C2h4orf17

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr2_229380762_229383931	0.02	0.01	4.2e-03	0.01	0.02	0.02	0.01	1.5e-02	6.2e-04	1.2e-03	2.1e-03
2	NAcc	intron excision ratio	chr2_229372719_229373788	0.04	0.02	2.5e-05	0.04	0.03	0.03	0.03	2.9e-06	2.4e-05	9.6e-05	1.3e-05
3	IC	intron excision ratio	chr2_229373931_229380698	0.11	0.07	6.7e-03	0.06	0.02	0.05	0.04	1.6e-03	4.2e-02	4.9e-03	8.4e-03
4	NAcc	intron excision ratio	chr2_229372719_229380698	0.18	0.09	0.0e+00	0.15	0.16	0.17	0.15	9.4e-22	1.4e-23	1.1e-25	1.1e-22
5	BLA	gene expression	C2h4orf17	0.12	0.07	2.1e-04	0.07	0.05	0.05	0.06	8.9e-05	9.8e-04	1.0e-03	2.8e-04
6	NAcc	gene expression	C2h4orf17	0.12	0.08	3.4e-07	0.04	0.05	0.05	0.04	1.2e-06	2.7e-08	3.7e-08	2.3e-07
7	IC	intron excision ratio	chr2_229372719_229380698	0.12	0.07	4.7e-03	0	0.04	0.05	0.03	3.0e-01	8.7e-03	5.2e-03	2.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.7	1.2	2.8	1.7	-1.1	0.6	1.2	1.5	-0.1	0.6
Area under the delay curve	0.0	0.0	0.1	0.2	-0.4	-0.2	0.0	0.2	-0.1	0.1
BMI with tail	0.5	1.8	3.8	-1.9	1.2	0.3	-1.8	-1.4	-1.1	-0.8
BMI without tail	1.2	3.6	6.3	-1.7	1.7	1.5	-2.5	-1.8	-2.3	-1.5
Body weight	0.8	3.7	7.3	-2.7	2.0	0.6	-2.4	-2.1	-1.6	-1.2
Weight adjusted by age	0.2	0.3	1.5	-0.6	-0.2	0.1	0.3	0.2	-0.0	-1.2
Bone surface	0.4	0.7	1.8	1.4	-0.6	0.7	0.8	1.0	-0.6	0.4
Bone volume	0.4	0.7	1.7	1.2	-0.2	1.3	0.5	0.5	-0.8	-0.1
Breakpoint value in progressive ratio session	0.6	0.7	1.5	-0.2	-0.9	-1.2	0.3	1.1	1.0	0.6
Number of licking bursts	1.0	1.7	5.1	-1.3	-0.4	-2.3	-0.0	0.3	1.8	1.2
Context. condit. distance diff. score	1.6	1.9	3.3	0.3	-1.4	-1.7	1.1	1.3	1.8	1.3
Locomotion velocity, session 1	1.8	1.9	4.3	-2.1	1.9	-0.1	-1.4	-1.3	-0.8	-1.2
Locomotion distance, session 1	1.6	2.0	6.8	-2.6	1.2	-1.6	-1.2	-1.0	0.9	-0.5
Locomotion velocity, session 2	0.1	0.1	0.4	-0.6	0.1	-0.1	0.0	0.3	-0.0	-0.3
Locomotion distance, session 2	2.0	2.8	8.3	-2.9	1.6	-1.4	-1.7	-1.4	0.5	-1.1
Locomotion velocity, session 3	1.6	1.8	3.7	-1.9	1.7	-1.0	-1.9	-1.3	0.3	-0.0
Locomotion distance, session 3	0.3	0.3	0.8	-0.6	0.1	-0.9	-0.7	-0.0	0.7	0.4
Stereotopy head waving bouts, day 3	1.4	1.7	2.9	-1.3	1.7	0.6	-1.7	-1.5	-0.7	-1.1
Stereotopy head waving duration, day 3	1.2	1.4	2.6	-1.5	1.6	0.3	-1.4	-1.5	-0.4	-0.8
Locomotion velocity, session 7	0.7	0.8	2.4	-1.6	0.5	-0.9	-1.0	-0.6	0.4	-0.6
Locomotion distance, session 7	1.2	1.6	4.9	-1.2	-0.8	-2.2	-0.2	0.5	1.8	0.6
Stereotopy head waving bouts, day 7	2.1	2.4	4.2	-0.4	2.1	1.4	-1.6	-1.8	-1.3	-1.6
Stereotopy head waving duration, day 7	2.2	2.6	5.2	-0.6	2.3	1.2	-1.6	-2.2	-1.1	-1.6
Locomotion velocity, session 8	0.2	0.2	0.4	-0.7	0.1	-0.6	-0.7	-0.1	0.4	-0.4
Locomotion distance, session 8	1.7	2.5	7.1	-2.5	0.2	-2.7	-0.6	-0.0	1.9	0.2
Degree of sensitization distance	0.8	0.8	1.5	-0.1	-1.2	-1.0	0.9	1.0	1.0	0.4
Degree of sensitization stereotypy	1.9	2.1	3.2	0.1	1.7	1.8	-1.3	-1.4	-1.6	-1.5
Conditioned locomotion	1.6	1.9	6.0	1.3	0.6	2.5	-0.3	-0.4	-1.8	-1.2
Cocaine response after cond. corrected	0.3	0.4	1.0	0.3	0.4	1.0	-0.4	-0.1	-1.0	-0.6
Cocaine response after cond. not corrected	0.6	0.7	1.9	0.9	-0.1	1.3	-0.2	0.3	-1.4	-0.7
Cocaine response before conditioning	0.1	0.1	0.2	0.2	-0.3	0.2	-0.1	0.2	-0.5	-0.1
Saline control response	1.1	1.5	3.7	-1.2	1.6	0.2	-1.3	-1.9	-0.2	-1.0
Bone: connectivity density	1.9	2.9	5.4	1.9	-2.0	-0.7	2.0	2.3	0.9	1.6
Bone: cortical apparent density	0.1	0.1	0.4	-0.6	0.1	-0.1	0.1	-0.0	0.4	-0.4
Bone: cortical area	0.4	0.5	1.3	-0.3	0.6	1.1	-0.8	-0.6	-1.0	-0.4
Bone: cortical porosity	1.0	1.1	1.9	-1.1	1.4	0.6	-1.2	-1.1	-0.9	-1.0
Bone: cortical porosity	1.6	1.7	2.7	-1.3	1.6	0.8	-1.4	-1.4	-1.2	-1.2
Bone: cortical thickness	0.2	0.3	1.0	-0.2	0.2	1.0	-0.5	-0.0	-0.8	-0.1
Bone: cortical thickness	1.0	1.2	3.8	0.0	0.5	1.7	-0.5	-0.5	-1.9	-0.9
Bone: cortical tissue density	0.1	0.1	0.5	-0.7	0.1	-0.2	0.1	-0.0	0.4	-0.4
Condit. Reinf. active minus inactive responses	1.7	1.9	6.1	-2.5	1.1	-1.2	-1.5	-1.2	0.7	-0.6
Condit. Reinf. active-inactive response ratio	2.5	2.6	9.5	-3.1	1.4	-1.3	-1.6	-1.5	0.5	-0.5
Condit. Reinf. active responses	0.9	1.2	2.9	-1.7	1.0	-0.7	-1.4	-1.1	0.4	-0.7
Condit. Reinf. inactive responses	0.4	0.4	1.3	1.0	0.2	1.2	-0.1	-0.3	-0.6	-0.5
Incentive salience index mean	0.8	1.0	3.0	-1.7	0.8	-0.6	-1.5	-0.9	0.4	-0.3
Condit. Reinf. lever presses	0.1	0.2	0.7	-0.1	0.2	0.2	-0.8	-0.4	0.2	0.3
Condit. Reinf. active minus inactive responses	0.2	0.3	1.3	0.7	-0.0	1.1	0.3	-0.1	-0.6	-0.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.4	-0.4	0.1	0.4	0.3	0.3	0.6
Condit. Reinf. active responses	0.4	0.6	2.3	0.4	0.1	1.5	0.2	-0.1	-1.1	-0.6
Condit. Reinf. inactive responses	0.5	0.7	1.3	-0.6	0.7	1.0	-0.4	-0.6	-1.1	-1.0
Condit. Reinf. lever presses	0.2	0.3	1.1	0.5	-0.5	1.0	-0.0	0.1	-0.8	-0.2
Condit. Reinf. lever reinforcers received	0.4	0.6	2.2	0.5	-0.0	1.5	0.3	-0.1	-1.1	-0.6
Conditioned reinforcement - actives	0.7	1.1	2.6	-1.0	1.0	-1.2	-0.8	-1.0	1.6	0.1
Conditioned reinforcement - inactives	0.2	0.2	0.8	0.0	0.2	0.1	-0.7	-0.5	0.4	-0.9
Conditioned locomotion	1.3	1.7	2.9	1.6	-1.1	-0.9	1.4	1.1	1.7	1.3
Patch foraging indifference point 0 sec	1.1	2.1	3.8	0.5	-1.4	-1.7	1.5	1.3	1.9	1.3
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.0	-0.4	-0.1	0.1	-0.1	0.4	0.1
Delay disc. indifference point, 0s delay	0.7	0.8	1.6	1.3	-0.9	-0.4	0.5	0.9	0.9	1.0
Delay disc. indifference point, 16s delay	0.3	0.3	1.4	-0.6	-0.1	-1.2	-0.2	0.1	0.5	0.5
Delay disc. indifference point, 2s delay	0.7	0.8	2.7	1.6	-0.5	0.5	1.3	0.4	-0.1	0.5
Delay disc. indifference point, 24s delay	0.4	0.4	1.0	1.0	-0.7	0.8	0.0	0.8	-0.4	0.0
Delay disc. indifference point, 4s delay	0.3	0.3	0.8	0.5	-0.9	0.1	0.6	0.7	-0.2	-0.0
Delay disc. indifference point, 8s delay	0.8	0.9	1.8	-1.1	0.9	0.1	-1.3	-1.2	-0.7	-0.8
Indifference point function ln k	0.4	0.7	2.2	-1.5	0.5	-1.3	-0.7	-0.5	0.5	0.1
Indifference point function log k	0.4	0.7	2.2	-1.5	0.5	-1.3	-0.7	-0.5	0.5	0.1
Patch foraging total patch changes 0 sec	1.1	2.0	3.6	0.3	-1.4	-1.8	1.3	1.2	1.9	1.4
Patch foraging total patch changes 12 sec	0.5	0.6	1.1	0.1	-1.0	-0.7	0.9	0.9	0.9	0.5
Patch foraging total patch changes 18 sec	1.0	1.6	3.9	-0.1	-1.2	-1.7	0.8	1.0	2.0	1.1
Patch foraging total patch changes 24 sec	0.2	0.4	0.9	-0.8	0.4	-0.8	-0.6	-0.2	1.0	0.1
Patch foraging total patch changes 6 sec	2.4	3.6	5.3	0.9	-2.3	-1.7	2.1	2.1	2.0	1.8
Patch foraging time to switch 0 sec	0.1	0.2	0.7	0.8	0.0	0.7	0.1	0.2	-0.2	-0.1
Patch foraging water rate 0 sec	0.1	0.2	0.6	-0.3	-0.3	-0.8	0.4	0.4	0.5	0.6
Patch foraging water rate 12 sec	0.8	1.7	3.4	-1.8	1.5	-0.3	-1.8	-1.5	-0.6	-0.4
Patch foraging water rate 18 sec	0.3	0.4	1.3	-0.4	-0.4	-0.9	0.4	0.5	0.1	1.2
Patch foraging water rate 24 sec	0.9	1.2	4.0	-1.3	-0.1	-2.0	-0.7	-0.0	1.0	1.2
Patch foraging water rate 6 sec	1.8	2.6	9.8	-3.1	1.2	-1.0	-1.9	-1.3	-0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	1.5	1.9	4.5	2.1	-1.5	1.0	1.8	1.5	-0.3	-0.2
Distance traveled before self-admin	0.1	0.2	0.5	0.5	0.3	0.5	-0.7	-0.3	0.0	0.1
Distance traveled after self-admin	0.2	0.2	0.8	-0.2	-0.1	-0.9	0.1	0.0	0.9	0.1
Extensor digitorum longus weight	4.0	15.7	20.7	-3.2	4.5	3.4	-4.2	-4.3	-4.3	-3.3
Bone: elastic displacement	0.4	0.4	1.3	-0.5	0.7	0.3	-1.1	-0.8	-0.6	-0.0
Bone: elastic work	0.4	0.6	1.2	-0.7	0.7	0.5	-1.1	-0.7	-1.0	-0.1
Bone: endosteal estimation	0.1	0.1	0.3	-0.2	0.3	0.2	-0.6	-0.5	-0.4	-0.1
Bone: endosteal perimeter	0.3	0.7	1.8	-0.6	1.0	0.2	-1.1	-1.4	-0.3	-0.3
Epididymis fat weight	0.2	0.8	1.8	-1.3	0.9	-0.6	-1.0	-1.1	-0.1	0.1
Delta time in closed arm before/after self-admin	0.9	0.8	1.9	-1.4	1.1	-0.6	-1.0	-1.1	-0.0	-0.2
Delta time in open arm before/after self-admin	1.0	1.0	2.7	-0.5	1.6	0.7	-0.9	-1.5	-0.5	-0.8
Diff in mean of infusions in LGA sessions	1.7	2.0	4.7	0.4	-1.9	-1.6	0.9	2.2	1.1	1.2
Delay discount exponential model param	0.0	0.1	0.2	-0.2	0.4	0.0	-0.1	-0.3	0.3	-0.0
Extinction: sum of active levers before priming	0.3	0.3	0.6	0.1	-0.6	0.7	0.5	0.8	-0.6	-0.3
Active lever presses in extinction session 6	2.9	2.9	4.5	0.6	-1.6	-2.1	1.9	1.7	2.1	1.4
Bone: final force	0.0	0.0	0.2	-0.4	0.1	-0.1	-0.1	-0.2	0.2	0.0
Bone: final moment	0.0	0.0	0.1	-0.3	-0.0	-0.0	0.0	-0.1	-0.0	0.1
Food consumed during 24 hour testing period	0.7	1.0	2.8	-1.7	1.0	0.3	-0.6	-0.5	-1.0	-1.2
Glucose	0.3	0.5	1.5	-1.2	0.1	0.2	-1.1	-0.3	-0.4	-0.8
Heart weight	0.6	0.9	1.6	-0.5	1.1	1.0	-0.8	-1.2	-1.3	-0.6
Delay discount hyperbolic model param	0.1	0.1	0.2	-0.4	0.5	-0.0	-0.3	-0.3	0.2	-0.1
Intermittent access intake day 1-15 change	0.1	0.2	0.8	0.9	-0.7	-0.0	0.2	0.2	0.0	0.2
Intermittent access intake escalation	0.4	0.8	2.1	1.4	-1.3	-0.2	0.8	0.9	0.4	0.7
Intermittent access intake escalation 2	0.7	0.8	1.9	1.4	-1.3	-0.0	1.0	0.9	0.2	0.6
Intermitt. access day 1 inactive lever presses	0.1	0.4	0.9	-1.0	0.4	0.1	-0.5	-0.3	-0.5	-0.9
Intermitt. access day 15 inactive lever presses	0.6	1.2	1.8	-0.8	1.0	1.0	-1.2	-1.1	-1.2	-1.3
Intermitt. access escalation Index	0.6	0.9	2.0	0.1	0.9	1.4	-0.4	-1.0	-1.3	-0.6
Intermittent access day 1 total infusions	0.7	1.2	2.9	-1.7	1.0	0.2	-1.2	-1.0	-0.4	-1.2
Intermittent access day 15 total infusions	0.0	0.1	0.1	-0.3	-0.4	-0.2	0.2	0.1	0.1	-0.3
Intermittent access terminal intake (last 3 days)	0.2	0.3	1.1	-1.1	-0.0	-0.8	-0.1	-0.2	0.4	-0.3
Intermittent access total infusions	0.5	0.6	2.4	-1.5	0.4	-0.6	-0.8	-0.6	0.2	-0.6
Intermittent access day 1 locomotion	0.2	0.3	1.1	-1.0	0.4	-0.3	-0.5	-0.5	0.2	-0.3
Intermittent access day 15 total locomotion	0.4	0.7	1.3	0.9	-1.1	-0.6	0.4	0.9	0.9	0.9
Intermittent access total locomotion	0.1	0.1	0.2	0.1	-0.5	-0.2	0.0	0.3	0.4	-0.1
Intermittent access standard deviation	0.0	0.1	0.4	0.0	-0.3	-0.6	-0.1	-0.0	0.2	0.3
Left kidney weight	0.4	2.1	3.0	-1.7	1.5	1.1	-1.7	-1.3	-1.4	-1.2
Right kidney weight	0.4	1.8	2.4	-1.5	1.5	0.9	-1.3	-1.5	-1.3	-1.2
Cocaine induced anxiety	0.4	0.6	1.5	0.3	-0.5	-1.1	0.5	0.7	0.8	1.2
Post-drug Anxiety	0.8	0.8	1.7	0.8	-0.7	-0.9	0.9	0.8	0.7	1.3
Baseline Anxiety	0.2	0.2	0.4	-0.3	0.3	0.5	-0.1	-0.5	-0.7	-0.4
Tail length	0.2	0.9	1.5	-0.2	1.1	1.2	-1.0	-0.9	-1.2	-0.6
Length with tail	0.3	1.1	1.6	-1.2	1.3	0.5	-1.1	-1.3	-1.1	-0.7
Length without tail	0.1	0.3	0.9	-0.8	0.4	-0.9	0.1	-0.3	0.4	0.6
Times rat made contact with spout	0.3	0.4	1.5	0.2	-0.9	0.1	0.6	1.2	-0.2	-0.1
Lifetime Intake	0.7	0.9	2.9	-1.7	0.7	-0.7	-1.0	-0.8	0.3	-0.7
Liver weight, left	0.2	0.3	0.8	-0.5	0.2	-0.8	-0.0	-0.2	0.9	0.5
Liver weight, right	0.4	0.7	2.0	-0.2	-0.4	-1.0	0.7	0.2	1.4	1.0
Locomotor activity	0.1	0.1	0.3	-0.1	-0.5	0.0	0.4	0.2	-0.1	-0.4
Locomotor testing distance	0.2	0.4	1.0	-0.5	0.0	0.5	0.0	-0.1	-1.0	-1.0
Locomotor testing rearing	0.3	0.6	1.3	-0.7	-1.2	-0.1	0.6	1.0	-0.6	-0.6
Locomotion in novel chamber	4.9	6.3	12.5	3.5	-2.9	0.2	3.5	3.0	1.0	1.0
Locomotion in novel chamber post-restriction	0.6	0.9	2.7	0.3	0.1	1.5	-0.3	0.0	-1.0	-1.6
Fecal boli incidents, locomotor time 1	0.5	0.7	2.7	-0.5	0.7	0.8	-0.5	-0.7	0.1	-1.6
Change in fecal boli incidents, locomotor task	0.3	0.3	1.0	-0.4	-0.3	0.1	-1.0	-0.0	-0.6	-0.5
Time >=10cm from walls, locomotor time 1	2.4	2.6	4.4	1.3	-2.1	-1.1	1.5	1.8	1.6	1.6
Bouts of movement, locomotor time 1	0.5	0.5	1.1	0.7	-0.9	0.1	1.0	0.9	0.1	0.7
Total resting periods, locomotor time 1	0.2	0.2	0.6	0.3	-0.6	-0.0	0.8	0.5	0.1	0.4
Rest time, locomotor task time 1	0.5	0.7	1.6	0.2	0.9	0.9	-0.3	-0.8	-1.3	-0.8
Distance moved, locomotor task time 1	0.2	0.2	0.6	-0.4	-0.4	-0.7	0.0	0.4	0.3	0.6
Vertical activity count, locomotor time 1	0.3	0.6	1.3	0.1	-0.8	-0.8	0.7	0.8	0.9	1.1
Time >=10cm from walls, locomotor time 2	1.1	1.7	4.1	-1.4	1.6	0.3	-2.0	-1.5	-0.7	-0.5
Bouts of movement, locomotor time 2	0.5	0.8	1.6	1.3	-1.0	-0.2	0.3	1.2	0.4	1.2
Total resting periods, locomotor time 2	0.5	0.8	1.8	1.3	-1.0	-0.2	0.5	1.3	0.4	1.1
Rest time, locomotor task time 2	0.7	0.9	1.9	1.4	-0.5	1.3	1.2	0.2	-0.9	-0.6
Distance moved, locomotor task time 2	0.6	0.7	1.8	-0.7	0.5	-1.3	-0.7	-0.3	0.6	1.2
Vertical activity count, locomotor time 2	0.1	0.2	0.7	-0.0	0.2	-0.4	-0.2	0.3	0.3	0.9
Light reinforcement 1	0.4	0.9	4.1	-2.0	0.8	-0.5	-0.9	-0.7	-0.3	-0.5
Light reinforcement 2	0.1	0.2	0.9	-0.1	0.1	0.6	-0.2	-0.2	-0.9	-0.4
Bone: marrow area	0.0	0.1	0.2	-0.1	0.2	0.2	-0.5	-0.4	-0.4	-0.1
Bone: maximum diameter	0.1	0.1	0.4	0.1	0.1	0.7	-0.3	-0.2	-0.4	-0.1
Bone: maximum force	0.1	0.2	0.6	-0.3	0.0	-0.6	-0.1	0.0	0.5	0.7
Bone: maximum moment	0.1	0.1	0.5	-0.1	-0.1	-0.4	0.0	0.1	0.3	0.7
Mean time between licks in bursts	0.5	1.3	2.9	-0.3	-0.8	-1.7	0.8	1.0	1.4	1.4
Mean num. licks in bursts	1.1	1.7	4.8	1.3	-0.2	2.2	0.2	0.4	-1.9	-1.2
Cd content in liver	0.4	0.4	1.0	-0.4	-0.2	-1.0	0.6	0.2	0.9	0.7
Co content in liver	3.3	3.9	8.8	-3.0	2.0	-0.8	-2.6	-2.4	-0.1	-1.1
Cu content in liver	2.8	3.3	4.9	1.1	-1.9	-1.7	2.2	2.0	1.7	1.9
Fe content in liver	0.5	0.6	2.8	1.7	0.2	0.9	0.6	-0.0	-0.1	0.7
K content in liver	0.7	0.7	1.7	1.3	-1.3	0.1	0.3	1.0	0.7	0.3
Mg content in liver	0.6	0.6	1.4	0.2	-1.0	-0.8	0.4	0.7	1.2	0.5
Mn content in liver	0.3	0.3	0.6	0.6	-0.6	0.8	0.2	0.7	-0.4	-0.4
Na content in liver	0.3	0.3	0.7	0.8	-0.6	0.1	-0.1	0.7	0.1	0.6
Rb content in liver	0.2	0.2	0.5	-0.3	0.5	-0.7	-0.3	-0.3	0.7	0.4
Se content in liver	0.2	0.3	0.8	0.7	0.2	0.9	-0.3	-0.2	-0.5	-0.4
Sr content in liver	0.9	0.8	2.2	0.4	-0.0	1.5	-0.1	-0.4	-1.4	-1.2
Zn content in liver	24.1	26.8	43.1	4.4	-6.6	-3.8	5.4	5.8	4.8	4.9
Bone: minimum diameter	1.1	2.0	3.0	-1.7	1.7	0.5	-1.6	-1.6	-1.2	-0.9
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.2	0.6	-0.2	-0.2	-0.3	0.4	-0.1
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.6	-0.2	0.6	0.4	-0.2	-0.6	0.0
Total zone transitions, hab. session 1	2.4	3.3	7.4	-2.7	2.3	-0.8	-2.1	-1.9	0.2	-1.2
Total locomotion distance, hab. session 1	0.4	0.6	1.3	-1.1	0.6	-1.1	-0.8	-0.5	0.8	0.1
Locomotion velocity, hab. session 1	0.4	0.5	1.3	-1.1	0.3	-1.0	-0.8	-0.3	0.7	0.0
Time in familiar zone, hab. session 2	1.2	1.2	4.2	1.0	-0.3	2.1	0.4	0.2	-1.5	-1.0
Time in novel zone, hab. session 2	0.7	0.7	2.2	-0.6	-0.1	-1.5	0.1	0.1	1.4	0.6
Total zone transitions, hab. session 2	1.3	1.7	5.0	-2.2	1.4	-1.2	-1.3	-1.1	0.7	-0.4
Total locomotion distance, hab. session 2	0.2	0.3	1.1	-1.1	0.2	-0.5	-0.5	-0.2	0.2	-0.1
Locomotion velocity, hab. session 2	0.2	0.2	0.9	-0.9	0.1	-0.7	-0.4	-0.0	0.4	0.0
Novel to familiar place preference ratio	0.1	0.2	0.5	-0.5	-0.3	-0.4	0.7	0.2	0.1	-0.3
Novelty place preference	0.2	0.2	0.6	-0.5	-0.4	-0.4	0.8	0.3	-0.1	-0.4
Time in novel zone, NPP test	0.2	0.2	0.6	-0.4	-0.4	-0.2	0.8	0.3	-0.2	-0.4
Total zone transitions, NPP test	1.3	1.8	6.2	-2.5	1.4	-0.8	-1.5	-1.0	0.3	-0.7
Total locomotion distance, NPP test	0.3	0.4	1.0	-0.8	-0.3	-1.0	-0.1	0.3	0.8	0.6
Locomotion velocity, NPP test	0.3	0.4	0.9	-0.9	-0.3	-0.9	-0.1	0.4	0.7	0.5
Intraocular pressure	0.2	0.3	0.9	0.7	0.3	0.9	0.0	-0.4	-0.7	0.2
Delta distance traveled before/after self-admin	0.6	0.6	2.4	-1.0	-0.2	-1.5	0.5	0.0	0.9	0.3
Delta ambulatory time before/after self-admin	0.5	0.7	2.4	-0.8	-0.4	-1.6	0.4	0.4	0.9	0.5
Parametrial fat weight	0.4	0.9	2.3	0.7	-1.1	-1.1	0.8	0.4	0.9	1.5
Pavlov. Cond. lever latency	0.6	0.8	1.1	-1.0	1.0	0.4	-0.7	-1.0	-0.9	-1.0
Pavlov. Cond. magazine entry latency	0.3	0.4	1.0	-0.4	0.8	0.2	-1.0	-0.9	-0.2	-0.4
Pavlov. Cond. change in total contacts	0.3	0.3	1.1	-0.4	-0.1	-0.7	-0.4	0.1	1.0	0.1
Pavlov. Cond. index score	0.2	0.2	0.4	0.7	-0.6	-0.0	0.1	0.5	0.4	0.5
Pavlov. Cond. latency score	0.3	0.4	0.8	0.9	-0.8	-0.2	0.4	0.8	0.6	0.7
Pavlov. Cond. lever contacts	0.5	0.6	1.0	0.9	-0.9	-0.3	0.4	0.9	0.8	1.0
Pavlov. Cond. magazine entry number	0.4	0.6	1.1	1.0	-1.0	0.1	1.1	0.8	0.0	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.8	0.4	-0.6	-0.8	0.5	0.1	0.9	0.9
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.6	-0.7	-0.0	0.2	0.6	0.3	0.3
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.3	0.4	-0.5	-0.6	-0.4	0.6	0.4
Pavlov. Cond. lever latency	0.4	0.5	1.2	1.0	-0.6	0.3	1.1	0.9	0.2	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.2	0.5	-0.1	0.4	-0.3	-0.4	-0.1	0.1
Pavlov. Cond. change in total contacts	0.1	0.2	0.6	0.0	-0.5	-0.5	0.3	0.2	0.3	0.7
Pavlov. Cond. index score	0.1	0.1	0.3	0.6	-0.2	0.3	-0.2	-0.2	-0.2	0.6
Pavlov. Cond. latency score	0.2	0.2	0.7	0.7	-0.5	-0.1	0.1	0.2	0.3	0.9
Pavlov. Cond. lever contacts	0.4	0.5	1.1	-0.8	0.7	0.1	-1.0	-1.1	-0.5	0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.6	0.1	-0.4	0.2	0.1	0.1	-0.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	0.9	0.4	-0.3	0.9	0.8	0.6	-0.9	-0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.4	0.7	-0.3	0.3	-0.1	-0.1	-0.1	0.6
Pavlov. Cond. response bias	0.8	1.1	2.2	-0.8	1.1	0.6	-1.4	-1.5	-0.9	-0.4
Time in closed arm before self-admin	0.6	0.8	2.1	-0.0	-0.6	-1.4	0.0	0.5	1.5	0.8
Time in closed arm after self-admin	1.9	2.0	4.6	0.1	-1.2	-2.2	0.8	1.2	1.8	1.6
Time in open arm before self-admin	0.6	0.6	1.7	0.0	-0.4	1.2	0.6	0.3	-1.3	-0.7
Time in open arm after self-admin	1.0	1.1	2.1	-0.3	1.2	1.5	-0.2	-1.1	-1.2	-1.0
Bone: periosteal estimation	0.3	0.7	1.2	-0.5	0.7	0.9	-1.0	-0.8	-1.1	-0.5
Bone: periosteal perimeter	0.8	1.4	2.1	-0.7	1.3	1.2	-1.5	-1.4	-1.2	-1.0
Bone: post-yield work	1.2	1.8	3.9	0.6	-0.8	-1.9	0.7	0.6	2.0	1.8
Progressive ratio test 1 active lever presses	2.1	2.6	7.5	-2.7	1.7	-0.4	-1.6	-1.7	-0.7	-1.4
Progressive ratio test 1 breakpoint	1.8	2.2	7.2	-2.7	1.5	-0.6	-1.4	-1.5	-0.5	-1.2
Progressive ratio test 1 inactive lever presses	0.8	1.2	2.3	-0.8	0.6	1.0	-1.4	-0.8	-1.2	-1.5
Progressive ratio test 2 active lever presses	1.6	1.8	3.3	-1.7	1.4	0.5	-1.5	-1.8	-0.9	-1.2
Progressive ratio test 2 breakpoint	1.3	1.5	2.4	-1.5	1.2	0.5	-1.3	-1.6	-0.9	-1.2
Progressive ratio test 2 inactive lever presses	0.5	0.8	1.7	-0.9	1.1	0.4	-0.7	-1.3	-0.3	-1.2
Incentive Sensitization - Responses	0.1	0.1	0.5	0.7	-0.1	0.3	0.1	-0.4	0.4	0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.7	0.8	-0.2	0.5	0.2	-0.3	0.1	0.2
Sum of active levers in priming session hrs 5-6	2.1	1.9	5.0	1.5	-2.0	0.1	1.2	2.2	0.2	0.8
Progressive ratio	1.1	1.7	5.1	0.5	0.5	2.3	0.1	-0.3	-1.8	-1.7
Food seeking constrained by brief footshock	0.1	0.1	0.5	-0.7	0.1	-0.2	-0.1	-0.0	-0.4	0.2
Seeking ratio, punishment vs. effort	0.8	1.1	3.8	-0.9	-0.4	-2.0	-0.1	0.3	1.1	1.3
Retroperitoneal fat weight	0.1	0.4	1.5	-0.3	0.3	0.7	-0.6	-0.7	-1.2	-0.0
Reaction time number correct	0.1	0.2	0.8	-0.3	0.1	0.4	-0.2	-0.0	-0.9	-0.7
Reaction time mean minus median	0.2	0.6	2.1	1.1	0.1	1.4	0.1	-0.3	-0.5	-0.6
Reaction time mean minus median AUC	0.2	0.4	1.3	1.1	-0.1	1.2	0.3	0.1	-0.5	-0.3
Reaction time num false alarms	0.7	1.0	2.7	-0.8	1.7	0.2	-0.6	-1.4	-0.4	-1.1
Reaction time num false alarms AUC	1.2	1.9	4.5	-0.9	2.1	0.6	-1.2	-2.0	-0.7	-1.2
Reaction time trials correct on left	0.1	0.2	0.8	-0.3	0.1	0.4	-0.2	-0.0	-0.9	-0.7
Reaction time trials on left	0.1	0.2	0.9	-0.2	0.0	0.5	-0.2	0.0	-0.9	-0.7
Reaction time mean	0.8	1.3	4.5	0.9	0.2	2.1	-0.2	-0.4	-1.6	-1.2
Reaction time mean AUC	1.0	1.6	5.0	0.6	0.5	2.2	-0.4	-0.6	-1.8	-1.5
Median of all reaction times	1.0	1.4	4.1	0.5	0.4	2.0	-0.4	-0.5	-1.8	-1.3
Reaction time omissions	0.7	1.0	4.0	2.0	-0.2	1.4	0.8	0.2	-0.8	0.1
Reaction time false alarm rate	0.5	0.7	2.2	-0.4	1.5	0.2	-0.5	-1.3	-0.1	-0.6
Reaction time premature initiation rate	1.7	2.3	4.3	-1.5	2.0	0.6	-1.7	-2.1	-0.9	-1.2
Reaction time premature initiations	1.8	3.3	5.0	-1.7	2.2	1.0	-2.0	-2.2	-1.5	-1.7
Std. dev. reaction times	0.4	0.7	2.5	1.6	-0.2	1.4	0.4	0.1	-0.4	-0.2
Reaction time trials completed	0.1	0.2	0.9	-0.2	0.0	0.5	-0.2	0.0	-0.9	-0.7
Reaction time trials AUC	0.1	0.2	0.7	-0.3	0.1	0.3	-0.2	-0.0	-0.8	-0.6
Run reversals in cocaine runway, females	0.2	0.2	0.4	-0.0	-0.6	0.1	0.1	0.6	-0.1	-0.5
Run reversals in cocaine runway, males	0.6	0.6	1.8	-1.0	0.2	0.2	-0.5	0.0	-0.9	-1.4
Latency to leave start box in cocaine runway	0.7	0.8	1.3	0.3	-1.1	-1.1	0.3	1.1	1.0	0.8
Latency to leave start box in cocaine runway, F	0.7	0.8	2.2	-0.2	-0.4	-1.5	-0.2	0.3	1.2	1.2
Latency to leave start box in cocaine runway, M	1.3	1.2	2.9	1.1	-1.7	0.2	1.2	1.7	0.3	-0.2
Std. dev. time between licks in bursts	2.5	3.3	10.8	-1.2	-0.8	-3.3	1.1	1.0	2.4	1.7
Total sessions with >9 infusions	1.4	1.7	4.8	-2.2	0.9	-1.6	-1.2	-0.8	1.2	-0.6
Short access day 1 total inactive lever presses	0.6	0.8	2.0	-1.3	-0.0	-1.4	-0.9	0.2	1.2	-0.1
Short access day 10 total inactive lever presses	0.1	0.3	0.8	0.9	-0.6	-0.1	-0.1	0.6	0.5	0.3
Short access day 1 total infusions	1.1	1.4	3.6	-1.5	0.6	-1.9	-0.8	-0.5	1.7	0.3
Short access day 10 total infusions	1.0	1.2	3.5	-1.9	0.8	-0.5	-1.7	-0.8	0.1	-0.8
Short access total infusions	1.1	1.4	4.4	-2.1	0.8	-1.1	-1.2	-0.8	0.6	-0.8
Short access day 1 locomotion	1.8	2.2	7.0	-1.5	-0.1	-2.6	-0.4	0.2	2.2	1.1
Short access day 10 total locomotion	0.2	0.4	0.8	-0.1	-0.8	-0.8	0.5	0.9	0.8	0.4
Short access total locomotion	0.6	0.7	1.6	-0.4	-0.9	-1.3	0.4	0.9	1.3	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.1	-0.3	0.1	0.2	-0.0	0.0	-0.2
Compulsive drug intake	0.4	0.5	1.4	0.8	-0.5	1.2	0.4	0.3	-0.7	-0.1
One hour access (shock baseline)	0.2	0.3	0.7	-0.7	0.4	-0.0	-0.8	-0.6	-0.3	-0.5
Social response proportion	0.1	0.2	0.5	0.7	-0.1	0.5	0.2	-0.4	0.2	-0.2
Social responses	0.5	0.7	1.3	0.9	-1.0	0.1	1.1	1.1	-0.1	0.5
Social time	1.1	1.5	4.6	2.2	-1.2	0.2	1.7	1.0	0.6	0.8
Soleus weight	1.0	3.1	4.9	-1.4	1.9	1.3	-2.2	-2.1	-1.7	-1.5
Bone: stiffness	0.0	0.1	0.3	-0.6	0.1	-0.1	-0.1	0.0	0.2	0.1
Tibialis anterior weight	4.7	16.1	25.8	-3.1	4.4	3.6	-4.3	-3.8	-5.1	-3.5
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.3	0.3	0.2	0.2	-0.2	-0.3	0.6	-0.4
Time to tail flick, vehicle, after self-admin	0.3	0.4	1.7	1.3	0.2	0.7	0.2	-0.2	-0.0	0.8
Time to tail flick, test, before self-admin	0.5	0.5	1.7	1.3	-0.4	0.7	1.0	0.3	-0.1	-0.3
Time to tail flick, test, after self-admin	0.2	0.2	0.6	0.3	-0.2	-0.5	0.2	0.0	0.7	0.7
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.7	-0.0	0.1	-0.3	0.0	0.1	0.1	0.8
Delta time to tail flick, test, before/after SA	0.5	0.5	1.0	-1.0	0.4	-0.9	-0.9	-0.4	0.4	0.7
Tibia length	0.8	2.1	5.8	-0.1	1.3	2.2	-0.8	-1.0	-2.4	-1.0
Ambulatory time before self-admin	0.1	0.2	0.5	0.4	0.3	0.5	-0.7	-0.3	0.1	-0.2
Ambulatory time after self-admin	0.5	0.6	2.1	0.1	-0.1	-1.3	0.2	0.0	1.5	0.5
Bone: tissue strength	0.6	0.6	1.7	-0.3	-0.2	-1.3	0.4	0.1	0.7	1.2
Total heroin consumption	0.3	0.4	0.8	0.9	-0.7	0.3	0.7	0.8	0.0	0.3
Bone: trabecular number	0.3	0.5	1.8	1.4	-0.4	0.3	0.6	0.7	0.3	0.6
Bone: trabecular spacing	0.3	0.4	1.2	0.4	-1.1	-0.0	0.7	0.8	-0.2	0.4
Bone: trabecular thickness	0.4	0.6	1.3	-0.5	0.9	0.7	-0.7	-0.5	-0.5	-1.1
Bone: trabecular tissue density	0.7	1.0	1.7	-0.8	1.1	0.7	-1.3	-1.0	-0.5	-1.3
Water consumed over 24 hours	0.1	0.2	0.7	-0.8	0.3	0.0	-0.5	-0.0	-0.0	-0.4
Number of responses in last shaping day	2.7	2.9	6.0	-2.1	2.2	-0.1	-2.5	-2.0	-0.3	-1.1