Hub : Genes

C9h2orf66

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	C9h2orf66	0.17	0.13	4.6e-03	0.03	0.01	0.01	0.04	6.1e-02	1.4e-01	1.6e-01	3.3e-02
2	Brain	gene expression	C9h2orf66	0.07	0.05	1.9e-06	0.07	0.06	0.06	0.07	7.6e-07	6.4e-06	4.5e-06	9.5e-07
3	OFC	gene expression	C9h2orf66	0.2	0.13	1.1e-03	0.05	0.06	0.06	0.04	2.7e-02	2.0e-02	1.4e-02	4.8e-02
4	PL	gene expression	C9h2orf66	0.06	0.04	3.4e-06	0.03	0.02	0.02	0.03	6.4e-04	3.3e-03	1.2e-03	2.3e-04
5	pVTA	gene expression	C9h2orf66	0.08	0.05	8.6e-07	0.04	0.07	0.06	0.06	3.1e-04	5.4e-06	1.9e-05	2.7e-05
6	NAcc	gene expression	C9h2orf66	0.09	0.04	7.3e-14	0.02	0.07	0.06	0.06	1.9e-04	3.0e-10	3.2e-09	4.8e-10

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	3.1	5.7	10.9	3.3	-3.1	-3.2	1.5	0.9	0.8
Area under the delay curve	0.5	0.7	1.1	-0.7	0.8	0.6	-1.0	-0.9	-0.9
BMI with tail	2.5	8.7	17.6	-4.2	3.3	3.5	-2.4	-1.7	-1.5
BMI without tail	0.1	0.5	1.7	-0.8	0.8	1.3	0.1	0.3	0.3
Body weight	1.8	7.7	10.7	2.6	-3.1	-2.6	3.3	2.6	2.5
Weight adjusted by age	0.2	0.7	1.8	1.1	-1.0	-1.4	0.4	-0.1	-0.1
Bone surface	2.8	5.5	11.1	3.3	-2.8	-3.1	1.6	1.0	0.8
Bone volume	2.7	5.3	10.6	3.2	-2.9	-3.2	1.5	0.7	0.5
Breakpoint value in progressive ratio session	0.1	0.2	0.8	0.2	-0.6	-0.9	0.2	-0.2	-0.1
Number of licking bursts	0.2	0.6	1.0	-1.0	0.6	0.5	-0.7	-0.9	-0.9
Context. condit. distance diff. score	0.7	0.8	2.4	-1.0	1.1	1.5	-0.4	0.3	0.3
Locomotion velocity, session 1	1.8	2.0	3.0	-0.9	1.6	1.7	-1.7	-1.1	-1.2
Locomotion distance, session 1	0.3	0.3	0.8	-0.3	0.8	0.9	-0.6	-0.2	-0.3
Locomotion velocity, session 2	2.0	2.4	3.6	-0.9	1.9	1.8	-1.8	-1.3	-1.4
Locomotion distance, session 2	0.1	0.1	0.3	-0.3	0.6	0.5	-0.3	-0.1	-0.1
Locomotion velocity, session 3	0.7	0.8	1.7	0.6	-0.5	-0.2	1.0	1.3	1.3
Locomotion distance, session 3	0.1	0.1	0.1	0.2	0.0	0.2	0.3	0.4	0.4
Stereotopy head waving bouts, day 3	0.5	0.6	1.8	-0.8	1.0	1.3	-0.1	0.4	0.4
Stereotopy head waving duration, day 3	0.3	0.3	0.8	0.0	0.1	0.6	0.4	0.9	0.8
Locomotion velocity, session 7	2.4	2.6	4.3	-0.8	2.1	1.6	-1.9	-1.4	-1.6
Locomotion distance, session 7	0.2	0.2	0.4	-0.3	0.5	0.3	-0.7	-0.5	-0.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.1	0.3	0.2	-0.7	-0.6	-0.7
Stereotopy head waving duration, day 7	0.1	0.1	0.2	0.5	0.1	0.3	-0.2	0.2	0.1
Locomotion velocity, session 8	2.3	2.8	5.1	-1.0	1.5	1.3	-2.3	-1.8	-1.8
Locomotion distance, session 8	0.6	0.9	2.4	-0.9	1.3	1.6	-0.7	-0.0	-0.0
Degree of sensitization distance	0.3	0.3	0.7	-0.2	0.1	-0.3	-0.7	-0.8	-0.8
Degree of sensitization stereotypy	0.2	0.3	0.5	0.4	-0.1	-0.3	-0.7	-0.6	-0.7
Conditioned locomotion	1.7	2.0	3.7	1.2	-1.8	-1.9	1.5	0.8	0.8
Cocaine response after cond. corrected	0.8	1.3	2.1	0.8	-1.0	-1.5	-0.6	-1.3	-1.3
Cocaine response after cond. not corrected	1.0	1.5	3.0	1.3	-1.2	-1.7	-0.4	-1.1	-1.2
Cocaine response before conditioning	0.1	0.1	0.2	0.1	0.4	0.4	0.2	0.3	0.3
Saline control response	0.2	0.3	0.7	-0.1	-0.1	0.3	0.6	0.8	0.8
Bone: connectivity density	1.2	1.9	4.6	2.1	-1.7	-1.9	0.6	0.2	0.1
Bone: cortical apparent density	3.2	5.1	9.1	-3.0	2.5	2.6	-2.1	-1.5	-1.3
Bone: cortical area	0.1	0.2	0.4	0.6	-0.6	-0.7	0.3	0.3	0.3
Bone: cortical porosity	3.2	3.5	6.4	2.5	-1.9	-1.8	1.8	1.5	1.4
Bone: cortical porosity	5.6	6.2	10.0	3.2	-2.6	-2.6	2.5	2.0	1.9
Bone: cortical thickness	0.5	0.8	1.9	-1.4	1.0	1.1	-0.7	-0.4	-0.3
Bone: cortical thickness	2.9	3.5	5.0	-1.9	1.7	1.2	-2.2	-2.1	-2.0
Bone: cortical tissue density	3.2	5.0	9.1	-3.0	2.5	2.6	-2.1	-1.5	-1.3
Condit. Reinf. active minus inactive responses	0.3	0.4	0.8	-0.1	-0.1	-0.6	-0.4	-0.9	-0.9
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.1	-0.2	0.5	0.2	-0.7	-0.9	-1.1
Condit. Reinf. active responses	0.4	0.6	1.7	0.3	-0.8	-1.3	-0.1	-0.8	-0.7
Condit. Reinf. inactive responses	0.2	0.3	1.1	0.1	-0.8	-1.1	0.2	-0.2	-0.1
Incentive salience index mean	0.6	0.8	1.8	-0.2	-0.1	-0.8	-0.7	-1.3	-1.3
Condit. Reinf. lever presses	0.2	0.3	0.7	0.1	-0.3	-0.8	-0.1	-0.6	-0.6
Condit. Reinf. active minus inactive responses	1.3	2.0	6.2	1.1	-1.9	-2.5	0.1	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.5	0.9	1.5	0.1	-0.7	-1.2	-0.6	-1.2	-1.2
Condit. Reinf. active responses	1.0	1.4	4.1	0.6	-1.4	-2.0	-0.4	-1.1	-0.9
Condit. Reinf. inactive responses	0.1	0.2	0.3	0.2	-0.2	-0.4	-0.5	-0.5	-0.4
Condit. Reinf. lever presses	1.7	2.5	4.7	-1.3	0.8	0.2	-2.0	-2.2	-2.1
Condit. Reinf. lever reinforcers received	1.1	1.5	3.4	0.4	-1.2	-1.8	-0.7	-1.4	-1.2
Conditioned reinforcement - actives	0.1	0.4	0.9	0.1	-0.4	-0.1	0.8	0.9	0.9
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.2	0.1	0.1	-0.1	0.2	0.1
Conditioned locomotion	0.1	0.1	0.3	-0.6	-0.3	-0.2	0.2	0.1	0.3
Patch foraging indifference point 0 sec	1.3	3.7	5.9	-1.4	1.7	0.9	-2.2	-2.4	-2.4
Patch foraging indifference point AUC	0.0	0.0	0.2	0.4	-0.1	-0.4	0.1	0.0	-0.0
Delay disc. indifference point, 0s delay	2.3	2.6	3.4	-1.8	1.7	1.7	-1.6	-1.3	-1.3
Delay disc. indifference point, 16s delay	0.2	0.3	0.5	-0.3	0.4	0.3	-0.7	-0.6	-0.7
Delay disc. indifference point, 2s delay	2.1	2.4	3.5	-1.7	1.0	0.6	-1.8	-1.9	-1.7
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	-0.5	0.5	0.7	-0.2	0.1	0.1
Delay disc. indifference point, 4s delay	1.3	1.3	1.8	-1.2	1.2	1.2	-1.3	-1.0	-0.9
Delay disc. indifference point, 8s delay	0.0	0.0	0.2	0.4	-0.0	-0.1	-0.0	-0.0	-0.1
Indifference point function ln k	0.8	2.5	3.4	-1.7	1.3	1.1	-1.6	-1.8	-1.8
Indifference point function log k	0.8	2.5	3.4	-1.7	1.3	1.1	-1.6	-1.8	-1.8
Patch foraging total patch changes 0 sec	1.2	3.5	5.6	-1.5	1.6	0.9	-2.2	-2.4	-2.3
Patch foraging total patch changes 12 sec	0.6	0.8	1.7	-0.7	0.5	-0.1	-0.9	-1.3	-1.2
Patch foraging total patch changes 18 sec	1.5	3.6	5.8	-1.6	2.4	1.8	-1.9	-1.7	-1.8
Patch foraging total patch changes 24 sec	0.0	0.0	0.1	0.2	0.2	-0.1	-0.1	-0.1	-0.1
Patch foraging total patch changes 6 sec	1.1	1.9	3.3	-0.8	1.4	0.7	-1.8	-1.6	-1.6
Patch foraging time to switch 0 sec	0.2	0.8	1.9	0.9	-0.3	0.2	0.8	1.4	1.3
Patch foraging water rate 0 sec	0.0	0.1	0.6	-0.0	-0.1	-0.8	-0.1	-0.4	-0.2
Patch foraging water rate 12 sec	0.7	2.7	5.4	-1.3	0.8	0.3	-1.9	-2.3	-2.2
Patch foraging water rate 18 sec	0.1	0.2	0.6	0.2	-0.5	-0.8	-0.1	-0.6	-0.4
Patch foraging water rate 24 sec	0.2	0.3	0.6	0.5	-0.4	-0.3	0.8	0.5	0.6
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.2	-0.2	-0.4	-0.0	-0.2	-0.0
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	2.8	1.3	-1.5	-1.7	0.9	0.5	0.6
Distance traveled before self-admin	0.9	2.0	3.4	1.4	-1.8	-1.8	1.3	0.9	0.9
Distance traveled after self-admin	0.2	0.3	1.1	-1.0	0.2	0.1	-0.5	-0.6	-0.5
Extensor digitorum longus weight	0.9	3.6	8.5	-2.4	2.4	2.9	-1.2	-0.1	0.0
Bone: elastic displacement	0.4	0.5	1.0	-0.9	0.2	0.1	-0.6	-1.0	-0.9
Bone: elastic work	0.8	1.1	2.5	1.0	-1.5	-1.6	0.9	0.2	0.2
Bone: endosteal estimation	2.4	5.9	11.0	3.3	-2.8	-3.2	2.0	1.1	0.9
Bone: endosteal perimeter	1.8	4.5	9.0	3.0	-2.4	-2.8	1.6	1.1	0.9
Epididymis fat weight	0.8	4.2	6.7	1.5	-2.0	-1.5	2.6	2.3	2.2
Delta time in closed arm before/after self-admin	0.2	0.2	0.3	-0.4	0.6	0.5	-0.4	-0.1	-0.2
Delta time in open arm before/after self-admin	2.2	2.6	5.5	2.3	-2.0	-2.3	1.0	0.4	0.3
Diff in mean of infusions in LGA sessions	0.3	0.6	1.3	-0.2	0.3	-0.2	-0.9	-1.1	-1.1
Delay discount exponential model param	0.5	0.6	1.0	0.7	-0.7	-0.6	1.0	0.9	0.8
Extinction: sum of active levers before priming	0.6	0.8	1.3	0.7	-1.1	-1.0	1.0	0.7	0.8
Active lever presses in extinction session 6	0.7	0.7	2.4	0.4	-1.2	-1.6	0.4	-0.3	-0.2
Bone: final force	3.5	5.7	6.9	2.2	-2.4	-2.3	2.6	2.3	2.3
Bone: final moment	3.2	5.1	6.4	2.0	-2.2	-2.1	2.5	2.3	2.3
Food consumed during 24 hour testing period	0.2	0.4	0.7	0.4	-0.6	-0.5	0.8	0.7	0.8
Glucose	0.7	1.1	2.6	-0.4	-0.4	0.3	1.3	1.5	1.6
Heart weight	0.1	0.1	0.2	0.3	-0.3	-0.4	-0.3	-0.3	-0.3
Delay discount hyperbolic model param	0.5	0.7	1.1	0.8	-0.7	-0.6	1.0	0.9	0.9
Intermittent access intake day 1-15 change	0.0	0.2	0.6	-0.8	0.1	0.4	-0.4	0.2	0.4
Intermittent access intake escalation	0.1	0.3	1.0	-1.0	0.4	0.7	-0.5	0.0	0.3
Intermittent access intake escalation 2	0.1	0.2	0.5	0.2	-0.7	-0.4	0.3	0.5	0.6
Intermitt. access day 1 inactive lever presses	0.1	1.8	4.5	-2.1	1.5	1.9	-0.8	-0.3	-0.1
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.9	-0.7	0.9	1.0	-0.6	-0.2	-0.2
Intermitt. access escalation Index	0.7	2.3	3.6	1.3	-1.3	-0.8	1.6	1.9	1.9
Intermittent access day 1 total infusions	0.3	0.8	1.8	0.5	-1.2	-1.3	1.0	0.4	0.5
Intermittent access day 15 total infusions	0.1	0.2	0.4	-0.6	-0.4	-0.1	0.2	0.3	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.6	-0.8	-0.4	-0.2	0.2	0.2	0.4
Intermittent access total infusions	0.3	0.4	0.8	-0.1	-0.9	-0.7	0.7	0.4	0.6
Intermittent access day 1 locomotion	0.0	0.1	0.2	-0.2	-0.4	-0.4	0.2	-0.1	0.0
Intermittent access day 15 total locomotion	0.0	0.2	0.5	-0.1	-0.6	-0.7	0.1	-0.1	0.1
Intermittent access total locomotion	0.1	0.1	0.2	-0.5	-0.4	-0.3	0.3	0.0	0.2
Intermittent access standard deviation	0.0	0.1	0.6	-0.7	-0.1	-0.1	0.1	-0.2	0.0
Left kidney weight	0.0	0.2	0.4	0.5	-0.6	-0.5	0.3	-0.0	-0.1
Right kidney weight	0.0	0.2	0.6	0.8	-0.4	-0.5	0.2	-0.2	-0.3
Cocaine induced anxiety	0.1	0.2	0.5	0.3	0.7	0.6	-0.4	0.1	-0.0
Post-drug Anxiety	0.1	0.1	0.3	0.3	0.5	0.4	-0.6	0.1	0.1
Baseline Anxiety	0.1	0.1	0.2	0.5	-0.3	-0.4	0.1	0.1	0.1
Tail length	6.4	34.7	51.4	7.2	-6.4	-6.1	6.1	4.7	4.3
Length with tail	10.5	46.6	63.3	8.0	-7.6	-7.3	7.1	5.4	5.1
Length without tail	2.3	12.2	19.1	3.8	-4.3	-4.4	3.4	2.2	2.1
Times rat made contact with spout	0.4	0.4	0.9	0.4	-0.3	-0.0	1.0	0.9	0.8
Lifetime Intake	0.2	0.2	0.3	-0.4	-0.6	-0.3	0.6	0.4	0.6
Liver weight, left	5.6	9.6	11.8	3.4	-3.1	-2.7	3.2	3.1	3.0
Liver weight, right	1.0	1.7	2.5	1.6	-1.5	-1.3	1.4	1.0	1.0
Locomotor activity	0.2	0.3	0.6	0.4	-0.8	-0.8	0.1	0.2	0.4
Locomotor testing distance	0.1	0.3	0.6	0.1	-0.6	-0.8	-0.4	-0.5	-0.4
Locomotor testing rearing	0.1	0.4	0.8	0.7	-0.9	-0.8	0.3	0.4	0.5
Locomotion in novel chamber	1.2	1.7	2.8	-1.7	1.2	1.0	-1.3	-1.3	-1.2
Locomotion in novel chamber post-restriction	0.2	0.5	1.3	-1.0	0.9	1.1	-0.4	-0.1	-0.1
Fecal boli incidents, locomotor time 1	0.4	1.0	2.1	1.4	-0.8	-1.4	-0.4	-0.7	-0.8
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	-0.7	0.0	0.4	-0.1	0.0	0.2
Time >=10cm from walls, locomotor time 1	2.6	3.3	6.2	-0.5	1.2	0.4	-2.4	-2.4	-2.5
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.1	0.0	-0.1	-0.5	-0.7	-0.7
Total resting periods, locomotor time 1	0.9	1.0	1.6	-0.6	0.8	0.6	-1.2	-1.2	-1.3
Rest time, locomotor task time 1	0.0	0.0	0.0	0.1	-0.1	-0.0	0.2	0.2	0.2
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.2	-0.1	-0.3	-0.5	-0.6	-0.6
Vertical activity count, locomotor time 1	0.0	0.1	0.2	-0.1	0.4	0.5	0.0	0.4	0.4
Time >=10cm from walls, locomotor time 2	0.5	1.4	3.2	0.2	-0.1	-0.8	-1.3	-1.7	-1.8
Bouts of movement, locomotor time 2	0.7	2.4	3.9	-1.3	1.2	0.9	-2.0	-1.9	-1.7
Total resting periods, locomotor time 2	0.6	2.4	3.8	-1.3	1.2	0.9	-2.0	-1.9	-1.8
Rest time, locomotor task time 2	0.1	0.1	0.3	0.1	0.3	0.4	0.3	0.6	0.5
Distance moved, locomotor task time 2	0.4	0.5	1.1	-0.0	0.1	-0.1	-0.8	-1.0	-1.1
Vertical activity count, locomotor time 2	0.2	0.4	0.7	-0.8	0.6	0.5	-0.7	-0.6	-0.6
Light reinforcement 1	0.1	0.6	3.0	-1.7	0.2	0.7	0.1	0.2	0.4
Light reinforcement 2	0.2	0.4	0.9	-0.5	-0.9	-0.9	0.2	-0.5	-0.4
Bone: marrow area	2.2	5.4	10.1	3.2	-2.7	-3.1	1.9	1.1	0.9
Bone: maximum diameter	0.3	0.5	1.3	1.1	-0.8	-1.1	0.1	0.0	-0.0
Bone: maximum force	3.7	7.3	8.6	2.9	-2.9	-2.9	2.8	2.3	2.2
Bone: maximum moment	3.3	6.2	7.1	2.6	-2.6	-2.6	2.7	2.2	2.2
Mean time between licks in bursts	0.1	0.3	0.6	-0.5	0.2	0.6	0.5	0.7	0.8
Mean num. licks in bursts	0.2	0.6	1.1	0.9	-0.5	-0.3	0.9	1.0	1.0
Cd content in liver	0.7	0.8	1.2	0.7	-1.1	-1.1	0.9	0.8	0.8
Co content in liver	0.1	0.1	0.2	0.1	0.2	0.3	0.1	0.4	0.4
Cu content in liver	0.1	0.2	0.4	0.3	-0.5	-0.6	0.5	-0.0	-0.0
Fe content in liver	1.2	1.5	2.8	1.4	-1.5	-1.7	1.0	0.7	0.7
K content in liver	0.2	0.2	0.4	-0.1	0.6	0.4	-0.4	-0.5	-0.6
Mg content in liver	0.1	0.1	0.2	0.3	0.1	-0.0	-0.2	-0.4	-0.5
Mn content in liver	1.6	1.8	3.0	-1.7	1.7	1.7	-1.0	-0.8	-0.8
Na content in liver	0.3	0.3	0.5	0.7	-0.6	-0.7	-0.3	-0.5	-0.4
Rb content in liver	0.8	0.9	2.1	-0.0	0.3	-0.2	-1.4	-1.3	-1.2
Se content in liver	0.1	0.1	0.3	-0.2	-0.5	-0.6	0.0	-0.2	-0.0
Sr content in liver	3.4	3.0	5.0	1.2	-1.5	-1.0	2.2	2.0	2.0
Zn content in liver	0.5	0.6	1.2	0.8	-0.6	-0.6	1.1	0.8	0.8
Bone: minimum diameter	0.5	0.9	1.8	1.2	-1.0	-1.3	0.8	0.5	0.4
Time in familiar zone, hab. session 1	0.2	0.2	0.4	0.3	0.1	0.5	0.2	0.7	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.5	-0.3	-0.1	-0.4	-0.3	-0.7	-0.6
Total zone transitions, hab. session 1	0.8	1.1	2.0	-0.2	0.9	0.6	-1.4	-1.2	-1.3
Total locomotion distance, hab. session 1	0.4	0.5	1.3	0.1	-0.1	-0.5	-0.7	-1.1	-1.1
Locomotion velocity, hab. session 1	0.2	0.3	0.8	0.7	-0.7	-0.9	0.2	-0.2	-0.2
Time in familiar zone, hab. session 2	0.8	0.9	1.6	-1.3	1.0	1.1	-0.6	-0.7	-0.8
Time in novel zone, hab. session 2	0.6	0.7	0.9	0.9	-0.9	-1.0	0.5	0.7	0.8
Total zone transitions, hab. session 2	0.3	0.4	0.7	0.7	-0.2	0.0	0.6	0.9	0.8
Total locomotion distance, hab. session 2	1.1	1.4	2.1	1.2	-1.1	-0.8	1.4	1.3	1.2
Locomotion velocity, hab. session 2	1.3	1.8	2.5	1.5	-1.1	-0.8	1.6	1.5	1.4
Novel to familiar place preference ratio	1.6	2.0	3.3	1.4	-1.8	-1.8	1.6	0.8	0.8
Novelty place preference	1.6	2.1	3.2	1.5	-1.8	-1.8	1.5	0.9	0.9
Time in novel zone, NPP test	1.3	1.6	2.7	1.3	-1.6	-1.6	1.4	0.7	0.7
Total zone transitions, NPP test	0.1	0.1	0.2	-0.3	0.3	0.4	-0.3	-0.1	-0.1
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.5	0.0	-0.0	-0.0	-0.4	-0.3
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.4	0.0	0.0	0.1	-0.2	-0.1
Intraocular pressure	1.6	2.7	5.0	-2.0	2.0	2.2	-1.3	-0.9	-0.9
Delta distance traveled before/after self-admin	1.0	1.1	2.1	-1.5	1.1	1.1	-1.0	-0.8	-0.7
Delta ambulatory time before/after self-admin	0.3	0.6	1.8	-1.3	0.6	0.6	-0.6	-0.6	-0.4
Parametrial fat weight	0.2	0.5	0.9	-0.2	0.2	0.4	0.9	0.9	0.9
Pavlov. Cond. lever latency	0.5	0.6	1.7	-0.3	0.8	1.3	0.2	0.8	0.7
Pavlov. Cond. magazine entry latency	0.6	0.7	1.8	-0.1	-0.1	-0.4	-0.7	-1.3	-1.3
Pavlov. Cond. change in total contacts	1.6	1.7	4.0	-0.7	0.5	-0.3	-1.3	-2.0	-2.0
Pavlov. Cond. index score	0.4	0.5	0.9	0.0	-0.6	-1.0	-0.2	-0.9	-0.8
Pavlov. Cond. latency score	0.5	0.7	1.6	0.3	-0.8	-1.3	-0.2	-0.9	-0.8
Pavlov. Cond. lever contacts	0.4	0.5	0.9	-0.0	-0.5	-1.0	-0.3	-1.0	-0.9
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.1	0.4	0.7	0.2	0.9	0.9
Pavlov. Cond. intertrial magazine entries	1.0	1.2	1.4	1.1	-1.2	-1.1	1.1	1.0	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.3	-0.2	-0.2	-0.6	-0.5	-1.2	-1.1
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.1	-0.2	-0.5	-0.3	-0.9	-0.9
Pavlov. Cond. lever latency	1.8	2.6	4.2	1.2	-1.2	-0.8	1.9	2.0	2.1
Pavlov. Cond. magazine entry latency	0.3	0.5	0.8	-0.3	0.8	0.9	-0.7	-0.5	-0.7
Pavlov. Cond. change in total contacts	1.2	2.8	5.5	-1.0	1.1	0.6	-2.0	-2.3	-2.3
Pavlov. Cond. index score	1.1	1.8	3.1	-0.8	0.9	0.7	-1.6	-1.7	-1.8
Pavlov. Cond. latency score	0.8	1.4	2.5	-0.7	0.8	0.6	-1.4	-1.5	-1.6
Pavlov. Cond. lever contacts	2.1	3.1	5.6	-1.2	1.1	0.7	-2.1	-2.3	-2.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.1	0.1	0.0	0.3	0.5	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.1	0.2	-0.5	-0.0	-0.3	-0.3	-0.3	-0.0
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	3.5	-0.9	1.0	0.7	-1.7	-1.8	-1.9
Pavlov. Cond. response bias	1.0	1.4	3.1	-0.4	0.6	0.3	-1.5	-1.6	-1.8
Time in closed arm before self-admin	1.4	2.4	3.8	1.9	-1.8	-1.9	1.4	0.9	0.9
Time in closed arm after self-admin	0.4	0.5	1.1	0.0	0.0	-0.5	-0.8	-1.1	-1.1
Time in open arm before self-admin	1.7	2.1	5.3	-2.3	1.5	2.1	-0.3	0.3	0.5
Time in open arm after self-admin	0.3	0.3	0.5	0.7	-0.6	-0.7	0.5	0.4	0.3
Bone: periosteal estimation	1.5	3.7	6.8	2.6	-2.2	-2.6	1.5	0.9	0.8
Bone: periosteal perimeter	1.0	2.0	3.9	1.7	-1.7	-2.0	1.1	0.6	0.6
Bone: post-yield work	1.2	2.1	2.4	1.5	-1.5	-1.5	1.5	1.3	1.3
Progressive ratio test 1 active lever presses	0.1	0.1	0.2	-0.4	0.3	0.5	-0.1	0.1	0.1
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	-0.3	0.2	0.3	-0.1	0.0	0.0
Progressive ratio test 1 inactive lever presses	0.4	1.1	2.1	-1.3	0.7	1.4	0.4	0.9	1.0
Progressive ratio test 2 active lever presses	0.1	0.2	0.4	0.1	-0.3	-0.1	0.3	0.6	0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.3	-0.0	-0.3	-0.0	0.3	0.5	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.5	-0.3	-0.3	0.1	0.4	0.6	0.7
Incentive Sensitization - Responses	0.2	0.5	0.8	0.9	-0.7	-0.6	0.6	0.7	0.7
Incentive Sensitization - Breakpoint	0.2	0.5	0.7	0.8	-0.7	-0.6	0.6	0.8	0.8
Sum of active levers in priming session hrs 5-6	1.6	1.5	3.1	1.1	-1.6	-1.7	1.2	0.5	0.6
Progressive ratio	0.3	0.8	2.1	-1.0	1.2	1.4	-0.4	-0.2	-0.3
Food seeking constrained by brief footshock	0.0	0.1	0.1	0.2	0.2	0.3	0.2	0.3	0.2
Seeking ratio, punishment vs. effort	0.5	1.2	2.4	1.6	-1.3	-1.3	0.7	0.6	0.7
Retroperitoneal fat weight	0.7	3.3	5.9	0.8	-1.5	-1.0	2.2	2.3	2.4
Reaction time number correct	0.2	0.7	1.0	-1.0	0.7	0.7	-0.8	-0.9	-0.8
Reaction time mean minus median	0.6	3.8	6.6	1.4	-2.0	-1.5	2.6	2.1	2.1
Reaction time mean minus median AUC	0.3	1.8	3.6	0.9	-1.5	-1.1	1.9	1.3	1.2
Reaction time num false alarms	1.4	2.4	4.9	-2.0	2.0	2.2	-0.8	-0.5	-0.6
Reaction time num false alarms AUC	1.1	2.6	5.8	-2.0	2.2	2.4	-0.7	-0.4	-0.5
Reaction time trials correct on left	0.2	0.7	1.0	-1.0	0.7	0.7	-0.8	-0.9	-0.8
Reaction time trials on left	0.2	0.5	0.9	-0.9	0.6	0.7	-0.7	-0.8	-0.7
Reaction time mean	2.5	5.5	7.4	2.1	-2.6	-2.1	2.7	2.2	2.2
Reaction time mean AUC	2.2	5.3	7.6	1.8	-2.6	-2.0	2.8	2.3	2.3
Median of all reaction times	2.8	4.3	5.7	2.0	-2.4	-2.0	2.3	1.9	1.8
Reaction time omissions	1.7	2.7	4.2	1.0	-1.9	-1.3	2.0	1.7	1.8
Reaction time false alarm rate	0.8	1.1	2.8	-1.3	1.5	1.7	-0.3	-0.0	-0.1
Reaction time premature initiation rate	3.5	5.5	8.2	-2.3	2.0	1.3	-2.5	-2.9	-2.7
Reaction time premature initiations	2.1	6.3	8.9	-2.6	2.2	1.6	-2.7	-3.0	-2.8
Std. dev. reaction times	1.4	4.5	6.4	1.8	-2.4	-2.0	2.5	1.9	1.9
Reaction time trials completed	0.2	0.5	0.9	-0.9	0.6	0.7	-0.7	-0.8	-0.7
Reaction time trials AUC	0.2	0.5	0.9	-0.9	0.7	0.7	-0.7	-0.7	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.4	0.5	0.2	0.5	0.2	0.6	0.4
Run reversals in cocaine runway, males	0.9	1.0	2.0	-0.7	0.5	0.2	-1.1	-1.4	-1.4
Latency to leave start box in cocaine runway	3.1	4.2	7.4	-2.4	2.4	2.7	-1.8	-1.2	-1.2
Latency to leave start box in cocaine runway, F	2.5	3.1	6.9	-2.1	2.2	2.6	-1.4	-0.7	-0.7
Latency to leave start box in cocaine runway, M	2.3	2.2	2.7	-1.4	1.6	1.5	-1.6	-1.3	-1.3
Std. dev. time between licks in bursts	0.8	1.4	4.0	-2.0	1.3	1.6	-0.6	-0.4	-0.3
Total sessions with >9 infusions	0.3	0.4	1.2	-1.1	0.4	0.8	0.0	0.1	0.2
Short access day 1 total inactive lever presses	0.2	0.3	1.3	-1.1	0.0	-0.0	-0.3	-0.6	-0.4
Short access day 10 total inactive lever presses	0.0	0.1	0.5	-0.7	0.2	0.0	-0.0	-0.1	0.0
Short access day 1 total infusions	0.3	0.5	0.9	-0.3	-0.8	-0.1	0.9	0.8	0.9
Short access day 10 total infusions	0.1	0.2	0.6	-0.8	-0.6	-0.3	0.5	-0.1	0.1
Short access total infusions	0.1	0.2	0.9	-1.0	-0.2	0.2	0.2	-0.0	0.2
Short access day 1 locomotion	0.1	0.2	0.5	-0.7	0.2	0.6	0.2	0.3	0.4
Short access day 10 total locomotion	0.4	1.5	2.7	-1.6	0.8	0.6	-1.1	-1.5	-1.3
Short access total locomotion	0.2	0.3	1.0	-1.0	0.5	0.8	0.0	0.1	0.2
One hour access (0.3 mA shock)	0.4	0.5	1.2	-0.1	-1.1	-0.9	0.8	0.3	0.5
Compulsive drug intake	0.2	0.2	0.9	-0.3	0.6	0.9	-0.0	0.3	0.2
One hour access (shock baseline)	0.2	0.5	1.6	-0.1	-1.1	-1.3	0.3	-0.2	0.1
Social response proportion	2.8	3.6	7.2	2.0	-2.7	-2.6	1.3	0.9	1.0
Social responses	2.2	2.9	4.8	1.3	-2.2	-1.9	1.5	1.5	1.8
Social time	1.0	1.6	2.6	0.8	-1.6	-1.2	1.2	1.3	1.5
Soleus weight	0.0	0.1	0.2	0.3	-0.4	-0.5	-0.0	-0.3	-0.3
Bone: stiffness	4.6	8.3	9.8	3.1	-2.9	-2.6	3.1	2.8	2.8
Tibialis anterior weight	0.2	0.7	1.6	-0.9	1.1	1.2	-0.7	-0.1	-0.1
Time to tail flick, vehicle, before self-admin	0.6	0.7	1.2	0.7	-0.7	-0.3	1.1	1.1	1.0
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.4	0.6	-0.2	-0.2	0.4	0.4	0.3
Time to tail flick, test, before self-admin	0.8	0.9	1.5	-1.2	1.0	0.9	-0.8	-0.8	-0.8
Time to tail flick, test, after self-admin	0.2	0.2	0.5	-0.4	0.5	0.7	0.0	0.4	0.4
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.3	0.5	0.4	-0.4	-0.3	-0.4
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.1	0.1	0.2	0.0	0.3	0.2
Tibia length	5.3	14.7	22.4	4.7	-3.9	-3.6	4.1	3.4	3.1
Ambulatory time before self-admin	0.6	1.8	2.7	1.2	-1.7	-1.6	1.4	1.0	1.1
Ambulatory time after self-admin	0.3	0.4	1.7	-1.3	0.2	0.1	-0.4	-0.6	-0.4
Bone: tissue strength	3.8	4.0	6.0	1.6	-1.6	-1.1	2.4	2.4	2.4
Total heroin consumption	0.2	0.2	0.5	0.2	-0.7	-0.7	0.5	0.2	0.3
Bone: trabecular number	1.8	3.4	7.2	2.7	-2.3	-2.2	1.2	0.9	0.7
Bone: trabecular spacing	0.6	0.8	1.3	-0.9	1.2	1.0	-0.8	-0.7	-0.7
Bone: trabecular thickness	0.7	0.9	2.2	1.4	-1.2	-1.5	0.3	0.0	-0.1
Bone: trabecular tissue density	0.3	0.5	1.0	0.0	-0.2	-0.1	0.8	1.0	1.0
Water consumed over 24 hours	0.1	0.1	0.5	-0.4	0.4	0.7	0.1	-0.1	-0.1
Number of responses in last shaping day	0.3	0.4	0.9	0.1	0.2	0.8	0.5	1.0	0.9