Hub : Genes

Btbd6

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	Btbd6	0.24	0.15	1.9e-11	0.08	0.09	0.08	0.09	1.5e-09	1.1e-09	9.2e-09	8.8e-10
2	Liver	gene expression	Btbd6	0.16	0.15	5.6e-06	0.04	0.03	0.03	0.04	2.2e-05	2.1e-04	2.0e-04	4.8e-05
3	BLA	gene expression	Btbd6	0.06	0.05	3.9e-03	0.04	0.03	0.03	0.03	3.2e-03	7.8e-03	1.1e-02	6.5e-03
4	Brain	gene expression	Btbd6	0.02	0.02	6.7e-03	0.01	0.01	0.02	0.02	6.3e-02	3.1e-02	3.5e-03	9.7e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.0
Area under the delay curve	0.7	0.8	1.6	-1.3	1.1	0.5	-0.3
BMI with tail	1.4	4.5	6.6	-2.5	2.0	2.6	-1.1
BMI without tail	0.6	1.1	1.9	-1.4	1.1	1.0	-0.7
Body weight	1.7	7.2	9.3	2.6	-2.9	-2.1	3.1
Weight adjusted by age	0.2	0.2	0.4	0.4	-0.1	-0.7	0.6
Bone surface	0.4	0.8	1.5	-0.8	0.9	0.4	-1.2
Bone volume	0.3	0.6	1.3	-0.7	0.7	0.2	-1.1
Breakpoint value in progressive ratio session	0.1	0.1	0.3	0.2	-0.2	0.5	-0.1
Number of licking bursts	1.0	1.2	1.8	-1.2	1.3	0.6	-1.0
Context. condit. distance diff. score	2.8	3.4	4.0	2.0	-2.0	-2.0	1.3
Locomotion velocity, session 1	0.5	0.6	1.7	0.5	-0.3	-0.5	1.3
Locomotion distance, session 1	0.2	0.3	0.4	-0.3	0.5	0.6	0.6
Locomotion velocity, session 2	0.3	0.3	0.7	-0.6	0.9	0.3	0.4
Locomotion distance, session 2	0.6	0.8	1.2	-1.1	1.1	0.8	-0.4
Locomotion velocity, session 3	0.1	0.2	0.5	-0.1	0.7	0.1	0.4
Locomotion distance, session 3	0.1	0.1	0.4	-0.1	0.6	0.1	0.3
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	0.1	-0.0	-0.3	-0.0
Stereotopy head waving duration, day 3	0.0	0.1	0.2	0.1	-0.1	-0.5	-0.1
Locomotion velocity, session 7	0.1	0.1	0.1	0.3	-0.3	0.1	-0.1
Locomotion distance, session 7	0.7	0.9	1.1	-0.9	1.1	1.0	-0.8
Stereotopy head waving bouts, day 7	2.3	2.6	3.4	1.8	-1.6	-1.7	1.3
Stereotopy head waving duration, day 7	1.4	1.7	2.3	1.5	-1.3	-1.2	1.0
Locomotion velocity, session 8	1.9	2.2	3.0	1.6	-1.7	-1.3	1.3
Locomotion distance, session 8	0.3	0.5	0.5	0.7	-0.7	-0.7	0.7
Degree of sensitization distance	0.3	0.3	0.7	-0.5	0.2	0.5	-0.9
Degree of sensitization stereotypy	1.0	1.0	1.5	1.2	-1.1	-0.9	0.8
Conditioned locomotion	1.8	2.1	2.4	1.5	-1.4	-1.3	1.5
Cocaine response after cond. corrected	0.1	0.2	0.3	0.1	-0.1	0.6	0.5
Cocaine response after cond. not corrected	0.4	0.5	1.5	-0.5	0.4	1.2	0.3
Cocaine response before conditioning	2.1	2.6	3.5	-1.9	1.5	1.8	-1.3
Saline control response	0.1	0.1	0.2	0.3	0.1	-0.3	0.4
Bone: connectivity density	0.3	0.4	0.6	0.8	-0.7	-0.6	0.4
Bone: cortical apparent density	4.3	5.7	7.3	2.3	-2.3	-2.7	2.2
Bone: cortical area	0.2	0.2	0.4	0.4	-0.2	-0.6	-0.6
Bone: cortical porosity	0.1	0.1	0.2	0.3	-0.4	-0.5	-0.1
Bone: cortical porosity	0.1	0.1	0.3	0.4	-0.5	-0.2	-0.0
Bone: cortical thickness	0.5	0.8	1.3	1.2	-1.0	-0.8	0.3
Bone: cortical thickness	0.5	0.6	1.2	0.8	-0.5	-1.1	0.4
Bone: cortical tissue density	4.3	5.6	7.4	2.3	-2.3	-2.7	2.2
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.4	0.5	0.5	0.1
Condit. Reinf. active-inactive response ratio	1.3	1.4	2.3	-1.2	1.1	1.5	-0.8
Condit. Reinf. active responses	0.3	0.4	1.1	0.4	-0.3	-0.1	1.1
Condit. Reinf. inactive responses	2.6	3.1	4.8	1.7	-1.4	-1.7	2.2
Incentive salience index mean	0.2	0.2	0.8	0.2	-0.2	0.2	0.9
Condit. Reinf. lever presses	0.3	0.5	0.9	0.5	-0.8	-0.1	0.9
Condit. Reinf. active minus inactive responses	0.4	0.5	0.8	0.6	-0.5	-0.9	0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.2	-0.2	-0.5	0.1
Condit. Reinf. active responses	0.0	0.1	0.2	-0.1	0.0	-0.3	0.4
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.6	0.4	0.4	0.3
Condit. Reinf. lever presses	1.8	2.5	3.1	-1.8	1.7	1.4	-1.4
Condit. Reinf. lever reinforcers received	0.1	0.1	0.3	-0.1	0.0	-0.4	0.5
Conditioned reinforcement - actives	1.1	1.1	1.6	0.9	-1.0	-1.3	0.9
Conditioned reinforcement - inactives	0.8	1.0	2.1	0.7	-0.6	-1.0	1.4
Conditioned locomotion	0.0	0.0	0.0	-0.1	-0.1	0.2	0.1
Patch foraging indifference point 0 sec	5.7	9.2	11.2	3.3	-3.1	-2.9	2.8
Patch foraging indifference point AUC	6.8	7.8	9.5	3.1	-3.0	-1.9	3.0
Delay disc. indifference point, 0s delay	0.5	0.5	0.6	0.6	-0.7	-0.8	0.8
Delay disc. indifference point, 16s delay	1.0	1.0	1.7	-1.3	1.2	0.7	-0.5
Delay disc. indifference point, 2s delay	3.2	3.5	5.1	-2.3	2.3	1.0	-1.6
Delay disc. indifference point, 24s delay	0.8	0.8	1.6	-1.2	1.0	0.6	-0.2
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	-0.8	0.6	-0.3	0.1
Delay disc. indifference point, 8s delay	0.3	0.3	0.5	-0.7	0.7	0.3	0.2
Indifference point function ln k	0.3	0.5	1.3	0.5	-0.5	-1.1	0.1
Indifference point function log k	0.3	0.5	1.3	0.5	-0.5	-1.1	0.1
Patch foraging total patch changes 0 sec	7.0	11.2	13.6	3.7	-3.5	-3.1	3.1
Patch foraging total patch changes 12 sec	4.0	5.1	6.4	2.4	-2.0	-2.1	2.5
Patch foraging total patch changes 18 sec	2.7	3.5	4.3	2.1	-1.8	-1.5	2.1
Patch foraging total patch changes 24 sec	1.3	1.5	1.9	1.3	-1.3	-0.9	1.4
Patch foraging total patch changes 6 sec	6.2	9.2	11.3	3.4	-3.1	-2.2	3.3
Patch foraging time to switch 0 sec	11.3	17.4	19.0	-4.4	4.3	4.1	-3.9
Patch foraging water rate 0 sec	15.6	25.1	27.9	5.3	-5.0	-5.3	4.4
Patch foraging water rate 12 sec	6.5	9.9	13.7	2.6	-2.7	-3.7	3.4
Patch foraging water rate 18 sec	3.6	4.8	7.2	1.9	-2.0	-2.7	2.1
Patch foraging water rate 24 sec	2.9	4.0	5.1	1.8	-1.7	-2.3	2.1
Patch foraging water rate 6 sec	4.0	5.8	6.9	2.4	-2.4	-2.6	2.2
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	0.7	-0.5	-0.7	0.5
Distance traveled before self-admin	0.7	0.7	1.1	-1.0	1.1	0.8	-0.4
Distance traveled after self-admin	0.1	0.2	0.5	0.2	-0.1	-0.7	0.1
Extensor digitorum longus weight	8.7	34.2	40.7	6.4	-6.1	-6.0	4.8
Bone: elastic displacement	0.1	0.1	0.2	-0.2	0.1	-0.5	-0.4
Bone: elastic work	0.8	1.0	1.6	-1.2	1.0	0.4	-1.3
Bone: endosteal estimation	1.7	3.7	5.6	-2.0	2.1	1.0	-2.4
Bone: endosteal perimeter	0.4	0.9	1.8	-0.8	1.0	0.4	-1.3
Epididymis fat weight	1.9	4.5	7.5	-2.1	1.8	2.7	-1.7
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.3	-0.5	-0.3	0.2
Delta time in open arm before/after self-admin	1.0	0.9	1.2	1.1	-0.9	-1.0	0.9
Diff in mean of infusions in LGA sessions	0.5	0.6	1.1	1.1	-0.9	-0.1	0.5
Delay discount exponential model param	0.6	0.6	1.3	1.1	-1.0	-0.3	0.2
Extinction: sum of active levers before priming	0.0	0.0	0.0	0.0	-0.0	0.1	-0.2
Active lever presses in extinction session 6	1.3	1.3	1.4	1.1	-1.1	-1.2	1.1
Bone: final force	0.6	1.0	3.1	-0.6	0.8	0.0	-1.8
Bone: final moment	0.5	0.8	2.8	-0.4	0.5	-0.1	-1.7
Food consumed during 24 hour testing period	1.0	1.2	1.4	1.1	-0.9	-1.1	1.2
Glucose	0.1	0.1	0.3	0.1	0.2	-0.5	-0.4
Heart weight	0.4	0.5	1.3	-0.5	0.6	0.2	-1.1
Delay discount hyperbolic model param	0.8	0.9	1.7	1.3	-1.2	-0.4	0.3
Intermittent access intake day 1-15 change	1.2	1.2	1.4	-1.2	1.1	1.2	-0.8
Intermittent access intake escalation	1.3	1.2	1.4	-1.2	1.1	1.2	-0.9
Intermittent access intake escalation 2	0.2	0.2	0.4	-0.3	0.3	0.5	-0.6
Intermitt. access day 1 inactive lever presses	3.3	3.5	5.4	1.8	-1.5	-1.8	2.3
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.2	0.7	-0.5	-1.0	1.1
Intermitt. access escalation Index	0.1	0.1	0.2	0.0	0.4	-0.4	0.1
Intermittent access day 1 total infusions	0.1	0.1	0.2	0.3	-0.4	0.1	0.4
Intermittent access day 15 total infusions	0.8	0.9	1.4	-1.0	0.9	1.2	-0.6
Intermittent access terminal intake (last 3 days)	1.0	1.1	1.6	-1.1	1.1	1.3	-0.6
Intermittent access total infusions	0.1	0.1	0.2	-0.2	0.2	0.5	0.0
Intermittent access day 1 locomotion	0.1	0.1	0.2	-0.1	-0.1	0.5	-0.2
Intermittent access day 15 total locomotion	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.1
Intermittent access total locomotion	0.1	0.1	0.1	0.2	-0.3	0.1	0.3
Intermittent access standard deviation	0.6	0.6	2.0	-0.6	0.4	1.4	0.1
Left kidney weight	2.4	6.8	8.9	3.0	-3.0	-2.5	1.8
Right kidney weight	1.2	3.3	4.1	2.0	-2.0	-1.9	1.2
Cocaine induced anxiety	0.3	0.4	0.9	0.6	-0.4	-1.0	0.2
Post-drug Anxiety	0.3	0.3	0.5	0.6	-0.4	-0.7	0.4
Baseline Anxiety	0.6	0.7	1.2	-0.8	0.7	1.1	-0.5
Tail length	5.1	15.5	17.0	4.1	-4.0	-4.1	3.6
Length with tail	9.3	33.9	37.7	6.1	-6.1	-5.6	5.4
Length without tail	5.6	12.2	14.4	3.8	-3.8	-3.0	3.3
Times rat made contact with spout	0.4	0.5	1.4	0.6	-0.3	-0.5	1.2
Lifetime Intake	0.1	0.1	0.1	-0.4	0.3	0.3	-0.1
Liver weight, left	2.4	3.8	4.7	2.1	-2.2	-1.8	1.7
Liver weight, right	1.0	1.6	3.7	1.1	-1.0	-0.6	1.9
Locomotor activity	0.2	0.2	0.4	0.4	-0.4	-0.5	0.6
Locomotor testing distance	0.1	0.2	0.3	0.3	-0.3	-0.5	0.5
Locomotor testing rearing	1.7	2.6	3.7	-1.8	1.9	1.8	-0.7
Locomotion in novel chamber	3.2	3.9	5.9	1.8	-1.7	-2.4	1.9
Locomotion in novel chamber post-restriction	0.2	0.3	0.4	-0.5	0.6	0.2	-0.6
Fecal boli incidents, locomotor time 1	0.4	0.4	1.1	-0.4	0.2	1.0	-0.5
Change in fecal boli incidents, locomotor task	1.9	1.8	2.4	1.2	-1.2	-1.5	1.4
Time >=10cm from walls, locomotor time 1	2.6	2.6	4.5	1.8	-2.1	-0.3	1.7
Bouts of movement, locomotor time 1	1.0	1.1	1.5	-1.1	1.1	1.2	-0.8
Total resting periods, locomotor time 1	1.2	1.3	1.5	-1.2	1.2	1.2	-0.9
Rest time, locomotor task time 1	0.3	0.3	0.8	-0.9	0.7	0.1	-0.0
Distance moved, locomotor task time 1	1.0	1.0	1.6	-1.0	0.9	0.9	-1.3
Vertical activity count, locomotor time 1	0.1	0.1	0.2	-0.0	0.1	0.3	-0.5
Time >=10cm from walls, locomotor time 2	2.2	2.3	3.3	1.8	-1.8	-0.9	1.5
Bouts of movement, locomotor time 2	0.4	0.5	1.3	-0.3	0.6	-1.2	-0.2
Total resting periods, locomotor time 2	0.4	0.4	0.9	-0.5	0.7	-1.0	-0.2
Rest time, locomotor task time 2	0.1	0.1	0.4	-0.4	0.0	-0.2	0.6
Distance moved, locomotor task time 2	0.6	0.6	0.9	-0.6	0.8	0.9	-0.9
Vertical activity count, locomotor time 2	0.0	0.0	0.2	0.4	-0.1	0.0	-0.1
Light reinforcement 1	0.0	0.0	0.0	0.0	-0.1	-0.0	-0.1
Light reinforcement 2	1.2	1.7	2.9	-1.3	0.8	1.7	-1.2
Bone: marrow area	1.7	3.7	5.6	-2.0	2.0	1.0	-2.4
Bone: maximum diameter	0.3	0.5	1.1	-0.6	0.8	0.4	-1.0
Bone: maximum force	0.3	0.5	1.9	-0.2	0.3	-0.2	-1.4
Bone: maximum moment	0.2	0.4	1.6	-0.0	0.1	-0.3	-1.3
Mean time between licks in bursts	0.5	0.6	0.9	-0.8	0.7	0.9	-0.6
Mean num. licks in bursts	1.5	1.8	2.4	1.5	-1.4	-0.9	1.6
Cd content in liver	0.9	1.0	1.6	0.8	-0.7	-1.3	1.1
Co content in liver	1.3	1.6	2.1	1.2	-0.9	-1.4	1.3
Cu content in liver	2.3	2.8	3.1	-1.7	1.7	1.8	-1.4
Fe content in liver	1.4	1.7	2.9	-1.2	1.1	1.2	-1.7
K content in liver	1.4	1.4	2.1	1.0	-1.4	-0.6	1.5
Mg content in liver	0.3	0.3	0.5	0.3	-0.7	-0.4	0.6
Mn content in liver	0.2	0.2	0.4	0.3	-0.5	-0.6	-0.4
Na content in liver	0.1	0.1	0.2	0.1	-0.3	0.5	0.1
Rb content in liver	0.4	0.5	1.0	0.5	-0.3	-1.0	0.8
Se content in liver	0.0	0.1	0.2	-0.0	-0.0	0.2	0.4
Sr content in liver	0.2	0.1	0.3	-0.2	0.6	-0.3	0.3
Zn content in liver	0.1	0.1	0.1	-0.2	0.3	-0.3	0.3
Bone: minimum diameter	0.3	0.6	1.3	0.7	-0.5	-1.1	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.0	0.3	0.1	-0.4
Time in novel zone, hab. session 1	0.6	0.6	1.0	-1.0	0.9	0.6	-0.3
Total zone transitions, hab. session 1	0.7	1.0	1.6	-1.1	0.9	0.7	-1.3
Total locomotion distance, hab. session 1	0.1	0.2	0.4	-0.2	0.1	-0.4	-0.6
Locomotion velocity, hab. session 1	0.3	0.4	0.8	0.5	-0.6	-0.9	0.0
Time in familiar zone, hab. session 2	0.4	0.5	0.7	0.7	-0.8	-0.2	0.8
Time in novel zone, hab. session 2	0.9	0.9	1.4	-1.1	1.2	0.6	-0.9
Total zone transitions, hab. session 2	0.1	0.2	0.3	-0.4	0.5	0.5	0.3
Total locomotion distance, hab. session 2	0.3	0.3	0.6	0.5	-0.2	-0.7	0.7
Locomotion velocity, hab. session 2	0.4	0.5	0.9	0.6	-0.4	-0.9	0.7
Novel to familiar place preference ratio	0.6	0.6	1.0	-0.8	1.0	0.7	-0.6
Novelty place preference	0.7	0.8	1.3	-0.9	1.1	0.7	-0.7
Time in novel zone, NPP test	0.2	0.2	0.5	-0.5	0.7	0.4	-0.3
Total zone transitions, NPP test	1.0	1.4	3.6	0.8	-0.8	-0.9	1.9
Total locomotion distance, NPP test	0.6	0.8	1.4	0.7	-0.7	-0.8	1.2
Locomotion velocity, NPP test	0.3	0.4	0.7	0.5	-0.5	-0.8	0.8
Intraocular pressure	0.2	0.3	0.5	-0.7	0.7	-0.0	-0.1
Delta distance traveled before/after self-admin	0.3	0.4	0.9	0.6	-0.4	-0.9	-0.0
Delta ambulatory time before/after self-admin	1.0	1.1	2.3	0.9	-1.0	-1.5	0.4
Parametrial fat weight	0.1	0.1	0.2	-0.5	0.5	0.3	0.1
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.1	0.2	-0.5	-0.6
Pavlov. Cond. magazine entry latency	0.2	0.3	0.9	-0.1	-0.2	0.5	-0.9
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.1	-0.3	0.2	0.1
Pavlov. Cond. index score	0.1	0.1	0.4	-0.1	-0.2	0.6	-0.2
Pavlov. Cond. latency score	0.1	0.1	0.3	-0.1	-0.2	0.5	-0.1
Pavlov. Cond. lever contacts	0.3	0.3	0.8	-0.5	0.3	0.9	-0.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.0	0.4	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	8.6	10.4	11.7	3.4	-3.0	-3.2	3.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.3	-0.1	-0.3	0.6	-0.3
Pavlov. Cond. response bias	0.1	0.1	0.2	0.1	-0.5	0.5	-0.0
Pavlov. Cond. lever latency	2.8	3.7	4.7	2.2	-2.1	-1.8	1.6
Pavlov. Cond. magazine entry latency	3.0	3.5	4.9	-2.0	2.2	2.0	-0.9
Pavlov. Cond. change in total contacts	6.0	8.3	9.9	-3.0	3.1	2.7	-2.6
Pavlov. Cond. index score	4.1	5.3	6.8	-2.5	2.6	2.3	-1.6
Pavlov. Cond. latency score	3.6	4.5	5.6	-2.3	2.4	2.3	-1.3
Pavlov. Cond. lever contacts	2.9	3.9	4.9	-2.2	2.2	2.0	-1.4
Pavlov. Cond. magazine entry number	2.7	3.3	5.4	1.9	-2.3	-1.8	0.9
Pavlov. Cond. intertrial magazine entries	4.7	6.1	7.0	2.4	-2.6	-2.6	2.2
Pavlov. Cond. lever-magazine prob. diff.	4.8	6.1	7.8	-2.7	2.8	2.5	-1.7
Pavlov. Cond. response bias	3.0	4.1	5.2	-2.3	2.3	2.0	-1.4
Time in closed arm before self-admin	7.4	8.3	10.1	-3.2	3.1	2.9	-2.3
Time in closed arm after self-admin	5.3	5.4	8.1	-2.8	2.5	1.8	-2.1
Time in open arm before self-admin	6.1	6.7	7.3	2.6	-2.5	-2.7	2.5
Time in open arm after self-admin	9.2	10.2	13.2	3.6	-3.4	-2.8	2.8
Bone: periosteal estimation	0.7	1.5	3.5	-1.0	1.2	0.2	-1.9
Bone: periosteal perimeter	0.1	0.2	0.7	-0.3	0.4	0.1	-0.9
Bone: post-yield work	1.4	1.9	2.7	1.6	-1.4	-1.6	0.5
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.2	-0.1	0.2
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	-0.3	0.4	0.1	0.2
Progressive ratio test 1 inactive lever presses	2.5	2.7	4.2	1.4	-1.2	-2.0	1.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.2	-0.1	0.1	0.1
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.2
Progressive ratio test 2 inactive lever presses	0.2	0.2	0.4	-0.0	-0.1	-0.7	0.6
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.4	-0.0	0.2	-0.1
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	-0.4	-0.0	0.1	-0.1
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	-0.4	0.5	0.7	-0.5
Progressive ratio	1.2	1.4	2.3	-1.5	1.2	0.1	-1.3
Food seeking constrained by brief footshock	0.2	0.2	0.6	0.0	0.2	-0.8	0.3
Seeking ratio, punishment vs. effort	0.8	1.0	1.5	1.2	-0.8	-0.5	1.2
Retroperitoneal fat weight	0.0	0.1	0.2	-0.2	0.3	0.4	0.3
Reaction time number correct	3.7	5.3	6.3	2.5	-2.4	-2.4	1.9
Reaction time mean minus median	0.1	0.1	0.2	-0.2	0.0	0.0	0.5
Reaction time mean minus median AUC	0.0	0.1	0.2	-0.2	-0.0	-0.2	0.4
Reaction time num false alarms	1.9	2.6	3.0	1.6	-1.7	-1.6	1.5
Reaction time num false alarms AUC	2.0	2.8	3.4	1.6	-1.9	-1.8	1.4
Reaction time trials correct on left	3.7	5.3	6.3	2.5	-2.4	-2.4	1.9
Reaction time trials on left	3.8	5.4	6.3	2.5	-2.4	-2.4	1.9
Reaction time mean	1.3	1.8	3.1	-1.8	1.5	1.1	-1.0
Reaction time mean AUC	0.7	1.0	1.9	-1.4	1.1	0.7	-0.6
Median of all reaction times	1.2	1.7	2.8	-1.7	1.4	0.9	-1.1
Reaction time omissions	1.3	1.8	2.9	1.0	-1.1	-1.7	1.4
Reaction time false alarm rate	0.2	0.2	0.3	0.3	-0.6	-0.6	0.5
Reaction time premature initiation rate	0.1	0.2	0.3	0.5	-0.4	-0.5	0.1
Reaction time premature initiations	1.7	2.5	3.4	1.8	-1.7	-1.7	1.0
Std. dev. reaction times	0.7	1.0	2.0	-1.4	1.2	0.7	-0.6
Reaction time trials completed	3.8	5.4	6.3	2.5	-2.4	-2.4	1.9
Reaction time trials AUC	3.9	5.6	6.5	2.6	-2.5	-2.4	1.9
Run reversals in cocaine runway, females	2.8	2.7	3.4	-1.8	1.5	1.4	-1.8
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.2	0.3	-0.0	-0.2
Latency to leave start box in cocaine runway	0.7	0.8	1.5	-1.0	1.2	0.4	-0.7
Latency to leave start box in cocaine runway, F	0.3	0.3	0.4	-0.5	0.5	0.6	-0.6
Latency to leave start box in cocaine runway, M	0.6	0.6	1.6	-0.8	1.3	0.2	-0.4
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.3	-0.0	-0.3	0.1
Total sessions with >9 infusions	0.0	0.0	0.1	-0.2	0.4	0.1	0.1
Short access day 1 total inactive lever presses	0.1	0.1	0.2	-0.3	0.4	-0.2	0.4
Short access day 10 total inactive lever presses	0.5	0.6	1.2	0.3	-0.2	-1.0	1.1
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	0.2	-0.4	0.2
Short access day 10 total infusions	0.2	0.2	0.3	-0.5	0.4	0.4	-0.2
Short access total infusions	0.6	0.7	1.0	-1.0	1.0	0.5	-0.7
Short access day 1 locomotion	0.3	0.3	0.5	-0.7	0.7	0.5	-0.2
Short access day 10 total locomotion	0.1	0.1	0.2	0.0	0.1	0.4	0.4
Short access total locomotion	0.1	0.1	0.1	-0.2	0.3	0.0	0.4
One hour access (0.3 mA shock)	0.7	0.8	1.3	0.9	-0.9	-0.5	1.1
Compulsive drug intake	0.5	0.5	0.7	0.8	-0.8	-0.3	0.7
One hour access (shock baseline)	0.1	0.1	0.2	-0.3	0.4	0.1	0.1
Social response proportion	0.4	0.4	0.8	-0.9	0.4	0.2	-0.8
Social responses	0.4	0.6	1.0	-1.0	0.9	0.3	-0.7
Social time	0.2	0.3	1.2	-0.3	0.1	-1.1	-0.2
Soleus weight	2.0	5.8	7.6	2.8	-2.6	-1.8	2.4
Bone: stiffness	0.6	1.0	1.6	1.2	-0.8	-1.3	0.3
Tibialis anterior weight	0.9	2.9	3.8	2.0	-1.6	-1.5	1.7
Time to tail flick, vehicle, before self-admin	3.2	3.3	6.1	1.7	-1.6	-1.3	2.5
Time to tail flick, vehicle, after self-admin	0.9	0.9	1.3	1.1	-1.0	-0.5	1.1
Time to tail flick, test, before self-admin	0.1	0.1	0.4	-0.4	0.6	-0.2	0.0
Time to tail flick, test, after self-admin	4.6	4.8	6.5	2.4	-2.5	-1.5	2.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.2	0.5	-0.4	-0.2	-0.5
Delta time to tail flick, test, before/after SA	5.1	4.6	6.9	2.3	-2.6	-1.5	1.9
Tibia length	0.1	0.2	0.4	0.3	-0.7	-0.3	0.1
Ambulatory time before self-admin	1.0	1.0	1.5	-1.0	1.2	1.1	-0.5
Ambulatory time after self-admin	0.2	0.2	0.4	-0.4	0.7	0.0	-0.5
Bone: tissue strength	0.7	0.7	1.8	-0.7	0.5	0.4	-1.3
Total heroin consumption	2.3	2.6	3.7	1.9	-1.9	-1.2	1.4
Bone: trabecular number	0.2	0.4	0.5	0.7	-0.6	-0.7	0.4
Bone: trabecular spacing	0.0	0.0	0.1	-0.3	0.0	0.2	-0.3
Bone: trabecular thickness	0.1	0.1	0.2	0.2	-0.4	-0.2	0.4
Bone: trabecular tissue density	0.0	0.0	0.0	0.0	-0.2	0.0	-0.0
Water consumed over 24 hours	1.3	1.5	2.8	1.1	-0.9	-1.7	1.1
Number of responses in last shaping day	0.6	0.6	0.7	-0.8	0.8	0.7	-0.8