Hub : Genes

C1h19orf81

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr1_103994174_103994823	0.03	0.02	2.7e-04	0.02	0.02	0.02	0.02	1.2e-03	1.2e-03	5.7e-04	1.0e-03
2	IC	gene expression	C1h19orf81	0.05	0.04	9.7e-03	0.02	0.03	0.01	0.02	4.1e-02	1.5e-02	9.3e-02	5.1e-02
3	Brain	alternative TSS	XM_039104739.2	0.04	0.03	3.9e-04	0.03	0.04	0.03	0.03	6.7e-04	3.0e-04	5.8e-04	5.5e-04
4	NAcc	intron excision ratio	chr1_103994174_103994564	0.02	0.01	2.8e-04	0.02	0.02	0.02	0.02	2.7e-04	1.8e-04	2.2e-04	3.0e-04
5	Brain	alternative TSS	NM_001401372.1	0.03	0.02	1.1e-03	0.03	0.03	0.03	0.03	1.7e-03	1.1e-03	1.5e-03	2.0e-03
6	pVTA	intron excision ratio	chr1_103994174_103994564	0.06	0.04	8.4e-05	0.05	0.05	0.06	0.05	4.0e-05	4.9e-05	1.7e-05	4.2e-05
7	BLA	gene expression	C1h19orf81	0.09	0.07	3.3e-03	0.06	0.04	0.05	0.06	7.2e-04	2.3e-03	8.5e-04	4.9e-04
8	PL	gene expression	C1h19orf81	0.03	0.02	2.8e-04	0.03	0.03	0.03	0.03	2.0e-04	3.8e-04	2.1e-04	3.9e-04
9	PL	alternative TSS	XM_039104739.2	0.03	0.02	5.8e-04	0.02	0.03	0.01	0.02	2.4e-03	5.7e-04	1.6e-02	7.1e-03
10	NAcc	gene expression	C1h19orf81	0.02	0.02	1.8e-04	0.01	0.02	0.01	0.02	2.2e-03	5.4e-04	3.8e-03	1.3e-03
11	Brain	gene expression	C1h19orf81	0.06	0.04	4.6e-06	0.03	0.05	0.05	0.04	6.0e-04	2.6e-05	3.2e-05	5.2e-05
12	pVTA	intron excision ratio	chr1_103994174_103994823	0.04	0.03	1.7e-03	0.03	0.03	0.01	0.03	3.6e-03	2.0e-03	1.9e-02	3.1e-03
13	pVTA	gene expression	C1h19orf81	0.06	0.04	8.1e-04	0.02	0.03	0.04	0.02	1.2e-02	1.6e-03	7.6e-04	5.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bone: apparent density	0.2	0.4	0.9	0.4	0.6	-0.6	0.6	0.6	-0.9	0.1	-0.7	-0.7	0.6	0.6	-0.8	-1.0
Area under the delay curve	0.4	0.6	1.3	-0.1	-0.6	0.6	-0.7	-0.6	-0.2	-0.9	1.0	0.8	-1.0	-1.1	0.6	0.8
BMI with tail	0.3	1.2	2.3	0.8	1.0	-1.0	1.1	1.1	-1.0	0.5	-1.1	-1.2	1.2	1.2	-1.2	-1.5
BMI without tail	0.0	0.2	0.7	-0.6	0.1	-0.2	0.1	0.1	-0.4	-0.8	-0.2	-0.1	0.0	-0.1	-0.6	-0.8
Body weight	0.8	3.7	7.2	-2.7	-1.9	1.9	-2.0	-1.9	1.8	-2.5	1.9	1.9	-1.9	-2.0	1.1	0.9
Weight adjusted by age	0.0	0.1	0.3	0.4	0.1	-0.1	0.2	0.1	0.4	0.5	-0.3	-0.2	0.4	0.5	0.2	0.2
Bone surface	0.9	1.7	4.2	0.6	1.3	-1.4	1.1	1.3	-1.9	-0.5	-1.3	-1.1	0.7	0.5	-2.1	-1.8
Bone volume	0.3	0.7	2.0	0.0	0.6	-0.7	0.5	0.7	-1.2	-0.7	-0.7	-0.6	0.4	0.3	-1.4	-1.4
Breakpoint value in progressive ratio session	0.2	0.4	1.3	0.7	0.5	-0.6	0.5	0.6	-0.7	-0.6	-0.6	-0.6	0.5	0.4	-1.1	-1.0
Number of licking bursts	0.1	0.3	0.8	0.6	0.8	-0.7	0.6	0.6	-0.6	0.9	-0.5	-0.4	0.2	0.2	-0.3	0.1
Context. condit. distance diff. score	7.9	9.6	13.1	2.9	3.5	-3.6	3.3	3.5	-3.6	2.2	-3.3	-3.1	2.7	2.4	-3.2	-2.5
Locomotion velocity, session 1	2.2	2.4	6.4	2.1	1.6	-1.5	1.7	1.5	-1.0	2.5	-1.4	-1.5	1.6	1.7	-0.6	-0.3
Locomotion distance, session 1	3.8	4.9	5.6	2.1	2.2	-2.2	2.3	2.3	-2.2	1.9	-2.3	-2.3	2.4	2.4	-2.0	-2.1
Locomotion velocity, session 2	0.9	1.0	3.3	1.2	1.0	-0.9	1.1	0.9	-0.7	1.8	-0.9	-1.0	1.1	1.2	-0.2	-0.3
Locomotion distance, session 2	0.6	0.8	1.0	0.7	1.0	-1.0	1.0	0.9	-1.0	0.8	-0.9	-0.9	0.9	0.8	-0.9	-0.8
Locomotion velocity, session 3	1.0	1.2	4.1	1.3	1.2	-1.1	1.2	1.1	-0.7	2.0	-0.8	-1.0	0.9	1.0	-0.3	0.1
Locomotion distance, session 3	0.1	0.1	0.3	0.2	0.2	-0.1	0.2	0.2	-0.2	0.3	-0.3	-0.3	0.4	0.5	-0.2	-0.5
Stereotopy head waving bouts, day 3	2.0	2.4	3.2	1.1	1.7	-1.7	1.7	1.7	-1.6	1.8	-1.4	-1.7	1.6	1.6	-1.3	-1.2
Stereotopy head waving duration, day 3	2.2	2.7	3.6	1.6	1.9	-1.8	1.8	1.8	-1.6	1.8	-1.5	-1.7	1.6	1.6	-1.4	-1.1
Locomotion velocity, session 7	0.2	0.2	1.3	0.4	-0.1	0.1	-0.1	-0.1	0.4	0.6	0.3	0.4	-0.5	-0.5	0.6	1.1
Locomotion distance, session 7	0.2	0.2	0.6	0.4	0.6	-0.6	0.5	0.5	-0.8	0.0	-0.5	-0.4	0.2	0.1	-0.7	-0.5
Stereotopy head waving bouts, day 7	0.2	0.2	1.0	0.6	0.1	-0.0	0.1	-0.0	0.5	0.8	0.2	0.1	-0.2	-0.1	0.5	1.0
Stereotopy head waving duration, day 7	0.2	0.2	0.9	0.7	0.1	-0.0	0.1	0.0	0.5	0.8	0.2	0.1	-0.0	-0.0	0.5	0.9
Locomotion velocity, session 8	4.9	5.9	13.3	3.0	2.5	-2.3	2.6	2.4	-1.7	3.6	-2.2	-2.4	2.6	2.7	-1.0	-0.9
Locomotion distance, session 8	9.7	14.1	17.0	3.9	4.1	-4.1	4.1	4.1	-4.0	3.4	-3.9	-3.9	3.6	3.4	-3.3	-2.8
Degree of sensitization distance	0.2	0.2	0.4	0.4	0.5	-0.5	0.4	0.5	-0.6	0.2	-0.4	-0.3	0.2	0.1	-0.4	-0.1
Degree of sensitization stereotypy	0.7	0.8	2.5	-0.0	-0.7	0.8	-0.7	-0.8	1.2	0.0	0.9	0.9	-0.9	-0.9	1.1	1.6
Conditioned locomotion	0.1	0.1	0.2	-0.3	-0.1	0.1	-0.2	-0.1	0.3	-0.0	0.3	0.2	-0.3	-0.3	0.3	0.5
Cocaine response after cond. corrected	1.3	1.9	3.1	-1.2	-1.7	1.7	-1.5	-1.6	1.8	-0.7	1.3	1.3	-0.9	-0.7	1.7	1.1
Cocaine response after cond. not corrected	1.1	1.6	2.5	-1.0	-1.5	1.5	-1.3	-1.5	1.6	-0.6	1.2	1.2	-0.9	-0.8	1.6	1.1
Cocaine response before conditioning	0.2	0.3	0.5	0.7	0.7	-0.7	0.6	0.6	-0.5	0.5	-0.4	-0.4	0.3	0.2	-0.4	-0.0
Saline control response	0.2	0.2	0.6	-0.8	-0.4	0.4	-0.5	-0.4	0.4	-0.4	0.5	0.5	-0.6	-0.6	0.3	0.4
Bone: connectivity density	1.8	2.8	4.5	1.6	1.8	-1.9	1.7	1.8	-2.1	0.8	-1.8	-1.7	1.4	1.2	-1.9	-1.6
Bone: cortical apparent density	1.2	1.9	3.3	-1.8	-1.4	1.4	-1.5	-1.4	1.1	-1.7	1.3	1.4	-1.5	-1.6	0.8	0.8
Bone: cortical area	0.4	0.7	2.4	-1.2	-0.8	0.8	-0.9	-0.8	0.3	-1.5	0.7	0.8	-0.9	-0.9	0.1	-0.0
Bone: cortical porosity	0.5	0.6	3.4	0.9	0.3	-0.2	0.5	0.3	0.4	1.8	-0.2	-0.3	0.6	0.7	0.8	0.9
Bone: cortical porosity	0.8	0.8	4.2	1.3	0.7	-0.6	0.8	0.7	0.0	2.0	-0.5	-0.6	0.8	1.0	0.4	0.7
Bone: cortical thickness	0.6	1.0	1.3	-1.1	-1.1	1.1	-1.1	-1.1	1.1	-0.6	1.0	1.1	-0.9	-0.9	1.1	0.9
Bone: cortical thickness	0.1	0.2	0.4	0.2	0.3	-0.3	0.3	0.3	-0.5	0.4	-0.6	-0.4	0.5	0.5	-0.3	-0.6
Bone: cortical tissue density	1.2	1.9	3.2	-1.8	-1.4	1.4	-1.5	-1.4	1.1	-1.7	1.3	1.4	-1.5	-1.6	0.9	0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.7	-0.1	0.1	-0.2	-0.1	-0.3	-0.4	-0.1	0.1	-0.2	-0.3	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.0	0.0	-0.1	0.0	0.1	-0.1	-0.1	-0.1	-0.0	-0.0	-0.1	-0.1	0.0
Condit. Reinf. active responses	0.3	0.4	1.1	-1.1	-0.5	0.5	-0.6	-0.5	0.1	-0.9	0.4	0.6	-0.8	-0.9	0.1	0.2
Condit. Reinf. inactive responses	0.8	1.0	2.0	-1.4	-0.9	0.9	-1.1	-1.0	0.7	-1.4	1.0	1.0	-1.2	-1.2	0.3	0.4
Incentive salience index mean	0.0	0.0	0.2	-0.5	-0.1	0.1	-0.2	-0.1	-0.1	-0.3	-0.1	0.2	-0.2	-0.3	-0.0	-0.1
Condit. Reinf. lever presses	0.9	1.3	1.6	-1.2	-1.2	1.2	-1.2	-1.2	1.0	-1.1	1.0	1.2	-1.2	-1.1	1.0	0.8
Condit. Reinf. active minus inactive responses	0.3	0.4	1.3	-0.9	-0.3	0.3	-0.5	-0.4	0.2	-0.9	0.5	0.7	-1.0	-1.2	-0.0	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.5	-0.3	-0.3	0.3	-0.3	-0.3	0.4	0.1	0.4	0.4	-0.4	-0.4	0.5	0.7
Condit. Reinf. active responses	0.5	0.7	2.6	-1.2	-0.3	0.3	-0.6	-0.4	-0.1	-1.6	0.5	0.7	-1.1	-1.4	-0.4	0.1
Condit. Reinf. inactive responses	0.4	0.6	3.4	-1.0	-0.0	-0.1	-0.2	0.0	-0.8	-1.8	-0.1	0.1	-0.5	-0.7	-1.2	-1.1
Condit. Reinf. lever presses	0.5	0.8	3.9	-1.2	-0.1	-0.0	-0.4	-0.1	-0.6	-2.0	0.2	0.4	-1.0	-1.3	-1.0	-0.5
Condit. Reinf. lever reinforcers received	0.6	0.8	3.6	-1.4	-0.3	0.2	-0.7	-0.4	-0.2	-1.9	0.4	0.7	-1.2	-1.4	-0.6	-0.1
Conditioned reinforcement - actives	0.0	0.1	0.3	-0.1	0.2	-0.2	0.3	0.2	0.2	0.2	-0.2	-0.4	0.5	0.5	-0.1	-0.3
Conditioned reinforcement - inactives	0.0	0.1	0.2	-0.3	0.1	-0.2	-0.0	0.1	0.1	-0.3	0.3	0.1	-0.3	-0.5	-0.1	0.2
Conditioned locomotion	0.6	0.9	1.6	0.4	0.9	-0.9	1.0	0.9	-0.8	0.9	-1.0	-1.0	1.2	1.2	-0.8	-1.3
Patch foraging indifference point 0 sec	0.6	1.6	5.4	-1.3	-0.4	0.3	-0.9	-0.6	0.4	-2.0	1.1	1.2	-2.0	-2.3	-0.3	1.2
Patch foraging indifference point AUC	0.6	1.3	2.5	0.8	1.2	-1.2	1.2	1.2	-1.6	0.6	-1.4	-1.1	1.0	0.9	-1.2	-1.2
Delay disc. indifference point, 0s delay	0.6	0.6	1.5	0.8	0.8	-0.8	0.7	0.8	-1.2	0.4	-0.8	-0.7	0.6	0.5	-1.0	-0.9
Delay disc. indifference point, 16s delay	0.8	1.2	2.0	-1.0	-1.1	1.0	-1.1	-1.1	0.1	-0.7	1.3	1.2	-1.4	-1.4	1.2	0.9
Delay disc. indifference point, 2s delay	2.2	2.4	4.4	1.8	1.7	-1.8	1.6	1.7	-2.1	0.9	-1.4	-1.5	1.3	1.1	-1.7	-1.2
Delay disc. indifference point, 24s delay	0.0	0.1	0.3	0.4	0.3	-0.3	0.2	0.3	-0.4	0.1	0.1	-0.0	-0.2	-0.3	-0.0	0.6
Delay disc. indifference point, 4s delay	0.5	0.5	1.0	-0.4	-0.7	0.6	-0.7	-0.7	0.2	-1.0	0.9	0.8	-0.9	-1.0	0.5	0.6
Delay disc. indifference point, 8s delay	1.3	2.2	3.4	-0.5	-1.5	1.4	-1.5	-1.5	0.8	-1.5	1.8	1.6	-1.8	-1.8	1.4	1.6
Indifference point function ln k	0.0	0.1	0.7	-0.3	-0.1	0.0	-0.2	-0.1	-0.0	-0.8	0.2	0.2	-0.3	-0.4	-0.4	-0.1
Indifference point function log k	0.0	0.1	0.7	-0.3	-0.1	0.0	-0.2	-0.1	-0.0	-0.8	0.2	0.2	-0.3	-0.4	-0.4	-0.1
Patch foraging total patch changes 0 sec	0.5	1.6	5.3	-1.2	-0.5	0.4	-0.9	-0.6	0.5	-1.9	1.2	1.2	-2.0	-2.3	-0.1	1.3
Patch foraging total patch changes 12 sec	0.2	0.3	1.5	-0.8	0.1	-0.2	-0.1	0.1	-0.5	-1.2	-0.1	0.1	-0.4	-0.6	-0.7	-0.5
Patch foraging total patch changes 18 sec	0.8	1.9	3.7	1.1	1.9	-1.9	1.5	1.7	-1.9	0.5	-1.3	-1.2	0.5	0.2	-1.8	-0.6
Patch foraging total patch changes 24 sec	1.0	3.3	6.1	1.5	2.0	-2.0	1.8	1.9	-2.5	0.3	-2.0	-1.7	1.3	1.1	-2.4	-2.0
Patch foraging total patch changes 6 sec	0.2	0.3	1.0	-0.6	0.1	-0.1	-0.2	0.0	-0.2	-1.0	0.2	0.3	-0.8	-1.0	-0.4	0.2
Patch foraging time to switch 0 sec	0.3	1.3	4.0	-0.1	-1.0	1.2	-0.7	-1.0	1.9	1.1	1.1	0.8	-0.2	0.1	2.0	1.6
Patch foraging water rate 0 sec	0.2	0.6	1.8	0.3	0.9	-1.0	0.5	0.8	-1.2	-0.7	-0.5	-0.3	-0.3	-0.6	-1.3	-0.2
Patch foraging water rate 12 sec	0.2	0.7	1.9	0.6	1.0	-1.0	0.8	0.9	-1.3	-0.3	-0.8	-0.6	0.2	-0.0	-1.4	-0.8
Patch foraging water rate 18 sec	0.1	0.1	0.3	0.6	0.3	-0.3	0.2	0.3	-0.5	-0.5	-0.2	-0.1	-0.2	-0.3	-0.6	-0.1
Patch foraging water rate 24 sec	1.1	1.6	2.9	0.9	1.3	-1.4	1.3	1.4	-1.7	0.2	-1.5	-1.3	1.0	0.9	-1.6	-1.4
Patch foraging water rate 6 sec	0.8	1.2	3.9	0.5	1.0	-1.1	0.8	1.0	-1.7	-1.0	-0.9	-0.8	0.2	-0.1	-2.0	-1.4
Seeking ratio, delayed vs. immediate footshock	0.3	0.5	1.0	0.9	0.5	-0.5	0.6	0.6	-0.7	0.3	-0.6	-0.7	0.9	1.0	-0.5	-0.8
Distance traveled before self-admin	0.4	0.8	2.3	0.8	1.0	-1.1	0.9	1.0	-0.9	-0.2	-1.0	-0.9	0.6	0.5	-1.5	-0.6
Distance traveled after self-admin	0.1	0.2	0.5	0.7	0.2	-0.3	0.4	0.3	0.4	0.2	-0.3	-0.5	0.6	0.6	-0.2	0.2
Extensor digitorum longus weight	2.2	8.9	10.2	3.2	3.1	-3.1	3.2	3.2	-2.9	2.7	-3.2	-3.1	3.0	3.0	-2.6	-2.4
Bone: elastic displacement	2.0	2.5	4.3	2.1	1.7	-1.6	1.7	1.7	-1.3	2.1	-1.6	-1.6	1.6	1.6	-0.8	-0.6
Bone: elastic work	0.3	0.4	0.7	0.5	0.5	-0.6	0.5	0.6	-0.7	-0.1	-0.7	-0.6	0.6	0.6	-0.7	-0.9
Bone: endosteal estimation	0.5	1.3	4.5	0.1	0.7	-0.8	0.6	0.8	-1.5	-1.4	-0.9	-0.8	0.6	0.4	-1.9	-2.1
Bone: endosteal perimeter	0.2	0.6	2.0	-0.2	0.3	-0.4	0.2	0.3	-1.0	-1.4	-0.4	-0.3	0.1	-0.1	-1.3	-1.4
Epididymis fat weight	0.0	0.2	0.8	-0.4	0.1	-0.1	0.3	0.2	0.1	0.9	-0.3	-0.3	0.5	0.6	0.3	-0.2
Delta time in closed arm before/after self-admin	1.2	1.1	2.2	-1.5	-0.9	1.1	-0.9	-1.0	1.4	0.2	0.8	1.0	-0.8	-0.7	1.4	1.3
Delta time in open arm before/after self-admin	0.1	0.2	0.6	0.6	0.3	-0.4	0.3	0.3	-0.7	-0.3	-0.2	-0.3	0.2	0.1	-0.6	-0.5
Diff in mean of infusions in LGA sessions	0.4	0.7	1.3	0.7	1.0	-1.0	0.8	0.9	-1.0	0.0	-0.9	-0.7	0.4	0.2	-1.2	-0.8
Delay discount exponential model param	0.5	0.6	1.3	0.1	0.7	-0.7	0.8	0.7	0.0	0.9	-1.0	-0.9	1.0	1.1	-0.6	-0.9
Extinction: sum of active levers before priming	0.2	0.3	1.0	-0.3	0.1	-0.1	0.2	0.2	0.2	-0.4	-0.6	-0.6	0.9	1.0	-0.5	-0.9
Active lever presses in extinction session 6	0.9	0.9	2.3	0.5	0.6	-0.6	0.7	0.7	-1.2	0.3	-1.0	-0.9	1.1	1.1	-0.9	-1.5
Bone: final force	0.2	0.3	1.5	-0.8	-0.6	0.5	-0.6	-0.5	0.2	-1.2	0.3	0.4	-0.4	-0.4	0.0	-0.3
Bone: final moment	0.4	0.6	2.2	-1.1	-0.8	0.8	-0.9	-0.8	0.4	-1.5	0.5	0.7	-0.7	-0.7	0.2	-0.2
Food consumed during 24 hour testing period	0.6	1.3	2.3	-1.2	-1.0	1.0	-1.1	-1.1	0.9	-1.2	1.1	1.2	-1.4	-1.5	0.8	1.0
Glucose	0.2	0.3	1.0	0.1	-0.3	0.4	-0.2	-0.4	0.7	1.0	0.3	0.3	-0.1	0.1	1.0	0.9
Heart weight	0.4	0.7	1.7	0.6	0.8	-0.9	0.7	0.9	-1.1	-0.4	-0.8	-0.8	0.6	0.4	-1.3	-1.2
Delay discount hyperbolic model param	0.3	0.3	0.8	-0.1	0.4	-0.4	0.5	0.4	0.2	0.7	-0.8	-0.6	0.8	0.9	-0.4	-0.7
Intermittent access intake day 1-15 change	0.4	2.3	4.9	1.2	1.6	-1.6	1.5	1.6	-1.5	0.1	-1.5	-1.5	1.3	1.1	-2.2	-1.9
Intermittent access intake escalation	0.3	1.6	4.2	0.9	1.3	-1.3	1.1	1.3	-1.3	-0.3	-1.2	-1.2	1.0	0.8	-2.1	-1.9
Intermittent access intake escalation 2	0.1	0.2	0.9	0.5	0.4	-0.5	0.3	0.4	-0.1	-0.7	-0.4	-0.3	0.2	0.0	-1.0	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.8	2.5	-0.0	1.2	-1.2	0.9	1.1	-0.4	-0.1	-0.9	-0.9	0.5	0.3	-1.6	-0.5
Intermitt. access day 15 inactive lever presses	0.8	4.4	7.9	-1.9	-1.8	1.7	-2.1	-1.8	1.8	-2.7	2.1	2.2	-2.6	-2.8	1.0	2.0
Intermitt. access escalation Index	0.1	0.5	1.4	-0.6	-0.8	0.9	-0.6	-0.8	1.2	-0.1	0.7	0.5	-0.2	-0.1	0.9	0.5
Intermittent access day 1 total infusions	0.7	2.0	2.5	-1.6	-1.5	1.5	-1.5	-1.5	0.9	-1.0	1.6	1.5	-1.5	-1.5	1.5	1.1
Intermittent access day 15 total infusions	0.2	0.5	1.8	-0.9	-0.5	0.4	-0.6	-0.5	-0.3	-1.3	0.6	0.6	-0.8	-0.9	-0.2	-0.4
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.7	-0.4	-0.0	-0.0	-0.2	-0.1	-0.2	-0.9	0.1	0.2	-0.4	-0.5	-0.5	-0.4
Intermittent access total infusions	0.9	1.0	1.7	-1.3	-1.1	1.1	-1.1	-1.1	0.4	-1.2	1.0	1.1	-1.1	-1.1	0.8	0.3
Intermittent access day 1 locomotion	0.1	0.2	1.1	-1.0	-0.4	0.4	-0.4	-0.4	-0.4	-0.5	0.5	0.4	-0.5	-0.5	0.2	-0.3
Intermittent access day 15 total locomotion	0.6	2.3	5.3	0.7	1.5	-1.6	1.4	1.5	-2.3	0.4	-1.5	-1.4	1.2	1.0	-1.9	-2.2
Intermittent access total locomotion	0.1	0.2	0.9	-0.6	0.1	-0.2	0.1	0.1	-0.6	-0.4	-0.1	-0.2	0.1	0.1	-0.5	-1.0
Intermittent access standard deviation	0.0	0.0	0.3	0.5	0.2	-0.2	0.1	0.2	0.1	-0.0	-0.0	-0.1	-0.0	-0.0	-0.3	-0.0
Left kidney weight	2.7	21.4	32.4	-5.7	-4.9	4.9	-5.0	-4.9	4.4	-4.9	4.7	4.7	-4.5	-4.5	3.6	2.9
Right kidney weight	3.2	22.6	28.5	-5.3	-5.1	5.0	-5.1	-5.1	4.6	-4.8	4.8	4.9	-4.7	-4.7	3.9	3.3
Cocaine induced anxiety	0.2	0.5	1.5	-0.0	-0.7	0.8	-0.6	-0.7	1.2	-0.2	0.7	0.7	-0.5	-0.4	0.9	1.0
Post-drug Anxiety	0.5	0.6	2.7	1.6	0.2	-0.2	0.4	0.2	0.4	1.5	-0.1	-0.3	0.6	0.7	0.6	0.7
Baseline Anxiety	0.7	1.1	3.4	1.3	0.9	-0.9	1.1	0.9	-0.5	1.8	-0.9	-1.0	1.2	1.3	-0.2	-0.2
Tail length	1.5	8.1	13.6	-3.6	-2.7	2.6	-3.0	-2.7	2.1	-3.7	2.7	2.9	-3.3	-3.5	1.5	1.8
Length with tail	2.6	11.4	17.4	-4.2	-3.4	3.3	-3.6	-3.4	3.1	-3.9	3.3	3.4	-3.5	-3.6	2.3	2.2
Length without tail	0.5	2.7	3.9	-1.5	-1.6	1.6	-1.7	-1.7	2.0	-1.1	1.7	1.7	-1.6	-1.6	1.6	1.7
Times rat made contact with spout	0.1	0.1	0.5	-0.1	0.0	0.0	-0.1	-0.1	0.3	0.1	0.3	0.3	-0.5	-0.6	0.2	0.7
Lifetime Intake	2.5	3.1	4.2	-2.1	-1.9	1.9	-2.0	-1.9	1.1	-1.9	1.8	1.9	-1.9	-1.9	1.5	0.8
Liver weight, left	0.1	0.2	1.1	-1.0	-0.1	0.1	-0.1	-0.1	-0.4	-0.7	-0.2	-0.1	0.2	0.2	-0.4	-1.0
Liver weight, right	0.1	0.1	0.6	-0.8	-0.2	0.2	-0.3	-0.2	0.1	-0.3	0.4	0.3	-0.5	-0.6	0.1	0.3
Locomotor activity	1.1	1.6	2.2	-1.3	-1.3	1.3	-1.4	-1.3	1.2	-1.3	1.3	1.4	-1.4	-1.5	0.9	1.1
Locomotor testing distance	0.1	0.3	0.9	-0.5	-0.6	0.5	-0.6	-0.6	0.4	-1.0	0.6	0.6	-0.7	-0.7	0.1	0.2
Locomotor testing rearing	0.2	0.8	1.6	-0.9	-0.9	0.9	-1.0	-0.9	0.6	-1.3	0.9	0.9	-1.0	-1.0	0.3	0.2
Locomotion in novel chamber	1.6	2.1	6.6	-1.2	-1.6	1.6	-1.5	-1.5	2.6	-1.3	1.1	1.3	-1.1	-1.0	1.3	1.3
Locomotion in novel chamber post-restriction	0.3	1.0	2.3	0.7	0.8	-0.8	0.9	0.9	-1.0	0.1	-1.1	-1.0	1.1	1.1	-1.2	-1.5
Fecal boli incidents, locomotor time 1	0.5	1.3	1.9	-0.8	-1.1	1.1	-1.2	-1.1	0.6	-0.8	1.3	1.3	-1.4	-1.4	1.4	1.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.5	0.2	-0.2	0.2	0.2	0.3	0.5	0.1	-0.2	0.2	0.2	-0.0	0.3
Time >=10cm from walls, locomotor time 1	4.8	6.0	7.4	-2.7	-2.6	2.6	-2.6	-2.6	2.6	-2.6	2.5	2.5	-2.3	-2.3	2.0	1.7
Bouts of movement, locomotor time 1	2.7	3.5	4.5	-1.8	-2.1	2.1	-2.0	-2.1	2.1	-1.4	2.0	1.9	-1.7	-1.5	2.0	1.5
Total resting periods, locomotor time 1	2.6	3.0	4.3	-1.7	-1.9	1.9	-1.8	-1.9	2.1	-1.1	1.8	1.7	-1.5	-1.3	2.0	1.5
Rest time, locomotor task time 1	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.1	-0.1	0.4	0.6	0.1	0.1	-0.1	-0.0	0.6	0.5
Distance moved, locomotor task time 1	1.7	4.8	5.9	1.9	2.2	-2.2	2.3	2.3	-1.8	1.4	-2.3	-2.4	2.4	2.4	-2.3	-2.3
Vertical activity count, locomotor time 1	0.0	0.1	1.0	-0.1	-0.1	0.0	-0.2	-0.1	0.2	-1.0	0.2	0.1	-0.3	-0.4	-0.6	0.0
Time >=10cm from walls, locomotor time 2	0.5	1.3	2.9	-0.9	-1.1	1.1	-1.1	-1.1	1.7	-0.5	1.3	1.1	-0.9	-0.9	1.3	1.6
Bouts of movement, locomotor time 2	0.1	0.3	1.1	-1.0	-0.4	0.3	-0.5	-0.4	0.3	-1.0	0.2	0.3	-0.5	-0.5	-0.3	0.0
Total resting periods, locomotor time 2	0.1	0.3	1.2	-1.1	-0.5	0.4	-0.6	-0.5	0.4	-1.1	0.3	0.4	-0.5	-0.5	-0.2	-0.1
Rest time, locomotor task time 2	0.3	0.6	1.1	-1.0	-0.9	0.9	-0.8	-0.9	0.7	-0.4	0.8	0.7	-0.5	-0.5	0.9	0.3
Distance moved, locomotor task time 2	1.4	1.9	2.5	1.2	1.5	-1.5	1.5	1.5	-1.1	1.0	-1.6	-1.5	1.4	1.3	-1.5	-1.2
Vertical activity count, locomotor time 2	0.1	0.3	1.2	0.1	-0.3	0.3	-0.4	-0.4	0.8	-0.4	0.6	0.5	-0.6	-0.7	0.4	1.1
Light reinforcement 1	0.1	0.4	1.3	0.5	0.8	-0.9	0.7	0.8	-0.8	-0.2	-0.5	-0.6	0.2	0.0	-1.1	-0.5
Light reinforcement 2	0.2	0.5	1.5	1.1	0.7	-0.7	0.7	0.7	-0.2	1.2	-0.3	-0.6	0.6	0.6	-0.1	0.3
Bone: marrow area	0.5	1.3	4.6	0.2	0.8	-0.9	0.7	0.9	-1.6	-1.3	-1.0	-0.9	0.6	0.4	-1.9	-2.1
Bone: maximum diameter	0.5	1.0	3.9	-1.2	-0.9	0.9	-1.0	-0.9	0.4	-2.0	0.8	0.9	-1.1	-1.2	0.1	-0.0
Bone: maximum force	0.3	0.5	2.5	-0.3	0.1	-0.2	0.1	0.2	-0.8	-1.2	-0.5	-0.4	0.4	0.3	-1.0	-1.6
Bone: maximum moment	0.2	0.4	2.1	-0.7	-0.1	0.0	-0.1	-0.0	-0.6	-1.5	-0.3	-0.1	0.1	0.0	-0.9	-1.4
Mean time between licks in bursts	0.0	0.1	0.6	0.2	-0.1	0.1	0.0	-0.1	0.4	0.8	0.2	0.1	0.0	0.1	0.5	0.6
Mean num. licks in bursts	0.0	0.1	0.4	-0.3	-0.2	0.2	-0.2	-0.2	0.2	-0.6	0.2	0.1	-0.1	-0.1	-0.1	-0.2
Cd content in liver	1.8	2.0	2.7	-1.7	-1.3	1.3	-1.5	-1.4	1.3	-1.5	1.4	1.5	-1.6	-1.6	1.0	1.0
Co content in liver	0.4	0.4	0.9	-0.4	-0.7	0.8	-0.6	-0.7	1.0	-0.1	0.7	0.6	-0.5	-0.4	0.8	0.7
Cu content in liver	1.3	1.6	2.1	1.0	1.3	-1.3	1.3	1.3	-1.5	0.8	-1.4	-1.3	1.3	1.2	-1.3	-1.4
Fe content in liver	2.0	2.5	3.6	1.8	1.9	-1.9	1.7	1.8	-1.9	1.0	-1.5	-1.5	1.2	1.0	-1.8	-1.1
K content in liver	0.2	0.2	0.9	0.4	-0.1	0.1	-0.1	-0.1	0.3	0.2	0.2	0.3	-0.4	-0.5	0.4	0.9
Mg content in liver	0.4	0.5	1.6	-0.1	-0.5	0.5	-0.5	-0.6	0.8	0.1	0.6	0.7	-0.7	-0.7	0.9	1.3
Mn content in liver	0.1	0.1	0.5	0.7	-0.1	0.1	0.1	-0.0	0.5	0.6	0.0	-0.0	0.2	0.3	0.5	0.5
Na content in liver	0.1	0.1	0.5	0.7	0.3	-0.2	0.3	0.3	-0.3	0.4	-0.3	-0.3	0.3	0.4	-0.2	-0.1
Rb content in liver	1.9	2.2	3.6	1.6	1.9	-1.9	1.7	1.8	-1.6	1.2	-1.3	-1.5	1.1	0.9	-1.6	-0.8
Se content in liver	0.2	0.2	0.4	0.4	0.4	-0.5	0.4	0.4	-0.6	-0.3	-0.6	-0.4	0.2	0.1	-0.6	-0.4
Sr content in liver	0.1	0.1	0.3	-0.2	0.3	-0.3	0.2	0.3	-0.4	-0.3	-0.0	-0.2	0.0	-0.0	-0.6	-0.4
Zn content in liver	0.2	0.3	0.6	-0.7	-0.4	0.4	-0.5	-0.4	0.4	-0.7	0.4	0.6	-0.7	-0.8	0.3	0.5
Bone: minimum diameter	0.9	1.8	4.8	0.4	1.1	-1.2	1.0	1.2	-1.8	-0.7	-1.3	-1.2	0.9	0.8	-2.1	-2.2
Time in familiar zone, hab. session 1	0.1	0.1	0.5	-0.3	-0.2	0.2	-0.3	-0.2	0.1	-0.7	0.3	0.3	-0.4	-0.5	-0.1	0.1
Time in novel zone, hab. session 1	0.2	0.2	0.6	0.5	0.4	-0.4	0.4	0.4	-0.2	0.8	-0.5	-0.4	0.5	0.5	0.0	0.0
Total zone transitions, hab. session 1	0.9	1.3	1.9	1.4	1.1	-1.1	1.2	1.1	-0.9	1.4	-1.1	-1.2	1.3	1.3	-0.7	-0.7
Total locomotion distance, hab. session 1	0.6	0.8	1.0	0.9	1.0	-1.0	1.0	1.0	-0.9	0.7	-1.0	-0.9	0.9	0.8	-0.8	-0.7
Locomotion velocity, hab. session 1	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	0.5	-0.3	0.6	-0.5	-0.5	0.5	0.5	-0.3	-0.2
Time in familiar zone, hab. session 2	0.7	0.8	4.6	-1.3	-0.3	0.1	-0.5	-0.2	-0.4	-2.1	0.3	0.4	-0.8	-1.1	-0.9	-0.7
Time in novel zone, hab. session 2	1.3	1.5	3.3	1.7	1.1	-1.0	1.3	1.1	-0.8	1.8	-1.2	-1.2	1.4	1.5	-0.4	-0.4
Total zone transitions, hab. session 2	1.4	1.8	2.4	1.1	1.5	-1.5	1.5	1.5	-1.5	1.2	-1.4	-1.4	1.2	1.1	-1.4	-1.2
Total locomotion distance, hab. session 2	1.2	1.6	2.6	0.7	1.4	-1.4	1.3	1.4	-1.6	0.6	-1.4	-1.3	1.0	0.9	-1.5	-1.4
Locomotion velocity, hab. session 2	0.5	0.6	1.0	0.4	1.0	-1.0	0.8	0.9	-1.0	0.5	-0.9	-0.8	0.6	0.5	-0.9	-0.7
Novel to familiar place preference ratio	0.3	0.4	1.7	0.1	-0.4	0.4	-0.4	-0.4	0.6	0.2	0.4	0.6	-0.7	-0.7	0.8	1.3
Novelty place preference	0.2	0.2	1.3	0.2	-0.1	0.2	-0.2	-0.2	0.4	0.4	0.3	0.4	-0.5	-0.5	0.6	1.1
Time in novel zone, NPP test	0.1	0.1	0.9	0.2	-0.0	0.0	-0.1	-0.1	0.3	0.3	0.2	0.3	-0.5	-0.5	0.4	0.9
Total zone transitions, NPP test	1.9	2.9	4.5	1.6	1.5	-1.5	1.7	1.6	-1.5	1.8	-1.8	-1.8	2.0	2.1	-1.2	-1.7
Total locomotion distance, NPP test	4.1	5.7	7.3	1.8	2.4	-2.4	2.4	2.4	-2.7	1.6	-2.7	-2.5	2.5	2.5	-2.3	-2.7
Locomotion velocity, NPP test	3.1	4.4	5.5	1.7	2.0	-2.0	2.1	2.1	-2.2	1.8	-2.3	-2.2	2.3	2.3	-1.8	-2.2
Intraocular pressure	4.3	7.1	9.4	-2.3	-3.1	3.1	-2.9	-3.0	3.1	-2.3	2.7	2.7	-2.3	-2.1	2.7	2.1
Delta distance traveled before/after self-admin	0.4	0.4	1.2	-0.4	-0.7	0.7	-0.6	-0.6	1.1	-0.2	0.7	0.5	-0.3	-0.3	1.0	0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.6	0.1	-0.1	0.1	-0.0	-0.1	0.8	0.3	0.2	0.1	-0.0	0.0	0.6	0.7
Parametrial fat weight	1.5	3.4	6.3	-1.1	-1.9	2.0	-1.7	-1.9	2.5	-0.1	2.1	1.8	-1.4	-1.2	2.5	2.4
Pavlov. Cond. lever latency	0.5	0.7	1.1	0.9	1.0	-1.0	0.9	1.0	-0.9	0.4	-0.7	-0.8	0.6	0.5	-1.1	-0.7
Pavlov. Cond. magazine entry latency	0.4	0.6	1.9	-1.4	-0.7	0.7	-0.8	-0.7	0.4	-0.8	0.6	0.7	-0.8	-0.9	0.4	0.3
Pavlov. Cond. change in total contacts	0.4	0.4	0.7	-0.8	-0.7	0.7	-0.7	-0.7	0.7	-0.3	0.6	0.7	-0.6	-0.6	0.7	0.6
Pavlov. Cond. index score	1.4	1.8	2.6	-1.6	-1.4	1.4	-1.4	-1.4	1.3	-0.8	1.3	1.4	-1.3	-1.2	1.4	1.2
Pavlov. Cond. latency score	1.5	1.9	3.1	-1.7	-1.5	1.5	-1.5	-1.5	1.3	-1.0	1.3	1.4	-1.3	-1.2	1.4	1.1
Pavlov. Cond. lever contacts	1.0	1.2	1.6	-1.2	-1.2	1.2	-1.2	-1.2	1.1	-0.7	1.0	1.1	-0.9	-0.8	1.2	0.9
Pavlov. Cond. magazine entry number	0.4	0.6	1.2	1.1	0.7	-0.8	0.8	0.8	-0.7	0.4	-0.7	-0.8	0.7	0.7	-0.7	-0.7
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.9	1.4	1.0	-1.0	1.0	1.0	-0.7	1.2	-1.0	-0.9	0.9	0.9	-0.6	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.7	1.0	-1.0	-0.8	0.9	-0.8	-0.9	0.9	-0.2	0.8	0.9	-0.8	-0.7	1.0	0.9
Pavlov. Cond. response bias	0.9	1.1	1.4	-1.2	-1.1	1.1	-1.1	-1.1	1.1	-0.5	1.0	1.1	-1.0	-1.0	1.2	1.1
Pavlov. Cond. lever latency	0.6	0.8	2.2	-0.3	-0.9	1.0	-0.7	-0.9	1.4	0.6	0.9	0.6	-0.2	-0.0	1.5	1.1
Pavlov. Cond. magazine entry latency	0.4	0.6	1.5	0.2	0.9	-1.0	0.7	0.9	-1.2	-0.3	-0.7	-0.6	0.2	-0.0	-1.2	-0.7
Pavlov. Cond. change in total contacts	0.4	0.9	5.0	-1.3	-0.3	0.1	-0.6	-0.3	-0.5	-2.2	0.2	0.5	-1.0	-1.3	-0.9	-0.6
Pavlov. Cond. index score	0.5	0.8	2.7	-0.0	0.9	-1.0	0.6	0.9	-1.4	-1.0	-0.8	-0.5	0.0	-0.3	-1.6	-1.1
Pavlov. Cond. latency score	0.5	0.8	2.3	0.2	0.9	-1.0	0.7	0.9	-1.3	-0.7	-0.8	-0.6	0.1	-0.1	-1.5	-1.0
Pavlov. Cond. lever contacts	0.6	0.8	2.4	0.1	0.8	-0.9	0.6	0.8	-1.4	-0.8	-0.9	-0.6	0.2	-0.0	-1.6	-1.3
Pavlov. Cond. magazine entry number	0.9	1.2	3.5	-0.2	-1.2	1.3	-0.9	-1.1	1.6	0.8	1.1	0.8	-0.3	-0.0	1.9	1.3
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.5	-0.6	-0.6	0.6	-0.6	-0.6	0.7	-0.1	0.6	0.6	-0.5	-0.5	0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	2.3	-0.2	0.8	-0.9	0.5	0.7	-1.3	-1.1	-0.7	-0.4	-0.1	-0.4	-1.5	-1.0
Pavlov. Cond. response bias	0.9	1.2	3.7	-0.0	1.0	-1.1	0.7	1.0	-1.7	-1.1	-1.1	-0.7	0.2	-0.1	-1.9	-1.6
Time in closed arm before self-admin	0.1	0.2	0.7	0.9	0.2	-0.2	0.4	0.3	-0.1	0.6	-0.4	-0.4	0.5	0.6	0.1	-0.0
Time in closed arm after self-admin	1.7	1.9	3.2	1.0	1.3	-1.2	1.4	1.3	-0.9	1.7	-1.7	-1.5	1.7	1.8	-0.8	-1.1
Time in open arm before self-admin	0.3	0.4	2.6	-1.6	-0.4	0.4	-0.5	-0.4	0.1	-1.1	0.1	0.3	-0.3	-0.3	-0.2	-0.6
Time in open arm after self-admin	0.1	0.1	0.6	-0.2	-0.0	0.0	-0.1	-0.0	-0.4	-0.8	0.2	0.0	-0.2	-0.2	-0.5	-0.4
Bone: periosteal estimation	0.3	0.7	3.0	-0.6	0.2	-0.3	0.0	0.2	-1.0	-1.7	-0.4	-0.3	0.0	-0.1	-1.4	-1.6
Bone: periosteal perimeter	0.1	0.2	0.9	-0.3	-0.0	-0.0	-0.0	0.0	-0.5	-0.9	-0.1	-0.1	0.0	-0.1	-0.6	-0.8
Bone: post-yield work	0.2	0.4	2.0	0.0	0.2	-0.3	0.3	0.3	-0.8	-0.8	-0.6	-0.5	0.5	0.4	-0.9	-1.4
Progressive ratio test 1 active lever presses	1.8	3.2	5.7	-2.4	-1.8	1.8	-1.9	-1.8	1.2	-1.9	1.9	1.8	-1.9	-1.9	1.3	1.0
Progressive ratio test 1 breakpoint	1.7	2.8	5.5	-2.4	-1.7	1.6	-1.8	-1.7	1.1	-1.9	1.8	1.7	-1.8	-1.9	1.2	0.9
Progressive ratio test 1 inactive lever presses	1.0	2.6	6.7	-2.4	-1.5	1.4	-1.7	-1.4	0.9	-2.6	1.5	1.5	-1.8	-1.9	0.4	0.3
Progressive ratio test 2 active lever presses	1.0	1.4	2.1	-1.0	-1.2	1.2	-1.3	-1.2	0.9	-1.4	1.3	1.3	-1.4	-1.4	0.9	0.8
Progressive ratio test 2 breakpoint	1.5	1.9	2.7	-1.2	-1.4	1.4	-1.5	-1.4	1.1	-1.6	1.5	1.5	-1.6	-1.6	1.0	0.9
Progressive ratio test 2 inactive lever presses	0.1	0.4	1.1	-0.5	-0.6	0.5	-0.7	-0.6	0.4	-1.1	0.7	0.7	-0.8	-0.9	0.3	0.3
Incentive Sensitization - Responses	0.0	0.1	0.5	0.2	-0.1	0.0	-0.1	-0.0	-0.1	-0.7	0.1	0.1	-0.3	-0.4	-0.2	-0.3
Incentive Sensitization - Breakpoint	0.0	0.1	0.5	0.2	-0.1	0.1	-0.2	-0.1	-0.0	-0.7	0.2	0.2	-0.4	-0.5	-0.2	-0.2
Sum of active levers in priming session hrs 5-6	2.6	2.5	4.5	1.7	1.7	-1.8	1.5	1.7	-1.8	0.2	-1.6	-1.5	1.2	1.0	-2.1	-1.6
Progressive ratio	0.2	0.5	1.3	-0.2	-0.4	0.4	-0.6	-0.5	0.2	-0.7	0.8	0.8	-1.1	-1.2	0.3	0.7
Food seeking constrained by brief footshock	0.6	0.8	1.8	-0.9	-1.0	1.0	-1.0	-1.0	0.3	-1.3	0.8	0.9	-0.9	-0.9	0.6	0.2
Seeking ratio, punishment vs. effort	0.1	0.1	0.6	-0.5	-0.3	0.3	-0.1	-0.2	0.1	-0.2	-0.2	-0.2	0.5	0.6	0.1	-0.8
Retroperitoneal fat weight	0.7	3.1	4.3	-2.1	-1.9	1.9	-1.8	-1.9	2.1	-0.7	1.8	1.8	-1.5	-1.3	2.1	1.7
Reaction time number correct	1.7	6.0	7.0	2.3	2.4	-2.4	2.5	2.4	-2.6	1.5	-2.6	-2.6	2.6	2.6	-2.3	-2.6
Reaction time mean minus median	0.1	0.7	2.0	-0.3	0.7	-0.8	0.5	0.7	-1.3	-0.5	-0.8	-0.6	0.3	0.1	-1.4	-1.4
Reaction time mean minus median AUC	0.1	0.5	1.4	-0.2	0.6	-0.6	0.5	0.6	-1.0	0.0	-0.8	-0.6	0.5	0.5	-0.9	-1.2
Reaction time num false alarms	1.0	1.7	3.7	0.3	1.5	-1.6	1.3	1.5	-1.8	-0.0	-1.3	-1.2	0.7	0.4	-1.9	-1.4
Reaction time num false alarms AUC	0.2	0.3	1.0	-0.2	0.8	-0.9	0.5	0.7	-0.9	-0.3	-0.5	-0.4	-0.1	-0.3	-1.0	-0.3
Reaction time trials correct on left	1.7	6.0	7.0	2.3	2.4	-2.4	2.5	2.4	-2.6	1.5	-2.6	-2.6	2.6	2.6	-2.3	-2.6
Reaction time trials on left	1.5	5.2	6.4	2.1	2.2	-2.2	2.3	2.3	-2.5	1.4	-2.5	-2.4	2.4	2.4	-2.2	-2.5
Reaction time mean	0.7	1.5	3.3	-1.7	-1.2	1.1	-1.3	-1.2	0.8	-1.8	1.1	1.2	-1.4	-1.5	0.5	0.5
Reaction time mean AUC	0.6	1.4	2.5	-1.4	-1.2	1.1	-1.3	-1.2	0.9	-1.6	1.1	1.2	-1.3	-1.4	0.7	0.7
Median of all reaction times	1.9	2.9	3.9	-1.9	-1.7	1.7	-1.8	-1.7	1.5	-2.0	1.6	1.8	-1.9	-1.9	1.2	1.2
Reaction time omissions	2.0	3.3	4.0	-1.8	-2.0	2.0	-2.0	-2.0	1.9	-1.5	1.7	1.9	-1.8	-1.7	1.7	1.5
Reaction time false alarm rate	0.3	0.4	1.5	-1.0	-0.2	0.1	-0.4	-0.2	0.2	-0.7	0.6	0.6	-1.0	-1.2	0.0	0.8
Reaction time premature initiation rate	1.8	2.8	4.7	-1.0	-1.7	1.7	-1.6	-1.7	2.1	-0.5	1.9	1.7	-1.6	-1.5	2.0	2.2
Reaction time premature initiations	0.1	0.3	0.8	0.1	-0.6	0.6	-0.5	-0.6	0.8	0.2	0.6	0.5	-0.3	-0.2	0.9	0.8
Std. dev. reaction times	0.1	0.3	1.6	-1.0	-0.2	0.2	-0.4	-0.2	-0.2	-1.2	0.1	0.3	-0.6	-0.7	-0.5	-0.5
Reaction time trials completed	1.5	5.2	6.4	2.1	2.2	-2.2	2.3	2.3	-2.5	1.4	-2.5	-2.4	2.4	2.4	-2.2	-2.5
Reaction time trials AUC	1.4	4.9	6.0	2.0	2.2	-2.2	2.2	2.2	-2.4	1.3	-2.4	-2.3	2.4	2.3	-2.1	-2.4
Run reversals in cocaine runway, females	2.0	2.2	4.3	0.4	1.5	-1.6	1.5	1.5	-2.1	0.9	-1.4	-1.5	1.3	1.2	-1.6	-2.0
Run reversals in cocaine runway, males	0.3	0.3	0.6	0.6	0.5	-0.5	0.5	0.5	-0.6	0.3	-0.6	-0.6	0.6	0.6	-0.6	-0.8
Latency to leave start box in cocaine runway	6.8	9.4	12.6	2.5	3.2	-3.3	3.1	3.2	-3.6	2.0	-3.2	-3.2	2.9	2.8	-3.4	-3.1
Latency to leave start box in cocaine runway, F	4.6	5.8	8.3	2.2	2.4	-2.5	2.4	2.5	-2.9	1.5	-2.5	-2.5	2.3	2.2	-2.5	-2.5
Latency to leave start box in cocaine runway, M	3.6	3.4	5.1	1.4	2.1	-2.1	2.0	2.1	-1.8	1.4	-1.9	-2.0	1.7	1.6	-2.3	-1.4
Std. dev. time between licks in bursts	0.1	0.1	0.4	-0.3	-0.1	0.1	-0.2	-0.2	0.3	-0.5	0.4	0.3	-0.5	-0.6	0.0	0.5
Total sessions with >9 infusions	5.3	6.6	8.0	-2.5	-2.8	2.7	-2.8	-2.8	1.8	-2.3	2.8	2.8	-2.8	-2.8	2.5	1.9
Short access day 1 total inactive lever presses	0.4	0.7	1.3	-0.3	-0.8	0.7	-0.9	-0.8	0.6	-0.8	1.0	1.0	-1.1	-1.2	0.7	0.9
Short access day 10 total inactive lever presses	0.4	2.7	4.4	1.4	1.9	-2.0	1.8	1.9	-1.5	0.7	-1.7	-1.7	1.4	1.1	-2.1	-1.2
Short access day 1 total infusions	1.9	3.8	4.4	-1.8	-2.1	2.0	-2.0	-2.0	2.0	-1.7	2.1	2.0	-1.9	-1.9	1.9	1.7
Short access day 10 total infusions	3.6	6.0	7.3	-2.7	-2.6	2.6	-2.7	-2.6	1.4	-2.3	2.6	2.6	-2.6	-2.6	2.2	1.6
Short access total infusions	6.2	8.8	10.8	-3.2	-3.3	3.3	-3.3	-3.3	2.2	-2.8	3.1	3.2	-3.0	-2.9	2.7	1.9
Short access day 1 locomotion	1.5	2.4	5.3	-2.3	-1.5	1.4	-1.6	-1.5	1.2	-2.1	1.5	1.5	-1.7	-1.8	0.8	0.6
Short access day 10 total locomotion	0.1	0.2	1.1	-0.1	-0.0	0.1	0.0	-0.1	0.4	1.1	0.4	0.2	-0.1	0.0	0.8	0.9
Short access total locomotion	1.5	2.2	2.8	-1.6	-1.5	1.5	-1.5	-1.5	1.0	-0.9	1.7	1.6	-1.7	-1.6	1.6	1.3
One hour access (0.3 mA shock)	0.1	0.1	0.4	0.0	0.1	-0.1	-0.1	0.1	-0.6	-0.6	0.1	0.1	-0.4	-0.5	-0.4	-0.5
Compulsive drug intake	0.1	0.2	0.9	1.0	-0.2	0.2	-0.1	-0.2	0.6	0.0	0.4	0.2	-0.1	-0.1	0.3	0.5
One hour access (shock baseline)	0.1	0.1	0.4	-0.6	-0.2	0.2	-0.3	-0.2	-0.2	-0.7	0.2	0.3	-0.4	-0.5	-0.1	-0.3
Social response proportion	2.7	3.5	4.4	-2.1	-1.8	1.9	-1.9	-1.9	2.1	-0.9	1.9	2.0	-1.9	-1.8	1.9	1.8
Social responses	1.6	2.1	2.8	-1.7	-1.4	1.4	-1.5	-1.5	1.5	-0.8	1.4	1.5	-1.6	-1.5	1.4	1.4
Social time	0.4	0.6	1.2	0.2	0.8	-0.8	0.7	0.8	-0.9	0.1	-0.7	-0.7	0.5	0.4	-1.1	-1.1
Soleus weight	1.6	4.9	7.6	2.8	2.4	-2.4	2.4	2.4	-2.1	2.3	-2.2	-2.2	2.1	2.0	-1.7	-1.3
Bone: stiffness	0.3	0.5	1.9	-0.0	0.4	-0.5	0.4	0.5	-0.8	-0.4	-0.6	-0.6	0.6	0.5	-1.0	-1.4
Tibialis anterior weight	0.3	1.1	1.3	1.1	1.1	-1.0	1.1	1.1	-1.0	1.1	-1.1	-1.1	1.1	1.1	-0.8	-0.9
Time to tail flick, vehicle, before self-admin	1.1	1.3	1.9	1.0	1.1	-1.0	1.2	1.1	-1.3	1.3	-1.1	-1.2	1.3	1.4	-0.7	-0.9
Time to tail flick, vehicle, after self-admin	1.2	2.5	3.7	0.8	1.7	-1.7	1.7	1.7	-1.4	1.3	-1.9	-1.7	1.6	1.5	-1.6	-1.6
Time to tail flick, test, before self-admin	0.3	0.4	1.0	1.0	0.7	-0.7	0.7	0.7	-0.2	0.7	-0.6	-0.6	0.6	0.6	-0.6	-0.2
Time to tail flick, test, after self-admin	1.7	1.8	3.7	0.9	1.4	-1.4	1.3	1.4	-1.9	1.1	-1.2	-1.3	1.1	1.1	-1.3	-1.6
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.2	0.2	-0.2	0.2	0.2	0.1	0.3	-0.2	-0.1	0.1	0.1	-0.0	-0.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.5	0.1	-0.1	0.1	0.1	-0.6	0.3	-0.0	-0.1	0.1	0.1	-0.0	-0.4
Tibia length	4.6	12.8	22.8	-4.5	-3.8	3.7	-3.9	-3.7	2.7	-4.8	3.3	3.6	-3.7	-3.8	2.0	1.5
Ambulatory time before self-admin	0.1	0.4	1.5	0.3	0.6	-0.6	0.5	0.6	-0.6	-0.6	-0.7	-0.5	0.3	0.2	-1.2	-0.5
Ambulatory time after self-admin	0.1	0.1	0.2	0.4	0.3	-0.3	0.3	0.3	0.2	-0.1	-0.4	-0.3	0.3	0.3	-0.3	0.2
Bone: tissue strength	0.3	0.3	0.4	-0.3	-0.6	0.6	-0.6	-0.6	0.7	-0.5	0.6	0.6	-0.5	-0.5	0.6	0.5
Total heroin consumption	0.8	0.9	3.9	2.0	1.0	-1.0	0.9	1.0	-0.6	0.4	-0.9	-0.8	0.7	0.6	-0.9	-0.4
Bone: trabecular number	0.5	0.9	1.6	0.8	0.8	-0.9	0.9	0.9	-1.2	0.3	-1.0	-1.0	1.0	1.0	-1.1	-1.3
Bone: trabecular spacing	0.6	0.9	1.2	-0.9	-1.1	1.1	-1.0	-1.1	1.0	-0.7	0.9	1.0	-0.9	-0.8	1.0	0.8
Bone: trabecular thickness	0.1	0.1	0.5	-0.7	-0.1	0.0	-0.1	-0.0	-0.4	-0.7	-0.1	-0.0	-0.0	-0.1	-0.4	-0.7
Bone: trabecular tissue density	0.7	1.3	4.1	-1.7	-1.0	0.9	-1.1	-1.0	0.5	-2.0	0.9	1.0	-1.2	-1.3	0.1	0.1
Water consumed over 24 hours	0.2	0.4	0.9	0.7	1.0	-0.9	0.8	0.8	-0.6	0.9	-0.5	-0.5	0.2	0.1	-0.5	0.3
Number of responses in last shaping day	1.7	2.2	3.3	-1.8	-1.5	1.5	-1.5	-1.5	1.4	-1.1	1.7	1.5	-1.4	-1.4	1.4	1.3