Hub : Genes

Brpf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Brpf3 0.06 0.04 2.6e-07 0.04 0.05 0.06 0.06 2.6e-04 1.1e-05 1.8e-06 4.5e-06
2 RMTg alternative TSS XM_006256131.4 0.24 0.19 2.4e-03 0.05 0.07 0.09 0.07 1.5e-02 6.3e-03 2.2e-03 5.6e-03
3 RMTg alternative TSS XM_006256131.4 0.25 0.19 2.1e-03 0.03 0.08 0.11 0.07 5.2e-02 3.5e-03 8.3e-04 4.7e-03
4 BLA mRNA stability Brpf3 0.06 0.04 9.8e-04 0.06 0.05 0.05 0.05 4.5e-04 1.2e-03 8.5e-04 1.0e-03
5 NAcc gene expression Brpf3 0.03 0.02 5.4e-04 0.02 0.02 0.01 0.02 1.7e-03 2.5e-03 5.1e-02 5.0e-03
6 IL alternative TSS NM_001107615.1 0.16 0.11 1.2e-03 0.12 0.12 0.11 0.12 6.6e-04 1.0e-03 1.1e-03 7.1e-04
7 LHb mRNA stability Brpf3 0.14 0.11 6.2e-03 0.06 0.06 0.05 0.06 1.9e-02 1.2e-02 2.4e-02 2.0e-02
8 Brain alternative TSS XM_006256129.3 0.02 0.02 5.3e-03 0.01 0.01 0 0 6.9e-02 1.4e-02 1.1e-01 1.2e-01
9 PL mRNA stability Brpf3 0.04 0.03 1.7e-05 0.04 0.04 0.04 0.04 2.2e-05 1.8e-05 2.0e-05 1.5e-05
10 NAcc alternative TSS NM_001107615.1 0.03 0.02 1.3e-03 0.02 0.02 0.02 0.02 2.1e-03 8.4e-04 3.2e-03 3.8e-03
11 IL alternative TSS NM_001107615.1 0.2 0.13 2.2e-04 0.15 0.14 0.14 0.14 2.0e-04 2.5e-04 3.2e-04 3.4e-04
12 Eye intron excision ratio chr20_6872359_6873274 0.94 0.07 6.9e-03 -0.01 0.1 0.19 0.12 4.4e-01 1.2e-02 6.8e-04 7.6e-03
13 Brain gene expression Brpf3 0.18 0.11 8.2e-03 0 0.01 0.01 -0 2.5e-01 1.7e-02 5.5e-02 4.9e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.30.61.1-0.50.40.4-0.80.7-1.00.8-0.90.80.8-0.70.5-0.9
Area under the delay curve0.60.71.40.0-1.1-1.20.7-0.41.1-1.10.9-0.7-1.00.9-0.4-0.3
BMI with tail1.55.06.62.5-2.2-2.21.9-1.82.6-2.52.4-2.4-2.32.4-2.11.4
BMI without tail1.32.66.21.5-1.4-1.41.5-1.21.7-1.51.6-1.6-1.51.5-2.51.8
Body weight5.523.228.53.5-5.3-5.35.3-4.75.2-5.35.1-4.9-5.35.3-4.12.2
Weight adjusted by age1.01.12.20.5-1.4-1.50.8-1.40.9-1.20.9-1.0-1.21.10.0-0.7
Bone surface0.00.10.2-0.2-0.5-0.50.00.0-0.2-0.0-0.0-0.0-0.10.00.0-0.3
Bone volume0.10.10.4-0.0-0.6-0.60.10.0-0.0-0.20.1-0.2-0.20.2-0.4-0.2
Breakpoint value in progressive ratio session0.50.52.80.40.70.8-0.6-0.2-0.50.6-0.50.40.6-0.51.7-0.8
Number of licking bursts0.70.91.5-1.01.21.2-1.01.1-0.81.0-0.80.80.9-0.80.40.8
Context. condit. distance diff. score0.60.82.8-1.70.70.7-0.90.9-0.40.7-0.70.90.7-0.71.1-0.3
Locomotion velocity, session 10.80.82.7-1.60.40.4-1.21.5-0.80.7-0.91.00.7-1.0-0.0-0.3
Locomotion distance, session 13.03.85.5-2.01.91.9-2.22.3-2.22.1-2.22.22.1-2.10.7-0.7
Locomotion velocity, session 20.50.61.4-0.90.70.8-1.20.9-0.50.6-0.50.70.6-0.51.00.1
Locomotion distance, session 20.71.01.4-1.10.90.8-1.11.0-1.21.0-1.21.21.0-1.10.6-0.9
Locomotion velocity, session 31.11.36.4-0.1-0.8-0.70.40.40.7-0.70.8-0.8-0.70.9-2.52.3
Locomotion distance, session 30.70.81.9-1.10.60.7-1.01.4-0.50.5-0.50.60.6-0.6-1.31.3
Stereotopy head waving bouts, day 31.51.82.70.2-1.3-1.31.7-1.31.6-1.51.5-1.3-1.51.6-0.81.0
Stereotopy head waving duration, day 30.10.20.4-0.3-0.6-0.60.4-0.30.4-0.40.3-0.2-0.40.40.2-0.4
Locomotion velocity, session 70.20.20.8-0.4-0.7-0.7-0.00.4-0.1-0.2-0.20.2-0.1-0.0-0.9-0.6
Locomotion distance, session 70.60.81.7-1.30.30.2-0.91.1-0.90.7-1.11.10.8-1.00.0-1.3
Stereotopy head waving bouts, day 70.80.94.00.0-0.5-0.50.40.00.7-0.70.8-0.7-0.70.7-1.92.0
Stereotopy head waving duration, day 71.41.64.60.6-1.1-1.10.9-0.51.2-1.21.3-1.3-1.21.2-2.02.2
Locomotion velocity, session 80.20.21.9-1.4-0.1-0.1-0.20.30.00.0-0.10.40.0-0.10.8-0.4
Locomotion distance, session 81.01.43.9-2.01.11.0-1.11.2-1.11.2-1.21.41.2-1.21.0-0.5
Degree of sensitization distance0.80.86.00.3-0.5-0.60.4-0.9-0.0-0.1-0.10.1-0.10.01.8-2.4
Degree of sensitization stereotypy0.40.53.3-0.30.10.2-0.40.70.00.00.1-0.2-0.00.0-1.41.8
Conditioned locomotion2.42.84.11.7-1.6-1.61.9-2.01.9-1.71.9-1.9-1.81.9-0.30.8
Cocaine response after cond. corrected0.40.50.90.9-0.3-0.30.9-0.90.8-0.70.8-0.7-0.70.7-0.40.4
Cocaine response after cond. not corrected0.40.40.90.6-0.2-0.20.9-1.00.8-0.70.8-0.7-0.70.7-0.30.5
Cocaine response before conditioning0.00.10.5-0.7-0.1-0.10.1-0.10.2-0.10.10.1-0.10.10.3-0.0
Saline control response1.01.36.02.5-0.7-0.71.1-1.61.1-1.01.0-1.1-0.91.1-0.3-0.4
Bone: connectivity density0.40.61.8-0.60.0-0.0-0.60.5-1.00.7-0.80.70.6-0.61.0-1.3
Bone: cortical apparent density0.10.10.60.80.10.10.8-0.7-0.0-0.00.1-0.2-0.10.2-0.30.1
Bone: cortical area0.30.42.40.2-0.8-0.80.40.00.7-0.70.5-0.4-0.60.4-1.50.3
Bone: cortical porosity0.20.21.0-0.9-0.4-0.5-0.10.60.0-0.1-0.10.2-0.10.0-1.00.1
Bone: cortical porosity0.20.20.9-0.9-0.5-0.6-0.00.50.0-0.1-0.20.2-0.1-0.0-0.6-0.5
Bone: cortical thickness0.30.43.70.20.30.3-0.40.9-0.20.2-0.50.40.3-0.5-1.90.3
Bone: cortical thickness0.10.11.21.10.10.1-0.0-0.20.3-0.10.1-0.3-0.10.1-0.60.1
Bone: cortical tissue density0.10.20.70.80.00.00.8-0.80.0-0.10.2-0.3-0.20.3-0.20.2
Condit. Reinf. active minus inactive responses1.01.13.2-0.60.40.3-1.40.9-1.10.8-1.00.90.8-0.81.8-1.8
Condit. Reinf. active-inactive response ratio0.20.21.10.70.20.2-0.5-0.1-0.40.2-0.20.20.2-0.11.1-0.9
Condit. Reinf. active responses0.30.41.8-0.0-0.0-0.1-0.80.3-0.50.2-0.50.30.2-0.21.3-1.3
Condit. Reinf. inactive responses0.10.10.6-0.10.10.0-0.30.1-0.40.3-0.40.20.2-0.10.6-0.7
Incentive salience index mean0.50.61.5-0.90.10.0-1.20.8-0.70.4-0.70.60.4-0.41.2-1.0
Condit. Reinf. lever presses0.10.20.8-0.9-0.2-0.2-0.80.7-0.30.1-0.30.30.1-0.20.4-0.3
Condit. Reinf. active minus inactive responses0.60.81.9-0.70.80.8-0.70.5-1.10.9-0.90.90.8-0.71.4-1.1
Condit. Reinf. active-inactive response ratio0.30.31.2-0.40.50.5-0.20.1-0.80.5-0.50.50.5-0.31.1-0.7
Condit. Reinf. active responses0.60.81.3-0.90.70.7-0.90.8-1.00.9-0.91.00.9-0.91.1-1.0
Condit. Reinf. inactive responses0.00.00.1-0.1-0.3-0.3-0.10.00.3-0.20.2-0.1-0.20.2-0.3-0.0
Condit. Reinf. lever presses3.54.75.7-1.72.32.2-2.21.8-2.12.2-2.32.42.3-2.42.3-2.1
Condit. Reinf. lever reinforcers received1.31.82.2-1.31.11.1-1.51.3-1.41.3-1.41.51.3-1.41.4-1.3
Conditioned reinforcement - actives0.80.81.9-0.4-1.3-1.40.8-0.30.8-1.00.6-0.6-0.90.8-1.40.2
Conditioned reinforcement - inactives0.20.31.2-0.20.60.6-0.30.5-0.20.4-0.30.40.4-0.3-1.10.7
Conditioned locomotion0.80.92.5-0.1-1.5-1.60.8-0.70.9-1.20.7-0.7-1.10.8-0.4-0.9
Patch foraging indifference point 0 sec0.40.71.91.2-0.4-0.40.9-0.80.7-0.70.7-0.8-0.70.8-1.40.8
Patch foraging indifference point AUC0.10.10.3-0.60.40.4-0.30.5-0.10.2-0.10.30.2-0.1-0.00.5
Delay disc. indifference point, 0s delay0.10.10.2-0.2-0.5-0.4-0.00.00.2-0.30.2-0.0-0.2-0.1-0.4-0.4
Delay disc. indifference point, 16s delay0.20.20.4-0.6-0.5-0.70.5-0.40.5-0.60.4-0.3-0.50.5-0.50.0
Delay disc. indifference point, 2s delay0.40.42.4-0.7-0.0-0.1-0.40.3-0.20.2-0.40.50.2-0.51.2-1.5
Delay disc. indifference point, 24s delay2.12.13.80.5-1.9-2.01.5-1.11.6-1.81.5-1.3-1.71.6-1.0-0.1
Delay disc. indifference point, 4s delay0.80.81.40.8-0.9-1.00.7-0.71.2-1.11.1-1.0-1.11.0-0.30.1
Delay disc. indifference point, 8s delay1.41.42.80.6-1.6-1.70.9-0.71.6-1.61.3-1.0-1.51.3-0.5-0.3
Indifference point function ln k0.20.30.9-1.00.20.2-0.60.8-0.50.3-0.40.40.3-0.5-0.30.3
Indifference point function log k0.20.30.9-1.00.20.2-0.60.8-0.50.3-0.40.40.3-0.5-0.30.3
Patch foraging total patch changes 0 sec0.40.72.41.2-0.3-0.40.8-0.70.7-0.60.7-0.7-0.60.8-1.60.8
Patch foraging total patch changes 12 sec0.30.31.30.40.80.8-0.40.40.10.2-0.00.10.2-0.1-1.11.1
Patch foraging total patch changes 18 sec0.91.23.31.8-0.3-0.31.0-1.01.2-0.81.0-0.9-0.81.0-1.81.2
Patch foraging total patch changes 24 sec0.30.41.30.51.11.1-0.40.4-0.60.7-0.60.60.7-0.5-0.1-0.1
Patch foraging total patch changes 6 sec0.20.31.61.30.20.20.5-0.40.2-0.20.3-0.4-0.10.3-1.00.7
Patch foraging time to switch 0 sec1.11.64.52.1-1.3-1.31.1-1.51.3-1.21.3-1.5-1.21.1-0.3-0.1
Patch foraging water rate 0 sec0.20.30.6-0.70.70.7-0.10.5-0.60.5-0.60.80.5-0.3-0.60.1
Patch foraging water rate 12 sec0.30.41.5-0.40.60.6-0.30.7-0.60.5-0.40.50.5-0.2-1.20.9
Patch foraging water rate 18 sec0.40.51.0-0.20.90.8-0.10.0-0.90.7-0.80.80.7-0.61.0-1.0
Patch foraging water rate 24 sec0.50.71.9-0.21.41.4-0.50.7-0.70.8-0.60.80.9-0.6-0.70.9
Patch foraging water rate 6 sec0.20.40.9-0.51.01.0-0.20.6-0.40.5-0.40.70.5-0.4-0.60.6
Seeking ratio, delayed vs. immediate footshock0.20.21.20.50.50.50.5-0.10.20.10.2-0.20.10.1-0.31.1
Distance traveled before self-admin0.90.93.41.0-0.10.00.9-1.11.0-0.71.1-1.0-0.71.0-0.61.8
Distance traveled after self-admin0.30.41.11.00.50.50.5-1.00.3-0.00.5-0.5-0.10.60.41.0
Extensor digitorum longus weight0.20.92.0-1.11.21.1-1.00.7-0.80.9-0.80.90.9-0.71.4-0.6
Bone: elastic displacement0.20.21.1-0.6-0.3-0.4-0.10.6-0.20.0-0.30.20.1-0.0-1.1-0.1
Bone: elastic work0.10.20.70.1-0.6-0.70.10.10.2-0.3-0.0-0.0-0.20.1-0.8-0.6
Bone: endosteal estimation2.75.98.81.7-3.0-2.92.4-2.82.7-2.72.7-2.5-2.72.6-0.20.2
Bone: endosteal perimeter1.32.74.01.4-1.6-1.51.9-2.01.8-1.82.0-1.8-1.81.8-0.30.9
Epididymis fat weight1.94.511.93.4-1.8-1.82.0-1.81.9-1.91.8-2.1-1.91.9-3.10.9
Delta time in closed arm before/after self-admin1.61.52.91.2-1.1-1.11.3-1.11.3-1.21.2-1.2-1.21.3-1.71.0
Delta time in open arm before/after self-admin0.80.81.3-0.60.70.7-1.00.6-0.90.8-0.90.80.8-1.01.1-1.1
Diff in mean of infusions in LGA sessions1.01.13.7-0.31.11.1-0.80.4-1.11.1-1.01.01.0-0.81.9-1.2
Delay discount exponential model param0.50.61.20.11.01.1-0.60.3-1.01.0-0.80.60.9-0.80.30.3
Extinction: sum of active levers before priming0.20.20.4-0.40.60.6-0.50.0-0.40.5-0.40.40.5-0.50.20.1
Active lever presses in extinction session 60.50.53.60.6-0.4-0.50.4-0.8-0.0-0.3-0.0-0.0-0.30.10.8-1.9
Bone: final force4.26.79.33.1-2.9-2.82.6-2.52.7-2.72.6-2.7-2.62.4-2.50.9
Bone: final moment3.35.47.02.6-2.6-2.62.2-2.22.6-2.52.4-2.4-2.42.1-2.30.6
Food consumed during 24 hour testing period0.70.92.11.4-0.5-0.60.9-1.40.7-0.60.7-0.8-0.70.91.3-0.9
Glucose0.20.43.2-1.8-0.5-0.5-0.20.70.0-0.1-0.10.5-0.0-0.1-0.2-0.3
Heart weight2.23.15.2-2.31.31.2-1.71.8-1.91.8-2.01.91.8-2.01.4-1.5
Delay discount hyperbolic model param0.30.30.80.20.80.9-0.40.1-0.80.8-0.60.40.7-0.60.10.4
Intermittent access intake day 1-15 change1.11.11.40.9-1.2-1.21.0-0.81.0-0.91.0-1.1-1.01.0-1.21.1
Intermittent access intake escalation1.61.52.01.0-1.4-1.41.3-1.11.2-1.11.3-1.4-1.21.4-1.01.2
Intermittent access intake escalation 20.10.10.7-0.8-0.4-0.40.20.2-0.10.1-0.0-0.0-0.00.10.10.4
Intermitt. access day 1 inactive lever presses0.30.31.6-0.50.50.6-0.10.7-0.20.5-0.20.20.5-0.3-0.61.3
Intermitt. access day 15 inactive lever presses1.41.52.60.9-1.0-1.01.4-1.01.3-1.11.3-1.3-1.21.4-1.41.6
Intermitt. access escalation Index0.50.41.0-0.30.80.8-0.81.0-0.70.8-0.60.50.7-0.50.30.4
Intermittent access day 1 total infusions0.40.41.4-1.20.20.1-0.80.7-0.50.3-0.70.70.3-0.60.1-1.0
Intermittent access day 15 total infusions0.20.20.8-0.0-0.8-0.80.3-0.10.4-0.50.3-0.4-0.50.4-0.90.1
Intermittent access terminal intake (last 3 days)0.40.41.1-0.2-1.0-1.00.3-0.20.5-0.70.4-0.5-0.70.5-1.00.1
Intermittent access total infusions0.10.10.5-0.7-0.4-0.4-0.20.2-0.1-0.1-0.30.2-0.1-0.2-0.3-0.7
Intermittent access day 1 locomotion0.20.20.30.1-0.4-0.40.5-0.30.5-0.50.4-0.3-0.50.5-0.50.1
Intermittent access day 15 total locomotion4.85.26.71.9-2.3-2.22.6-2.52.5-2.42.4-2.4-2.52.5-1.71.3
Intermittent access total locomotion1.92.23.21.2-1.5-1.51.8-1.81.7-1.61.5-1.5-1.61.5-0.80.2
Intermittent access standard deviation1.01.01.71.2-0.9-0.91.3-1.01.0-0.91.0-1.1-0.91.0-1.00.8
Left kidney weight3.08.411.81.9-3.2-3.23.4-2.92.9-3.02.9-2.9-3.13.2-3.11.5
Right kidney weight3.510.012.12.2-3.3-3.33.5-3.23.4-3.43.3-3.2-3.43.4-3.02.0
Cocaine induced anxiety0.10.10.90.10.50.5-0.10.2-0.10.4-0.00.10.3-0.10.00.9
Post-drug Anxiety0.30.31.20.30.60.6-0.50.4-0.50.7-0.40.40.6-0.41.1-0.2
Baseline Anxiety0.50.52.30.10.50.4-0.50.1-0.60.5-0.60.50.5-0.61.3-1.5
Tail length1.23.76.6-0.1-2.2-2.22.6-1.72.0-1.91.9-1.7-2.02.0-2.01.5
Length with tail2.48.713.80.8-3.5-3.53.7-2.93.0-3.23.0-2.8-3.33.3-2.61.3
Length without tail1.63.55.40.9-2.1-2.12.3-2.31.9-2.21.9-1.9-2.22.2-0.5-0.1
Times rat made contact with spout2.12.43.5-0.61.81.7-1.61.4-1.91.8-1.81.61.7-1.61.3-1.1
Lifetime Intake0.20.20.6-0.4-0.7-0.80.2-0.10.3-0.50.1-0.2-0.40.2-0.5-0.6
Liver weight, left4.77.610.42.1-2.8-2.83.0-2.93.2-3.03.1-2.9-3.03.2-1.61.5
Liver weight, right2.03.45.40.2-1.4-1.32.0-1.92.2-2.02.2-1.8-2.02.3-1.22.2
Locomotor activity0.40.63.50.40.40.50.2-0.10.6-0.20.5-0.4-0.20.3-1.51.9
Locomotor testing distance0.30.52.30.60.91.0-0.50.40.20.20.10.00.3-0.3-1.01.5
Locomotor testing rearing0.81.32.41.5-0.5-0.41.2-1.31.5-1.11.3-1.2-1.01.1-0.81.2
Locomotion in novel chamber0.70.81.4-1.01.21.2-1.21.1-0.70.8-0.80.90.9-1.00.3-0.2
Locomotion in novel chamber post-restriction1.72.13.31.6-1.2-1.31.4-1.81.5-1.61.6-1.7-1.61.7-0.70.4
Fecal boli incidents, locomotor time 10.30.32.00.3-0.3-0.30.1-0.50.1-0.2-0.0-0.1-0.1-0.21.0-1.4
Change in fecal boli incidents, locomotor task0.10.10.40.40.10.1-0.60.50.3-0.20.3-0.1-0.10.0-0.20.7
Time >=10cm from walls, locomotor time 11.41.44.02.0-0.8-0.71.4-1.21.1-1.01.4-1.4-1.11.40.10.7
Bouts of movement, locomotor time 10.20.30.80.10.90.9-0.40.3-0.50.6-0.40.30.6-0.50.40.2
Total resting periods, locomotor time 10.10.10.30.20.50.5-0.0-0.1-0.10.3-0.10.00.2-0.20.50.1
Rest time, locomotor task time 10.20.20.7-0.4-0.5-0.50.5-0.10.3-0.40.3-0.4-0.40.0-0.80.3
Distance moved, locomotor task time 10.20.20.80.9-0.3-0.20.0-0.60.3-0.30.4-0.5-0.40.50.40.2
Vertical activity count, locomotor time 10.80.93.41.8-0.6-0.60.4-1.20.7-0.70.9-1.0-0.80.81.1-0.4
Time >=10cm from walls, locomotor time 24.75.07.92.5-2.8-2.72.1-1.92.4-2.62.4-2.3-2.52.1-0.8-0.1
Bouts of movement, locomotor time 20.20.20.80.30.10.00.7-0.90.3-0.20.5-0.5-0.30.50.80.2
Total resting periods, locomotor time 20.10.10.8-0.20.50.50.1-0.3-0.20.3-0.10.00.3-0.10.90.1
Rest time, locomotor task time 20.20.21.3-0.40.60.60.30.20.10.20.0-0.10.2-0.2-0.61.1
Distance moved, locomotor task time 22.52.95.11.9-2.3-2.21.4-1.91.6-1.91.6-1.6-1.91.7-0.5-0.4
Vertical activity count, locomotor time 22.02.24.21.5-2.1-2.01.2-1.91.1-1.51.2-1.4-1.51.30.5-1.2
Light reinforcement 11.93.57.12.7-1.4-1.21.6-1.72.0-1.72.1-2.0-1.71.8-1.82.1
Light reinforcement 22.12.84.12.0-1.7-1.61.8-1.91.8-1.71.9-1.9-1.71.7-0.60.9
Bone: marrow area2.86.19.21.8-3.0-3.02.5-2.92.8-2.82.7-2.6-2.72.6-0.20.1
Bone: maximum diameter0.20.50.8-0.3-0.9-0.90.8-0.60.8-0.80.7-0.5-0.80.7-0.40.2
Bone: maximum force1.62.85.21.6-2.3-2.31.4-1.21.7-1.81.6-1.7-1.71.5-2.00.3
Bone: maximum moment1.22.04.01.2-2.0-2.01.1-0.91.5-1.61.3-1.3-1.51.2-1.7-0.0
Mean time between licks in bursts0.91.24.6-2.11.11.1-0.91.0-1.11.1-0.81.01.0-0.81.30.5
Mean num. licks in bursts0.20.21.70.40.10.0-0.2-0.0-0.50.3-0.50.30.3-0.40.4-1.3
Cd content in liver1.51.73.41.4-1.8-1.81.3-1.21.0-1.31.1-1.3-1.31.4-0.9-0.5
Co content in liver2.22.65.02.2-1.7-1.61.2-1.51.6-1.71.7-1.8-1.71.8-1.10.9
Cu content in liver2.53.04.4-0.81.61.5-2.12.0-2.11.9-2.11.81.9-2.10.3-1.1
Fe content in liver4.45.38.51.3-2.7-2.62.4-1.72.1-2.42.3-2.3-2.42.4-2.91.8
K content in liver1.31.33.7-1.90.80.8-1.31.4-1.31.1-1.11.21.1-1.00.8-0.1
Mg content in liver3.53.69.5-3.11.31.3-2.42.3-1.81.7-1.82.01.7-1.81.9-0.8
Mn content in liver0.40.42.2-1.40.20.2-0.50.4-0.40.4-0.30.50.3-0.31.5-0.4
Na content in liver0.10.11.00.10.20.20.1-0.0-0.50.3-0.1-0.00.2-0.0-0.41.0
Rb content in liver0.20.31.00.3-0.7-0.80.2-0.40.5-0.50.3-0.3-0.50.40.5-1.0
Se content in liver3.44.112.3-3.51.61.5-2.32.5-2.11.9-1.92.11.9-1.61.5-0.2
Sr content in liver0.30.32.10.1-0.3-0.4-0.2-0.2-0.10.0-0.20.10.0-0.20.9-1.4
Zn content in liver0.50.61.5-0.5-1.1-1.20.4-0.01.2-0.90.6-0.3-0.70.6-0.9-0.3
Bone: minimum diameter0.91.62.70.7-1.7-1.61.3-1.31.5-1.51.4-1.3-1.41.3-0.60.1
Time in familiar zone, hab. session 10.10.10.40.2-0.1-0.1-0.40.40.1-0.0-0.10.10.0-0.1-0.7-0.1
Time in novel zone, hab. session 10.20.20.30.2-0.6-0.50.3-0.30.4-0.50.5-0.5-0.50.3-0.30.5
Total zone transitions, hab. session 12.63.76.7-1.82.22.2-2.32.6-1.92.0-1.91.92.0-1.8-0.10.8
Total locomotion distance, hab. session 12.12.95.3-2.02.12.0-1.92.3-1.61.7-1.61.71.7-1.50.10.8
Locomotion velocity, hab. session 12.02.85.1-2.22.01.9-1.82.3-1.51.6-1.61.71.7-1.40.10.8
Time in familiar zone, hab. session 21.41.54.3-0.52.02.1-0.50.4-1.01.4-1.01.11.4-1.21.20.0
Time in novel zone, hab. session 21.81.85.50.7-2.3-2.30.6-0.61.1-1.61.1-1.2-1.51.2-0.9-0.6
Total zone transitions, hab. session 20.70.92.2-0.61.31.4-0.71.0-0.80.9-0.60.70.9-0.7-0.81.5
Total locomotion distance, hab. session 22.73.67.4-1.62.72.7-1.62.0-1.82.1-1.71.82.1-1.70.01.3
Locomotion velocity, hab. session 23.24.38.9-1.93.03.0-1.82.2-2.02.3-1.92.02.3-1.80.11.3
Novel to familiar place preference ratio0.40.41.60.1-0.8-0.80.20.10.6-0.70.5-0.5-0.60.5-1.30.4
Novelty place preference0.30.31.30.1-0.7-0.70.20.10.6-0.60.4-0.5-0.60.5-1.20.4
Time in novel zone, NPP test0.40.40.90.1-0.8-0.80.4-0.10.6-0.70.5-0.5-0.60.6-0.90.2
Total zone transitions, NPP test1.62.33.3-1.81.61.6-1.61.8-1.61.6-1.61.71.6-1.70.3-0.1
Total locomotion distance, NPP test1.21.72.2-1.31.41.4-1.31.3-1.31.4-1.41.51.4-1.40.7-0.7
Locomotion velocity, NPP test1.92.64.0-1.42.02.0-1.51.6-1.71.8-1.71.81.8-1.70.7-0.5
Intraocular pressure1.01.41.90.6-1.3-1.31.2-1.01.2-1.41.3-1.1-1.31.4-1.10.8
Delta distance traveled before/after self-admin0.40.51.9-0.20.30.2-0.40.4-0.80.7-0.80.70.6-0.61.0-1.4
Delta ambulatory time before/after self-admin0.50.61.8-0.20.40.4-0.70.2-0.80.8-0.80.70.7-0.71.3-1.2
Parametrial fat weight2.14.16.92.5-1.3-1.21.8-1.82.2-1.82.2-2.2-1.92.2-2.12.6
Pavlov. Cond. lever latency1.01.36.12.5-0.2-0.21.7-2.10.8-0.50.8-0.9-0.60.80.3-0.4
Pavlov. Cond. magazine entry latency0.91.24.1-2.00.60.6-1.51.5-0.80.7-0.91.10.8-1.00.6-0.5
Pavlov. Cond. change in total contacts0.50.51.2-0.6-0.9-0.8-0.50.60.7-0.80.7-0.6-0.80.6-0.81.1
Pavlov. Cond. index score0.70.95.1-2.30.10.1-1.41.7-0.50.3-0.60.80.4-0.7-0.3-0.0
Pavlov. Cond. latency score0.70.84.7-2.20.10.1-1.31.6-0.40.2-0.50.80.4-0.7-0.40.1
Pavlov. Cond. lever contacts0.80.94.6-2.1-0.0-0.0-1.41.7-0.60.4-0.70.80.4-0.8-0.4-0.1
Pavlov. Cond. magazine entry number1.31.63.61.9-1.0-1.01.7-1.71.2-1.11.2-1.3-1.11.3-0.70.4
Pavlov. Cond. intertrial magazine entries0.20.21.30.8-0.6-0.70.3-0.4-0.1-0.1-0.1-0.2-0.20.20.2-1.1
Pavlov. Cond. lever-magazine prob. diff.0.81.05.1-2.3-0.1-0.1-1.51.8-0.40.2-0.60.80.3-0.7-0.40.0
Pavlov. Cond. response bias1.51.86.4-2.50.60.6-1.82.0-1.20.9-1.31.41.0-1.30.5-0.6
Pavlov. Cond. lever latency1.82.53.51.7-1.6-1.51.4-1.41.5-1.51.7-1.9-1.61.6-1.41.7
Pavlov. Cond. magazine entry latency0.50.51.60.3-0.7-0.80.9-1.10.5-0.60.4-0.3-0.60.60.8-1.3
Pavlov. Cond. change in total contacts1.21.62.8-0.91.31.3-1.00.8-1.31.2-1.31.41.2-1.21.6-1.7
Pavlov. Cond. index score0.50.62.2-0.80.60.6-0.40.3-0.70.6-0.80.90.6-0.61.3-1.5
Pavlov. Cond. latency score0.30.41.5-0.60.50.5-0.30.1-0.50.5-0.60.70.5-0.51.1-1.2
Pavlov. Cond. lever contacts1.21.62.1-1.01.41.3-1.21.1-1.11.2-1.41.51.3-1.31.0-1.4
Pavlov. Cond. magazine entry number0.20.31.1-0.40.20.3-0.60.8-0.30.3-0.20.20.3-0.3-0.81.0
Pavlov. Cond. intertrial magazine entries0.71.02.3-1.01.01.1-1.20.9-1.11.0-0.70.71.0-0.71.50.4
Pavlov. Cond. lever-magazine prob. diff.0.30.42.0-0.50.50.4-0.20.0-0.40.4-0.50.60.4-0.41.2-1.4
Pavlov. Cond. response bias0.71.03.0-1.00.80.7-0.80.7-0.80.8-1.01.10.8-0.81.1-1.7
Time in closed arm before self-admin0.40.51.6-0.50.40.3-0.50.7-0.80.6-0.70.70.6-0.41.3-1.2
Time in closed arm after self-admin0.10.10.30.1-0.5-0.60.20.40.1-0.30.2-0.1-0.30.5-0.5-0.2
Time in open arm before self-admin0.20.20.9-1.00.30.4-0.50.4-0.30.4-0.40.50.4-0.6-0.10.3
Time in open arm after self-admin1.51.72.8-1.41.31.3-1.20.5-1.31.3-1.41.31.3-1.71.5-1.2
Bone: periosteal estimation1.73.55.41.3-2.3-2.31.8-1.82.2-2.12.0-1.9-2.11.9-1.10.5
Bone: periosteal perimeter0.60.91.31.0-0.8-0.71.1-1.11.1-1.01.1-1.0-1.01.0-0.60.7
Bone: post-yield work0.40.61.9-0.2-1.4-1.40.4-0.60.3-0.70.4-0.5-0.70.50.4-1.1
Progressive ratio test 1 active lever presses0.00.10.4-0.20.10.00.0-0.0-0.0-0.0-0.20.20.0-0.2-0.4-0.6
Progressive ratio test 1 breakpoint0.10.10.4-0.20.10.1-0.00.0-0.10.0-0.30.30.1-0.2-0.3-0.7
Progressive ratio test 1 inactive lever presses1.01.12.71.2-0.9-0.91.0-0.51.1-0.91.0-1.0-0.91.0-1.61.0
Progressive ratio test 2 active lever presses0.00.00.30.3-0.1-0.10.10.10.0-0.00.0-0.1-0.00.1-0.60.1
Progressive ratio test 2 breakpoint0.10.10.60.2-0.0-0.0-0.00.3-0.10.0-0.10.00.1-0.1-0.80.3
Progressive ratio test 2 inactive lever presses0.10.10.5-0.70.00.1-0.40.6-0.40.3-0.40.30.3-0.2-0.20.2
Incentive Sensitization - Responses0.80.91.5-0.31.21.2-1.01.1-1.01.1-0.80.81.0-0.9-0.20.8
Incentive Sensitization - Breakpoint0.50.51.1-0.10.90.9-0.70.8-0.70.8-0.50.50.8-0.6-0.51.0
Sum of active levers in priming session hrs 5-60.40.41.1-1.1-0.1-0.2-0.60.5-0.60.5-0.80.70.4-0.60.4-1.0
Progressive ratio3.64.17.62.8-1.5-1.52.3-2.32.0-1.92.2-2.3-1.92.4-1.51.5
Food seeking constrained by brief footshock0.20.21.20.10.40.40.50.0-0.30.2-0.30.30.2-0.00.7-1.1
Seeking ratio, punishment vs. effort2.32.84.9-2.21.31.2-1.62.0-1.71.6-1.92.01.7-1.91.1-1.4
Retroperitoneal fat weight1.24.05.92.2-1.8-1.82.4-2.22.2-2.12.1-2.0-2.02.0-1.90.9
Reaction time number correct0.81.23.51.9-0.3-0.31.3-1.11.0-0.91.1-1.1-0.91.0-1.21.1
Reaction time mean minus median0.20.30.6-0.8-0.6-0.60.4-0.40.4-0.50.5-0.4-0.50.40.70.2
Reaction time mean minus median AUC0.30.41.6-0.9-0.7-0.70.3-0.30.4-0.60.4-0.3-0.60.41.2-0.7
Reaction time num false alarms0.20.31.2-0.80.80.9-0.30.3-0.10.5-0.20.40.4-0.2-0.21.1
Reaction time num false alarms AUC0.71.02.3-1.21.51.5-0.70.8-0.71.1-0.81.01.0-0.80.10.9
Reaction time trials correct on left0.81.23.51.9-0.3-0.31.3-1.11.0-0.91.1-1.1-0.91.0-1.21.1
Reaction time trials on left0.81.13.41.8-0.3-0.21.3-1.11.0-0.91.1-1.1-0.91.0-1.11.1
Reaction time mean0.40.52.7-0.7-0.8-0.80.2-0.40.5-0.60.4-0.4-0.60.21.6-1.0
Reaction time mean AUC0.60.82.4-0.4-1.1-1.10.5-0.70.9-0.90.8-0.7-0.90.51.5-0.9
Median of all reaction times0.30.52.4-0.3-0.7-0.60.2-0.50.5-0.60.5-0.5-0.60.21.5-0.9
Reaction time omissions0.10.10.8-0.10.30.40.2-0.20.00.00.2-0.2-0.00.20.90.5
Reaction time false alarm rate1.42.05.3-2.31.41.4-1.41.5-1.31.5-1.41.61.4-1.30.70.1
Reaction time premature initiation rate0.20.30.7-0.10.60.7-0.80.5-0.50.5-0.40.20.5-0.60.70.0
Reaction time premature initiations0.10.21.11.10.30.40.1-0.30.2-0.20.3-0.5-0.20.10.00.6
Std. dev. reaction times0.30.42.3-1.2-0.5-0.50.3-0.30.1-0.20.1-0.1-0.30.11.5-0.8
Reaction time trials completed0.81.13.41.8-0.3-0.21.3-1.11.0-0.91.1-1.1-0.91.0-1.11.1
Reaction time trials AUC0.81.13.51.9-0.3-0.31.3-1.20.9-0.91.1-1.1-0.91.0-1.01.0
Run reversals in cocaine runway, females0.40.41.00.3-0.9-1.00.1-0.60.6-0.70.3-0.3-0.60.3-0.6-0.8
Run reversals in cocaine runway, males0.40.40.9-0.9-0.9-0.90.30.00.6-0.50.4-0.5-0.60.4-0.40.8
Latency to leave start box in cocaine runway0.60.61.9-0.60.50.4-0.81.4-1.00.8-0.80.80.8-0.70.5-0.5
Latency to leave start box in cocaine runway, F0.50.61.1-0.60.70.7-0.70.8-1.00.8-0.80.90.8-0.70.7-0.6
Latency to leave start box in cocaine runway, M0.20.20.9-0.0-0.2-0.1-0.31.0-0.10.1-0.1-0.00.1-0.2-0.70.7
Std. dev. time between licks in bursts0.40.52.8-1.70.20.3-0.10.50.5-0.20.30.1-0.10.0-0.61.5
Total sessions with >9 infusions0.10.10.4-0.3-0.2-0.2-0.0-0.00.2-0.30.00.1-0.2-0.1-0.2-0.7
Short access day 1 total inactive lever presses0.20.20.9-0.9-0.4-0.50.10.4-0.30.1-0.30.30.00.00.1-0.6
Short access day 10 total inactive lever presses0.50.65.00.60.70.80.10.40.30.30.3-0.20.20.1-0.92.2
Short access day 1 total infusions0.91.02.6-1.60.60.6-1.01.1-0.90.8-1.11.20.9-1.00.1-0.9
Short access day 10 total infusions0.00.00.1-0.10.10.10.3-0.1-0.00.0-0.10.00.0-0.00.1-0.3
Short access total infusions0.10.10.4-0.6-0.4-0.50.00.00.1-0.2-0.10.1-0.20.0-0.3-0.6
Short access day 1 locomotion0.30.31.0-0.20.70.7-0.30.5-0.10.4-0.30.50.5-0.4-1.00.7
Short access day 10 total locomotion0.60.62.0-0.51.41.4-0.30.2-0.61.0-0.70.80.9-0.50.30.5
Short access total locomotion0.00.00.10.10.30.30.4-0.40.10.10.00.10.00.20.20.0
One hour access (0.3 mA shock)0.60.71.4-1.20.70.7-0.70.9-1.00.9-1.01.00.9-0.90.2-0.3
Compulsive drug intake2.52.53.5-1.41.41.3-1.21.1-1.81.7-1.81.71.7-1.61.9-1.7
One hour access (shock baseline)0.30.40.8-0.2-0.9-0.90.6-0.60.6-0.70.5-0.6-0.70.6-0.4-0.0
Social response proportion0.00.00.1-0.20.0-0.00.2-0.10.1-0.0-0.00.10.0-0.00.1-0.4
Social responses0.20.31.00.01.01.0-0.20.2-0.10.5-0.20.40.5-0.3-0.00.6
Social time0.40.61.2-0.91.01.1-0.60.6-0.40.7-0.30.60.6-0.40.81.0
Soleus weight0.20.62.0-1.4-0.8-0.80.5-0.40.9-0.80.8-0.4-0.80.70.40.5
Bone: stiffness1.11.82.51.6-1.6-1.51.0-1.11.5-1.51.4-1.4-1.41.2-1.40.6
Tibialis anterior weight0.82.74.9-0.62.22.2-1.71.5-1.71.8-1.71.61.8-1.51.3-0.7
Time to tail flick, vehicle, before self-admin2.02.07.71.3-0.7-0.60.8-0.61.6-1.21.7-1.6-1.31.5-1.12.8
Time to tail flick, vehicle, after self-admin0.10.10.40.20.50.4-0.30.2-0.40.5-0.40.30.4-0.30.6-0.4
Time to tail flick, test, before self-admin0.50.52.80.31.01.0-0.00.6-0.30.5-0.10.20.50.0-1.01.7
Time to tail flick, test, after self-admin0.10.10.5-0.0-0.2-0.2-0.20.70.1-0.00.1-0.1-0.10.2-0.50.6
Delta time to tail flick, vehicle, before/after SA1.41.36.2-0.70.50.4-0.80.5-1.30.9-1.31.21.0-1.31.0-2.5
Delta time to tail flick, test, before/after SA1.41.32.91.0-1.7-1.70.7-0.61.3-1.31.1-1.2-1.30.9-0.7-0.1
Tibia length2.46.88.91.8-3.0-2.92.9-2.82.6-2.82.9-2.8-2.93.0-1.21.4
Ambulatory time before self-admin0.60.62.60.70.30.40.9-0.90.6-0.40.8-0.7-0.50.8-0.51.6
Ambulatory time after self-admin0.30.41.20.41.11.10.1-0.8-0.20.6-0.20.10.40.10.90.6
Bone: tissue strength0.10.10.70.4-0.2-0.30.3-0.30.0-0.1-0.1-0.0-0.1-0.1-0.1-0.8
Total heroin consumption0.40.52.3-0.30.80.8-0.6-0.5-0.60.8-0.60.50.6-0.41.5-0.4
Bone: trabecular number0.71.11.9-0.90.80.8-1.01.1-1.41.2-1.31.11.1-1.00.7-1.0
Bone: trabecular spacing1.62.03.21.4-1.2-1.21.6-1.71.8-1.51.6-1.5-1.51.4-0.70.7
Bone: trabecular thickness0.50.61.50.1-1.2-1.20.7-0.50.6-0.80.6-0.6-0.80.8-0.5-0.4
Bone: trabecular tissue density0.10.20.4-0.6-0.5-0.50.6-0.20.1-0.30.2-0.2-0.40.4-0.50.2
Water consumed over 24 hours1.31.53.0-0.51.31.2-1.10.8-1.41.3-1.31.21.3-1.11.7-1.3
Number of responses in last shaping day1.31.35.6-2.4-0.0-0.1-1.11.6-1.00.8-1.31.30.8-1.0-0.0-1.2