Hub : Genes

C2h4orf33

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression C2h4orf33 0.04 0.03 8.6e-04 0.01 0.01 0.01 0 4.1e-02 7.5e-03 9.5e-03 7.1e-02
2 pVTA mRNA stability C2h4orf33 0.06 0.04 2.4e-03 0.07 0.05 0.06 0.05 4.0e-04 4.1e-03 1.2e-03 2.6e-03
3 OFC mRNA stability C2h4orf33 0.18 0.13 2.0e-03 0.1 0.1 0.07 0.07 2.7e-03 2.7e-03 7.6e-03 9.6e-03
4 Adipose gene expression C2h4orf33 0.03 0.02 6.6e-04 0.02 0.02 0.01 0.02 3.7e-03 1.9e-03 1.6e-02 3.1e-03
5 BLA mRNA stability C2h4orf33 0.07 0.05 2.7e-03 0.03 0.01 0.02 0.01 1.5e-02 9.8e-02 2.5e-02 1.1e-01
6 PL isoform ratio XR_351654.4 0.05 0.04 1.9e-04 0.01 0.02 0.01 0.01 1.1e-02 3.3e-03 1.3e-02 1.2e-02
7 pVTA gene expression C2h4orf33 0.07 0.06 3.5e-03 0.05 0.04 0.02 0.04 3.7e-03 8.1e-03 6.1e-02 8.1e-03
8 Brain intron excision ratio chr2_124783582_124783672 0.03 0.03 3.9e-03 0.02 0.03 0.02 0.02 3.5e-03 1.2e-03 4.5e-03 3.6e-03
9 Brain mRNA stability C2h4orf33 0.14 0.07 0.0e+00 0.22 0.2 0.21 0.22 2.7e-20 1.3e-18 7.4e-19 9.6e-20
10 Brain alternative TSS XM_039102595.1 0.03 0.02 2.6e-03 0.03 0.02 0.02 0.02 1.1e-03 2.6e-03 8.4e-03 4.8e-03
11 PL mRNA stability C2h4orf33 0.04 0.03 7.3e-05 0.03 0.03 0.06 0.03 1.1e-04 1.0e-04 7.3e-07 1.1e-04
12 PL alternative polyA XM_006232308.4 0.04 0.03 6.5e-03 0 0.01 0 0.01 7.3e-02 2.6e-02 1.3e-01 5.6e-02
13 Brain alternative TSS XM_039102595.1 0.02 0.02 2.4e-03 0.02 0.02 0.03 0.02 3.4e-03 3.1e-03 2.0e-03 8.2e-03
14 BLA isoform ratio XR_351654.4 0.52 0.2 7.8e-03 -0 0.03 0.03 -0 3.4e-01 1.2e-02 1.1e-02 4.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.10.20.9-0.2-0.30.3-0.3-0.2-0.40.2-0.6-0.4-0.2-0.1-0.5-0.40.9
Area under the delay curve4.54.86.12.12.0-2.22.22.12.2-1.92.52.42.32.02.22.3-2.2
BMI with tail4.313.821.64.64.1-4.24.13.93.5-3.93.33.73.74.03.13.50.9
BMI without tail0.71.44.81.61.3-1.21.21.10.8-1.30.40.50.91.10.51.12.2
Body weight4.117.425.35.04.4-4.64.54.34.1-4.34.14.44.34.43.83.90.0
Weight adjusted by age2.32.63.3-1.6-1.81.6-1.6-1.6-1.81.7-1.7-1.4-1.6-1.6-1.8-1.7-0.3
Bone surface0.10.22.30.10.20.00.00.40.4-0.3-0.0-0.3-0.1-0.10.3-0.11.5
Bone volume0.10.11.70.10.20.10.00.30.2-0.2-0.1-0.2-0.00.10.1-0.21.3
Breakpoint value in progressive ratio session1.31.42.91.21.1-1.11.11.11.7-1.21.40.71.20.71.71.30.6
Number of licking bursts2.52.95.62.4-0.2-2.32.11.91.4-1.91.71.91.91.51.21.6-0.1
Context. condit. distance diff. score0.20.32.7-0.00.50.10.10.60.5-0.30.0-0.20.10.20.50.21.6
Locomotion velocity, session 10.10.10.20.1-0.3-0.1-0.0-0.5-0.30.1-0.1-0.2-0.2-0.3-0.3-0.2-0.3
Locomotion distance, session 11.41.72.71.61.3-1.51.41.21.4-1.41.41.31.31.31.31.2-0.3
Locomotion velocity, session 20.50.52.0-0.0-0.60.0-0.2-0.8-1.20.6-0.8-0.4-0.5-0.2-1.4-0.6-1.2
Locomotion distance, session 21.01.32.41.61.2-1.41.31.01.0-1.21.01.21.11.30.81.1-0.3
Locomotion velocity, session 30.30.31.2-0.3-0.10.4-0.4-0.3-0.50.4-0.6-1.1-0.6-0.7-0.5-0.50.9
Locomotion distance, session 30.60.61.60.91.3-0.90.91.00.8-0.90.70.10.70.50.70.90.2
Stereotopy head waving bouts, day 31.72.02.8-1.2-1.41.3-1.3-1.4-1.51.3-1.7-1.6-1.4-1.2-1.6-1.31.5
Stereotopy head waving duration, day 32.02.43.0-1.3-1.51.5-1.5-1.5-1.61.5-1.7-1.7-1.5-1.5-1.6-1.51.6
Locomotion velocity, session 70.10.10.3-0.3-0.20.4-0.4-0.20.10.3-0.1-0.2-0.3-0.40.2-0.10.6
Locomotion distance, session 70.50.61.1-1.1-0.61.0-0.9-0.7-0.60.9-0.7-0.8-0.9-0.9-0.5-0.80.3
Stereotopy head waving bouts, day 70.30.32.50.40.2-0.10.10.1-0.5-0.1-0.7-0.5-0.40.3-0.8-0.41.6
Stereotopy head waving duration, day 70.30.31.70.2-0.10.0-0.1-0.0-0.60.1-0.7-0.6-0.60.1-0.9-0.51.3
Locomotion velocity, session 82.12.53.61.81.8-1.61.61.91.6-1.71.41.51.61.81.51.50.7
Locomotion distance, session 81.21.72.81.51.7-1.31.31.61.4-1.41.11.01.21.41.21.21.0
Degree of sensitization distance1.21.22.0-1.4-1.31.3-1.2-1.2-1.11.3-0.9-0.5-0.9-0.9-0.9-1.1-0.4
Degree of sensitization stereotypy0.80.91.81.41.1-1.11.01.10.6-1.10.40.50.61.10.30.61.1
Conditioned locomotion0.10.11.2-0.10.40.1-0.00.30.1-0.2-0.3-0.6-0.1-0.0-0.1-0.11.1
Cocaine response after cond. corrected0.20.30.90.20.3-0.40.40.40.4-0.40.60.8-0.10.60.50.3-1.0
Cocaine response after cond. not corrected0.20.20.9-0.6-0.60.4-0.4-0.5-0.30.5-0.00.2-0.8-0.2-0.1-0.4-0.9
Cocaine response before conditioning2.42.94.1-1.9-2.01.9-1.9-1.8-1.41.8-1.6-1.8-1.5-2.0-1.3-1.61.2
Saline control response0.30.41.2-0.6-0.70.7-0.7-0.8-0.30.7-0.4-0.9-0.5-1.1-0.2-0.30.5
Bone: connectivity density0.30.52.8-0.5-0.60.7-0.6-0.5-0.40.4-0.8-0.9-0.5-0.6-0.5-0.51.7
Bone: cortical apparent density0.70.91.6-0.9-0.90.9-0.9-0.9-1.20.9-1.2-0.7-0.9-0.4-1.3-1.00.3
Bone: cortical area0.40.61.01.01.0-0.90.80.80.7-0.90.70.90.70.90.60.30.3
Bone: cortical porosity0.40.51.6-0.8-0.50.9-0.8-0.30.00.6-0.2-1.0-0.4-1.30.2-0.30.9
Bone: cortical porosity0.80.92.1-1.1-0.91.2-1.1-0.7-0.30.9-0.6-1.2-0.8-1.5-0.1-0.71.2
Bone: cortical thickness0.10.10.40.30.4-0.30.30.20.2-0.40.20.60.10.50.2-0.1-0.2
Bone: cortical thickness0.80.91.61.21.3-1.11.11.10.8-1.20.70.80.81.10.60.7-0.2
Bone: cortical tissue density0.60.81.6-0.9-0.90.9-0.9-0.9-1.20.9-1.2-0.6-0.9-0.4-1.2-1.00.3
Condit. Reinf. active minus inactive responses1.11.31.81.21.0-1.11.11.01.3-1.11.21.31.31.11.31.2-0.2
Condit. Reinf. active-inactive response ratio1.01.11.61.11.0-1.01.10.91.3-1.11.21.01.10.81.31.2-0.4
Condit. Reinf. active responses2.12.63.61.81.6-1.61.61.61.9-1.61.71.51.71.31.81.70.2
Condit. Reinf. inactive responses0.91.11.81.31.2-1.01.01.31.2-1.10.90.51.00.71.11.11.0
Incentive salience index mean1.92.33.11.71.5-1.61.61.51.5-1.51.51.81.71.61.41.5-0.7
Condit. Reinf. lever presses1.41.93.01.61.6-1.51.51.61.1-1.31.11.61.51.70.91.1-0.9
Condit. Reinf. active minus inactive responses3.84.78.01.92.2-1.92.12.32.8-2.22.51.82.11.72.82.50.4
Condit. Reinf. active-inactive response ratio8.08.411.12.62.9-2.82.93.13.3-3.13.22.93.02.93.33.1-0.7
Condit. Reinf. active responses0.30.51.40.50.5-0.50.50.61.1-0.51.00.50.50.31.20.80.3
Condit. Reinf. inactive responses1.21.52.1-0.9-1.31.1-1.3-1.3-1.11.4-1.1-1.2-1.4-1.4-1.1-1.30.6
Condit. Reinf. lever presses1.21.73.21.21.1-1.21.21.11.7-1.31.71.41.11.11.81.3-0.4
Condit. Reinf. lever reinforcers received0.20.31.20.40.3-0.40.40.51.0-0.40.90.40.40.11.10.70.2
Conditioned reinforcement - actives2.62.63.7-1.6-1.81.5-1.6-1.7-1.91.6-1.8-1.5-1.6-1.4-1.9-1.70.1
Conditioned reinforcement - inactives5.96.610.0-3.1-3.22.9-2.9-2.9-2.22.8-2.2-2.2-2.8-2.6-1.9-2.5-0.6
Conditioned locomotion0.50.61.0-0.6-1.00.7-0.7-0.9-0.90.7-0.9-0.7-0.8-0.6-1.0-0.9-0.3
Patch foraging indifference point 0 sec0.60.92.01.41.2-1.31.11.10.6-1.00.90.60.90.60.50.6-1.0
Patch foraging indifference point AUC1.11.31.7-1.0-1.21.2-1.2-1.2-0.81.2-1.2-1.3-1.0-1.3-0.9-1.21.2
Delay disc. indifference point, 0s delay0.20.30.8-0.2-0.50.3-0.4-0.6-0.80.5-0.6-0.3-0.5-0.3-0.9-0.4-0.4
Delay disc. indifference point, 16s delay2.52.55.01.31.2-1.41.41.42.0-1.52.11.71.51.22.21.5-1.4
Delay disc. indifference point, 2s delay4.04.45.72.42.3-2.42.32.21.9-2.22.02.12.12.21.82.2-0.8
Delay disc. indifference point, 24s delay2.22.13.41.11.2-1.31.31.41.7-1.41.81.81.51.41.81.4-1.2
Delay disc. indifference point, 4s delay0.50.51.50.80.6-0.70.60.50.4-0.40.70.90.80.60.50.8-1.2
Delay disc. indifference point, 8s delay2.82.97.11.51.5-1.71.61.51.5-1.31.92.01.81.51.61.7-2.7
Indifference point function ln k2.12.93.81.61.9-1.81.81.81.5-1.81.82.01.61.81.51.6-1.3
Indifference point function log k2.12.93.81.61.9-1.81.81.81.5-1.81.82.01.61.81.51.6-1.3
Patch foraging total patch changes 0 sec0.40.71.71.31.1-1.11.01.10.6-0.90.80.40.80.50.50.5-0.7
Patch foraging total patch changes 12 sec1.11.52.1-0.9-1.11.1-1.2-1.2-1.31.3-1.4-1.5-1.1-1.3-1.4-1.30.8
Patch foraging total patch changes 18 sec0.00.00.10.3-0.1-0.10.0-0.1-0.10.2-0.10.10.00.1-0.1-0.2-0.0
Patch foraging total patch changes 24 sec0.10.21.60.60.3-0.30.20.20.2-0.2-0.1-0.20.00.20.0-0.01.3
Patch foraging total patch changes 6 sec0.71.02.0-0.6-0.90.8-0.9-0.9-1.11.2-1.1-1.4-1.0-1.3-1.2-1.10.5
Patch foraging time to switch 0 sec0.30.53.60.30.2-0.60.50.2-0.0-0.20.50.90.40.8-0.00.6-1.9
Patch foraging water rate 0 sec0.61.06.2-0.6-0.40.9-0.8-0.5-0.40.4-0.9-1.3-0.7-1.0-0.5-0.82.5
Patch foraging water rate 12 sec0.20.30.6-0.2-0.80.3-0.4-0.7-0.60.4-0.6-0.5-0.6-0.4-0.7-0.50.0
Patch foraging water rate 18 sec0.10.10.30.50.2-0.40.3-0.0-0.1-0.40.00.20.20.3-0.20.30.2
Patch foraging water rate 24 sec0.20.31.70.3-0.10.1-0.1-0.2-0.70.1-0.8-0.4-0.1-0.1-1.0-0.41.3
Patch foraging water rate 6 sec0.10.10.30.60.2-0.40.40.2-0.0-0.2-0.00.40.20.6-0.2-0.00.4
Seeking ratio, delayed vs. immediate footshock0.20.31.70.30.3-0.10.20.20.7-0.30.30.50.50.30.70.51.3
Distance traveled before self-admin1.11.21.71.10.9-1.21.11.01.1-1.01.31.10.90.81.11.2-1.2
Distance traveled after self-admin0.80.92.31.10.8-1.11.00.80.7-0.91.10.90.60.70.80.8-1.5
Extensor digitorum longus weight1.56.19.63.12.6-2.82.72.62.6-2.62.42.22.62.32.32.40.3
Bone: elastic displacement0.10.10.4-0.5-0.20.3-0.2-0.20.10.20.20.1-0.1-0.30.3-0.1-0.6
Bone: elastic work0.00.10.4-0.20.20.00.00.20.2-0.00.30.40.10.20.30.0-0.6
Bone: endosteal estimation1.83.96.42.42.5-2.12.02.42.2-2.21.81.11.81.52.01.91.4
Bone: endosteal perimeter0.30.71.11.11.0-0.80.80.91.0-0.90.80.50.80.50.90.70.6
Epididymis fat weight1.73.95.82.42.3-2.12.12.01.9-2.11.81.82.12.01.71.81.0
Delta time in closed arm before/after self-admin0.40.44.1-0.2-0.20.4-0.3-0.20.00.2-0.4-0.6-0.2-0.3-0.0-0.32.0
Delta time in open arm before/after self-admin0.20.22.20.00.2-0.20.1-0.1-0.50.1-0.00.3-0.10.3-0.5-0.2-1.5
Diff in mean of infusions in LGA sessions2.02.33.91.41.5-1.31.41.52.0-1.61.71.31.41.32.01.50.6
Delay discount exponential model param5.05.26.5-2.2-2.22.3-2.3-2.2-2.32.0-2.6-2.5-2.4-2.1-2.3-2.42.2
Extinction: sum of active levers before priming0.80.82.50.70.6-0.60.70.61.5-0.81.20.50.90.21.60.90.1
Active lever presses in extinction session 61.51.42.01.31.2-1.31.31.11.4-1.11.41.01.30.91.41.3-0.6
Bone: final force0.00.10.50.30.2-0.10.00.00.3-0.10.20.1-0.1-0.00.3-0.00.7
Bone: final moment0.10.10.50.30.3-0.20.10.10.4-0.20.30.2-0.0-0.00.40.00.7
Food consumed during 24 hour testing period2.32.84.11.82.0-1.81.81.81.6-1.81.71.71.61.81.51.3-1.0
Glucose1.62.43.81.72.0-1.71.71.91.4-1.71.31.31.81.71.21.4-0.1
Heart weight0.81.12.40.81.1-0.70.81.11.5-1.01.10.61.00.71.51.11.3
Delay discount hyperbolic model param4.74.96.0-2.2-2.12.3-2.3-2.1-2.22.0-2.5-2.4-2.3-2.1-2.2-2.32.0
Intermittent access intake day 1-15 change0.10.10.3-0.5-0.20.3-0.3-0.3-0.20.2-0.2-0.2-0.0-0.3-0.20.10.0
Intermittent access intake escalation0.10.10.40.00.4-0.20.30.30.3-0.40.40.40.50.30.40.6-0.2
Intermittent access intake escalation 20.20.20.30.40.5-0.50.50.30.3-0.50.40.40.40.20.30.5-0.3
Intermitt. access day 1 inactive lever presses1.01.03.2-1.0-1.01.2-1.0-0.9-0.40.7-0.9-1.3-0.8-1.2-0.4-0.71.8
Intermitt. access day 15 inactive lever presses1.31.42.7-1.6-1.31.5-1.4-1.3-0.81.3-0.8-1.4-1.3-1.6-0.5-0.8-0.2
Intermitt. access escalation Index1.21.11.7-1.3-1.21.2-1.2-1.2-0.91.1-0.9-1.3-0.7-1.2-0.8-0.8-0.1
Intermittent access day 1 total infusions2.42.76.7-1.8-1.81.4-1.6-1.7-1.91.8-1.2-0.9-1.3-1.3-1.7-1.6-2.6
Intermittent access day 15 total infusions0.40.42.8-0.9-0.60.5-0.5-0.6-0.60.6-0.2-0.0-0.1-0.4-0.4-0.3-1.7
Intermittent access terminal intake (last 3 days)0.60.63.1-0.9-0.70.6-0.6-0.8-0.90.7-0.5-0.1-0.3-0.6-0.8-0.5-1.8
Intermittent access total infusions1.41.54.2-1.3-1.31.0-1.1-1.3-1.41.3-0.9-0.6-1.0-1.1-1.3-1.1-2.1
Intermittent access day 1 locomotion0.90.92.0-0.8-1.10.7-0.9-1.0-1.21.0-0.8-0.4-0.8-0.6-1.1-0.9-1.4
Intermittent access day 15 total locomotion0.10.10.9-0.2-0.40.2-0.2-0.4-0.40.3-0.20.1-0.2-0.2-0.3-0.1-1.0
Intermittent access total locomotion0.20.30.7-0.3-0.60.3-0.4-0.6-0.70.6-0.5-0.2-0.5-0.3-0.7-0.4-0.8
Intermittent access standard deviation0.70.73.50.60.7-0.80.70.60.5-0.70.91.00.50.70.50.6-1.9
Left kidney weight0.41.22.01.41.2-1.21.21.30.9-1.30.70.90.91.30.60.90.9
Right kidney weight1.64.66.42.52.5-2.22.32.52.1-2.31.71.82.22.31.81.81.6
Cocaine induced anxiety1.61.93.81.21.1-1.21.31.41.8-1.41.71.41.11.12.01.40.2
Post-drug Anxiety0.30.30.70.50.2-0.50.50.40.7-0.50.80.80.40.40.70.5-0.5
Baseline Anxiety1.21.31.9-1.1-1.11.1-1.1-1.2-1.31.1-1.4-1.2-1.1-1.1-1.4-1.20.6
Tail length0.10.21.7-0.20.00.3-0.30.0-0.00.2-0.3-0.8-0.2-0.5-0.1-0.11.3
Length with tail0.41.42.81.11.0-1.11.11.11.5-0.91.61.11.30.81.71.1-0.3
Length without tail1.32.84.91.51.2-1.61.51.41.9-1.22.22.11.81.42.11.4-1.7
Times rat made contact with spout0.30.40.70.90.6-0.80.80.70.4-0.60.40.50.60.70.20.4-0.2
Lifetime Intake1.71.96.1-1.4-1.51.1-1.2-1.4-1.51.4-0.9-0.6-1.2-1.1-1.4-1.3-2.5
Liver weight, left1.11.76.61.30.9-1.41.20.90.5-0.81.11.91.31.50.40.8-2.6
Liver weight, right0.30.51.4-0.3-0.70.4-0.5-0.7-1.00.7-0.9-0.6-0.6-0.3-1.2-0.7-0.1
Locomotor activity0.40.62.40.20.8-0.50.50.70.9-0.61.20.70.40.21.20.6-1.5
Locomotor testing distance0.71.12.60.81.1-0.90.90.91.1-0.91.50.80.80.31.40.9-1.6
Locomotor testing rearing0.20.30.9-0.5-0.30.5-0.5-0.2-0.20.4-0.3-0.9-0.6-0.9-0.1-0.40.5
Locomotion in novel chamber1.11.42.81.51.4-1.41.31.10.8-1.10.91.31.71.30.61.00.2
Locomotion in novel chamber post-restriction0.40.50.7-0.6-0.90.7-0.7-0.7-0.70.8-0.8-0.5-0.8-0.4-0.7-0.60.5
Fecal boli incidents, locomotor time 11.31.44.10.71.0-1.01.00.91.0-0.91.41.51.31.01.21.0-2.0
Change in fecal boli incidents, locomotor task1.11.01.6-1.1-1.31.1-1.1-1.2-0.81.2-0.9-1.1-1.2-1.1-0.7-0.80.4
Time >=10cm from walls, locomotor time 10.50.53.9-0.7-0.60.4-0.5-0.7-0.70.6-0.20.3-0.3-0.4-0.5-0.5-2.0
Bouts of movement, locomotor time 11.11.22.5-1.5-1.31.1-1.1-1.2-0.71.1-0.4-0.7-0.9-1.3-0.4-0.9-1.6
Total resting periods, locomotor time 11.21.32.7-1.6-1.31.2-1.2-1.2-0.91.2-0.5-0.7-1.0-1.3-0.6-1.0-1.6
Rest time, locomotor task time 10.30.33.20.10.3-0.40.40.20.0-0.30.40.50.10.30.10.1-1.8
Distance moved, locomotor task time 10.40.54.40.70.4-0.40.40.40.4-0.4-0.0-0.00.40.50.20.42.1
Vertical activity count, locomotor time 11.01.12.51.61.3-1.21.11.10.7-1.10.40.50.91.10.40.81.4
Time >=10cm from walls, locomotor time 20.80.98.20.40.6-0.70.70.50.1-0.50.70.70.50.60.20.5-2.9
Bouts of movement, locomotor time 24.54.96.3-2.5-2.42.4-2.3-2.3-2.12.3-2.2-2.4-2.3-2.3-2.0-2.00.9
Total resting periods, locomotor time 24.34.66.0-2.5-2.32.4-2.3-2.3-2.02.2-2.1-2.3-2.3-2.3-1.8-1.91.0
Rest time, locomotor task time 20.10.10.2-0.5-0.40.4-0.4-0.2-0.00.2-0.2-0.1-0.3-0.30.1-0.30.4
Distance moved, locomotor task time 20.80.92.01.41.1-1.31.21.00.6-1.00.70.70.91.10.40.80.1
Vertical activity count, locomotor time 20.91.03.01.71.4-1.41.31.10.3-1.10.40.40.81.1-0.10.60.3
Light reinforcement 10.00.10.2-0.4-0.30.3-0.2-0.30.10.30.20.1-0.2-0.20.30.0-0.4
Light reinforcement 20.10.10.7-0.4-0.50.2-0.1-0.10.20.20.20.40.1-0.00.40.1-0.8
Bone: marrow area2.14.47.32.52.7-2.22.22.52.3-2.41.91.22.01.62.12.01.4
Bone: maximum diameter0.10.10.50.60.4-0.30.30.40.1-0.3-0.00.10.20.3-0.0-0.20.7
Bone: maximum force0.40.61.01.01.0-0.90.80.80.8-0.80.90.80.70.80.80.60.1
Bone: maximum moment0.40.71.21.01.1-0.90.90.90.9-0.91.00.90.80.80.90.60.2
Mean time between licks in bursts1.72.44.81.71.6-1.81.61.40.9-1.41.42.01.51.90.81.0-2.2
Mean num. licks in bursts1.51.83.2-1.80.61.7-1.6-1.4-1.11.5-1.3-1.6-1.5-1.2-0.9-1.3-0.0
Cd content in liver0.80.91.6-1.1-0.91.0-1.0-1.0-0.90.9-0.9-1.3-1.0-1.2-0.8-0.90.1
Co content in liver0.10.10.90.10.1-0.20.20.20.2-0.10.50.60.20.20.30.2-0.9
Cu content in liver0.10.10.3-0.3-0.10.3-0.30.10.30.20.3-0.1-0.1-0.50.50.1-0.2
Fe content in liver0.20.20.8-0.10.40.00.10.40.8-0.40.5-0.00.2-0.10.90.40.7
K content in liver1.71.72.4-1.6-1.51.5-1.5-1.5-1.11.5-1.1-1.2-1.3-1.6-0.8-1.20.3
Mg content in liver0.60.71.5-1.1-0.81.0-1.0-0.9-0.50.9-0.4-0.8-0.6-1.2-0.2-0.6-0.2
Mn content in liver0.91.11.7-1.3-1.21.1-1.1-1.3-1.11.2-0.8-0.5-0.9-0.8-0.9-1.1-0.7
Na content in liver2.12.22.9-1.4-1.51.5-1.6-1.5-1.41.6-1.5-1.6-1.5-1.7-1.4-1.50.9
Rb content in liver2.22.74.9-2.0-1.91.9-1.9-1.8-1.21.9-1.1-1.5-1.7-2.2-0.8-1.4-0.3
Se content in liver1.72.12.5-1.6-1.51.5-1.5-1.4-1.61.6-1.5-1.4-1.5-1.5-1.5-1.50.0
Sr content in liver2.01.82.81.61.6-1.41.51.51.2-1.60.81.01.31.70.91.11.2
Zn content in liver0.10.20.50.00.4-0.10.20.50.6-0.20.5-0.10.3-0.20.70.50.3
Bone: minimum diameter0.91.62.41.41.4-1.21.21.31.6-1.41.41.11.21.01.61.10.5
Time in familiar zone, hab. session 10.50.41.0-0.6-0.60.5-0.6-0.5-0.80.9-0.5-0.0-0.8-0.3-0.8-0.7-1.0
Time in novel zone, hab. session 10.80.75.4-0.5-0.30.7-0.6-0.5-0.10.2-0.7-1.4-0.3-0.9-0.2-0.32.3
Total zone transitions, hab. session 11.21.73.71.31.2-1.31.21.31.3-1.21.31.91.21.71.31.1-0.4
Total locomotion distance, hab. session 10.10.10.50.20.1-0.10.1-0.00.3-0.20.10.40.20.30.30.10.7
Locomotion velocity, hab. session 10.10.20.50.50.3-0.30.40.20.5-0.40.40.70.40.60.50.30.3
Time in familiar zone, hab. session 24.44.55.4-2.3-2.22.2-2.2-2.2-2.32.3-2.2-1.8-2.3-1.9-2.2-2.30.1
Time in novel zone, hab. session 25.45.47.62.52.6-2.22.32.62.8-2.62.21.42.51.82.62.51.4
Total zone transitions, hab. session 20.30.51.00.90.6-0.80.70.40.5-0.60.61.00.80.80.40.5-0.3
Total locomotion distance, hab. session 20.40.51.20.90.7-0.80.80.40.8-0.70.70.81.10.60.70.70.3
Locomotion velocity, hab. session 20.20.20.50.60.3-0.50.50.10.4-0.40.40.70.70.50.40.4-0.1
Novel to familiar place preference ratio0.20.21.60.30.4-0.10.20.40.5-0.40.2-0.10.50.10.50.31.3
Novelty place preference0.20.22.0-0.00.10.2-0.10.10.3-0.1-0.1-0.40.3-0.20.2-0.01.4
Time in novel zone, NPP test0.30.33.50.10.20.1-0.00.20.4-0.2-0.1-0.50.3-0.30.30.11.9
Total zone transitions, NPP test0.10.10.3-0.1-0.40.1-0.2-0.5-0.20.2-0.00.2-0.3-0.1-0.1-0.2-0.5
Total locomotion distance, NPP test0.10.10.3-0.2-0.40.3-0.2-0.6-0.10.2-0.20.1-0.2-0.2-0.1-0.20.3
Locomotion velocity, NPP test0.20.30.9-0.5-0.70.5-0.5-0.9-0.50.5-0.4-0.0-0.6-0.3-0.5-0.6-0.4
Intraocular pressure4.35.99.12.53.0-2.62.62.82.1-2.62.22.32.72.71.92.2-1.5
Delta distance traveled before/after self-admin0.40.50.7-0.5-0.60.6-0.6-0.7-0.80.7-0.8-0.8-0.8-0.7-0.8-0.80.4
Delta ambulatory time before/after self-admin0.60.60.8-0.7-0.80.8-0.8-0.9-0.70.8-0.7-0.9-0.9-0.9-0.7-0.80.1
Parametrial fat weight0.61.21.91.41.0-1.31.21.31.0-1.11.11.31.01.20.91.1-0.5
Pavlov. Cond. lever latency1.51.94.4-1.6-1.21.6-1.4-1.1-0.51.1-1.0-2.0-1.4-2.0-0.3-0.72.1
Pavlov. Cond. magazine entry latency1.82.43.61.91.6-1.71.71.51.4-1.51.31.71.81.81.21.4-0.3
Pavlov. Cond. change in total contacts1.21.32.81.51.2-1.41.31.10.7-1.20.81.31.21.70.40.9-0.3
Pavlov. Cond. index score1.92.44.62.11.6-1.91.81.60.9-1.51.11.81.82.20.51.1-1.0
Pavlov. Cond. latency score1.31.73.51.71.3-1.61.41.30.6-1.10.81.71.51.90.30.8-1.3
Pavlov. Cond. lever contacts2.32.75.51.91.6-1.91.81.60.6-1.41.12.11.62.40.30.9-2.2
Pavlov. Cond. magazine entry number1.62.04.2-2.0-1.61.8-1.7-1.5-0.91.5-0.9-1.4-1.5-1.9-0.5-1.10.2
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.30.20.2-0.00.30.6-0.40.4-0.00.1-0.10.70.40.5
Pavlov. Cond. lever-magazine prob. diff.2.32.85.22.21.8-2.01.91.81.1-1.61.21.91.92.30.71.3-0.7
Pavlov. Cond. response bias3.94.78.22.82.4-2.62.52.31.5-2.21.62.42.32.91.11.8-1.0
Pavlov. Cond. lever latency0.30.30.8-0.7-0.30.5-0.5-0.4-0.90.6-0.8-0.6-0.4-0.4-0.9-0.6-0.4
Pavlov. Cond. magazine entry latency0.60.71.11.00.8-0.90.90.71.0-0.81.00.90.90.81.00.90.3
Pavlov. Cond. change in total contacts0.81.23.40.90.7-0.80.80.61.6-0.91.50.91.00.31.81.30.3
Pavlov. Cond. index score1.21.62.41.51.0-1.31.21.01.5-1.31.51.21.21.01.61.30.4
Pavlov. Cond. latency score1.51.82.61.61.1-1.41.41.11.6-1.41.61.41.41.21.61.40.1
Pavlov. Cond. lever contacts0.20.21.00.50.2-0.30.30.20.7-0.40.50.20.20.10.70.31.0
Pavlov. Cond. magazine entry number1.41.82.8-1.5-1.21.3-1.3-1.1-1.71.3-1.5-1.1-1.4-1.0-1.7-1.5-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.20.00.30.00.00.5-0.2-0.2-0.3-0.4-0.30.1-0.3-0.10.2
Pavlov. Cond. lever-magazine prob. diff.1.11.42.21.40.9-1.21.20.91.5-1.21.41.11.20.91.51.30.4
Pavlov. Cond. response bias0.30.41.60.60.2-0.30.30.21.0-0.40.70.30.30.11.10.61.3
Time in closed arm before self-admin1.51.72.9-1.2-1.31.1-1.2-1.2-1.71.3-1.4-1.1-1.5-1.0-1.7-1.3-0.9
Time in closed arm after self-admin2.02.12.7-1.3-1.51.4-1.4-1.4-1.61.4-1.6-1.6-1.6-1.3-1.6-1.50.6
Time in open arm before self-admin2.32.54.61.61.4-1.41.41.52.1-1.51.71.41.91.12.11.71.0
Time in open arm after self-admin1.41.52.31.31.5-1.31.31.11.0-1.11.31.51.41.21.01.1-0.9
Bone: periosteal estimation1.32.74.52.02.1-1.71.71.91.7-1.91.51.21.41.41.61.31.0
Bone: periosteal perimeter0.20.31.6-0.3-0.30.5-0.5-0.4-0.20.3-0.4-0.6-0.4-0.7-0.2-0.71.3
Bone: post-yield work6.38.610.93.23.0-3.23.13.02.5-3.02.93.33.13.32.32.6-2.2
Progressive ratio test 1 active lever presses1.31.31.8-1.3-1.31.2-1.3-1.2-1.11.3-1.0-0.8-1.2-1.1-1.0-1.2-0.8
Progressive ratio test 1 breakpoint1.31.41.9-1.4-1.41.3-1.3-1.3-1.11.3-1.0-0.9-1.1-1.1-1.0-1.2-0.5
Progressive ratio test 1 inactive lever presses2.12.33.2-1.7-1.51.7-1.7-1.6-1.31.6-1.5-1.8-1.4-1.7-1.3-1.50.7
Progressive ratio test 2 active lever presses0.80.93.1-0.8-1.00.7-0.7-0.9-1.10.9-0.7-0.2-0.7-0.6-1.1-0.8-1.7
Progressive ratio test 2 breakpoint1.11.32.5-1.1-1.20.9-1.0-1.2-1.41.2-1.0-0.5-0.9-0.9-1.4-1.1-1.6
Progressive ratio test 2 inactive lever presses1.92.13.5-1.8-1.71.4-1.5-1.6-1.61.7-1.1-0.9-1.2-1.4-1.3-1.2-1.9
Incentive Sensitization - Responses0.10.11.10.2-0.0-0.30.20.0-0.20.00.10.40.30.2-0.20.1-1.0
Incentive Sensitization - Breakpoint0.20.21.60.30.1-0.40.30.1-0.1-0.10.20.60.40.3-0.10.2-1.3
Sum of active levers in priming session hrs 5-61.81.83.61.11.1-1.21.21.21.8-1.21.81.21.10.81.91.4-1.0
Progressive ratio0.30.31.90.30.6-0.20.30.30.7-0.60.20.10.60.30.60.51.4
Food seeking constrained by brief footshock1.92.43.81.81.7-1.81.71.51.1-1.51.31.81.71.91.01.4-0.6
Seeking ratio, punishment vs. effort0.50.62.70.80.5-1.00.80.70.2-0.50.71.00.40.90.10.5-1.6
Retroperitoneal fat weight1.86.08.72.92.8-2.82.72.62.3-2.82.32.42.32.72.12.10.3
Reaction time number correct3.24.66.6-2.0-2.32.1-2.1-2.2-2.52.1-2.5-2.2-2.2-1.8-2.6-2.10.7
Reaction time mean minus median10.413.716.73.63.7-3.73.83.84.0-3.64.14.03.93.64.03.9-1.2
Reaction time mean minus median AUC8.210.712.83.43.4-3.53.43.33.2-3.33.43.63.43.43.23.5-1.1
Reaction time num false alarms0.60.82.00.61.4-0.50.71.11.0-1.00.70.60.90.81.00.71.1
Reaction time num false alarms AUC0.30.42.30.21.0-0.10.30.70.5-0.60.10.10.40.60.40.31.5
Reaction time trials correct on left3.24.66.6-2.0-2.32.1-2.1-2.2-2.52.1-2.5-2.2-2.2-1.8-2.6-2.10.7
Reaction time trials on left2.73.95.6-1.8-2.12.0-2.0-2.0-2.31.9-2.3-2.1-2.1-1.7-2.4-1.90.7
Reaction time mean9.413.116.83.53.4-3.63.63.63.9-3.64.04.13.73.74.03.9-1.1
Reaction time mean AUC10.113.517.43.53.6-3.63.73.84.1-3.84.03.93.73.64.24.0-0.5
Median of all reaction times6.38.711.52.82.7-2.92.92.93.2-3.03.23.42.93.23.23.2-0.8
Reaction time omissions16.422.330.74.45.1-4.54.75.15.5-5.05.24.64.84.45.54.8-0.8
Reaction time false alarm rate1.31.73.31.11.8-1.11.21.51.5-1.41.31.11.31.31.61.20.9
Reaction time premature initiation rate3.95.28.3-2.9-2.22.7-2.5-2.3-1.62.2-2.0-2.7-2.2-2.8-1.3-1.91.7
Reaction time premature initiations6.69.312.6-3.5-3.03.4-3.3-3.1-2.73.0-3.1-3.6-3.1-3.4-2.5-2.72.0
Std. dev. reaction times13.018.322.04.24.3-4.34.34.44.5-4.24.74.74.44.34.54.5-1.4
Reaction time trials completed2.73.95.6-1.8-2.12.0-2.0-2.0-2.31.9-2.3-2.1-2.1-1.7-2.4-1.90.7
Reaction time trials AUC2.84.05.6-1.9-2.12.0-2.0-2.0-2.32.0-2.4-2.1-2.1-1.7-2.4-2.00.8
Run reversals in cocaine runway, females1.61.52.6-1.0-1.51.3-1.3-1.3-1.11.1-1.4-1.0-1.2-1.1-1.2-1.21.6
Run reversals in cocaine runway, males0.10.10.40.40.3-0.30.20.30.4-0.20.30.20.30.10.40.30.6
Latency to leave start box in cocaine runway0.10.10.5-0.3-0.30.2-0.1-0.20.5-0.00.40.20.0-0.30.70.1-0.4
Latency to leave start box in cocaine runway, F0.30.30.5-0.7-0.60.6-0.6-0.6-0.40.4-0.3-0.4-0.5-0.7-0.2-0.6-0.5
Latency to leave start box in cocaine runway, M0.70.72.00.50.5-0.60.60.61.2-0.81.10.80.80.61.40.90.0
Std. dev. time between licks in bursts1.62.04.81.22.2-1.31.31.21.0-1.11.41.51.21.41.10.9-2.2
Total sessions with >9 infusions0.50.55.1-0.7-0.80.3-0.4-0.6-0.20.50.30.4-0.4-0.20.0-0.2-2.3
Short access day 1 total inactive lever presses2.42.73.6-1.6-1.61.6-1.6-1.8-1.91.6-1.8-1.6-1.8-1.6-1.9-1.80.1
Short access day 10 total inactive lever presses0.50.62.7-0.6-0.50.7-0.6-0.6-0.20.4-0.6-1.1-0.9-0.9-0.2-0.41.6
Short access day 1 total infusions1.11.24.8-1.1-1.20.8-0.9-1.1-1.11.2-0.5-0.5-1.2-0.9-0.9-0.9-2.2
Short access day 10 total infusions0.60.63.4-0.9-0.90.6-0.7-0.8-0.70.8-0.3-0.1-0.4-0.6-0.5-0.5-1.8
Short access total infusions1.92.25.9-1.5-1.71.2-1.3-1.5-1.61.6-0.9-0.6-1.4-1.2-1.4-1.4-2.4
Short access day 1 locomotion0.10.10.50.1-0.00.1-0.1-0.1-0.20.1-0.3-0.3-0.2-0.0-0.30.00.7
Short access day 10 total locomotion3.13.44.82.22.0-2.12.11.91.7-2.01.71.71.82.01.51.9-0.5
Short access total locomotion0.20.20.70.50.2-0.50.40.20.1-0.30.30.60.30.60.00.4-0.8
One hour access (0.3 mA shock)1.61.93.2-1.3-1.41.3-1.4-1.5-1.81.5-1.5-1.0-1.2-1.3-1.8-1.4-0.4
Compulsive drug intake0.40.41.21.10.8-0.80.70.70.2-0.50.20.60.70.90.00.50.7
One hour access (shock baseline)2.52.94.1-2.0-1.81.8-1.8-1.9-1.91.8-1.6-1.3-1.5-1.8-1.7-1.6-1.1
Social response proportion0.40.50.80.50.8-0.70.80.70.3-0.90.50.80.70.90.30.6-0.7
Social responses0.10.10.50.20.1-0.10.0-0.0-0.3-0.0-0.5-0.6-0.0-0.2-0.6-0.10.7
Social time0.60.81.2-1.1-0.90.9-0.8-0.8-0.90.6-0.8-0.9-1.0-0.9-0.8-1.1-0.9
Soleus weight0.10.31.80.30.10.0-0.10.1-0.30.2-0.5-0.7-0.5-0.3-0.5-0.51.4
Bone: stiffness0.00.10.20.50.3-0.30.2-0.1-0.0-0.10.10.10.30.1-0.10.00.3
Tibialis anterior weight1.24.08.42.92.2-2.42.32.11.8-2.11.81.62.11.81.51.90.4
Time to tail flick, vehicle, before self-admin1.21.25.21.11.2-0.80.91.21.1-1.00.60.20.90.90.91.02.3
Time to tail flick, vehicle, after self-admin0.10.10.7-0.2-0.10.0-0.00.1-0.30.1-0.10.3-0.10.4-0.3-0.0-0.8
Time to tail flick, test, before self-admin1.91.82.71.21.4-1.31.41.31.6-1.31.61.21.41.31.61.5-0.4
Time to tail flick, test, after self-admin0.20.20.90.20.3-0.00.00.2-0.50.0-0.50.0-0.20.3-0.7-0.30.9
Delta time to tail flick, vehicle, before/after SA2.22.25.8-1.6-1.51.2-1.3-1.3-1.91.5-1.3-0.4-1.3-0.8-1.8-1.5-2.4
Delta time to tail flick, test, before/after SA1.21.12.3-0.7-0.70.9-0.9-0.8-1.40.9-1.4-0.8-1.2-0.7-1.5-1.31.0
Tibia length0.00.10.60.30.1-0.40.30.1-0.1-0.10.10.60.10.7-0.20.0-0.8
Ambulatory time before self-admin0.20.21.40.50.2-0.50.40.30.2-0.20.60.60.10.20.30.3-1.2
Ambulatory time after self-admin0.10.10.5-0.0-0.30.0-0.1-0.3-0.10.20.1-0.2-0.5-0.40.0-0.1-0.7
Bone: tissue strength0.90.81.8-1.3-1.01.2-1.1-1.0-0.31.0-0.4-0.8-1.0-1.4-0.0-0.70.4
Total heroin consumption1.82.26.91.21.6-0.91.11.42.1-1.51.20.11.30.62.01.32.6
Bone: trabecular number0.81.23.0-0.9-1.01.1-1.0-0.9-1.00.9-1.4-1.3-0.8-0.8-1.2-1.11.7
Bone: trabecular spacing0.30.41.5-0.7-0.60.5-0.6-0.7-0.60.7-0.20.0-0.7-0.5-0.4-0.7-1.2
Bone: trabecular thickness0.10.10.3-0.1-0.10.1-0.1-0.1-0.40.2-0.5-0.30.10.0-0.5-0.30.1
Bone: trabecular tissue density0.10.10.40.10.6-0.10.10.2-0.4-0.0-0.2-0.0-0.10.4-0.5-0.3-0.3
Water consumed over 24 hours3.03.65.72.41.1-2.32.32.31.9-2.21.91.72.01.71.71.60.4
Number of responses in last shaping day0.00.00.3-0.2-0.00.2-0.2-0.1-0.10.2-0.2-0.3-0.0-0.2-0.1-0.00.5