Hub : Genes

C1qc

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression C1qc 0.35 0.15 2.1e-11 0.2 0.19 0.21 0.2 8.8e-09 1.4e-08 4.1e-09 8.0e-09
2 pVTA gene expression C1qc 0.21 0.1 0.0e+00 0.26 0.25 0.26 0.26 1.4e-20 4.0e-20 1.1e-20 1.5e-20
3 LHb gene expression C1qc 0.33 0.21 1.3e-06 0.24 0.29 0.29 0.27 2.6e-06 1.0e-07 1.6e-07 4.1e-07
4 BLA gene expression C1qc 0.25 0.13 5.8e-11 0.2 0.19 0.2 0.2 1.2e-10 3.8e-10 1.1e-10 5.7e-11
5 PL gene expression C1qc 0.17 0.07 0.0e+00 0.25 0.25 0.25 0.25 3.0e-27 3.2e-27 1.7e-27 3.3e-27
6 RMTg gene expression C1qc 0.1 0.07 6.1e-03 0.06 0.04 0.06 0.04 1.2e-02 3.1e-02 1.1e-02 3.4e-02
7 Brain gene expression C1qc 0.36 0.14 0.0e+00 0.32 0.3 0.32 0.33 4.7e-30 7.2e-29 8.0e-31 6.5e-32
8 Adipose mRNA stability C1qc 0.02 0.02 5.1e-03 0.01 0 0 0 2.8e-02 1.0e-01 3.1e-01 1.2e-01
9 OFC gene expression C1qc 0.29 0.16 2.3e-05 0.22 0.16 0.19 0.21 7.5e-06 1.4e-04 2.5e-05 9.8e-06
10 NAcc gene expression C1qc 0.19 0.11 0.0e+00 0.17 0.18 0.17 0.18 2.0e-24 5.3e-26 1.6e-25 5.4e-26
11 IL gene expression C1qc 0.21 0.12 1.5e-05 0.14 0.18 0.2 0.18 2.5e-04 4.1e-05 2.0e-05 4.6e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density1.52.64.2-1.6-1.8-1.6-1.5-1.7-1.6-1.6-1.5-1.0-1.7-2.0
Area under the delay curve0.10.10.5-0.0-0.20.00.1-0.2-0.30.3-0.6-0.7-0.10.3
BMI with tail1.13.810.4-1.2-1.6-1.3-1.6-1.8-2.5-1.6-2.8-3.2-1.8-0.7
BMI without tail1.44.37.3-2.0-2.1-1.9-2.0-2.1-2.5-1.8-2.7-2.6-1.9-0.6
Body weight2.310.019.7-3.1-2.8-3.7-2.7-2.7-3.6-2.8-4.0-4.4-1.9-1.9
Weight adjusted by age0.20.40.60.60.70.30.70.70.50.80.3-0.00.80.6
Bone surface1.22.33.1-1.5-1.6-1.5-1.4-1.5-1.8-1.4-1.7-1.1-1.4-1.6
Bone volume1.22.22.9-1.6-1.7-1.6-1.4-1.5-1.6-1.4-1.5-0.9-1.3-1.7
Breakpoint value in progressive ratio session0.10.10.4-0.3-0.3-0.1-0.5-0.5-0.0-0.40.10.3-0.5-0.6
Number of licking bursts0.30.40.70.70.70.70.70.70.80.70.80.50.60.3
Context. condit. distance diff. score1.92.33.0-1.5-1.7-1.2-1.7-1.7-1.5-1.7-1.3-1.2-1.7-1.1
Locomotion velocity, session 11.31.42.3-1.2-1.5-0.8-1.3-1.4-0.9-1.2-0.7-0.9-1.5-1.3
Locomotion distance, session 10.60.71.9-0.7-1.0-0.2-0.9-1.0-0.3-1.10.1-0.0-1.4-1.1
Locomotion velocity, session 22.22.54.61.51.61.41.61.61.91.42.11.71.51.0
Locomotion distance, session 21.21.72.3-1.4-1.5-1.3-1.5-1.4-1.2-1.5-0.9-0.9-1.4-1.4
Locomotion velocity, session 30.30.41.10.40.01.10.20.00.60.30.70.7-0.61.0
Locomotion distance, session 33.33.66.6-1.9-2.2-1.3-2.2-2.2-1.5-2.3-1.0-1.0-2.6-1.8
Stereotopy head waving bouts, day 31.11.32.41.01.10.81.31.21.01.40.60.91.31.6
Stereotopy head waving duration, day 32.63.15.01.61.81.32.01.91.62.01.11.32.12.2
Locomotion velocity, session 72.62.83.8-1.9-1.9-1.4-1.9-1.9-1.8-1.7-1.9-1.1-1.8-0.8
Locomotion distance, session 70.50.60.9-0.8-0.8-0.6-1.0-0.8-0.8-0.8-1.0-0.4-0.80.0
Stereotopy head waving bouts, day 70.00.10.30.10.10.00.10.2-0.00.2-0.1-0.20.20.6
Stereotopy head waving duration, day 70.00.10.20.10.1-0.20.30.30.00.30.1-0.30.50.2
Locomotion velocity, session 80.20.20.5-0.3-0.6-0.1-0.5-0.6-0.4-0.5-0.3-0.6-0.7-0.6
Locomotion distance, session 83.34.87.4-2.1-2.5-1.7-2.4-2.4-2.1-2.5-1.7-1.7-2.7-1.9
Degree of sensitization distance3.53.66.21.82.11.42.12.11.52.31.01.12.52.2
Degree of sensitization stereotypy0.20.20.6-0.5-0.4-0.6-0.4-0.3-0.6-0.4-0.6-0.8-0.20.1
Conditioned locomotion2.02.33.51.41.51.91.41.41.61.61.51.71.11.7
Cocaine response after cond. corrected4.75.76.72.52.62.42.52.62.62.52.52.22.31.3
Cocaine response after cond. not corrected3.84.56.92.12.12.12.12.12.52.02.62.41.91.0
Cocaine response before conditioning1.51.72.7-1.6-1.5-1.5-1.4-1.4-1.0-1.6-0.7-0.6-1.3-1.3
Saline control response0.20.30.80.2-0.10.7-0.2-0.20.5-0.10.60.6-0.60.9
Bone: connectivity density0.91.42.9-1.2-1.2-1.2-1.2-1.2-1.2-1.3-0.9-0.3-1.2-1.7
Bone: cortical apparent density0.10.10.50.10.10.20.10.20.10.10.30.70.1-0.4
Bone: cortical area4.16.37.7-2.8-2.7-2.6-2.5-2.7-2.5-2.6-2.4-2.1-2.4-2.3
Bone: cortical porosity1.41.52.51.11.11.01.31.21.51.11.61.51.10.8
Bone: cortical porosity1.81.92.51.31.41.01.51.51.61.41.51.41.60.9
Bone: cortical thickness2.54.15.7-2.0-2.2-1.7-2.0-2.2-1.9-2.2-1.8-1.3-2.2-2.4
Bone: cortical thickness1.01.13.2-0.9-1.3-0.4-1.2-1.4-0.7-1.4-0.40.1-1.8-0.9
Bone: cortical tissue density0.20.20.80.40.40.50.40.50.40.40.50.90.4-0.1
Condit. Reinf. active minus inactive responses1.71.93.51.21.40.81.61.61.61.61.50.71.90.5
Condit. Reinf. active-inactive response ratio2.12.24.61.41.60.81.81.71.51.81.30.62.10.8
Condit. Reinf. active responses0.40.51.70.20.6-0.10.70.80.90.80.90.51.30.1
Condit. Reinf. inactive responses0.60.82.0-1.4-0.9-1.3-1.0-0.8-0.6-0.9-0.4-0.1-0.5-0.6
Incentive salience index mean0.50.61.60.30.70.00.80.81.10.91.10.61.30.2
Condit. Reinf. lever presses0.30.41.4-1.2-0.7-1.2-0.6-0.6-0.1-0.60.00.1-0.1-0.4
Condit. Reinf. active minus inactive responses0.70.91.7-0.7-1.0-0.6-1.0-1.0-1.1-1.0-1.0-1.3-1.1-0.7
Condit. Reinf. active-inactive response ratio1.11.22.41.51.21.21.31.21.11.20.90.51.00.7
Condit. Reinf. active responses5.07.08.2-2.7-2.8-2.4-2.9-2.8-2.8-2.8-2.6-2.6-2.7-1.8
Condit. Reinf. inactive responses10.013.017.9-4.2-3.8-3.8-4.1-3.8-3.8-3.8-3.5-3.0-3.2-2.1
Condit. Reinf. lever presses4.35.97.9-2.6-2.7-2.4-2.7-2.6-2.2-2.8-1.8-1.7-2.5-2.3
Condit. Reinf. lever reinforcers received4.96.88.1-2.7-2.8-2.5-2.8-2.8-2.8-2.7-2.5-2.5-2.5-1.9
Conditioned reinforcement - actives1.01.75.0-1.2-0.9-1.7-0.9-0.8-1.3-0.7-1.4-1.7-0.1-2.2
Conditioned reinforcement - inactives1.11.64.2-1.2-1.0-1.4-1.0-0.9-1.2-0.9-1.4-1.6-0.6-2.1
Conditioned locomotion1.62.04.8-1.4-1.3-1.5-1.4-1.2-1.3-1.1-1.3-1.8-0.8-2.2
Patch foraging indifference point 0 sec1.22.34.7-1.4-1.7-1.2-1.8-1.8-1.4-2.2-1.1-0.4-2.0-1.0
Patch foraging indifference point AUC1.62.33.2-1.7-1.6-1.6-1.7-1.8-1.4-1.7-1.0-1.3-1.6-1.2
Delay disc. indifference point, 0s delay0.70.71.2-0.6-0.9-0.4-0.7-1.0-1.1-0.7-1.1-1.1-1.1-0.1
Delay disc. indifference point, 16s delay0.10.10.2-0.2-0.1-0.20.0-0.1-0.30.2-0.4-0.40.1-0.4
Delay disc. indifference point, 2s delay0.20.31.20.1-0.10.00.1-0.1-0.50.2-0.8-0.9-0.01.1
Delay disc. indifference point, 24s delay0.50.51.20.60.80.30.80.90.70.80.60.41.10.6
Delay disc. indifference point, 4s delay0.10.10.4-0.0-0.0-0.00.20.0-0.20.4-0.6-0.60.10.2
Delay disc. indifference point, 8s delay0.10.10.7-0.1-0.3-0.1-0.1-0.3-0.40.1-0.6-0.8-0.30.2
Indifference point function ln k1.32.33.21.61.61.51.61.71.41.81.01.41.71.2
Indifference point function log k1.32.33.21.61.61.51.61.71.41.81.01.41.71.2
Patch foraging total patch changes 0 sec1.22.34.6-1.4-1.7-1.2-1.8-1.8-1.3-2.2-1.0-0.4-2.0-1.1
Patch foraging total patch changes 12 sec2.53.25.8-2.1-2.0-1.9-2.1-2.1-1.3-2.4-0.9-0.9-2.0-1.2
Patch foraging total patch changes 18 sec2.64.06.2-2.4-2.2-1.8-2.4-2.5-1.7-2.5-1.4-0.6-2.4-1.1
Patch foraging total patch changes 24 sec2.33.97.6-2.0-2.3-1.4-2.3-2.5-1.6-2.5-0.9-1.1-2.7-1.3
Patch foraging total patch changes 6 sec3.14.78.4-2.2-2.3-1.8-2.5-2.6-1.9-2.9-1.5-0.8-2.7-1.6
Patch foraging time to switch 0 sec0.30.61.90.60.60.50.60.71.00.31.01.40.70.2
Patch foraging water rate 0 sec0.10.10.60.40.10.80.2-0.10.20.30.10.2-0.40.5
Patch foraging water rate 12 sec0.20.31.4-0.1-0.60.2-0.5-0.8-0.4-0.5-0.2-0.3-1.2-0.5
Patch foraging water rate 18 sec0.91.52.4-1.4-1.1-1.5-0.9-1.1-1.4-0.8-1.4-1.5-0.6-1.0
Patch foraging water rate 24 sec0.50.71.30.70.80.80.90.80.61.20.50.60.91.1
Patch foraging water rate 6 sec0.30.51.20.80.61.10.60.40.70.90.60.50.10.8
Seeking ratio, delayed vs. immediate footshock1.72.13.9-1.2-1.6-0.8-1.3-1.7-1.5-1.5-1.7-1.5-2.00.1
Distance traveled before self-admin2.22.93.4-1.8-1.8-1.7-1.8-1.8-1.7-1.8-1.8-1.8-1.7-1.0
Distance traveled after self-admin3.13.84.6-2.1-2.1-1.9-2.1-2.1-1.9-2.2-1.5-1.5-2.1-1.9
Extensor digitorum longus weight0.83.24.4-1.5-1.9-1.3-1.8-2.0-1.8-1.9-1.5-1.7-2.1-1.9
Bone: elastic displacement0.30.31.2-0.4-0.5-0.2-0.4-0.5-0.1-0.70.01.1-0.8-0.8
Bone: elastic work0.91.12.2-1.0-1.3-0.7-1.0-1.3-1.0-1.1-1.00.1-1.5-1.2
Bone: endosteal estimation1.02.34.8-1.7-1.3-2.2-1.2-1.2-1.7-1.0-1.8-2.2-0.4-0.6
Bone: endosteal perimeter1.12.34.2-1.7-1.5-1.9-1.3-1.4-1.7-1.2-1.7-2.1-0.9-0.5
Epididymis fat weight0.20.71.21.01.00.70.91.00.51.00.20.31.11.0
Delta time in closed arm before/after self-admin0.20.21.10.20.5-0.30.40.70.30.40.30.11.0-0.1
Delta time in open arm before/after self-admin0.10.10.30.30.40.20.50.40.30.50.10.40.50.5
Diff in mean of infusions in LGA sessions0.10.10.9-0.3-0.10.0-0.1-0.10.50.10.51.00.0-0.0
Delay discount exponential model param0.10.10.4-0.1-0.0-0.1-0.3-0.00.2-0.40.50.7-0.1-0.4
Extinction: sum of active levers before priming0.30.41.5-0.2-0.2-0.7-0.4-0.3-0.9-0.4-1.2-0.80.1-0.3
Active lever presses in extinction session 60.20.20.40.60.50.40.40.30.60.30.40.40.5-0.5
Bone: final force2.84.45.8-2.3-2.4-2.0-2.2-2.4-2.1-2.2-1.9-1.5-2.2-1.8
Bone: final moment3.45.56.9-2.5-2.6-2.2-2.4-2.6-2.4-2.4-2.2-1.8-2.4-2.2
Food consumed during 24 hour testing period0.10.20.70.00.10.10.30.30.50.60.40.10.30.8
Glucose0.30.41.00.70.70.40.70.70.20.9-0.1-0.41.00.7
Heart weight0.10.21.30.20.10.10.20.1-0.00.2-0.3-0.30.11.1
Delay discount hyperbolic model param0.10.10.5-0.1-0.0-0.0-0.3-0.00.2-0.40.50.7-0.1-0.5
Intermittent access intake day 1-15 change0.91.83.0-1.4-1.2-1.6-1.2-1.1-1.5-0.9-1.7-1.5-0.7-1.5
Intermittent access intake escalation1.12.23.6-1.5-1.3-1.7-1.4-1.3-1.7-1.1-1.9-1.7-0.8-1.7
Intermittent access intake escalation 20.40.40.9-0.9-0.6-0.9-0.6-0.5-0.6-0.4-0.8-0.5-0.2-0.9
Intermitt. access day 1 inactive lever presses1.14.06.8-2.2-1.8-2.6-1.8-1.8-2.1-1.8-2.2-2.3-1.2-1.9
Intermitt. access day 15 inactive lever presses0.30.51.0-0.7-0.7-0.9-0.5-0.7-0.9-0.5-1.0-1.0-0.3-0.6
Intermitt. access escalation Index2.23.14.5-1.2-1.8-1.1-1.9-1.9-1.8-1.8-1.5-1.7-2.1-2.1
Intermittent access day 1 total infusions2.03.24.0-2.0-1.8-2.0-1.7-1.7-1.7-1.7-1.7-1.9-1.4-1.9
Intermittent access day 15 total infusions3.34.96.9-2.4-2.1-2.5-2.1-2.0-2.3-1.8-2.4-2.5-1.5-2.6
Intermittent access terminal intake (last 3 days)3.14.05.9-2.3-2.0-2.4-1.9-1.8-1.9-1.6-2.0-2.0-1.3-2.4
Intermittent access total infusions3.03.55.6-2.0-1.8-2.2-1.7-1.6-1.9-1.5-2.0-2.2-1.1-2.4
Intermittent access day 1 locomotion1.11.42.2-1.2-1.2-1.1-1.2-1.2-1.0-1.0-1.0-1.5-1.1-1.3
Intermittent access day 15 total locomotion0.30.51.2-1.1-0.8-0.9-0.9-0.7-0.1-0.70.1-0.3-0.4-1.1
Intermittent access total locomotion3.13.75.6-2.1-2.0-2.1-2.1-1.9-1.6-1.9-1.4-1.8-1.6-2.4
Intermittent access standard deviation2.24.58.2-2.1-1.8-2.5-1.8-1.7-2.4-1.5-2.9-2.8-0.9-2.1
Left kidney weight4.018.528.7-4.8-4.2-5.4-4.1-3.9-4.7-4.0-4.8-4.7-2.7-3.3
Right kidney weight1.25.712.8-2.9-2.2-3.6-2.1-2.0-2.6-2.1-2.7-2.6-0.8-1.3
Cocaine induced anxiety0.10.10.40.20.30.00.40.40.20.40.40.20.7-0.1
Post-drug Anxiety0.30.30.60.50.40.50.60.50.50.60.70.80.50.6
Baseline Anxiety0.10.10.50.30.10.40.2-0.00.10.1-0.00.1-0.20.7
Tail length0.52.06.3-2.2-1.4-2.5-1.2-1.0-1.3-1.0-1.5-1.0-0.1-0.6
Length with tail1.14.911.1-2.8-2.1-3.3-1.9-1.8-2.2-1.9-2.4-2.4-0.8-1.7
Length without tail0.41.23.5-1.0-0.7-1.6-0.6-0.6-1.1-0.8-1.3-1.9-0.2-1.1
Times rat made contact with spout0.70.82.50.40.40.80.50.41.30.41.51.60.00.6
Lifetime Intake2.53.05.7-1.8-1.6-2.1-1.5-1.4-1.7-1.3-1.8-2.1-0.9-2.4
Liver weight, left3.15.19.7-2.6-2.1-3.1-1.9-2.0-2.6-2.1-2.8-2.3-1.1-1.7
Liver weight, right0.71.33.5-1.4-0.8-1.9-1.0-0.8-1.3-1.0-1.3-1.3-0.0-0.1
Locomotor activity6.39.813.8-3.0-3.1-3.1-3.2-3.1-3.4-2.9-3.2-3.7-2.8-2.7
Locomotor testing distance3.35.98.1-2.4-2.5-2.4-2.5-2.4-2.7-2.2-2.5-2.8-2.2-1.8
Locomotor testing rearing3.26.57.9-2.6-2.7-2.5-2.8-2.6-2.7-2.6-2.6-2.5-2.5-1.7
Locomotion in novel chamber3.94.910.6-1.4-2.3-0.9-2.3-2.5-2.4-2.1-1.9-1.9-3.3-2.6
Locomotion in novel chamber post-restriction0.20.30.7-0.5-0.4-0.6-0.3-0.3-0.5-0.2-0.8-0.4-0.2-0.9
Fecal boli incidents, locomotor time 12.84.07.0-1.9-1.7-2.3-1.9-1.6-2.1-2.2-1.9-2.1-1.3-2.6
Change in fecal boli incidents, locomotor task5.45.37.22.42.52.32.52.42.32.71.91.72.32.3
Time >=10cm from walls, locomotor time 10.20.20.4-0.6-0.6-0.6-0.4-0.5-0.5-0.4-0.6-0.5-0.40.1
Bouts of movement, locomotor time 10.70.81.51.10.81.20.70.81.00.60.90.50.31.1
Total resting periods, locomotor time 10.70.81.51.20.91.20.80.81.00.70.90.60.41.1
Rest time, locomotor task time 13.94.85.92.42.42.22.32.32.12.41.91.92.22.1
Distance moved, locomotor task time 11.42.12.7-1.3-1.6-1.2-1.4-1.6-1.5-1.4-1.5-1.4-1.6-1.2
Vertical activity count, locomotor time 11.84.35.6-2.0-2.3-1.8-2.1-2.3-2.1-2.1-1.9-1.7-2.4-1.8
Time >=10cm from walls, locomotor time 20.00.00.30.30.10.20.00.00.0-0.2-0.1-0.3-0.10.5
Bouts of movement, locomotor time 21.52.33.41.71.51.71.51.51.51.51.31.31.21.8
Total resting periods, locomotor time 22.23.95.62.22.02.12.02.01.92.01.71.71.62.4
Rest time, locomotor task time 22.83.64.22.02.01.92.02.02.02.02.11.91.81.2
Distance moved, locomotor task time 21.72.02.6-1.5-1.5-1.5-1.4-1.5-1.6-1.2-1.6-1.6-1.3-0.5
Vertical activity count, locomotor time 23.04.25.3-2.1-2.2-2.0-2.0-2.2-2.3-2.0-2.2-1.9-2.0-1.2
Light reinforcement 10.40.91.3-1.0-0.9-0.9-1.0-1.1-0.9-1.0-0.7-0.9-1.1-0.6
Light reinforcement 20.20.30.6-0.3-0.5-0.1-0.5-0.6-0.8-0.5-0.7-0.6-0.8-0.3
Bone: marrow area1.02.24.8-1.7-1.3-2.2-1.2-1.2-1.7-1.0-1.8-2.2-0.4-0.6
Bone: maximum diameter3.15.87.4-2.7-2.4-2.7-2.3-2.4-2.6-2.2-2.7-2.7-1.8-1.6
Bone: maximum force3.56.27.4-2.7-2.7-2.6-2.5-2.6-2.7-2.3-2.7-2.2-2.3-2.0
Bone: maximum moment4.27.48.7-2.9-2.9-2.8-2.7-2.8-2.9-2.5-2.9-2.5-2.5-2.3
Mean time between licks in bursts0.10.10.7-0.0-0.0-0.2-0.2-0.1-0.3-0.3-0.4-0.8-0.1-0.5
Mean num. licks in bursts0.10.10.3-0.3-0.3-0.2-0.2-0.20.2-0.30.40.6-0.40.2
Cd content in liver7.68.511.4-2.7-2.9-2.7-3.0-3.0-3.4-3.0-3.0-2.9-2.8-2.5
Co content in liver1.41.63.3-1.8-1.3-1.4-1.6-1.4-0.9-1.8-0.40.1-1.3-0.6
Cu content in liver0.70.81.60.70.81.00.70.80.80.90.81.10.71.3
Fe content in liver0.20.20.7-0.3-0.3-0.4-0.2-0.2-0.30.0-0.3-0.8-0.1-0.8
K content in liver0.10.10.20.30.30.40.30.30.20.50.40.50.30.2
Mg content in liver0.10.10.20.30.30.50.30.30.20.50.40.40.40.4
Mn content in liver0.50.61.6-0.5-0.3-1.0-0.4-0.3-1.0-0.5-1.0-1.30.1-1.0
Na content in liver1.41.52.3-1.5-1.4-1.4-1.3-1.2-1.1-1.0-0.9-1.3-0.9-1.1
Rb content in liver0.50.61.50.70.90.31.00.90.70.90.70.31.20.1
Se content in liver1.51.83.01.51.61.21.51.61.21.61.20.41.70.5
Sr content in liver1.41.21.7-1.1-1.2-0.9-1.3-1.2-1.0-1.2-0.8-0.9-1.3-1.1
Zn content in liver0.10.10.3-0.4-0.5-0.0-0.5-0.4-0.3-0.20.1-0.1-0.5-0.1
Bone: minimum diameter0.81.54.3-1.6-1.1-2.1-1.0-1.0-1.2-1.0-1.3-1.3-0.2-0.9
Time in familiar zone, hab. session 10.20.20.7-0.1-0.30.2-0.4-0.4-0.3-0.6-0.20.5-0.80.0
Time in novel zone, hab. session 10.10.10.30.40.40.20.50.40.30.60.2-0.10.50.3
Total zone transitions, hab. session 10.71.01.8-1.0-1.1-0.8-1.1-1.1-0.7-1.3-0.3-0.3-1.3-1.2
Total locomotion distance, hab. session 11.01.42.8-1.2-1.3-1.2-1.3-1.3-1.0-1.7-0.6-0.3-1.3-1.4
Locomotion velocity, hab. session 10.70.91.9-1.1-1.0-1.1-1.0-1.0-0.7-1.4-0.3-0.1-1.0-1.3
Time in familiar zone, hab. session 20.10.10.8-0.4-0.3-0.1-0.3-0.30.1-0.50.10.9-0.4-0.1
Time in novel zone, hab. session 20.40.40.80.90.70.90.60.60.30.80.20.20.50.8
Total zone transitions, hab. session 22.02.54.3-1.7-1.9-1.2-1.9-1.8-1.4-1.8-1.1-0.9-2.1-1.1
Total locomotion distance, hab. session 21.11.53.0-1.3-1.4-0.8-1.5-1.4-1.0-1.6-0.7-0.2-1.7-0.8
Locomotion velocity, hab. session 21.82.43.9-1.7-1.8-1.2-1.9-1.7-1.3-1.9-1.0-0.6-2.0-1.2
Novel to familiar place preference ratio0.50.61.20.80.90.51.00.90.41.0-0.10.21.10.8
Novelty place preference0.40.41.10.50.70.20.80.70.30.9-0.20.01.10.7
Time in novel zone, NPP test0.40.51.00.60.80.40.80.80.30.9-0.20.11.00.9
Total zone transitions, NPP test0.60.81.5-1.0-1.1-0.6-1.1-1.0-0.5-1.1-0.1-0.6-1.2-0.9
Total locomotion distance, NPP test0.50.61.3-1.0-1.0-0.6-1.0-0.9-0.5-1.1-0.20.1-1.0-0.5
Locomotion velocity, NPP test0.60.91.7-1.1-1.1-0.9-1.1-1.0-0.5-1.3-0.2-0.1-1.1-1.0
Intraocular pressure1.52.13.6-1.5-1.7-1.1-1.6-1.7-1.1-1.8-0.5-0.7-1.9-1.6
Delta distance traveled before/after self-admin0.40.41.3-0.6-0.7-0.6-0.6-0.7-0.5-0.7-0.2-0.0-0.6-1.1
Delta ambulatory time before/after self-admin0.10.10.4-0.2-0.3-0.2-0.4-0.4-0.1-0.50.30.3-0.4-0.6
Parametrial fat weight1.63.76.01.92.31.52.22.21.72.11.21.42.41.6
Pavlov. Cond. lever latency0.50.61.70.90.90.90.80.80.50.80.30.30.61.3
Pavlov. Cond. magazine entry latency0.50.60.9-0.8-1.0-0.6-0.8-0.9-0.7-0.8-0.8-0.2-0.9-0.8
Pavlov. Cond. change in total contacts0.10.10.2-0.3-0.3-0.3-0.3-0.3-0.3-0.3-0.40.1-0.3-0.2
Pavlov. Cond. index score0.60.71.2-0.9-0.9-0.9-0.9-0.9-0.7-0.9-0.8-0.5-0.7-1.1
Pavlov. Cond. latency score0.50.61.3-0.9-0.9-0.8-0.8-0.8-0.6-0.8-0.5-0.2-0.7-1.1
Pavlov. Cond. lever contacts0.10.10.5-0.5-0.4-0.5-0.3-0.30.0-0.30.10.1-0.2-0.7
Pavlov. Cond. magazine entry number2.12.73.51.81.91.61.81.81.61.71.71.01.61.5
Pavlov. Cond. intertrial magazine entries8.39.913.03.13.23.03.23.33.63.23.62.93.12.3
Pavlov. Cond. lever-magazine prob. diff.0.30.30.6-0.6-0.7-0.6-0.6-0.6-0.5-0.5-0.6-0.3-0.5-0.8
Pavlov. Cond. response bias1.01.31.8-1.3-1.3-1.2-1.3-1.2-0.9-1.2-0.9-0.4-1.1-1.2
Pavlov. Cond. lever latency2.53.45.02.12.21.62.22.21.62.11.21.02.21.3
Pavlov. Cond. magazine entry latency0.00.00.1-0.1-0.2-0.1-0.0-0.00.20.20.2-0.20.10.2
Pavlov. Cond. change in total contacts2.13.44.4-2.1-2.0-2.0-2.0-1.9-1.8-1.9-1.7-1.7-1.6-1.4
Pavlov. Cond. index score1.01.32.3-1.4-1.5-1.0-1.4-1.4-0.9-1.2-0.6-0.7-1.3-0.6
Pavlov. Cond. latency score0.60.81.6-1.1-1.3-0.7-1.1-1.1-0.6-1.0-0.3-0.4-1.2-0.5
Pavlov. Cond. lever contacts2.83.85.5-2.3-2.3-1.9-2.3-2.2-1.7-2.2-1.3-1.1-2.1-1.4
Pavlov. Cond. magazine entry number0.40.50.80.80.90.60.80.80.70.60.60.90.70.3
Pavlov. Cond. intertrial magazine entries2.13.24.51.41.81.41.81.91.72.11.51.62.02.1
Pavlov. Cond. lever-magazine prob. diff.1.01.32.4-1.4-1.5-1.0-1.4-1.4-0.9-1.2-0.6-0.7-1.3-0.5
Pavlov. Cond. response bias2.23.04.3-2.0-2.1-1.6-2.1-2.0-1.6-1.8-1.3-1.3-1.8-1.2
Time in closed arm before self-admin1.11.41.9-1.2-1.4-1.1-1.1-1.4-1.3-1.1-1.2-1.2-1.3-0.8
Time in closed arm after self-admin0.10.10.4-0.20.1-0.30.30.30.30.20.50.10.60.5
Time in open arm before self-admin0.50.51.40.70.60.90.20.61.00.41.20.90.2-0.1
Time in open arm after self-admin1.21.31.91.41.31.21.11.31.21.30.91.01.10.6
Bone: periosteal estimation3.06.49.6-2.9-2.5-3.1-2.4-2.5-2.8-2.2-2.8-2.8-1.7-1.7
Bone: periosteal perimeter4.17.19.2-3.0-2.9-3.0-2.6-2.8-2.8-2.5-2.8-2.6-2.2-2.0
Bone: post-yield work0.50.72.4-0.8-0.5-1.1-0.6-0.4-1.1-0.1-1.3-1.50.20.0
Progressive ratio test 1 active lever presses0.70.82.6-1.0-0.7-1.2-0.8-0.7-0.7-0.6-0.6-1.1-0.2-1.6
Progressive ratio test 1 breakpoint0.81.02.8-1.1-0.9-1.2-0.9-0.8-0.8-0.7-0.7-1.1-0.4-1.7
Progressive ratio test 1 inactive lever presses0.91.22.3-1.3-0.9-1.5-0.9-0.8-1.2-0.8-1.2-1.5-0.3-1.2
Progressive ratio test 2 active lever presses2.32.76.3-1.9-1.6-2.0-1.5-1.5-1.3-1.6-1.2-1.4-1.0-2.5
Progressive ratio test 2 breakpoint2.32.76.4-1.9-1.6-2.1-1.5-1.5-1.3-1.6-1.1-1.4-0.9-2.5
Progressive ratio test 2 inactive lever presses1.11.75.6-1.4-1.2-1.6-1.1-1.2-1.0-1.2-0.7-1.2-0.7-2.4
Incentive Sensitization - Responses1.72.44.0-1.9-1.7-2.0-1.5-1.6-1.3-1.8-1.0-0.9-1.2-1.9
Incentive Sensitization - Breakpoint1.82.44.0-1.8-1.6-2.0-1.4-1.5-1.3-1.8-1.1-1.0-1.0-1.9
Sum of active levers in priming session hrs 5-60.20.10.60.80.40.60.40.10.10.4-0.3-0.10.2-0.2
Progressive ratio0.10.21.3-0.00.20.10.20.20.10.20.00.20.41.2
Food seeking constrained by brief footshock0.10.20.70.10.3-0.30.40.40.40.30.40.20.80.5
Seeking ratio, punishment vs. effort0.10.10.7-0.0-0.1-0.3-0.2-0.1-0.0-0.20.0-0.3-0.0-0.9
Retroperitoneal fat weight0.20.92.70.91.30.31.11.20.40.9-0.2-0.31.60.8
Reaction time number correct0.61.11.71.11.11.01.11.20.91.31.00.81.10.5
Reaction time mean minus median0.10.30.9-0.1-0.60.1-0.7-0.7-0.7-0.4-0.7-0.5-0.9-0.3
Reaction time mean minus median AUC0.10.31.0-0.2-0.70.0-0.7-0.8-0.6-0.4-0.7-0.2-1.0-0.2
Reaction time num false alarms0.50.71.5-0.7-1.0-0.8-0.8-0.8-1.0-0.5-0.9-1.2-0.9-0.1
Reaction time num false alarms AUC0.40.71.6-0.6-0.9-0.7-0.8-0.7-1.0-0.4-1.0-1.3-0.8-0.1
Reaction time trials correct on left0.61.11.71.11.11.01.11.20.91.31.00.81.10.5
Reaction time trials on left0.61.11.71.11.11.01.11.20.91.31.10.81.10.5
Reaction time mean0.20.30.6-0.5-0.6-0.3-0.8-0.6-0.4-0.5-0.40.0-0.6-0.3
Reaction time mean AUC0.00.00.1-0.0-0.20.2-0.3-0.1-0.1-0.1-0.10.4-0.3-0.1
Median of all reaction times0.00.10.2-0.4-0.3-0.2-0.5-0.2-0.2-0.2-0.10.2-0.20.0
Reaction time omissions0.30.40.5-0.6-0.7-0.5-0.7-0.7-0.6-0.5-0.4-0.6-0.7-0.6
Reaction time false alarm rate0.81.22.1-0.9-1.2-1.0-1.0-1.1-1.3-0.9-1.3-1.4-1.1-0.3
Reaction time premature initiation rate0.70.92.90.90.61.10.40.41.2-0.01.71.7-0.10.5
Reaction time premature initiations0.91.54.21.31.01.40.80.81.50.52.11.90.30.6
Std. dev. reaction times0.20.31.1-0.2-0.70.2-0.9-0.7-0.4-0.6-0.3-0.0-1.1-0.5
Reaction time trials completed0.61.11.71.11.11.01.11.20.91.31.10.81.10.5
Reaction time trials AUC0.50.91.61.01.10.81.01.10.81.30.90.61.10.5
Run reversals in cocaine runway, females0.80.71.8-0.7-0.9-0.4-0.9-1.0-0.6-1.1-0.5-0.3-1.3-1.1
Run reversals in cocaine runway, males0.10.10.50.0-0.20.0-0.2-0.3-0.3-0.2-0.4-0.7-0.4-0.4
Latency to leave start box in cocaine runway0.80.91.30.91.00.91.01.01.10.90.90.81.01.1
Latency to leave start box in cocaine runway, F0.10.10.50.0-0.1-0.0-0.1-0.1-0.3-0.1-0.7-0.7-0.20.5
Latency to leave start box in cocaine runway, M2.92.75.51.31.51.31.61.62.11.42.32.01.60.9
Std. dev. time between licks in bursts1.01.42.8-1.1-1.1-1.0-1.3-1.3-1.0-1.7-0.6-0.6-1.3-1.6
Total sessions with >9 infusions2.73.35.8-1.7-1.5-2.2-1.6-1.4-1.9-1.3-2.1-2.4-0.8-2.4
Short access day 1 total inactive lever presses0.70.93.0-0.8-0.9-1.0-0.8-0.7-0.9-0.9-0.7-0.9-0.6-1.7
Short access day 10 total inactive lever presses0.82.02.7-1.4-1.5-1.2-1.6-1.5-1.6-1.5-1.5-1.1-1.6-1.0
Short access day 1 total infusions2.93.97.7-1.9-1.8-2.3-1.8-1.7-1.9-1.7-1.9-2.2-1.2-2.8
Short access day 10 total infusions1.52.03.5-1.5-1.3-1.8-1.3-1.1-1.4-1.1-1.4-1.9-0.6-1.7
Short access total infusions1.72.15.5-1.4-1.2-1.8-1.2-1.0-1.3-1.0-1.4-1.9-0.4-2.3
Short access day 1 locomotion1.11.43.1-1.0-1.0-1.4-1.0-1.0-1.2-0.8-1.1-1.6-0.6-1.8
Short access day 10 total locomotion2.44.47.4-2.2-2.0-2.4-2.0-1.9-2.0-1.8-2.0-2.7-1.5-2.5
Short access total locomotion3.44.17.9-1.9-1.8-2.2-1.9-1.7-2.0-1.5-2.1-2.8-1.2-2.5
One hour access (0.3 mA shock)5.15.97.3-2.7-2.5-2.6-2.6-2.4-2.5-2.2-2.4-2.1-2.0-2.5
Compulsive drug intake2.12.43.9-1.7-1.5-2.0-1.4-1.4-1.8-1.6-1.8-1.4-1.2-0.9
One hour access (shock baseline)1.42.23.0-1.5-1.6-1.3-1.7-1.6-1.4-1.4-1.2-1.3-1.5-1.7
Social response proportion0.30.40.80.90.80.40.70.60.60.40.70.30.60.2
Social responses1.92.44.9-1.3-1.5-1.5-1.4-1.6-1.7-1.5-1.3-2.2-1.5-1.3
Social time0.10.10.3-0.1-0.2-0.3-0.2-0.1-0.20.2-0.0-0.5-0.0-0.5
Soleus weight4.413.116.0-3.3-3.7-3.2-3.8-3.8-3.6-4.0-3.0-3.6-3.6-4.0
Bone: stiffness3.65.97.4-2.6-2.5-2.7-2.4-2.4-2.6-2.2-2.7-2.6-2.0-1.7
Tibialis anterior weight2.58.511.6-2.4-3.0-2.2-3.1-3.2-2.8-3.4-2.3-2.7-3.4-3.1
Time to tail flick, vehicle, before self-admin0.80.91.81.31.21.01.01.10.41.30.2-0.30.90.3
Time to tail flick, vehicle, after self-admin1.01.43.91.21.40.41.41.60.81.30.70.12.00.6
Time to tail flick, test, before self-admin0.20.21.60.2-0.00.3-0.4-0.0-0.2-0.10.10.2-0.4-1.3
Time to tail flick, test, after self-admin0.30.31.30.10.4-0.50.60.70.10.5-0.1-0.31.10.5
Delta time to tail flick, vehicle, before/after SA0.10.10.5-0.3-0.1-0.7-0.10.1-0.2-0.4-0.2-0.30.4-0.4
Delta time to tail flick, test, before/after SA0.40.41.8-0.10.3-0.50.70.50.10.5-0.2-0.41.01.3
Tibia length1.23.35.4-2.1-1.7-2.3-1.8-1.6-2.1-1.7-2.2-2.1-1.0-1.1
Ambulatory time before self-admin1.52.23.3-1.8-1.6-1.6-1.6-1.6-1.4-1.5-1.4-1.3-1.4-0.7
Ambulatory time after self-admin3.03.54.6-2.1-2.1-2.0-2.0-2.1-1.8-2.1-1.4-1.4-1.8-1.6
Bone: tissue strength1.81.93.7-1.1-1.0-1.5-1.1-1.0-1.6-0.9-1.7-1.9-0.6-1.8
Total heroin consumption0.20.30.5-0.3-0.5-0.4-0.5-0.7-0.5-0.5-0.7-0.6-0.6-0.4
Bone: trabecular number0.71.11.8-1.0-1.2-0.8-1.1-1.2-1.1-1.1-1.0-0.4-1.3-1.1
Bone: trabecular spacing1.41.93.01.51.51.21.41.51.71.21.70.91.40.6
Bone: trabecular thickness0.81.01.4-1.2-1.1-1.2-1.0-1.0-1.1-0.8-0.8-0.9-0.7-1.2
Bone: trabecular tissue density0.10.20.7-0.3-0.1-0.5-0.10.0-0.40.1-0.7-0.80.3-0.3
Water consumed over 24 hours0.30.41.10.20.30.50.60.41.00.61.01.00.20.4
Number of responses in last shaping day0.70.71.8-0.9-0.6-1.1-0.8-0.6-0.9-0.7-1.0-1.0-0.3-1.3