C15h13orf42

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	C15h13orf42	0.06	0.03	8.5e-15	0.09	0.09	0.08	0.09	5.1e-13	2.0e-13	1.1e-12	5.1e-13
2	Brain	gene expression	C15h13orf42	0.14	0.07	5.8e-13	0.12	0.15	0.15	0.14	1.1e-11	8.2e-14	1.2e-13	1.8e-13
3	pVTA	gene expression	C15h13orf42	0.17	0.07	0.0e+00	0.26	0.26	0.28	0.27	3.2e-21	5.4e-21	3.0e-22	3.5e-22
4	BLA	gene expression	C15h13orf42	0.14	0.07	9.5e-08	0.14	0.12	0.12	0.13	7.0e-08	8.7e-07	5.7e-07	1.4e-07
5	LHb	gene expression	C15h13orf42	0.24	0.13	1.7e-04	0.11	0.08	0.07	0.1	1.8e-03	5.6e-03	8.2e-03	2.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.2	0.3	0.5	0.5	0.7	-0.6	-0.3	-0.5
Area under the delay curve	2.6	4.0	4.2	-2.1	-2.0	2.0	2.0	1.9
BMI with tail	1.2	4.3	4.8	-2.0	-2.1	2.1	1.9	2.2
BMI without tail	0.0	0.3	0.4	-0.5	-0.6	0.5	0.5	0.3
Body weight	1.5	6.5	7.1	-2.7	-2.5	2.5	2.6	2.4
Weight adjusted by age	0.7	2.2	2.5	-1.6	-1.5	1.3	1.5	1.5
Bone surface	0.3	0.6	0.9	0.7	0.9	-0.8	-0.5	-0.8
Bone volume	0.2	0.3	0.6	0.6	0.8	-0.6	-0.2	-0.6
Breakpoint value in progressive ratio session	0.4	0.8	1.0	-1.0	-1.0	0.6	0.9	0.8
Number of licking bursts	0.1	0.2	0.4	-0.3	-0.4	0.4	0.7	0.5
Context. condit. distance diff. score	0.1	0.1	0.3	0.5	0.5	-0.3	-0.3	-0.3
Locomotion velocity, session 1	1.5	1.7	2.3	-1.4	-1.5	1.2	1.2	1.2
Locomotion distance, session 1	1.2	1.5	1.7	-1.3	-1.3	1.1	1.3	1.2
Locomotion velocity, session 2	0.5	0.6	1.5	-0.7	-0.3	0.7	1.2	0.7
Locomotion distance, session 2	0.1	0.1	0.5	-0.3	-0.0	0.1	0.7	0.3
Locomotion velocity, session 3	1.3	1.5	2.1	-1.1	-1.0	1.2	1.5	1.3
Locomotion distance, session 3	1.3	1.5	2.9	-1.2	-1.0	1.0	1.7	1.0
Stereotopy head waving bouts, day 3	0.8	1.0	1.3	1.1	1.0	-0.9	-1.2	-0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.2	-0.3	0.3	-0.1	0.5
Locomotion velocity, session 7	0.1	0.1	0.2	0.3	0.5	-0.2	0.4	-0.5
Locomotion distance, session 7	1.9	2.5	3.0	1.6	1.7	-1.6	-1.2	-1.6
Stereotopy head waving bouts, day 7	3.1	3.6	4.1	-1.9	-1.9	2.0	1.7	2.0
Stereotopy head waving duration, day 7	4.6	5.7	6.4	-2.3	-2.3	2.5	2.2	2.5
Locomotion velocity, session 8	0.5	0.6	1.7	-0.6	-0.3	0.6	1.3	0.7
Locomotion distance, session 8	0.1	0.1	0.4	-0.2	-0.1	0.2	0.6	0.4
Degree of sensitization distance	7.5	8.1	9.2	2.9	2.8	-2.7	-3.0	-2.7
Degree of sensitization stereotypy	3.7	4.2	4.5	-2.1	-2.1	2.1	1.9	2.0
Conditioned locomotion	0.6	0.7	1.0	0.9	1.0	-1.0	-0.4	-0.6
Cocaine response after cond. corrected	0.2	0.3	0.4	0.6	0.6	-0.5	-0.3	-0.6
Cocaine response after cond. not corrected	0.2	0.2	0.3	0.5	0.5	-0.4	-0.2	-0.6
Cocaine response before conditioning	0.5	0.6	0.8	-0.9	-0.9	0.8	0.7	0.6
Saline control response	0.1	0.1	0.2	0.2	0.1	-0.2	-0.5	-0.4
Bone: connectivity density	0.6	1.0	1.3	1.0	1.1	-1.1	-0.8	-1.0
Bone: cortical apparent density	1.0	1.6	2.1	-1.2	-1.5	1.4	0.9	1.3
Bone: cortical area	0.0	0.0	0.0	-0.1	0.1	0.2	0.2	-0.0
Bone: cortical porosity	1.7	1.8	2.4	-1.4	-1.2	1.4	1.6	1.1
Bone: cortical porosity	1.7	1.9	2.2	-1.5	-1.4	1.4	1.5	1.1
Bone: cortical thickness	0.4	0.7	1.0	-0.8	-0.8	1.0	0.7	0.7
Bone: cortical thickness	1.5	1.8	2.0	-1.3	-1.3	1.4	1.4	1.2
Bone: cortical tissue density	0.9	1.5	2.0	-1.1	-1.4	1.4	0.8	1.3
Condit. Reinf. active minus inactive responses	1.6	1.9	2.7	-1.6	-1.6	1.2	1.0	1.3
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	-0.2	-0.3	-0.0	-0.3	0.1
Condit. Reinf. active responses	2.5	3.2	5.1	-2.1	-2.2	1.6	1.3	1.6
Condit. Reinf. inactive responses	1.4	1.9	2.8	-1.6	-1.7	1.1	1.1	1.2
Incentive salience index mean	3.1	4.0	5.2	-2.2	-2.3	1.8	1.7	1.9
Condit. Reinf. lever presses	3.6	5.4	6.6	-2.6	-2.6	2.1	2.0	2.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	-0.5	-0.8	0.3	0.1	0.2
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.7	-0.7	-0.9	0.7	0.3	0.7
Condit. Reinf. active responses	0.4	0.5	1.1	-0.8	-1.0	0.6	0.5	0.7
Condit. Reinf. inactive responses	0.3	0.4	0.5	0.6	0.5	-0.7	-0.6	-0.6
Condit. Reinf. lever presses	3.8	5.5	6.7	-2.4	-2.5	2.2	2.0	2.6
Condit. Reinf. lever reinforcers received	0.7	1.0	1.8	-1.0	-1.3	0.9	0.6	0.9
Conditioned reinforcement - actives	2.4	9.7	11.4	3.0	2.9	-3.2	-3.4	-3.1
Conditioned reinforcement - inactives	2.9	7.9	8.9	2.9	3.0	-2.8	-2.7	-2.7
Conditioned locomotion	2.3	3.5	4.5	1.8	1.6	-1.8	-2.1	-2.0
Patch foraging indifference point 0 sec	0.0	0.1	0.3	0.3	0.5	-0.3	-0.2	-0.2
Patch foraging indifference point AUC	0.0	0.1	0.2	0.3	0.2	0.0	-0.4	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	-0.3	0.4	0.4	0.4
Delay disc. indifference point, 16s delay	0.5	0.8	1.0	-0.9	-0.9	0.8	1.0	0.7
Delay disc. indifference point, 2s delay	1.9	2.1	2.4	-1.4	-1.5	1.5	1.3	1.5
Delay disc. indifference point, 24s delay	0.4	0.6	0.7	-0.8	-0.8	0.8	0.8	0.7
Delay disc. indifference point, 4s delay	3.9	4.2	4.9	-2.2	-2.1	2.0	2.0	1.9
Delay disc. indifference point, 8s delay	1.7	2.9	3.1	-1.7	-1.6	1.7	1.8	1.7
Indifference point function ln k	0.1	0.3	0.5	-0.7	-0.5	0.5	0.7	0.1
Indifference point function log k	0.1	0.3	0.5	-0.7	-0.5	0.5	0.7	0.1
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	-0.2	0.0	0.2	0.3	0.3
Patch foraging total patch changes 12 sec	0.5	0.6	1.3	-0.7	-0.7	0.8	0.6	1.1
Patch foraging total patch changes 18 sec	0.1	0.2	0.5	-0.3	-0.4	0.4	0.1	0.7
Patch foraging total patch changes 24 sec	0.3	1.1	2.7	-0.8	-0.8	0.8	0.9	1.7
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	0.1	0.1	0.1	-0.1	0.3
Patch foraging time to switch 0 sec	0.0	0.2	0.3	0.5	0.5	-0.6	-0.1	-0.3
Patch foraging water rate 0 sec	0.3	1.2	1.6	-1.3	-1.2	1.2	1.1	0.8
Patch foraging water rate 12 sec	1.1	4.5	5.7	-2.4	-2.4	1.9	2.2	1.7
Patch foraging water rate 18 sec	4.0	9.0	10.5	-3.2	-3.1	2.9	3.2	2.6
Patch foraging water rate 24 sec	0.9	1.3	2.0	-1.4	-1.4	1.0	1.0	0.8
Patch foraging water rate 6 sec	2.4	3.6	4.1	-2.0	-2.0	1.7	1.9	1.7
Seeking ratio, delayed vs. immediate footshock	1.3	1.9	2.9	1.3	1.5	-1.4	-0.9	-1.7
Distance traveled before self-admin	0.1	0.3	0.3	-0.5	-0.5	0.6	0.4	0.6
Distance traveled after self-admin	0.1	0.1	0.3	0.2	0.3	-0.3	-0.5	-0.5
Extensor digitorum longus weight	7.8	31.3	34.4	-5.5	-5.3	5.9	5.7	5.5
Bone: elastic displacement	0.3	0.4	0.7	0.7	0.8	-0.8	-0.3	-0.6
Bone: elastic work	0.1	0.2	0.3	-0.4	-0.3	0.3	0.4	0.6
Bone: endosteal estimation	0.6	1.4	2.0	1.2	1.4	-1.2	-0.9	-1.2
Bone: endosteal perimeter	1.1	2.8	3.4	1.6	1.8	-1.8	-1.4	-1.6
Epididymis fat weight	0.0	0.1	0.2	-0.3	-0.4	0.4	0.3	0.2
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.1	-0.0	0.3	-0.0	0.4
Delta time in open arm before/after self-admin	1.6	1.9	2.1	1.4	1.4	-1.4	-1.4	-1.4
Diff in mean of infusions in LGA sessions	0.2	0.3	0.6	-0.5	-0.2	0.4	0.7	0.8
Delay discount exponential model param	4.1	5.5	5.9	2.4	2.3	-2.4	-2.3	-2.3
Extinction: sum of active levers before priming	0.1	0.2	0.3	-0.4	-0.5	0.3	0.3	0.5
Active lever presses in extinction session 6	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.0	0.3
Bone: final force	0.8	1.4	1.8	-1.1	-1.0	1.3	1.1	1.3
Bone: final moment	1.1	1.7	2.1	-1.2	-1.1	1.5	1.2	1.5
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.5	-0.5	0.5	0.5	0.3
Glucose	0.1	0.2	0.4	-0.4	-0.4	0.4	0.5	0.6
Heart weight	0.1	0.2	0.5	-0.5	-0.7	0.3	0.0	0.1
Delay discount hyperbolic model param	3.8	4.9	5.2	2.3	2.2	-2.3	-2.2	-2.1
Intermittent access intake day 1-15 change	0.4	2.0	2.7	1.5	1.4	-1.4	-1.6	-1.0
Intermittent access intake escalation	0.2	1.2	1.7	1.2	1.1	-1.1	-1.3	-0.7
Intermittent access intake escalation 2	0.5	0.8	0.9	1.0	0.9	-0.9	-0.9	-0.6
Intermitt. access day 1 inactive lever presses	0.7	9.4	10.5	3.1	3.2	-3.1	-3.0	-2.9
Intermitt. access day 15 inactive lever presses	0.5	2.5	2.8	1.5	1.7	-1.6	-1.6	-1.4
Intermitt. access escalation Index	0.0	0.1	0.2	-0.3	-0.3	0.4	0.4	0.5
Intermittent access day 1 total infusions	0.5	1.4	1.6	1.3	1.2	-1.2	-1.1	-1.1
Intermittent access day 15 total infusions	1.5	3.7	4.3	2.1	2.0	-2.0	-2.0	-1.6
Intermittent access terminal intake (last 3 days)	2.3	4.0	4.7	2.2	2.2	-2.0	-2.0	-1.6
Intermittent access total infusions	4.5	5.3	5.9	2.4	2.4	-2.3	-2.3	-2.0
Intermittent access day 1 locomotion	0.2	0.4	0.5	0.6	0.7	-0.7	-0.4	-0.7
Intermittent access day 15 total locomotion	0.6	2.4	2.8	1.7	1.7	-1.5	-1.6	-1.2
Intermittent access total locomotion	1.5	1.8	2.1	1.4	1.3	-1.4	-1.5	-1.2
Intermittent access standard deviation	0.2	0.8	1.0	0.9	0.9	-1.0	-1.0	-0.7
Left kidney weight	1.0	7.9	9.1	-3.0	-2.9	2.6	2.8	2.7
Right kidney weight	2.1	14.9	16.8	-4.1	-4.1	3.7	3.7	3.7
Cocaine induced anxiety	0.4	1.0	1.2	-1.0	-1.0	1.1	0.9	0.9
Post-drug Anxiety	0.0	0.0	0.1	-0.2	-0.1	0.3	0.2	0.2
Baseline Anxiety	0.1	0.1	0.1	0.3	0.3	-0.3	-0.4	-0.4
Tail length	0.0	0.2	0.3	-0.5	-0.6	0.3	0.4	0.1
Length with tail	0.0	0.1	0.3	-0.4	-0.2	0.2	0.5	0.1
Length without tail	0.4	1.9	2.3	-1.4	-1.1	1.3	1.5	1.5
Times rat made contact with spout	0.4	0.4	0.7	-0.6	-0.5	0.6	0.9	0.6
Lifetime Intake	4.5	5.6	6.1	2.5	2.4	-2.4	-2.4	-2.1
Liver weight, left	2.4	4.1	5.7	-2.2	-2.4	1.9	1.4	2.1
Liver weight, right	0.1	0.1	0.2	-0.4	-0.4	0.3	0.4	0.1
Locomotor activity	3.6	5.7	6.7	-2.5	-2.3	2.4	2.6	2.1
Locomotor testing distance	0.1	0.1	0.3	-0.4	-0.2	0.4	0.6	0.1
Locomotor testing rearing	0.0	0.1	0.2	-0.4	-0.3	0.3	0.5	0.2
Locomotion in novel chamber	2.0	2.7	3.0	-1.6	-1.7	1.7	1.7	1.5
Locomotion in novel chamber post-restriction	0.0	0.1	0.2	0.0	0.4	0.1	0.5	0.0
Fecal boli incidents, locomotor time 1	1.2	3.0	3.5	-1.7	-1.7	1.9	1.7	1.7
Change in fecal boli incidents, locomotor task	1.2	1.2	2.1	1.2	1.5	-1.1	-0.6	-1.0
Time >=10cm from walls, locomotor time 1	0.1	0.2	0.3	-0.4	-0.3	0.4	0.3	0.5
Bouts of movement, locomotor time 1	0.5	0.6	1.0	-0.8	-0.6	0.8	1.0	0.7
Total resting periods, locomotor time 1	0.4	0.5	0.7	-0.7	-0.5	0.7	0.8	0.6
Rest time, locomotor task time 1	1.5	2.4	2.5	-1.6	-1.6	1.6	1.4	1.6
Distance moved, locomotor task time 1	0.6	1.7	2.0	1.4	1.3	-1.4	-1.1	-1.3
Vertical activity count, locomotor time 1	0.2	1.1	1.4	1.1	1.1	-1.2	-0.7	-1.2
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.2	0.4	-0.4	-0.2	0.0
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.4	-0.2	0.3	0.5	0.2
Total resting periods, locomotor time 2	0.1	0.3	0.5	-0.6	-0.4	0.6	0.7	0.5
Rest time, locomotor task time 2	1.7	2.9	3.1	-1.8	-1.7	1.6	1.7	1.7
Distance moved, locomotor task time 2	0.2	0.3	0.5	0.6	0.4	-0.7	-0.6	-0.4
Vertical activity count, locomotor time 2	0.3	0.7	1.0	0.8	0.5	-0.8	-0.9	-1.0
Light reinforcement 1	0.2	1.1	1.9	-1.0	-0.8	1.1	1.4	0.9
Light reinforcement 2	0.5	1.1	2.0	1.1	1.1	-0.9	-0.6	-1.4
Bone: marrow area	0.6	1.5	2.1	1.3	1.5	-1.2	-0.9	-1.3
Bone: maximum diameter	0.7	1.4	1.8	1.2	1.4	-1.1	-0.7	-1.3
Bone: maximum force	0.6	1.1	1.7	-1.0	-0.8	1.2	1.0	1.3
Bone: maximum moment	0.8	1.5	2.2	-1.2	-1.1	1.4	1.1	1.5
Mean time between licks in bursts	0.1	0.4	0.6	0.7	0.5	-0.7	-0.8	-0.6
Mean num. licks in bursts	0.0	0.0	0.1	-0.2	-0.2	0.0	-0.1	-0.1
Cd content in liver	0.3	0.3	0.4	-0.6	-0.6	0.6	0.5	0.4
Co content in liver	0.6	0.7	1.0	-0.8	-0.6	0.9	1.0	1.0
Cu content in liver	2.0	2.3	2.9	-1.5	-1.4	1.6	1.5	1.7
Fe content in liver	0.8	1.0	1.7	1.0	0.9	-0.9	-1.0	-1.3
K content in liver	0.2	0.2	0.4	0.6	0.7	-0.3	-0.4	0.1
Mg content in liver	1.8	1.9	2.5	1.5	1.6	-1.4	-1.4	-1.1
Mn content in liver	1.1	1.3	1.7	1.3	1.2	-1.0	-1.3	-0.7
Na content in liver	2.2	2.4	3.5	-1.5	-1.5	1.5	1.4	1.9
Rb content in liver	3.1	3.6	4.5	2.0	2.1	-1.7	-1.8	-1.8
Se content in liver	2.6	3.1	3.9	1.7	1.8	-1.8	-1.4	-2.0
Sr content in liver	0.5	0.4	0.6	0.6	0.5	-0.8	-0.7	-0.7
Zn content in liver	0.1	0.1	0.2	0.3	0.4	-0.5	-0.3	0.1
Bone: minimum diameter	0.2	0.4	0.6	0.6	0.8	-0.5	-0.4	-0.7
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.5	-0.7	0.6	-0.0	0.5
Time in novel zone, hab. session 1	0.3	0.3	0.7	0.7	0.8	-0.5	0.0	-0.5
Total zone transitions, hab. session 1	0.8	1.1	1.6	-0.9	-0.9	1.0	1.3	1.1
Total locomotion distance, hab. session 1	0.1	0.2	0.5	-0.2	-0.2	0.3	0.4	0.7
Locomotion velocity, hab. session 1	0.2	0.3	0.7	-0.5	-0.5	0.5	0.5	0.9
Time in familiar zone, hab. session 2	0.4	0.5	0.8	0.6	0.5	-0.6	-0.8	-0.9
Time in novel zone, hab. session 2	0.3	0.3	0.7	-0.4	-0.3	0.4	0.8	0.7
Total zone transitions, hab. session 2	2.7	3.4	4.8	-1.8	-1.6	1.6	2.2	2.0
Total locomotion distance, hab. session 2	1.5	2.0	3.1	-1.2	-1.0	1.2	1.8	1.7
Locomotion velocity, hab. session 2	1.7	2.2	3.1	-1.4	-1.2	1.3	1.8	1.7
Novel to familiar place preference ratio	1.3	1.7	2.3	1.3	1.5	-1.5	-1.1	-1.2
Novelty place preference	1.2	1.6	2.2	1.2	1.5	-1.4	-1.0	-1.1
Time in novel zone, NPP test	1.2	1.5	2.0	1.2	1.4	-1.3	-0.9	-1.1
Total zone transitions, NPP test	1.3	1.9	2.2	-1.4	-1.3	1.2	1.5	1.5
Total locomotion distance, NPP test	0.0	0.0	0.1	0.1	0.2	-0.3	0.1	0.3
Locomotion velocity, NPP test	0.0	0.1	0.3	0.0	0.1	-0.1	0.1	0.5
Intraocular pressure	2.2	3.7	5.8	1.7	1.5	-1.9	-2.0	-2.4
Delta distance traveled before/after self-admin	2.0	2.2	3.0	1.3	1.3	-1.4	-1.6	-1.7
Delta ambulatory time before/after self-admin	0.9	1.5	1.9	1.1	1.1	-1.2	-1.4	-1.3
Parametrial fat weight	1.5	3.6	4.3	1.8	1.9	-2.1	-1.7	-2.1
Pavlov. Cond. lever latency	1.3	1.6	2.2	1.5	1.5	-1.1	-1.2	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.0	-0.1	-0.2	-0.5	-0.2
Pavlov. Cond. change in total contacts	0.4	0.5	0.8	-0.9	-0.8	0.6	0.5	0.5
Pavlov. Cond. index score	1.7	2.2	2.9	-1.7	-1.7	1.4	1.4	1.2
Pavlov. Cond. latency score	1.4	1.8	2.5	-1.6	-1.6	1.2	1.2	1.1
Pavlov. Cond. lever contacts	1.0	1.2	1.8	-1.3	-1.3	0.9	1.0	0.9
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	1.1	1.2	-0.9	-0.6	-0.9
Pavlov. Cond. intertrial magazine entries	1.6	1.9	2.4	-1.4	-1.5	1.4	1.1	1.3
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	2.9	-1.7	-1.7	1.4	1.3	1.3
Pavlov. Cond. response bias	1.2	1.5	2.1	-1.4	-1.4	1.1	0.9	1.1
Pavlov. Cond. lever latency	3.8	5.4	6.6	2.3	2.3	-2.2	-2.2	-2.6
Pavlov. Cond. magazine entry latency	1.4	2.0	2.3	-1.5	-1.5	1.4	1.2	1.3
Pavlov. Cond. change in total contacts	2.7	6.7	7.6	-2.5	-2.6	2.5	2.5	2.8
Pavlov. Cond. index score	3.5	5.6	6.1	-2.4	-2.5	2.3	2.2	2.5
Pavlov. Cond. latency score	3.3	5.3	5.9	-2.4	-2.4	2.2	2.1	2.4
Pavlov. Cond. lever contacts	3.9	5.8	7.2	-2.4	-2.4	2.3	2.3	2.7
Pavlov. Cond. magazine entry number	2.0	2.6	2.9	1.6	1.7	-1.6	-1.6	-1.5
Pavlov. Cond. intertrial magazine entries	1.6	3.5	4.1	1.9	1.8	-2.0	-1.7	-1.9
Pavlov. Cond. lever-magazine prob. diff.	3.4	5.3	5.9	-2.3	-2.4	2.2	2.1	2.4
Pavlov. Cond. response bias	4.4	6.1	6.6	-2.5	-2.5	2.4	2.4	2.6
Time in closed arm before self-admin	0.6	1.0	1.7	-0.9	-0.7	1.0	1.3	0.9
Time in closed arm after self-admin	2.1	2.4	3.1	-1.5	-1.3	1.8	1.6	1.6
Time in open arm before self-admin	0.1	0.1	0.2	-0.5	-0.5	0.4	0.3	0.3
Time in open arm after self-admin	0.6	0.7	0.8	0.9	0.8	-0.8	-0.9	-0.8
Bone: periosteal estimation	0.4	1.0	1.5	1.0	1.2	-0.9	-0.7	-1.1
Bone: periosteal perimeter	0.3	0.7	0.9	0.8	0.9	-0.8	-0.6	-0.9
Bone: post-yield work	0.0	0.0	0.1	0.1	0.1	0.2	0.0	0.2
Progressive ratio test 1 active lever presses	0.9	1.6	1.7	1.3	1.3	-1.3	-1.3	-1.2
Progressive ratio test 1 breakpoint	0.8	1.4	1.5	1.2	1.2	-1.2	-1.2	-1.1
Progressive ratio test 1 inactive lever presses	1.0	2.5	2.8	1.7	1.6	-1.7	-1.5	-1.4
Progressive ratio test 2 active lever presses	2.2	3.1	3.6	1.9	1.9	-1.8	-1.8	-1.4
Progressive ratio test 2 breakpoint	2.0	2.6	3.0	1.7	1.7	-1.6	-1.6	-1.3
Progressive ratio test 2 inactive lever presses	1.2	3.9	4.4	2.1	2.0	-2.0	-2.0	-1.7
Incentive Sensitization - Responses	0.6	1.6	1.9	1.4	1.3	-1.3	-1.3	-0.9
Incentive Sensitization - Breakpoint	0.6	1.4	1.7	1.3	1.3	-1.3	-1.2	-0.9
Sum of active levers in priming session hrs 5-6	0.2	0.1	0.2	0.3	0.2	-0.4	-0.5	-0.4
Progressive ratio	0.1	0.3	0.3	-0.6	-0.6	0.4	0.5	0.4
Food seeking constrained by brief footshock	0.4	0.4	0.5	0.7	0.5	-0.7	-0.7	-0.7
Seeking ratio, punishment vs. effort	0.0	0.0	0.1	0.2	0.1	-0.1	-0.3	-0.1
Retroperitoneal fat weight	0.0	0.0	0.1	0.2	0.3	-0.2	-0.1	-0.2
Reaction time number correct	0.0	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.3
Reaction time mean minus median	0.0	0.0	0.1	-0.2	-0.3	0.1	-0.2	0.2
Reaction time mean minus median AUC	0.0	0.0	0.1	-0.1	-0.2	0.1	-0.3	0.2
Reaction time num false alarms	0.3	0.5	0.7	-0.7	-0.5	0.8	0.7	0.8
Reaction time num false alarms AUC	0.5	1.1	1.4	-1.0	-0.8	1.2	1.0	1.1
Reaction time trials correct on left	0.0	0.1	0.1	0.3	0.3	-0.1	-0.1	-0.3
Reaction time trials on left	0.0	0.1	0.2	0.4	0.3	-0.1	-0.2	-0.4
Reaction time mean	0.3	0.8	1.4	0.6	0.6	-1.0	-1.2	-0.9
Reaction time mean AUC	0.4	0.9	1.5	0.7	0.7	-1.0	-1.2	-1.0
Median of all reaction times	0.7	1.1	1.7	0.7	0.7	-1.1	-1.3	-1.1
Reaction time omissions	1.6	2.7	3.7	1.7	1.5	-1.5	-1.9	-1.6
Reaction time false alarm rate	0.8	1.1	1.3	-1.0	-0.8	1.1	1.1	1.1
Reaction time premature initiation rate	0.3	0.5	0.6	-0.6	-0.5	0.8	0.7	0.8
Reaction time premature initiations	0.0	0.1	0.2	-0.2	-0.2	0.5	0.4	0.3
Std. dev. reaction times	0.1	0.5	0.9	0.6	0.5	-0.8	-0.9	-0.5
Reaction time trials completed	0.0	0.1	0.2	0.4	0.3	-0.1	-0.2	-0.4
Reaction time trials AUC	0.0	0.1	0.2	0.4	0.4	-0.2	-0.2	-0.4
Run reversals in cocaine runway, females	1.3	1.5	2.0	1.1	1.1	-1.1	-1.4	-1.4
Run reversals in cocaine runway, males	0.9	1.0	1.2	-1.0	-1.1	1.1	0.6	1.1
Latency to leave start box in cocaine runway	0.8	1.1	1.4	1.0	1.1	-1.0	-1.0	-1.2
Latency to leave start box in cocaine runway, F	1.9	2.3	2.5	1.5	1.6	-1.5	-1.5	-1.6
Latency to leave start box in cocaine runway, M	0.3	0.3	0.4	-0.5	-0.5	0.7	0.6	0.4
Std. dev. time between licks in bursts	1.6	3.0	4.1	1.7	1.6	-1.8	-2.0	-1.4
Total sessions with >9 infusions	2.7	3.4	4.0	1.7	1.7	-2.0	-2.0	-1.8
Short access day 1 total inactive lever presses	0.0	0.0	0.0	0.0	0.0	-0.1	-0.2	-0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.3	0.4	0.3	-0.5	-0.5	-0.5
Short access day 1 total infusions	2.5	5.0	5.1	2.2	2.2	-2.3	-2.2	-2.2
Short access day 10 total infusions	0.6	1.0	1.1	1.0	1.0	-1.1	-1.0	-1.0
Short access total infusions	2.6	3.6	4.0	1.9	1.9	-1.9	-2.0	-1.8
Short access day 1 locomotion	0.2	0.4	0.5	0.5	0.5	-0.7	-0.7	-0.7
Short access day 10 total locomotion	0.1	0.3	0.6	-0.7	-0.8	0.4	0.2	0.4
Short access total locomotion	0.0	0.1	0.1	-0.1	-0.2	-0.3	-0.4	-0.2
One hour access (0.3 mA shock)	2.2	2.6	3.2	1.7	1.5	-1.6	-1.8	-1.5
Compulsive drug intake	1.3	1.9	2.2	-1.4	-1.5	1.5	1.4	1.0
One hour access (shock baseline)	2.1	5.4	6.0	2.4	2.4	-2.4	-2.5	-2.0
Social response proportion	2.8	3.5	4.3	1.8	1.8	-1.9	-1.7	-2.1
Social responses	1.6	2.0	2.6	1.4	1.2	-1.4	-1.5	-1.6
Social time	0.6	1.0	1.9	-0.9	-0.8	1.0	1.4	0.8
Soleus weight	0.6	1.8	2.6	-1.3	-1.6	1.6	1.0	1.2
Bone: stiffness	0.2	0.4	0.6	-0.5	-0.3	0.8	0.7	0.8
Tibialis anterior weight	8.5	29.1	32.0	-5.3	-5.1	5.6	5.7	5.3
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	0.3	0.4	-0.0	-0.3	-0.1
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.3	0.1	0.3	0.1	0.5	0.3
Time to tail flick, test, before self-admin	0.7	0.8	1.1	-0.7	-0.8	1.0	0.8	1.0
Time to tail flick, test, after self-admin	2.6	2.7	3.1	1.7	1.5	-1.6	-1.7	-1.8
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	0.0	0.0	0.5	0.3
Delta time to tail flick, test, before/after SA	2.6	3.2	4.0	1.7	1.6	-1.9	-1.7	-2.0
Tibia length	0.7	2.0	2.7	-1.5	-1.3	1.3	1.6	1.4
Ambulatory time before self-admin	0.3	0.8	0.9	-0.9	-0.9	1.0	0.9	0.9
Ambulatory time after self-admin	0.1	0.2	0.4	-0.6	-0.5	0.5	0.5	0.3
Bone: tissue strength	0.2	0.2	0.5	0.4	0.3	-0.5	-0.7	-0.4
Total heroin consumption	0.8	0.9	1.6	-1.1	-1.3	0.8	0.7	0.8
Bone: trabecular number	0.6	1.1	1.4	0.9	1.1	-1.2	-0.7	-1.2
Bone: trabecular spacing	0.3	0.5	0.7	-0.6	-0.7	0.8	0.6	0.6
Bone: trabecular thickness	0.7	0.9	1.4	-1.0	-0.8	0.9	1.2	1.0
Bone: trabecular tissue density	0.8	1.5	1.7	-1.2	-1.3	1.3	1.2	1.1
Water consumed over 24 hours	0.1	0.2	0.4	-0.5	-0.4	0.4	0.6	0.3
Number of responses in last shaping day	0.4	0.5	0.8	0.7	0.8	-0.9	-0.7	-0.5