C1qtnf1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	NM_001007675.1	0.06	0.04	9.1e-08	0.05	0.06	0.06	0.06	1.2e-06	2.0e-07	3.1e-07	1.5e-07
2	Adipose	alternative polyA	XM_063269244.1	0.1	0.06	1.1e-12	0.1	0.11	0.11	0.11	1.0e-10	7.0e-12	2.8e-12	3.6e-12
3	Adipose	alternative polyA	NM_001007675.1	0.1	0.06	2.9e-12	0.09	0.1	0.11	0.11	2.1e-10	1.4e-11	7.0e-12	7.2e-12
4	Adipose	alternative TSS	XM_006247800.5	0.05	0.04	9.8e-07	0.05	0.04	0.05	0.04	7.5e-06	9.7e-06	2.6e-06	2.3e-05
5	Adipose	mRNA stability	C1qtnf1	0.06	0.04	5.9e-09	0.06	0.06	0.06	0.06	2.5e-07	1.4e-07	9.8e-08	2.7e-07
6	Adipose	gene expression	C1qtnf1	0.58	0.13	0.0e+00	0.52	0.56	0.56	0.56	6.8e-68	5.2e-74	1.4e-75	7.2e-75
7	OFC	gene expression	C1qtnf1	0.21	0.13	2.2e-03	0.01	0.04	-0	-0	1.4e-01	4.2e-02	4.4e-01	4.5e-01
8	LHb	gene expression	C1qtnf1	0.41	0.17	5.4e-05	0.17	0.03	0.1	0.06	9.6e-05	7.9e-02	2.4e-03	1.2e-02
9	Liver	gene expression	C1qtnf1	0.37	0.11	0.0e+00	0.4	0.38	0.47	0.34	1.3e-47	2.0e-44	1.0e-57	5.0e-39
10	Adipose	alternative TSS	NM_001007675.1	0.07	0.04	1.4e-08	0.05	0.06	0.07	0.06	1.9e-06	9.6e-08	2.3e-08	4.5e-07
11	Adipose	intron excision ratio	chr10_104174326_104176952	0.06	0.04	7.2e-04	0.01	0	0	0	2.3e-02	1.5e-01	1.5e-01	1.3e-01
12	pVTA	gene expression	C1qtnf1	0.06	0.04	1.2e-05	0.05	0.06	0.06	0.06	6.1e-05	1.4e-05	9.0e-06	1.0e-05
13	BLA	isoform ratio	XM_063269244.1	0.05	0.04	3.5e-03	0.03	0.02	0.03	0.02	6.5e-03	1.8e-02	1.4e-02	2.2e-02
14	PL	gene expression	C1qtnf1	0.04	0.03	2.1e-04	0.02	0.02	0.03	0.02	3.3e-03	1.3e-03	7.2e-04	3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11	12	13	14
Bone: apparent density	1.2	2.0	4.1	1.1	-1.1	1.1	1.6	1.2	1.0	-1.9	-2.0	-1.8	-1.3	0.9	-1.7	1.2	-1.3
Area under the delay curve	1.2	1.4	3.1	-1.0	1.6	-1.6	-1.2	-1.0	-1.8	1.0	-0.1	1.1	1.0	1.7	0.8	-1.3	0.3
BMI with tail	0.5	1.8	10.9	-0.4	-1.0	1.0	0.4	-0.8	1.1	1.0	2.6	0.5	-0.9	-3.3	0.8	0.1	0.5
BMI without tail	0.4	1.3	3.2	1.3	-1.5	1.5	1.6	0.7	1.3	-0.3	0.8	-0.5	-1.5	-1.8	-0.1	0.2	-0.6
Body weight	0.7	2.9	8.0	-1.5	0.7	-0.8	-0.7	-2.1	-0.7	2.3	2.8	2.0	0.5	-2.4	1.6	-2.1	1.0
Weight adjusted by age	0.2	0.3	1.2	-0.3	0.5	-0.5	-0.0	-0.4	-0.4	-0.3	-1.1	-0.3	0.0	0.9	-0.5	-0.6	0.2
Bone surface	1.2	2.1	10.0	-1.2	1.7	-1.6	-0.9	-0.8	-1.6	-0.4	-2.2	-0.1	1.0	3.2	-0.3	-0.5	-1.4
Bone volume	0.7	1.2	5.3	-0.4	0.6	-0.6	-0.1	-0.1	-0.6	-1.1	-2.3	-0.8	0.2	2.3	-0.9	0.3	-1.5
Breakpoint value in progressive ratio session	0.6	0.7	3.2	-0.5	0.2	-0.1	0.2	-0.5	0.2	-0.8	-1.2	-0.8	-1.1	1.0	-0.8	0.5	-1.8
Number of licking bursts	0.1	0.1	0.4	-0.2	0.2	-0.2	-0.0	-0.2	-0.2	0.3	0.3	0.3	0.2	-0.4	0.6	-0.4	0.1
Context. condit. distance diff. score	0.2	0.3	0.6	-0.6	0.6	-0.6	-0.6	-0.5	-0.6	0.0	-0.5	0.2	0.5	0.8	-0.5	-0.6	-0.4
Locomotion velocity, session 1	1.3	1.4	4.0	-0.6	0.8	-0.9	-0.9	-0.8	-1.1	1.5	1.3	1.4	1.1	-0.1	1.5	-1.5	2.0
Locomotion distance, session 1	1.9	2.4	4.5	2.1	-2.1	2.0	1.9	1.8	1.9	-1.3	-0.3	-1.4	-1.8	-1.0	-1.1	1.3	-0.1
Locomotion velocity, session 2	0.5	0.6	1.1	1.0	-1.0	1.0	1.0	0.8	1.0	-0.7	-0.2	-0.7	-1.0	-0.3	-0.9	0.5	0.2
Locomotion distance, session 2	4.7	6.6	11.4	3.2	-3.4	3.3	3.2	2.8	3.2	-2.3	-0.9	-2.5	-2.9	-1.2	-2.1	2.1	-0.4
Locomotion velocity, session 3	0.3	0.3	0.9	0.1	0.4	-0.4	-0.4	-0.0	-0.6	0.7	0.5	0.8	0.9	0.4	0.6	-0.9	0.6
Locomotion distance, session 3	0.5	0.5	1.9	0.7	-0.9	0.9	0.7	0.5	0.8	0.2	1.2	-0.0	-0.1	-1.4	0.3	0.6	-0.2
Stereotopy head waving bouts, day 3	1.5	1.7	4.0	-2.0	1.7	-1.7	-1.7	-1.8	-1.3	1.1	0.4	1.2	1.0	0.3	0.7	-1.1	1.0
Stereotopy head waving duration, day 3	1.4	1.7	3.9	-2.0	1.8	-1.8	-1.6	-1.8	-1.5	0.9	-0.0	1.0	1.1	0.9	0.5	-1.2	0.7
Locomotion velocity, session 7	0.2	0.2	1.4	0.3	0.2	-0.2	-0.0	0.2	-0.3	-0.2	-0.8	-0.3	-0.2	1.2	0.1	-0.1	-0.3
Locomotion distance, session 7	3.1	3.9	5.4	2.2	-2.0	2.0	2.2	2.0	2.0	-2.2	-2.0	-2.3	-2.3	0.5	-1.7	1.8	-1.7
Stereotopy head waving bouts, day 7	3.7	4.1	7.1	-2.7	2.6	-2.6	-2.7	-2.3	-2.4	1.8	0.8	1.9	2.4	0.7	1.3	-1.7	0.8
Stereotopy head waving duration, day 7	5.1	6.1	10.4	-3.2	3.2	-3.1	-3.0	-2.8	-3.0	2.1	0.9	2.3	3.0	1.2	1.5	-2.2	1.1
Locomotion velocity, session 8	0.9	1.1	3.0	-0.9	1.4	-1.4	-1.3	-0.8	-1.2	0.4	-0.7	0.5	0.8	1.7	0.3	-1.2	0.9
Locomotion distance, session 8	2.5	3.6	5.8	2.1	-2.2	2.2	2.2	1.8	2.1	-2.1	-1.6	-2.0	-2.1	0.0	-2.4	1.3	-1.3
Degree of sensitization distance	3.8	3.9	10.6	1.9	-1.4	1.4	1.9	1.8	1.3	-2.5	-3.3	-2.3	-2.2	1.9	-2.1	1.3	-1.6
Degree of sensitization stereotypy	1.4	1.5	2.8	-1.5	1.6	-1.5	-1.6	-1.2	-1.5	1.1	0.5	1.2	1.7	0.4	0.7	-0.9	0.2
Conditioned locomotion	0.3	0.3	0.8	0.4	-0.4	0.4	0.3	0.6	0.5	-0.8	-0.9	-0.7	-0.4	0.3	-0.6	0.5	-0.4
Cocaine response after cond. corrected	0.1	0.2	0.4	-0.6	0.4	-0.4	-0.4	-0.6	-0.2	0.4	0.4	0.4	0.3	-0.2	0.4	-0.5	-0.0
Cocaine response after cond. not corrected	0.1	0.1	0.4	-0.3	0.4	-0.4	-0.3	-0.4	-0.4	0.3	-0.1	0.3	0.3	0.4	0.3	-0.7	0.0
Cocaine response before conditioning	0.3	0.4	2.4	0.6	0.1	-0.1	0.3	0.3	-0.4	-0.3	-1.1	-0.2	0.0	1.6	-0.4	-0.4	0.1
Saline control response	0.4	0.5	2.1	0.9	0.2	-0.2	-0.2	0.6	-0.6	0.3	-0.3	0.4	0.5	1.4	0.2	-1.0	1.4
Bone: connectivity density	1.3	2.0	5.6	1.2	-0.9	0.9	1.5	1.4	0.7	-1.8	-2.4	-1.7	-1.2	1.6	-1.4	0.9	-1.3
Bone: cortical apparent density	1.9	2.6	4.7	1.3	-2.1	2.1	2.1	1.2	2.2	-1.1	0.2	-1.2	-2.0	-2.2	-1.0	1.5	0.0
Bone: cortical area	2.9	4.4	10.2	-2.4	1.5	-1.5	-1.7	-2.4	-1.2	2.6	3.2	2.4	1.4	-2.2	2.5	-1.6	1.8
Bone: cortical porosity	1.7	1.9	3.1	-1.8	1.7	-1.7	-1.8	-1.5	-1.4	1.3	0.4	1.2	1.4	0.8	1.1	-1.0	1.5
Bone: cortical porosity	2.8	3.0	5.4	-2.2	2.2	-2.2	-2.3	-1.9	-1.9	1.5	0.4	1.5	1.9	1.1	1.4	-1.4	1.6
Bone: cortical thickness	3.5	5.9	30.4	-0.3	-1.0	0.9	0.5	-0.7	1.0	2.4	4.9	1.9	-0.8	-5.5	2.6	-0.5	2.7
Bone: cortical thickness	1.8	2.1	11.8	0.0	-0.8	0.8	0.5	-0.3	0.7	1.3	2.9	1.1	-0.6	-3.4	1.2	-0.2	1.5
Bone: cortical tissue density	1.9	2.6	4.8	1.3	-2.1	2.1	2.1	1.2	2.2	-1.2	0.1	-1.3	-2.0	-2.0	-1.1	1.6	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.3	-0.2	0.2	0.2	0.6	0.2	-0.6	-0.7	-0.5	-0.5	0.7	-0.6	0.5	-0.4
Condit. Reinf. active-inactive response ratio	0.6	0.6	2.3	0.1	-0.1	0.1	0.4	0.4	0.2	-1.0	-1.5	-0.9	-0.5	1.5	-0.9	0.7	-0.7
Condit. Reinf. active responses	0.4	0.5	1.4	1.1	-0.7	0.7	0.6	1.2	0.6	-0.7	-0.6	-0.7	-0.8	0.4	-0.7	0.7	-0.2
Condit. Reinf. inactive responses	0.4	0.5	1.8	1.3	-0.9	0.9	0.7	1.2	0.8	-0.4	-0.0	-0.4	-0.8	-0.5	-0.4	0.4	-0.0
Incentive salience index mean	0.1	0.1	0.6	0.2	0.1	-0.1	-0.1	0.4	-0.1	-0.3	-0.5	-0.2	-0.1	0.8	-0.5	0.2	-0.2
Condit. Reinf. lever presses	0.1	0.2	0.6	0.7	-0.4	0.4	0.3	0.8	0.3	-0.4	-0.3	-0.3	-0.2	0.3	-0.8	0.3	-0.4
Condit. Reinf. active minus inactive responses	0.4	0.5	1.2	-0.4	0.9	-1.0	-0.7	-0.4	-1.0	0.3	-0.5	0.5	0.7	1.1	0.4	-1.0	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.8	-0.2	0.7	-0.7	-0.6	-0.3	-0.7	0.5	-0.1	0.5	0.6	0.8	0.5	-0.9	0.6
Condit. Reinf. active responses	0.2	0.3	1.6	0.4	-0.1	0.1	0.3	0.3	0.0	-0.8	-1.3	-0.6	-0.2	0.9	-0.7	-0.0	-0.5
Condit. Reinf. inactive responses	0.9	1.2	2.2	1.0	-0.9	0.9	1.0	1.0	0.8	-1.4	-1.5	-1.2	-0.8	0.6	-1.4	0.9	-1.1
Condit. Reinf. lever presses	1.2	1.7	4.1	1.2	-0.9	1.0	1.2	1.2	0.9	-1.8	-2.0	-1.5	-1.0	1.0	-1.8	1.1	-1.1
Condit. Reinf. lever reinforcers received	0.4	0.6	2.0	0.5	-0.4	0.4	0.6	0.5	0.4	-1.1	-1.4	-0.9	-0.5	0.6	-1.1	0.4	-0.9
Conditioned reinforcement - actives	0.7	1.2	3.2	0.8	-1.2	1.2	1.2	0.8	1.3	-0.9	-0.1	-1.1	-1.8	-1.3	-0.2	1.3	-0.9
Conditioned reinforcement - inactives	0.2	0.2	1.7	-0.2	0.1	-0.1	0.0	0.0	-0.1	0.3	0.5	0.2	-0.2	-1.3	1.0	0.4	0.3
Conditioned locomotion	1.2	1.6	4.1	1.0	-1.3	1.3	1.5	1.1	1.5	-1.4	-0.7	-1.5	-2.0	-1.1	-0.1	1.2	-1.0
Patch foraging indifference point 0 sec	1.3	2.4	4.6	1.5	-1.4	1.4	1.5	1.6	1.3	-1.8	-1.4	-1.6	-1.3	0.3	-2.2	1.8	-1.8
Patch foraging indifference point AUC	0.6	0.9	2.3	1.5	-0.6	0.6	0.7	1.4	0.4	-0.9	-1.4	-1.0	-0.7	1.5	-0.8	0.3	0.0
Delay disc. indifference point, 0s delay	1.0	1.1	3.0	-0.5	0.8	-0.8	-0.8	-1.0	-1.1	1.4	0.7	1.5	0.7	0.4	0.6	-1.7	1.4
Delay disc. indifference point, 16s delay	0.2	0.3	0.8	0.3	-0.1	0.1	0.1	0.6	0.2	-0.6	-0.9	-0.7	-0.1	0.8	-0.2	0.6	-0.5
Delay disc. indifference point, 2s delay	0.4	0.4	1.5	-0.2	0.6	-0.6	-0.1	-0.6	-1.2	0.7	-0.1	0.8	-0.2	1.0	-0.2	-0.9	-0.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.4	-0.2	0.4	-0.4	-0.1	0.0	-0.2	-0.0	-0.1	-0.1	0.3	0.6	0.6	-0.1	0.1
Delay disc. indifference point, 4s delay	1.2	1.3	2.7	-0.8	1.3	-1.3	-1.2	-1.0	-1.7	1.3	0.2	1.4	1.0	1.3	0.7	-1.2	0.8
Delay disc. indifference point, 8s delay	3.8	4.4	8.3	-2.1	2.6	-2.6	-2.1	-2.1	-2.9	2.1	0.7	2.3	2.1	1.8	1.6	-2.5	0.5
Indifference point function ln k	0.6	1.1	7.2	-0.2	-1.0	1.0	0.5	-0.1	1.3	0.0	1.4	-0.0	-0.6	-2.7	-0.2	1.2	-0.1
Indifference point function log k	0.6	1.1	7.2	-0.2	-1.0	1.0	0.5	-0.1	1.3	0.0	1.4	-0.0	-0.6	-2.7	-0.2	1.2	-0.1
Patch foraging total patch changes 0 sec	1.6	3.0	5.2	1.7	-1.6	1.7	1.8	1.8	1.6	-2.0	-1.5	-1.8	-1.6	0.2	-2.3	2.1	-1.9
Patch foraging total patch changes 12 sec	2.7	3.6	7.4	2.7	-2.0	1.9	1.8	2.5	1.8	-2.0	-1.6	-2.0	-1.7	0.5	-2.2	1.5	-1.0
Patch foraging total patch changes 18 sec	2.6	4.0	8.2	2.1	-1.2	1.3	1.5	2.1	1.1	-2.4	-2.9	-2.2	-1.4	2.2	-2.6	1.8	-2.3
Patch foraging total patch changes 24 sec	0.5	0.8	3.9	-0.2	1.0	-1.0	-1.2	0.0	-1.0	-0.2	-1.1	0.1	1.1	2.0	-0.7	-0.5	-0.0
Patch foraging total patch changes 6 sec	2.0	3.0	4.9	2.1	-2.0	2.0	2.1	1.9	1.8	-1.7	-1.1	-1.7	-2.0	0.1	-2.2	1.4	-1.0
Patch foraging time to switch 0 sec	0.2	0.5	1.0	-0.8	0.9	-0.8	-1.0	-0.7	-0.7	0.5	0.2	0.5	1.0	0.4	0.6	-0.7	0.4
Patch foraging water rate 0 sec	0.6	1.3	2.4	1.5	-1.2	1.2	1.6	1.2	0.9	-1.0	-0.8	-0.9	-1.4	0.2	-1.3	0.7	-1.3
Patch foraging water rate 12 sec	0.8	1.7	5.3	0.8	-1.7	1.7	0.9	0.8	2.2	-0.6	1.0	-0.8	-1.1	-2.3	-0.2	1.7	-0.5
Patch foraging water rate 18 sec	0.5	0.8	1.5	0.6	-1.0	1.0	0.9	0.6	1.1	-0.9	-0.5	-1.0	-0.9	-0.3	-1.2	1.0	-0.9
Patch foraging water rate 24 sec	1.8	2.5	3.7	1.6	-1.6	1.6	1.3	1.7	1.8	-1.9	-1.6	-1.9	-1.2	0.3	-1.8	1.8	-1.6
Patch foraging water rate 6 sec	0.6	0.8	4.0	0.6	-1.0	1.0	0.2	0.3	1.1	0.1	1.4	-0.1	-0.4	-2.0	-0.1	0.5	1.3
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.5	0.5	-0.2	0.1	0.7	0.2	-0.2	0.3	0.3	0.2	-0.2	0.3	0.0	-0.5	-0.2
Distance traveled before self-admin	0.3	0.5	1.2	-0.4	0.7	-0.7	-0.5	-0.5	-1.0	0.9	0.6	1.1	0.8	-0.1	0.6	-0.7	-0.2
Distance traveled after self-admin	1.7	2.1	4.6	1.1	-0.9	0.9	1.1	1.4	1.1	-1.9	-1.7	-1.8	-1.0	1.0	-1.8	1.7	-2.1
Extensor digitorum longus weight	1.3	5.1	8.5	2.6	-2.9	2.9	2.7	2.3	2.7	-1.9	-0.6	-2.0	-2.6	-1.8	-1.8	2.2	-1.4
Bone: elastic displacement	1.7	2.0	5.6	1.3	-1.8	1.8	1.7	1.2	1.8	-0.5	1.1	-0.7	-1.8	-2.4	-0.1	1.2	0.4
Bone: elastic work	1.0	1.3	6.3	-0.7	-0.2	0.2	0.1	-0.8	0.4	1.1	2.3	0.9	-0.2	-2.5	1.1	-0.1	1.0
Bone: endosteal estimation	1.8	4.0	15.2	-1.9	2.2	-2.2	-2.2	-1.4	-1.8	-0.6	-2.8	-0.3	2.0	3.9	-1.1	-0.4	-2.0
Bone: endosteal perimeter	4.6	9.7	19.0	-3.9	4.2	-4.1	-3.8	-3.3	-3.8	1.2	-1.6	1.6	3.7	4.4	0.5	-2.3	-0.6
Epididymis fat weight	0.1	0.3	1.3	-0.1	-0.4	0.4	0.4	-0.5	0.6	0.0	0.4	-0.2	-0.6	-1.1	0.6	-0.1	-0.5
Delta time in closed arm before/after self-admin	0.5	0.5	3.7	0.2	0.3	-0.3	-0.1	0.1	-0.2	-0.4	-1.1	-0.3	0.2	1.9	-0.5	-0.5	-0.8
Delta time in open arm before/after self-admin	0.8	0.8	1.4	1.1	-1.0	1.0	1.2	1.2	1.0	-0.7	-0.2	-0.8	-0.9	-0.3	-0.7	1.1	-0.8
Diff in mean of infusions in LGA sessions	0.8	1.0	3.5	-1.1	0.9	-0.8	-0.3	-1.2	-0.9	-0.2	-1.2	-0.0	-0.7	1.9	-1.1	-0.2	-1.6
Delay discount exponential model param	1.5	1.7	3.6	1.2	-1.7	1.7	1.3	1.1	1.9	-1.1	0.0	-1.2	-1.1	-1.7	-0.9	1.3	-0.4
Extinction: sum of active levers before priming	0.2	0.3	1.3	0.0	-0.4	0.4	0.2	0.3	0.6	-0.5	-0.0	-0.6	-0.5	-0.6	0.2	1.1	-0.5
Active lever presses in extinction session 6	0.5	0.5	2.2	0.1	-0.4	0.4	1.0	-0.1	0.3	-0.5	-0.5	-0.5	-1.5	-0.7	-0.9	0.1	-1.0
Bone: final force	1.5	2.4	4.4	-1.6	1.1	-1.1	-1.3	-1.8	-1.0	1.8	2.1	1.7	1.2	-1.3	1.4	-1.6	2.1
Bone: final moment	1.6	2.6	5.0	-1.8	1.2	-1.2	-1.4	-1.9	-1.0	1.8	2.1	1.7	1.3	-1.3	1.4	-1.5	2.2
Food consumed during 24 hour testing period	0.4	0.6	3.5	-0.1	0.8	-0.8	-0.5	0.0	-0.8	-0.2	-1.1	0.1	0.6	1.9	-0.4	-0.6	-0.1
Glucose	0.5	0.8	3.1	-0.9	0.2	-0.2	-0.5	-0.9	-0.1	1.1	1.8	1.0	0.5	-1.6	0.7	-0.6	0.5
Heart weight	1.3	2.1	9.2	-1.0	0.0	-0.1	-0.7	-1.1	0.2	1.5	2.8	1.1	0.3	-3.0	1.8	-0.5	1.4
Delay discount hyperbolic model param	1.4	1.6	3.6	1.1	-1.7	1.7	1.3	1.1	1.9	-1.2	-0.1	-1.3	-1.0	-1.6	-0.9	1.3	-0.4
Intermittent access intake day 1-15 change	0.3	0.7	1.9	-0.6	0.8	-0.8	-1.0	-0.4	-0.8	0.8	0.7	0.8	1.4	0.3	1.1	-0.6	1.0
Intermittent access intake escalation	0.3	0.6	1.8	-0.4	0.5	-0.5	-0.9	-0.2	-0.5	0.7	0.8	0.7	1.2	-0.1	1.2	-0.5	1.3
Intermittent access intake escalation 2	0.4	0.5	1.3	-0.3	0.5	-0.5	-0.7	-0.4	-0.6	0.7	0.4	0.5	1.0	0.1	0.9	-1.0	1.1
Intermitt. access day 1 inactive lever presses	0.1	0.4	1.1	-1.1	0.9	-0.9	-1.0	-0.5	-0.9	0.1	-0.0	0.5	0.8	0.1	-0.3	0.4	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.7	0.4	-0.1	0.1	-0.1	0.6	0.3	-0.7	-0.9	-0.6	0.3	0.1	-0.6	0.3	0.3
Intermitt. access escalation Index	0.4	0.5	3.1	-0.5	0.7	-0.7	-0.8	-0.1	-0.8	0.1	-0.4	0.2	1.1	1.8	-0.4	-0.2	-0.5
Intermittent access day 1 total infusions	0.5	0.7	2.7	-0.1	-0.7	0.7	0.8	0.0	0.9	-0.5	0.3	-0.4	-1.3	-1.6	-0.7	1.2	-1.0
Intermittent access day 15 total infusions	0.1	0.2	0.5	0.2	-0.4	0.4	0.4	0.3	0.6	-0.2	0.3	-0.2	-0.5	-0.7	-0.0	0.6	0.1
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.2	-0.4	0.0	0.1	0.2	0.1	-0.1	-0.5	0.1	0.2	-0.0
Intermittent access total infusions	0.2	0.2	1.2	-0.5	-0.1	0.1	0.1	-0.3	0.4	-0.1	0.3	-0.1	-0.6	-1.1	-0.4	0.6	-0.2
Intermittent access day 1 locomotion	1.1	1.3	4.3	0.8	-1.1	1.1	1.7	0.7	1.1	-1.1	-0.7	-1.1	-2.1	-0.8	-0.9	0.8	-1.2
Intermittent access day 15 total locomotion	0.2	0.3	2.0	-0.0	-0.3	0.3	0.7	-0.1	0.2	0.0	0.4	-0.0	-0.9	-1.4	0.4	0.0	-0.4
Intermittent access total locomotion	0.4	0.4	1.6	0.1	-0.6	0.6	0.9	0.1	0.7	-0.5	-0.0	-0.5	-1.3	-1.3	-0.3	0.3	-0.4
Intermittent access standard deviation	2.6	5.4	9.7	-3.1	2.5	-2.5	-2.8	-2.9	-2.2	2.5	2.2	2.5	2.3	-0.5	1.8	-2.1	1.5
Left kidney weight	1.0	4.7	7.9	-2.5	2.1	-2.1	-1.9	-2.8	-1.8	2.7	2.5	2.4	1.7	-0.9	2.2	-2.5	1.4
Right kidney weight	0.4	1.8	4.6	-1.2	0.7	-0.7	-0.4	-1.5	-0.6	1.7	2.1	1.4	0.3	-1.8	2.0	-1.4	0.9
Cocaine induced anxiety	1.1	1.6	6.0	-0.6	0.9	-0.9	-1.4	-0.7	-0.7	1.3	1.3	1.0	1.5	-0.3	1.4	-1.6	2.4
Post-drug Anxiety	0.5	0.6	2.3	0.1	-0.1	0.1	-0.5	-0.0	0.1	0.8	1.3	0.4	0.2	-1.1	1.1	-0.5	1.5
Baseline Anxiety	1.0	1.2	3.0	0.6	-0.9	1.0	1.2	0.7	0.8	-1.0	-0.9	-1.0	-1.7	0.1	-0.8	1.4	-1.7
Tail length	0.2	0.8	3.4	0.2	0.9	-0.9	0.1	-0.2	-1.2	0.4	-0.7	0.5	0.5	1.6	0.8	-1.8	-0.5
Length with tail	1.1	5.0	13.2	-2.0	2.5	-2.6	-1.8	-2.6	-2.5	2.6	1.3	2.5	1.8	0.5	1.9	-3.6	1.1
Length without tail	1.8	5.7	10.3	-2.8	2.2	-2.2	-2.0	-3.2	-2.0	3.1	2.7	2.9	1.5	-1.3	2.0	-2.7	1.5
Times rat made contact with spout	0.2	0.3	0.8	0.5	-0.2	0.2	0.4	0.6	0.1	-0.7	-0.9	-0.6	-0.3	0.7	-0.6	0.4	-0.5
Lifetime Intake	0.2	0.2	1.7	-0.6	-0.0	0.0	-0.0	-0.4	0.5	-0.1	0.3	-0.1	-0.6	-1.3	-0.2	0.5	-0.1
Liver weight, left	1.1	1.8	3.7	-1.8	1.5	-1.5	-1.9	-1.6	-1.1	1.3	0.9	1.2	1.5	-0.2	1.0	-1.0	1.3
Liver weight, right	1.0	1.7	3.1	-1.6	1.8	-1.8	-1.5	-1.4	-1.7	1.1	0.2	1.3	1.4	0.8	1.2	-1.2	0.4
Locomotor activity	0.0	0.1	0.4	0.2	-0.3	0.2	0.2	0.1	0.2	-0.2	-0.3	-0.2	-0.5	-0.0	0.1	0.1	0.6
Locomotor testing distance	0.2	0.3	1.5	0.0	-0.2	0.2	0.3	-0.1	0.2	-0.7	-1.2	-0.7	-0.5	0.8	-0.7	0.2	-0.2
Locomotor testing rearing	0.6	1.1	3.2	1.2	-0.8	0.8	0.8	1.3	0.7	-1.4	-1.8	-1.3	-0.7	1.0	-1.1	0.8	-0.0
Locomotion in novel chamber	1.0	1.3	6.2	0.6	-0.1	0.1	0.5	0.7	-0.0	-1.2	-2.3	-1.0	-0.8	2.5	-1.3	0.3	-1.1
Locomotion in novel chamber post-restriction	0.6	1.0	4.4	-0.9	1.0	-1.0	-0.6	-0.6	-0.9	-0.4	-1.5	-0.0	0.5	2.1	-1.4	-0.6	-0.5
Fecal boli incidents, locomotor time 1	0.4	0.6	1.4	0.3	-0.7	0.7	0.5	0.4	0.9	-1.1	-0.8	-1.0	-0.9	-0.2	-1.2	0.9	-0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	0.1	-0.4	0.4	0.2	0.1	0.3	-0.0	0.4	0.0	-0.6	-0.6	-0.2	0.5	-0.1
Time >=10cm from walls, locomotor time 1	0.5	0.5	3.2	-0.3	0.7	-0.6	-0.5	-0.1	-0.7	-0.3	-1.0	-0.0	0.7	1.8	-0.5	-0.4	-0.2
Bouts of movement, locomotor time 1	0.3	0.3	1.3	0.3	-0.6	0.5	0.1	0.5	0.6	0.0	0.6	-0.1	-0.5	-1.2	0.4	0.6	0.3
Total resting periods, locomotor time 1	0.4	0.4	1.3	0.4	-0.8	0.8	0.4	0.6	0.8	-0.2	0.5	-0.2	-0.7	-1.1	0.1	0.9	0.0
Rest time, locomotor task time 1	0.4	0.6	2.7	-0.7	-0.0	0.0	-0.4	-0.5	0.2	0.7	1.3	0.5	-0.2	-1.6	1.1	0.5	0.3
Distance moved, locomotor task time 1	0.2	0.2	1.3	0.5	0.1	-0.1	0.4	0.3	-0.3	-0.3	-0.8	-0.2	0.2	1.2	-0.5	-0.2	-0.6
Vertical activity count, locomotor time 1	0.3	0.7	1.9	1.4	-0.5	0.5	0.8	1.3	0.3	-1.0	-1.4	-1.0	-0.2	0.8	-0.3	0.4	-0.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	0.5	-0.4	0.4	0.6	0.4	0.4	-0.1	0.1	-0.2	-0.5	-0.6	0.3	0.2	0.6
Bouts of movement, locomotor time 2	0.1	0.1	0.7	-0.5	0.4	-0.3	-0.2	-0.4	-0.3	-0.0	-0.1	0.1	0.2	0.3	0.2	-0.1	-0.8
Total resting periods, locomotor time 2	0.1	0.2	0.8	-0.6	0.4	-0.4	-0.3	-0.4	-0.3	-0.1	-0.3	-0.0	0.2	0.6	0.3	-0.1	-0.9
Rest time, locomotor task time 2	0.4	0.5	1.6	-1.1	0.8	-0.8	-1.3	-0.9	-0.7	0.1	-0.4	0.2	0.7	0.6	0.6	-0.2	-0.2
Distance moved, locomotor task time 2	0.4	0.5	1.4	0.7	-0.6	0.5	1.0	0.5	0.4	0.4	1.0	0.2	-0.7	-1.2	0.9	0.4	0.4
Vertical activity count, locomotor time 2	0.3	0.3	1.7	0.7	-0.5	0.5	0.8	0.5	0.4	0.0	0.6	-0.1	-0.4	-1.3	0.7	0.4	-0.2
Light reinforcement 1	1.3	3.2	6.7	2.6	-2.1	2.1	1.8	2.4	1.9	-1.8	-1.2	-1.8	-1.7	-0.5	-1.4	1.7	-0.9
Light reinforcement 2	0.1	0.1	0.7	0.8	-0.3	0.3	0.2	0.5	0.3	0.1	0.2	-0.0	-0.1	0.0	0.4	-0.1	0.2
Bone: marrow area	1.8	4.0	15.1	-1.9	2.2	-2.2	-2.2	-1.4	-1.8	-0.6	-2.8	-0.2	2.0	3.9	-1.1	-0.4	-1.9
Bone: maximum diameter	5.8	10.8	20.0	-4.5	4.1	-4.1	-4.1	-4.1	-3.7	2.8	1.2	2.9	3.8	1.7	2.3	-2.9	1.0
Bone: maximum force	1.1	1.9	3.8	-1.8	1.2	-1.2	-1.3	-1.9	-0.9	1.5	1.7	1.4	1.2	-1.1	0.9	-1.3	1.4
Bone: maximum moment	1.2	2.0	4.0	-2.0	1.2	-1.2	-1.4	-2.0	-0.9	1.5	1.7	1.4	1.2	-1.1	0.9	-1.3	1.6
Mean time between licks in bursts	0.0	0.1	0.2	-0.3	0.0	-0.0	-0.1	-0.2	0.1	0.2	0.5	0.1	0.4	-0.1	0.3	-0.0	0.5
Mean num. licks in bursts	0.5	0.8	1.6	0.8	-0.7	0.7	0.6	0.9	0.8	-1.1	-0.9	-1.0	-0.9	0.5	-1.3	1.0	-0.5
Cd content in liver	2.0	2.2	4.4	1.3	-1.7	1.7	1.4	1.4	1.9	-1.3	-0.4	-1.4	-1.9	-1.3	-1.2	2.1	-0.7
Co content in liver	0.1	0.1	0.4	-0.0	-0.1	0.1	-0.1	0.2	0.4	-0.3	0.1	-0.2	-0.4	-0.4	-0.4	0.6	0.4
Cu content in liver	0.1	0.1	0.2	-0.3	0.4	-0.4	-0.4	-0.3	-0.4	0.3	0.2	0.2	0.3	0.0	0.3	-0.1	0.4
Fe content in liver	0.6	0.7	4.4	-0.3	0.8	-0.8	-0.5	0.0	-0.7	-0.6	-1.5	-0.4	0.3	2.1	-0.5	-0.0	-0.7
K content in liver	0.2	0.2	0.7	0.4	-0.1	0.0	0.0	0.5	0.1	-0.5	-0.8	-0.4	-0.1	0.8	-0.8	-0.0	0.7
Mg content in liver	2.0	2.0	3.1	1.6	-1.4	1.3	1.6	1.6	1.3	-1.8	-1.7	-1.7	-1.4	0.7	-1.6	1.1	-0.5
Mn content in liver	0.3	0.4	1.1	-0.5	0.6	-0.6	-0.6	-0.5	-0.5	0.5	0.2	0.4	0.6	0.4	0.5	-1.0	1.1
Na content in liver	0.2	0.3	0.9	-0.4	0.6	-0.6	-0.5	-0.2	-0.4	-0.2	-0.7	-0.1	0.4	1.0	-0.2	-0.3	0.8
Rb content in liver	1.1	1.2	2.2	1.4	-1.3	1.3	1.5	1.3	1.1	-1.2	-0.8	-1.3	-1.0	-0.2	-0.7	1.1	-0.6
Se content in liver	0.7	0.8	2.7	1.0	-0.4	0.4	0.8	1.1	0.2	-1.1	-1.6	-1.1	-0.6	1.4	-0.7	0.4	-0.4
Sr content in liver	0.2	0.2	1.0	0.1	-0.5	0.5	0.3	0.1	0.6	0.1	0.5	-0.1	-0.4	-1.0	0.1	0.4	0.5
Zn content in liver	0.1	0.1	0.2	-0.3	0.2	-0.2	-0.3	-0.2	-0.1	0.2	0.4	0.3	0.2	-0.4	0.3	0.2	0.1
Bone: minimum diameter	2.1	3.9	7.5	-2.7	2.7	-2.7	-2.4	-2.4	-2.4	1.4	-0.0	1.6	2.2	1.8	0.9	-1.5	0.1
Time in familiar zone, hab. session 1	0.1	0.1	0.4	0.4	-0.3	0.3	0.0	0.6	0.3	-0.3	0.1	-0.2	-0.2	-0.3	-0.6	0.5	-0.1
Time in novel zone, hab. session 1	0.6	0.6	1.1	-0.7	0.9	-0.9	-0.8	-0.7	-0.9	0.7	0.1	0.6	0.8	0.6	1.1	-1.0	0.7
Total zone transitions, hab. session 1	1.4	1.9	3.2	1.7	-1.7	1.7	1.8	1.4	1.6	-1.5	-0.9	-1.5	-1.4	-0.1	-1.4	0.9	0.0
Total locomotion distance, hab. session 1	1.3	1.8	3.0	1.7	-1.7	1.7	1.7	1.5	1.6	-1.3	-0.7	-1.3	-1.4	-0.6	-1.1	1.0	-0.5
Locomotion velocity, hab. session 1	1.9	2.6	4.6	2.0	-2.1	2.1	2.1	1.7	2.0	-1.5	-0.7	-1.6	-1.6	-0.8	-1.3	1.3	-0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.4	0.2	-0.3	0.3	0.0	0.2	0.4	-0.3	-0.0	-0.3	-0.6	-0.6	-0.4	0.4	0.1
Time in novel zone, hab. session 2	0.3	0.3	0.8	-0.8	0.7	-0.7	-0.4	-0.6	-0.7	0.4	0.1	0.4	0.9	0.8	0.4	-0.4	-0.1
Total zone transitions, hab. session 2	5.2	6.7	9.3	2.9	-3.1	3.1	3.0	2.6	3.0	-2.8	-1.8	-2.8	-3.0	-0.3	-2.7	2.2	-1.0
Total locomotion distance, hab. session 2	5.3	6.9	10.8	3.0	-3.3	3.3	3.1	2.8	3.2	-2.6	-1.3	-2.7	-2.9	-1.2	-2.4	2.3	-1.3
Locomotion velocity, hab. session 2	5.0	6.7	10.6	3.1	-3.3	3.2	3.1	2.8	3.2	-2.5	-1.3	-2.6	-2.8	-1.2	-2.3	2.2	-1.1
Novel to familiar place preference ratio	2.3	2.6	3.6	1.4	-1.6	1.7	1.7	1.5	1.7	-1.9	-1.4	-1.9	-1.8	0.0	-1.7	1.9	-1.3
Novelty place preference	1.8	1.9	2.9	1.2	-1.3	1.4	1.5	1.3	1.4	-1.7	-1.4	-1.6	-1.5	0.2	-1.6	1.6	-1.2
Time in novel zone, NPP test	2.2	2.3	3.4	1.3	-1.5	1.6	1.6	1.4	1.6	-1.8	-1.4	-1.8	-1.7	0.1	-1.7	1.8	-1.2
Total zone transitions, NPP test	2.9	4.2	7.3	2.7	-2.5	2.4	2.4	2.3	2.5	-2.1	-1.3	-2.2	-2.2	-0.5	-2.1	1.6	-0.4
Total locomotion distance, NPP test	6.6	9.0	14.5	3.7	-3.8	3.8	3.6	3.3	3.6	-2.8	-1.1	-2.8	-3.1	-1.8	-2.8	2.6	-1.4
Locomotion velocity, NPP test	5.5	7.7	12.4	3.5	-3.5	3.5	3.3	3.1	3.4	-2.6	-1.1	-2.6	-2.9	-1.6	-2.6	2.3	-1.3
Intraocular pressure	1.5	2.1	8.1	0.7	-0.7	0.8	1.1	0.8	0.7	-1.7	-2.2	-1.5	-1.3	0.7	-1.6	1.6	-2.9
Delta distance traveled before/after self-admin	2.1	2.2	4.3	1.2	-1.4	1.4	1.4	1.5	1.7	-1.9	-1.4	-2.1	-1.4	0.4	-1.5	1.8	-0.9
Delta ambulatory time before/after self-admin	2.2	2.7	5.4	1.3	-1.4	1.4	1.5	1.6	1.9	-2.2	-1.8	-2.3	-1.5	0.8	-1.8	2.0	-1.0
Parametrial fat weight	0.1	0.2	0.7	0.0	-0.1	0.1	0.2	0.2	0.3	-0.3	-0.5	-0.3	-0.4	-0.3	-0.3	0.6	-0.9
Pavlov. Cond. lever latency	0.8	1.0	3.4	0.2	-0.1	0.1	0.4	0.4	0.2	-1.2	-1.8	-1.1	-0.5	1.5	-1.1	0.7	-1.7
Pavlov. Cond. magazine entry latency	2.5	3.2	4.8	-1.9	2.2	-2.2	-2.1	-1.8	-2.0	1.7	0.8	1.8	2.0	0.7	1.7	-1.8	1.4
Pavlov. Cond. change in total contacts	0.7	0.7	2.4	0.5	-1.1	1.1	0.8	0.5	1.2	-0.3	0.7	-0.4	-1.0	-1.5	-0.3	0.7	0.5
Pavlov. Cond. index score	1.2	1.6	2.3	-1.2	1.2	-1.3	-1.3	-1.2	-1.1	1.5	1.3	1.4	1.3	-0.3	1.3	-1.3	1.3
Pavlov. Cond. latency score	1.7	2.2	3.4	-1.3	1.4	-1.4	-1.5	-1.3	-1.3	1.8	1.7	1.8	1.5	-0.5	1.6	-1.6	1.5
Pavlov. Cond. lever contacts	0.3	0.4	2.0	0.0	-0.2	0.2	-0.1	-0.0	0.2	0.7	1.4	0.6	0.1	-1.3	0.4	-0.1	0.9
Pavlov. Cond. magazine entry number	2.4	3.1	4.1	2.0	-2.0	2.0	2.0	1.9	1.8	-1.8	-1.2	-1.8	-2.0	-0.2	-1.7	1.8	-1.4
Pavlov. Cond. intertrial magazine entries	1.9	2.3	3.5	1.6	-1.6	1.6	1.6	1.7	1.4	-1.8	-1.5	-1.7	-1.5	0.3	-1.9	1.5	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.8	1.0	1.5	-0.9	1.0	-1.0	-1.0	-0.9	-0.8	1.2	1.1	1.2	1.0	-0.3	1.1	-1.0	1.2
Pavlov. Cond. response bias	1.3	1.6	2.1	-1.4	1.3	-1.3	-1.4	-1.3	-1.1	1.4	1.2	1.4	1.3	-0.4	1.3	-1.2	1.4
Pavlov. Cond. lever latency	1.2	1.6	5.5	-0.9	0.5	-0.6	-0.6	-1.0	-0.6	1.7	2.4	1.5	0.5	-1.6	1.8	-1.0	1.2
Pavlov. Cond. magazine entry latency	0.8	1.0	2.3	0.4	-0.9	0.9	0.6	0.6	1.0	-1.1	-0.7	-1.0	-0.7	-0.4	-1.5	1.5	-1.3
Pavlov. Cond. change in total contacts	1.3	2.1	4.1	1.1	-1.3	1.3	1.1	1.3	1.2	-1.9	-1.8	-1.6	-1.1	0.3	-2.0	1.7	-1.6
Pavlov. Cond. index score	1.1	1.4	3.5	0.8	-0.9	0.9	0.7	1.0	1.0	-1.6	-1.7	-1.4	-0.7	0.5	-1.9	1.5	-1.4
Pavlov. Cond. latency score	0.8	1.1	2.9	0.5	-0.6	0.6	0.4	0.7	0.7	-1.4	-1.6	-1.1	-0.5	0.7	-1.7	1.2	-1.3
Pavlov. Cond. lever contacts	1.6	2.3	6.0	1.3	-0.9	1.0	1.0	1.4	0.9	-2.0	-2.4	-1.7	-0.8	1.5	-2.1	1.3	-1.5
Pavlov. Cond. magazine entry number	1.0	1.2	2.7	-0.6	0.9	-0.9	-0.7	-0.9	-1.0	1.3	1.0	1.1	0.8	0.2	1.6	-1.5	1.6
Pavlov. Cond. intertrial magazine entries	0.7	1.0	7.5	0.4	0.7	-0.8	0.0	0.2	-0.8	-0.5	-1.9	-0.4	0.2	2.7	-0.2	-0.9	-0.6
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	3.6	0.7	-0.8	0.9	0.6	0.9	0.9	-1.6	-1.7	-1.3	-0.6	0.6	-1.9	1.4	-1.4
Pavlov. Cond. response bias	1.6	2.2	4.2	1.3	-1.3	1.3	1.2	1.4	1.3	-1.9	-1.7	-1.7	-1.1	0.5	-2.1	1.7	-1.6
Time in closed arm before self-admin	0.6	0.8	4.6	-0.1	-0.3	0.3	0.2	-0.3	0.1	0.8	1.6	0.6	-0.1	-2.1	1.1	-0.1	1.0
Time in closed arm after self-admin	0.6	0.7	2.3	-1.2	0.8	-0.8	-0.8	-1.0	-0.5	0.7	1.0	0.5	0.5	-0.4	1.5	-0.5	0.3
Time in open arm before self-admin	0.2	0.2	0.5	-0.2	0.4	-0.4	-0.3	-0.3	-0.4	0.0	-0.6	0.1	0.1	0.5	-0.3	-0.7	0.5
Time in open arm after self-admin	1.1	1.2	4.0	1.0	-0.8	0.8	1.1	1.0	0.8	-1.1	-1.2	-1.0	-0.9	0.6	-2.0	0.9	-1.1
Bone: periosteal estimation	1.8	3.8	8.1	-2.8	2.6	-2.5	-2.7	-2.6	-2.1	1.3	0.2	1.5	2.4	1.3	0.9	-1.4	-0.1
Bone: periosteal perimeter	5.5	9.4	15.7	-4.0	3.6	-3.6	-3.5	-3.8	-3.3	3.1	2.1	3.2	3.2	0.5	2.5	-2.9	1.5
Bone: post-yield work	0.5	0.8	2.4	0.4	-0.7	0.7	0.9	0.4	0.8	-1.1	-0.9	-1.1	-0.9	0.0	-1.5	0.8	-0.8
Progressive ratio test 1 active lever presses	0.4	0.5	0.8	0.3	-0.6	0.6	0.7	0.4	0.9	-0.8	-0.6	-0.8	-0.8	-0.3	-0.8	0.8	-0.9
Progressive ratio test 1 breakpoint	0.4	0.5	0.8	0.3	-0.6	0.6	0.7	0.4	0.9	-0.8	-0.6	-0.8	-0.8	-0.2	-0.9	0.8	-0.9
Progressive ratio test 1 inactive lever presses	0.1	0.1	0.5	-0.3	0.3	-0.3	-0.2	-0.0	-0.2	-0.2	-0.4	0.0	0.1	-0.1	-0.7	0.3	0.0
Progressive ratio test 2 active lever presses	0.9	1.0	2.1	0.6	-1.0	1.0	1.4	0.6	1.2	-0.8	-0.3	-0.9	-1.4	-1.2	-0.4	1.1	-1.2
Progressive ratio test 2 breakpoint	0.7	0.8	1.7	0.5	-1.0	1.0	1.3	0.5	1.1	-0.7	-0.1	-0.7	-1.3	-1.3	-0.3	1.0	-1.1
Progressive ratio test 2 inactive lever presses	0.1	0.2	1.4	-0.1	-0.2	0.2	0.3	-0.0	0.2	0.2	0.5	0.2	-0.2	-1.2	0.6	0.4	-0.1
Incentive Sensitization - Responses	0.2	0.3	2.1	-0.5	0.2	-0.2	0.2	-0.5	-0.1	0.5	0.7	0.5	-0.3	-1.5	0.8	0.2	-0.3
Incentive Sensitization - Breakpoint	0.3	0.4	2.2	-0.7	0.3	-0.3	0.1	-0.5	-0.2	0.6	0.8	0.6	-0.2	-1.5	0.9	0.2	-0.2
Sum of active levers in priming session hrs 5-6	0.3	0.3	1.2	-0.2	-0.3	0.4	0.1	-0.1	0.3	-0.5	-0.3	-0.3	-0.7	-0.2	-1.0	1.1	-0.7
Progressive ratio	0.4	0.6	2.5	-0.1	-0.6	0.6	0.8	0.1	0.7	-0.5	-0.0	-0.4	-1.6	-1.0	-0.7	1.2	-1.2
Food seeking constrained by brief footshock	0.5	0.7	1.7	-1.0	0.7	-0.7	-0.9	-0.9	-0.7	1.0	1.3	1.0	0.6	-0.8	0.6	-0.3	0.4
Seeking ratio, punishment vs. effort	0.6	0.8	2.8	-0.5	0.9	-0.9	-1.2	-0.5	-0.9	0.8	0.6	0.8	1.7	0.6	0.8	-1.0	1.1
Retroperitoneal fat weight	0.1	0.4	1.9	-0.1	0.6	-0.6	-0.2	-0.2	-0.6	-0.4	-1.4	-0.3	0.3	0.9	0.3	-0.5	-0.9
Reaction time number correct	2.1	4.0	7.3	2.3	-1.9	1.9	1.5	2.2	1.8	-2.4	-2.7	-2.4	-1.4	1.2	-2.5	1.9	-1.2
Reaction time mean minus median	0.4	1.0	2.7	-0.6	0.6	-0.6	-1.0	-0.6	-0.5	1.1	1.4	0.9	0.7	-1.2	1.6	-0.5	1.5
Reaction time mean minus median AUC	0.7	1.7	4.7	-1.0	1.2	-1.2	-1.7	-1.0	-1.1	1.4	1.1	1.3	1.4	-0.3	1.6	-1.2	2.2
Reaction time num false alarms	0.2	0.3	3.2	0.2	-0.2	0.2	0.6	0.2	-0.1	-0.2	-0.2	-0.1	-0.6	0.1	0.0	0.4	-1.8
Reaction time num false alarms AUC	0.3	0.5	4.1	0.5	-0.4	0.4	0.9	0.4	0.1	-0.6	-0.6	-0.4	-0.8	0.2	-0.4	0.4	-2.0
Reaction time trials correct on left	2.1	4.0	7.3	2.3	-1.9	1.9	1.5	2.2	1.8	-2.4	-2.7	-2.4	-1.4	1.2	-2.5	1.9	-1.2
Reaction time trials on left	2.1	3.9	7.3	2.3	-1.8	1.9	1.5	2.2	1.8	-2.4	-2.7	-2.4	-1.3	1.2	-2.5	1.8	-1.2
Reaction time mean	0.1	0.1	0.5	-0.2	0.0	-0.0	-0.4	-0.1	0.1	0.1	0.3	-0.0	0.2	-0.5	0.7	0.3	0.7
Reaction time mean AUC	0.1	0.1	0.6	0.0	-0.3	0.2	-0.2	0.1	0.4	-0.0	0.3	-0.2	-0.0	-0.8	0.5	0.4	0.6
Median of all reaction times	0.0	0.1	0.2	-0.2	-0.1	0.1	-0.3	-0.0	0.1	-0.0	0.0	-0.2	0.2	-0.2	0.5	0.3	0.5
Reaction time omissions	1.1	1.6	3.0	-1.1	1.3	-1.4	-1.7	-1.2	-1.2	1.4	0.9	1.3	1.6	-0.0	1.4	-1.2	1.2
Reaction time false alarm rate	0.4	0.5	1.2	-0.7	0.6	-0.6	0.0	-0.7	-0.8	0.7	0.8	0.8	-0.0	-0.3	1.0	-0.5	-1.1
Reaction time premature initiation rate	2.9	4.0	7.2	2.2	-2.7	2.7	2.5	1.9	2.6	-1.8	-0.3	-2.0	-2.4	-1.6	-1.3	1.7	-0.3
Reaction time premature initiations	4.4	7.8	11.5	3.1	-3.4	3.4	3.1	2.9	3.3	-3.0	-1.9	-3.2	-2.9	-0.6	-2.7	2.7	-1.2
Std. dev. reaction times	0.2	0.3	1.1	-0.2	0.0	-0.0	-0.5	-0.1	0.1	0.3	0.7	0.2	0.3	-1.1	0.8	0.2	1.0
Reaction time trials completed	2.1	3.9	7.3	2.3	-1.8	1.9	1.5	2.2	1.8	-2.4	-2.7	-2.4	-1.3	1.2	-2.5	1.8	-1.2
Reaction time trials AUC	2.5	4.8	7.9	2.5	-2.1	2.1	1.8	2.4	2.0	-2.6	-2.8	-2.6	-1.6	1.1	-2.7	2.0	-1.4
Run reversals in cocaine runway, females	0.2	0.2	0.7	-0.3	0.3	-0.2	-0.1	-0.2	-0.6	0.2	0.0	0.6	0.1	-0.2	-0.8	-0.4	-0.9
Run reversals in cocaine runway, males	0.3	0.3	2.3	0.0	-0.4	0.4	-0.0	-0.3	0.5	0.3	0.9	0.1	-0.3	-1.5	-0.3	-0.3	0.9
Latency to leave start box in cocaine runway	0.6	0.7	1.3	0.6	-1.0	1.0	1.1	0.4	1.0	-0.5	-0.0	-0.4	-1.1	-0.8	-0.9	0.5	-1.0
Latency to leave start box in cocaine runway, F	0.7	0.8	1.2	1.0	-1.1	1.1	1.1	0.8	1.1	-0.8	-0.5	-0.8	-1.0	-0.3	-1.1	0.5	-1.0
Latency to leave start box in cocaine runway, M	0.4	0.3	1.0	0.1	-0.7	0.7	0.7	0.0	0.6	-0.3	0.3	-0.2	-0.9	-1.0	-0.4	0.6	-0.7
Std. dev. time between licks in bursts	1.2	1.6	3.3	1.4	-0.9	0.9	1.2	1.6	1.0	-1.6	-1.8	-1.6	-1.3	1.1	-1.1	1.1	-0.8
Total sessions with >9 infusions	0.5	0.6	2.5	-1.6	0.7	-0.7	-0.9	-1.2	-0.1	0.3	0.5	0.4	0.1	-1.5	0.2	0.1	0.0
Short access day 1 total inactive lever presses	1.0	1.3	3.0	-1.7	1.4	-1.4	-1.3	-1.6	-1.2	1.0	0.3	1.1	0.6	-0.5	1.0	-0.9	1.1
Short access day 10 total inactive lever presses	0.5	1.3	2.8	-0.9	1.4	-1.4	-1.5	-0.7	-1.6	0.7	-0.4	1.0	1.7	1.4	0.1	-0.9	1.2
Short access day 1 total infusions	0.4	0.5	2.3	-1.5	0.8	-0.8	-0.6	-1.2	-0.2	0.3	0.4	0.5	-0.1	-1.2	0.3	-0.1	-0.0
Short access day 10 total infusions	0.5	0.6	2.7	-1.6	1.0	-1.0	-0.8	-1.2	-0.5	0.0	-0.4	0.3	0.1	0.0	-0.6	0.2	-0.9
Short access total infusions	0.2	0.3	1.3	-1.1	0.3	-0.3	-0.3	-0.7	0.3	-0.1	0.1	0.1	-0.5	-1.2	-0.1	0.6	-0.5
Short access day 1 locomotion	0.3	0.4	1.1	-1.0	0.4	-0.4	-0.4	-1.0	-0.1	0.4	0.6	0.5	0.0	-1.1	0.3	-0.5	0.7
Short access day 10 total locomotion	0.2	0.3	1.2	-1.1	0.7	-0.7	-0.5	-1.0	-0.7	0.5	0.4	0.5	-0.1	-0.5	0.3	-0.4	-0.2
Short access total locomotion	0.9	1.1	2.7	-1.7	0.9	-0.9	-0.9	-1.5	-0.6	0.9	1.1	0.9	0.2	-1.4	1.0	-0.8	0.7
One hour access (0.3 mA shock)	0.8	0.9	2.2	0.5	-1.0	1.0	1.0	0.7	1.2	-1.0	-0.3	-1.0	-1.5	-1.0	-0.2	1.2	-1.0
Compulsive drug intake	0.2	0.2	0.5	0.6	-0.4	0.4	0.6	0.6	0.3	-0.6	-0.7	-0.5	-0.3	-0.4	-0.5	-0.0	-0.4
One hour access (shock baseline)	0.0	0.1	0.3	-0.0	-0.2	0.2	0.2	0.1	0.4	-0.2	0.1	-0.3	-0.5	-0.2	0.1	0.5	-0.3
Social response proportion	0.3	0.3	1.1	0.6	-0.7	0.7	0.7	0.5	0.4	-0.2	0.3	-0.3	-0.7	-1.1	0.3	0.4	-0.5
Social responses	0.1	0.2	0.6	0.4	-0.5	0.4	0.3	0.3	0.2	0.2	0.6	0.1	-0.2	-0.7	0.1	-0.1	0.8
Social time	0.6	0.8	2.1	0.7	-1.0	1.0	1.1	0.7	0.9	-0.3	0.5	-0.3	-1.2	-1.5	-0.0	0.9	-0.8
Soleus weight	0.6	1.7	4.5	1.6	-1.8	1.8	1.4	1.3	1.6	-0.3	0.8	-0.6	-1.5	-2.1	-0.1	0.9	0.4
Bone: stiffness	1.3	2.1	3.3	-1.6	1.2	-1.2	-1.4	-1.8	-1.0	1.7	1.8	1.5	1.3	-1.0	1.2	-1.5	1.5
Tibialis anterior weight	0.3	0.9	2.1	0.7	-1.3	1.3	1.0	0.6	1.3	-0.4	0.5	-0.5	-1.1	-1.4	-0.5	0.9	0.2
Time to tail flick, vehicle, before self-admin	0.3	0.3	1.2	0.6	-0.5	0.4	0.2	0.6	0.5	-0.0	0.2	-0.3	-0.2	-1.0	-0.1	0.1	1.1
Time to tail flick, vehicle, after self-admin	0.8	1.1	3.5	-1.1	0.5	-0.5	-0.2	-1.1	-0.7	1.4	1.9	1.4	0.2	-1.5	0.9	-0.2	-0.8
Time to tail flick, test, before self-admin	0.6	0.6	1.5	1.0	-0.4	0.4	0.9	0.9	0.3	-0.8	-1.2	-0.8	-0.6	1.0	-0.9	0.1	-0.5
Time to tail flick, test, after self-admin	1.4	1.5	3.0	-1.4	1.3	-1.3	-0.9	-1.6	-1.5	1.5	0.8	1.6	0.6	-0.1	0.6	-1.7	0.1
Delta time to tail flick, vehicle, before/after SA	0.6	0.5	3.7	-0.9	0.7	-0.7	0.1	-0.7	-0.8	0.4	0.2	0.7	0.0	0.3	0.3	0.0	-1.9
Delta time to tail flick, test, before/after SA	2.5	2.5	4.2	-1.7	1.3	-1.3	-1.6	-1.9	-1.4	2.1	2.0	2.0	1.3	-1.0	1.5	-1.6	1.2
Tibia length	12.7	34.9	45.9	-6.1	6.4	-6.4	-6.4	-6.3	-6.4	6.8	5.1	6.6	6.2	0.5	5.9	-6.6	3.8
Ambulatory time before self-admin	0.8	1.1	2.7	-0.7	1.0	-1.0	-1.0	-0.8	-1.4	1.4	1.2	1.6	1.2	-0.4	1.0	-1.1	0.3
Ambulatory time after self-admin	0.8	0.9	1.7	0.7	-0.6	0.6	0.8	0.9	0.9	-1.3	-1.1	-1.2	-0.7	0.5	-1.3	1.2	-1.2
Bone: tissue strength	0.6	0.6	1.1	0.3	-0.8	0.8	0.9	0.4	1.1	-0.8	-0.3	-0.9	-0.9	-0.8	-1.0	1.0	-0.3
Total heroin consumption	1.2	1.5	3.8	-1.9	1.6	-1.5	-1.3	-1.8	-1.3	1.0	0.1	0.9	0.7	1.2	0.7	-0.8	-0.3
Bone: trabecular number	0.2	0.4	1.5	0.4	-0.1	0.1	0.4	0.6	0.0	-0.7	-1.2	-0.7	-0.3	1.1	-0.8	0.1	-0.2
Bone: trabecular spacing	0.1	0.2	0.8	-0.3	0.3	-0.3	-0.9	-0.4	-0.2	0.4	0.5	0.4	0.7	-0.2	0.2	-0.1	0.5
Bone: trabecular thickness	0.4	0.5	1.2	0.3	-0.4	0.4	1.0	0.5	0.5	-0.9	-1.1	-0.9	-0.9	0.4	-0.5	0.8	-1.0
Bone: trabecular tissue density	0.2	0.2	0.6	0.2	0.4	-0.4	-0.3	-0.1	-0.5	0.7	0.5	0.7	0.3	-0.3	0.8	-0.6	0.1
Water consumed over 24 hours	0.1	0.1	0.5	0.6	-0.2	0.2	0.5	0.7	0.1	-0.3	-0.3	-0.3	-0.3	0.2	-0.2	0.1	-0.1
Number of responses in last shaping day	1.1	1.2	2.4	-1.5	0.9	-0.8	-1.1	-1.5	-0.8	1.1	1.1	1.2	0.8	-1.2	0.9	-0.9	1.2