C7h22orf23

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	C7h22orf23	0.03	0.02	2.7e-03	0.02	0.02	0.02	0.02	1.5e-03	1.8e-03	3.4e-03	5.0e-03
2	NAcc	intron excision ratio	chr7_112586431_112591022	0.04	0.03	9.5e-05	0.01	0.03	0.03	0.03	3.7e-03	1.7e-05	4.6e-05	9.2e-05
3	PL	intron excision ratio	chr7_112586431_112591022	0.09	0.04	1.1e-09	0.1	0.1	0.09	0.09	1.6e-10	1.4e-10	7.6e-10	3.0e-10
4	pVTA	intron excision ratio	chr7_112586431_112591022	0.04	0.02	4.3e-03	0.02	0.03	0.01	0.02	4.8e-03	1.6e-03	8.1e-02	6.3e-03
5	NAcc	gene expression	C7h22orf23	0.03	0.02	7.5e-04	0.02	0.02	0.02	0.02	1.4e-03	1.3e-03	8.5e-04	9.6e-04
6	IC	intron excision ratio	chr7_112586431_112591022	0.31	0.13	1.2e-07	0.18	0.16	0.15	0.16	3.1e-08	2.8e-07	6.3e-07	2.6e-07
7	Brain	intron excision ratio	chr7_112586431_112591022	0.08	0.04	1.5e-06	0.09	0.07	0.05	0.08	2.4e-08	3.7e-07	1.0e-05	1.4e-07
8	PL	mRNA stability	C7h22orf23	0.04	0.02	6.8e-04	0.04	0.03	0.03	0.03	5.8e-05	8.3e-04	3.7e-04	8.4e-04
9	BLA	intron excision ratio	chr7_112586431_112591022	0.08	0.05	5.3e-03	0.05	0.04	0.04	0.04	8.2e-04	3.0e-03	4.9e-03	2.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.0	0.0	0.1	0.1	0.3	-0.4	0.0	0.4	0.2	0.0	-0.0	0.0
Area under the delay curve	1.1	1.7	3.4	1.7	1.8	1.3	0.7	1.2	-1.2	-1.2	-1.2	-1.2
BMI with tail	0.2	0.6	1.8	-0.8	-0.3	-1.3	0.3	1.0	0.7	0.8	0.8	0.7
BMI without tail	0.4	2.4	4.4	-0.9	-1.6	-2.1	-1.1	-0.6	1.7	1.7	1.7	1.7
Body weight	0.7	3.2	7.6	-2.8	-1.8	-2.4	-0.5	-0.4	1.7	1.8	1.8	1.7
Weight adjusted by age	0.1	0.4	2.1	-1.4	-0.6	-0.2	0.0	-0.3	0.0	0.6	0.6	0.6
Bone surface	0.2	0.4	0.9	0.2	0.3	0.8	0.4	0.0	-0.5	-0.9	-0.9	-0.9
Bone volume	0.0	0.0	0.1	0.4	-0.0	0.0	-0.1	-0.1	0.1	-0.3	-0.3	-0.3
Breakpoint value in progressive ratio session	0.2	0.3	0.5	0.7	0.7	0.2	0.3	0.6	-0.2	-0.6	-0.6	-0.5
Number of licking bursts	0.2	0.7	1.6	1.3	-0.7	-0.4	-1.0	-1.0	0.7	0.8	0.8	0.7
Context. condit. distance diff. score	0.8	1.0	5.5	-2.4	-1.3	-0.7	-0.0	-0.2	0.4	0.7	0.7	0.6
Locomotion velocity, session 1	0.5	0.6	1.5	-0.9	0.2	1.2	0.7	-0.3	-0.9	-0.8	-0.8	-0.7
Locomotion distance, session 1	1.6	2.0	4.3	1.8	1.0	2.1	0.4	-0.0	-1.5	-1.6	-1.6	-1.5
Locomotion velocity, session 2	2.9	3.4	5.1	-0.0	1.6	2.0	2.0	1.4	-1.9	-2.3	-2.3	-2.1
Locomotion distance, session 2	2.0	2.8	4.7	2.0	1.7	2.2	0.7	0.4	-1.7	-1.9	-1.9	-1.7
Locomotion velocity, session 3	0.6	0.7	2.0	-1.3	-1.4	0.5	-0.3	-1.0	-0.3	0.6	0.6	0.5
Locomotion distance, session 3	1.0	1.2	2.1	1.2	-1.4	-0.0	-1.4	-1.4	0.5	0.9	0.9	0.9
Stereotopy head waving bouts, day 3	0.2	0.2	1.1	-1.1	0.2	-0.0	0.6	0.2	-0.1	-0.0	-0.0	-0.3
Stereotopy head waving duration, day 3	0.7	0.9	5.9	-2.4	0.3	0.0	1.3	0.6	-0.3	-0.1	-0.1	-0.2
Locomotion velocity, session 7	0.6	0.7	1.1	-1.0	-0.9	-0.8	-0.5	-0.6	0.9	0.8	0.8	0.8
Locomotion distance, session 7	1.0	1.3	1.8	-1.1	-0.9	-1.0	-1.1	-1.2	1.2	1.2	1.2	1.4
Stereotopy head waving bouts, day 7	0.9	1.0	4.3	-2.1	-0.1	0.7	1.4	0.8	-0.7	-0.7	-0.7	-0.8
Stereotopy head waving duration, day 7	1.2	1.5	3.3	-1.8	0.4	0.9	1.8	1.4	-1.1	-0.9	-0.9	-1.0
Locomotion velocity, session 8	1.0	1.2	3.5	-1.9	0.3	1.3	1.3	0.4	-1.2	-0.8	-0.8	-0.8
Locomotion distance, session 8	0.4	0.6	1.4	-1.2	0.3	0.8	0.8	0.6	-0.9	-0.7	-0.7	-0.7
Degree of sensitization distance	1.0	1.1	7.0	-2.7	0.3	-1.1	0.4	0.3	0.7	0.4	0.4	0.5
Degree of sensitization stereotypy	1.6	1.8	3.2	-1.8	0.3	1.4	1.8	1.1	-1.4	-1.2	-1.2	-1.2
Conditioned locomotion	0.5	0.6	1.5	-1.2	-0.7	-0.7	-0.1	-0.5	0.7	0.9	0.8	0.8
Cocaine response after cond. corrected	0.6	0.8	1.5	-0.9	1.0	0.8	1.2	0.8	-0.8	-0.9	-0.9	-0.9
Cocaine response after cond. not corrected	0.7	1.0	1.7	-0.4	1.1	0.8	1.3	1.1	-0.9	-1.1	-1.1	-1.1
Cocaine response before conditioning	0.2	0.2	1.9	1.4	-0.2	-0.2	-0.4	0.1	0.1	-0.1	-0.1	-0.1
Saline control response	0.1	0.2	0.6	-0.6	-0.8	0.1	-0.2	-0.6	-0.1	-0.3	-0.3	-0.3
Bone: connectivity density	0.1	0.1	0.4	-0.6	-0.4	-0.4	-0.3	-0.4	0.5	0.2	0.2	0.1
Bone: cortical apparent density	1.8	2.9	4.9	0.5	-2.2	-1.7	-2.0	-1.9	1.9	1.6	1.6	1.5
Bone: cortical area	0.1	0.1	0.4	-0.1	0.4	0.0	0.6	0.2	0.1	-0.4	-0.4	-0.4
Bone: cortical porosity	1.2	1.3	2.1	-0.5	1.3	0.9	1.4	1.1	-1.1	-1.2	-1.2	-1.2
Bone: cortical porosity	1.9	2.1	3.5	-1.1	1.4	1.4	1.9	1.2	-1.5	-1.5	-1.5	-1.5
Bone: cortical thickness	0.2	0.4	3.1	1.8	0.3	-0.1	-0.3	-0.1	0.3	0.1	0.1	-0.0
Bone: cortical thickness	0.4	0.5	3.8	2.0	0.7	0.3	-0.0	0.1	-0.1	-0.2	-0.2	-0.3
Bone: cortical tissue density	1.8	2.8	4.8	0.3	-2.2	-1.6	-2.0	-1.9	1.9	1.5	1.5	1.4
Condit. Reinf. active minus inactive responses	1.1	1.3	2.3	0.7	-1.3	-0.9	-1.5	-1.5	1.1	0.9	0.9	1.0
Condit. Reinf. active-inactive response ratio	0.9	1.0	2.3	0.1	-1.5	-0.7	-1.3	-1.5	0.9	0.7	0.7	0.8
Condit. Reinf. active responses	2.1	2.6	4.3	1.0	-1.5	-1.6	-2.1	-1.6	1.6	1.7	1.7	1.7
Condit. Reinf. inactive responses	1.9	2.4	3.9	0.8	-1.0	-1.7	-1.8	-0.8	1.4	2.0	2.0	1.9
Incentive salience index mean	2.3	2.9	4.3	0.7	-1.7	-1.7	-2.1	-1.9	1.9	1.6	1.6	1.7
Condit. Reinf. lever presses	3.0	4.5	6.0	0.8	-1.9	-2.4	-2.3	-1.9	2.5	2.2	2.3	2.3
Condit. Reinf. active minus inactive responses	0.6	0.9	1.4	0.3	1.2	1.0	0.7	0.6	-1.0	-1.1	-1.1	-1.1
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.8	-0.3	0.9	0.6	0.7	0.5	-0.7	-0.8	-0.8	-0.7
Condit. Reinf. active responses	1.5	2.1	2.9	0.1	1.5	1.7	1.2	1.0	-1.7	-1.7	-1.7	-1.6
Condit. Reinf. inactive responses	0.5	0.7	1.6	0.5	0.5	1.3	0.5	0.1	-1.0	-1.0	-1.0	-0.9
Condit. Reinf. lever presses	0.1	0.1	0.5	0.7	0.6	0.1	-0.1	0.4	-0.2	-0.4	-0.3	-0.3
Condit. Reinf. lever reinforcers received	1.2	1.7	2.2	-0.1	1.4	1.4	1.2	1.0	-1.5	-1.5	-1.5	-1.4
Conditioned reinforcement - actives	0.3	1.1	3.2	1.8	1.0	1.5	0.2	0.3	-1.0	-0.8	-0.8	-0.8
Conditioned reinforcement - inactives	0.3	0.7	5.2	2.3	0.6	0.0	-0.8	-0.3	0.2	0.2	0.2	0.2
Conditioned locomotion	1.6	2.4	4.3	1.1	2.1	1.8	1.5	1.4	-1.9	-1.3	-1.3	-1.3
Patch foraging indifference point 0 sec	0.6	1.7	2.5	-0.5	-1.4	-1.2	-1.4	-1.6	1.3	1.4	1.4	1.4
Patch foraging indifference point AUC	0.3	0.7	2.3	1.1	-0.5	0.4	-1.2	-1.5	0.0	0.6	0.6	0.6
Delay disc. indifference point, 0s delay	0.5	0.6	1.7	0.6	1.3	0.0	0.9	1.3	-0.5	-0.4	-0.5	-0.5
Delay disc. indifference point, 16s delay	1.1	1.6	3.0	1.5	1.7	1.4	0.7	1.1	-1.1	-1.2	-1.2	-1.2
Delay disc. indifference point, 2s delay	7.8	8.7	12.9	2.9	3.6	2.8	2.3	3.2	-2.8	-3.0	-2.9	-2.8
Delay disc. indifference point, 24s delay	0.6	1.0	3.7	-0.6	-1.3	-0.1	-1.1	-1.9	0.8	0.8	0.6	0.8
Delay disc. indifference point, 4s delay	2.3	2.4	4.4	0.9	2.1	1.5	1.3	1.8	-1.5	-1.4	-1.6	-1.5
Delay disc. indifference point, 8s delay	0.2	0.3	2.1	1.4	0.3	-0.1	-0.8	-0.3	0.2	0.1	0.3	0.2
Indifference point function ln k	0.2	0.5	2.5	-1.6	-0.2	-0.3	0.8	0.7	0.1	-0.4	-0.4	-0.4
Indifference point function log k	0.2	0.5	2.5	-1.6	-0.2	-0.3	0.8	0.7	0.1	-0.4	-0.4	-0.4
Patch foraging total patch changes 0 sec	0.5	1.4	2.0	-0.0	-1.2	-1.1	-1.4	-1.4	1.1	1.2	1.2	1.2
Patch foraging total patch changes 12 sec	0.2	0.2	1.3	0.0	-0.4	0.4	-0.4	-1.1	0.0	0.0	0.0	0.0
Patch foraging total patch changes 18 sec	0.4	0.9	2.5	0.4	-0.7	-0.4	-1.1	-1.6	0.8	1.0	1.0	1.0
Patch foraging total patch changes 24 sec	0.7	2.3	3.8	1.3	-1.3	-1.0	-1.9	-1.9	1.2	1.5	1.6	1.5
Patch foraging total patch changes 6 sec	0.4	0.7	1.3	0.5	-0.6	-0.3	-1.0	-1.2	0.5	1.0	1.0	1.0
Patch foraging time to switch 0 sec	0.9	3.3	7.2	-0.3	2.4	1.2	2.3	2.7	-1.5	-1.6	-1.6	-1.6
Patch foraging water rate 0 sec	1.6	6.1	8.3	-0.7	-2.8	-2.4	-2.6	-2.9	2.4	2.6	2.6	2.5
Patch foraging water rate 12 sec	0.5	1.8	3.3	0.5	-1.8	-1.6	-1.5	-1.5	1.8	1.0	1.0	1.0
Patch foraging water rate 18 sec	1.9	4.1	7.8	-0.5	-2.6	-1.7	-2.1	-2.8	2.0	1.9	1.9	1.9
Patch foraging water rate 24 sec	1.2	1.7	3.5	-1.6	-1.9	-1.3	-0.9	-1.4	1.4	1.0	1.0	1.0
Patch foraging water rate 6 sec	3.6	5.3	7.2	0.5	-2.7	-2.4	-2.5	-2.4	2.5	2.3	2.3	2.2
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.7	0.2	0.5	0.5	0.4	0.8	-0.6	-0.1	-0.1	-0.1
Distance traveled before self-admin	0.9	2.0	4.6	0.7	2.1	1.2	1.4	1.8	-1.3	-1.2	-1.2	-1.2
Distance traveled after self-admin	0.3	0.6	1.2	-0.6	-0.5	-0.6	-0.6	-1.1	0.8	0.8	0.8	0.9
Extensor digitorum longus weight	0.5	1.8	5.2	1.8	1.9	0.3	1.0	2.3	-0.8	-0.9	-0.9	-0.8
Bone: elastic displacement	0.2	0.3	1.7	-1.3	-0.0	-0.2	0.5	0.3	0.0	0.6	0.5	0.5
Bone: elastic work	0.9	1.2	3.7	-1.9	1.1	0.5	1.7	1.3	-0.8	-0.3	-0.3	-0.3
Bone: endosteal estimation	0.5	1.2	3.8	-1.9	0.5	0.8	1.4	0.4	-0.8	-1.1	-1.1	-0.9
Bone: endosteal perimeter	0.5	1.2	3.3	-1.8	0.4	0.7	1.6	0.6	-0.6	-1.2	-1.2	-1.1
Epididymis fat weight	0.1	0.8	5.0	-2.2	-0.8	-0.8	0.3	0.3	0.3	0.2	0.2	0.2
Delta time in closed arm before/after self-admin	0.4	0.4	1.7	1.3	0.6	0.5	0.1	0.3	-0.6	-0.3	-0.3	-0.3
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.5	0.4	0.4	0.4	0.4	-0.4	-0.1	-0.2	-0.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.8	-0.5	-0.8	-0.3	-0.6	-0.9	0.5	0.4	0.5	0.5
Delay discount exponential model param	1.1	1.5	2.9	-1.7	-1.7	-1.3	-0.6	-1.1	1.1	1.1	1.1	1.1
Extinction: sum of active levers before priming	1.6	2.4	3.1	0.7	1.7	1.8	1.4	1.4	-1.4	-1.8	-1.7	-1.7
Active lever presses in extinction session 6	0.5	0.5	0.8	0.1	0.6	0.7	0.7	0.6	-0.5	-0.9	-0.9	-0.9
Bone: final force	0.4	0.6	1.5	-0.5	0.9	0.6	1.2	0.6	-0.5	-0.8	-0.8	-0.9
Bone: final moment	0.4	0.6	1.4	-0.8	0.9	0.5	1.2	0.5	-0.4	-0.8	-0.8	-0.9
Food consumed during 24 hour testing period	0.2	0.5	0.7	0.2	0.6	0.8	0.7	0.3	-0.7	-0.9	-0.9	-0.8
Glucose	0.9	1.5	3.0	0.4	-0.7	-1.7	-1.1	-0.7	1.5	1.4	1.4	1.4
Heart weight	0.7	1.1	7.7	-2.8	-0.9	-0.7	0.4	-0.5	0.8	0.1	0.1	0.2
Delay discount hyperbolic model param	1.9	2.4	4.3	-1.9	-2.1	-1.5	-0.9	-1.5	1.4	1.4	1.5	1.4
Intermittent access intake day 1-15 change	0.0	0.1	0.5	0.7	-0.3	0.0	-0.3	-0.2	0.0	0.2	0.2	0.2
Intermittent access intake escalation	0.0	0.2	0.5	0.7	-0.5	-0.1	-0.5	-0.4	0.2	0.3	0.3	0.3
Intermittent access intake escalation 2	0.3	0.6	0.8	0.5	-0.8	-0.7	-0.9	-0.8	0.7	0.8	0.8	0.8
Intermitt. access day 1 inactive lever presses	0.1	1.0	1.5	-1.2	-0.5	-1.0	-0.7	-1.1	1.1	1.0	1.0	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.4	0.6	-0.1	-0.2	-0.6	-0.7	-0.8	0.7	0.7	0.7	0.7
Intermitt. access escalation Index	0.1	0.3	2.5	1.6	-0.1	0.1	-0.4	0.0	0.0	-0.2	-0.2	-0.2
Intermittent access day 1 total infusions	1.0	2.9	6.0	1.1	1.9	2.4	1.3	1.0	-1.8	-1.7	-1.7	-1.7
Intermittent access day 15 total infusions	0.5	1.3	2.8	1.5	1.1	1.7	0.5	0.5	-1.2	-1.1	-1.1	-1.1
Intermittent access terminal intake (last 3 days)	0.8	1.3	3.3	1.1	1.1	1.8	0.6	0.5	-1.3	-1.2	-1.2	-1.2
Intermittent access total infusions	2.5	2.9	5.6	1.5	2.1	2.4	1.2	1.1	-1.8	-1.6	-1.6	-1.6
Intermittent access day 1 locomotion	0.3	0.6	1.3	1.1	1.1	0.9	0.3	0.4	-0.6	-0.6	-0.6	-0.6
Intermittent access day 15 total locomotion	0.0	0.2	0.6	0.8	0.6	0.5	0.1	-0.1	-0.2	-0.3	-0.3	-0.3
Intermittent access total locomotion	0.1	0.1	0.5	0.7	0.4	-0.0	-0.2	-0.4	0.1	0.2	0.2	0.2
Intermittent access standard deviation	0.0	0.2	1.5	0.1	1.2	0.3	0.6	0.3	-0.3	-0.2	-0.2	-0.2
Left kidney weight	0.7	5.6	29.4	-5.4	0.4	1.3	3.0	1.3	-1.5	-1.4	-1.4	-1.5
Right kidney weight	0.7	4.9	36.1	-6.0	-0.3	0.1	2.4	0.8	-0.6	-0.7	-0.7	-0.7
Cocaine induced anxiety	0.1	0.2	1.0	-0.3	0.5	0.1	0.7	1.0	-0.5	-0.1	-0.1	-0.1
Post-drug Anxiety	0.6	0.7	1.9	-0.7	-0.5	-1.4	-0.2	0.3	0.9	0.9	0.9	0.9
Baseline Anxiety	0.3	0.5	1.3	0.4	-0.7	-0.9	-0.8	-0.8	1.1	0.4	0.4	0.4
Tail length	0.9	4.6	6.2	-0.9	-2.5	-2.4	-2.1	-2.0	2.2	2.3	2.3	2.4
Length with tail	0.8	3.5	6.6	-2.6	-2.4	-1.9	-1.1	-1.6	1.7	1.7	1.7	1.8
Length without tail	0.2	1.2	9.8	-3.1	-0.6	-0.3	0.7	-0.2	0.2	0.2	0.2	0.1
Times rat made contact with spout	4.7	5.4	11.3	1.4	-2.8	-1.8	-3.0	-3.4	2.5	1.8	1.8	1.8
Lifetime Intake	2.6	3.2	5.9	1.5	2.3	2.4	1.3	1.1	-1.9	-1.8	-1.8	-1.8
Liver weight, left	0.1	0.1	0.4	-0.2	-0.3	0.5	0.2	-0.0	-0.6	-0.1	-0.1	-0.1
Liver weight, right	0.7	1.2	4.3	-1.2	-2.1	-0.9	-0.6	-0.9	0.7	0.9	0.9	0.9
Locomotor activity	0.2	0.2	0.9	-0.9	-0.5	-0.0	0.4	-0.1	0.1	-0.5	-0.5	-0.6
Locomotor testing distance	0.2	0.5	0.9	1.0	-0.9	-0.7	-0.9	-0.8	0.9	0.3	0.3	0.2
Locomotor testing rearing	0.1	0.4	1.2	-0.1	-0.2	0.5	0.4	-0.3	-0.2	-1.0	-1.0	-1.1
Locomotion in novel chamber	0.4	0.6	2.8	1.7	-0.5	-0.6	-0.8	0.1	0.4	0.6	0.6	0.6
Locomotion in novel chamber post-restriction	0.3	0.8	5.5	2.4	0.6	0.6	-0.0	0.6	-0.6	-0.4	-0.5	-0.4
Fecal boli incidents, locomotor time 1	0.3	0.8	2.4	-0.1	-0.7	-0.5	-0.9	-1.6	1.0	0.9	0.8	0.8
Change in fecal boli incidents, locomotor task	0.6	0.7	2.6	-0.7	-1.6	-0.3	-0.6	-1.4	0.4	0.4	0.4	0.5
Time >=10cm from walls, locomotor time 1	0.2	0.2	1.5	-1.2	0.2	0.2	0.6	0.3	-0.2	-0.0	-0.1	-0.1
Bouts of movement, locomotor time 1	0.1	0.1	0.4	-0.1	-0.6	-0.2	-0.3	-0.5	0.3	0.2	0.0	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	-0.3	-0.2	-0.3	0.4	0.2	0.1	0.3
Rest time, locomotor task time 1	0.5	0.9	1.1	-1.1	-0.7	-0.9	-0.7	-1.0	0.9	1.1	0.9	1.0
Distance moved, locomotor task time 1	0.1	0.2	0.4	-0.3	-0.1	0.5	0.5	0.4	-0.6	-0.5	-0.4	-0.6
Vertical activity count, locomotor time 1	0.4	2.6	3.9	-0.1	-1.6	-1.9	-1.5	-1.3	1.7	1.9	2.0	1.7
Time >=10cm from walls, locomotor time 2	0.9	2.7	3.8	-1.4	-1.7	-1.6	-1.1	-1.6	1.8	1.7	1.8	2.0
Bouts of movement, locomotor time 2	0.6	2.1	4.6	2.1	1.5	1.0	1.0	1.7	-1.4	-1.4	-1.2	-1.4
Total resting periods, locomotor time 2	0.7	3.0	5.0	2.2	1.9	1.4	1.3	1.9	-1.7	-1.6	-1.5	-1.7
Rest time, locomotor task time 2	0.0	0.0	0.1	0.1	0.3	-0.1	-0.1	-0.2	0.1	0.2	0.1	0.1
Distance moved, locomotor task time 2	0.3	0.4	1.1	-1.0	-0.9	-0.6	-0.3	-0.5	0.5	0.5	0.6	0.6
Vertical activity count, locomotor time 2	1.2	2.8	3.8	-0.6	-1.8	-2.0	-1.4	-1.7	1.9	1.7	1.8	1.9
Light reinforcement 1	0.0	0.2	0.4	-0.1	0.2	0.4	0.4	0.1	-0.3	-0.6	-0.6	-0.6
Light reinforcement 2	0.3	0.7	1.3	-0.1	0.7	0.8	1.1	1.2	-1.2	-0.7	-0.7	-0.7
Bone: marrow area	0.5	1.3	4.1	-2.0	0.5	0.9	1.4	0.4	-0.8	-1.1	-1.1	-1.0
Bone: maximum diameter	0.5	0.9	2.8	-1.7	0.5	0.5	1.5	0.5	-0.5	-0.9	-0.9	-0.9
Bone: maximum force	0.4	0.7	1.7	-0.6	1.0	0.7	1.3	0.6	-0.6	-0.9	-0.9	-0.9
Bone: maximum moment	0.5	0.9	1.8	-0.8	1.0	0.7	1.3	0.6	-0.6	-1.0	-1.0	-1.0
Mean time between licks in bursts	0.5	2.9	4.7	-0.1	1.9	1.3	1.8	2.2	-1.4	-1.9	-1.9	-1.8
Mean num. licks in bursts	0.2	0.7	1.8	-0.3	-1.3	-0.7	-1.0	-1.4	0.8	0.4	0.4	0.4
Cd content in liver	0.2	0.2	0.5	0.6	-0.2	0.7	0.3	-0.1	-0.6	-0.4	-0.4	-0.4
Co content in liver	0.3	0.3	2.4	1.5	0.2	-0.2	-0.2	-0.0	0.3	0.4	0.4	0.4
Cu content in liver	1.1	1.3	4.4	2.1	-0.5	-0.8	-1.4	-0.9	1.1	0.9	1.0	1.0
Fe content in liver	0.9	1.1	7.3	-2.7	0.2	0.1	1.4	0.7	-0.5	-0.1	-0.1	-0.1
K content in liver	0.1	0.1	0.3	0.0	-0.4	-0.3	-0.5	-0.5	0.4	0.0	-0.0	0.0
Mg content in liver	0.2	0.3	0.8	-0.0	-0.5	-0.4	-0.7	-0.9	0.6	0.3	0.3	0.3
Mn content in liver	0.1	0.1	0.6	0.8	-0.0	0.4	-0.2	-0.2	-0.3	-0.0	-0.0	-0.0
Na content in liver	0.6	0.7	1.1	-0.2	-0.6	-1.0	-0.8	-0.7	1.0	0.9	0.8	0.9
Rb content in liver	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.1	-0.3	0.2	0.1	0.2	0.2
Se content in liver	0.2	0.3	1.6	1.3	-0.2	0.4	0.1	0.2	-0.4	-0.5	-0.5	-0.5
Sr content in liver	1.2	1.0	5.3	2.3	-0.0	-0.7	-1.2	-0.0	0.7	0.7	0.7	0.7
Zn content in liver	0.3	0.3	0.9	0.7	-0.9	-0.1	-0.8	-1.0	0.4	0.0	0.0	0.0
Bone: minimum diameter	0.2	0.5	0.8	-0.3	0.6	0.7	0.8	0.3	-0.6	-0.9	-0.9	-0.8
Time in familiar zone, hab. session 1	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.0	-0.2	0.3	0.2	0.2	0.2
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.8	0.1	0.3	0.6	0.4	-0.6	-0.3	-0.3	-0.2
Total zone transitions, hab. session 1	0.3	0.4	2.6	1.6	-0.2	0.5	-0.7	-0.2	-0.4	-0.1	-0.1	0.2
Total locomotion distance, hab. session 1	0.3	0.4	1.3	1.1	-0.8	0.2	-0.8	-0.7	-0.0	0.1	0.1	0.3
Locomotion velocity, hab. session 1	0.3	0.4	1.6	1.3	-0.7	0.0	-0.9	-0.7	0.1	0.1	0.1	0.4
Time in familiar zone, hab. session 2	0.3	0.4	0.6	0.6	-0.8	-0.4	-0.6	-0.3	0.5	0.7	0.7	0.8
Time in novel zone, hab. session 2	0.3	0.3	0.6	0.1	0.8	0.5	0.4	0.2	-0.6	-0.7	-0.7	-0.8
Total zone transitions, hab. session 2	0.4	0.5	1.8	0.7	-0.5	0.2	-0.9	-1.3	0.2	0.6	0.6	0.8
Total locomotion distance, hab. session 2	0.2	0.2	0.7	0.6	0.5	0.8	0.1	-0.2	-0.6	-0.2	-0.2	-0.1
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.6	0.3	0.5	-0.2	-0.5	-0.3	0.1	0.1	0.2
Novel to familiar place preference ratio	0.2	0.3	0.9	-1.0	-0.5	0.4	0.4	0.0	-0.6	-0.4	-0.4	-0.3
Novelty place preference	0.2	0.2	0.9	-1.0	-0.8	0.3	0.3	-0.2	-0.4	-0.3	-0.3	-0.2
Time in novel zone, NPP test	0.2	0.3	1.0	-1.0	-0.9	0.3	0.2	-0.2	-0.4	-0.2	-0.2	-0.2
Total zone transitions, NPP test	0.4	0.5	2.4	1.5	-0.4	0.5	-0.9	-0.9	-0.1	0.2	0.2	0.4
Total locomotion distance, NPP test	0.1	0.1	0.6	0.3	-0.0	0.8	-0.2	-0.5	-0.5	-0.2	-0.2	-0.1
Locomotion velocity, NPP test	0.1	0.1	0.5	0.7	0.1	0.7	-0.3	-0.4	-0.4	-0.1	-0.1	-0.0
Intraocular pressure	0.2	0.4	0.7	-0.7	0.2	0.9	0.8	0.3	-0.6	-0.6	-0.6	-0.6
Delta distance traveled before/after self-admin	3.9	4.3	8.4	-1.6	-2.7	-1.5	-1.8	-2.9	1.8	1.9	1.9	1.9
Delta ambulatory time before/after self-admin	1.8	3.1	7.6	-1.7	-2.5	-1.0	-1.5	-2.8	1.5	1.4	1.4	1.5
Parametrial fat weight	1.9	4.4	7.5	-0.5	-2.4	-2.7	-1.9	-1.4	2.5	2.2	2.2	2.2
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.6	0.2	0.4	0.4	0.2	-0.5	-0.2	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.5	0.6	1.5	1.2	1.2	0.5	0.5	0.9	-0.5	-0.7	-0.6	-0.5
Pavlov. Cond. change in total contacts	0.5	0.6	2.7	1.6	0.8	0.7	-0.0	0.1	-0.4	-0.6	-0.6	-0.6
Pavlov. Cond. index score	0.1	0.1	0.7	0.9	0.3	-0.1	-0.1	-0.0	0.2	-0.2	-0.1	-0.1
Pavlov. Cond. latency score	0.1	0.1	0.6	0.7	0.2	-0.2	-0.1	0.1	0.2	-0.1	-0.1	-0.1
Pavlov. Cond. lever contacts	0.4	0.4	0.9	0.9	-0.2	-0.8	-0.8	-0.4	0.9	0.5	0.6	0.5
Pavlov. Cond. magazine entry number	0.2	0.3	1.9	-1.4	-0.6	-0.3	0.1	-0.1	0.1	0.4	0.3	0.2
Pavlov. Cond. intertrial magazine entries	1.6	1.9	3.0	-0.2	-1.4	-1.3	-1.7	-1.7	1.4	1.3	1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.9	1.0	0.2	-0.1	-0.2	-0.1	0.3	-0.1	-0.1	-0.1
Pavlov. Cond. response bias	0.2	0.2	1.5	1.2	0.4	-0.2	-0.3	-0.0	0.4	-0.0	0.0	0.1
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	0.0	0.8	0.3	-0.1	-0.6	-0.6	-0.6	-0.7
Pavlov. Cond. magazine entry latency	0.2	0.3	0.7	0.8	0.5	-0.4	-0.6	-0.1	0.3	0.6	0.6	0.6
Pavlov. Cond. change in total contacts	0.4	0.9	4.4	-2.1	0.2	-0.9	0.3	0.1	0.7	0.8	0.8	0.9
Pavlov. Cond. index score	0.3	0.5	0.9	-0.3	0.0	-0.9	-0.6	-0.3	0.8	0.9	0.9	1.0
Pavlov. Cond. latency score	0.5	0.7	1.2	-0.3	-0.1	-1.1	-0.8	-0.5	1.0	1.1	1.1	1.1
Pavlov. Cond. lever contacts	0.3	0.5	0.9	-0.5	-0.3	-0.9	-0.5	-0.2	0.8	0.8	0.8	0.9
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	0.2	-0.0	0.7	0.5	0.2	-0.5	-0.8	-0.8	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.4	1.0	-0.1	-0.6	-0.5	-0.7	-1.0	0.7	0.5	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.4	0.7	-0.3	0.2	-0.8	-0.4	0.0	0.6	0.8	0.8	0.8
Pavlov. Cond. response bias	0.1	0.2	0.4	-0.3	0.4	-0.5	-0.1	0.2	0.3	0.6	0.6	0.6
Time in closed arm before self-admin	0.3	0.4	1.2	0.4	0.2	-1.1	-0.5	0.0	0.7	0.8	0.8	0.8
Time in closed arm after self-admin	1.0	1.2	1.9	0.3	-0.8	-1.2	-1.1	-1.1	0.9	1.3	1.4	1.4
Time in open arm before self-admin	0.4	0.5	1.2	-0.3	-1.1	-0.6	-0.8	-1.1	0.8	0.5	0.4	0.4
Time in open arm after self-admin	0.0	0.0	0.0	0.1	-0.2	0.0	-0.1	0.0	0.1	0.0	-0.0	-0.0
Bone: periosteal estimation	0.4	1.0	2.0	-1.4	0.6	0.7	1.4	0.5	-0.7	-1.1	-1.1	-1.0
Bone: periosteal perimeter	0.4	0.8	3.3	-1.8	-0.0	0.4	1.3	0.0	-0.2	-0.8	-0.8	-0.7
Bone: post-yield work	0.2	0.3	0.7	0.3	0.5	0.8	0.5	-0.1	-0.4	-0.7	-0.7	-0.6
Progressive ratio test 1 active lever presses	1.3	2.4	4.6	1.0	1.9	2.1	1.2	1.0	-1.7	-1.5	-1.5	-1.5
Progressive ratio test 1 breakpoint	1.2	2.0	4.2	0.9	1.7	2.0	1.1	0.9	-1.6	-1.4	-1.4	-1.4
Progressive ratio test 1 inactive lever presses	0.8	2.1	6.8	0.7	2.6	1.3	1.4	1.7	-1.5	-0.9	-0.9	-0.9
Progressive ratio test 2 active lever presses	0.7	1.0	3.0	1.7	1.1	1.4	0.1	0.2	-0.9	-0.7	-0.7	-0.7
Progressive ratio test 2 breakpoint	1.0	1.3	3.2	1.8	1.3	1.6	0.4	0.4	-1.2	-0.9	-0.9	-0.9
Progressive ratio test 2 inactive lever presses	0.2	0.7	4.7	2.2	0.5	0.6	-0.7	-0.3	-0.3	-0.0	-0.0	-0.0
Incentive Sensitization - Responses	0.1	0.2	1.6	1.3	-0.0	0.2	-0.6	-0.3	0.0	0.1	0.1	0.1
Incentive Sensitization - Breakpoint	0.1	0.2	1.5	1.2	0.1	0.3	-0.5	-0.2	-0.1	0.1	0.1	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	-0.0	0.3	-0.2	0.3	0.6	0.0	-0.1	-0.0	-0.0
Progressive ratio	0.1	0.3	0.6	-0.5	0.8	0.5	0.6	0.7	-0.7	-0.2	-0.4	-0.4
Food seeking constrained by brief footshock	0.8	1.0	1.6	0.9	0.8	1.1	0.9	0.5	-0.9	-1.3	-1.2	-1.3
Seeking ratio, punishment vs. effort	0.0	0.1	0.5	0.7	-0.1	-0.0	0.0	-0.3	0.2	-0.3	-0.1	-0.1
Retroperitoneal fat weight	0.3	1.2	7.2	-2.7	-0.5	-1.0	1.1	0.8	0.6	0.0	0.0	-0.1
Reaction time number correct	0.1	0.4	1.2	1.1	-0.8	0.5	-0.6	-0.7	-0.1	0.2	0.2	0.2
Reaction time mean minus median	0.0	0.1	0.2	-0.3	0.4	0.1	0.3	0.4	-0.5	0.1	0.1	0.1
Reaction time mean minus median AUC	0.0	0.1	0.3	-0.6	0.1	-0.2	0.2	0.3	-0.2	0.4	0.4	0.4
Reaction time num false alarms	0.0	0.1	0.2	0.3	-0.4	-0.0	-0.2	-0.3	0.1	-0.3	-0.3	-0.3
Reaction time num false alarms AUC	0.1	0.1	0.3	0.3	-0.4	0.2	-0.2	-0.3	-0.0	-0.5	-0.5	-0.6
Reaction time trials correct on left	0.1	0.4	1.2	1.1	-0.8	0.5	-0.6	-0.7	-0.1	0.2	0.2	0.2
Reaction time trials on left	0.1	0.4	1.5	1.2	-0.7	0.6	-0.6	-0.7	-0.2	0.1	0.1	0.1
Reaction time mean	0.1	0.2	1.2	-1.1	0.2	-0.6	0.2	0.4	0.2	0.3	0.3	0.4
Reaction time mean AUC	0.1	0.1	0.7	-0.8	0.2	-0.4	0.2	0.3	0.1	0.2	0.3	0.3
Median of all reaction times	0.2	0.2	1.3	-1.1	0.3	-0.5	0.3	0.5	0.3	0.2	0.2	0.2
Reaction time omissions	2.2	3.5	4.9	1.8	2.2	2.0	1.6	2.1	-2.1	-1.7	-1.7	-1.7
Reaction time false alarm rate	0.1	0.1	0.3	-0.2	0.1	-0.2	0.2	0.2	0.0	-0.5	-0.5	-0.6
Reaction time premature initiation rate	0.0	0.1	0.2	-0.1	0.5	0.0	0.3	0.1	-0.0	-0.3	-0.3	-0.3
Reaction time premature initiations	0.0	0.0	0.1	0.2	-0.0	0.2	-0.1	-0.4	-0.0	0.0	0.0	0.0
Std. dev. reaction times	0.0	0.1	0.6	-0.8	-0.0	-0.3	0.1	0.2	-0.1	0.4	0.4	0.5
Reaction time trials completed	0.1	0.4	1.5	1.2	-0.7	0.6	-0.6	-0.7	-0.2	0.1	0.1	0.1
Reaction time trials AUC	0.1	0.3	1.0	1.0	-0.7	0.6	-0.5	-0.6	-0.3	0.1	0.1	0.0
Run reversals in cocaine runway, females	0.9	1.0	1.4	-0.8	-1.2	-1.0	-0.8	-0.7	0.9	1.1	1.2	1.2
Run reversals in cocaine runway, males	0.6	0.6	1.7	-1.0	-0.4	1.3	0.0	-0.7	-0.9	-0.9	-0.7	-0.6
Latency to leave start box in cocaine runway	1.9	2.7	4.2	-1.2	1.6	1.4	2.0	2.0	-1.5	-1.5	-1.7	-1.6
Latency to leave start box in cocaine runway, F	1.5	1.9	3.2	-0.9	1.5	1.1	1.8	1.6	-1.0	-1.4	-1.5	-1.3
Latency to leave start box in cocaine runway, M	0.6	0.6	1.1	-0.9	0.6	0.6	0.9	1.0	-0.9	-0.4	-0.7	-0.8
Std. dev. time between licks in bursts	0.0	0.1	0.4	-0.6	0.1	0.0	0.0	-0.0	0.1	-0.2	-0.2	-0.2
Total sessions with >9 infusions	1.9	2.3	4.1	-0.1	1.8	2.0	1.6	1.1	-1.6	-1.6	-1.6	-1.6
Short access day 1 total inactive lever presses	0.2	0.5	3.3	-1.8	0.7	0.3	0.4	-0.2	-0.4	0.2	0.2	0.2
Short access day 10 total inactive lever presses	0.8	5.5	8.2	-1.6	-2.6	-2.4	-2.2	-2.9	2.4	2.2	2.2	2.2
Short access day 1 total infusions	0.0	0.1	0.3	-0.6	0.4	0.4	0.1	-0.3	-0.1	-0.1	-0.1	-0.1
Short access day 10 total infusions	1.4	2.3	4.5	0.1	1.7	2.1	1.5	1.0	-1.6	-1.6	-1.6	-1.6
Short access total infusions	1.7	2.5	4.6	0.3	1.9	2.1	1.4	1.0	-1.7	-1.6	-1.6	-1.6
Short access day 1 locomotion	0.1	0.1	0.5	-0.7	0.2	0.2	0.0	-0.4	-0.1	0.2	0.2	0.2
Short access day 10 total locomotion	0.4	1.5	2.4	0.4	-0.3	-1.6	-1.2	-1.1	1.5	1.4	1.4	1.4
Short access total locomotion	0.1	0.1	0.7	0.1	0.8	0.1	0.2	0.2	-0.2	0.1	0.1	0.1
One hour access (0.3 mA shock)	2.0	2.3	8.3	2.9	1.4	2.0	0.2	0.5	-1.2	-1.3	-1.3	-1.3
Compulsive drug intake	0.8	1.2	2.2	0.8	-1.0	-0.9	-1.5	-1.1	1.0	1.1	1.1	1.1
One hour access (shock baseline)	1.0	2.6	4.0	1.4	1.9	2.0	1.3	1.4	-1.7	-1.6	-1.6	-1.6
Social response proportion	4.5	5.7	10.4	-0.9	3.0	1.9	3.1	3.2	-2.4	-2.0	-2.0	-2.0
Social responses	1.1	1.4	1.9	0.2	1.4	1.3	1.2	1.1	-1.1	-1.3	-1.3	-1.3
Social time	0.4	0.6	2.5	1.6	1.2	0.5	0.2	0.5	-0.2	-0.5	-0.5	-0.5
Soleus weight	1.9	5.6	7.9	1.4	-1.8	-2.7	-2.7	-2.2	2.8	2.4	2.4	2.4
Bone: stiffness	0.1	0.2	0.9	-0.9	0.4	-0.3	0.7	0.2	0.3	0.0	0.1	0.1
Tibialis anterior weight	0.5	1.8	11.2	3.4	1.7	0.3	-0.1	1.3	-0.6	-0.3	-0.3	-0.3
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.7	0.3	0.7	0.5	0.6	0.8	-0.7	-0.4	-0.4	-0.4
Time to tail flick, vehicle, after self-admin	1.2	2.5	3.8	-0.8	-1.7	-1.6	-1.5	-1.6	1.3	1.9	1.8	1.8
Time to tail flick, test, before self-admin	0.5	0.6	1.8	1.3	0.5	0.9	0.2	0.6	-0.9	-0.6	-0.6	-0.6
Time to tail flick, test, after self-admin	1.0	1.0	1.7	-0.1	-1.1	-0.9	-1.1	-1.1	1.0	1.3	1.0	1.0
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.9	-0.9	-0.3	-0.2	-0.2	-0.5	0.2	0.4	0.3	0.3
Delta time to tail flick, test, before/after SA	1.4	1.7	2.5	0.1	-1.2	-1.6	-1.3	-1.0	1.5	1.6	1.4	1.4
Tibia length	0.1	0.2	0.9	-1.0	0.2	0.2	0.7	0.1	-0.0	-0.3	-0.3	-0.4
Ambulatory time before self-admin	0.2	0.7	1.9	0.8	1.4	0.6	0.6	1.1	-0.7	-0.6	-0.6	-0.6
Ambulatory time after self-admin	0.6	1.0	2.5	-0.3	-1.1	-0.7	-1.1	-1.6	1.1	0.7	0.9	0.9
Bone: tissue strength	0.1	0.1	0.4	-0.7	0.1	-0.2	0.4	0.3	-0.0	0.2	0.2	0.3
Total heroin consumption	1.6	1.8	2.7	1.4	1.2	1.6	0.8	0.8	-1.2	-1.6	-1.6	-1.6
Bone: trabecular number	0.0	0.1	0.2	-0.3	-0.5	-0.3	-0.2	-0.1	0.4	0.2	0.2	0.2
Bone: trabecular spacing	0.3	0.4	0.8	-0.6	-0.2	-0.3	-0.0	-0.8	0.5	0.8	0.9	0.9
Bone: trabecular thickness	0.1	0.2	0.5	0.3	-0.4	-0.7	-0.6	-0.1	0.6	0.3	0.3	0.3
Bone: trabecular tissue density	0.8	1.5	2.7	0.0	-0.9	-1.6	-1.1	-0.6	1.4	1.3	1.4	1.5
Water consumed over 24 hours	0.8	1.5	3.8	0.7	-1.4	-0.9	-1.7	-2.0	1.2	0.8	0.8	0.8
Number of responses in last shaping day	2.4	3.0	6.5	1.4	2.6	1.9	1.4	1.7	-1.9	-1.5	-1.5	-1.5