Hub : Genes

Btf3l4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver mRNA stability Btf3l4 0.02 0.02 9.8e-03 0.01 0 0 0 3.6e-02 1.6e-01 2.1e-01 2.4e-01
2 Adipose alternative polyA NM_001399000.1 0.03 0.02 4.5e-03 0.01 0.01 0 0.01 2.0e-02 3.6e-02 9.9e-02 4.3e-02
3 Adipose alternative polyA XM_063288112.1 0.03 0.02 3.0e-03 0.01 0.01 0 0.01 1.6e-02 2.5e-02 1.8e-01 3.3e-02
4 Adipose isoform ratio XM_039111512.2 0.03 0.02 1.1e-03 0.02 0.01 0.01 0.01 2.5e-03 1.1e-02 1.2e-02 1.1e-02
5 pVTA gene expression Btf3l4 0.05 0.05 1.0e-03 0.03 0.03 0.02 0.02 3.6e-03 2.0e-03 1.9e-02 5.7e-03
6 PL alternative TSS NM_001399000.1 0.03 0.02 3.0e-03 0.02 0.01 0.01 0.01 4.4e-03 4.6e-02 6.4e-02 2.6e-02
7 NAcc gene expression Btf3l4 0.06 0.04 2.1e-09 0.06 0.06 0.06 0.06 2.8e-09 1.2e-09 4.2e-09 2.3e-09
8 Adipose gene expression Btf3l4 0.06 0.04 6.5e-06 0.03 0.03 0.03 0.03 2.3e-04 4.4e-04 7.2e-04 6.6e-04
9 Liver intron excision ratio chr5_128808007_128815448 0.08 0.05 4.8e-08 0.04 0.04 0.04 0.04 6.8e-05 3.2e-05 2.8e-05 6.8e-05
10 OFC isoform ratio XM_039111512.2 0.15 0.11 4.5e-03 -0 0.07 0.05 0.03 3.6e-01 9.9e-03 2.2e-02 8.6e-02
11 Liver gene expression Btf3l4 0.12 0.07 4.6e-11 0.07 0.07 0.07 0.07 8.2e-08 1.4e-08 6.2e-08 2.1e-08
12 OFC alternative polyA NM_001399000.1 0.19 0.13 1.1e-03 0.07 0.11 0.11 0.09 1.0e-02 1.4e-03 1.3e-03 4.0e-03
13 OFC alternative polyA XM_063288112.1 0.19 0.13 1.2e-03 0.02 0.11 0.11 0.09 1.2e-01 1.7e-03 1.3e-03 4.8e-03
14 Brain gene expression Btf3l4 0.04 0.03 7.0e-04 0 0.02 0.02 0.02 9.9e-02 7.5e-03 5.0e-03 1.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.61.01.21.01.0-1.0-1.0-1.1-1.1-1.1-1.11.10.9-0.9-1.01.0-1.1
Area under the delay curve0.10.10.3-0.1-0.10.10.10.10.20.1-0.1-0.1-0.50.50.5-0.50.4
BMI with tail0.93.24.8-2.1-2.12.12.12.22.02.22.0-2.0-1.01.11.1-1.11.3
BMI without tail0.51.62.4-1.4-1.41.41.41.51.51.51.4-1.4-0.90.90.9-0.91.0
Body weight0.52.23.4-1.7-1.71.71.71.81.61.81.6-1.7-0.91.01.0-1.01.1
Weight adjusted by age0.10.10.2-0.4-0.40.40.40.50.40.50.3-0.40.2-0.2-0.20.2-0.1
Bone surface0.10.20.30.50.5-0.5-0.5-0.5-0.5-0.5-0.50.50.2-0.2-0.30.3-0.4
Bone volume0.00.00.10.20.2-0.2-0.2-0.2-0.2-0.2-0.20.20.1-0.1-0.20.2-0.2
Breakpoint value in progressive ratio session0.00.00.10.20.2-0.2-0.2-0.2-0.2-0.2-0.20.20.2-0.2-0.20.2-0.2
Number of licking bursts0.00.10.3-0.1-0.10.10.10.20.20.20.2-0.10.3-0.3-0.40.4-0.5
Context. condit. distance diff. score0.70.91.11.01.0-1.0-1.0-0.8-0.8-0.8-0.80.90.9-0.9-0.90.9-1.0
Locomotion velocity, session 14.54.85.32.32.3-2.3-2.3-2.2-2.2-2.1-2.22.22.1-2.1-2.22.2-2.3
Locomotion distance, session 10.20.20.60.40.4-0.4-0.4-0.4-0.4-0.4-0.40.40.6-0.6-0.70.7-0.8
Locomotion velocity, session 24.04.75.02.22.2-2.2-2.2-2.1-2.2-2.1-2.22.22.1-2.1-2.22.2-2.2
Locomotion distance, session 21.11.51.7-1.2-1.21.21.21.11.31.11.3-1.2-1.31.31.3-1.31.2
Locomotion velocity, session 30.80.91.31.11.1-1.1-1.1-1.0-0.9-1.0-0.91.00.7-0.8-0.80.8-0.9
Locomotion distance, session 30.40.40.7-0.4-0.40.40.40.50.60.40.6-0.6-0.80.80.8-0.80.8
Stereotopy head waving bouts, day 30.20.20.60.30.3-0.3-0.3-0.4-0.3-0.4-0.30.40.6-0.6-0.70.7-0.8
Stereotopy head waving duration, day 31.31.52.51.01.0-1.0-1.0-1.0-1.0-1.0-1.01.11.6-1.6-1.51.5-1.6
Locomotion velocity, session 70.20.20.60.20.2-0.2-0.20.10.30.00.3-0.1-0.80.70.7-0.70.6
Locomotion distance, session 71.01.33.1-0.7-0.70.70.70.70.90.60.9-0.8-1.81.71.6-1.61.4
Stereotopy head waving bouts, day 72.32.63.01.71.7-1.7-1.7-1.7-1.5-1.7-1.51.61.6-1.6-1.51.5-1.5
Stereotopy head waving duration, day 72.53.03.31.81.8-1.8-1.8-1.8-1.6-1.7-1.61.81.7-1.7-1.71.7-1.7
Locomotion velocity, session 81.82.22.71.61.6-1.6-1.6-1.6-1.5-1.6-1.51.61.2-1.2-1.21.2-1.3
Locomotion distance, session 80.00.00.10.30.3-0.3-0.3-0.10.0-0.10.00.1-0.00.0-0.00.0-0.2
Degree of sensitization distance0.40.40.6-0.6-0.60.60.60.50.50.50.5-0.5-0.80.80.7-0.60.5
Degree of sensitization stereotypy1.11.21.61.31.3-1.3-1.3-1.1-1.0-1.1-1.01.11.0-1.0-1.00.9-0.9
Conditioned locomotion0.20.20.70.20.2-0.2-0.2-0.1-0.2-0.1-0.20.20.8-0.7-0.80.8-0.8
Cocaine response after cond. corrected3.13.83.8-1.9-1.91.91.91.92.01.92.0-2.0-1.92.02.0-2.02.0
Cocaine response after cond. not corrected3.23.74.1-2.0-2.02.02.02.02.02.02.0-2.0-1.81.81.8-1.81.9
Cocaine response before conditioning0.10.10.20.10.1-0.1-0.1-0.0-0.1-0.0-0.10.10.5-0.4-0.40.4-0.3
Saline control response0.91.22.5-0.9-0.90.90.90.70.90.60.9-0.8-1.61.51.5-1.51.3
Bone: connectivity density0.71.01.51.11.1-1.1-1.1-1.2-1.1-1.2-1.11.20.6-0.7-0.70.7-0.9
Bone: cortical apparent density2.53.54.12.02.0-2.0-2.0-1.9-1.9-1.9-1.91.91.7-1.7-1.71.7-1.7
Bone: cortical area1.42.22.5-1.6-1.61.61.61.51.51.51.5-1.5-1.31.31.3-1.31.3
Bone: cortical porosity1.31.42.70.90.9-0.9-0.9-0.8-1.0-0.7-1.01.01.6-1.6-1.61.6-1.6
Bone: cortical porosity1.82.03.01.21.2-1.2-1.2-1.1-1.3-1.0-1.31.21.7-1.7-1.71.7-1.7
Bone: cortical thickness2.13.44.5-2.1-2.12.12.12.12.02.12.0-2.0-1.31.41.4-1.41.4
Bone: cortical thickness1.01.21.9-1.3-1.31.31.31.31.21.41.2-1.2-0.50.60.5-0.50.6
Bone: cortical tissue density2.94.04.62.22.2-2.2-2.2-2.0-2.0-2.0-2.02.01.8-1.9-1.91.8-1.8
Condit. Reinf. active minus inactive responses0.50.50.7-0.8-0.80.80.80.80.80.80.8-0.8-0.60.60.6-0.60.5
Condit. Reinf. active-inactive response ratio0.70.70.9-0.9-0.90.90.90.90.90.90.9-0.9-0.70.70.7-0.70.6
Condit. Reinf. active responses1.01.21.6-1.3-1.31.31.31.21.21.21.2-1.2-0.90.90.9-0.90.8
Condit. Reinf. inactive responses0.20.30.4-0.4-0.40.40.40.50.40.50.4-0.5-0.60.60.5-0.50.5
Incentive salience index mean1.41.82.2-1.5-1.51.51.51.51.51.51.5-1.5-1.01.01.0-1.01.0
Condit. Reinf. lever presses1.42.02.7-1.6-1.61.61.61.61.61.61.6-1.5-1.11.11.1-1.11.0
Condit. Reinf. active minus inactive responses1.11.42.1-1.1-1.11.11.11.01.10.91.1-1.0-1.41.41.4-1.41.3
Condit. Reinf. active-inactive response ratio0.40.40.8-0.6-0.60.60.60.50.50.40.5-0.5-0.90.90.9-0.90.8
Condit. Reinf. active responses0.50.70.8-0.8-0.80.80.80.80.80.70.8-0.8-0.90.90.9-0.90.8
Condit. Reinf. inactive responses0.10.20.3-0.5-0.50.50.50.50.50.60.5-0.5-0.20.20.2-0.20.2
Condit. Reinf. lever presses0.20.31.1-0.3-0.30.30.30.10.30.10.3-0.3-1.01.00.9-0.90.7
Condit. Reinf. lever reinforcers received0.50.81.1-0.8-0.80.80.80.70.80.70.8-0.8-1.01.01.0-1.00.9
Conditioned reinforcement - actives3.15.26.0-2.2-2.22.22.22.22.22.22.2-2.2-2.42.52.5-2.42.4
Conditioned reinforcement - inactives0.00.10.1-0.3-0.30.30.30.30.30.30.3-0.3-0.20.20.2-0.20.2
Conditioned locomotion1.21.61.7-1.3-1.31.31.31.21.31.21.2-1.3-1.31.31.3-1.31.3
Patch foraging indifference point 0 sec0.30.60.7-0.8-0.80.80.80.80.80.80.8-0.9-0.70.70.8-0.70.8
Patch foraging indifference point AUC0.20.20.30.50.5-0.5-0.5-0.5-0.5-0.5-0.40.50.3-0.3-0.30.3-0.4
Delay disc. indifference point, 0s delay0.10.10.20.30.3-0.3-0.3-0.3-0.0-0.3-0.40.3-0.50.40.4-0.40.3
Delay disc. indifference point, 16s delay1.21.31.6-1.2-1.21.21.21.21.31.21.1-1.2-1.01.01.0-1.01.1
Delay disc. indifference point, 2s delay0.00.00.20.20.2-0.2-0.2-0.2-0.0-0.2-0.40.2-0.10.10.0-0.00.0
Delay disc. indifference point, 24s delay0.10.10.20.30.3-0.3-0.3-0.4-0.4-0.4-0.40.30.0-0.0-0.00.0-0.1
Delay disc. indifference point, 4s delay0.10.10.1-0.2-0.20.20.20.20.30.20.1-0.2-0.40.40.3-0.30.3
Delay disc. indifference point, 8s delay0.10.10.2-0.2-0.20.20.20.10.20.10.1-0.2-0.50.50.5-0.50.4
Indifference point function ln k0.30.50.7-0.8-0.80.80.80.80.80.80.8-0.8-0.60.60.6-0.60.6
Indifference point function log k0.30.50.7-0.8-0.80.80.80.80.80.80.8-0.8-0.60.60.6-0.60.6
Patch foraging total patch changes 0 sec0.20.50.6-0.7-0.70.70.70.80.70.80.7-0.8-0.50.60.6-0.60.6
Patch foraging total patch changes 12 sec0.81.11.41.21.2-1.2-1.2-1.1-1.2-1.1-1.11.10.7-0.8-0.80.8-0.9
Patch foraging total patch changes 18 sec0.20.30.4-0.5-0.50.50.50.60.50.60.7-0.6-0.50.50.5-0.50.5
Patch foraging total patch changes 24 sec0.50.81.2-1.0-1.01.01.01.11.01.11.0-1.1-0.60.60.7-0.70.9
Patch foraging total patch changes 6 sec0.30.50.8-0.5-0.50.50.50.50.60.50.6-0.7-0.90.90.9-0.90.9
Patch foraging time to switch 0 sec1.12.22.61.61.6-1.6-1.6-1.5-1.6-1.5-1.51.51.4-1.4-1.31.3-1.3
Patch foraging water rate 0 sec1.12.33.1-1.7-1.71.71.71.71.71.81.7-1.6-1.01.11.1-1.11.2
Patch foraging water rate 12 sec1.83.74.4-2.0-2.02.02.02.12.02.12.0-2.1-1.61.71.7-1.71.9
Patch foraging water rate 18 sec0.10.10.20.20.2-0.2-0.2-0.2-0.2-0.2-0.30.30.5-0.5-0.50.5-0.4
Patch foraging water rate 24 sec0.00.10.20.10.1-0.1-0.1-0.0-0.10.0-0.10.10.4-0.4-0.40.4-0.4
Patch foraging water rate 6 sec0.91.31.7-1.2-1.21.21.21.31.21.31.3-1.3-0.80.80.9-0.91.0
Seeking ratio, delayed vs. immediate footshock2.73.34.2-1.9-1.91.91.91.91.91.92.1-1.9-1.61.61.6-1.61.6
Distance traveled before self-admin0.00.10.1-0.3-0.30.30.30.30.30.3-0.1-0.10.2-0.2-0.20.2-0.1
Distance traveled after self-admin0.60.71.1-1.0-1.01.01.01.01.01.00.7-0.9-0.40.50.5-0.40.6
Extensor digitorum longus weight0.52.03.5-1.6-1.61.61.61.81.71.91.7-1.6-0.60.70.6-0.60.7
Bone: elastic displacement0.30.30.70.40.4-0.4-0.4-0.2-0.3-0.1-0.30.30.9-0.8-0.80.8-0.8
Bone: elastic work0.00.00.1-0.2-0.20.20.20.30.20.30.2-0.20.0-0.0-0.10.1-0.1
Bone: endosteal estimation0.00.10.10.30.3-0.3-0.3-0.3-0.4-0.3-0.30.30.1-0.1-0.00.00.0
Bone: endosteal perimeter0.00.10.20.20.2-0.2-0.2-0.3-0.2-0.3-0.20.2-0.50.40.4-0.40.4
Epididymis fat weight0.00.10.10.20.2-0.2-0.2-0.2-0.3-0.2-0.20.2-0.30.30.3-0.30.3
Delta time in closed arm before/after self-admin0.00.00.0-0.1-0.10.10.10.10.10.10.1-0.1-0.20.20.2-0.20.2
Delta time in open arm before/after self-admin0.20.20.2-0.4-0.40.40.40.40.40.40.4-0.4-0.40.40.4-0.40.4
Diff in mean of infusions in LGA sessions0.30.30.7-0.4-0.40.40.40.30.40.40.4-0.4-0.90.80.8-0.80.8
Delay discount exponential model param0.10.10.30.10.1-0.1-0.1-0.1-0.2-0.10.00.10.5-0.5-0.50.5-0.5
Extinction: sum of active levers before priming0.20.20.80.10.1-0.1-0.1-0.0-0.1-0.00.10.00.9-0.8-0.80.8-0.7
Active lever presses in extinction session 62.62.63.0-1.7-1.71.71.71.61.71.61.5-1.5-1.61.71.7-1.61.7
Bone: final force0.00.00.1-0.1-0.10.10.10.00.00.00.0-0.0-0.30.30.3-0.30.2
Bone: final moment0.10.10.3-0.3-0.30.30.30.20.20.20.2-0.2-0.50.50.5-0.50.4
Food consumed during 24 hour testing period2.02.74.6-1.5-1.51.51.51.31.41.21.4-1.4-2.12.12.0-2.01.7
Glucose0.40.60.8-0.7-0.70.70.70.70.70.60.7-0.7-0.90.90.9-0.90.9
Heart weight0.50.71.4-1.0-1.01.01.01.21.01.21.0-1.00.00.10.2-0.10.4
Delay discount hyperbolic model param0.00.10.20.00.0-0.0-0.00.0-0.1-0.00.1-0.00.4-0.4-0.40.4-0.3
Intermittent access intake day 1-15 change0.61.31.5-1.1-1.11.11.11.11.11.11.2-1.2-1.21.21.2-1.21.2
Intermittent access intake escalation0.51.01.4-1.0-1.01.01.01.01.01.01.2-1.1-0.90.90.9-0.91.0
Intermittent access intake escalation 20.20.30.5-0.5-0.50.50.50.50.50.50.7-0.6-0.50.50.5-0.50.5
Intermitt. access day 1 inactive lever presses0.62.32.6-1.5-1.51.51.51.61.51.61.6-1.6-1.31.41.4-1.41.5
Intermitt. access day 15 inactive lever presses0.20.50.7-0.8-0.80.80.80.80.80.80.8-0.8-0.20.30.3-0.30.4
Intermitt. access escalation Index0.20.30.50.40.4-0.4-0.4-0.3-0.4-0.3-0.50.40.7-0.7-0.70.7-0.6
Intermittent access day 1 total infusions0.10.20.40.40.4-0.4-0.4-0.3-0.4-0.3-0.30.40.7-0.7-0.70.7-0.6
Intermittent access day 15 total infusions0.10.20.4-0.5-0.50.50.50.60.50.60.7-0.6-0.10.10.2-0.20.2
Intermittent access terminal intake (last 3 days)0.00.00.1-0.1-0.10.10.10.20.10.20.3-0.20.1-0.1-0.00.00.0
Intermittent access total infusions0.10.10.20.10.1-0.1-0.1-0.1-0.1-0.1-0.10.10.5-0.4-0.40.4-0.4
Intermittent access day 1 locomotion0.10.10.20.20.2-0.2-0.2-0.1-0.2-0.1-0.10.20.4-0.4-0.40.4-0.4
Intermittent access day 15 total locomotion0.30.50.7-0.7-0.70.70.70.60.70.60.7-0.7-0.80.80.8-0.80.8
Intermittent access total locomotion0.00.00.1-0.0-0.00.00.00.00.00.00.00.00.3-0.3-0.30.3-0.3
Intermittent access standard deviation1.63.24.1-1.9-1.91.91.91.91.91.92.0-2.0-1.51.51.6-1.61.7
Left kidney weight4.822.327.6-5.1-5.15.15.15.25.15.35.1-5.1-3.73.93.9-3.84.1
Right kidney weight2.611.815.5-3.7-3.73.73.73.93.83.93.8-3.8-2.52.62.6-2.62.8
Cocaine induced anxiety0.20.30.5-0.6-0.60.60.60.70.60.60.6-0.60.4-0.3-0.30.4-0.1
Post-drug Anxiety0.40.50.7-0.8-0.80.80.80.80.80.70.4-0.70.6-0.5-0.50.6-0.3
Baseline Anxiety0.10.10.2-0.4-0.40.40.40.40.40.40.1-0.3-0.20.30.2-0.20.2
Tail length0.00.00.10.30.3-0.3-0.3-0.1-0.2-0.1-0.10.10.1-0.1-0.20.2-0.3
Length with tail0.20.70.9-0.8-0.80.80.80.90.80.90.9-0.9-0.80.80.8-0.80.9
Length without tail1.75.56.0-2.4-2.42.42.42.42.32.42.4-2.4-2.12.22.2-2.22.4
Times rat made contact with spout1.61.93.0-1.3-1.31.31.31.11.31.11.3-1.2-1.71.71.5-1.51.2
Lifetime Intake0.00.00.00.10.1-0.1-0.1-0.0-0.1-0.0-0.00.10.1-0.1-0.10.1-0.1
Liver weight, left0.00.00.20.00.0-0.0-0.0-0.1-0.0-0.10.00.1-0.40.40.3-0.30.1
Liver weight, right0.00.00.10.00.0-0.0-0.0-0.2-0.1-0.2-0.00.2-0.30.30.2-0.20.0
Locomotor activity0.71.02.1-0.9-0.90.90.90.60.90.60.7-0.8-1.41.41.3-1.31.2
Locomotor testing distance1.22.13.4-1.3-1.31.31.31.11.31.11.2-1.2-1.81.81.8-1.81.7
Locomotor testing rearing1.12.24.2-1.2-1.21.21.21.01.21.01.1-1.2-2.12.02.0-1.91.8
Locomotion in novel chamber4.35.55.7-2.3-2.32.32.32.32.32.32.4-2.3-2.42.42.4-2.42.4
Locomotion in novel chamber post-restriction0.10.20.6-0.1-0.10.10.10.20.10.20.1-0.10.8-0.7-0.70.7-0.5
Fecal boli incidents, locomotor time 10.20.30.8-0.4-0.40.40.40.30.30.40.2-0.4-0.90.80.8-0.80.7
Change in fecal boli incidents, locomotor task0.20.20.30.50.5-0.5-0.5-0.6-0.5-0.6-0.50.50.2-0.3-0.20.3-0.3
Time >=10cm from walls, locomotor time 12.22.33.11.41.4-1.4-1.4-1.4-1.4-1.4-1.41.41.7-1.7-1.71.7-1.8
Bouts of movement, locomotor time 10.40.50.80.90.9-0.9-0.9-0.9-0.9-0.9-0.70.80.3-0.3-0.30.3-0.4
Total resting periods, locomotor time 10.40.40.60.80.8-0.8-0.8-0.7-0.7-0.7-0.60.70.4-0.4-0.40.4-0.4
Rest time, locomotor task time 10.00.00.10.10.1-0.1-0.1-0.1-0.2-0.10.10.1-0.30.30.3-0.30.3
Distance moved, locomotor task time 10.50.71.40.60.6-0.6-0.6-0.6-0.5-0.6-0.70.71.2-1.1-1.11.2-1.1
Vertical activity count, locomotor time 10.10.30.5-0.6-0.60.60.60.60.70.60.5-0.6-0.30.30.3-0.30.4
Time >=10cm from walls, locomotor time 20.10.10.30.20.2-0.2-0.2-0.2-0.2-0.2-0.20.20.6-0.5-0.60.6-0.6
Bouts of movement, locomotor time 20.81.21.61.11.1-1.1-1.1-1.0-1.2-1.0-0.81.01.2-1.2-1.21.2-1.3
Total resting periods, locomotor time 20.61.01.31.01.0-1.0-1.0-0.9-1.1-0.9-0.80.91.1-1.1-1.11.1-1.1
Rest time, locomotor task time 20.00.10.10.30.3-0.3-0.3-0.2-0.4-0.2-0.10.2-0.20.20.2-0.20.2
Distance moved, locomotor task time 20.30.40.7-0.7-0.70.70.70.80.80.70.6-0.7-0.00.10.1-0.10.2
Vertical activity count, locomotor time 21.62.12.6-1.6-1.61.61.61.51.61.51.6-1.5-1.21.21.3-1.31.3
Light reinforcement 10.00.00.1-0.1-0.10.10.10.20.10.30.1-0.20.4-0.3-0.20.3-0.1
Light reinforcement 20.61.01.5-1.1-1.11.11.11.21.21.21.1-1.1-0.50.50.5-0.50.6
Bone: marrow area0.00.00.10.20.2-0.2-0.2-0.2-0.3-0.2-0.30.20.0-0.0-0.00.00.1
Bone: maximum diameter0.00.10.1-0.3-0.30.30.30.40.30.40.3-0.3-0.10.10.1-0.10.1
Bone: maximum force0.00.10.1-0.2-0.20.20.20.10.10.10.1-0.1-0.40.40.3-0.30.2
Bone: maximum moment0.10.20.3-0.4-0.40.40.40.30.30.30.3-0.3-0.50.50.5-0.50.4
Mean time between licks in bursts0.30.71.41.01.0-1.0-1.0-1.1-1.0-1.2-1.00.90.1-0.2-0.10.1-0.1
Mean num. licks in bursts0.91.42.1-1.0-1.01.01.00.91.00.91.0-1.0-1.41.41.4-1.41.4
Cd content in liver0.40.40.60.70.7-0.7-0.7-0.8-0.7-0.8-0.70.70.4-0.4-0.40.4-0.5
Co content in liver0.00.00.1-0.1-0.10.10.10.00.10.00.1-0.1-0.30.30.3-0.30.2
Cu content in liver0.50.61.6-0.3-0.30.30.30.10.30.10.4-0.3-1.31.21.2-1.21.1
Fe content in liver0.10.10.3-0.4-0.40.40.40.50.40.60.4-0.50.1-0.1-0.00.00.1
K content in liver0.60.51.7-0.4-0.40.40.40.20.40.10.4-0.4-1.31.21.1-1.20.9
Mg content in liver3.53.55.3-1.7-1.71.71.71.51.71.41.7-1.7-2.32.32.2-2.22.1
Mn content in liver0.30.30.40.60.6-0.6-0.6-0.6-0.6-0.6-0.60.60.5-0.5-0.50.5-0.6
Na content in liver0.10.10.30.40.4-0.4-0.4-0.5-0.4-0.5-0.40.4-0.00.0-0.00.0-0.2
Rb content in liver0.20.20.5-0.3-0.30.30.30.20.30.20.3-0.3-0.70.70.7-0.70.7
Se content in liver0.10.10.3-0.1-0.10.10.10.00.1-0.00.1-0.1-0.60.60.5-0.50.5
Sr content in liver0.00.00.00.10.1-0.1-0.1-0.1-0.1-0.1-0.10.10.1-0.1-0.10.1-0.1
Zn content in liver0.20.20.60.10.1-0.1-0.1-0.3-0.1-0.4-0.10.2-0.80.70.7-0.70.5
Bone: minimum diameter1.32.33.3-1.4-1.41.41.41.31.31.21.3-1.4-1.81.81.8-1.81.8
Time in familiar zone, hab. session 10.70.70.80.90.9-0.9-0.9-0.8-0.8-0.8-0.80.80.8-0.8-0.70.8-0.7
Time in novel zone, hab. session 10.10.10.3-0.2-0.20.20.20.10.20.10.2-0.1-0.50.50.4-0.50.3
Total zone transitions, hab. session 10.40.51.40.40.4-0.4-0.4-0.6-0.6-0.5-0.60.60.9-0.9-1.01.0-1.2
Total locomotion distance, hab. session 10.10.20.5-0.1-0.10.10.10.1-0.00.1-0.00.10.7-0.7-0.70.7-0.7
Locomotion velocity, hab. session 10.10.20.5-0.0-0.00.00.0-0.0-0.10.0-0.10.10.7-0.6-0.70.7-0.7
Time in familiar zone, hab. session 20.10.10.50.00.0-0.0-0.0-0.2-0.0-0.2-0.00.0-0.70.60.6-0.60.5
Time in novel zone, hab. session 20.10.10.40.20.2-0.2-0.2-0.1-0.2-0.1-0.20.20.7-0.6-0.60.6-0.5
Total zone transitions, hab. session 20.10.20.4-0.2-0.20.20.20.30.40.20.4-0.3-0.60.60.6-0.60.5
Total locomotion distance, hab. session 20.20.30.4-0.4-0.40.40.40.60.70.60.7-0.6-0.50.50.6-0.60.6
Locomotion velocity, hab. session 20.30.40.6-0.5-0.50.50.50.70.70.70.7-0.7-0.50.50.6-0.60.6
Novel to familiar place preference ratio2.42.72.9-1.7-1.71.71.71.51.61.51.6-1.6-1.71.71.6-1.61.6
Novelty place preference1.31.51.7-1.3-1.31.31.31.11.21.11.2-1.2-1.21.21.2-1.21.1
Time in novel zone, NPP test1.11.11.3-1.1-1.11.11.11.01.01.01.0-1.0-1.11.11.1-1.11.0
Total zone transitions, NPP test0.20.30.7-0.6-0.60.60.60.80.70.80.7-0.7-0.20.20.3-0.30.4
Total locomotion distance, NPP test0.40.50.9-0.7-0.70.70.70.90.91.00.9-0.9-0.40.40.5-0.50.6
Locomotion velocity, NPP test0.71.11.7-1.1-1.11.11.11.31.21.31.2-1.2-0.60.60.7-0.70.9
Intraocular pressure0.40.60.8-0.9-0.90.90.90.70.70.70.7-0.7-0.80.80.8-0.80.8
Delta distance traveled before/after self-admin1.41.51.8-1.3-1.31.31.31.31.21.31.3-1.3-1.11.11.1-1.21.2
Delta ambulatory time before/after self-admin0.91.11.2-1.1-1.11.11.11.11.11.11.1-1.1-1.01.01.0-1.01.0
Parametrial fat weight0.00.10.20.20.2-0.2-0.2-0.3-0.3-0.2-0.30.20.4-0.4-0.30.3-0.2
Pavlov. Cond. lever latency0.91.11.71.21.2-1.2-1.2-1.3-1.3-1.3-1.31.20.5-0.5-0.50.5-0.4
Pavlov. Cond. magazine entry latency0.10.20.30.50.5-0.5-0.5-0.5-0.4-0.5-0.40.40.2-0.2-0.30.3-0.3
Pavlov. Cond. change in total contacts0.00.00.0-0.1-0.10.10.10.10.10.10.1-0.1-0.00.0-0.10.1-0.2
Pavlov. Cond. index score0.20.20.4-0.6-0.60.60.60.60.60.60.6-0.6-0.30.30.3-0.20.1
Pavlov. Cond. latency score0.30.30.6-0.7-0.70.70.70.60.80.60.8-0.6-0.40.40.3-0.30.2
Pavlov. Cond. lever contacts0.60.71.2-1.0-1.01.01.01.01.11.11.1-1.0-0.40.40.4-0.40.3
Pavlov. Cond. magazine entry number0.20.20.3-0.5-0.50.50.50.50.50.60.5-0.5-0.40.40.4-0.40.5
Pavlov. Cond. intertrial magazine entries1.72.02.7-1.4-1.41.41.41.21.31.21.3-1.3-1.51.51.6-1.61.6
Pavlov. Cond. lever-magazine prob. diff.0.30.40.6-0.7-0.70.70.70.70.80.70.8-0.7-0.40.50.4-0.40.3
Pavlov. Cond. response bias0.00.00.1-0.1-0.10.10.10.10.20.20.2-0.10.2-0.1-0.20.2-0.2
Pavlov. Cond. lever latency1.21.63.41.01.0-1.0-1.0-0.8-0.9-0.7-0.90.91.8-1.8-1.71.7-1.5
Pavlov. Cond. magazine entry latency0.50.62.0-0.1-0.10.10.1-0.10.1-0.20.1-0.1-1.41.31.2-1.21.0
Pavlov. Cond. change in total contacts0.91.53.5-0.9-0.90.90.90.60.80.50.8-0.8-1.91.81.7-1.71.5
Pavlov. Cond. index score1.01.33.8-0.6-0.60.60.60.30.60.20.6-0.6-1.91.81.7-1.81.5
Pavlov. Cond. latency score1.01.33.6-0.7-0.70.70.70.40.60.30.6-0.6-1.91.81.7-1.71.5
Pavlov. Cond. lever contacts0.81.22.6-0.8-0.80.80.80.60.80.50.8-0.8-1.61.51.5-1.51.3
Pavlov. Cond. magazine entry number0.30.41.1-0.4-0.40.40.40.60.40.80.4-0.41.1-0.9-0.80.9-0.6
Pavlov. Cond. intertrial magazine entries0.60.91.80.70.7-0.7-0.7-0.6-0.7-0.5-0.70.71.3-1.3-1.31.3-1.2
Pavlov. Cond. lever-magazine prob. diff.1.11.54.2-0.7-0.70.70.70.40.60.20.6-0.6-2.11.91.8-1.91.6
Pavlov. Cond. response bias0.60.82.3-0.4-0.40.40.40.20.40.10.4-0.4-1.51.41.3-1.41.1
Time in closed arm before self-admin0.50.70.80.80.8-0.8-0.8-0.8-0.9-0.8-0.70.80.9-0.9-0.90.9-0.9
Time in closed arm after self-admin0.40.40.50.60.6-0.6-0.6-0.5-0.6-0.6-0.50.50.7-0.7-0.70.7-0.7
Time in open arm before self-admin0.30.30.8-0.4-0.40.40.40.30.40.30.2-0.3-0.90.80.8-0.80.8
Time in open arm after self-admin1.21.31.5-1.1-1.11.11.11.11.11.11.0-1.1-1.21.21.2-1.21.2
Bone: periosteal estimation0.30.60.7-0.8-0.80.80.80.80.70.80.7-0.8-0.60.70.7-0.70.7
Bone: periosteal perimeter0.20.30.4-0.5-0.50.50.50.50.40.40.4-0.5-0.60.60.6-0.60.7
Bone: post-yield work0.00.00.00.10.1-0.1-0.1-0.1-0.2-0.1-0.10.1-0.10.10.1-0.10.1
Progressive ratio test 1 active lever presses0.40.50.8-0.8-0.80.80.80.90.80.90.9-0.8-0.30.40.4-0.40.5
Progressive ratio test 1 breakpoint0.40.50.8-0.8-0.80.80.80.90.80.90.9-0.8-0.30.40.4-0.40.5
Progressive ratio test 1 inactive lever presses0.20.30.4-0.6-0.60.60.60.60.60.60.6-0.6-0.20.20.2-0.20.3
Progressive ratio test 2 active lever presses0.30.30.6-0.7-0.70.70.70.70.70.60.8-0.7-0.20.20.2-0.30.2
Progressive ratio test 2 breakpoint0.20.30.5-0.6-0.60.60.60.60.60.60.7-0.6-0.00.10.0-0.10.1
Progressive ratio test 2 inactive lever presses0.00.10.1-0.3-0.30.30.30.30.30.30.4-0.3-0.20.20.2-0.20.2
Incentive Sensitization - Responses0.00.00.0-0.0-0.00.00.0-0.00.0-0.00.1-0.10.1-0.0-0.10.0-0.1
Incentive Sensitization - Breakpoint0.00.00.0-0.1-0.10.10.10.10.10.00.2-0.10.0-0.0-0.1-0.0-0.1
Sum of active levers in priming session hrs 5-60.10.10.2-0.1-0.10.10.10.20.20.20.2-0.10.5-0.4-0.40.4-0.3
Progressive ratio0.30.40.5-0.7-0.70.70.70.70.70.70.4-0.6-0.60.60.6-0.60.7
Food seeking constrained by brief footshock2.83.54.02.02.0-2.0-2.0-2.0-2.0-2.0-2.02.01.5-1.6-1.61.6-1.7
Seeking ratio, punishment vs. effort2.94.24.82.22.2-2.2-2.2-2.2-2.2-2.2-2.02.11.8-1.8-1.81.8-1.9
Retroperitoneal fat weight0.10.30.50.40.4-0.4-0.4-0.6-0.6-0.6-0.70.60.5-0.5-0.50.5-0.5
Reaction time number correct0.20.51.00.50.5-0.5-0.5-0.4-0.5-0.4-0.50.51.0-1.0-0.90.9-0.8
Reaction time mean minus median0.41.12.9-0.5-0.50.50.50.40.50.30.4-0.5-1.71.61.6-1.61.4
Reaction time mean minus median AUC0.20.61.6-0.3-0.30.30.30.20.30.10.2-0.3-1.31.21.2-1.21.1
Reaction time num false alarms2.02.83.6-1.6-1.61.61.61.51.61.51.6-1.6-1.91.91.8-1.81.8
Reaction time num false alarms AUC3.04.65.4-2.1-2.12.12.12.02.12.02.1-2.1-2.32.32.3-2.32.3
Reaction time trials correct on left0.20.51.00.50.5-0.5-0.5-0.4-0.5-0.4-0.50.51.0-1.0-0.90.9-0.8
Reaction time trials on left0.20.40.70.50.5-0.5-0.5-0.4-0.5-0.3-0.50.40.9-0.8-0.80.8-0.6
Reaction time mean0.30.41.3-0.2-0.20.20.20.00.2-0.00.1-0.1-1.11.11.0-1.00.9
Reaction time mean AUC0.10.20.60.10.1-0.1-0.1-0.2-0.1-0.3-0.20.1-0.80.70.7-0.70.5
Median of all reaction times0.10.10.40.10.1-0.1-0.1-0.2-0.1-0.3-0.10.2-0.60.60.5-0.50.4
Reaction time omissions1.42.14.0-1.1-1.11.11.10.91.10.91.1-1.1-2.02.02.0-2.01.9
Reaction time false alarm rate4.05.56.8-2.2-2.22.22.22.12.22.12.3-2.2-2.62.62.5-2.62.5
Reaction time premature initiation rate0.10.10.3-0.1-0.10.10.1-0.10.1-0.1-0.1-0.0-0.50.50.5-0.50.4
Reaction time premature initiations0.00.10.20.30.3-0.3-0.3-0.4-0.3-0.4-0.50.30.1-0.1-0.10.1-0.1
Std. dev. reaction times0.81.53.6-0.7-0.70.70.70.60.70.50.7-0.7-1.91.81.8-1.81.7
Reaction time trials completed0.20.40.70.50.5-0.5-0.5-0.4-0.5-0.3-0.50.40.9-0.8-0.80.8-0.6
Reaction time trials AUC0.10.20.50.30.3-0.3-0.3-0.2-0.3-0.1-0.30.20.7-0.7-0.60.6-0.4
Run reversals in cocaine runway, females0.00.00.10.10.1-0.1-0.1-0.2-0.1-0.2-0.00.1-0.40.30.3-0.30.2
Run reversals in cocaine runway, males3.23.23.8-1.7-1.71.71.71.71.71.71.6-1.7-1.91.91.9-1.91.9
Latency to leave start box in cocaine runway0.40.40.9-0.8-0.80.80.80.80.80.80.9-0.80.00.00.0-0.10.1
Latency to leave start box in cocaine runway, F0.60.71.2-1.0-1.01.01.01.11.01.11.1-1.00.10.00.0-0.00.1
Latency to leave start box in cocaine runway, M0.10.10.20.10.1-0.1-0.1-0.1-0.1-0.10.10.1-0.50.40.4-0.40.4
Std. dev. time between licks in bursts1.31.82.71.51.5-1.5-1.5-1.6-1.5-1.6-1.51.50.7-0.8-0.90.8-1.0
Total sessions with >9 infusions0.00.00.1-0.1-0.10.10.10.00.10.00.00.0-0.30.30.3-0.30.2
Short access day 1 total inactive lever presses1.11.52.0-1.4-1.41.41.41.41.41.41.4-1.4-0.70.80.8-0.80.9
Short access day 10 total inactive lever presses0.10.20.3-0.5-0.50.50.50.50.50.50.5-0.5-0.40.40.5-0.50.5
Short access day 1 total infusions0.00.00.0-0.0-0.00.00.00.00.00.0-0.00.00.1-0.1-0.10.1-0.1
Short access day 10 total infusions0.10.10.3-0.1-0.10.10.10.20.10.10.1-0.10.6-0.5-0.50.5-0.4
Short access total infusions0.00.00.10.20.2-0.2-0.2-0.2-0.2-0.2-0.30.20.1-0.1-0.10.2-0.1
Short access day 1 locomotion1.41.71.9-1.3-1.31.31.31.31.31.31.2-1.3-1.41.41.3-1.31.3
Short access day 10 total locomotion0.30.60.8-0.8-0.80.80.80.90.80.90.8-0.8-0.50.50.5-0.50.6
Short access total locomotion0.00.10.10.20.2-0.2-0.2-0.2-0.2-0.2-0.30.30.2-0.2-0.30.3-0.3
One hour access (0.3 mA shock)0.00.00.10.20.2-0.2-0.2-0.2-0.2-0.2-0.00.2-0.0-0.0-0.0-0.0-0.1
Compulsive drug intake1.01.21.41.11.1-1.1-1.1-1.1-1.1-1.1-1.11.11.1-1.1-1.21.1-1.2
One hour access (shock baseline)1.01.62.0-1.3-1.31.31.31.31.31.31.4-1.3-1.11.21.2-1.21.2
Social response proportion0.00.00.10.10.1-0.1-0.1-0.2-0.1-0.2-0.30.2-0.20.20.2-0.20.1
Social responses0.50.71.30.90.9-0.9-0.9-1.1-0.9-1.1-1.11.00.4-0.4-0.40.4-0.5
Social time0.20.20.6-0.4-0.40.40.40.30.40.30.3-0.4-0.50.50.6-0.60.8
Soleus weight2.36.88.9-2.8-2.82.82.83.02.93.02.9-2.8-1.92.02.0-2.02.1
Bone: stiffness0.00.00.1-0.1-0.10.10.10.00.00.00.0-0.0-0.30.20.2-0.20.1
Tibialis anterior weight1.44.78.7-2.5-2.52.52.52.82.63.02.6-2.5-0.60.80.8-0.81.1
Time to tail flick, vehicle, before self-admin1.11.22.4-1.2-1.21.21.21.31.21.31.6-1.4-0.40.40.5-0.50.5
Time to tail flick, vehicle, after self-admin0.10.20.3-0.5-0.50.50.50.60.50.60.4-0.50.2-0.2-0.20.2-0.1
Time to tail flick, test, before self-admin0.80.81.4-1.0-1.01.01.01.21.01.11.1-1.00.7-0.6-0.50.5-0.3
Time to tail flick, test, after self-admin0.40.40.8-0.8-0.80.80.80.90.80.90.6-0.70.00.10.1-0.00.2
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.0-0.00.00.00.00.00.0-0.30.10.2-0.2-0.20.2-0.1
Delta time to tail flick, test, before/after SA0.20.20.6-0.0-0.00.00.0-0.10.0-0.1-0.20.1-0.80.70.7-0.70.6
Tibia length0.10.30.3-0.6-0.60.60.60.60.60.60.5-0.6-0.40.40.4-0.40.5
Ambulatory time before self-admin0.00.00.0-0.2-0.20.20.20.10.20.1-0.10.00.1-0.1-0.10.2-0.0
Ambulatory time after self-admin0.30.40.6-0.8-0.80.80.80.80.80.80.4-0.6-0.30.30.3-0.30.4
Bone: tissue strength0.20.20.40.50.5-0.5-0.5-0.6-0.5-0.7-0.50.5-0.10.10.0-0.0-0.1
Total heroin consumption0.20.30.50.50.5-0.5-0.5-0.6-0.5-0.6-0.70.70.4-0.4-0.40.4-0.4
Bone: trabecular number0.60.91.21.11.1-1.1-1.1-1.1-1.1-1.1-1.01.10.7-0.7-0.80.8-0.9
Bone: trabecular spacing0.60.81.3-1.0-1.01.01.01.11.01.11.0-1.0-0.40.50.6-0.50.7
Bone: trabecular thickness0.20.20.40.50.5-0.5-0.5-0.6-0.5-0.6-0.50.50.0-0.1-0.10.1-0.3
Bone: trabecular tissue density0.61.01.31.01.0-1.0-1.0-0.8-0.9-0.7-0.80.81.1-1.1-1.11.1-1.1
Water consumed over 24 hours1.92.63.5-1.6-1.61.61.61.51.61.41.6-1.5-1.91.91.7-1.61.4
Number of responses in last shaping day2.72.93.5-1.8-1.81.81.81.81.81.81.9-1.8-1.51.51.5-1.51.5