C20h6orf136

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	C20h6orf136	0.06	0.04	4.4e-06	0.03	0.04	0.04	0.04	1.1e-04	1.5e-05	5.3e-05	4.3e-05
2	Brain	isoform ratio	NM_213610.3	0.03	0.03	6.1e-03	0.01	0.02	0	0.01	2.3e-02	5.9e-03	1.9e-01	4.1e-02
3	Brain	mRNA stability	C20h6orf136	0.13	0.07	1.0e-11	0.11	0.13	0.12	0.12	2.9e-10	7.2e-12	5.3e-11	5.1e-11
4	Liver	gene expression	C20h6orf136	0.16	0.08	0.0e+00	0.16	0.16	0.15	0.16	2.1e-17	1.0e-17	2.1e-16	2.1e-17
5	IL	gene expression	C20h6orf136	0.18	0.12	6.2e-03	0.08	0.07	0.04	0.15	4.8e-03	7.7e-03	5.1e-02	2.3e-04
6	IC	isoform ratio	XM_006255918.4	0.07	0.05	8.6e-03	0.08	0.05	0.03	0.06	4.4e-04	4.0e-03	2.2e-02	2.2e-03
7	NAcc	mRNA stability	C20h6orf136	0.01	0.01	8.5e-03	0.01	0.01	0	0.01	1.2e-02	1.6e-02	5.2e-02	2.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.7	1.3	3.1	-1.7	-0.2	-1.1	-0.7	0.7	-1.8	0.9
Area under the delay curve	1.1	1.7	2.3	1.4	1.2	1.5	1.4	-1.0	1.5	-1.2
BMI with tail	1.9	6.5	8.8	1.8	2.8	2.6	2.8	-3.0	2.1	-2.6
BMI without tail	2.1	11.1	12.7	3.0	3.4	3.6	3.5	-3.5	3.0	-3.4
Body weight	5.6	24.6	33.5	5.8	3.6	5.3	4.7	-4.8	5.6	-4.6
Weight adjusted by age	0.9	2.6	4.5	2.1	0.9	1.7	1.4	-1.2	2.1	-1.5
Bone surface	0.0	0.1	0.3	0.5	-0.2	0.2	-0.0	0.0	-0.1	-0.1
Bone volume	0.1	0.1	0.2	0.3	0.4	0.4	0.4	-0.3	-0.1	-0.4
Breakpoint value in progressive ratio session	0.3	0.5	0.6	-0.6	-0.7	-0.7	-0.8	0.6	-0.4	0.8
Number of licking bursts	0.3	0.9	1.8	-0.3	-1.3	-0.9	-1.1	1.1	-0.3	1.0
Context. condit. distance diff. score	8.7	10.6	12.8	-2.5	-3.5	-3.3	-3.6	3.4	-2.7	3.6
Locomotion velocity, session 1	0.5	0.5	0.8	-0.4	-0.9	-0.8	-0.8	0.7	-0.4	0.8
Locomotion distance, session 1	0.1	0.2	0.6	-0.7	0.4	-0.2	0.1	-0.1	-0.7	0.1
Locomotion velocity, session 2	0.1	0.1	0.2	0.0	-0.4	-0.2	-0.3	0.3	0.1	0.3
Locomotion distance, session 2	0.2	0.2	0.5	-0.7	-0.2	-0.5	-0.4	0.5	-0.5	0.5
Locomotion velocity, session 3	0.2	0.2	0.6	0.0	0.8	0.4	0.6	-0.6	0.0	-0.6
Locomotion distance, session 3	1.0	1.1	1.8	-1.4	-0.6	-1.1	-1.0	1.0	-1.3	1.0
Stereotopy head waving bouts, day 3	0.9	1.0	2.6	1.6	0.1	1.0	0.6	-0.6	1.6	-0.7
Stereotopy head waving duration, day 3	0.7	0.9	2.0	1.4	0.2	0.9	0.7	-0.7	1.4	-0.7
Locomotion velocity, session 7	4.4	4.8	6.0	-2.4	-1.8	-2.4	-2.1	2.0	-2.4	2.2
Locomotion distance, session 7	3.1	4.0	6.2	-2.5	-1.3	-2.1	-1.8	1.7	-2.5	1.9
Stereotopy head waving bouts, day 7	2.6	3.0	4.1	2.0	1.2	1.8	1.6	-1.6	2.0	-1.7
Stereotopy head waving duration, day 7	2.5	3.1	4.3	2.1	1.2	1.8	1.6	-1.7	2.1	-1.7
Locomotion velocity, session 8	1.6	1.9	4.8	0.3	-2.2	-1.0	-1.6	1.5	0.4	1.6
Locomotion distance, session 8	4.6	6.6	7.9	-2.0	-2.7	-2.7	-2.8	2.7	-2.2	2.8
Degree of sensitization distance	0.7	0.7	1.3	-0.4	-1.1	-0.9	-1.0	0.9	-0.6	0.9
Degree of sensitization stereotypy	1.3	1.4	1.7	1.3	0.9	1.2	1.2	-1.2	1.3	-1.2
Conditioned locomotion	0.5	0.6	2.2	1.0	0.2	0.7	0.5	-0.4	1.5	-0.5
Cocaine response after cond. corrected	0.3	0.5	0.8	-0.9	-0.5	-0.8	-0.7	0.7	-0.7	0.7
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.4	-0.5	-0.0	-0.3	0.2	0.5	0.3
Cocaine response before conditioning	3.0	3.6	7.6	2.8	0.7	2.0	1.5	-1.5	2.6	-1.5
Saline control response	2.5	3.5	5.0	1.2	2.2	1.9	2.1	-2.1	1.2	-2.1
Bone: connectivity density	2.1	3.4	5.3	-2.1	-1.3	-1.9	-1.7	1.6	-2.3	1.7
Bone: cortical apparent density	0.6	1.0	2.2	0.2	1.5	0.9	1.2	-1.0	0.5	-1.1
Bone: cortical area	1.4	2.3	3.1	1.8	1.1	1.6	1.4	-1.4	1.7	-1.5
Bone: cortical porosity	0.6	0.7	0.9	0.9	0.7	0.9	0.8	-0.7	0.7	-0.9
Bone: cortical porosity	0.3	0.4	0.9	0.9	0.2	0.7	0.5	-0.4	0.7	-0.5
Bone: cortical thickness	4.5	7.4	10.1	1.9	3.2	2.8	3.1	-2.8	2.0	-3.0
Bone: cortical thickness	2.1	2.6	4.6	0.5	2.2	1.4	1.9	-2.0	0.6	-1.7
Bone: cortical tissue density	0.5	0.8	1.7	0.1	1.3	0.8	1.1	-0.9	0.4	-0.9
Condit. Reinf. active minus inactive responses	0.7	0.8	1.0	-1.0	-0.8	-1.0	-0.9	1.0	-0.8	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.0	0.4	0.2	0.4	-0.4	0.2	-0.5
Condit. Reinf. active responses	1.2	1.5	2.0	-1.4	-0.8	-1.3	-1.1	1.3	-1.4	1.2
Condit. Reinf. inactive responses	1.6	2.1	4.1	-1.9	-0.5	-1.4	-1.1	1.2	-2.0	1.4
Incentive salience index mean	2.1	2.7	3.5	-1.3	-1.8	-1.7	-1.8	1.9	-1.2	1.7
Condit. Reinf. lever presses	3.9	5.9	7.7	-1.7	-2.8	-2.5	-2.7	2.6	-1.8	2.6
Condit. Reinf. active minus inactive responses	0.6	0.9	2.0	1.3	0.5	1.0	0.8	-0.6	1.4	-0.8
Condit. Reinf. active-inactive response ratio	1.1	1.7	4.1	1.9	0.4	1.3	1.0	-0.7	2.0	-1.0
Condit. Reinf. active responses	0.1	0.1	0.2	-0.1	-0.3	-0.2	-0.3	0.4	-0.2	0.3
Condit. Reinf. inactive responses	1.2	1.7	3.2	-1.6	-0.8	-1.4	-1.1	1.1	-1.8	1.2
Condit. Reinf. lever presses	0.7	1.0	1.1	-1.0	-0.9	-1.1	-1.0	0.9	-1.1	1.0
Condit. Reinf. lever reinforcers received	0.2	0.2	0.5	-0.3	-0.5	-0.4	-0.5	0.7	-0.3	0.5
Conditioned reinforcement - actives	0.4	1.7	2.1	1.2	1.4	1.4	1.4	-1.0	1.2	-1.5
Conditioned reinforcement - inactives	0.7	2.0	2.8	1.1	1.6	1.5	1.5	-1.1	1.7	-1.3
Conditioned locomotion	0.1	0.2	0.3	0.6	0.2	0.5	0.3	0.3	0.6	-0.6
Patch foraging indifference point 0 sec	0.5	1.3	2.7	0.3	1.6	1.1	1.3	-1.5	0.6	-1.0
Patch foraging indifference point AUC	0.6	1.4	2.0	1.4	0.9	1.3	1.1	-0.8	1.1	-1.4
Delay disc. indifference point, 0s delay	0.2	0.2	0.7	0.8	0.1	0.5	0.3	-0.0	0.7	-0.2
Delay disc. indifference point, 16s delay	2.0	2.8	4.7	1.1	2.2	1.8	2.0	-1.5	1.0	-1.8
Delay disc. indifference point, 2s delay	1.2	1.3	2.7	1.6	0.6	1.2	0.9	-0.9	1.6	-0.8
Delay disc. indifference point, 24s delay	0.3	0.5	0.7	0.6	0.9	0.8	0.8	-0.8	0.2	-0.8
Delay disc. indifference point, 4s delay	2.2	2.3	5.6	1.9	0.8	1.6	1.3	-1.0	2.4	-1.0
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.6	0.6	0.6	0.6	-0.4	0.7	-0.6
Indifference point function ln k	0.2	0.6	1.0	-0.5	-1.0	-0.8	-0.9	0.8	-0.3	0.8
Indifference point function log k	0.2	0.6	1.0	-0.5	-1.0	-0.8	-0.9	0.8	-0.3	0.8
Patch foraging total patch changes 0 sec	0.7	1.9	3.7	0.5	1.9	1.3	1.6	-1.7	0.6	-1.3
Patch foraging total patch changes 12 sec	1.5	2.0	3.5	0.7	1.9	1.4	1.6	-1.6	0.7	-1.6
Patch foraging total patch changes 18 sec	0.6	1.4	3.7	-0.2	1.9	0.9	1.4	-1.3	-0.3	-1.3
Patch foraging total patch changes 24 sec	0.2	0.7	1.9	-1.0	1.4	0.2	0.7	-0.8	-0.9	-0.5
Patch foraging total patch changes 6 sec	1.3	2.2	4.5	0.3	2.1	1.3	1.7	-1.9	0.5	-1.5
Patch foraging time to switch 0 sec	0.0	0.2	0.6	-0.7	0.5	-0.2	0.1	-0.1	-0.5	0.0
Patch foraging water rate 0 sec	0.3	1.1	1.5	0.9	0.9	1.0	1.1	-1.2	1.1	-1.2
Patch foraging water rate 12 sec	0.0	0.1	0.4	-0.3	0.6	0.2	0.4	-0.1	-0.1	-0.2
Patch foraging water rate 18 sec	0.1	0.3	0.6	0.6	0.3	0.5	0.5	-0.2	0.7	-0.4
Patch foraging water rate 24 sec	1.8	2.6	3.6	1.5	1.5	1.7	1.7	-1.7	1.2	-1.9
Patch foraging water rate 6 sec	0.2	0.3	0.6	-0.0	0.8	0.4	0.6	-0.6	-0.2	-0.6
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.8	0.7	0.3	0.6	0.6	-0.5	0.9	-0.6
Distance traveled before self-admin	0.1	0.2	0.5	0.5	-0.6	-0.1	-0.4	0.7	0.6	0.2
Distance traveled after self-admin	0.4	0.7	1.8	1.3	0.1	0.8	0.5	-0.7	1.2	-0.5
Extensor digitorum longus weight	0.0	0.2	0.5	0.3	-0.7	-0.2	-0.5	0.4	-0.2	0.3
Bone: elastic displacement	0.5	0.7	1.1	0.3	1.0	0.8	0.9	-1.0	0.7	-0.8
Bone: elastic work	2.6	3.4	3.8	1.7	1.7	1.9	1.9	-1.9	1.9	-1.9
Bone: endosteal estimation	0.7	1.6	5.7	2.4	-1.3	0.7	-0.3	0.0	1.9	0.1
Bone: endosteal perimeter	0.9	2.3	6.4	0.4	-2.5	-1.1	-1.8	1.5	0.0	1.7
Epididymis fat weight	3.1	15.6	33.5	0.6	5.8	3.5	4.7	-4.7	1.3	-4.2
Delta time in closed arm before/after self-admin	0.5	0.4	0.6	0.6	0.6	0.7	0.7	-0.8	0.6	-0.7
Delta time in open arm before/after self-admin	0.2	0.3	0.9	0.5	0.3	0.4	0.4	-0.2	1.0	-0.4
Diff in mean of infusions in LGA sessions	2.6	4.6	6.1	-2.5	-1.4	-2.2	-2.0	2.4	-2.2	2.2
Delay discount exponential model param	1.3	1.8	2.5	-1.4	-1.2	-1.5	-1.4	1.1	-1.6	1.1
Extinction: sum of active levers before priming	0.5	0.8	1.1	-0.8	-0.8	-0.8	-0.9	1.0	-0.9	1.0
Active lever presses in extinction session 6	0.2	0.2	0.4	-0.5	0.5	0.0	0.2	-0.4	-0.6	-0.0
Bone: final force	6.0	9.8	11.5	3.0	3.0	3.3	3.3	-3.4	2.7	-3.2
Bone: final moment	5.3	8.6	9.8	2.8	2.8	3.1	3.1	-3.1	2.6	-3.0
Food consumed during 24 hour testing period	0.2	0.4	1.1	1.0	-0.1	0.5	0.3	-0.3	1.0	-0.3
Glucose	3.1	4.9	10.0	-0.5	-3.2	-2.0	-2.6	2.8	-0.6	2.3
Heart weight	1.8	2.9	3.6	1.9	1.3	1.8	1.6	-1.8	1.5	-1.9
Delay discount hyperbolic model param	1.5	1.9	2.7	-1.5	-1.2	-1.5	-1.4	1.1	-1.6	1.2
Intermittent access intake day 1-15 change	0.0	0.1	0.2	-0.2	-0.2	-0.2	-0.2	0.1	-0.4	0.2
Intermittent access intake escalation	0.0	0.1	0.2	0.1	0.4	0.2	0.4	-0.4	-0.1	-0.2
Intermittent access intake escalation 2	0.1	0.1	0.4	0.2	-0.6	-0.3	-0.4	0.1	-0.2	0.6
Intermitt. access day 1 inactive lever presses	0.0	0.3	0.7	0.8	-0.5	0.2	-0.1	0.2	0.9	-0.2
Intermitt. access day 15 inactive lever presses	0.2	1.3	1.9	1.4	0.8	1.2	1.1	-1.3	0.9	-1.2
Intermitt. access escalation Index	1.2	3.8	4.6	-2.0	-1.8	-2.1	-2.1	1.9	-1.7	1.9
Intermittent access day 1 total infusions	0.0	0.1	0.2	-0.5	0.4	-0.1	-0.0	0.3	-0.0	-0.0
Intermittent access day 15 total infusions	0.1	0.1	0.4	0.0	0.7	0.4	0.4	-0.2	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.3	0.5	1.0	0.4	1.0	0.8	0.8	-0.6	0.5	-0.7
Intermittent access total infusions	0.2	0.2	0.6	0.2	0.8	0.5	0.5	-0.2	0.3	-0.5
Intermittent access day 1 locomotion	0.1	0.1	0.4	-0.3	-0.2	-0.3	-0.4	0.6	0.1	0.1
Intermittent access day 15 total locomotion	0.3	1.2	2.5	1.5	0.7	1.2	0.9	-0.5	1.6	-1.0
Intermittent access total locomotion	0.8	1.0	2.0	1.2	0.7	1.1	0.8	-0.4	1.4	-1.0
Intermittent access standard deviation	0.7	3.5	4.2	1.6	2.0	2.0	2.1	-1.9	1.6	-1.9
Left kidney weight	2.6	21.1	23.8	4.9	3.7	4.9	4.5	-4.7	4.8	-4.6
Right kidney weight	3.0	20.9	26.1	5.1	3.5	4.9	4.4	-4.4	5.1	-4.4
Cocaine induced anxiety	0.4	1.1	1.8	-0.7	-1.3	-1.1	-1.2	1.3	-0.7	1.0
Post-drug Anxiety	0.6	0.7	0.8	-0.7	-0.9	-0.9	-0.8	0.8	-0.7	0.8
Baseline Anxiety	0.1	0.2	0.7	-0.9	0.3	-0.3	0.1	-0.1	-0.7	0.3
Tail length	1.7	9.0	21.9	4.7	0.9	3.1	2.1	-2.0	4.1	-2.3
Length with tail	3.2	14.3	33.8	5.8	1.1	3.9	2.7	-2.7	5.1	-2.9
Length without tail	2.2	11.4	21.5	4.6	1.5	3.5	2.7	-3.0	4.4	-2.8
Times rat made contact with spout	0.6	0.6	2.0	-1.4	0.4	-0.6	-0.1	-0.3	-1.4	0.2
Lifetime Intake	0.4	0.5	0.8	0.6	0.9	0.8	0.7	-0.4	0.7	-0.7
Liver weight, left	0.5	0.9	2.2	1.1	-1.5	-0.1	-0.8	0.4	1.3	0.7
Liver weight, right	1.0	1.7	5.6	2.4	-0.6	1.0	0.3	-0.4	2.2	-0.4
Locomotor activity	0.4	0.6	1.7	1.3	-1.1	0.2	-0.3	-0.1	1.2	0.2
Locomotor testing distance	0.1	0.2	0.8	0.4	-0.9	-0.2	-0.5	0.3	0.4	0.4
Locomotor testing rearing	0.1	0.2	0.8	0.8	-0.4	0.2	-0.0	-0.1	0.9	-0.1
Locomotion in novel chamber	0.6	0.8	1.1	1.0	0.8	1.0	0.9	-0.9	1.0	-0.7
Locomotion in novel chamber post-restriction	0.5	1.6	2.1	1.0	1.2	1.3	1.3	-1.4	1.4	-1.1
Fecal boli incidents, locomotor time 1	0.3	0.8	1.7	-0.9	-0.6	-0.9	-0.8	0.7	-1.3	0.7
Change in fecal boli incidents, locomotor task	0.7	0.7	1.5	1.0	0.4	0.8	0.7	-1.0	1.2	-0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.9	1.0	-0.4	0.4	0.0	-0.5	0.8	0.1
Bouts of movement, locomotor time 1	0.9	1.1	1.5	-0.9	-1.2	-1.2	-1.2	1.0	-1.0	0.9
Total resting periods, locomotor time 1	0.6	0.7	1.2	-0.5	-1.1	-0.9	-1.0	0.8	-0.6	0.7
Rest time, locomotor task time 1	0.1	0.1	0.4	0.5	-0.6	-0.1	-0.3	-0.0	0.4	0.1
Distance moved, locomotor task time 1	0.3	0.8	1.2	0.7	1.1	1.0	1.0	-0.9	0.5	-0.9
Vertical activity count, locomotor time 1	0.1	0.5	0.8	0.4	0.9	0.7	0.9	-0.9	0.4	-0.7
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.4	0.3	-0.6	-0.2	-0.4	0.0	0.4	0.2
Bouts of movement, locomotor time 2	0.1	0.4	1.5	0.8	-0.6	0.1	-0.1	-0.3	1.2	-0.3
Total resting periods, locomotor time 2	0.1	0.4	1.1	0.6	-1.0	-0.2	-0.5	0.1	1.0	0.1
Rest time, locomotor task time 2	1.0	1.6	4.3	-0.1	-2.1	-1.2	-1.6	1.2	-0.2	1.3
Distance moved, locomotor task time 2	1.5	2.0	3.5	0.7	1.9	1.4	1.7	-1.6	0.8	-1.4
Vertical activity count, locomotor time 2	0.1	0.3	0.7	-0.0	0.8	0.4	0.7	-0.7	-0.0	-0.3
Light reinforcement 1	0.1	0.2	0.6	0.1	0.8	0.5	0.6	-0.4	0.0	-0.5
Light reinforcement 2	0.2	0.5	1.3	1.0	0.2	0.7	0.5	-0.4	1.1	-0.6
Bone: marrow area	0.7	1.6	5.6	2.4	-1.3	0.7	-0.2	0.0	1.9	0.0
Bone: maximum diameter	0.3	0.5	1.5	1.0	-1.2	-0.1	-0.7	0.5	0.6	0.4
Bone: maximum force	3.9	7.7	8.9	2.8	2.5	3.0	2.8	-2.9	2.5	-2.8
Bone: maximum moment	3.5	6.6	7.6	2.7	2.2	2.8	2.6	-2.7	2.5	-2.5
Mean time between licks in bursts	0.3	1.8	4.0	0.0	-2.0	-1.1	-1.5	1.6	0.0	1.5
Mean num. licks in bursts	0.3	0.8	2.1	-0.4	1.4	0.5	1.0	-1.2	-0.4	-0.8
Cd content in liver	0.1	0.1	0.2	-0.5	0.4	0.0	0.2	-0.2	0.3	0.1
Co content in liver	1.3	1.5	2.7	0.6	1.7	1.3	1.5	-1.3	0.5	-1.4
Cu content in liver	1.1	1.3	3.4	-1.8	0.1	-1.0	-0.5	0.9	-1.7	0.7
Fe content in liver	1.1	1.4	2.1	0.6	1.4	1.2	1.4	-1.3	0.9	-1.3
K content in liver	0.2	0.2	1.0	-0.4	0.2	-0.1	0.0	0.1	-1.0	-0.2
Mg content in liver	1.6	1.8	2.4	-0.9	-1.4	-1.3	-1.4	1.5	-1.5	1.2
Mn content in liver	4.2	4.8	7.3	-1.1	-2.7	-2.1	-2.5	2.6	-1.7	2.2
Na content in liver	0.7	0.8	1.6	0.3	1.3	0.9	1.1	-0.7	0.0	-1.2
Rb content in liver	1.0	1.1	2.1	-1.2	-0.7	-1.1	-0.9	1.0	-1.5	1.0
Se content in liver	1.4	1.7	3.9	-0.1	-2.0	-1.1	-1.5	1.6	-0.2	1.3
Sr content in liver	0.3	0.2	0.6	0.8	-0.0	0.5	0.3	-0.3	0.7	-0.4
Zn content in liver	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.4	0.3	-0.3	0.4
Bone: minimum diameter	0.4	0.7	1.8	1.1	-1.3	-0.1	-0.7	0.5	0.8	0.6
Time in familiar zone, hab. session 1	1.1	1.2	4.1	-2.0	0.0	-1.1	-0.6	0.4	-1.4	0.7
Time in novel zone, hab. session 1	0.5	0.5	2.1	1.5	-0.3	0.7	0.2	-0.2	1.0	-0.3
Total zone transitions, hab. session 1	0.6	0.8	1.2	-1.0	-0.5	-0.9	-0.8	0.9	-1.1	0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.8	-0.9	-0.3	-0.7	-0.5	0.4	-0.8	0.5
Locomotion velocity, hab. session 1	0.1	0.1	0.3	-0.5	0.1	-0.3	-0.1	0.1	-0.5	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.4	-0.6	0.3	-0.2	0.0	-0.1	-0.2	0.1
Time in novel zone, hab. session 2	0.1	0.2	0.4	0.6	0.2	0.4	0.3	-0.3	0.3	-0.4
Total zone transitions, hab. session 2	0.0	0.0	0.1	-0.1	0.3	0.1	0.3	-0.2	-0.0	-0.2
Total locomotion distance, hab. session 2	0.5	0.7	1.6	-1.3	-0.4	-0.9	-0.7	0.6	-1.0	0.7
Locomotion velocity, hab. session 2	0.6	0.9	1.7	-1.3	-0.5	-1.0	-0.8	0.7	-1.1	0.8
Novel to familiar place preference ratio	0.1	0.1	0.2	0.0	0.4	0.2	0.3	-0.1	-0.4	-0.4
Novelty place preference	0.1	0.1	0.3	0.3	0.4	0.4	0.4	-0.2	-0.1	-0.5
Time in novel zone, NPP test	0.2	0.2	0.4	0.5	0.5	0.5	0.5	-0.3	0.1	-0.6
Total zone transitions, NPP test	0.9	1.3	1.8	-1.3	-0.9	-1.2	-1.1	1.1	-1.2	1.2
Total locomotion distance, NPP test	0.6	0.8	1.7	-1.3	-0.3	-0.9	-0.7	0.5	-1.2	0.7
Locomotion velocity, NPP test	1.1	1.6	3.1	-1.8	-0.5	-1.3	-1.0	0.9	-1.7	1.0
Intraocular pressure	0.5	0.9	1.4	-1.2	-0.6	-1.0	-0.9	0.7	-1.0	1.0
Delta distance traveled before/after self-admin	1.9	2.1	3.0	1.5	1.2	1.5	1.4	-1.7	1.3	-1.3
Delta ambulatory time before/after self-admin	0.9	1.5	2.7	1.3	0.8	1.2	1.1	-1.6	1.3	-1.0
Parametrial fat weight	1.0	2.4	2.9	1.6	1.5	1.7	1.6	-1.5	1.2	-1.7
Pavlov. Cond. lever latency	2.1	2.6	5.0	0.4	2.2	1.5	1.9	-2.0	0.5	-1.8
Pavlov. Cond. magazine entry latency	2.7	3.5	5.9	-1.0	-2.4	-1.9	-2.2	2.0	-0.9	2.2
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	0.8	-0.8	0.0	-0.3	0.4	0.6	0.3
Pavlov. Cond. index score	3.2	4.0	7.2	-0.9	-2.7	-2.0	-2.3	2.3	-0.8	2.3
Pavlov. Cond. latency score	2.5	3.1	6.1	-0.5	-2.5	-1.7	-2.1	2.1	-0.5	2.0
Pavlov. Cond. lever contacts	1.7	2.1	4.5	-0.3	-2.1	-1.3	-1.7	1.7	-0.3	1.6
Pavlov. Cond. magazine entry number	3.3	4.2	6.0	1.4	2.5	2.1	2.3	-2.1	1.2	-2.3
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	-0.8	1.0	0.0	0.5	-0.3	-0.8	-0.3
Pavlov. Cond. lever-magazine prob. diff.	3.5	4.3	7.3	-1.0	-2.7	-2.1	-2.4	2.3	-0.9	2.4
Pavlov. Cond. response bias	3.6	4.5	7.3	-1.2	-2.7	-2.1	-2.4	2.3	-1.1	2.4
Pavlov. Cond. lever latency	0.1	0.2	0.6	0.8	0.1	0.5	0.3	-0.2	0.5	-0.3
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.7	0.0	0.4	0.3	-0.3	0.7	-0.4
Pavlov. Cond. change in total contacts	0.1	0.3	0.5	0.4	0.5	0.5	0.6	-0.4	0.4	-0.7
Pavlov. Cond. index score	0.0	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.1	0.2	0.0
Pavlov. Cond. latency score	0.0	0.0	0.1	0.2	0.1	0.2	0.2	-0.1	0.3	-0.2
Pavlov. Cond. lever contacts	0.0	0.1	0.3	-0.5	-0.0	-0.3	-0.1	0.1	-0.3	0.1
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.6	-0.3	-0.5	-0.4	0.5	-0.7	0.5
Pavlov. Cond. intertrial magazine entries	1.2	2.7	3.7	-1.1	-1.9	-1.6	-1.8	1.9	-1.1	1.9
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	-0.0	-0.2	-0.1	-0.1	0.1	0.1	0.1
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.4	-0.5	-0.5	-0.5	0.4	-0.2	0.4
Time in closed arm before self-admin	0.1	0.1	0.1	-0.3	-0.3	-0.3	-0.3	0.4	-0.4	0.1
Time in closed arm after self-admin	1.0	1.1	1.6	0.8	1.3	1.1	1.2	-1.1	0.5	-1.2
Time in open arm before self-admin	0.5	0.6	1.2	-0.5	-0.9	-0.7	-0.9	0.7	-0.6	1.1
Time in open arm after self-admin	0.5	0.5	1.0	-0.3	-0.9	-0.7	-0.8	0.6	0.1	1.0
Bone: periosteal estimation	0.9	2.2	6.3	2.5	-0.1	1.4	0.7	-0.8	2.2	-0.9
Bone: periosteal perimeter	0.2	0.5	1.8	1.3	-0.7	0.4	-0.1	0.0	1.0	-0.0
Bone: post-yield work	0.9	1.6	3.8	-0.1	-1.9	-1.1	-1.5	1.3	-0.2	1.4
Progressive ratio test 1 active lever presses	0.1	0.2	0.4	0.1	0.6	0.4	0.4	0.0	0.4	-0.5
Progressive ratio test 1 breakpoint	0.1	0.2	0.4	0.2	0.7	0.5	0.4	-0.0	0.5	-0.6
Progressive ratio test 1 inactive lever presses	0.2	0.5	1.3	-0.1	1.2	0.6	0.8	-0.5	-0.0	-0.8
Progressive ratio test 2 active lever presses	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.0	0.4	-0.0	0.2
Progressive ratio test 2 breakpoint	0.1	0.1	0.2	-0.5	0.4	-0.1	0.0	0.3	-0.0	0.2
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.6	0.7	0.4	0.6	0.4	-0.3	0.6	-0.5
Incentive Sensitization - Responses	0.2	0.6	1.0	-0.9	-0.5	-0.8	-0.7	0.7	-0.6	1.0
Incentive Sensitization - Breakpoint	0.2	0.5	0.9	-0.9	-0.4	-0.8	-0.6	0.7	-0.6	0.9
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	-0.7	-0.7	-0.7	-0.7	0.5	-0.7	0.9
Progressive ratio	2.8	8.2	9.4	2.8	2.5	3.0	2.8	-3.0	2.8	-3.1
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.3	-0.0	-0.2	-0.1	-0.0	-0.6	-0.1
Seeking ratio, punishment vs. effort	2.9	6.5	7.4	-2.6	-2.2	-2.7	-2.5	2.5	-2.7	2.5
Retroperitoneal fat weight	0.4	1.9	2.2	1.4	1.3	1.5	1.4	-1.3	1.5	-1.3
Reaction time number correct	0.3	1.0	2.1	0.1	1.5	0.9	1.2	-1.3	-0.0	-1.1
Reaction time mean minus median	0.3	2.2	5.3	0.1	-2.3	-1.2	-1.7	1.7	0.4	1.7
Reaction time mean minus median AUC	0.3	1.8	4.1	-0.2	-2.0	-1.2	-1.6	1.5	0.4	1.6
Reaction time num false alarms	0.2	0.3	1.0	0.8	0.2	0.5	0.4	-0.2	1.0	-0.4
Reaction time num false alarms AUC	0.2	0.6	1.4	1.0	0.3	0.7	0.6	-0.4	1.2	-0.6
Reaction time trials correct on left	0.3	1.0	2.1	0.1	1.5	0.9	1.2	-1.3	-0.0	-1.1
Reaction time trials on left	0.3	1.0	2.0	0.2	1.4	0.9	1.2	-1.3	0.1	-1.1
Reaction time mean	1.5	3.3	6.8	-0.3	-2.6	-1.6	-2.1	2.2	-0.1	2.0
Reaction time mean AUC	1.3	3.2	6.8	-0.3	-2.6	-1.6	-2.1	2.2	-0.0	2.0
Median of all reaction times	1.5	2.3	4.5	-0.3	-2.1	-1.4	-1.7	1.9	-0.3	1.6
Reaction time omissions	1.2	1.9	4.1	-0.1	-2.0	-1.1	-1.6	1.7	0.2	1.7
Reaction time false alarm rate	0.2	0.3	1.0	0.8	-0.6	0.1	-0.2	0.5	1.0	0.1
Reaction time premature initiation rate	1.3	2.0	2.8	1.5	1.3	1.6	1.4	-1.3	1.2	-1.7
Reaction time premature initiations	1.2	3.6	5.1	1.6	2.1	2.0	2.1	-2.0	1.2	-2.3
Std. dev. reaction times	0.7	2.3	5.6	0.3	-2.4	-1.1	-1.7	1.7	0.8	1.7
Reaction time trials completed	0.3	1.0	2.0	0.2	1.4	0.9	1.2	-1.3	0.1	-1.1
Reaction time trials AUC	0.3	0.9	1.8	0.1	1.4	0.8	1.1	-1.2	-0.1	-1.0
Run reversals in cocaine runway, females	0.2	0.2	0.6	-0.1	0.8	0.4	0.5	-0.5	-0.4	-0.3
Run reversals in cocaine runway, males	0.5	0.6	1.7	1.3	-0.6	0.4	-0.1	0.1	1.3	-0.0
Latency to leave start box in cocaine runway	0.1	0.1	0.2	-0.3	-0.4	-0.4	-0.4	-0.1	-0.4	0.2
Latency to leave start box in cocaine runway, F	0.4	0.5	0.8	-0.7	-0.7	-0.8	-0.8	0.4	-0.9	0.7
Latency to leave start box in cocaine runway, M	0.8	0.7	1.1	0.9	0.7	0.9	0.8	-1.1	0.8	-0.9
Std. dev. time between licks in bursts	0.6	1.2	3.3	0.4	-1.8	-0.7	-1.3	1.1	0.1	1.1
Total sessions with >9 infusions	0.5	0.6	0.8	0.6	0.9	0.8	0.8	-0.4	0.8	-0.8
Short access day 1 total inactive lever presses	0.8	1.7	3.9	2.0	0.4	1.3	0.8	-0.6	1.9	-1.0
Short access day 10 total inactive lever presses	0.0	0.3	0.4	-0.4	-0.5	-0.6	-0.6	0.5	-0.7	0.5
Short access day 1 total infusions	0.0	0.0	0.1	-0.0	0.2	0.1	0.0	0.3	0.3	-0.0
Short access day 10 total infusions	0.2	0.4	0.8	0.5	0.9	0.7	0.7	-0.4	0.6	-0.5
Short access total infusions	0.5	0.7	1.1	0.7	1.0	0.9	0.9	-0.5	1.0	-0.9
Short access day 1 locomotion	0.9	1.5	2.1	-1.3	-0.9	-1.2	-1.2	1.4	-1.1	1.2
Short access day 10 total locomotion	0.1	0.2	0.8	0.7	-0.4	0.3	-0.0	0.2	0.9	-0.2
Short access total locomotion	0.1	0.1	0.5	0.1	-0.3	-0.1	-0.3	0.7	0.2	-0.0
One hour access (0.3 mA shock)	1.2	1.4	1.9	-1.4	-0.8	-1.2	-1.2	1.2	-1.3	1.2
Compulsive drug intake	3.6	5.3	6.2	-2.0	-2.3	-2.4	-2.5	2.5	-2.2	2.1
One hour access (shock baseline)	0.2	0.6	0.9	0.6	1.0	0.8	0.9	-0.9	0.7	-0.6
Social response proportion	0.1	0.1	0.2	0.4	-0.4	-0.0	-0.2	0.2	0.3	0.3
Social responses	0.2	0.2	0.4	0.7	0.2	0.5	0.4	-0.5	0.5	-0.2
Social time	0.8	1.2	3.3	0.5	-1.8	-0.7	-1.3	1.1	0.3	1.3
Soleus weight	0.5	1.4	4.6	1.2	-2.2	-0.5	-1.3	1.1	0.3	0.8
Bone: stiffness	0.9	1.7	2.2	1.0	1.4	1.3	1.4	-1.5	0.8	-1.3
Tibialis anterior weight	0.3	1.0	2.4	0.1	1.5	0.9	1.2	-1.1	-0.2	-1.1
Time to tail flick, vehicle, before self-admin	0.9	1.1	1.4	-1.0	-1.1	-1.2	-1.1	1.2	-1.1	0.7
Time to tail flick, vehicle, after self-admin	0.6	1.2	1.9	-0.7	-1.4	-1.1	-1.3	1.2	-0.6	1.3
Time to tail flick, test, before self-admin	0.0	0.1	0.1	-0.3	-0.1	-0.2	-0.2	-0.0	-0.4	0.3
Time to tail flick, test, after self-admin	0.6	0.6	0.9	-0.7	-0.9	-0.9	-0.8	0.8	-0.6	0.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	-0.2	0.1	-0.1	-0.0	-0.1	-0.1	0.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.5	-0.7	-0.2	-0.5	-0.3	0.4	-0.6	0.3
Tibia length	1.1	3.2	8.2	2.9	0.1	1.7	1.0	-1.3	2.7	-1.1
Ambulatory time before self-admin	0.0	0.1	0.4	0.5	-0.2	0.1	-0.0	0.5	0.6	-0.1
Ambulatory time after self-admin	0.7	1.2	2.4	1.5	0.3	1.1	0.7	-1.0	1.6	-0.9
Bone: tissue strength	4.2	4.4	5.3	2.2	1.9	2.3	2.1	-2.1	1.8	-2.2
Total heroin consumption	0.0	0.1	0.2	0.2	-0.4	-0.1	-0.3	0.1	0.1	0.2
Bone: trabecular number	0.6	1.1	2.8	-1.7	0.0	-1.0	-0.5	0.5	-1.7	0.7
Bone: trabecular spacing	2.2	3.3	6.3	2.5	0.8	1.9	1.4	-1.3	2.5	-1.6
Bone: trabecular thickness	0.6	0.8	2.0	-1.4	-0.2	-0.9	-0.6	0.6	-1.3	0.8
Bone: trabecular tissue density	1.3	2.3	3.3	1.6	1.2	1.5	1.5	-1.6	1.8	-1.4
Water consumed over 24 hours	0.0	0.0	0.1	0.1	-0.2	-0.1	-0.1	-0.2	-0.2	0.0
Number of responses in last shaping day	0.3	0.4	1.0	1.0	0.2	0.6	0.4	-0.3	1.0	-0.5