Hub : Genes

Brme1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Brme1 0.06 0.03 7.8e-05 0.04 0.05 0.05 0.04 5.3e-05 3.5e-05 3.5e-05 4.8e-05
2 Liver mRNA stability Brme1 0.1 0.05 2.0e-11 0.11 0.09 0.1 0.1 1.9e-12 1.6e-10 9.3e-11 3.6e-11
3 BLA mRNA stability Brme1 0.09 0.05 8.7e-03 0.02 0.02 0.02 0.02 3.9e-02 1.8e-02 2.8e-02 2.3e-02
4 Adipose mRNA stability Brme1 0.12 0.05 7.2e-09 0.07 0.08 0.07 0.04 2.5e-08 8.3e-09 2.0e-08 2.4e-05
5 NAcc mRNA stability Brme1 0.02 0.01 1.2e-03 0.01 0.01 0.01 0 3.8e-02 9.6e-03 4.2e-02 7.6e-02
6 pVTA mRNA stability Brme1 0.05 0.03 3.3e-03 0.03 0.01 0.01 0.02 3.6e-03 2.9e-02 6.0e-02 1.5e-02
7 IC gene expression Brme1 0.13 0.09 6.5e-03 0.06 0 0.04 0.01 2.2e-03 3.0e-01 6.3e-03 1.6e-01
8 NAcc gene expression Brme1 0.02 0.01 2.9e-03 0.01 0.02 0.02 0.02 1.9e-03 1.4e-03 1.3e-03 6.7e-04
9 Brain gene expression Brme1 0.04 0.02 4.2e-03 0.01 0 0 0 4.4e-02 1.0e-01 1.7e-01 1.2e-01
10 BLA intron excision ratio chr19_40905029_40916187 0.1 0.05 9.6e-05 0.09 0.06 0.06 0.06 2.4e-05 5.5e-04 4.5e-04 3.6e-04
11 Liver gene expression Brme1 0.07 0.04 1.3e-04 0.03 0.01 0.01 0.01 1.3e-04 1.7e-02 3.9e-02 1.1e-02
12 BLA isoform ratio XM_039098080.2 0.05 0.03 7.6e-03 0.03 0.03 0.01 0.02 1.4e-02 1.5e-02 7.2e-02 3.8e-02
13 Liver isoform ratio NM_001400966.1 0.02 0.02 9.2e-03 0 0 -0 0 7.6e-02 1.4e-01 5.5e-01 3.1e-01
14 Adipose isoform ratio XR_005496718.2 0.12 0.05 1.8e-10 0.09 0.08 0.07 0.08 6.5e-10 8.7e-09 1.8e-08 2.4e-09
15 Adipose alternative polyA XM_063277963.1 0.03 0.02 3.8e-04 0.03 0.02 0.04 0.03 6.2e-04 2.3e-03 6.8e-05 4.1e-04
16 pVTA gene expression Brme1 0.06 0.03 2.2e-05 0.03 0.06 0.05 0.06 2.0e-03 6.7e-06 4.7e-05 1.2e-05
17 PL intron excision ratio chr19_40902378_40904855 0.06 0.03 3.2e-05 0.04 0.04 0.03 0.04 1.5e-05 8.1e-05 2.7e-04 9.3e-05
18 Adipose alternative polyA NM_001400966.1 0.04 0.02 4.2e-04 0.03 0.02 0.04 0.03 7.6e-04 2.9e-03 8.2e-05 4.5e-04
19 PL gene expression Brme1 0.12 0.06 8.8e-09 0.07 0.08 0.09 0.09 1.1e-07 2.3e-09 9.7e-10 1.4e-09
20 Adipose gene expression Brme1 0.04 0.02 2.0e-03 0.01 0.02 0.01 0.01 4.7e-02 4.0e-03 1.3e-02 9.0e-03
21 BLA gene expression Brme1 0.25 0.09 1.4e-09 0.13 0.16 0.14 0.16 1.5e-07 7.8e-09 5.7e-08 9.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21
Bone: apparent density2.23.79.5-2.6-3.1-2.7-2.7-2.2-1.92.4-0.9-0.73.0-0.82.32.21.21.91.01.5-1.8-0.4-0.20.8
Area under the delay curve0.30.41.30.60.50.20.60.20.21.10.80.90.80.90.60.50.30.30.90.3-0.30.70.60.4
BMI with tail1.44.713.72.33.12.51.73.63.3-3.70.60.7-1.90.6-2.5-1.70.9-2.7-1.7-2.22.4-0.3-1.0-0.1
BMI without tail0.10.41.70.30.50.30.41.00.8-1.00.60.70.60.70.10.61.0-0.10.20.20.00.50.31.3
Body weight0.10.44.0-0.10.60.00.40.30.0-2.0-0.3-0.2-0.9-0.3-0.8-0.3-0.4-0.2-1.0-0.00.10.0-0.10.9
Weight adjusted by age0.20.31.11.10.90.70.40.40.40.60.30.1-0.40.1-0.3-0.6-0.4-0.60.2-0.50.6-0.1-0.0-1.0
Bone surface2.24.08.6-2.3-2.6-2.2-1.4-2.7-1.92.20.50.52.70.52.92.3-0.62.32.02.6-2.11.21.41.7
Bone volume2.24.08.6-2.7-2.9-2.4-1.9-2.8-2.02.00.10.32.70.12.92.2-0.52.31.72.4-2.10.81.01.4
Breakpoint value in progressive ratio session1.82.15.3-0.7-0.0-0.5-1.20.3-0.1-1.7-2.3-2.0-1.5-2.1-1.6-1.40.6-0.6-2.3-1.60.5-2.1-2.0-1.2
Number of licking bursts0.30.53.5-0.6-0.5-0.9-0.6-0.0-0.70.1-0.8-0.60.7-0.6-0.11.01.90.7-0.40.2-0.8-0.4-0.41.0
Context. condit. distance diff. score0.60.72.61.31.61.21.51.30.3-0.80.30.2-1.20.2-1.4-0.60.20.0-0.5-0.7-0.20.20.20.1
Locomotion velocity, session 10.70.82.5-1.6-1.4-1.5-1.3-1.2-0.80.1-0.4-0.21.0-0.31.10.9-0.00.80.20.9-0.80.2-0.10.8
Locomotion distance, session 10.40.51.5-1.1-0.7-1.0-0.9-0.3-0.3-0.5-1.2-0.60.2-0.8-0.40.51.0-0.0-0.80.0-0.1-0.6-0.70.5
Locomotion velocity, session 20.50.51.5-0.7-0.9-1.0-0.8-0.6-0.90.8-0.6-0.21.0-0.20.31.01.20.80.10.4-0.8-0.1-0.10.6
Locomotion distance, session 20.50.61.9-0.60.0-0.5-0.50.3-0.0-1.4-1.4-0.8-0.6-0.9-1.2-0.01.1-0.4-1.4-0.60.2-1.0-1.00.3
Locomotion velocity, session 30.10.20.50.10.20.40.50.10.4-0.10.70.50.10.50.40.1-0.50.10.60.3-0.10.60.60.3
Locomotion distance, session 32.02.15.1-0.2-0.4-0.40.9-0.8-0.81.51.41.21.71.31.62.10.51.72.01.9-1.71.72.02.3
Stereotopy head waving bouts, day 31.41.65.01.40.91.31.60.51.10.02.22.20.22.00.90.1-1.3-0.31.60.80.41.81.60.7
Stereotopy head waving duration, day 30.50.61.61.10.81.01.00.81.0-0.11.21.30.01.10.1-0.1-0.3-0.50.60.10.60.80.60.2
Locomotion velocity, session 70.20.31.00.30.70.51.00.50.1-0.50.50.3-0.10.4-0.20.40.40.40.30.2-0.50.60.71.0
Locomotion distance, session 70.20.30.8-0.8-0.4-0.7-0.5-0.3-0.5-0.4-0.9-0.80.0-0.8-0.30.30.70.2-0.5-0.0-0.3-0.5-0.40.3
Stereotopy head waving bouts, day 71.82.14.70.6-0.10.21.2-0.4-0.41.71.81.81.51.81.51.60.11.42.21.6-1.32.02.01.7
Stereotopy head waving duration, day 71.51.83.7-0.1-0.7-0.40.4-0.7-0.71.91.31.21.81.31.71.80.41.61.91.6-1.51.51.61.6
Locomotion velocity, session 80.20.31.3-0.70.0-0.4-0.1-0.3-0.6-1.2-0.7-0.5-0.8-0.6-0.6-0.2-0.40.3-0.8-0.0-0.4-0.2-0.30.2
Locomotion distance, session 80.40.62.40.10.70.10.40.8-0.1-1.3-1.0-0.6-0.9-0.8-1.6-0.11.20.0-1.3-0.7-0.2-0.7-0.60.4
Degree of sensitization distance1.81.94.3-0.50.1-0.2-1.00.40.2-1.6-1.8-1.6-1.5-1.7-1.6-1.5-0.0-1.2-2.1-1.51.2-1.8-1.9-1.6
Degree of sensitization stereotypy1.01.12.50.4-0.00.10.9-0.2-0.21.31.21.31.21.51.01.30.41.01.61.1-0.91.51.51.3
Conditioned locomotion0.10.10.4-0.6-0.2-0.4-0.3-0.5-0.4-0.2-0.4-0.3-0.1-0.40.10.1-0.30.3-0.30.2-0.3-0.2-0.10.1
Cocaine response after cond. corrected0.91.03.8-0.10.70.2-0.20.70.2-1.9-1.1-1.1-1.5-1.2-1.5-1.10.0-0.5-1.7-1.10.4-1.2-1.2-0.7
Cocaine response after cond. not corrected1.21.54.2-0.30.5-0.0-0.60.70.0-2.0-1.5-1.5-1.4-1.6-1.6-1.10.4-0.5-2.0-1.40.3-1.6-1.6-0.9
Cocaine response before conditioning0.30.30.9-0.4-0.7-0.7-0.5-0.5-0.60.7-0.1-0.11.0-0.00.60.80.70.70.40.5-0.70.00.10.5
Saline control response1.92.66.3-2.5-1.6-2.3-2.0-1.2-1.60.3-2.5-2.50.5-2.5-0.40.91.80.9-1.40.0-1.0-1.8-1.40.3
Bone: connectivity density3.55.514.8-2.6-3.4-2.9-2.4-2.7-2.33.2-0.3-0.13.8-0.23.13.11.32.61.92.3-2.40.30.71.7
Bone: cortical apparent density0.50.72.21.40.70.71.01.10.70.71.01.10.91.00.10.91.50.00.80.1-0.10.60.60.9
Bone: cortical area0.20.31.1-1.0-0.2-0.7-0.1-0.6-0.6-0.4-0.6-0.5-0.2-0.6-0.20.5-0.00.6-0.30.5-0.6-0.10.10.7
Bone: cortical porosity0.60.72.60.41.00.90.90.30.5-0.4-0.1-0.3-1.6-0.1-1.1-1.3-1.1-0.9-0.6-0.71.0-0.2-0.1-1.1
Bone: cortical porosity0.40.41.80.20.90.71.2-0.10.2-0.10.30.0-1.30.2-0.6-0.8-1.3-0.4-0.1-0.10.50.30.5-0.5
Bone: cortical thickness0.50.82.50.81.60.91.21.20.9-1.3-0.1-0.1-1.3-0.2-1.6-0.50.4-0.7-0.9-0.70.6-0.2-0.20.2
Bone: cortical thickness3.54.211.7-0.20.4-0.4-1.41.70.8-0.6-2.8-2.7-0.6-2.8-2.6-0.73.4-1.3-2.7-2.61.1-3.3-3.0-1.5
Bone: cortical tissue density0.60.82.01.40.70.71.01.00.60.71.11.21.01.20.21.01.40.21.00.2-0.30.80.81.1
Condit. Reinf. active minus inactive responses2.52.810.11.51.61.33.20.50.00.82.32.00.21.90.11.40.10.81.91.4-0.82.32.72.5
Condit. Reinf. active-inactive response ratio0.80.95.51.21.71.22.30.90.20.10.90.7-0.70.5-0.90.40.50.00.40.1-0.10.81.31.1
Condit. Reinf. active responses1.82.35.91.00.90.72.30.0-0.31.32.02.00.81.90.71.60.10.92.01.5-0.82.22.42.2
Condit. Reinf. inactive responses1.41.73.7-1.2-1.6-1.4-0.9-1.7-1.31.70.40.61.90.71.91.6-0.11.31.41.7-1.20.90.91.1
Incentive salience index mean2.63.28.50.50.30.32.1-0.6-0.61.42.22.21.32.01.42.1-0.31.42.52.3-1.32.52.92.7
Condit. Reinf. lever presses2.33.26.4-0.4-1.0-0.70.6-1.6-1.21.71.71.92.11.62.32.2-0.71.82.52.5-1.62.22.42.2
Condit. Reinf. active minus inactive responses0.30.41.1-0.6-0.4-0.20.3-0.7-0.2-0.30.50.80.20.60.60.5-1.10.50.61.0-0.41.00.80.9
Condit. Reinf. active-inactive response ratio0.10.21.0-0.10.20.30.3-0.00.3-0.60.10.1-0.70.2-0.2-0.6-1.0-0.4-0.2-0.10.40.20.1-0.4
Condit. Reinf. active responses0.10.10.6-0.8-0.4-0.4-0.3-0.40.1-0.7-0.20.2-0.1-0.20.10.2-0.50.1-0.10.4-0.10.20.00.4
Condit. Reinf. inactive responses0.40.51.1-0.30.0-0.1-0.60.30.6-1.0-0.9-0.5-0.6-1.0-0.8-0.60.3-0.8-1.0-0.70.8-1.0-1.0-0.6
Condit. Reinf. lever presses0.10.10.50.20.10.30.10.30.5-0.50.30.7-0.00.4-0.0-0.2-0.2-0.20.1-0.10.30.20.0-0.1
Condit. Reinf. lever reinforcers received0.00.10.3-0.6-0.3-0.2-0.2-0.30.2-0.4-0.10.4-0.0-0.00.10.1-0.5-0.10.00.30.10.20.00.1
Conditioned reinforcement - actives0.00.00.1-0.4-0.2-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.0-0.1-0.40.2-0.20.1-0.2-0.1-0.1-0.1
Conditioned reinforcement - inactives0.10.10.60.2-0.10.40.4-0.1-0.0-0.10.40.4-0.20.4-0.0-0.0-0.80.10.30.40.00.50.4-0.0
Conditioned locomotion0.10.20.40.20.00.20.20.20.3-0.60.70.60.20.70.30.3-0.20.20.30.5-0.30.70.30.6
Patch foraging indifference point 0 sec0.40.72.20.10.50.31.4-0.40.1-0.10.81.4-0.21.00.60.6-1.10.10.80.9-0.11.21.51.3
Patch foraging indifference point AUC0.81.24.2-1.8-1.7-1.8-2.0-1.3-1.20.2-1.3-1.10.8-1.10.50.30.10.8-0.40.3-0.8-0.7-0.9-0.2
Delay disc. indifference point, 0s delay0.70.82.4-1.1-0.9-1.1-1.0-1.1-0.70.40.40.41.30.31.50.8-0.61.00.71.1-1.00.60.30.8
Delay disc. indifference point, 16s delay0.60.61.50.81.20.80.31.20.8-0.9-0.2-0.2-0.8-0.2-1.1-0.90.2-0.6-0.8-1.00.5-0.5-0.8-0.9
Delay disc. indifference point, 2s delay0.50.51.91.10.81.01.10.60.71.40.90.90.10.90.1-0.10.30.00.8-0.20.00.50.6-0.3
Delay disc. indifference point, 24s delay0.40.52.30.91.10.81.50.30.0-0.00.70.7-0.30.8-0.2-0.3-0.80.10.40.1-0.10.90.90.4
Delay disc. indifference point, 4s delay1.21.25.7-0.3-0.8-0.5-0.3-0.6-0.32.40.90.91.90.91.71.40.81.11.60.9-1.00.80.80.6
Delay disc. indifference point, 8s delay0.50.61.61.01.00.40.90.40.50.61.21.30.81.20.50.50.1-0.10.90.40.11.10.90.8
Indifference point function ln k1.32.37.11.92.12.02.71.31.6-0.22.32.2-0.32.20.10.1-0.8-0.51.30.40.61.81.81.0
Indifference point function log k1.32.37.11.92.12.02.71.31.6-0.22.32.2-0.32.20.10.1-0.8-0.51.30.40.61.81.81.0
Patch foraging total patch changes 0 sec0.40.72.30.50.80.71.5-0.00.5-0.50.81.4-0.61.00.20.1-1.1-0.40.50.50.41.11.31.0
Patch foraging total patch changes 12 sec0.91.23.2-1.3-1.3-1.6-0.5-1.5-1.60.5-0.7-0.21.0-0.50.81.60.51.30.31.2-1.40.30.61.8
Patch foraging total patch changes 18 sec1.42.16.8-2.6-2.3-2.4-1.8-2.1-1.70.9-1.2-0.51.4-0.91.11.60.71.30.21.3-1.3-0.2-0.11.2
Patch foraging total patch changes 24 sec0.91.53.3-1.5-1.6-1.5-0.6-1.8-1.60.9-0.2-0.11.3-0.11.41.7-0.41.40.91.7-1.40.60.91.5
Patch foraging total patch changes 6 sec0.20.31.0-1.0-0.8-1.0-0.8-0.8-0.50.5-0.7-0.30.4-0.70.40.50.40.3-0.10.2-0.3-0.4-0.20.2
Patch foraging time to switch 0 sec0.10.31.0-0.4-0.4-0.5-0.4-0.2-0.60.6-0.7-0.70.2-0.7-0.20.41.00.5-0.3-0.0-0.5-0.6-0.30.0
Patch foraging water rate 0 sec0.20.41.5-0.20.30.3-0.10.10.7-1.2-0.20.1-0.8-0.1-0.4-0.8-1.2-0.9-0.5-0.40.9-0.0-0.3-0.4
Patch foraging water rate 12 sec0.51.13.71.00.51.00.90.81.20.51.81.90.81.80.70.60.4-0.41.40.50.51.41.00.7
Patch foraging water rate 18 sec1.82.86.90.4-0.40.31.1-0.50.21.42.42.31.72.32.11.8-0.81.02.62.1-0.92.52.31.8
Patch foraging water rate 24 sec1.11.64.21.00.70.91.50.30.50.52.02.00.81.91.11.1-0.40.51.71.1-0.41.91.81.4
Patch foraging water rate 6 sec1.62.37.2-2.7-2.4-2.4-2.3-1.8-1.60.8-1.1-1.31.7-1.21.31.50.81.40.11.2-1.5-0.5-0.50.8
Seeking ratio, delayed vs. immediate footshock1.01.24.11.61.71.30.91.91.7-0.30.90.60.00.6-0.80.12.0-1.3-0.1-1.01.2-0.4-0.3-0.2
Distance traveled before self-admin0.50.61.91.01.01.41.10.71.00.60.60.6-0.90.6-0.6-0.6-0.7-0.90.3-0.51.00.20.2-1.2
Distance traveled after self-admin0.40.51.41.10.51.20.70.80.90.20.60.5-0.80.6-0.7-0.3-0.4-0.70.2-0.20.80.2-0.0-1.1
Extensor digitorum longus weight0.31.33.1-0.10.70.30.00.50.3-1.7-1.2-1.3-1.8-1.3-1.7-1.3-0.2-1.1-1.7-1.21.1-1.2-1.1-1.0
Bone: elastic displacement0.70.82.00.90.90.91.40.50.8-0.91.31.3-0.31.4-0.00.1-0.8-0.10.60.60.01.41.10.9
Bone: elastic work1.01.44.11.21.71.51.41.41.7-2.00.70.8-1.50.8-1.3-0.9-0.7-1.3-0.5-0.61.20.50.10.0
Bone: endosteal estimation0.51.13.0-1.7-1.1-1.4-1.6-0.8-1.0-0.6-1.7-1.70.0-1.6-0.30.20.40.4-1.2-0.1-0.4-1.2-1.1-0.1
Bone: endosteal perimeter0.71.54.1-2.0-1.3-1.6-0.5-2.0-1.90.5-0.6-0.70.5-0.70.81.2-0.71.70.31.6-1.70.40.71.3
Epididymis fat weight0.10.20.6-0.1-0.1-0.20.6-0.5-0.6-0.20.10.3-0.30.20.00.1-0.70.50.10.6-0.50.70.70.8
Delta time in closed arm before/after self-admin0.60.62.01.11.10.91.40.60.70.50.90.90.10.8-0.20.10.0-0.90.60.00.90.60.80.2
Delta time in open arm before/after self-admin2.32.35.4-2.3-1.6-2.1-2.2-1.4-1.7-1.3-2.3-2.1-0.0-2.2-0.1-0.1-0.01.1-1.6-0.1-1.2-1.5-1.40.1
Diff in mean of infusions in LGA sessions0.30.30.8-0.9-0.6-0.8-0.8-0.5-0.60.3-0.9-0.60.2-0.90.0-0.20.70.3-0.4-0.2-0.4-0.8-0.5-0.1
Delay discount exponential model param0.50.52.0-0.7-0.4-0.3-0.7-0.1-0.2-1.4-0.9-1.0-0.9-1.0-0.7-0.7-0.5-0.4-1.1-0.40.4-0.8-0.8-0.5
Extinction: sum of active levers before priming1.61.74.42.02.11.71.61.91.9-0.71.82.00.21.8-0.10.20.9-0.70.7-0.30.71.00.70.7
Active lever presses in extinction session 61.71.74.71.10.41.01.60.10.41.02.02.10.62.20.90.8-1.10.51.81.2-0.52.11.81.0
Bone: final force0.30.51.2-1.0-0.3-0.7-0.8-0.4-0.2-0.7-1.1-1.0-0.6-1.1-0.5-0.4-0.3-0.4-1.0-0.30.4-0.8-0.8-0.5
Bone: final moment0.20.40.9-0.9-0.2-0.5-0.6-0.3-0.1-0.8-0.9-0.9-0.6-1.0-0.6-0.3-0.2-0.4-1.0-0.20.3-0.7-0.7-0.3
Food consumed during 24 hour testing period3.95.413.7-3.5-3.2-3.6-3.7-2.3-2.80.8-2.9-2.91.8-2.70.91.51.92.0-1.10.6-2.1-1.9-1.70.4
Glucose0.30.52.1-0.50.20.1-0.1-0.20.1-1.4-0.5-0.4-1.3-0.4-0.5-1.1-1.5-0.5-0.9-0.40.5-0.3-0.5-0.6
Heart weight0.71.13.81.81.31.01.11.51.21.21.01.10.71.1-0.20.61.9-0.70.8-0.40.70.40.40.3
Delay discount hyperbolic model param0.60.72.6-0.7-0.4-0.2-0.7-0.1-0.1-1.6-1.0-1.1-1.1-1.1-0.8-0.9-0.7-0.5-1.2-0.50.5-1.0-0.9-0.7
Intermittent access intake day 1-15 change1.12.35.0-1.7-2.2-1.9-1.0-2.0-2.21.6-0.2-0.21.7-0.21.51.80.62.21.01.8-2.10.50.71.4
Intermittent access intake escalation0.71.53.1-1.3-1.7-1.5-0.8-1.5-1.81.2-0.1-0.11.4-0.11.21.50.71.70.81.5-1.70.40.61.2
Intermittent access intake escalation 21.31.53.3-1.2-1.8-1.6-1.0-1.5-1.70.9-0.2-0.31.5-0.21.31.60.61.70.71.5-1.70.40.51.3
Intermitt. access day 1 inactive lever presses0.31.24.1-0.6-0.5-0.10.4-0.9-0.30.31.21.21.01.21.40.9-2.00.81.41.4-0.71.51.41.1
Intermitt. access day 15 inactive lever presses0.30.61.90.40.60.90.40.80.8-1.4-0.1-0.2-1.1-0.1-0.9-1.2-1.0-0.7-0.7-0.70.7-0.2-0.5-0.8
Intermitt. access escalation Index0.40.61.70.80.70.70.80.80.9-0.21.31.30.51.30.40.40.4-0.00.80.2-0.01.00.70.8
Intermittent access day 1 total infusions1.22.04.61.41.91.70.91.82.0-2.10.30.4-1.60.3-1.4-1.7-0.8-1.9-1.0-1.51.9-0.3-0.6-1.1
Intermittent access day 15 total infusions0.20.30.80.80.70.90.70.70.7-0.50.50.6-0.40.5-0.4-0.4-0.3-0.60.1-0.20.60.30.2-0.2
Intermittent access terminal intake (last 3 days)0.30.41.20.90.71.00.70.60.7-0.80.50.5-0.70.5-0.4-0.6-1.1-0.6-0.0-0.20.70.30.2-0.4
Intermittent access total infusions0.60.71.80.91.01.10.61.01.1-1.40.20.3-1.10.2-0.9-1.0-0.9-1.1-0.5-0.71.1-0.1-0.3-0.7
Intermittent access day 1 locomotion1.01.34.91.31.71.50.81.81.9-2.21.00.9-0.81.0-0.7-0.9-0.2-1.3-0.4-0.81.20.4-0.2-0.0
Intermittent access day 15 total locomotion0.61.14.00.91.11.00.31.31.2-2.0-0.2-0.3-1.4-0.2-1.3-1.3-0.4-1.2-1.2-1.21.1-0.6-0.9-0.9
Intermittent access total locomotion1.61.97.01.01.51.30.31.81.6-2.6-0.3-0.3-1.7-0.3-1.6-1.6-0.2-1.6-1.5-1.61.5-0.8-1.2-1.1
Intermittent access standard deviation0.50.92.0-0.6-1.3-0.8-0.1-1.3-1.21.30.30.41.00.31.11.0-0.31.31.01.4-1.30.80.90.9
Left kidney weight0.62.97.4-2.1-2.2-2.4-0.9-2.5-2.72.2-1.2-0.81.6-1.01.12.20.92.10.61.8-2.00.10.71.7
Right kidney weight0.52.36.3-2.2-1.7-2.2-0.7-2.1-2.50.9-1.7-1.50.7-1.70.31.50.71.8-0.31.2-1.9-0.60.21.5
Cocaine induced anxiety0.60.92.31.10.70.91.20.30.70.41.51.50.31.50.60.5-1.1-0.11.20.50.21.31.20.5
Post-drug Anxiety0.20.30.70.80.60.80.80.50.70.30.60.6-0.20.6-0.20.0-0.0-0.50.3-0.10.50.40.3-0.2
Baseline Anxiety0.80.92.8-0.6-0.2-0.5-0.70.1-0.40.3-1.4-1.4-0.6-1.4-1.0-0.51.7-0.3-1.1-0.90.2-1.5-1.2-0.9
Tail length1.97.416.6-3.6-4.0-3.5-2.4-4.1-3.82.7-0.6-0.62.9-0.73.22.8-0.43.61.83.2-3.40.71.21.9
Length with tail0.73.09.6-2.3-2.4-2.3-1.3-3.0-3.11.2-0.9-0.90.8-0.91.51.1-1.42.40.52.0-2.30.30.70.9
Length without tail0.20.72.9-0.10.30.00.1-0.1-0.3-1.4-0.9-0.8-1.7-0.8-1.2-1.2-1.2-0.3-1.3-0.40.2-0.5-0.6-0.6
Times rat made contact with spout0.10.11.00.0-0.2-0.2-0.40.2-0.00.2-0.1-0.00.6-0.00.10.41.00.20.1-0.1-0.2-0.2-0.20.1
Lifetime Intake0.40.51.50.80.81.00.60.70.9-1.10.30.4-0.90.3-0.6-0.8-1.2-0.9-0.3-0.50.90.1-0.1-0.6
Liver weight, left0.40.62.4-1.1-0.8-0.7-0.2-1.3-1.0-0.20.10.10.20.00.90.4-1.51.10.31.1-1.00.70.60.7
Liver weight, right0.61.12.7-1.3-0.9-1.0-0.2-1.6-1.2-0.30.20.10.40.21.21.0-1.61.20.51.6-1.21.01.01.4
Locomotor activity1.32.14.9-0.6-0.0-0.3-1.31.00.8-1.7-1.9-1.7-1.1-1.7-1.5-1.11.4-1.2-2.2-1.71.0-2.1-2.2-1.1
Locomotor testing distance1.22.25.2-0.6-0.1-0.2-1.41.00.9-1.6-1.9-1.8-1.1-1.8-1.6-1.21.3-1.3-2.1-1.81.2-2.2-2.3-1.5
Locomotor testing rearing1.12.26.7-1.8-1.5-1.9-2.0-0.5-1.00.4-2.2-2.10.7-2.2-0.50.82.60.7-1.2-0.3-0.8-1.9-1.60.0
Locomotion in novel chamber1.21.64.1-0.30.6-0.2-0.81.10.6-1.4-1.6-1.4-0.8-1.5-1.3-0.62.0-0.9-1.8-1.50.8-1.9-1.8-0.7
Locomotion in novel chamber post-restriction0.30.41.4-0.9-1.0-0.7-1.2-0.5-0.0-1.00.20.10.60.11.00.7-0.50.60.10.7-0.70.2-0.20.6
Fecal boli incidents, locomotor time 10.91.34.7-1.5-1.7-1.3-0.4-2.2-1.91.6-0.3-0.40.5-0.51.00.8-1.11.40.61.3-1.30.40.90.6
Change in fecal boli incidents, locomotor task1.21.13.80.0-0.4-0.5-0.2-0.2-0.11.31.01.12.01.01.61.71.20.91.51.0-0.90.90.81.3
Time >=10cm from walls, locomotor time 10.40.43.1-0.1-0.7-0.3-0.7-0.1-0.21.6-0.5-0.50.5-0.60.10.11.80.20.1-0.4-0.2-0.8-0.5-0.7
Bouts of movement, locomotor time 10.40.41.30.70.20.50.7-0.00.20.61.01.20.21.00.40.2-0.70.11.00.60.01.00.90.1
Total resting periods, locomotor time 10.80.82.41.00.50.91.20.20.30.71.41.50.21.40.40.4-0.80.11.30.80.11.41.30.3
Rest time, locomotor task time 10.60.72.41.10.71.01.60.20.4-0.11.11.1-0.41.10.10.1-1.1-0.50.80.50.61.21.20.4
Distance moved, locomotor task time 10.71.12.9-0.40.1-0.2-1.20.80.4-1.5-1.2-1.3-0.6-1.1-1.0-1.10.8-0.5-1.6-1.40.4-1.4-1.7-1.0
Vertical activity count, locomotor time 11.12.66.4-2.0-1.8-2.1-2.5-1.3-1.60.9-2.5-2.50.1-2.4-0.4-0.20.90.4-1.4-0.6-0.4-2.1-1.9-1.1
Time >=10cm from walls, locomotor time 20.60.93.80.70.80.90.00.70.9-0.70.0-0.0-1.3-0.1-0.8-1.9-1.2-1.0-0.6-1.21.0-0.4-0.7-1.8
Bouts of movement, locomotor time 20.20.40.80.90.70.70.50.80.80.70.70.70.20.8-0.1-0.10.7-0.60.6-0.10.70.30.2-0.2
Total resting periods, locomotor time 20.10.20.70.60.30.40.20.50.50.80.30.20.20.4-0.1-0.00.8-0.50.4-0.10.60.00.0-0.3
Rest time, locomotor task time 20.20.30.7-0.2-0.8-0.6-0.5-0.6-0.70.8-0.4-0.40.5-0.60.30.70.80.40.10.1-0.3-0.4-0.10.0
Distance moved, locomotor task time 21.72.05.21.21.81.50.71.71.6-2.30.10.0-1.90.0-1.7-2.2-1.0-1.6-1.2-1.51.6-0.4-0.9-1.4
Vertical activity count, locomotor time 20.81.12.7-1.2-0.6-1.2-1.3-0.6-0.9-0.8-1.7-1.5-0.7-1.6-0.9-0.8-0.5-0.3-1.5-0.40.2-1.1-1.3-0.7
Light reinforcement 14.511.028.0-5.0-4.8-5.3-4.3-4.5-4.61.9-3.5-3.42.5-3.41.92.91.33.6-0.72.0-3.7-1.7-1.01.6
Light reinforcement 24.97.519.4-4.4-4.2-4.2-3.7-3.8-3.91.2-3.1-3.11.4-3.01.41.60.12.9-0.81.4-3.0-1.6-1.10.4
Bone: marrow area0.51.23.0-1.7-1.1-1.4-1.6-0.8-1.0-0.5-1.7-1.70.0-1.7-0.30.10.50.3-1.2-0.2-0.4-1.3-1.2-0.2
Bone: maximum diameter0.30.61.8-0.40.1-0.20.9-0.8-0.9-0.00.50.5-0.10.50.30.7-0.91.00.71.2-1.01.11.31.3
Bone: maximum force0.20.41.5-0.7-0.0-0.3-0.5-0.3-0.1-1.2-0.7-0.7-0.9-0.7-0.5-0.6-0.7-0.3-0.9-0.20.3-0.5-0.6-0.4
Bone: maximum moment0.20.31.6-0.60.1-0.3-0.3-0.2-0.0-1.3-0.6-0.6-0.8-0.6-0.6-0.5-0.6-0.2-0.9-0.10.2-0.3-0.5-0.1
Mean time between licks in bursts0.20.62.6-0.20.0-0.30.50.0-0.50.40.40.60.80.40.31.41.11.00.50.8-1.10.70.71.6
Mean num. licks in bursts0.20.41.10.70.40.80.40.30.70.21.00.90.10.90.5-0.4-1.1-0.40.70.00.50.60.4-0.6
Cd content in liver1.51.65.42.22.31.72.32.01.2-0.70.40.5-1.20.4-1.9-0.21.2-0.9-0.5-0.90.70.10.30.6
Co content in liver2.93.410.62.82.42.53.31.81.9-0.82.52.6-0.92.6-0.4-0.2-0.7-0.91.20.20.92.11.91.1
Cu content in liver0.30.41.10.50.80.61.00.70.6-0.8-0.00.4-0.90.3-0.9-0.20.1-0.8-0.4-0.30.80.20.20.4
Fe content in liver1.51.85.70.0-0.70.10.3-1.3-0.30.61.92.10.62.12.00.2-2.40.61.91.5-0.42.11.70.3
K content in liver1.00.94.70.60.91.00.61.01.5-2.20.71.0-1.01.1-0.4-0.9-1.0-1.1-0.3-0.31.00.7-0.0-0.0
Mg content in liver0.90.93.40.40.70.80.80.51.4-1.91.11.5-0.61.40.1-0.4-1.4-0.80.30.40.81.30.60.6
Mn content in liver0.30.31.5-1.0-0.5-0.70.0-0.6-0.6-0.1-0.4-0.20.3-0.4-0.00.90.30.4-0.10.7-0.40.10.31.2
Na content in liver0.20.20.8-0.5-0.6-0.3-0.9-0.4-0.0-0.4-0.1-0.10.00.00.4-0.4-0.8-0.1-0.10.00.2-0.1-0.4-0.6
Rb content in liver0.10.20.5-0.6-0.5-0.5-0.2-0.4-0.30.0-0.10.30.40.30.40.60.10.40.20.5-0.40.30.20.7
Se content in liver1.61.98.5-0.7-0.8-0.30.6-1.8-0.70.01.41.60.11.51.70.3-2.90.71.51.9-0.52.11.90.8
Sr content in liver0.60.51.60.81.10.91.11.01.0-1.30.30.3-0.9-0.1-0.8-0.6-0.2-0.9-0.5-0.50.8-0.10.10.3
Zn content in liver0.91.02.21.21.51.41.41.21.5-0.90.50.5-1.20.5-1.1-0.8-0.2-1.4-0.3-0.71.40.20.2-0.2
Bone: minimum diameter0.91.75.7-2.4-1.7-2.0-1.6-1.8-1.90.5-1.3-1.40.8-1.30.71.00.21.6-0.30.9-1.6-0.5-0.40.6
Time in familiar zone, hab. session 10.90.93.6-0.1-0.5-0.60.1-0.5-1.01.90.20.21.30.20.71.41.31.30.90.8-1.30.40.71.1
Time in novel zone, hab. session 11.11.12.80.80.81.1-0.21.31.7-1.30.2-0.0-0.8-0.0-0.7-1.5-0.4-1.6-0.7-1.31.6-0.6-1.0-1.6
Total zone transitions, hab. session 10.50.72.1-1.0-0.9-1.0-1.5-0.3-0.4-0.2-1.3-1.00.2-1.1-0.3-0.10.8-0.1-0.9-0.40.0-1.2-1.2-0.6
Total locomotion distance, hab. session 10.40.51.6-0.8-0.6-0.6-1.30.10.1-1.0-1.0-0.70.0-1.0-0.3-0.20.5-0.4-1.0-0.50.3-1.1-1.2-0.5
Locomotion velocity, hab. session 10.50.72.0-1.1-0.8-0.9-1.4-0.2-0.1-1.2-1.2-0.9-0.0-1.1-0.3-0.10.4-0.3-1.1-0.30.3-1.1-1.2-0.3
Time in familiar zone, hab. session 20.90.91.9-1.1-1.2-1.4-0.8-1.1-1.30.9-0.4-0.21.2-0.40.91.40.71.30.31.1-1.30.10.31.2
Time in novel zone, hab. session 22.22.34.51.51.91.80.92.11.8-1.6-0.1-0.5-1.8-0.2-2.0-1.90.2-1.8-1.2-2.01.8-0.9-1.0-1.6
Total zone transitions, hab. session 20.60.72.3-1.1-1.2-1.4-1.1-0.6-0.50.2-0.9-0.11.2-0.30.41.31.50.5-0.10.6-0.6-0.3-0.41.1
Total locomotion distance, hab. session 20.40.51.5-1.2-0.8-1.0-1.1-0.4-0.3-1.0-1.2-0.80.1-0.9-0.30.30.6-0.1-0.90.00.0-0.7-0.90.4
Locomotion velocity, hab. session 20.40.61.7-1.3-0.9-1.1-1.2-0.5-0.3-0.9-1.3-0.80.0-0.9-0.30.20.4-0.2-1.00.00.1-0.8-0.90.2
Novel to familiar place preference ratio0.70.81.90.80.70.6-0.21.41.0-0.8-0.4-0.9-0.5-0.6-1.1-0.71.1-0.8-1.0-1.30.7-1.0-1.2-0.9
Novelty place preference1.01.12.40.60.60.5-0.51.40.9-0.9-0.7-1.3-0.6-0.9-1.3-0.91.2-0.8-1.3-1.50.7-1.4-1.5-1.2
Time in novel zone, NPP test1.11.12.70.90.80.9-0.31.61.3-0.9-0.4-1.0-0.6-0.6-1.2-1.10.9-1.1-1.1-1.61.0-1.1-1.4-1.3
Total zone transitions, NPP test0.50.72.2-1.4-1.1-1.5-0.8-1.2-1.1-0.2-1.0-0.20.4-0.40.21.00.40.7-0.30.8-0.8-0.1-0.01.1
Total locomotion distance, NPP test0.10.20.6-0.7-0.4-0.6-0.5-0.2-0.2-0.8-0.6-0.00.2-0.2-0.20.50.5-0.0-0.40.2-0.0-0.1-0.30.6
Locomotion velocity, NPP test0.20.30.9-1.0-0.5-0.8-0.3-0.6-0.7-0.9-0.8-0.2-0.1-0.5-0.30.50.10.2-0.60.4-0.3-0.1-0.10.8
Intraocular pressure1.42.05.62.42.32.22.21.81.8-0.51.51.5-0.91.4-0.9-0.7-0.3-1.40.4-0.81.40.80.7-0.2
Delta distance traveled before/after self-admin0.10.10.5-0.2-0.4-0.5-0.6-0.00.1-0.7-0.1-0.20.4-0.10.20.30.2-0.2-0.20.30.2-0.1-0.30.4
Delta ambulatory time before/after self-admin0.50.61.4-0.9-1.2-1.1-0.9-0.6-0.7-0.1-0.0-0.11.2-0.00.81.20.70.80.31.1-0.90.30.01.1
Parametrial fat weight0.20.61.5-1.2-0.7-1.0-0.5-1.0-1.2-0.5-1.0-1.0-0.4-1.2-0.3-0.0-0.60.6-0.70.4-0.7-0.5-0.30.2
Pavlov. Cond. lever latency0.50.72.9-0.2-0.1-0.4-0.80.50.00.2-1.2-1.50.0-1.1-0.7-0.11.7-0.3-1.0-0.90.2-1.2-1.2-0.4
Pavlov. Cond. magazine entry latency0.50.61.91.10.61.00.90.50.8-0.21.41.3-0.01.10.5-0.3-1.0-0.40.80.20.40.80.8-0.0
Pavlov. Cond. change in total contacts1.01.12.4-0.3-0.4-0.20.5-1.0-0.50.31.31.30.71.11.50.8-1.51.01.41.6-0.91.41.51.1
Pavlov. Cond. index score0.81.02.90.90.61.01.30.20.6-0.51.71.7-0.11.40.7-0.1-1.6-0.01.10.70.11.31.30.5
Pavlov. Cond. latency score0.50.62.10.60.40.71.0-0.10.2-0.41.31.4-0.11.10.60.0-1.40.20.90.7-0.11.11.20.5
Pavlov. Cond. lever contacts0.70.83.40.60.40.80.9-0.10.5-0.51.41.7-0.21.30.7-0.3-1.9-0.11.00.70.21.21.20.2
Pavlov. Cond. magazine entry number1.21.53.6-1.6-1.2-1.7-1.5-0.8-1.40.8-1.9-1.80.6-1.6-0.30.81.80.8-0.9-0.1-0.9-1.2-1.10.2
Pavlov. Cond. intertrial magazine entries1.11.43.80.10.30.11.5-1.0-0.50.61.21.40.01.50.80.8-1.40.81.31.6-0.71.92.01.6
Pavlov. Cond. lever-magazine prob. diff.1.01.23.71.20.91.31.50.40.8-0.91.71.8-0.51.50.4-0.5-1.9-0.30.90.50.31.31.30.2
Pavlov. Cond. response bias1.21.44.31.30.71.31.30.41.1-0.22.12.10.01.80.9-0.3-1.8-0.51.40.60.61.51.40.1
Pavlov. Cond. lever latency0.10.20.80.40.70.50.50.3-0.0-0.1-0.0-0.6-0.9-0.3-0.6-0.7-0.4-0.2-0.4-0.50.2-0.2-0.1-0.4
Pavlov. Cond. magazine entry latency0.10.10.4-0.1-0.1-0.10.2-0.2-0.40.2-0.10.20.30.20.00.50.30.60.20.3-0.60.20.30.4
Pavlov. Cond. change in total contacts0.30.51.80.1-0.30.10.2-0.20.30.60.81.30.91.00.90.7-0.00.21.10.7-0.10.90.80.7
Pavlov. Cond. index score0.20.20.8-0.2-0.4-0.2-0.1-0.30.00.30.30.90.80.70.70.60.10.40.70.5-0.30.50.40.5
Pavlov. Cond. latency score0.20.30.8-0.3-0.5-0.3-0.2-0.4-0.10.30.30.80.90.70.70.7-0.00.60.70.6-0.50.60.50.5
Pavlov. Cond. lever contacts0.10.20.8-0.5-0.7-0.6-0.6-0.3-0.10.3-0.20.40.90.10.40.70.70.20.20.3-0.2-0.0-0.10.3
Pavlov. Cond. magazine entry number0.10.10.40.20.20.1-0.20.30.1-0.0-0.2-0.7-0.2-0.5-0.3-0.30.3-0.3-0.4-0.40.2-0.4-0.5-0.3
Pavlov. Cond. intertrial magazine entries1.01.53.6-1.8-1.7-1.9-1.3-1.6-1.51.3-0.9-1.01.2-1.01.01.40.61.30.21.1-1.4-0.3-0.00.9
Pavlov. Cond. lever-magazine prob. diff.0.20.20.9-0.0-0.3-0.10.0-0.10.10.20.40.90.70.80.60.60.10.30.60.5-0.20.60.40.5
Pavlov. Cond. response bias0.00.10.4-0.2-0.3-0.2-0.2-0.10.2-0.1-0.10.60.40.30.20.30.2-0.10.20.20.10.10.00.2
Time in closed arm before self-admin0.91.22.7-0.9-1.4-0.9-0.9-1.0-0.71.10.60.41.40.61.61.50.61.61.21.2-1.70.70.60.9
Time in closed arm after self-admin0.60.74.20.1-0.1-0.10.5-0.6-0.32.00.90.61.00.81.00.90.50.41.30.6-0.30.81.10.6
Time in open arm before self-admin0.60.62.11.51.21.11.40.90.80.60.70.8-0.30.7-0.7-0.3-0.0-0.90.3-0.21.00.40.5-0.3
Time in open arm after self-admin0.40.52.70.10.40.2-0.10.50.3-1.6-0.6-0.5-0.8-0.6-0.9-0.9-0.5-0.3-1.1-0.70.3-0.6-0.7-0.4
Bone: periosteal estimation0.51.13.8-1.9-1.1-1.6-1.3-1.1-1.3-0.3-1.6-1.50.2-1.6-0.20.60.50.8-0.90.3-0.8-0.9-0.70.4
Bone: periosteal perimeter0.61.13.2-1.4-0.6-1.20.2-1.4-1.60.3-0.3-0.40.4-0.40.41.4-0.11.70.31.5-1.70.60.91.8
Bone: post-yield work0.50.82.4-1.2-0.9-1.0-1.5-0.6-0.70.3-1.3-1.40.1-1.30.0-0.30.30.3-0.8-0.4-0.3-1.2-1.2-0.9
Progressive ratio test 1 active lever presses0.91.12.91.01.21.20.51.11.3-1.70.00.0-1.30.0-1.1-1.4-1.1-1.4-0.9-1.11.4-0.3-0.6-0.9
Progressive ratio test 1 breakpoint1.01.22.91.01.31.30.61.21.3-1.70.00.1-1.40.0-1.1-1.5-1.1-1.4-0.9-1.11.4-0.3-0.5-1.0
Progressive ratio test 1 inactive lever presses0.40.65.40.40.61.00.60.30.7-1.10.50.4-0.80.5-0.3-0.9-2.3-0.7-0.1-0.20.70.40.2-0.6
Progressive ratio test 2 active lever presses0.70.81.61.01.11.10.61.00.9-0.9-0.1-0.1-1.2-0.1-1.1-1.3-0.5-1.2-0.7-1.01.3-0.4-0.5-1.1
Progressive ratio test 2 breakpoint0.80.91.81.11.11.10.61.01.0-0.8-0.1-0.1-1.2-0.1-1.2-1.3-0.5-1.3-0.7-1.01.3-0.4-0.5-1.1
Progressive ratio test 2 inactive lever presses0.81.32.81.41.51.71.11.51.4-1.20.30.3-1.30.3-1.3-1.3-0.7-1.5-0.5-1.11.6-0.1-0.3-1.1
Incentive Sensitization - Responses0.10.10.40.40.30.30.30.2-0.00.4-0.3-0.3-0.4-0.3-0.5-0.50.3-0.4-0.2-0.40.5-0.4-0.2-0.6
Incentive Sensitization - Breakpoint0.10.10.30.30.20.20.20.1-0.10.5-0.3-0.3-0.3-0.3-0.5-0.40.4-0.3-0.2-0.30.4-0.4-0.2-0.5
Sum of active levers in priming session hrs 5-60.50.41.2-0.10.2-0.3-0.70.50.3-0.9-0.8-0.6-0.3-0.7-0.6-0.41.1-0.5-1.0-0.70.4-0.9-1.0-0.2
Progressive ratio0.60.93.3-0.9-0.8-1.1-1.0-0.6-1.10.6-1.8-1.40.2-1.4-0.40.21.80.4-0.8-0.5-0.4-1.3-0.8-0.1
Food seeking constrained by brief footshock1.31.53.5-1.9-1.8-1.6-0.8-1.8-1.90.9-0.6-0.31.0-0.41.11.3-0.11.80.61.3-1.70.40.71.3
Seeking ratio, punishment vs. effort0.50.74.2-0.8-0.8-0.40.0-1.0-0.6-0.00.70.50.20.50.90.5-2.10.90.71.3-0.91.10.90.7
Retroperitoneal fat weight0.20.72.1-1.0-0.3-0.90.1-0.8-1.0-1.4-1.3-0.8-1.0-1.2-0.8-0.1-0.70.5-1.10.4-0.6-0.3-0.10.8
Reaction time number correct0.61.23.21.41.31.41.80.81.0-0.01.71.5-0.11.70.20.1-0.6-0.11.20.30.21.41.40.6
Reaction time mean minus median0.30.72.31.11.21.41.30.70.5-0.80.70.4-1.20.4-0.8-1.1-1.5-0.3-0.1-0.30.40.40.4-0.8
Reaction time mean minus median AUC0.61.43.41.61.71.91.71.10.9-1.50.80.7-1.70.6-1.1-1.4-1.7-0.8-0.3-0.60.80.50.4-0.8
Reaction time num false alarms0.81.14.01.62.01.42.01.51.0-0.50.30.4-1.20.2-1.5-0.40.8-1.1-0.5-0.91.0-0.00.30.2
Reaction time num false alarms AUC0.71.03.81.81.81.42.01.51.10.00.70.8-0.60.7-0.9-0.10.8-0.90.1-0.50.80.40.60.4
Reaction time trials correct on left0.61.23.21.41.31.41.80.81.0-0.01.71.5-0.11.70.20.1-0.6-0.11.20.30.21.41.40.6
Reaction time trials on left0.61.13.41.41.41.51.80.91.0-0.11.61.5-0.21.70.1-0.0-0.6-0.21.00.20.21.31.30.5
Reaction time mean1.82.97.42.42.72.62.12.21.7-1.70.90.7-2.20.7-2.1-2.0-1.1-1.6-0.8-1.51.60.1-0.1-1.4
Reaction time mean AUC1.82.86.92.42.62.52.02.21.7-1.80.90.6-2.20.6-1.9-2.0-1.1-1.6-0.8-1.51.60.1-0.2-1.3
Median of all reaction times2.13.07.72.52.82.62.12.31.9-1.71.00.8-2.10.8-2.0-1.9-0.8-1.8-0.8-1.61.70.1-0.2-1.3
Reaction time omissions1.21.74.61.71.81.51.31.40.6-0.4-0.5-0.5-2.2-0.7-2.1-1.70.2-1.1-1.2-1.61.1-1.0-0.6-1.5
Reaction time false alarm rate0.20.30.80.80.90.50.90.70.5-0.00.00.1-0.4-0.1-0.7-0.00.8-0.6-0.3-0.40.6-0.10.00.2
Reaction time premature initiation rate3.54.810.3-3.2-2.9-3.1-2.1-3.0-2.91.3-0.7-0.82.5-0.72.52.60.32.81.12.5-2.70.50.72.2
Reaction time premature initiations1.73.15.8-2.2-2.0-2.1-1.1-2.2-2.21.20.0-0.12.20.02.22.30.12.41.42.2-2.31.01.12.1
Std. dev. reaction times0.51.02.51.41.51.61.31.00.5-0.80.50.2-1.50.2-1.2-1.4-1.2-0.5-0.4-0.80.50.10.0-1.2
Reaction time trials completed0.61.13.41.41.41.51.80.91.0-0.11.61.5-0.21.70.1-0.0-0.6-0.21.00.20.21.31.30.5
Reaction time trials AUC0.61.13.31.51.41.61.81.01.1-0.21.51.4-0.31.6-0.1-0.1-0.5-0.40.90.00.51.21.10.4
Run reversals in cocaine runway, females2.82.86.30.41.00.60.10.80.7-2.4-1.6-1.4-2.4-1.5-2.2-2.5-1.3-1.9-2.3-2.01.9-1.6-1.6-1.7
Run reversals in cocaine runway, males0.60.63.11.00.30.90.40.80.71.4-0.0-0.1-0.6-0.1-0.8-0.41.7-0.7-0.0-0.80.7-0.6-0.3-1.1
Latency to leave start box in cocaine runway1.41.63.50.40.60.3-0.20.80.3-1.3-1.3-1.4-1.8-1.4-1.9-1.6-0.2-1.1-1.9-1.51.1-1.6-1.5-1.5
Latency to leave start box in cocaine runway, F1.51.73.30.60.90.9-0.11.11.2-1.7-0.7-0.8-1.8-0.9-1.6-1.7-0.7-1.5-1.6-1.71.5-1.3-1.4-1.7
Latency to leave start box in cocaine runway, M0.50.51.6-0.6-0.5-0.9-0.5-0.5-1.2-0.1-1.2-1.3-0.3-1.3-0.6-0.20.30.4-0.9-0.0-0.4-0.8-0.60.0
Std. dev. time between licks in bursts0.81.12.4-1.4-1.1-1.4-0.7-0.9-1.41.1-0.6-0.61.2-0.60.61.51.41.40.30.9-1.4-0.10.21.3
Total sessions with >9 infusions1.72.04.41.81.61.91.71.31.9-1.51.92.0-0.61.9-0.0-0.6-2.1-1.10.7-0.11.11.51.00.2
Short access day 1 total inactive lever presses0.70.99.2-0.30.10.5-0.0-0.20.2-1.6-0.4-0.4-1.3-0.4-0.6-1.3-3.0-0.6-0.8-0.40.6-0.2-0.3-1.1
Short access day 10 total inactive lever presses0.71.63.2-1.3-1.4-1.2-0.7-1.4-1.00.40.60.61.70.61.81.5-0.61.61.11.7-1.71.21.01.7
Short access day 1 total infusions2.53.314.02.21.92.52.31.11.9-1.12.32.3-1.02.3-0.1-0.9-3.7-1.41.0-0.11.51.91.5-0.3
Short access day 10 total infusions0.40.63.10.70.80.90.40.91.2-1.80.60.6-0.70.6-0.4-0.5-1.0-0.8-0.3-0.30.70.4-0.1-0.1
Short access total infusions0.81.03.31.21.11.51.10.91.3-1.31.01.0-0.91.0-0.5-0.8-1.8-1.10.1-0.31.10.70.4-0.4
Short access day 1 locomotion2.22.87.42.22.22.51.91.72.2-1.71.71.7-1.31.7-0.6-1.2-2.7-1.70.3-0.81.71.10.7-0.6
Short access day 10 total locomotion0.61.13.41.31.31.20.81.81.7-1.61.31.3-0.11.3-0.20.01.0-0.70.1-0.30.50.70.10.7
Short access total locomotion1.72.15.11.92.02.11.52.12.3-2.11.81.8-0.71.8-0.5-0.6-0.8-1.30.2-0.51.21.10.40.2
One hour access (0.3 mA shock)0.40.51.00.90.90.80.41.00.8-1.00.00.1-0.80.0-0.9-0.80.1-0.9-0.6-0.70.9-0.3-0.4-0.6
Compulsive drug intake1.41.74.00.4-0.10.20.9-0.30.10.91.92.01.41.91.41.4-0.20.81.91.6-0.71.91.71.6
One hour access (shock baseline)0.81.32.40.70.90.6-0.11.00.6-1.1-1.0-1.0-1.4-1.0-1.6-1.40.5-1.2-1.5-1.51.2-1.3-1.3-1.4
Social response proportion0.70.81.80.30.90.50.30.80.4-0.7-0.9-1.1-1.2-0.9-1.3-1.00.7-1.0-1.2-1.30.9-1.1-0.8-0.7
Social responses0.60.77.7-0.30.2-0.4-0.20.70.10.0-1.0-1.00.1-0.8-0.80.52.8-0.1-0.8-0.7-0.1-1.0-0.80.5
Social time0.70.92.5-0.6-0.8-0.40.2-0.6-0.51.50.70.21.50.51.21.60.71.01.31.3-0.90.81.01.2
Soleus weight0.10.31.00.10.30.0-0.10.50.3-0.0-0.7-0.8-0.3-0.7-0.9-0.21.0-0.5-0.6-0.70.5-0.8-0.6-0.4
Bone: stiffness0.91.53.0-1.3-0.4-0.7-1.4-0.5-0.4-1.2-1.7-1.6-1.2-1.7-0.8-1.3-0.6-0.6-1.7-1.00.6-1.5-1.6-1.5
Tibialis anterior weight0.10.52.40.90.90.91.50.40.2-0.20.80.9-0.50.8-0.40.1-0.30.10.60.3-0.00.81.10.7
Time to tail flick, vehicle, before self-admin0.30.31.4-0.5-0.7-0.7-0.9-0.6-0.61.2-0.6-0.50.3-0.50.3-0.00.90.40.0-0.4-0.4-0.7-0.4-0.5
Time to tail flick, vehicle, after self-admin0.81.03.1-0.9-0.5-1.1-1.0-0.6-1.21.2-1.5-1.80.2-1.5-0.4-0.21.70.0-0.8-0.70.0-1.5-0.9-0.5
Time to tail flick, test, before self-admin1.92.05.01.51.71.81.31.41.3-1.4-0.1-0.2-2.2-0.0-1.8-2.1-1.5-1.5-1.1-1.61.5-0.5-0.5-1.6
Time to tail flick, test, after self-admin0.10.10.6-0.2-0.3-0.2-0.1-0.1-0.50.5-0.4-0.3-0.1-0.3-0.2-0.10.80.5-0.1-0.3-0.5-0.3-0.1-0.1
Delta time to tail flick, vehicle, before/after SA0.10.10.4-0.3-0.1-0.20.3-0.4-0.70.3-0.4-0.6-0.1-0.4-0.2-0.0-0.40.1-0.20.2-0.0-0.10.10.0
Delta time to tail flick, test, before/after SA0.50.51.6-0.2-0.5-0.40.2-0.2-0.41.00.50.51.00.40.61.11.30.80.90.8-0.80.60.71.1
Tibia length0.20.54.6-0.5-0.4-0.0-0.1-0.9-0.2-0.30.60.9-0.30.70.9-0.5-2.10.20.50.6-0.10.80.6-0.4
Ambulatory time before self-admin0.71.02.61.11.21.61.11.11.4-0.30.50.6-1.40.5-0.9-1.0-1.3-1.2-0.2-0.81.30.1-0.0-1.3
Ambulatory time after self-admin0.10.10.50.3-0.10.4-0.00.30.40.00.20.1-0.40.1-0.40.1-0.4-0.2-0.00.10.20.1-0.2-0.7
Bone: tissue strength0.90.92.81.11.21.21.70.50.5-0.91.21.1-1.11.3-0.4-0.5-1.4-0.30.30.20.31.21.00.3
Total heroin consumption0.20.31.20.10.3-0.0-0.10.70.4-0.9-0.6-0.2-0.3-0.4-0.7-0.21.1-0.3-0.8-0.50.2-0.5-0.60.2
Bone: trabecular number3.05.014.2-2.2-3.3-2.4-2.2-2.6-1.93.40.40.53.80.43.52.60.52.32.42.3-2.10.71.01.2
Bone: trabecular spacing2.23.07.52.02.52.01.72.21.5-2.6-0.1-0.1-2.70.0-2.7-2.0-0.3-1.6-1.7-1.81.4-0.5-0.7-1.0
Bone: trabecular thickness0.50.62.7-1.4-1.4-1.1-1.7-0.9-0.40.3-0.6-0.61.0-0.81.00.30.10.30.10.3-0.2-0.5-0.6-0.3
Bone: trabecular tissue density2.43.57.21.51.81.60.31.91.7-1.9-0.9-0.7-2.5-0.9-2.4-2.7-0.2-2.4-2.1-2.52.3-1.5-1.8-2.5
Water consumed over 24 hours0.50.72.7-1.1-1.2-1.2-1.7-0.3-0.40.0-1.0-0.91.0-0.80.30.61.40.2-0.4-0.1-0.2-0.9-1.00.1
Number of responses in last shaping day1.82.05.11.20.91.41.90.20.70.92.32.30.42.30.90.5-1.9-0.21.90.80.32.02.00.6