Hub : Genes

Bpnt2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL mRNA stability Bpnt2 0.07 0.04 2.5e-08 0.06 0.07 0.07 0.06 1.8e-07 3.0e-08 6.5e-08 2.0e-07
2 Brain mRNA stability Bpnt2 0.09 0.05 9.1e-10 0.1 0.1 0.1 0.1 1.3e-09 5.0e-10 1.6e-09 6.6e-10
3 pVTA gene expression Bpnt2 0.22 0.1 0.0e+00 0.28 0.29 0.29 0.29 4.5e-23 8.5e-24 7.2e-24 1.2e-23
4 Eye gene expression Bpnt2 0.48 0.18 2.4e-03 0.07 0.06 0.06 0.07 3.7e-02 5.0e-02 4.7e-02 3.0e-02
5 OFC gene expression Bpnt2 0.61 0.14 1.2e-12 0.32 0.22 0.36 0.18 3.0e-08 6.5e-06 1.7e-09 4.5e-05
6 PL gene expression Bpnt2 0.41 0.12 0.0e+00 0.36 0.38 0.38 0.38 1.5e-41 5.1e-44 1.6e-43 2.6e-44
7 Liver gene expression Bpnt2 0.25 0.1 0.0e+00 0.22 0.23 0.23 0.24 2.3e-24 1.2e-25 3.8e-25 1.3e-26
8 IC gene expression Bpnt2 0.53 0.13 0.0e+00 0.45 0.49 0.47 0.48 8.6e-21 2.5e-23 1.2e-21 7.0e-23
9 NAcc gene expression Bpnt2 0.29 0.09 0.0e+00 0.36 0.37 0.37 0.37 1.7e-57 2.0e-58 6.9e-60 9.2e-60
10 NAcc mRNA stability Bpnt2 0.04 0.03 5.8e-05 0.03 0.03 0.02 0.02 5.2e-05 8.5e-05 3.3e-04 3.2e-04
11 Brain gene expression Bpnt2 0.42 0.1 0.0e+00 0.49 0.49 0.5 0.51 1.2e-51 5.2e-52 1.4e-53 3.2e-54
12 Adipose mRNA stability Bpnt2 0.14 0.07 5.6e-17 0.15 0.15 0.15 0.15 1.5e-16 5.2e-16 3.2e-16 3.0e-16
13 IL gene expression Bpnt2 0.44 0.15 3.1e-09 0.31 0.21 0.26 0.23 3.9e-08 7.3e-06 6.5e-07 2.8e-06
14 BLA gene expression Bpnt2 0.41 0.13 0.0e+00 0.35 0.34 0.34 0.35 1.4e-19 7.9e-19 5.3e-19 3.9e-19
15 Adipose gene expression Bpnt2 0.08 0.05 2.3e-06 0.02 0.05 0.04 0.05 5.0e-03 4.9e-06 2.7e-05 7.0e-06
16 RMTg mRNA stability Bpnt2 0.12 0.08 4.9e-03 0.02 0.05 0.08 0.03 8.7e-02 1.9e-02 4.2e-03 4.7e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.30.43.0-0.4-0.6-0.6-0.40.1-0.60.1-0.4-0.4-0.3-0.6-0.6-0.3-0.6-1.7-1.1
Area under the delay curve1.21.44.41.01.31.41.30.61.2-0.61.01.00.81.31.20.71.32.11.1
BMI with tail0.00.10.8-0.3-0.3-0.2-0.1-0.1-0.20.2-0.2-0.1-0.2-0.0-0.2-0.2-0.1-0.1-0.9
BMI without tail0.00.00.3-0.2-0.10.0-0.0-0.00.10.1-0.00.0-0.10.20.2-0.10.20.3-0.6
Body weight1.25.26.52.62.52.52.32.42.5-2.42.22.42.32.52.52.42.51.00.9
Weight adjusted by age0.40.51.61.20.60.40.30.80.5-0.90.40.50.70.30.20.70.4-1.31.3
Bone surface0.61.11.60.91.01.01.11.31.1-1.21.21.21.31.01.11.21.1-0.50.4
Bone volume0.10.20.60.30.20.20.40.60.3-0.40.40.40.50.20.30.50.3-0.8-0.2
Breakpoint value in progressive ratio session0.80.91.7-0.6-1.0-1.1-1.0-0.9-0.91.1-1.0-1.0-0.7-1.0-1.2-0.8-1.1-1.30.4
Number of licking bursts0.10.10.40.60.30.30.20.40.3-0.30.20.20.30.20.20.40.2-0.50.1
Context. condit. distance diff. score4.95.97.7-2.3-2.6-2.5-2.7-2.3-2.62.4-2.8-2.8-2.7-2.6-2.3-2.4-2.5-1.0-2.2
Locomotion velocity, session 12.62.84.2-2.0-1.8-1.8-1.6-2.1-1.81.8-1.7-1.6-1.7-1.7-1.8-2.0-1.80.3-0.6
Locomotion distance, session 10.70.911.50.10.50.70.5-0.50.20.40.00.2-0.20.50.4-0.40.53.40.5
Locomotion velocity, session 21.01.21.6-1.2-1.1-1.0-0.9-1.2-1.21.1-1.1-1.1-1.1-1.1-1.2-1.3-1.10.2-0.7
Locomotion distance, session 20.40.56.6-0.20.10.20.3-0.6-0.20.5-0.3-0.1-0.40.1-0.2-0.7-0.12.6-0.1
Locomotion velocity, session 30.60.71.4-0.7-0.7-0.8-0.9-1.2-0.71.0-0.8-0.8-0.8-0.7-0.8-1.0-0.80.80.3
Locomotion distance, session 30.10.10.4-0.2-0.2-0.3-0.4-0.6-0.20.4-0.2-0.3-0.2-0.2-0.1-0.3-0.20.60.7
Stereotopy head waving bouts, day 32.53.04.72.21.91.61.51.71.9-1.71.91.71.91.71.61.91.6-0.41.7
Stereotopy head waving duration, day 30.60.71.31.00.90.70.60.70.9-0.70.90.90.90.90.70.90.80.01.2
Locomotion velocity, session 71.51.62.9-1.7-1.5-1.3-1.4-1.4-1.31.3-1.4-1.3-1.4-1.2-1.1-1.1-1.0-0.1-0.8
Locomotion distance, session 70.00.00.0-0.2-0.1-0.0-0.1-0.10.10.10.0-0.0-0.00.10.20.10.20.10.1
Stereotopy head waving bouts, day 70.20.21.2-0.3-0.2-0.1-0.3-0.6-0.30.4-0.4-0.4-0.5-0.2-0.3-0.4-0.11.1-0.0
Stereotopy head waving duration, day 70.30.41.8-0.5-0.3-0.3-0.5-0.9-0.50.6-0.6-0.5-0.8-0.4-0.4-0.6-0.31.4-0.0
Locomotion velocity, session 81.31.52.4-1.3-1.2-1.0-1.0-1.1-1.41.1-1.5-1.4-1.4-1.2-1.3-1.4-1.30.2-1.5
Locomotion distance, session 83.34.76.5-2.3-2.1-1.9-2.1-2.4-2.32.4-2.5-2.4-2.6-2.1-2.0-2.5-2.11.0-1.8
Degree of sensitization distance0.30.30.6-0.7-0.7-0.6-0.6-0.3-0.50.6-0.5-0.6-0.6-0.5-0.4-0.3-0.4-0.7-0.8
Degree of sensitization stereotypy1.01.14.8-1.1-0.7-0.5-0.6-1.3-0.91.1-1.0-0.9-1.3-0.7-0.7-1.2-0.52.2-0.8
Conditioned locomotion0.60.61.0-0.8-0.8-0.8-0.9-1.0-0.80.9-0.9-0.9-0.9-0.8-0.8-1.0-0.80.2-0.3
Cocaine response after cond. corrected0.20.20.7-0.3-0.3-0.3-0.3-0.7-0.40.5-0.5-0.4-0.4-0.3-0.4-0.7-0.50.80.2
Cocaine response after cond. not corrected0.20.20.4-0.5-0.5-0.5-0.3-0.6-0.50.5-0.5-0.4-0.4-0.4-0.5-0.7-0.50.3-0.2
Cocaine response before conditioning0.10.10.7-0.4-0.2-0.10.10.3-0.1-0.10.10.1-0.0-0.1-0.00.10.0-0.7-0.8
Saline control response1.52.03.1-0.8-1.3-1.5-1.8-1.5-1.41.5-1.5-1.6-1.3-1.7-1.6-1.2-1.6-1.1-0.2
Bone: connectivity density0.10.10.70.0-0.00.10.20.50.0-0.40.10.10.20.00.10.20.0-0.8-0.7
Bone: cortical apparent density0.30.41.80.30.30.30.50.80.5-0.90.60.60.70.50.50.80.5-1.30.3
Bone: cortical area1.11.72.41.31.31.31.41.51.4-1.51.41.41.51.31.31.41.3-0.10.6
Bone: cortical porosity0.40.41.0-0.6-0.6-0.6-0.7-1.0-0.60.6-0.7-0.7-0.6-0.6-0.7-0.8-0.60.60.2
Bone: cortical porosity0.30.41.1-0.6-0.5-0.5-0.6-0.9-0.50.5-0.6-0.6-0.6-0.4-0.5-0.7-0.41.00.0
Bone: cortical thickness0.20.30.50.60.60.60.60.70.5-0.70.50.50.50.50.60.60.60.10.1
Bone: cortical thickness0.30.40.90.40.50.80.90.90.6-0.60.60.70.50.60.70.60.60.1-0.4
Bone: cortical tissue density0.30.51.70.30.30.30.50.80.5-1.00.70.70.80.60.60.80.5-1.30.4
Condit. Reinf. active minus inactive responses0.50.51.0-0.9-0.8-0.7-0.7-1.0-0.80.7-0.8-0.7-0.7-0.7-0.5-0.8-0.60.6-0.1
Condit. Reinf. active-inactive response ratio0.60.61.1-1.0-0.9-0.8-0.8-1.0-0.90.8-0.9-0.8-0.8-0.7-0.6-0.9-0.70.4-0.3
Condit. Reinf. active responses0.91.11.6-1.2-1.1-1.1-1.0-1.3-1.21.1-1.2-1.1-1.1-1.1-0.9-1.1-1.00.2-0.4
Condit. Reinf. inactive responses0.50.60.9-0.6-0.8-0.8-0.9-0.7-0.90.8-0.9-0.9-0.8-1.0-0.9-0.8-0.9-0.6-0.5
Incentive salience index mean1.11.32.0-1.4-1.3-1.2-1.1-1.4-1.31.1-1.2-1.1-1.1-1.1-1.0-1.3-1.10.2-0.5
Condit. Reinf. lever presses2.73.94.7-2.1-2.1-2.2-2.0-2.0-2.11.9-2.0-2.0-1.9-2.1-2.1-2.1-2.2-0.9-1.4
Condit. Reinf. active minus inactive responses0.70.91.8-0.9-1.1-1.3-1.3-1.1-0.90.7-0.8-0.9-0.7-1.0-1.0-0.7-1.0-1.30.3
Condit. Reinf. active-inactive response ratio0.20.21.5-0.4-0.4-0.7-0.7-0.6-0.1-0.1-0.1-0.10.0-0.1-0.20.0-0.2-0.81.2
Condit. Reinf. active responses0.60.91.7-0.7-1.0-1.2-1.2-0.9-0.80.7-0.8-0.9-0.7-1.0-1.0-0.6-1.0-1.30.1
Condit. Reinf. inactive responses0.50.60.9-0.6-0.8-0.7-0.7-0.5-0.80.9-0.8-0.9-0.8-0.9-0.9-0.8-0.9-0.7-0.9
Condit. Reinf. lever presses0.20.20.4-0.5-0.5-0.6-0.6-0.4-0.50.3-0.5-0.5-0.4-0.5-0.4-0.4-0.5-0.6-0.3
Condit. Reinf. lever reinforcers received0.81.12.3-0.8-1.1-1.3-1.4-1.0-0.90.8-0.9-1.0-0.8-1.1-1.1-0.7-1.1-1.50.0
Conditioned reinforcement - actives0.81.31.81.31.31.21.31.11.3-1.11.31.21.31.31.01.01.00.60.4
Conditioned reinforcement - inactives0.10.10.7-0.20.10.20.40.20.2-0.20.20.20.10.30.40.10.10.3-0.8
Conditioned locomotion0.10.21.30.10.30.20.2-0.10.40.10.40.30.40.40.00.20.20.61.1
Patch foraging indifference point 0 sec4.48.19.93.03.13.12.82.73.1-3.12.93.02.73.03.12.93.11.61.9
Patch foraging indifference point AUC0.10.10.6-0.4-0.3-0.4-0.2-0.5-0.20.1-0.0-0.00.1-0.1-0.1-0.1-0.10.00.8
Delay disc. indifference point, 0s delay2.42.74.62.11.91.61.51.51.8-1.61.81.61.81.61.41.61.50.31.7
Delay disc. indifference point, 16s delay0.91.02.70.70.91.00.90.41.0-0.50.80.80.61.21.10.71.11.61.5
Delay disc. indifference point, 2s delay0.30.30.80.70.70.80.80.50.6-0.30.50.60.50.60.40.30.50.90.3
Delay disc. indifference point, 24s delay1.01.15.90.30.91.21.10.20.9-0.30.80.80.51.31.30.61.32.40.6
Delay disc. indifference point, 4s delay0.70.73.00.60.81.11.00.40.7-0.40.50.70.40.81.00.41.01.70.5
Delay disc. indifference point, 8s delay1.01.13.61.01.21.31.20.51.0-0.60.80.90.81.31.00.61.11.90.9
Indifference point function ln k0.20.42.2-0.4-0.5-0.3-0.3-0.2-0.60.7-0.5-0.6-0.6-0.6-0.7-0.8-0.7-0.2-1.5
Indifference point function log k0.20.42.2-0.4-0.5-0.3-0.3-0.2-0.60.7-0.5-0.6-0.6-0.6-0.7-0.8-0.7-0.2-1.5
Patch foraging total patch changes 0 sec4.48.310.33.13.13.12.92.93.1-3.22.93.02.83.03.13.03.01.31.8
Patch foraging total patch changes 12 sec1.52.02.61.31.41.51.51.21.4-1.61.31.51.31.51.51.41.51.31.1
Patch foraging total patch changes 18 sec0.91.32.11.31.21.00.91.01.2-1.31.21.21.31.11.21.41.1-0.11.4
Patch foraging total patch changes 24 sec0.91.62.21.41.41.31.31.31.3-1.51.21.31.31.41.41.21.30.60.8
Patch foraging total patch changes 6 sec2.23.34.31.71.92.01.91.81.9-2.11.81.91.72.12.01.92.01.20.9
Patch foraging time to switch 0 sec0.10.20.50.70.50.50.20.20.3-0.40.10.30.30.40.40.40.40.50.7
Patch foraging water rate 0 sec0.10.20.30.30.30.30.50.60.4-0.40.50.40.60.30.30.40.3-0.6-0.1
Patch foraging water rate 12 sec1.43.03.81.91.92.01.91.91.8-1.61.71.71.71.81.81.81.80.70.8
Patch foraging water rate 18 sec2.23.55.72.31.92.01.92.41.9-2.11.81.82.01.61.82.21.8-0.80.4
Patch foraging water rate 24 sec0.30.40.80.80.70.90.90.90.5-0.40.50.50.70.50.50.60.60.1-0.4
Patch foraging water rate 6 sec0.00.00.20.10.10.10.30.20.10.20.20.00.1-0.0-0.2-0.3-0.20.1-0.5
Seeking ratio, delayed vs. immediate footshock0.20.31.8-0.3-0.3-0.1-0.5-0.6-0.20.5-0.6-0.4-0.7-0.00.1-0.10.21.4-0.3
Distance traveled before self-admin0.10.10.20.00.20.20.30.20.3-0.30.40.50.30.40.20.40.50.2-0.2
Distance traveled after self-admin2.12.63.8-1.9-1.8-1.7-1.7-1.9-1.72.0-1.7-1.6-1.6-1.6-1.8-1.6-1.50.1-0.7
Extensor digitorum longus weight3.212.515.43.93.73.63.53.63.7-3.93.63.73.83.63.83.83.60.52.7
Bone: elastic displacement0.10.10.5-0.3-0.3-0.2-0.2-0.1-0.40.4-0.4-0.4-0.4-0.4-0.4-0.4-0.4-0.1-0.7
Bone: elastic work0.20.20.70.20.40.50.60.30.4-0.30.40.50.30.60.50.30.50.90.2
Bone: endosteal estimation0.51.11.61.01.10.90.90.81.2-1.01.31.21.21.11.11.11.10.21.2
Bone: endosteal perimeter0.51.01.70.81.11.11.10.81.0-0.71.11.00.91.11.00.81.11.30.4
Epididymis fat weight0.62.03.2-1.3-1.3-1.2-1.3-1.5-1.41.4-1.6-1.5-1.6-1.2-1.3-1.7-1.40.9-1.8
Delta time in closed arm before/after self-admin0.50.53.80.30.60.80.80.30.5-0.20.40.50.30.60.50.10.52.00.7
Delta time in open arm before/after self-admin0.30.33.50.60.0-0.2-0.40.10.1-0.20.10.00.2-0.0-0.10.5-0.0-1.90.4
Diff in mean of infusions in LGA sessions0.60.71.5-0.7-0.7-0.8-1.1-1.2-0.80.8-1.1-0.9-0.9-0.8-0.7-0.7-0.50.90.2
Delay discount exponential model param1.11.24.9-0.8-1.1-1.3-1.2-0.5-1.10.5-0.8-0.9-0.7-1.3-1.2-0.6-1.3-2.2-1.0
Extinction: sum of active levers before priming0.50.61.30.90.70.80.81.10.7-0.60.80.70.80.70.60.80.7-0.80.2
Active lever presses in extinction session 60.40.44.00.60.30.30.50.90.2-0.40.40.40.60.00.00.40.0-2.0-0.1
Bone: final force1.52.43.11.71.61.51.51.71.6-1.81.61.71.81.51.51.71.5-0.41.0
Bone: final moment1.62.63.31.71.71.61.61.71.7-1.81.71.71.81.61.61.81.6-0.01.2
Food consumed during 24 hour testing period0.10.21.00.40.20.20.30.60.3-0.50.30.30.40.20.10.30.1-1.0-0.4
Glucose0.10.11.10.10.0-0.00.10.50.1-0.30.20.10.10.10.10.20.0-1.0-0.5
Heart weight0.91.32.71.11.11.41.31.71.0-1.30.91.00.91.21.11.21.20.2-1.2
Delay discount hyperbolic model param1.31.45.0-1.0-1.2-1.5-1.4-0.6-1.10.5-0.9-1.0-0.8-1.4-1.2-0.6-1.3-2.2-0.9
Intermittent access intake day 1-15 change0.20.41.30.60.60.50.60.50.6-0.60.70.70.80.60.30.60.50.01.1
Intermittent access intake escalation0.20.40.60.60.60.60.70.60.6-0.60.70.70.80.60.30.60.4-0.10.7
Intermittent access intake escalation 20.20.31.20.60.50.40.40.40.5-0.40.60.40.70.50.20.30.2-0.11.1
Intermitt. access day 1 inactive lever presses0.00.20.50.10.30.40.40.40.4-0.20.40.30.10.50.70.50.50.5-0.2
Intermitt. access day 15 inactive lever presses0.00.11.10.20.10.20.20.40.10.30.1-0.2-0.20.10.20.1-0.0-0.1-1.1
Intermitt. access escalation Index0.10.11.1-0.1-0.00.10.10.10.0-0.40.00.1-0.00.00.50.20.2-0.1-1.1
Intermittent access day 1 total infusions0.81.31.81.21.31.31.31.21.3-1.01.31.21.21.21.11.31.20.5-0.5
Intermittent access day 15 total infusions0.81.21.71.21.21.21.21.11.2-1.01.31.21.21.10.81.11.10.3-0.1
Intermittent access terminal intake (last 3 days)0.50.60.90.91.00.90.90.80.9-0.61.00.80.80.80.60.70.70.4-0.2
Intermittent access total infusions1.72.02.81.61.71.61.61.51.6-1.21.61.51.51.51.11.41.40.7-0.0
Intermittent access day 1 locomotion0.00.00.30.10.20.10.1-0.20.30.20.20.10.10.1-0.1-0.0-0.00.50.3
Intermittent access day 15 total locomotion0.10.10.5-0.1-0.2-0.3-0.3-0.6-0.20.5-0.2-0.2-0.1-0.2-0.5-0.2-0.30.40.7
Intermittent access total locomotion0.10.10.3-0.0-0.0-0.1-0.0-0.3-0.10.4-0.1-0.1-0.1-0.2-0.5-0.3-0.40.40.2
Intermittent access standard deviation0.20.40.9-0.8-0.7-0.7-0.4-0.4-0.60.7-0.4-0.5-0.4-0.6-0.9-0.7-0.9-0.6-0.5
Left kidney weight0.10.41.81.00.70.70.50.70.5-0.70.30.30.30.50.60.60.50.4-1.3
Right kidney weight0.00.11.90.0-0.1-0.0-0.1-0.0-0.30.1-0.3-0.2-0.3-0.1-0.1-0.1-0.10.2-1.4
Cocaine induced anxiety0.20.31.4-0.6-0.6-0.6-0.6-0.3-0.50.3-0.5-0.5-0.5-0.5-0.2-0.1-0.3-0.8-1.2
Post-drug Anxiety1.31.42.31.01.21.21.21.11.1-1.31.21.21.11.21.51.41.50.60.4
Baseline Anxiety3.84.45.32.22.32.32.22.02.1-2.22.02.22.12.12.11.92.21.32.2
Tail length1.03.94.92.22.12.11.92.22.2-1.92.02.01.92.12.22.02.00.41.4
Length with tail2.410.615.03.93.63.53.23.33.5-3.33.33.33.23.33.43.43.31.12.2
Length without tail1.13.76.22.52.22.01.91.92.0-2.11.81.91.91.82.02.01.90.81.2
Times rat made contact with spout0.70.91.5-0.9-0.9-0.7-0.8-0.7-1.00.9-1.0-1.0-1.1-1.0-0.9-1.0-0.90.1-1.2
Lifetime Intake1.51.82.61.61.61.61.61.51.5-1.11.51.41.41.41.01.21.20.7-0.2
Liver weight, left0.60.93.00.30.81.11.00.60.9-0.70.90.90.61.11.20.81.31.70.2
Liver weight, right0.40.71.61.31.01.00.91.10.8-0.80.70.70.80.70.70.80.70.0-0.2
Locomotor activity7.010.914.33.83.63.33.33.33.5-3.53.53.43.53.43.33.43.30.92.6
Locomotor testing distance4.37.811.23.33.02.72.72.72.9-3.02.92.93.12.82.82.92.70.22.8
Locomotor testing rearing3.97.911.43.43.02.72.73.02.8-3.13.02.93.22.72.73.02.6-0.42.4
Locomotion in novel chamber0.30.30.60.70.70.80.80.80.5-0.40.40.40.30.50.80.30.50.80.1
Locomotion in novel chamber post-restriction2.74.48.22.62.31.91.51.52.3-2.22.02.02.12.22.22.32.11.02.9
Fecal boli incidents, locomotor time 10.00.00.30.10.20.20.10.00.20.20.2-0.0-0.10.10.0-0.10.10.50.1
Change in fecal boli incidents, locomotor task0.10.10.20.2-0.1-0.1-0.2-0.1-0.2-0.2-0.2-0.20.0-0.30.20.30.2-0.40.4
Time >=10cm from walls, locomotor time 10.00.00.10.00.10.20.20.20.10.2-0.0-0.0-0.10.2-0.1-0.2-0.10.4-0.3
Bouts of movement, locomotor time 10.00.10.3-0.2-0.2-0.3-0.3-0.1-0.30.0-0.2-0.2-0.0-0.2-0.10.0-0.2-0.5-0.1
Total resting periods, locomotor time 10.00.00.30.1-0.0-0.1-0.10.1-0.1-0.2-0.0-0.10.1-0.10.20.30.1-0.5-0.2
Rest time, locomotor task time 10.20.20.40.50.50.60.30.50.3-0.40.40.20.20.40.60.50.60.2-0.6
Distance moved, locomotor task time 10.00.10.3-0.2-0.1-0.10.1-0.4-0.10.2-0.20.0-0.0-0.1-0.2-0.3-0.30.50.3
Vertical activity count, locomotor time 10.41.11.6-1.2-1.2-1.2-1.0-1.3-1.01.1-1.0-0.9-0.8-1.0-1.1-1.1-1.2-0.20.5
Time >=10cm from walls, locomotor time 21.21.82.8-1.4-1.2-1.0-1.3-1.6-1.31.4-1.4-1.5-1.7-1.1-1.0-1.6-1.21.0-1.4
Bouts of movement, locomotor time 20.10.10.30.20.30.40.40.40.4-0.00.30.20.10.30.20.20.30.2-0.6
Total resting periods, locomotor time 20.10.20.30.40.40.60.50.50.5-0.10.40.30.30.50.30.30.40.3-0.4
Rest time, locomotor task time 20.40.50.80.70.80.90.70.80.5-0.30.70.50.50.70.80.80.90.50.1
Distance moved, locomotor task time 20.10.11.00.30.2-0.10.0-0.20.3-0.50.20.40.50.2-0.0-0.0-0.3-0.11.0
Vertical activity count, locomotor time 20.00.10.6-0.2-0.1-0.2-0.1-0.40.2-0.00.10.10.10.0-0.1-0.2-0.20.10.8
Light reinforcement 11.23.03.71.91.81.81.81.81.8-1.91.61.71.91.81.81.81.80.41.4
Light reinforcement 20.71.12.00.90.91.01.11.21.0-1.11.01.21.41.01.01.21.1-0.71.0
Bone: marrow area0.61.31.91.11.21.01.11.01.3-1.21.41.31.31.21.21.21.20.31.3
Bone: maximum diameter1.52.73.61.61.81.81.91.81.7-1.71.81.81.71.71.71.61.70.60.7
Bone: maximum force0.81.41.91.21.21.21.21.41.3-1.41.31.31.31.21.21.31.2-0.20.4
Bone: maximum moment0.91.62.11.31.31.31.31.31.4-1.41.41.41.31.31.31.31.30.30.7
Mean time between licks in bursts1.43.34.62.02.02.21.91.61.9-1.51.81.81.61.92.01.72.01.81.2
Mean num. licks in bursts0.50.81.5-1.2-1.0-0.8-0.8-1.0-1.00.9-0.9-0.9-1.0-0.9-0.8-1.1-0.80.4-0.8
Cd content in liver0.80.92.6-1.6-1.1-0.9-0.7-1.0-0.91.0-0.8-0.7-1.0-0.8-0.9-1.0-0.80.5-0.8
Co content in liver0.30.41.10.60.60.60.50.20.6-0.30.50.50.50.60.60.50.61.00.8
Cu content in liver0.91.02.81.21.10.90.70.51.1-1.00.90.91.01.10.91.11.10.81.7
Fe content in liver0.10.10.7-0.3-0.1-0.1-0.0-0.2-0.10.1-0.2-0.1-0.3-0.1-0.0-0.2-0.10.8-0.4
K content in liver0.60.55.50.80.1-0.1-0.20.30.1-0.50.20.10.50.0-0.10.50.0-2.41.2
Mg content in liver0.30.32.60.60.2-0.0-0.10.20.2-0.40.20.20.50.1-0.00.40.1-1.61.2
Mn content in liver0.20.21.50.70.20.10.00.30.2-0.30.10.10.30.00.10.40.1-1.20.5
Na content in liver0.10.10.50.0-0.2-0.2-0.3-0.1-0.40.1-0.3-0.4-0.3-0.4-0.3-0.2-0.3-0.7-0.4
Rb content in liver5.76.68.93.02.82.62.52.42.7-2.72.72.72.92.62.52.62.50.62.4
Se content in liver0.70.81.31.00.80.80.71.00.9-1.10.90.80.90.80.91.10.9-0.90.5
Sr content in liver1.51.31.7-1.1-1.1-1.1-1.2-1.3-1.21.3-1.2-1.3-1.3-1.2-1.1-1.2-1.10.3-0.7
Zn content in liver0.20.21.80.40.1-0.1-0.2-0.10.3-0.30.20.20.40.10.00.30.1-1.01.3
Bone: minimum diameter0.50.91.31.10.90.70.70.91.0-1.01.01.01.10.90.91.20.9-0.61.0
Time in familiar zone, hab. session 11.61.62.5-1.3-1.3-1.1-1.3-1.2-1.21.6-1.4-1.4-1.5-1.2-1.2-1.2-1.10.1-1.3
Time in novel zone, hab. session 10.80.81.30.90.80.70.80.80.8-1.20.91.01.10.80.80.90.7-0.31.0
Total zone transitions, hab. session 12.23.17.51.51.92.01.91.21.8-1.31.61.71.41.91.91.41.92.71.0
Total locomotion distance, hab. session 13.75.26.62.22.42.62.52.32.4-2.32.32.42.12.52.52.32.51.61.1
Locomotion velocity, hab. session 14.15.76.82.42.62.62.62.42.6-2.52.52.62.42.62.52.42.61.31.5
Time in familiar zone, hab. session 20.20.20.9-0.2-0.4-0.4-0.5-0.1-0.40.5-0.4-0.5-0.4-0.6-0.6-0.2-0.5-1.0-0.6
Time in novel zone, hab. session 21.21.24.10.51.01.11.20.51.0-1.10.91.10.81.31.30.71.22.00.8
Total zone transitions, hab. session 21.41.813.10.51.21.61.60.60.9-0.60.81.00.41.31.30.41.33.6-0.2
Total locomotion distance, hab. session 22.73.611.21.21.92.32.31.51.7-1.51.51.81.22.12.11.42.23.40.0
Locomotion velocity, hab. session 22.33.19.41.01.72.22.21.51.6-1.41.51.71.21.92.01.32.03.1-0.1
Novel to familiar place preference ratio0.60.61.4-1.0-0.8-0.8-0.9-1.2-0.71.0-0.8-0.7-0.9-0.6-0.4-0.8-0.50.8-0.1
Novelty place preference0.60.61.3-1.1-0.8-0.8-0.8-1.1-0.71.0-0.7-0.7-0.9-0.6-0.4-0.8-0.50.7-0.2
Time in novel zone, NPP test0.70.71.5-1.2-0.9-0.9-0.9-1.2-0.81.0-0.8-0.8-1.0-0.7-0.5-0.8-0.60.7-0.2
Total zone transitions, NPP test0.71.09.10.50.91.21.20.30.7-0.30.50.70.40.90.80.10.83.00.1
Total locomotion distance, NPP test2.63.65.21.72.02.22.21.61.9-1.61.82.01.72.12.01.62.12.30.9
Locomotion velocity, NPP test2.02.84.51.51.82.02.01.51.7-1.41.61.71.51.81.81.31.82.10.7
Intraocular pressure0.50.71.20.20.70.91.10.80.8-0.80.81.00.70.91.00.81.00.8-0.0
Delta distance traveled before/after self-admin4.95.26.8-2.4-2.4-2.3-2.4-2.5-2.42.6-2.4-2.5-2.4-2.4-2.4-2.5-2.4-0.1-1.2
Delta ambulatory time before/after self-admin2.43.04.1-1.7-1.8-1.7-1.7-1.9-1.92.0-1.9-1.9-1.8-1.8-1.9-1.9-1.70.2-1.2
Parametrial fat weight0.20.50.7-0.5-0.7-0.7-0.8-0.7-0.80.6-0.9-0.8-0.7-0.8-0.8-0.7-0.8-0.6-0.3
Pavlov. Cond. lever latency1.41.72.21.41.31.31.31.41.4-1.31.51.41.41.31.31.51.3-0.11.3
Pavlov. Cond. magazine entry latency0.30.41.00.70.70.60.50.20.6-0.30.50.50.50.70.50.40.61.00.9
Pavlov. Cond. change in total contacts0.00.00.10.20.10.1-0.1-0.0-0.00.2-0.1-0.1-0.1-0.00.0-0.00.00.3-0.1
Pavlov. Cond. index score0.10.10.6-0.1-0.1-0.1-0.2-0.4-0.20.4-0.3-0.3-0.3-0.2-0.2-0.4-0.20.8-0.0
Pavlov. Cond. latency score0.00.10.6-0.0-0.00.0-0.0-0.3-0.10.2-0.2-0.1-0.2-0.0-0.1-0.3-0.10.8-0.1
Pavlov. Cond. lever contacts2.53.03.8-1.7-1.8-1.7-1.8-1.8-1.91.8-2.0-1.9-1.9-1.8-1.8-1.9-1.8-0.0-1.5
Pavlov. Cond. magazine entry number0.40.50.9-0.8-0.8-0.7-0.6-0.3-0.70.4-0.6-0.7-0.7-0.7-0.6-0.5-0.7-1.0-1.0
Pavlov. Cond. intertrial magazine entries0.00.00.10.0-0.10.0-0.10.0-0.1-0.2-0.1-0.10.0-0.10.20.20.1-0.30.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.6-0.2-0.2-0.2-0.3-0.5-0.30.5-0.4-0.4-0.4-0.2-0.3-0.5-0.30.8-0.2
Pavlov. Cond. response bias0.40.50.9-0.5-0.6-0.6-0.7-0.9-0.70.9-0.8-0.8-0.7-0.6-0.7-0.8-0.70.6-0.1
Pavlov. Cond. lever latency0.00.10.20.40.30.30.20.30.2-0.20.10.10.10.20.20.20.20.20.0
Pavlov. Cond. magazine entry latency1.51.82.61.01.21.11.31.41.4-1.61.61.61.61.41.41.51.4-0.51.2
Pavlov. Cond. change in total contacts0.10.20.90.30.40.40.4-0.00.4-0.40.40.40.40.50.40.20.40.90.8
Pavlov. Cond. index score0.20.30.40.30.40.50.50.50.6-0.60.60.70.60.50.60.60.5-0.10.5
Pavlov. Cond. latency score0.30.40.60.40.60.60.70.60.7-0.70.80.80.70.70.70.60.70.10.4
Pavlov. Cond. lever contacts0.10.10.3-0.5-0.4-0.4-0.3-0.4-0.30.3-0.3-0.3-0.3-0.3-0.3-0.4-0.3-0.1-0.1
Pavlov. Cond. magazine entry number0.60.71.0-0.6-0.7-0.6-0.7-0.8-0.91.0-1.0-1.0-1.0-0.8-0.8-1.0-0.70.6-1.0
Pavlov. Cond. intertrial magazine entries4.87.38.8-2.7-2.8-2.8-2.9-2.9-2.82.8-2.9-2.9-3.0-2.8-2.8-2.8-2.8-0.4-1.8
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.10.30.30.30.30.4-0.50.50.50.50.40.40.40.4-0.20.3
Pavlov. Cond. response bias0.10.10.2-0.00.20.10.20.10.3-0.40.40.40.40.30.30.30.3-0.10.5
Time in closed arm before self-admin0.20.21.8-0.2-0.4-0.5-0.5-0.4-0.20.3-0.1-0.20.1-0.3-0.60.1-0.2-1.30.8
Time in closed arm after self-admin1.01.11.6-1.2-1.1-1.0-1.0-1.1-1.11.2-1.0-1.0-0.9-1.1-1.3-1.1-1.1-0.2-0.2
Time in open arm before self-admin0.20.20.50.60.50.60.50.50.3-0.40.10.20.10.30.50.00.10.7-0.7
Time in open arm after self-admin0.20.20.70.80.60.40.30.40.6-0.40.40.30.30.60.50.50.40.20.4
Bone: periosteal estimation1.22.53.21.51.61.61.61.61.7-1.71.81.71.81.61.61.71.70.31.3
Bone: periosteal perimeter0.00.10.30.10.30.30.40.20.3-0.20.40.30.30.30.30.10.30.5-0.0
Bone: post-yield work1.72.63.61.61.71.71.71.71.7-1.91.81.71.71.71.61.61.60.30.8
Progressive ratio test 1 active lever presses0.40.51.21.11.00.80.80.60.9-0.60.90.80.90.70.40.40.40.40.0
Progressive ratio test 1 breakpoint0.60.81.71.31.20.91.00.81.1-0.81.11.01.10.80.50.60.50.40.2
Progressive ratio test 1 inactive lever presses0.40.61.10.70.80.91.01.00.8-0.70.80.80.70.70.70.60.60.2-0.8
Progressive ratio test 2 active lever presses0.10.11.60.10.0-0.00.10.0-0.10.1-0.2-0.1-0.0-0.2-0.5-0.4-0.50.0-1.3
Progressive ratio test 2 breakpoint0.10.21.80.20.00.00.10.1-0.10.1-0.2-0.1-0.0-0.2-0.5-0.4-0.5-0.0-1.3
Progressive ratio test 2 inactive lever presses0.50.91.41.11.21.11.10.81.0-0.70.90.90.91.10.90.70.71.2-0.2
Incentive Sensitization - Responses0.10.10.6-0.3-0.3-0.3-0.2-0.2-0.40.2-0.4-0.3-0.2-0.3-0.4-0.4-0.6-0.2-0.8
Incentive Sensitization - Breakpoint0.20.20.8-0.3-0.4-0.4-0.3-0.3-0.50.3-0.6-0.4-0.4-0.4-0.5-0.5-0.7-0.2-0.9
Sum of active levers in priming session hrs 5-60.20.21.6-0.0-0.00.00.30.50.2-0.30.30.30.30.10.10.30.1-1.30.3
Progressive ratio1.11.77.3-1.3-1.2-0.9-1.1-1.0-1.31.3-1.4-1.3-1.6-1.2-0.9-1.2-0.90.3-2.7
Food seeking constrained by brief footshock2.53.05.1-2.0-1.6-1.4-1.2-1.9-1.71.8-1.8-1.6-2.0-1.4-1.6-2.3-1.71.3-2.1
Seeking ratio, punishment vs. effort0.50.83.30.70.90.70.90.50.9-0.81.01.01.01.00.50.50.50.61.8
Retroperitoneal fat weight0.10.40.80.80.50.60.50.90.5-0.80.40.50.50.70.60.70.5-0.7-0.2
Reaction time number correct1.22.43.61.91.81.81.81.91.5-1.61.51.51.51.41.51.61.60.40.2
Reaction time mean minus median1.43.45.4-1.5-2.0-2.1-2.3-2.1-1.91.7-2.0-2.0-1.8-2.0-1.8-1.6-1.9-1.3-0.2
Reaction time mean minus median AUC0.41.01.8-0.9-1.1-1.2-1.3-1.2-1.00.9-1.1-1.1-0.9-1.0-0.8-0.7-0.9-0.70.3
Reaction time num false alarms0.30.50.9-0.7-0.6-0.5-0.7-0.9-0.60.9-0.7-0.7-0.9-0.6-0.7-0.9-0.50.8-0.3
Reaction time num false alarms AUC0.40.60.9-0.9-0.8-0.8-0.8-1.0-0.70.9-0.7-0.7-0.9-0.7-0.8-0.9-0.70.3-0.3
Reaction time trials correct on left1.22.43.61.91.81.81.81.91.5-1.61.51.51.51.41.51.61.60.40.2
Reaction time trials on left1.22.23.51.91.71.81.71.81.4-1.51.51.41.51.41.51.51.50.30.2
Reaction time mean2.84.57.0-2.2-2.2-2.2-2.5-2.6-2.22.3-2.4-2.3-2.4-2.0-1.8-2.1-2.00.2-0.6
Reaction time mean AUC3.04.77.3-2.2-2.3-2.3-2.6-2.7-2.22.4-2.5-2.4-2.5-2.1-1.9-2.1-2.10.2-0.6
Median of all reaction times2.33.25.2-2.0-1.9-1.8-2.0-2.3-1.82.0-2.1-1.9-2.1-1.6-1.4-1.8-1.60.7-0.6
Reaction time omissions0.50.71.5-0.8-0.9-0.9-1.1-1.2-0.90.8-1.0-0.9-0.9-0.8-0.7-0.7-0.70.10.1
Reaction time false alarm rate1.41.93.1-1.8-1.5-1.4-1.5-1.7-1.31.6-1.3-1.3-1.6-1.3-1.4-1.6-1.30.4-0.6
Reaction time premature initiation rate0.81.24.5-0.5-1.0-1.3-1.4-0.9-1.00.7-1.0-1.1-0.8-1.1-1.1-0.6-1.1-2.10.1
Reaction time premature initiations0.20.43.70.2-0.3-0.5-0.7-0.1-0.40.0-0.4-0.5-0.1-0.6-0.50.0-0.4-1.90.1
Std. dev. reaction times3.15.88.2-2.4-2.6-2.7-2.9-2.8-2.52.4-2.7-2.6-2.5-2.5-2.3-2.3-2.5-1.0-0.8
Reaction time trials completed1.22.23.51.91.71.81.71.81.4-1.51.51.41.51.41.51.51.50.30.2
Reaction time trials AUC0.91.72.81.71.51.61.51.61.3-1.31.31.21.31.21.31.41.30.40.2
Run reversals in cocaine runway, females0.20.20.5-0.1-0.2-0.3-0.3-0.6-0.40.5-0.5-0.4-0.3-0.4-0.6-0.7-0.60.60.6
Run reversals in cocaine runway, males0.50.52.1-0.0-0.5-0.7-0.8-0.2-0.50.4-0.4-0.5-0.2-0.7-0.8-0.3-0.8-1.41.2
Latency to leave start box in cocaine runway0.30.30.70.60.50.40.40.90.5-0.50.60.30.60.30.60.70.4-0.8-0.6
Latency to leave start box in cocaine runway, F0.20.30.80.50.50.30.40.70.5-0.50.70.40.50.30.30.50.2-0.9-0.2
Latency to leave start box in cocaine runway, M0.20.11.00.0-0.2-0.3-0.3-0.1-0.30.2-0.4-0.5-0.3-0.4-0.10.0-0.3-0.5-1.0
Std. dev. time between licks in bursts0.60.81.51.21.11.01.01.01.0-0.80.90.80.90.90.91.00.90.20.5
Total sessions with >9 infusions0.10.10.80.20.10.10.1-0.00.00.3-0.0-0.1-0.1-0.2-0.4-0.3-0.20.2-0.9
Short access day 1 total inactive lever presses0.10.10.30.20.30.40.40.40.3-0.30.30.30.20.30.50.30.30.4-0.5
Short access day 10 total inactive lever presses0.30.81.50.80.90.90.91.00.9-0.80.90.80.70.91.21.11.10.40.1
Short access day 1 total infusions0.00.00.10.40.30.30.20.10.2-0.10.10.10.10.10.00.1-0.00.2-0.1
Short access day 10 total infusions0.10.10.80.40.40.30.30.20.40.00.40.20.20.2-0.20.00.00.2-0.9
Short access total infusions0.50.61.01.00.91.01.00.90.8-0.50.70.70.70.60.40.60.60.4-0.9
Short access day 1 locomotion0.50.71.1-0.7-0.8-0.9-1.0-1.0-0.80.9-0.9-0.9-0.9-1.0-0.7-0.7-0.7-0.10.5
Short access day 10 total locomotion0.00.00.50.10.10.10.0-0.10.30.10.10.10.10.1-0.1-0.0-0.10.20.7
Short access total locomotion0.10.10.30.00.0-0.1-0.1-0.30.00.50.0-0.1-0.0-0.1-0.4-0.3-0.30.30.5
One hour access (0.3 mA shock)1.11.31.81.11.21.11.21.11.3-1.31.31.31.31.31.01.01.00.30.6
Compulsive drug intake0.80.91.5-1.2-1.1-1.0-1.0-0.8-1.00.8-1.0-0.9-1.1-0.9-0.8-1.0-0.8-0.7-1.1
One hour access (shock baseline)0.20.20.40.50.60.50.60.50.6-0.40.70.60.60.50.40.50.40.20.2
Social response proportion3.43.85.11.81.92.01.91.92.0-2.11.92.11.92.12.32.22.20.71.6
Social responses5.87.59.53.13.02.82.62.82.8-2.82.82.82.82.92.93.02.90.72.2
Social time2.33.24.41.41.71.81.91.71.8-2.01.81.91.82.02.11.82.01.01.4
Soleus weight7.622.527.65.25.15.05.15.05.0-5.35.05.15.14.94.94.84.71.22.9
Bone: stiffness0.81.22.11.11.11.21.21.41.2-1.31.21.11.11.11.11.21.1-0.20.1
Tibialis anterior weight1.03.24.41.81.91.91.91.81.9-2.11.81.91.81.92.01.71.80.81.0
Time to tail flick, vehicle, before self-admin0.60.61.61.00.71.00.81.30.6-0.90.40.50.50.71.01.00.9-0.2-0.4
Time to tail flick, vehicle, after self-admin0.71.03.6-1.0-0.9-0.7-0.7-0.8-1.01.0-1.0-1.0-1.2-0.8-0.7-0.9-0.70.7-1.9
Time to tail flick, test, before self-admin3.73.85.2-1.6-2.1-2.2-2.3-1.8-2.01.4-2.0-2.0-1.9-2.2-2.0-1.7-2.1-2.3-1.2
Time to tail flick, test, after self-admin0.00.00.1-0.1-0.1-0.0-0.2-0.1-0.2-0.2-0.1-0.1-0.2-0.10.00.00.1-0.0-0.4
Delta time to tail flick, vehicle, before/after SA2.72.63.6-1.9-1.6-1.6-1.6-1.8-1.61.8-1.4-1.6-1.7-1.6-1.7-1.8-1.70.1-1.6
Delta time to tail flick, test, before/after SA2.02.15.11.01.51.61.51.11.4-1.21.51.41.21.61.71.21.62.31.0
Tibia length0.51.32.1-1.3-1.2-1.3-1.3-1.5-1.21.1-1.2-1.2-1.2-1.1-1.2-1.1-1.1-0.1-0.1
Ambulatory time before self-admin0.00.00.1-0.10.0-0.00.20.20.2-0.10.30.40.20.2-0.10.20.2-0.2-0.0
Ambulatory time after self-admin1.41.73.4-1.3-1.3-1.3-1.2-1.5-1.31.8-1.4-1.3-1.2-1.2-1.6-1.3-1.20.4-0.6
Bone: tissue strength0.10.10.4-0.5-0.4-0.4-0.5-0.7-0.30.4-0.3-0.3-0.3-0.3-0.3-0.3-0.20.30.3
Total heroin consumption0.81.01.8-1.2-1.2-1.0-0.9-1.0-1.11.3-1.2-1.0-0.9-0.9-1.0-0.9-0.9-0.1-0.4
Bone: trabecular number0.10.11.50.1-0.0-0.00.10.50.0-0.30.10.10.3-0.00.00.3-0.0-1.2-0.5
Bone: trabecular spacing0.20.31.7-0.4-0.2-0.1-0.1-0.5-0.40.7-0.5-0.4-0.6-0.3-0.2-0.6-0.31.3-0.4
Bone: trabecular thickness0.40.60.8-0.9-0.8-0.9-0.9-0.9-0.80.7-0.8-0.8-0.8-0.7-0.6-0.8-0.7-0.2-0.6
Bone: trabecular tissue density0.10.11.30.3-0.1-0.1-0.20.3-0.2-0.3-0.1-0.2-0.0-0.3-0.20.1-0.2-1.2-0.6
Water consumed over 24 hours0.00.10.3-0.1-0.2-0.1-0.10.1-0.20.1-0.2-0.2-0.2-0.3-0.2-0.1-0.2-0.5-0.5
Number of responses in last shaping day0.20.20.90.60.50.30.30.20.6-0.20.50.40.30.3-0.00.20.10.21.0