Hub : Genes

C2h4orf54

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	C2h4orf54	0.28	0.12	5.4e-04	0.1	0.07	0.09	0.08	2.7e-03	9.1e-03	4.5e-03	7.2e-03
2	Brain	gene expression	C2h4orf54	0.08	0.04	1.9e-07	0.06	0.07	0.07	0.08	4.0e-06	3.8e-07	9.2e-07	1.3e-07
3	PL	mRNA stability	C2h4orf54	0.03	0.02	5.6e-03	0.01	0.02	0.01	0.01	3.7e-02	1.5e-03	3.8e-02	1.4e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.9	1.6	1.8	-1.3	1.3	-1.1
Area under the delay curve	0.1	0.1	0.2	-0.3	0.3	0.4
BMI with tail	1.3	4.4	7.4	2.7	-2.3	-0.7
BMI without tail	1.2	3.6	5.8	2.2	-2.4	-0.3
Body weight	1.7	7.4	11.9	3.5	-3.1	-0.7
Weight adjusted by age	0.1	0.2	0.6	-0.0	-0.1	0.8
Bone surface	0.4	0.8	1.1	-1.1	0.8	-0.7
Bone volume	0.3	0.6	1.3	-1.2	0.5	-0.4
Breakpoint value in progressive ratio session	0.8	1.0	1.8	1.0	0.2	-1.3
Number of licking bursts	1.1	1.7	3.9	2.0	-0.4	-1.1
Context. condit. distance diff. score	0.7	0.8	1.7	0.4	0.8	-1.3
Locomotion velocity, session 1	2.4	2.6	3.5	1.4	-1.9	1.5
Locomotion distance, session 1	2.1	2.7	4.4	2.1	-1.5	1.2
Locomotion velocity, session 2	0.1	0.1	0.1	0.2	-0.3	0.4
Locomotion distance, session 2	3.0	4.1	5.9	1.8	-1.8	2.4
Locomotion velocity, session 3	1.9	2.2	2.8	1.6	-1.7	1.1
Locomotion distance, session 3	0.1	0.2	0.4	0.6	-0.3	0.1
Stereotopy head waving bouts, day 3	1.3	1.6	2.3	1.1	-1.5	1.1
Stereotopy head waving duration, day 3	1.5	1.8	2.9	1.4	-1.7	0.5
Locomotion velocity, session 7	1.1	1.3	2.7	1.6	-1.0	0.2
Locomotion distance, session 7	0.8	1.0	2.5	1.6	-0.1	-0.8
Stereotopy head waving bouts, day 7	2.0	2.3	5.1	-0.9	-1.0	2.3
Stereotopy head waving duration, day 7	2.4	2.9	6.9	-0.7	-1.2	2.6
Locomotion velocity, session 8	0.2	0.2	0.3	0.6	-0.3	0.5
Locomotion distance, session 8	1.8	2.6	6.3	2.5	-1.1	0.5
Degree of sensitization distance	0.8	0.8	1.8	0.7	0.6	-1.3
Degree of sensitization stereotypy	2.1	2.2	4.2	-1.5	-0.6	2.0
Conditioned locomotion	1.5	1.8	3.9	-2.0	0.4	1.2
Cocaine response after cond. corrected	0.2	0.2	0.5	-0.7	-0.1	0.2
Cocaine response after cond. not corrected	0.4	0.5	1.2	-1.1	0.4	0.0
Cocaine response before conditioning	0.0	0.0	0.1	0.1	0.2	-0.1
Saline control response	1.6	2.1	4.5	0.3	-1.3	2.1
Bone: connectivity density	1.8	2.9	4.4	-1.4	2.1	-1.5
Bone: cortical apparent density	0.2	0.3	0.7	0.9	-0.3	-0.2
Bone: cortical area	0.7	1.1	1.6	0.8	-1.0	-1.2
Bone: cortical porosity	0.8	0.9	1.5	0.3	-1.2	1.0
Bone: cortical porosity	1.2	1.3	2.5	0.6	-1.6	1.1
Bone: cortical thickness	0.7	1.2	2.5	0.8	-0.8	-1.6
Bone: cortical thickness	0.3	0.3	0.7	0.1	-0.8	-0.4
Bone: cortical tissue density	0.2	0.3	0.8	0.9	-0.4	-0.2
Condit. Reinf. active minus inactive responses	2.6	2.9	5.7	2.4	-1.7	0.6
Condit. Reinf. active-inactive response ratio	5.5	5.8	11.7	3.4	-2.4	0.1
Condit. Reinf. active responses	1.1	1.3	1.6	1.2	-1.0	1.3
Condit. Reinf. inactive responses	1.5	1.9	3.4	-1.9	0.8	1.2
Incentive salience index mean	1.3	1.6	3.3	1.8	-1.2	0.1
Condit. Reinf. lever presses	0.0	0.0	0.1	0.1	-0.2	-0.2
Condit. Reinf. active minus inactive responses	0.2	0.3	0.7	-0.4	0.0	-0.8
Condit. Reinf. active-inactive response ratio	0.6	0.7	2.0	0.3	0.1	-1.4
Condit. Reinf. active responses	0.1	0.2	0.5	-0.1	-0.3	-0.7
Condit. Reinf. inactive responses	0.2	0.3	0.6	0.4	-0.8	0.4
Condit. Reinf. lever presses	0.4	0.5	1.5	-0.1	0.1	-1.2
Condit. Reinf. lever reinforcers received	0.1	0.2	0.5	-0.3	-0.1	-0.7
Conditioned reinforcement - actives	0.4	0.7	2.0	0.2	-0.3	1.4
Conditioned reinforcement - inactives	0.4	0.6	1.0	-0.8	0.3	1.0
Conditioned locomotion	1.7	2.2	3.5	-1.8	1.9	-0.3
Patch foraging indifference point 0 sec	0.4	0.7	1.7	-0.4	1.3	-0.6
Patch foraging indifference point AUC	0.4	0.6	1.6	0.6	-0.0	-1.3
Delay disc. indifference point, 0s delay	1.2	1.3	2.1	-1.5	1.3	-0.4
Delay disc. indifference point, 16s delay	0.1	0.1	0.4	0.6	-0.2	0.0
Delay disc. indifference point, 2s delay	1.8	2.0	4.2	-2.0	1.2	0.5
Delay disc. indifference point, 24s delay	0.6	0.7	1.4	-1.2	0.8	0.2
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	-0.3	0.6	-0.2
Delay disc. indifference point, 8s delay	1.1	1.3	3.0	0.5	-0.9	1.7
Indifference point function ln k	0.6	1.0	1.7	1.3	-0.9	0.8
Indifference point function log k	0.6	1.0	1.7	1.3	-0.9	0.8
Patch foraging total patch changes 0 sec	0.3	0.6	1.4	-0.1	1.2	-0.7
Patch foraging total patch changes 12 sec	0.4	0.5	1.3	0.2	0.5	-1.2
Patch foraging total patch changes 18 sec	0.4	0.6	1.2	0.2	0.8	-1.1
Patch foraging total patch changes 24 sec	0.1	0.1	0.2	0.5	-0.3	0.2
Patch foraging total patch changes 6 sec	2.2	3.3	7.7	0.0	1.5	-2.8
Patch foraging time to switch 0 sec	0.5	1.0	2.1	-1.4	0.6	0.8
Patch foraging water rate 0 sec	0.4	0.8	1.5	1.0	-0.2	-1.2
Patch foraging water rate 12 sec	1.2	2.6	4.4	2.1	-1.8	0.2
Patch foraging water rate 18 sec	1.3	2.0	3.5	1.5	-0.3	-1.9
Patch foraging water rate 24 sec	1.6	2.3	4.8	2.2	-0.7	-1.2
Patch foraging water rate 6 sec	5.0	7.3	15.3	3.9	-2.5	-0.3
Seeking ratio, delayed vs. immediate footshock	2.8	3.4	6.5	-2.5	2.0	0.1
Distance traveled before self-admin	0.1	0.1	0.3	-0.6	0.1	0.2
Distance traveled after self-admin	0.0	0.0	0.0	0.1	0.2	-0.0
Extensor digitorum longus weight	3.0	11.9	25.2	3.0	-5.0	1.4
Bone: elastic displacement	0.3	0.4	0.7	0.5	-0.9	-0.3
Bone: elastic work	1.1	1.5	1.8	1.3	-1.3	-1.0
Bone: endosteal estimation	0.0	0.1	0.1	0.3	-0.4	0.1
Bone: endosteal perimeter	0.2	0.4	0.7	0.4	-0.9	0.4
Epididymis fat weight	0.5	1.8	3.4	1.8	-1.3	-0.4
Delta time in closed arm before/after self-admin	1.4	1.3	1.6	1.2	-1.0	1.3
Delta time in open arm before/after self-admin	1.5	1.5	3.4	-0.6	-0.9	1.8
Diff in mean of infusions in LGA sessions	1.3	1.6	3.1	0.6	1.1	-1.8
Delay discount exponential model param	0.1	0.1	0.2	0.4	-0.3	-0.4
Extinction: sum of active levers before priming	0.4	0.5	1.2	0.5	-0.0	-1.1
Active lever presses in extinction session 6	1.1	1.1	2.2	-0.1	1.5	-1.1
Bone: final force	0.4	0.6	0.9	1.0	-0.5	-0.8
Bone: final moment	0.4	0.6	0.9	0.8	-0.4	-0.9
Food consumed during 24 hour testing period	1.1	1.5	2.4	1.5	-1.5	0.4
Glucose	1.0	1.5	2.9	1.7	-1.0	-0.8
Heart weight	0.5	0.7	1.6	0.8	-1.3	-0.2
Delay discount hyperbolic model param	0.2	0.2	0.3	0.6	-0.5	-0.4
Intermittent access intake day 1-15 change	0.2	0.3	0.6	-0.8	0.7	0.1
Intermittent access intake escalation	0.5	1.1	1.6	-1.2	1.3	-0.5
Intermittent access intake escalation 2	0.9	1.0	1.2	-0.8	1.1	-1.0
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.5	0.6	-0.7	0.5
Intermitt. access day 15 inactive lever presses	0.4	0.7	1.4	0.5	-1.2	0.7
Intermitt. access escalation Index	0.3	0.4	0.8	-0.4	-0.6	0.9
Intermittent access day 1 total infusions	1.0	1.6	3.1	1.8	-1.3	0.2
Intermittent access day 15 total infusions	0.2	0.3	0.6	0.8	-0.1	-0.6
Intermittent access terminal intake (last 3 days)	0.7	0.9	2.3	1.5	-0.5	-0.3
Intermittent access total infusions	1.2	1.5	3.5	1.9	-0.9	-0.2
Intermittent access day 1 locomotion	0.5	0.6	1.3	1.2	-0.7	-0.3
Intermittent access day 15 total locomotion	0.4	0.7	1.0	-0.6	1.0	-0.9
Intermittent access total locomotion	0.2	0.2	0.7	0.2	0.2	-0.8
Intermittent access standard deviation	0.2	0.4	0.8	0.7	-0.0	-0.9
Left kidney weight	0.6	2.7	4.2	2.0	-2.1	-0.3
Right kidney weight	0.6	2.6	4.2	1.9	-2.0	-0.2
Cocaine induced anxiety	0.2	0.3	0.5	0.1	0.5	-0.7
Post-drug Anxiety	0.3	0.4	0.6	-0.5	0.8	-0.5
Baseline Anxiety	0.1	0.2	0.3	0.3	-0.5	0.3
Tail length	0.0	0.2	0.6	0.1	-0.7	0.1
Length with tail	0.4	1.6	2.4	1.5	-1.6	-0.3
Length without tail	0.2	0.8	1.5	1.2	-0.8	-0.5
Times rat made contact with spout	0.5	0.5	1.3	0.3	0.5	-1.1
Lifetime Intake	1.2	1.5	3.4	1.9	-1.0	0.2
Liver weight, left	0.1	0.2	0.4	0.7	-0.4	-0.1
Liver weight, right	0.4	0.7	1.5	0.9	0.0	-1.2
Locomotor activity	0.1	0.1	0.2	0.5	0.1	-0.3
Locomotor testing distance	0.2	0.3	0.8	0.9	-0.5	0.2
Locomotor testing rearing	1.0	2.1	4.0	2.0	-0.1	-1.5
Locomotion in novel chamber	6.1	7.8	11.4	-3.0	3.4	-1.8
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	-0.5	0.2	0.7
Fecal boli incidents, locomotor time 1	0.4	0.6	1.5	0.2	-0.4	1.2
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	0.7	-0.3	-0.6
Time >=10cm from walls, locomotor time 1	2.9	3.1	6.5	-0.2	1.6	-2.5
Bouts of movement, locomotor time 1	0.6	0.6	1.7	-0.0	0.5	-1.3
Total resting periods, locomotor time 1	0.2	0.3	0.7	0.3	0.2	-0.8
Rest time, locomotor task time 1	0.4	0.5	1.2	-0.5	-0.4	1.1
Distance moved, locomotor task time 1	0.1	0.1	0.3	0.3	0.0	-0.6
Vertical activity count, locomotor time 1	0.2	0.4	0.7	-0.3	0.6	-0.9
Time >=10cm from walls, locomotor time 2	1.0	1.5	2.4	1.1	-1.5	0.9
Bouts of movement, locomotor time 2	0.7	1.2	1.8	-1.2	1.4	-0.4
Total resting periods, locomotor time 2	0.7	1.3	2.0	-1.3	1.4	-0.4
Rest time, locomotor task time 2	0.9	1.1	2.8	-1.7	0.8	0.1
Distance moved, locomotor task time 2	0.1	0.1	0.2	0.4	-0.3	0.4
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.1	-0.0	0.1
Light reinforcement 1	0.9	2.1	3.9	2.0	-1.6	0.0
Light reinforcement 2	0.0	0.0	0.1	0.0	-0.3	0.2
Bone: marrow area	0.0	0.0	0.1	0.2	-0.3	0.0
Bone: maximum diameter	0.2	0.3	0.7	0.2	-0.3	-0.8
Bone: maximum force	0.5	0.9	1.2	1.1	-0.4	-1.1
Bone: maximum moment	0.5	0.8	1.5	0.9	-0.2	-1.2
Mean time between licks in bursts	0.2	0.5	0.9	0.7	0.2	-1.0
Mean num. licks in bursts	0.6	1.0	2.5	-1.6	0.6	0.2
Cd content in liver	0.8	0.9	1.8	0.9	-0.2	-1.3
Co content in liver	4.4	5.1	7.6	2.8	-2.5	1.1
Cu content in liver	1.6	1.9	3.0	-0.4	1.7	-1.6
Fe content in liver	1.5	1.8	4.1	-2.0	1.0	0.5
K content in liver	1.5	1.4	2.2	-1.2	1.5	-0.8
Mg content in liver	0.4	0.4	0.7	0.1	0.8	-0.7
Mn content in liver	0.4	0.4	1.1	-0.2	0.4	-1.1
Na content in liver	0.3	0.4	0.5	-0.6	0.7	-0.5
Rb content in liver	0.1	0.1	0.3	0.1	-0.2	0.5
Se content in liver	0.4	0.4	1.0	-1.0	0.4	0.3
Sr content in liver	0.1	0.1	0.2	-0.4	0.0	0.3
Zn content in liver	19.9	22.0	36.2	-2.7	6.0	-4.8
Bone: minimum diameter	1.5	2.7	5.0	1.8	-2.2	-0.0
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.1	-0.2	0.6
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	0.3	-0.1
Total zone transitions, hab. session 1	3.2	4.5	5.7	1.8	-2.1	2.4
Total locomotion distance, hab. session 1	0.4	0.5	0.7	0.9	-0.5	0.8
Locomotion velocity, hab. session 1	0.4	0.5	1.2	1.1	-0.5	0.3
Time in familiar zone, hab. session 2	0.5	0.5	0.8	-0.9	0.2	-0.9
Time in novel zone, hab. session 2	0.2	0.3	0.6	0.4	0.1	0.8
Total zone transitions, hab. session 2	1.9	2.4	3.5	1.9	-1.5	1.2
Total locomotion distance, hab. session 2	0.5	0.7	1.8	1.3	-0.6	-0.0
Locomotion velocity, hab. session 2	0.4	0.6	1.5	1.2	-0.4	0.0
Novel to familiar place preference ratio	0.1	0.1	0.2	0.4	-0.0	-0.0
Novelty place preference	0.1	0.1	0.2	0.5	-0.0	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	-0.0	-0.2
Total zone transitions, NPP test	2.0	2.9	4.8	2.2	-1.8	0.8
Total locomotion distance, NPP test	0.5	0.7	1.5	1.2	-0.2	-0.8
Locomotion velocity, NPP test	0.7	1.0	1.9	1.4	-0.3	-0.9
Intraocular pressure	0.4	0.6	1.6	-1.3	0.2	0.5
Delta distance traveled before/after self-admin	0.3	0.4	1.0	1.0	-0.1	-0.1
Delta ambulatory time before/after self-admin	0.4	0.5	1.2	1.1	0.0	-0.6
Parametrial fat weight	0.2	0.5	1.1	0.0	0.7	-1.0
Pavlov. Cond. lever latency	0.8	1.0	1.5	1.1	-1.2	0.5
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	-0.0	-0.5	0.9
Pavlov. Cond. change in total contacts	0.1	0.1	0.4	0.1	0.2	0.6
Pavlov. Cond. index score	0.3	0.4	0.5	-0.7	0.7	-0.2
Pavlov. Cond. latency score	0.5	0.6	1.0	-0.9	1.0	-0.3
Pavlov. Cond. lever contacts	0.6	0.7	0.9	-0.7	1.0	-0.8
Pavlov. Cond. magazine entry number	0.5	0.7	0.9	-0.6	0.9	-0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.3	0.7	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.6	-0.6	0.8	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.1	-0.2	0.4
Pavlov. Cond. lever latency	0.9	1.2	2.2	-1.5	1.0	0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.3	0.2	0.3
Pavlov. Cond. change in total contacts	0.3	0.5	1.0	0.6	0.1	-1.0
Pavlov. Cond. index score	0.1	0.2	0.4	-0.2	0.2	-0.6
Pavlov. Cond. latency score	0.2	0.3	0.5	-0.3	0.5	-0.7
Pavlov. Cond. lever contacts	0.7	1.0	1.6	1.3	-1.1	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	0.3	-0.3	0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.9	-0.2	0.0	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.4	-0.2	0.3	-0.7
Pavlov. Cond. response bias	0.7	1.0	1.7	1.1	-1.3	0.0
Time in closed arm before self-admin	0.2	0.2	0.4	0.3	0.3	-0.6
Time in closed arm after self-admin	0.7	0.7	1.3	0.6	0.8	-1.1
Time in open arm before self-admin	0.3	0.4	0.8	0.5	-0.1	-0.9
Time in open arm after self-admin	0.8	0.8	1.6	-0.5	-0.8	1.3
Bone: periosteal estimation	0.3	0.7	1.2	0.9	-1.1	-0.5
Bone: periosteal perimeter	0.4	0.8	1.9	0.6	-1.4	0.2
Bone: post-yield work	0.3	0.4	1.0	-0.3	1.0	-0.3
Progressive ratio test 1 active lever presses	3.5	4.4	6.8	2.6	-2.2	1.2
Progressive ratio test 1 breakpoint	3.3	4.1	6.9	2.6	-2.1	1.0
Progressive ratio test 1 inactive lever presses	0.3	0.5	0.8	0.4	-0.7	0.9
Progressive ratio test 2 active lever presses	1.7	2.0	2.9	1.7	-1.7	0.7
Progressive ratio test 2 breakpoint	1.4	1.7	2.5	1.6	-1.5	0.5
Progressive ratio test 2 inactive lever presses	0.4	0.7	1.4	0.3	-0.8	1.2
Incentive Sensitization - Responses	0.3	0.4	1.0	-1.0	0.5	0.1
Incentive Sensitization - Breakpoint	0.3	0.4	1.0	-1.0	0.5	0.0
Sum of active levers in priming session hrs 5-6	2.3	2.1	4.1	-0.5	1.5	-2.0
Progressive ratio	0.2	0.3	0.4	-0.6	-0.4	0.5
Food seeking constrained by brief footshock	1.2	1.5	2.1	1.5	-0.9	-1.2
Seeking ratio, punishment vs. effort	0.6	0.9	1.9	1.4	-0.1	-0.8
Retroperitoneal fat weight	0.2	0.9	1.1	1.1	-0.9	-0.9
Reaction time number correct	0.1	0.2	0.3	0.6	-0.4	-0.1
Reaction time mean minus median	0.5	1.3	3.0	-1.7	0.6	0.8
Reaction time mean minus median AUC	0.4	1.1	2.6	-1.6	0.7	0.5
Reaction time num false alarms	1.6	2.3	6.1	-0.4	-0.8	2.5
Reaction time num false alarms AUC	1.7	2.7	6.7	-0.2	-1.2	2.6
Reaction time trials correct on left	0.1	0.2	0.3	0.6	-0.4	-0.1
Reaction time trials on left	0.1	0.1	0.2	0.4	-0.3	-0.1
Reaction time mean	0.4	0.7	1.6	-1.2	0.2	0.6
Reaction time mean AUC	0.4	0.6	1.2	-1.1	-0.1	0.8
Median of all reaction times	0.2	0.2	0.4	-0.6	-0.2	0.5
Reaction time omissions	1.9	2.8	6.3	-2.5	1.2	0.8
Reaction time false alarm rate	1.1	1.5	3.9	-0.6	-0.6	2.0
Reaction time premature initiation rate	1.5	2.1	3.9	1.0	-2.0	1.1
Reaction time premature initiations	1.6	2.9	5.2	1.3	-2.3	1.3
Std. dev. reaction times	1.1	2.1	4.7	-2.2	1.0	0.6
Reaction time trials completed	0.1	0.1	0.2	0.4	-0.3	-0.1
Reaction time trials AUC	0.1	0.2	0.4	0.6	-0.4	-0.1
Run reversals in cocaine runway, females	0.0	0.0	0.1	0.1	0.3	-0.2
Run reversals in cocaine runway, males	0.6	0.6	1.2	1.1	-0.7	0.5
Latency to leave start box in cocaine runway	0.4	0.4	0.8	-0.0	0.9	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	0.4	0.2	-0.3
Latency to leave start box in cocaine runway, M	1.4	1.3	2.3	-0.7	1.5	-1.1
Std. dev. time between licks in bursts	0.5	0.7	1.9	1.4	0.1	-0.5
Total sessions with >9 infusions	1.4	1.7	2.8	1.7	-1.0	1.1
Short access day 1 total inactive lever presses	0.4	0.6	1.6	1.3	-0.3	-0.1
Short access day 10 total inactive lever presses	0.5	1.3	2.4	-1.5	1.1	0.6
Short access day 1 total infusions	0.7	0.9	1.3	1.2	-0.6	1.0
Short access day 10 total infusions	1.2	1.5	2.8	1.7	-1.0	0.9
Short access total infusions	1.5	1.9	3.6	1.9	-1.1	1.1
Short access day 1 locomotion	0.7	0.8	2.4	1.5	-0.3	-0.0
Short access day 10 total locomotion	0.1	0.2	0.4	0.3	0.4	-0.7
Short access total locomotion	0.2	0.2	0.3	0.5	0.5	-0.5
One hour access (0.3 mA shock)	0.1	0.2	0.4	0.2	0.2	-0.6
Compulsive drug intake	0.4	0.5	0.7	-0.8	0.4	-0.8
One hour access (shock baseline)	0.3	0.4	0.8	0.9	-0.5	0.3
Social response proportion	0.9	1.0	2.1	-1.4	0.6	0.7
Social responses	0.7	0.9	1.8	-0.6	0.8	-1.3
Social time	2.1	2.8	4.8	-2.2	1.8	-0.7
Soleus weight	0.7	2.2	4.3	1.1	-2.1	1.0
Bone: stiffness	0.6	0.9	1.7	1.3	-0.5	-0.9
Tibialis anterior weight	3.4	11.5	24.4	3.1	-4.9	1.0
Time to tail flick, vehicle, before self-admin	0.6	0.6	1.0	-1.0	0.5	0.8
Time to tail flick, vehicle, after self-admin	0.8	1.1	2.8	-1.7	0.6	0.4
Time to tail flick, test, before self-admin	1.1	1.2	2.7	-1.6	0.9	0.0
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	0.1	-0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.1	0.3	-0.3	-0.2
Delta time to tail flick, test, before/after SA	0.9	0.9	2.1	1.4	-0.8	-0.1
Tibia length	0.2	0.6	1.6	0.4	-1.3	-0.2
Ambulatory time before self-admin	0.2	0.2	0.5	-0.7	0.0	0.5
Ambulatory time after self-admin	0.1	0.1	0.2	-0.3	0.5	0.2
Bone: tissue strength	1.0	1.0	1.5	1.2	-0.2	-1.2
Total heroin consumption	0.5	0.5	1.1	-0.4	0.6	-1.1
Bone: trabecular number	0.8	1.4	2.8	-1.7	1.1	0.3
Bone: trabecular spacing	0.7	1.0	2.5	0.4	0.4	-1.6
Bone: trabecular thickness	0.5	0.6	1.3	-0.0	-0.6	1.2
Bone: trabecular tissue density	0.6	0.9	1.8	0.6	-0.8	1.3
Water consumed over 24 hours	0.3	0.3	0.6	0.8	-0.6	-0.2
Number of responses in last shaping day	3.2	3.5	5.4	1.2	-1.9	2.3