.5-0.70.50.6-0.6-0.70.9-0.7-0.6-0.7-0.8-0.5-1.6-1.0-0.8-1.0-1.0-1.1-1.0
Delay disc. indifference point, 4s delay0.30.30.8-0.7-0.9-0.60.6-0.7-0.60.70.7-0.40.50.40.60.40.40.10.50.20.20.0-0.0-0.2
Delay disc. indifference point, 8s delay0.10.10.40.60.40.7-0.60.20.5-0.4-0.50.3-0.3-0.2-0.1-0.1-0.0-0.30.10.10.20.10.30.2
Indifference point function ln k0.71.24.1-0.30.2-1.3-0.30.60.4-0.3-0.41.0-0.8-0.8-1.1-1.0-0.8-2.0-1.2-1.3-1.5-1.6-1.1-2.0
Indifference point function log k0.71.24.1-0.30.2-1.3-0.30.60.4-0.3-0.41.0-0.8-0.8-1.1-1.0-0.8-2.0-1.2-1.3-1.5-1.6-1.1-2.0
Patch foraging total patch changes 0 sec1.32.58.9-2.4-3.0-2.42.6-2.2-1.91.81.7-1.71.41.11.71.00.71.00.60.3-0.0-0.1-0.4-0.0
Patch foraging total patch changes 12 sec0.91.23.3-0.9-1.8-0.41.5-1.4-1.00.90.8-1.31.00.91.51.00.61.60.80.70.70.80.41.0
Patch foraging total patch changes 18 sec0.81.23.7-1.5-1.9-1.41.7-1.5-1.31.11.1-1.41.10.91.30.90.51.20.70.30.20.2-0.10.3
Patch foraging total patch changes 24 sec0.61.03.6-1.1-1.9-0.81.6-1.2-1.11.01.0-1.30.90.71.10.80.51.40.80.40.50.40.20.5
Patch foraging total patch changes 6 sec1.82.88.3-2.3-2.9-2.12.6-2.3-2.01.91.9-1.91.61.41.91.30.91.40.90.60.40.3-0.20.3
Patch foraging time to switch 0 sec0.40.91.71.21.30.9-1.21.21.1-1.2-1.11.3-1.0-0.9-1.0-0.9-0.7-0.8-0.8-0.5-0.4-0.4-0.4-0.1
Patch foraging water rate 0 sec0.30.61.4-1.2-1.0-1.01.1-0.9-1.01.01.0-1.00.80.80.60.70.70.30.60.40.20.20.3-0.3
Patch foraging water rate 12 sec0.20.41.4-0.30.1-0.9-0.20.20.1-0.0-0.10.4-0.3-0.3-0.7-0.4-0.3-1.0-0.6-0.7-0.9-0.9-1.0-1.2
Patch foraging water rate 18 sec0.71.13.00.31.0-0.5-1.00.90.8-0.8-0.91.1-1.0-0.9-1.3-1.1-0.8-1.7-1.2-1.1-1.2-1.3-1.1-1.5
Patch foraging water rate 24 sec0.00.00.1-0.0-0.10.20.30.2-0.10.00.1-0.10.20.3-0.30.20.4-0.30.10.30.30.20.1-0.2
Patch foraging water rate 6 sec0.50.73.0-0.7-0.0-1.50.10.1-0.10.10.10.4-0.4-0.3-0.8-0.6-0.5-1.4-0.7-1.0-1.3-1.3-1.1-1.7
Seeking ratio, delayed vs. immediate footshock0.60.73.71.51.01.9-0.70.91.0-1.1-1.10.4-0.5-0.5-0.2-0.3-0.40.90.10.20.60.70.80.7
Distance traveled before self-admin1.11.56.62.21.62.6-1.41.51.4-1.3-1.40.8-1.0-1.0-0.6-0.7-0.91.2-0.20.00.50.70.40.6
Distance traveled after self-admin0.50.62.21.31.21.5-1.10.80.8-0.8-0.80.6-0.6-0.6-0.4-0.4-0.40.40.10.00.30.40.40.6
Extensor digitorum longus weight6.625.935.4-5.8-5.8-3.15.8-5.9-6.05.95.9-5.75.95.85.45.55.73.14.94.73.83.53.43.0
Bone: elastic displacement2.12.53.51.01.4-0.2-1.51.31.4-1.4-1.41.8-1.7-1.7-1.4-1.8-1.7-1.7-1.8-1.8-1.8-1.7-1.9-1.6
Bone: elastic work0.60.82.11.51.41.4-1.41.01.1-1.1-1.10.8-0.9-0.9-0.6-0.7-0.80.1-0.5-0.3-0.00.1-0.00.1
Bone: endosteal estimation0.92.010.42.00.53.2-0.50.60.8-0.8-0.9-0.30.00.00.40.50.32.41.01.31.82.11.92.1
Bone: endosteal perimeter0.30.73.81.20.22.0-0.20.40.5-0.6-0.6-0.00.00.10.10.30.31.00.50.91.01.21.11.3
Epididymis fat weight0.62.25.10.2-0.31.70.1-0.7-0.70.60.6-1.31.21.41.31.61.61.51.82.02.22.22.32.3
Delta time in closed arm before/after self-admin0.40.30.8-0.8-0.9-0.60.6-0.7-0.60.80.8-0.70.60.60.50.50.50.30.70.30.30.20.10.3
Delta time in open arm before/after self-admin1.61.64.42.12.12.1-1.81.51.5-1.4-1.51.1-1.2-1.2-0.8-1.0-1.10.6-0.7-0.4-0.00.20.20.1
Diff in mean of infusions in LGA sessions0.70.81.61.21.11.0-1.11.21.1-1.2-1.11.0-1.0-0.9-1.0-0.9-0.8-0.5-0.9-0.6-0.5-0.3-0.5-0.2
Delay discount exponential model param0.00.00.3-0.0-0.00.10.3-0.0-0.10.10.1-0.20.20.10.10.20.10.50.10.20.20.30.10.4
Extinction: sum of active levers before priming0.80.91.91.20.70.8-0.71.11.2-1.4-1.31.2-1.1-1.0-0.9-0.9-0.8-0.8-0.8-0.7-0.7-0.5-0.3-0.2
Active lever presses in extinction session 61.11.02.91.21.70.8-1.71.11.1-1.3-1.21.0-1.1-1.0-0.9-1.0-1.0-0.6-0.9-0.8-0.6-0.50.1-0.6
Bone: final force1.01.73.80.2-0.71.50.8-0.5-0.60.60.6-1.11.01.11.11.31.21.91.51.71.91.91.91.7
Bone: final moment0.91.42.8-0.0-1.01.11.0-0.6-0.70.60.7-1.11.11.11.01.31.21.61.31.51.61.71.61.4
Food consumed during 24 hour testing period0.50.72.70.30.21.1-0.2-0.3-0.30.30.3-0.80.60.60.70.80.61.71.01.01.11.31.21.4
Glucose1.21.94.00.10.5-1.2-0.50.90.9-0.9-0.91.3-1.3-1.3-1.5-1.5-1.4-1.8-1.7-1.8-1.8-1.9-2.0-1.8
Heart weight0.10.10.50.40.30.7-0.30.10.2-0.4-0.4-0.0-0.0-0.00.10.10.00.30.10.20.30.40.10.2
Delay discount hyperbolic model param0.00.00.20.10.10.20.10.1-0.00.00.1-0.20.10.1-0.00.10.10.50.00.20.20.30.20.4
Intermittent access intake day 1-15 change0.10.21.0-0.7-0.9-0.90.2-1.0-0.30.20.2-0.30.30.30.60.20.3-0.7-0.1-0.1-0.3-0.3-0.30.0
Intermittent access intake escalation0.20.41.6-1.0-1.2-1.30.5-1.2-0.40.20.2-0.20.30.30.70.10.2-0.9-0.3-0.3-0.6-0.6-0.6-0.3
Intermittent access intake escalation 20.40.41.4-0.1-0.4-0.8-0.3-0.20.3-0.4-0.50.5-0.5-0.5-0.1-0.6-0.5-1.2-0.9-0.9-1.0-1.0-0.7-0.7
Intermitt. access day 1 inactive lever presses0.31.05.6-1.6-1.3-2.41.0-0.9-0.50.50.5-0.00.20.10.1-0.2-0.1-1.2-0.7-0.8-1.3-1.3-1.2-1.0
Intermitt. access day 15 inactive lever presses0.00.10.4-0.5-0.1-0.60.20.0-0.30.40.50.10.20.1-0.2-0.00.2-0.5-0.3-0.0-0.3-0.3-0.3-0.3
Intermitt. access escalation Index0.40.52.8-0.20.0-0.7-0.30.20.4-0.5-0.50.7-0.4-0.3-0.7-0.6-0.3-1.7-0.8-0.7-0.8-1.0-1.0-1.0
Intermittent access day 1 total infusions0.40.71.30.70.50.1-0.51.00.8-0.7-0.71.2-1.0-1.0-1.1-1.0-0.9-1.0-0.9-0.9-1.0-0.9-0.6-0.7
Intermittent access day 15 total infusions0.50.73.1-0.8-0.9-1.60.4-0.4-0.1-0.0-0.00.5-0.3-0.3-0.2-0.5-0.3-1.8-0.8-0.9-1.3-1.3-1.1-0.9
Intermittent access terminal intake (last 3 days)0.50.73.3-1.0-1.0-1.80.5-0.4-0.30.20.20.3-0.1-0.2-0.3-0.4-0.2-1.6-0.7-0.9-1.3-1.3-0.8-0.9
Intermittent access total infusions0.30.41.3-0.1-0.3-0.70.10.30.1-0.1-0.10.7-0.5-0.5-0.6-0.6-0.5-1.1-0.6-0.8-1.0-1.0-0.7-0.8
Intermittent access day 1 locomotion0.00.00.1-0.10.3-0.0-0.10.2-0.30.20.30.00.10.1-0.20.10.10.00.20.10.00.0-0.10.0
Intermittent access day 15 total locomotion0.51.01.7-0.9-0.9-0.40.9-1.0-1.31.31.3-1.01.11.11.11.11.10.71.11.00.80.80.60.7
Intermittent access total locomotion0.30.31.0-0.9-0.8-1.00.8-0.5-0.90.80.8-0.30.50.50.30.30.4-0.10.30.1-0.2-0.2-0.3-0.3
Intermittent access standard deviation0.20.41.4-0.7-1.2-0.60.6-1.1-0.80.70.7-0.70.50.50.80.50.40.10.40.20.30.10.30.2
Left kidney weight0.10.20.70.50.50.4-0.60.40.6-0.8-0.80.6-0.5-0.4-0.4-0.4-0.4-0.5-0.6-0.3-0.4-0.3-0.2-0.2
Right kidney weight0.20.71.4-0.8-1.0-0.20.9-1.2-0.80.50.5-1.01.01.01.11.01.10.70.71.00.70.80.60.6
Cocaine induced anxiety0.60.82.1-1.5-0.8-1.30.9-1.2-1.21.31.3-0.91.01.00.80.80.9-0.00.60.50.30.10.1-0.0
Post-drug Anxiety1.31.42.5-1.5-1.3-1.01.4-1.5-1.51.61.6-1.21.41.41.11.21.30.41.01.00.80.60.40.5
Baseline Anxiety0.30.41.61.10.41.3-0.40.60.9-0.8-0.80.4-0.5-0.5-0.3-0.3-0.30.2-0.10.00.20.30.60.5
Tail length1.76.817.34.23.94.0-3.73.43.3-3.3-3.32.7-2.5-2.4-2.3-2.0-1.9-0.5-1.6-0.8-0.30.1-0.50.2
Length with tail1.45.927.64.33.75.3-3.52.82.7-2.8-2.81.7-1.6-1.4-1.3-0.9-0.91.0-0.30.61.31.70.91.9
Length without tail0.82.710.51.60.83.2-0.90.10.1-0.3-0.3-0.80.60.71.01.10.92.51.51.92.42.71.92.7
Times rat made contact with spout2.12.43.80.71.1-0.6-1.01.31.3-1.3-1.31.7-1.6-1.7-1.7-1.8-1.8-1.7-1.9-1.9-1.9-1.9-1.9-1.7
Lifetime Intake0.20.20.8-0.6-0.8-0.90.7-0.2-0.50.50.50.10.10.0-0.0-0.1-0.0-0.6-0.1-0.3-0.5-0.6-0.3-0.3
Liver weight, left0.40.72.40.70.21.5-0.2-0.10.1-0.1-0.1-0.50.40.40.40.70.61.30.91.11.21.41.31.1
Liver weight, right0.10.21.20.70.41.1-0.50.30.4-0.5-0.5-0.1-0.0-0.0-0.10.10.10.60.20.40.60.70.40.6
Locomotor activity0.00.00.2-0.2-0.5-0.10.4-0.2-0.10.20.1-0.20.20.20.10.10.10.10.20.10.20.10.10.1
Locomotor testing distance0.30.50.90.50.3-0.1-0.40.60.8-0.7-0.80.7-0.8-0.9-0.7-0.8-0.9-0.5-0.8-0.9-0.7-0.8-0.8-0.7
Locomotor testing rearing0.61.23.3-0.10.1-1.1-0.30.60.7-0.8-0.81.1-0.9-0.9-1.0-1.1-1.0-1.8-1.4-1.4-1.5-1.6-1.5-1.3
Locomotion in novel chamber3.74.77.4-1.8-2.1-0.42.0-2.5-2.22.22.1-2.62.42.32.72.42.22.42.32.21.92.02.01.9
Locomotion in novel chamber post-restriction2.64.36.4-1.8-2.2-0.52.5-2.0-2.42.42.4-2.32.32.22.22.22.22.12.22.11.91.81.71.3
Fecal boli incidents, locomotor time 10.10.20.80.20.9-0.1-0.80.60.3-0.3-0.30.3-0.4-0.5-0.6-0.5-0.5-0.1-0.4-0.5-0.4-0.4-0.5-0.2
Change in fecal boli incidents, locomotor task0.20.20.7-0.2-0.3-0.50.10.0-0.0-0.1-0.10.3-0.2-0.2-0.3-0.3-0.2-0.7-0.5-0.3-0.5-0.5-0.8-0.9
Time >=10cm from walls, locomotor time 11.31.42.5-0.6-1.30.31.0-1.2-0.90.80.8-1.31.21.21.61.31.31.21.11.31.31.31.21.6
Bouts of movement, locomotor time 10.40.41.4-1.1-1.0-1.21.0-0.6-0.90.91.0-0.50.60.60.20.40.5-0.20.30.1-0.1-0.20.0-0.2
Total resting periods, locomotor time 10.80.92.2-1.5-1.3-1.31.3-1.0-1.31.31.3-0.91.01.00.60.80.90.10.70.50.20.10.30.1
Rest time, locomotor task time 10.30.41.0-0.5-0.2-1.00.10.20.0-0.1-0.10.3-0.2-0.3-0.7-0.4-0.4-0.8-0.8-0.7-1.0-0.9-1.0-0.9
Distance moved, locomotor task time 10.10.20.60.60.30.5-0.30.30.6-0.5-0.60.6-0.4-0.3-0.1-0.3-0.2-0.7-0.3-0.2-0.1-0.2-0.2-0.2
Vertical activity count, locomotor time 10.00.00.20.0-0.20.20.1-0.3-0.0-0.00.0-0.10.10.10.50.10.2-0.00.20.20.20.20.30.1
Time >=10cm from walls, locomotor time 20.91.32.51.41.20.9-1.41.11.4-1.6-1.61.3-1.3-1.3-0.9-1.2-1.2-0.7-1.2-0.9-0.8-0.6-0.7-0.7
Bouts of movement, locomotor time 21.11.74.5-2.1-1.9-2.01.7-1.6-1.71.61.6-1.11.41.41.11.11.3-0.40.80.70.20.00.2-0.2
Total resting periods, locomotor time 20.91.64.4-2.1-1.9-2.01.7-1.6-1.71.51.6-1.11.31.31.11.01.2-0.30.70.60.1-0.10.1-0.3
Rest time, locomotor task time 20.30.42.0-0.9-0.5-1.40.5-0.4-0.50.40.5-0.20.1-0.0-0.1-0.1-0.3-0.2-0.4-0.5-0.8-0.7-1.0-0.8
Distance moved, locomotor task time 20.20.21.00.80.31.0-0.20.30.6-0.6-0.60.4-0.3-0.1-0.0-0.10.1-0.30.00.20.40.30.50.4
Vertical activity count, locomotor time 20.10.10.7-0.0-0.0-0.2-0.00.00.2-0.3-0.30.3-0.2-0.1-0.1-0.2-0.0-0.8-0.4-0.2-0.3-0.40.0-0.4
Light reinforcement 12.76.511.1-3.3-3.1-2.42.9-3.2-3.23.23.0-3.02.92.82.82.62.51.62.11.91.31.21.21.3
Light reinforcement 20.60.92.1-1.3-0.7-0.90.7-1.2-1.31.51.4-1.21.11.01.10.90.81.00.80.70.60.50.30.3
Bone: marrow area0.91.99.61.90.43.1-0.40.60.7-0.7-0.8-0.30.10.10.50.60.32.41.01.31.82.11.92.0
Bone: maximum diameter0.20.31.2-0.3-1.00.11.1-0.4-0.30.30.3-0.40.50.60.40.60.70.10.40.60.40.50.40.5
Bone: maximum force1.52.67.00.6-0.52.20.6-0.5-0.50.40.5-1.31.11.21.31.51.32.71.82.02.42.52.42.2
Bone: maximum moment1.22.15.60.3-0.81.70.8-0.6-0.60.60.6-1.31.11.11.21.41.22.41.71.82.12.22.11.8
Mean time between licks in bursts1.43.46.3-2.0-2.5-1.12.4-2.3-2.12.12.0-2.22.01.92.01.91.81.61.61.51.11.21.20.9
Mean num. licks in bursts0.20.30.6-0.2-0.40.20.4-0.5-0.40.40.4-0.50.50.40.60.50.40.80.60.50.60.60.60.6
Cd content in liver2.22.54.01.91.81.2-1.82.01.9-1.9-1.91.9-1.8-1.7-1.7-1.6-1.4-1.5-1.4-1.2-1.0-1.0-0.8-0.7
Co content in liver2.52.94.71.21.50.1-1.51.71.7-1.7-1.72.0-1.8-1.7-1.9-1.8-1.6-2.2-2.0-1.7-1.9-1.7-1.8-1.6
Cu content in liver1.61.92.91.61.70.9-1.71.71.6-1.6-1.61.6-1.5-1.5-1.4-1.4-1.3-1.1-1.3-1.2-1.0-0.9-0.5-0.8
Fe content in liver3.44.15.52.02.20.8-2.22.22.3-2.3-2.32.3-2.3-2.3-2.1-2.3-2.3-1.4-2.1-2.1-1.8-1.7-1.3-1.6
K content in liver2.22.13.6-1.5-1.7-0.81.7-1.7-1.51.61.6-1.81.51.41.81.41.11.91.31.11.01.00.71.1
Mg content in liver0.30.30.8-0.7-0.9-0.60.9-0.6-0.50.60.6-0.60.50.30.70.30.10.80.30.10.10.1-0.10.2
Mn content in liver0.20.21.0-0.6-0.6-1.00.6-0.2-0.30.50.50.0-0.1-0.1-0.0-0.2-0.3-0.2-0.1-0.5-0.5-0.7-0.7-0.8
Na content in liver0.00.00.20.20.00.1-0.00.10.2-0.2-0.2-0.0-0.2-0.30.0-0.2-0.40.5-0.2-0.2-0.2-0.1-0.2-0.1
Rb content in liver3.74.36.2-2.1-2.3-0.92.2-2.4-2.22.22.3-2.22.42.42.42.32.51.12.02.11.61.61.61.8
Se content in liver0.10.10.3-0.5-0.3-0.40.2-0.5-0.30.40.3-0.50.40.40.50.40.30.30.20.20.20.20.10.1
Sr content in liver0.10.10.3-0.4-0.3-0.60.3-0.2-0.20.20.20.00.00.00.1-0.10.0-0.4-0.2-0.2-0.3-0.3-0.2-0.2
Zn content in liver0.00.00.2-0.1-0.4-0.20.4-0.1-0.10.00.0-0.10.10.10.10.10.1-0.0-0.00.0-0.0-0.0-0.00.1
Bone: minimum diameter1.01.83.70.1-1.21.31.2-0.7-0.80.80.8-1.21.11.11.21.41.21.91.71.61.91.91.81.7
Time in familiar zone, hab. session 10.40.41.4-0.30.2-0.9-0.20.10.2-0.1-0.20.5-0.3-0.3-0.4-0.5-0.4-1.2-0.7-0.7-0.9-0.9-0.9-1.0
Time in novel zone, hab. session 12.22.24.62.11.91.8-1.91.91.9-1.9-1.91.5-1.6-1.6-1.4-1.4-1.5-0.2-1.1-0.9-0.5-0.4-0.4-0.3
Total zone transitions, hab. session 11.01.42.7-0.2-0.20.90.3-0.9-1.00.91.0-1.21.11.21.21.31.21.61.41.51.61.61.51.6
Total locomotion distance, hab. session 12.43.37.90.1-0.71.80.7-1.0-1.11.11.1-1.81.61.61.61.91.72.82.22.32.62.72.62.3
Locomotion velocity, hab. session 13.04.37.9-0.7-1.51.01.5-1.6-1.71.71.7-2.32.02.02.02.32.12.82.52.52.62.62.62.3
Time in familiar zone, hab. session 20.20.30.40.20.5-0.2-0.50.30.4-0.4-0.40.6-0.5-0.5-0.5-0.6-0.5-0.6-0.6-0.6-0.6-0.6-0.7-0.4
Time in novel zone, hab. session 20.20.20.40.20.0-0.2-0.00.50.4-0.4-0.40.5-0.4-0.4-0.6-0.5-0.4-0.6-0.5-0.5-0.5-0.5-0.5-0.4
Total zone transitions, hab. session 20.00.10.3-0.00.1-0.2-0.10.20.1-0.1-0.10.3-0.2-0.2-0.4-0.2-0.1-0.5-0.3-0.2-0.3-0.3-0.3-0.2
Total locomotion distance, hab. session 20.30.41.10.3-0.40.90.5-0.1-0.10.10.1-0.40.40.50.30.60.70.60.70.90.91.01.11.0
Locomotion velocity, hab. session 20.50.71.70.1-0.60.90.7-0.3-0.40.40.4-0.70.70.80.60.90.90.91.01.11.21.21.31.2
Novel to familiar place preference ratio0.91.02.11.41.21.2-1.21.21.4-1.4-1.41.0-1.1-1.1-0.8-0.9-1.0-0.2-0.7-0.6-0.4-0.3-0.3-0.1
Novelty place preference1.11.22.21.31.10.8-1.11.31.5-1.5-1.51.2-1.2-1.2-1.0-1.1-1.2-0.6-1.0-0.9-0.7-0.6-0.7-0.5
Time in novel zone, NPP test1.41.52.71.51.20.9-1.21.41.6-1.6-1.61.4-1.4-1.4-1.2-1.3-1.3-0.8-1.2-1.0-0.8-0.7-0.8-0.6
Total zone transitions, NPP test0.20.40.7-0.8-0.5-0.60.6-0.7-0.80.80.8-0.40.70.70.40.60.8-0.40.50.50.20.20.40.3
Total locomotion distance, NPP test0.60.81.7-0.1-0.60.70.6-0.4-0.70.70.7-0.90.80.80.70.90.81.31.11.01.21.21.31.0
Locomotion velocity, NPP test0.81.22.1-0.5-0.90.31.0-0.8-1.01.11.1-1.21.11.11.01.21.01.51.31.21.31.21.31.0
Intraocular pressure0.10.20.9-0.4-0.4-0.80.4-0.0-0.10.10.10.3-0.2-0.1-0.3-0.3-0.1-1.0-0.3-0.5-0.5-0.7-0.9-0.6
Delta distance traveled before/after self-admin0.10.10.6-0.6-0.2-0.70.2-0.4-0.50.30.4-0.10.30.40.00.20.4-0.80.10.1-0.1-0.20.2-0.1
Delta ambulatory time before/after self-admin0.20.30.8-0.9-0.7-0.80.6-0.7-0.70.60.6-0.40.50.60.40.50.6-0.60.50.30.1-0.10.50.1
Parametrial fat weight0.20.51.8-1.0-0.8-1.40.8-0.2-0.50.40.5-0.00.20.2-0.3-0.00.1-0.8-0.5-0.3-0.7-0.7-1.1-1.2
Pavlov. Cond. lever latency2.93.64.7-2.1-2.0-1.12.0-2.2-2.22.22.2-2.12.22.12.12.12.11.32.01.81.51.41.71.3
Pavlov. Cond. magazine entry latency2.22.85.92.32.41.9-2.42.12.1-2.0-2.11.7-1.8-1.8-1.7-1.5-1.6-0.5-1.2-1.1-0.7-0.5-0.6-0.3
Pavlov. Cond. change in total contacts1.92.03.41.81.41.2-1.51.71.8-1.8-1.91.7-1.6-1.5-1.6-1.4-1.3-1.1-1.4-1.1-0.9-0.7-1.0-0.6
Pavlov. Cond. index score3.44.35.92.32.31.3-2.42.42.4-2.4-2.42.3-2.4-2.3-2.3-2.2-2.2-1.4-2.0-1.8-1.6-1.4-1.6-1.3
Pavlov. Cond. latency score3.24.15.92.32.41.4-2.42.42.4-2.4-2.42.2-2.3-2.3-2.2-2.1-2.1-1.2-1.9-1.7-1.4-1.2-1.5-1.1
Pavlov. Cond. lever contacts3.03.64.61.91.80.9-1.92.12.1-2.1-2.12.2-2.1-2.1-2.1-2.1-2.0-1.4-2.0-1.8-1.6-1.5-1.7-1.4
Pavlov. Cond. magazine entry number3.44.37.6-2.7-2.8-1.92.7-2.5-2.62.52.6-2.32.32.22.22.02.01.11.81.51.10.91.10.8
Pavlov. Cond. intertrial magazine entries0.10.10.4-0.3-0.6-0.10.6-0.3-0.30.30.3-0.20.40.40.30.40.5-0.20.30.40.30.20.20.2
Pavlov. Cond. lever-magazine prob. diff.2.83.54.92.22.11.3-2.22.22.2-2.2-2.22.1-2.1-2.1-2.1-2.0-1.9-1.2-1.8-1.6-1.3-1.2-1.4-1.0
Pavlov. Cond. response bias3.54.36.22.42.51.5-2.52.42.5-2.5-2.52.3-2.3-2.3-2.2-2.1-2.1-1.3-1.9-1.7-1.4-1.2-1.4-1.1
Pavlov. Cond. lever latency0.10.10.5-0.50.1-0.70.0-0.2-0.30.30.30.00.20.2-0.10.00.2-0.7-0.1-0.1-0.4-0.4-0.3-0.5
Pavlov. Cond. magazine entry latency0.10.10.60.70.00.8-0.10.40.4-0.4-0.40.1-0.3-0.3-0.1-0.2-0.30.40.0-0.00.30.20.30.3
Pavlov. Cond. change in total contacts0.30.51.71.20.71.3-0.80.90.9-1.0-1.00.5-0.7-0.7-0.4-0.5-0.70.6-0.2-0.20.20.30.10.4
Pavlov. Cond. index score0.20.31.30.8-0.01.2-0.10.30.4-0.5-0.5-0.1-0.2-0.20.20.0-0.20.90.20.30.60.60.50.7
Pavlov. Cond. latency score0.30.31.40.7-0.11.2-0.00.10.2-0.3-0.3-0.30.00.00.40.20.01.20.50.50.80.80.80.9
Pavlov. Cond. lever contacts0.20.30.90.90.20.9-0.30.60.7-0.7-0.70.3-0.5-0.6-0.3-0.4-0.60.5-0.3-0.20.10.10.00.2
Pavlov. Cond. magazine entry number0.20.20.8-0.9-0.4-0.90.4-0.6-0.60.60.6-0.30.50.50.20.40.6-0.50.20.2-0.2-0.1-0.1-0.2
Pavlov. Cond. intertrial magazine entries0.20.31.3-1.0-0.7-1.20.8-0.5-0.70.60.7-0.30.50.50.20.30.4-0.60.00.0-0.2-0.3-0.2-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.20.90.6-0.20.90.10.10.2-0.3-0.3-0.2-0.0-0.00.30.1-0.10.90.30.30.60.60.50.7
Pavlov. Cond. response bias0.30.42.11.20.31.4-0.30.70.7-0.7-0.70.2-0.5-0.5-0.1-0.3-0.51.00.10.10.50.50.50.7
Time in closed arm before self-admin0.81.02.81.71.51.7-1.31.21.2-1.5-1.20.8-1.0-1.0-0.7-0.8-1.00.5-0.8-0.40.00.2-0.2-0.2
Time in closed arm after self-admin0.10.10.50.50.30.7-0.40.10.2-0.3-0.2-0.0-0.1-0.10.1-0.0-0.10.3-0.10.10.30.30.30.3
Time in open arm before self-admin1.11.22.8-1.7-1.5-1.51.2-1.4-1.21.21.2-0.91.11.30.91.01.3-0.90.90.60.20.00.10.5
Time in open arm after self-admin0.90.93.81.71.62.0-1.51.11.1-1.0-1.10.6-0.7-0.7-0.4-0.4-0.50.7-0.10.10.40.60.40.7
Bone: periosteal estimation0.71.55.21.1-0.52.30.5-0.00.1-0.1-0.2-0.70.50.60.80.90.82.01.21.51.82.01.82.0
Bone: periosteal perimeter0.10.21.40.8-0.21.20.20.30.5-0.5-0.50.2-0.10.0-0.10.10.20.30.20.50.60.70.60.8
Bone: post-yield work0.50.72.40.70.11.6-0.10.10.1-0.0-0.1-0.50.40.40.40.60.51.41.01.01.31.41.41.1
Progressive ratio test 1 active lever presses0.30.31.3-0.9-1.1-1.10.7-0.7-0.60.50.5-0.10.30.30.30.20.2-0.8-0.1-0.2-0.4-0.5-0.2-0.2
Progressive ratio test 1 breakpoint0.20.20.9-0.7-0.9-0.80.6-0.5-0.50.40.4-0.10.20.20.30.10.2-0.6-0.0-0.1-0.3-0.4-0.1-0.1
Progressive ratio test 1 inactive lever presses0.70.92.8-1.6-1.4-1.71.0-1.6-1.21.11.1-0.70.90.91.00.70.8-0.40.20.3-0.1-0.20.20.1
Progressive ratio test 2 active lever presses0.10.20.9-0.5-0.8-0.70.5-0.3-0.10.20.10.10.00.10.1-0.00.1-1.0-0.1-0.2-0.4-0.50.3-0.2
Progressive ratio test 2 breakpoint0.20.21.4-0.5-0.9-0.90.5-0.3-0.10.10.10.3-0.00.00.0-0.10.0-1.2-0.3-0.4-0.6-0.70.1-0.4
Progressive ratio test 2 inactive lever presses0.10.20.8-0.5-0.6-0.70.2-0.7-0.20.30.30.20.10.10.5-0.00.2-0.9-0.2-0.1-0.4-0.4-0.20.0
Incentive Sensitization - Responses0.20.20.90.4-0.10.20.00.40.6-0.6-0.60.7-0.5-0.4-0.4-0.5-0.3-0.9-0.5-0.4-0.5-0.40.1-0.4
Incentive Sensitization - Breakpoint0.10.21.00.3-0.3-0.00.20.30.5-0.5-0.50.6-0.4-0.3-0.3-0.4-0.2-1.0-0.5-0.4-0.5-0.50.0-0.4
Sum of active levers in priming session hrs 5-61.51.43.71.91.61.9-1.81.51.5-1.5-1.51.2-1.2-1.1-1.1-0.9-0.8-0.4-0.5-0.4-0.10.00.20.0
Progressive ratio0.81.32.3-0.9-1.3-0.11.4-1.1-1.11.21.1-1.01.31.41.21.31.50.41.21.31.11.11.11.1
Food seeking constrained by brief footshock1.11.32.3-0.6-1.10.30.7-1.1-1.00.90.9-1.21.21.21.41.31.21.01.41.31.31.31.51.4
Seeking ratio, punishment vs. effort0.10.21.00.1-0.00.4-0.2-0.3-0.20.10.1-0.50.20.10.40.30.01.00.40.30.50.50.60.6
Retroperitoneal fat weight0.31.52.3-1.2-1.4-0.51.3-1.2-1.41.41.4-1.31.41.51.11.41.50.61.11.31.11.00.70.8
Reaction time number correct0.50.92.3-1.5-1.3-1.31.2-1.2-1.21.11.1-1.11.11.10.71.01.00.10.70.60.30.20.6-0.1
Reaction time mean minus median0.61.63.92.01.71.8-1.71.81.5-1.3-1.41.2-1.4-1.4-1.1-1.1-1.40.4-0.4-0.7-0.1-0.1-0.0-0.1
Reaction time mean minus median AUC0.61.64.01.82.01.5-1.91.91.5-1.3-1.41.2-1.4-1.4-1.5-1.2-1.30.0-0.6-0.8-0.3-0.3-0.2-0.5
Reaction time num false alarms2.73.76.8-2.6-2.3-2.02.5-2.2-2.52.52.5-1.92.12.21.91.92.10.31.61.41.10.71.10.9
Reaction time num false alarms AUC3.14.88.2-2.8-2.5-1.92.7-2.5-2.82.92.8-2.32.42.42.22.22.30.91.91.71.41.01.41.1
Reaction time trials correct on left0.50.92.3-1.5-1.3-1.31.2-1.2-1.21.11.1-1.11.11.10.71.01.00.10.70.60.30.20.6-0.1
Reaction time trials on left0.50.92.2-1.5-1.3-1.21.1-1.2-1.21.11.1-1.11.11.10.71.01.00.10.70.60.30.20.6-0.0
Reaction time mean3.45.412.33.53.53.1-3.33.12.8-2.8-2.82.5-2.4-2.3-2.4-2.0-1.9-0.7-1.3-1.1-0.5-0.3-0.1-0.2
Reaction time mean AUC3.25.112.03.33.52.8-3.33.12.7-2.6-2.62.5-2.4-2.3-2.4-2.0-1.9-0.8-1.3-1.2-0.6-0.5-0.2-0.3
Median of all reaction times4.15.813.63.53.73.0-3.43.22.9-2.9-2.92.7-2.5-2.3-2.6-2.1-1.9-1.2-1.5-1.2-0.7-0.5-0.2-0.3
Reaction time omissions0.81.22.10.90.90.2-1.10.91.1-1.1-1.11.4-1.2-1.1-0.9-1.2-1.0-1.5-1.3-1.0-1.0-1.0-1.3-0.7
Reaction time false alarm rate1.41.93.7-1.7-1.6-1.21.8-1.6-1.81.91.9-1.31.51.51.51.31.40.51.21.11.00.60.70.9
Reaction time premature initiation rate0.10.10.20.20.2-0.0-0.30.30.4-0.3-0.40.3-0.4-0.4-0.3-0.4-0.4-0.3-0.2-0.4-0.3-0.3-0.10.1
Reaction time premature initiations0.00.10.4-0.5-0.4-0.60.2-0.2-0.20.20.1-0.20.10.20.10.10.1-0.30.2-0.1-0.2-0.20.20.1
Std. dev. reaction times2.34.310.53.22.92.9-2.92.92.5-2.4-2.52.1-2.2-2.2-2.0-1.8-2.00.1-0.9-1.0-0.2-0.2-0.0-0.0
Reaction time trials completed0.50.92.2-1.5-1.3-1.21.1-1.2-1.21.11.1-1.11.11.10.71.01.00.10.70.60.30.20.6-0.0
Reaction time trials AUC0.40.82.0-1.4-1.2-1.31.0-1.1-1.11.01.0-1.01.01.00.60.80.9-0.00.60.50.20.10.5-0.1
Run reversals in cocaine runway, females1.11.12.3-0.2-0.50.70.5-0.6-0.71.10.8-0.90.91.00.91.11.11.11.51.31.31.31.51.5
Run reversals in cocaine runway, males1.01.01.8-1.1-1.1-0.61.0-1.3-1.21.11.1-1.01.21.21.21.11.20.40.91.00.70.70.70.8
Latency to leave start box in cocaine runway2.42.76.7-2.6-2.0-2.32.2-1.7-2.22.32.2-1.81.81.71.21.41.40.71.10.80.40.30.2-0.2
Latency to leave start box in cocaine runway, F1.11.35.0-2.0-1.3-2.21.4-1.3-1.51.51.5-1.11.00.80.80.60.50.40.30.0-0.3-0.4-0.7-0.7
Latency to leave start box in cocaine runway, M3.02.84.2-1.8-1.7-0.81.9-1.4-1.92.02.0-1.92.02.01.21.92.00.91.81.71.51.31.50.9
Std. dev. time between licks in bursts2.12.97.5-2.7-2.3-2.62.2-2.2-2.22.32.2-1.61.71.71.51.41.5-0.11.00.70.1-0.00.1-0.2
Total sessions with >9 infusions2.42.95.0-1.9-2.0-1.12.0-1.9-2.22.22.2-2.01.81.81.81.71.61.31.71.31.21.01.31.0
Short access day 1 total inactive lever presses2.83.65.6-1.7-1.8-0.52.1-1.8-2.32.42.4-2.02.12.11.82.12.11.82.12.01.81.71.41.2
Short access day 10 total inactive lever presses0.00.00.3-0.3-0.6-0.30.3-0.3-0.1-0.00.0-0.30.20.20.10.20.20.0-0.10.10.10.00.1-0.0
Short access day 1 total infusions2.53.35.1-1.5-1.6-0.41.8-1.7-2.12.32.3-2.01.81.81.91.81.62.02.11.61.61.52.01.4
Short access day 10 total infusions0.91.14.2-0.8-0.6-1.80.40.2-0.0-0.00.00.8-0.5-0.5-0.9-0.8-0.6-2.0-1.1-1.2-1.7-1.7-1.3-1.4
Short access total infusions0.20.30.8-0.8-0.8-0.90.9-0.5-0.80.80.9-0.30.40.40.30.30.3-0.20.30.1-0.2-0.20.10.0
Short access day 1 locomotion2.73.44.9-1.7-1.8-0.61.9-1.8-2.22.22.2-2.12.02.01.92.01.91.82.01.81.61.61.71.3
Short access day 10 total locomotion0.30.51.0-1.0-1.0-0.70.9-0.8-1.00.80.8-0.80.80.80.50.80.80.20.70.60.40.40.30.3
Short access total locomotion2.42.94.8-1.9-1.7-1.01.8-1.8-2.22.22.2-1.81.91.91.71.81.81.01.81.61.21.21.11.0
One hour access (0.3 mA shock)0.30.31.9-0.1-0.1-0.5-0.20.10.3-0.5-0.50.6-0.4-0.3-0.5-0.4-0.3-1.4-0.6-0.6-0.8-0.8-0.4-0.6
Compulsive drug intake0.81.01.7-1.2-1.1-0.71.3-1.3-1.01.11.2-1.01.11.21.01.11.20.21.01.00.70.60.70.6
One hour access (shock baseline)0.30.50.80.40.3-0.1-0.60.60.5-0.8-0.80.8-0.7-0.7-0.7-0.7-0.7-0.9-0.9-0.8-0.8-0.8-0.6-0.7
Social response proportion0.40.40.90.90.90.8-0.80.80.8-0.9-0.70.8-0.6-0.6-0.5-0.5-0.4-0.4-0.6-0.2-0.3-0.1-0.10.3
Social responses0.10.10.4-0.2-0.20.10.3-0.2-0.40.30.4-0.20.30.40.20.40.5-0.00.40.40.30.30.70.5
Social time1.52.13.21.31.80.4-1.71.61.5-1.5-1.41.7-1.6-1.6-1.6-1.6-1.5-1.4-1.4-1.4-1.4-1.3-1.0-1.2
Soleus weight1.54.36.7-1.7-2.5-0.52.6-2.1-2.12.12.1-2.32.22.22.22.22.12.02.22.02.01.81.61.8
Bone: stiffness2.03.37.40.3-0.82.00.9-0.8-0.80.80.8-1.71.51.61.51.91.72.72.22.32.62.72.72.5
Tibialis anterior weight2.79.216.6-4.0-4.1-2.84.1-3.7-3.63.63.6-3.43.43.33.13.13.11.52.52.31.61.51.31.1
Time to tail flick, vehicle, before self-admin0.30.31.0-0.4-1.0-0.71.0-0.3-0.1-0.10.00.3-0.0-0.00.1-0.2-0.0-0.8-0.6-0.3-0.6-0.5-0.9-0.5
Time to tail flick, vehicle, after self-admin0.91.22.30.70.6-0.0-0.91.11.0-1.1-1.21.1-1.1-1.0-1.3-1.1-1.0-1.3-1.5-1.1-1.1-1.0-1.4-1.0
Time to tail flick, test, before self-admin2.22.33.5-1.7-1.5-0.91.7-1.8-1.81.71.7-1.51.81.81.61.71.90.61.41.51.11.11.11.1
Time to tail flick, test, after self-admin2.93.04.5-1.6-1.9-0.61.9-2.0-1.91.91.8-2.02.01.92.11.91.81.81.41.71.51.51.21.5
Delta time to tail flick, vehicle, before/after SA0.50.51.40.71.00.3-1.20.80.8-0.7-0.80.6-0.8-0.8-0.9-0.7-0.8-0.2-0.6-0.7-0.4-0.5-0.5-0.5
Delta time to tail flick, test, before/after SA0.10.10.80.3-0.10.2-0.10.20.3-0.3-0.30.0-0.3-0.5-0.1-0.3-0.70.9-0.4-0.4-0.1-0.1-0.4-0.1
Tibia length1.23.317.12.60.84.1-0.90.91.0-1.1-1.1-0.4-0.00.00.30.70.32.91.31.62.42.72.42.6
Ambulatory time before self-admin1.11.65.92.21.92.4-1.71.61.5-1.5-1.51.0-1.1-1.1-0.8-0.8-1.00.7-0.4-0.20.30.50.20.4
Ambulatory time after self-admin0.30.40.91.00.90.9-0.90.70.7-0.7-0.70.7-0.6-0.6-0.4-0.5-0.5-0.1-0.2-0.2-0.1-0.00.10.2
Bone: tissue strength0.00.00.20.20.20.2-0.20.1-0.00.10.1-0.10.0-0.0-0.10.0-0.10.40.10.10.20.20.1-0.0
Total heroin consumption2.12.53.31.41.70.5-1.71.81.6-1.7-1.71.8-1.7-1.7-1.8-1.7-1.7-1.2-1.7-1.5-1.4-1.3-1.2-1.3
Bone: trabecular number0.61.02.51.61.21.3-1.11.31.2-1.1-1.01.0-1.2-1.2-1.0-1.0-1.10.1-0.6-0.7-0.2-0.2-0.3-0.5
Bone: trabecular spacing0.71.01.8-0.8-0.6-0.10.6-1.0-1.00.90.9-1.01.21.21.11.21.30.61.01.21.01.00.91.4
Bone: trabecular thickness4.35.47.72.62.31.4-2.32.62.8-2.8-2.72.5-2.6-2.7-2.4-2.5-2.6-1.3-2.4-2.1-1.8-1.6-1.9-1.9
Bone: trabecular tissue density0.20.30.80.20.10.7-0.1-0.20.1-0.1-0.2-0.30.40.50.50.50.60.30.40.70.60.80.70.9
Water consumed over 24 hours0.10.20.7-0.5-0.1-0.90.2-0.1-0.10.10.10.1-0.1-0.2-0.2-0.3-0.3-0.4-0.4-0.5-0.6-0.6-0.8-0.4
Number of responses in last shaping day0.10.10.2-0.0-0.1-0.3-0.1-0.20.1-0.3-0.20.2-0.2-0.20.0-0.3-0.3-0.5-0.4-0.4-0.3-0.4-0.3-0.3