Hub : Genes

Bivm

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Bivm 0.04 0.03 3.7e-03 0.01 0.02 0.02 0.01 7.3e-02 1.4e-02 1.4e-02 6.1e-02
2 Adipose intron excision ratio chr9_53776541_53777310 0.06 0.05 7.3e-07 0.04 0.03 0.04 0.04 1.0e-05 1.6e-04 3.5e-05 2.7e-05
3 BLA gene expression Bivm 0.06 0.06 1.8e-03 0.06 0.04 0.05 0.05 5.6e-04 3.8e-03 1.6e-03 1.2e-03
4 IC gene expression Bivm 0.07 0.06 8.3e-03 0.05 0.03 0.04 0.04 3.8e-03 2.2e-02 9.5e-03 1.2e-02
5 Adipose alternative polyA XM_006244874.5 0.14 0.09 0.0e+00 0.11 0.1 0.1 0.1 7.1e-12 1.2e-10 2.9e-11 1.2e-11
6 Adipose alternative polyA XM_039082902.2 0.13 0.09 5.6e-17 0.1 0.09 0.1 0.1 1.2e-11 1.7e-10 9.7e-11 1.5e-11
7 Adipose intron excision ratio chr9_53777415_53781305 0.05 0.04 8.4e-06 0.03 0.02 0.03 0.03 3.5e-04 1.8e-03 5.8e-04 7.7e-04
8 Liver intron excision ratio chr9_53776541_53781305 0.06 0.05 4.7e-07 0.04 0.04 0.04 0.04 1.0e-05 4.1e-05 1.1e-05 1.3e-05
9 Liver intron excision ratio chr9_53777415_53781305 0.03 0.02 2.8e-03 0 -0 -0 -0 1.2e-01 6.9e-01 7.1e-01 8.7e-01
10 Adipose isoform ratio XR_005488841.2 0.08 0.07 5.0e-08 0.04 0.04 0.02 0.03 2.2e-05 7.2e-05 1.1e-03 1.0e-04
11 Adipose intron excision ratio chr9_53776541_53781305 0.13 0.11 2.1e-13 0.07 0.08 0.07 0.07 2.0e-08 8.1e-09 5.4e-08 9.5e-09
12 Liver gene expression Bivm 0.2 0.11 0.0e+00 0.14 0.16 0.16 0.15 1.0e-15 1.5e-17 2.9e-17 8.7e-17
13 Adipose gene expression Bivm 0.04 0.04 1.3e-04 0 0.01 0.01 0 1.2e-01 1.4e-02 4.1e-02 1.1e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density5.19.410.12.8-2.93.03.03.2-3.2-3.23.2-3.1-3.0-3.1-3.1-3.1
Area under the delay curve0.30.41.1-0.30.2-0.4-0.4-0.60.60.6-0.60.60.80.81.11.0
BMI with tail1.65.67.9-2.72.8-2.5-2.4-2.32.32.3-2.32.32.62.32.02.0
BMI without tail0.10.40.8-0.40.8-0.7-0.7-0.50.50.5-0.50.50.90.60.60.6
Body weight0.10.40.6-0.60.5-0.5-0.4-0.60.60.6-0.60.70.70.70.80.8
Weight adjusted by age0.10.41.2-1.10.6-0.7-0.7-0.30.30.3-0.30.61.00.70.30.3
Bone surface0.30.61.10.6-0.50.60.60.8-0.8-0.80.8-0.8-0.6-0.8-1.1-1.1
Bone volume2.04.04.81.8-1.81.81.82.1-2.1-2.12.1-2.0-1.9-2.1-2.2-2.2
Breakpoint value in progressive ratio session0.40.71.01.0-0.80.80.80.9-0.9-0.90.9-0.8-1.0-0.9-0.7-0.7
Number of licking bursts0.10.20.30.4-0.50.50.50.4-0.4-0.40.4-0.4-0.6-0.5-0.5-0.5
Context. condit. distance diff. score1.31.52.51.6-1.61.51.51.0-1.0-1.01.0-1.2-1.3-1.2-0.8-0.8
Locomotion velocity, session 10.10.10.20.40.2-0.2-0.3-0.10.10.1-0.10.1-0.10.10.40.5
Locomotion distance, session 11.41.72.6-0.81.6-1.6-1.6-1.31.31.3-1.31.11.11.21.41.4
Locomotion velocity, session 24.04.86.0-2.42.4-2.4-2.4-2.12.12.1-2.12.22.22.22.02.0
Locomotion distance, session 24.05.66.3-2.52.4-2.5-2.5-2.42.42.4-2.42.32.32.32.22.2
Locomotion velocity, session 30.10.10.20.4-0.30.40.30.2-0.2-0.20.2-0.4-0.3-0.3-0.3-0.2
Locomotion distance, session 30.10.10.20.4-0.40.40.50.3-0.3-0.30.3-0.4-0.4-0.4-0.3-0.3
Stereotopy head waving bouts, day 30.30.30.60.7-0.40.50.50.6-0.6-0.60.6-0.6-0.5-0.6-0.6-0.5
Stereotopy head waving duration, day 30.20.30.90.9-0.30.30.30.6-0.6-0.60.6-0.6-0.3-0.4-0.2-0.2
Locomotion velocity, session 70.30.30.7-0.80.7-0.6-0.6-0.60.60.6-0.60.50.50.50.30.3
Locomotion distance, session 70.60.81.2-1.11.0-0.9-0.9-0.80.80.8-0.80.90.90.90.80.8
Stereotopy head waving bouts, day 70.20.20.50.6-0.50.60.70.4-0.4-0.40.4-0.5-0.4-0.4-0.3-0.3
Stereotopy head waving duration, day 70.20.30.60.8-0.60.70.70.4-0.4-0.40.4-0.6-0.4-0.5-0.3-0.3
Locomotion velocity, session 80.00.00.0-0.0-0.10.1-0.1-0.10.10.1-0.1-0.0-0.2-0.1-0.1-0.1
Locomotion distance, session 80.60.81.1-0.90.7-0.8-0.9-1.11.11.1-1.10.80.80.90.90.9
Degree of sensitization distance1.21.31.5-1.21.1-1.2-1.1-1.01.01.0-1.01.21.11.21.11.1
Degree of sensitization stereotypy0.00.10.20.2-0.30.40.50.1-0.1-0.10.1-0.2-0.2-0.2-0.1-0.1
Conditioned locomotion0.10.10.40.10.5-0.6-0.6-0.20.20.2-0.20.20.20.30.50.5
Cocaine response after cond. corrected0.71.01.6-0.81.0-0.9-0.9-1.01.01.0-1.00.91.11.11.21.2
Cocaine response after cond. not corrected0.50.81.4-0.70.7-0.6-0.6-0.90.90.9-0.90.91.01.01.21.2
Cocaine response before conditioning0.10.10.40.0-0.60.50.60.2-0.2-0.20.2-0.1-0.2-0.2-0.2-0.2
Saline control response0.30.40.6-0.80.0-0.2-0.2-0.80.80.8-0.80.70.60.70.70.7
Bone: connectivity density1.11.72.11.2-1.21.21.21.3-1.3-1.31.3-1.3-1.2-1.3-1.5-1.4
Bone: cortical apparent density1.82.96.6-2.61.5-1.6-1.7-1.71.71.7-1.71.71.61.61.21.2
Bone: cortical area0.10.20.4-0.50.6-0.5-0.5-0.30.30.3-0.30.40.50.40.30.3
Bone: cortical porosity2.22.42.81.5-1.61.71.61.5-1.5-1.51.5-1.5-1.5-1.5-1.5-1.5
Bone: cortical porosity2.42.72.91.5-1.61.71.71.7-1.7-1.71.7-1.7-1.6-1.6-1.5-1.5
Bone: cortical thickness0.10.20.3-0.40.6-0.5-0.5-0.40.40.4-0.40.40.40.40.40.4
Bone: cortical thickness0.10.20.2-0.30.4-0.3-0.3-0.40.40.4-0.40.40.40.50.50.5
Bone: cortical tissue density1.52.56.2-2.51.4-1.4-1.5-1.61.61.6-1.61.51.51.41.11.1
Condit. Reinf. active minus inactive responses0.20.31.10.40.2-0.1-0.2-0.40.40.4-0.40.30.30.51.01.0
Condit. Reinf. active-inactive response ratio0.20.20.80.8-0.00.10.1-0.20.20.2-0.20.0-0.00.20.90.9
Condit. Reinf. active responses0.20.20.70.2-0.10.10.1-0.50.50.5-0.50.30.20.40.80.8
Condit. Reinf. inactive responses0.50.60.9-1.00.3-0.4-0.4-1.01.01.0-1.00.90.60.80.80.8
Incentive salience index mean0.10.10.20.5-0.30.40.3-0.10.10.1-0.1-0.0-0.10.00.40.5
Condit. Reinf. lever presses0.30.51.20.7-1.11.11.10.4-0.4-0.40.4-0.5-0.7-0.6-0.4-0.3
Condit. Reinf. active minus inactive responses0.20.41.11.1-0.70.70.70.6-0.6-0.60.6-0.6-0.5-0.4-0.1-0.1
Condit. Reinf. active-inactive response ratio0.81.22.51.6-1.21.21.21.1-1.1-1.11.1-1.1-1.2-1.0-0.8-0.8
Condit. Reinf. active responses0.10.10.4-0.10.3-0.3-0.3-0.30.30.3-0.30.30.40.40.60.6
Condit. Reinf. inactive responses0.81.21.9-1.41.2-1.2-1.2-1.01.01.0-1.01.11.21.10.90.8
Condit. Reinf. lever presses0.40.50.70.7-0.80.80.80.7-0.7-0.70.7-0.7-0.7-0.7-0.7-0.7
Condit. Reinf. lever reinforcers received0.20.30.5-0.30.4-0.4-0.4-0.50.50.5-0.50.50.60.60.70.7
Conditioned reinforcement - actives0.00.20.4-0.40.6-0.5-0.4-0.40.40.4-0.40.10.40.30.30.3
Conditioned reinforcement - inactives0.00.10.1-0.30.3-0.3-0.1-0.30.30.3-0.30.10.20.20.30.2
Conditioned locomotion1.01.52.8-1.51.6-1.7-1.4-1.11.11.1-1.11.11.31.10.90.8
Patch foraging indifference point 0 sec0.10.21.9-1.4-0.10.10.2-0.30.30.3-0.30.40.10.0-0.5-0.5
Patch foraging indifference point AUC0.51.32.6-1.21.6-1.4-1.4-1.11.11.1-1.11.00.91.00.80.9
Delay disc. indifference point, 0s delay0.20.30.8-0.9-0.1-0.2-0.2-0.60.60.6-0.60.60.70.50.40.4
Delay disc. indifference point, 16s delay0.10.21.01.0-0.30.30.20.4-0.4-0.40.4-0.5-0.1-0.20.20.1
Delay disc. indifference point, 2s delay0.30.30.6-0.80.2-0.1-0.1-0.60.60.6-0.60.60.60.60.60.6
Delay disc. indifference point, 24s delay0.10.20.80.7-0.90.70.90.2-0.2-0.20.2-0.3-0.4-0.30.00.0
Delay disc. indifference point, 4s delay0.60.71.0-0.70.4-0.5-0.6-0.80.80.8-0.80.91.00.81.01.0
Delay disc. indifference point, 8s delay0.00.10.20.1-0.2-0.1-0.0-0.10.10.1-0.10.10.40.30.50.5
Indifference point function ln k0.10.30.7-0.8-0.10.10.1-0.50.50.5-0.50.70.80.70.60.6
Indifference point function log k0.10.30.7-0.8-0.10.10.1-0.50.50.5-0.50.70.80.70.60.6
Patch foraging total patch changes 0 sec0.10.42.9-1.70.4-0.3-0.2-0.60.60.6-0.60.80.40.4-0.2-0.2
Patch foraging total patch changes 12 sec0.10.10.5-0.6-0.00.10.1-0.00.00.0-0.0-0.1-0.4-0.3-0.7-0.6
Patch foraging total patch changes 18 sec0.61.54.0-2.01.2-1.1-1.0-1.31.31.3-1.31.41.01.10.70.7
Patch foraging total patch changes 24 sec0.10.31.6-1.30.1-0.1-0.0-0.70.70.7-0.70.5-0.10.1-0.3-0.2
Patch foraging total patch changes 6 sec0.10.20.7-0.8-0.10.20.1-0.10.10.1-0.1-0.1-0.3-0.3-0.8-0.8
Patch foraging time to switch 0 sec0.31.21.81.3-1.01.01.01.1-1.1-1.11.1-1.2-0.9-1.1-1.1-1.1
Patch foraging water rate 0 sec0.31.11.6-1.30.6-0.7-0.7-1.11.11.1-1.11.20.91.11.11.1
Patch foraging water rate 12 sec0.00.10.7-0.9-0.2-0.00.0-0.40.40.4-0.40.40.30.2-0.1-0.1
Patch foraging water rate 18 sec0.30.61.30.5-1.10.90.90.7-0.7-0.70.7-0.7-0.8-0.8-0.8-0.8
Patch foraging water rate 24 sec0.00.00.10.3-0.30.10.10.1-0.1-0.10.1-0.10.10.00.10.1
Patch foraging water rate 6 sec0.00.00.1-0.3-0.0-0.2-0.2-0.20.20.2-0.20.20.40.20.0-0.0
Seeking ratio, delayed vs. immediate footshock0.20.30.90.9-0.50.20.10.7-0.7-0.70.7-0.6-0.2-0.3-0.2-0.3
Distance traveled before self-admin0.81.82.21.3-1.11.21.11.4-1.4-1.41.4-1.5-1.4-1.3-1.4-1.4
Distance traveled after self-admin3.45.96.82.5-2.22.32.22.6-2.6-2.62.6-2.4-2.3-2.4-2.4-2.4
Extensor digitorum longus weight6.526.033.4-5.85.0-5.1-5.1-5.15.15.1-5.15.25.05.14.84.8
Bone: elastic displacement1.01.32.61.6-0.60.60.61.3-1.3-1.31.3-1.2-0.9-1.0-1.2-1.2
Bone: elastic work0.60.81.41.2-0.50.50.51.1-1.1-1.11.1-0.9-0.7-0.8-0.8-0.8
Bone: endosteal estimation0.00.00.00.10.1-0.0-0.00.1-0.1-0.10.10.00.10.00.00.0
Bone: endosteal perimeter0.00.10.20.10.5-0.4-0.40.1-0.1-0.10.1-0.00.30.20.30.2
Epididymis fat weight0.20.91.5-1.01.1-1.2-1.1-0.70.70.7-0.71.01.21.01.01.0
Delta time in closed arm before/after self-admin0.50.51.10.3-0.50.50.40.7-0.7-0.70.7-0.6-0.6-0.8-1.0-1.0
Delta time in open arm before/after self-admin0.10.10.30.6-0.20.30.40.4-0.4-0.40.4-0.5-0.4-0.3-0.2-0.2
Diff in mean of infusions in LGA sessions0.20.30.70.3-0.70.70.60.4-0.4-0.40.4-0.3-0.8-0.6-0.7-0.7
Delay discount exponential model param0.30.41.10.2-0.20.30.30.6-0.6-0.60.6-0.6-0.8-0.7-1.1-1.0
Extinction: sum of active levers before priming0.40.61.01.0-0.60.60.60.9-0.9-0.90.9-0.7-1.0-0.7-0.6-0.6
Active lever presses in extinction session 61.11.11.5-0.81.0-1.1-1.0-0.90.90.9-0.91.11.01.11.21.2
Bone: final force0.00.10.4-0.6-0.10.20.3-0.20.20.2-0.20.20.10.10.20.3
Bone: final moment0.00.10.4-0.6-0.10.20.3-0.20.20.2-0.20.20.20.20.30.3
Food consumed during 24 hour testing period0.61.31.6-0.91.2-1.3-1.3-1.01.01.0-1.01.01.11.11.21.2
Glucose0.10.10.20.5-0.30.30.40.3-0.3-0.30.3-0.4-0.4-0.3-0.2-0.2
Heart weight0.10.10.2-0.40.5-0.4-0.4-0.30.30.3-0.30.30.30.20.10.1
Delay discount hyperbolic model param0.40.51.20.4-0.20.30.30.7-0.7-0.70.7-0.7-0.8-0.8-1.1-1.1
Intermittent access intake day 1-15 change0.20.81.71.3-0.90.70.81.0-1.0-1.01.0-1.0-0.8-0.8-0.6-0.6
Intermittent access intake escalation0.21.11.91.4-1.00.81.01.1-1.1-1.11.1-1.3-1.0-1.0-0.9-0.9
Intermittent access intake escalation 21.32.13.81.9-1.21.11.21.6-1.6-1.61.6-1.7-1.5-1.4-1.3-1.3
Intermitt. access day 1 inactive lever presses0.00.10.10.3-0.40.20.20.3-0.3-0.30.3-0.20.1-0.10.0-0.0
Intermitt. access day 15 inactive lever presses0.00.00.1-0.20.3-0.4-0.3-0.10.10.1-0.1-0.2-0.1-0.0-0.2-0.2
Intermitt. access escalation Index0.10.21.01.0-0.30.40.30.4-0.4-0.40.4-0.5-0.4-0.30.10.1
Intermittent access day 1 total infusions0.10.41.2-0.41.1-0.5-0.5-0.70.70.7-0.70.40.30.40.50.5
Intermittent access day 15 total infusions0.20.41.01.0-0.20.60.70.6-0.6-0.60.6-0.8-0.8-0.7-0.5-0.5
Intermittent access terminal intake (last 3 days)0.00.00.10.30.4-0.2-0.00.1-0.1-0.10.1-0.3-0.3-0.2-0.1-0.1
Intermittent access total infusions0.00.00.10.20.30.10.20.1-0.1-0.10.1-0.3-0.3-0.2-0.1-0.2
Intermittent access day 1 locomotion0.40.81.4-0.91.2-0.9-0.8-0.90.90.9-0.90.80.80.80.80.7
Intermittent access day 15 total locomotion0.10.30.5-0.60.7-0.5-0.5-0.60.60.6-0.60.50.40.50.50.4
Intermittent access total locomotion0.60.71.5-0.91.2-0.9-0.8-0.90.90.9-0.90.70.60.70.60.6
Intermittent access standard deviation0.10.40.80.9-0.40.50.60.7-0.7-0.70.7-0.7-0.6-0.5-0.4-0.4
Left kidney weight0.10.71.50.6-1.21.01.10.6-0.6-0.60.6-0.7-1.0-0.9-0.9-0.9
Right kidney weight0.00.10.1-0.3-0.20.10.2-0.30.30.3-0.30.20.20.10.10.1
Cocaine induced anxiety0.00.00.1-0.2-0.00.00.0-0.20.20.2-0.20.20.10.10.20.2
Post-drug Anxiety0.91.01.1-0.90.8-0.9-0.9-1.11.11.1-1.11.00.91.01.11.1
Baseline Anxiety0.91.52.1-1.01.1-1.3-1.3-1.21.21.2-1.21.11.21.31.51.5
Tail length0.42.14.02.0-1.91.61.61.4-1.4-1.41.4-1.3-1.4-1.3-0.9-0.9
Length with tail0.42.03.71.8-1.91.61.71.3-1.3-1.31.3-1.2-1.5-1.3-0.8-0.8
Length without tail0.00.10.2-0.5-0.20.00.1-0.30.30.3-0.30.30.00.20.20.2
Times rat made contact with spout0.30.30.60.8-0.60.60.60.5-0.5-0.50.5-0.6-0.5-0.6-0.4-0.4
Lifetime Intake0.10.10.8-0.30.9-0.4-0.3-0.40.40.4-0.40.10.20.20.30.3
Liver weight, left0.00.00.1-0.20.10.10.00.1-0.1-0.10.10.10.0-0.1-0.2-0.2
Liver weight, right0.10.10.20.5-0.30.40.40.4-0.4-0.40.4-0.3-0.4-0.4-0.3-0.4
Locomotor activity0.30.40.80.9-0.40.30.40.8-0.8-0.80.8-0.6-0.5-0.5-0.5-0.6
Locomotor testing distance1.02.43.31.8-1.21.31.31.7-1.7-1.71.7-1.6-1.5-1.5-1.5-1.6
Locomotor testing rearing1.03.65.52.3-1.81.71.82.0-2.0-2.02.0-2.0-1.8-1.9-1.7-1.7
Locomotion in novel chamber6.79.010.7-3.32.9-3.1-3.1-3.03.03.0-3.03.03.03.02.82.8
Locomotion in novel chamber post-restriction1.64.87.0-2.02.6-2.6-2.6-2.02.02.0-2.02.12.22.12.02.0
Fecal boli incidents, locomotor time 10.82.02.2-1.41.3-1.4-1.2-1.41.41.4-1.41.51.41.51.51.5
Change in fecal boli incidents, locomotor task0.10.10.4-0.1-0.40.60.50.2-0.2-0.20.2-0.2-0.2-0.4-0.5-0.5
Time >=10cm from walls, locomotor time 11.51.82.4-1.61.5-1.4-1.4-1.31.31.3-1.31.31.41.31.11.1
Bouts of movement, locomotor time 18.210.711.9-3.13.4-3.4-3.4-3.23.23.2-3.23.32.93.33.43.4
Total resting periods, locomotor time 19.711.112.2-3.23.5-3.5-3.5-3.33.33.3-3.33.42.93.43.43.5
Rest time, locomotor task time 10.71.12.3-0.61.3-1.5-1.4-0.90.90.9-0.90.90.71.01.11.2
Distance moved, locomotor task time 10.20.40.80.2-0.60.90.80.5-0.5-0.50.5-0.5-0.6-0.7-0.9-0.9
Vertical activity count, locomotor time 10.31.82.41.2-1.31.41.51.3-1.3-1.31.3-1.3-1.2-1.4-1.5-1.6
Time >=10cm from walls, locomotor time 20.00.00.0-0.00.0-0.1-0.00.0-0.0-0.00.0-0.20.1-0.0-0.1-0.2
Bouts of movement, locomotor time 21.34.46.2-2.02.3-2.5-2.5-2.02.02.0-2.02.02.12.02.01.9
Total resting periods, locomotor time 20.93.85.7-1.92.1-2.4-2.3-1.91.91.9-1.91.81.91.81.71.6
Rest time, locomotor task time 20.10.10.20.30.0-0.2-0.10.3-0.3-0.30.3-0.3-0.5-0.3-0.4-0.3
Distance moved, locomotor task time 20.20.30.8-0.90.0-0.0-0.0-0.60.60.6-0.60.60.30.50.40.4
Vertical activity count, locomotor time 20.20.40.6-0.50.6-0.6-0.6-0.60.60.6-0.60.60.70.70.80.7
Light reinforcement 11.56.612.5-3.52.3-2.3-2.3-2.62.62.6-2.62.72.62.52.12.1
Light reinforcement 20.92.04.9-2.21.3-1.4-1.4-1.41.41.4-1.41.51.51.30.80.8
Bone: marrow area0.00.00.0-0.00.2-0.1-0.10.0-0.0-0.00.00.10.10.10.10.1
Bone: maximum diameter0.00.10.10.30.10.00.00.3-0.3-0.30.3-0.2-0.2-0.2-0.3-0.3
Bone: maximum force0.10.20.7-0.80.4-0.2-0.2-0.40.40.4-0.40.40.50.40.50.5
Bone: maximum moment0.10.30.8-0.90.4-0.3-0.3-0.50.50.5-0.50.50.60.50.50.5
Mean time between licks in bursts0.31.64.1-2.01.3-1.2-1.2-1.31.31.3-1.31.31.31.10.70.7
Mean num. licks in bursts0.10.30.5-0.50.5-0.5-0.5-0.50.50.5-0.50.50.70.60.60.6
Cd content in liver2.32.55.72.4-1.71.71.71.6-1.6-1.61.6-1.6-1.6-1.4-1.0-1.0
Co content in liver0.70.81.71.3-1.01.01.00.9-0.9-0.90.9-0.9-1.0-0.8-0.3-0.2
Cu content in liver0.30.30.60.8-0.70.70.70.5-0.5-0.50.5-0.6-0.7-0.5-0.1-0.1
Fe content in liver3.03.74.42.0-2.12.12.11.8-1.8-1.81.8-1.7-1.9-1.9-2.0-2.0
K content in liver1.01.01.9-1.41.0-1.0-1.0-1.01.01.0-1.01.11.00.90.50.5
Mg content in liver0.00.00.2-0.40.1-0.1-0.1-0.00.00.0-0.00.20.20.1-0.0-0.0
Mn content in liver0.20.31.0-1.00.5-0.5-0.5-0.40.40.4-0.40.50.50.50.40.4
Na content in liver2.12.44.11.1-1.51.51.51.4-1.4-1.41.4-1.5-1.5-1.6-2.0-2.0
Rb content in liver6.47.48.6-2.92.5-2.5-2.5-2.82.82.8-2.82.62.72.72.92.9
Se content in liver0.91.11.3-0.81.1-1.1-1.1-1.11.11.1-1.11.11.01.00.90.9
Sr content in liver0.00.00.10.4-0.20.20.20.1-0.1-0.10.1-0.1-0.1-0.1-0.1-0.1
Zn content in liver0.20.20.40.6-0.50.50.50.5-0.5-0.50.5-0.5-0.5-0.4-0.2-0.2
Bone: minimum diameter0.40.81.0-1.01.0-0.9-0.8-0.90.90.9-0.91.00.90.90.70.7
Time in familiar zone, hab. session 10.00.00.20.4-0.10.10.10.1-0.1-0.10.10.0-0.00.10.30.3
Time in novel zone, hab. session 10.91.01.31.0-1.01.01.00.9-0.9-0.90.9-1.1-1.1-1.1-1.1-1.1
Total zone transitions, hab. session 10.10.10.30.1-0.40.40.40.3-0.3-0.30.3-0.3-0.3-0.4-0.5-0.5
Total locomotion distance, hab. session 10.71.01.5-1.21.0-1.0-1.0-1.01.01.0-1.01.01.01.00.90.9
Locomotion velocity, hab. session 10.60.91.5-1.20.9-0.9-0.9-0.90.90.9-0.90.91.00.90.70.7
Time in familiar zone, hab. session 20.50.60.80.8-0.90.90.80.7-0.7-0.70.7-0.8-0.8-0.8-0.8-0.8
Time in novel zone, hab. session 20.00.00.10.00.2-0.2-0.1-0.10.10.1-0.10.10.20.20.30.3
Total zone transitions, hab. session 20.50.70.8-0.70.8-0.8-0.8-0.80.80.8-0.80.80.80.80.90.9
Total locomotion distance, hab. session 21.62.12.6-1.21.5-1.5-1.5-1.41.41.4-1.41.41.41.51.61.6
Locomotion velocity, hab. session 21.41.82.1-1.21.4-1.4-1.4-1.31.31.3-1.31.31.41.31.41.4
Novel to familiar place preference ratio0.10.10.1-0.30.1-0.1-0.1-0.30.30.3-0.30.30.40.30.40.3
Novelty place preference0.00.00.1-0.10.0-0.1-0.1-0.20.20.2-0.20.20.30.20.30.3
Time in novel zone, NPP test0.00.00.00.1-0.10.10.1-0.00.00.0-0.00.00.10.00.10.1
Total zone transitions, NPP test0.40.60.9-0.50.9-0.8-0.9-0.70.70.7-0.70.70.70.80.90.9
Total locomotion distance, NPP test0.71.01.4-0.81.2-1.1-1.2-0.90.90.9-0.90.91.00.90.90.9
Locomotion velocity, NPP test1.01.52.0-1.21.4-1.4-1.4-1.21.21.2-1.21.11.21.11.11.1
Intraocular pressure2.74.45.2-1.71.9-2.0-2.0-2.12.12.1-2.12.12.32.22.32.3
Delta distance traveled before/after self-admin0.40.40.50.6-0.70.70.70.7-0.7-0.70.7-0.5-0.4-0.6-0.5-0.6
Delta ambulatory time before/after self-admin0.10.10.20.2-0.40.40.30.4-0.4-0.40.4-0.2-0.2-0.3-0.4-0.4
Parametrial fat weight0.61.33.3-0.91.8-1.7-1.6-0.80.80.8-0.80.91.11.10.90.9
Pavlov. Cond. lever latency0.81.01.5-1.21.2-1.2-1.2-0.90.90.9-0.90.90.90.90.70.7
Pavlov. Cond. magazine entry latency0.20.20.40.5-0.60.70.60.4-0.4-0.40.4-0.4-0.6-0.4-0.3-0.3
Pavlov. Cond. change in total contacts0.20.30.6-0.40.1-0.1-0.2-0.60.60.6-0.60.60.30.50.70.8
Pavlov. Cond. index score0.40.50.80.8-0.90.90.80.6-0.6-0.60.6-0.6-0.7-0.6-0.4-0.4
Pavlov. Cond. latency score0.50.71.01.0-1.01.00.90.8-0.8-0.80.8-0.7-0.8-0.7-0.5-0.5
Pavlov. Cond. lever contacts0.30.40.70.7-0.80.80.80.6-0.6-0.60.6-0.6-0.6-0.6-0.4-0.4
Pavlov. Cond. magazine entry number0.91.21.7-1.31.2-1.3-1.2-1.01.01.0-1.01.01.21.00.80.7
Pavlov. Cond. intertrial magazine entries0.50.61.0-0.40.8-0.9-0.9-0.60.60.6-0.60.70.90.81.01.0
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.4-0.50.50.50.2-0.2-0.20.2-0.2-0.3-0.20.00.0
Pavlov. Cond. response bias0.20.30.70.6-0.80.80.80.4-0.4-0.40.4-0.4-0.6-0.4-0.2-0.2
Pavlov. Cond. lever latency1.11.52.1-1.01.4-1.5-1.4-1.11.11.1-1.11.21.21.31.31.3
Pavlov. Cond. magazine entry latency0.81.21.41.0-1.01.21.21.0-1.0-1.01.0-1.1-1.1-1.1-1.1-1.1
Pavlov. Cond. change in total contacts0.51.11.50.7-1.21.21.21.0-1.0-1.01.0-1.0-1.0-1.0-1.1-1.1
Pavlov. Cond. index score0.71.11.60.7-1.21.31.30.9-0.9-0.90.9-0.9-1.0-1.1-1.2-1.1
Pavlov. Cond. latency score0.40.71.10.5-1.01.01.00.7-0.7-0.70.7-0.7-0.8-0.9-1.0-1.0
Pavlov. Cond. lever contacts1.72.53.21.3-1.81.81.81.5-1.5-1.51.5-1.5-1.6-1.6-1.6-1.6
Pavlov. Cond. magazine entry number1.31.72.3-1.01.4-1.5-1.5-1.21.21.2-1.21.21.21.41.41.4
Pavlov. Cond. intertrial magazine entries2.35.05.5-2.12.1-2.2-2.2-2.22.22.2-2.22.22.32.32.42.3
Pavlov. Cond. lever-magazine prob. diff.0.50.81.30.5-1.11.11.10.7-0.7-0.70.7-0.8-0.8-0.9-1.0-1.0
Pavlov. Cond. response bias2.83.94.81.7-2.12.22.21.9-1.9-1.91.9-1.9-2.0-2.0-2.1-2.1
Time in closed arm before self-admin0.10.20.50.6-0.70.60.70.2-0.2-0.20.2-0.3-0.3-0.20.20.2
Time in closed arm after self-admin1.11.21.81.1-1.31.31.31.0-1.0-1.01.0-1.1-1.1-1.2-1.1-1.1
Time in open arm before self-admin1.01.32.1-1.51.3-1.2-1.3-1.11.11.1-1.11.11.01.00.80.8
Time in open arm after self-admin0.00.10.10.20.2-0.2-0.10.3-0.3-0.30.3-0.3-0.2-0.1-0.2-0.2
Bone: periosteal estimation0.00.00.00.10.2-0.00.00.1-0.1-0.10.1-0.10.0-0.00.0-0.0
Bone: periosteal perimeter0.00.00.30.50.2-0.1-0.10.3-0.3-0.30.3-0.10.10.00.10.1
Bone: post-yield work0.00.00.2-0.5-0.20.20.30.0-0.0-0.00.0-0.1-0.1-0.2-0.1-0.1
Progressive ratio test 1 active lever presses0.81.52.2-1.11.5-1.1-1.0-1.31.31.3-1.31.11.21.11.21.1
Progressive ratio test 1 breakpoint0.71.32.0-1.01.4-1.0-0.9-1.21.21.2-1.21.01.21.01.11.1
Progressive ratio test 1 inactive lever presses0.10.20.5-0.70.5-0.3-0.2-0.40.40.4-0.40.30.40.30.20.2
Progressive ratio test 2 active lever presses0.20.31.1-0.31.0-0.5-0.4-0.50.50.5-0.50.20.50.40.50.5
Progressive ratio test 2 breakpoint0.30.31.1-0.31.0-0.5-0.4-0.60.60.6-0.60.30.50.50.60.5
Progressive ratio test 2 inactive lever presses0.00.00.10.10.40.10.30.1-0.1-0.10.1-0.3-0.2-0.2-0.1-0.2
Incentive Sensitization - Responses0.10.40.70.8-0.30.40.50.6-0.6-0.60.6-0.8-0.7-0.6-0.5-0.5
Incentive Sensitization - Breakpoint0.10.30.50.7-0.30.40.50.5-0.5-0.50.5-0.7-0.6-0.5-0.4-0.4
Sum of active levers in priming session hrs 5-61.31.21.41.0-1.01.01.01.2-1.2-1.21.2-1.0-1.1-1.1-1.1-1.1
Progressive ratio1.54.45.9-1.81.9-2.0-2.0-2.02.02.0-2.02.12.22.22.42.4
Food seeking constrained by brief footshock0.00.00.1-0.2-0.0-0.2-0.2-0.10.10.1-0.10.20.40.20.20.2
Seeking ratio, punishment vs. effort0.71.52.40.9-1.11.11.01.1-1.1-1.11.1-1.3-1.4-1.3-1.6-1.6
Retroperitoneal fat weight0.62.84.6-1.72.1-2.1-2.0-1.51.51.5-1.51.61.61.61.51.5
Reaction time number correct0.41.32.3-1.50.5-0.7-0.7-1.31.31.3-1.31.21.11.11.11.1
Reaction time mean minus median0.32.22.91.7-1.11.21.21.7-1.7-1.71.7-1.5-1.4-1.4-1.4-1.4
Reaction time mean minus median AUC0.32.23.11.8-1.31.41.31.6-1.6-1.61.6-1.6-1.3-1.4-1.3-1.4
Reaction time num false alarms1.11.82.0-1.41.4-1.4-1.4-1.31.31.3-1.31.31.21.41.41.4
Reaction time num false alarms AUC1.12.63.4-1.81.6-1.6-1.6-1.61.61.6-1.61.61.51.61.51.6
Reaction time trials correct on left0.41.32.3-1.50.5-0.7-0.7-1.31.31.3-1.31.21.11.11.11.1
Reaction time trials on left0.31.12.0-1.40.4-0.6-0.6-1.21.21.2-1.21.11.01.11.11.0
Reaction time mean1.53.45.32.3-1.71.91.91.8-1.8-1.81.8-1.8-1.9-1.8-1.5-1.5
Reaction time mean AUC0.92.34.02.0-1.41.61.61.5-1.5-1.51.5-1.5-1.6-1.5-1.2-1.1
Median of all reaction times1.62.64.52.1-1.61.81.81.5-1.5-1.51.5-1.6-1.8-1.6-1.2-1.2
Reaction time omissions1.11.72.21.5-1.41.51.41.3-1.3-1.31.3-1.3-1.3-1.3-1.1-1.1
Reaction time false alarm rate0.50.71.4-0.81.2-1.1-1.1-0.70.70.7-0.70.80.70.80.80.8
Reaction time premature initiation rate0.10.20.40.6-0.40.40.50.5-0.5-0.50.5-0.5-0.4-0.5-0.5-0.5
Reaction time premature initiations0.00.00.0-0.2-0.10.10.1-0.20.20.2-0.20.10.10.10.10.0
Std. dev. reaction times1.34.35.32.3-1.81.91.92.2-2.2-2.22.2-2.1-2.0-2.0-2.0-2.0
Reaction time trials completed0.31.12.0-1.40.4-0.6-0.6-1.21.21.2-1.21.11.01.11.11.0
Reaction time trials AUC0.31.12.0-1.40.4-0.5-0.6-1.21.21.2-1.21.11.01.11.11.0
Run reversals in cocaine runway, females0.60.71.6-0.41.3-1.2-1.2-0.70.70.7-0.70.70.60.70.90.8
Run reversals in cocaine runway, males0.50.50.7-0.70.9-0.9-0.8-0.70.70.7-0.70.70.70.70.70.6
Latency to leave start box in cocaine runway1.72.33.4-1.51.7-1.8-1.8-1.51.51.5-1.51.31.51.51.31.3
Latency to leave start box in cocaine runway, F0.20.31.0-0.50.8-1.0-1.0-0.30.30.3-0.30.30.50.40.20.1
Latency to leave start box in cocaine runway, M4.74.55.6-2.01.8-1.8-1.9-2.42.42.4-2.41.92.12.12.22.2
Std. dev. time between licks in bursts0.51.02.4-1.50.7-0.6-0.6-1.21.21.2-1.21.00.90.90.60.6
Total sessions with >9 infusions1.72.13.4-1.81.8-1.6-1.5-1.41.41.4-1.41.31.51.41.11.1
Short access day 1 total inactive lever presses0.20.40.9-1.00.8-0.7-0.6-0.70.70.7-0.70.40.70.50.30.2
Short access day 10 total inactive lever presses0.00.30.50.7-0.70.40.40.6-0.6-0.60.6-0.6-0.5-0.4-0.3-0.3
Short access day 1 total infusions1.01.93.2-1.61.8-1.4-1.3-1.41.41.4-1.41.21.41.31.11.0
Short access day 10 total infusions0.50.81.1-0.71.0-1.0-0.8-1.01.01.0-1.00.70.70.80.90.9
Short access total infusions1.31.83.4-1.31.9-1.5-1.3-1.41.41.4-1.41.11.31.31.31.3
Short access day 1 locomotion1.01.63.3-1.80.8-0.9-0.7-1.51.51.5-1.51.41.21.21.11.0
Short access day 10 total locomotion0.00.00.1-0.1-0.1-0.3-0.1-0.00.00.0-0.00.00.0-0.0-0.1-0.1
Short access total locomotion1.21.82.4-1.51.3-1.4-1.2-1.41.41.4-1.41.41.31.31.21.2
One hour access (0.3 mA shock)0.10.20.3-0.00.5-0.5-0.4-0.40.40.4-0.40.30.20.30.50.5
Compulsive drug intake0.10.10.40.0-0.40.20.30.2-0.2-0.20.2-0.3-0.4-0.4-0.6-0.6
One hour access (shock baseline)0.00.00.20.30.10.10.00.0-0.0-0.00.0-0.00.10.10.40.4
Social response proportion0.20.31.50.4-1.21.01.0-0.20.20.2-0.2-0.2-0.5-0.4-0.1-0.1
Social responses0.70.91.81.3-1.20.90.90.8-0.8-0.80.8-1.0-1.0-1.0-0.7-0.7
Social time3.86.07.62.7-2.82.62.62.3-2.3-2.32.3-2.4-2.4-2.5-2.3-2.3
Soleus weight0.72.23.5-1.91.5-1.6-1.5-1.61.61.6-1.61.51.41.30.90.9
Bone: stiffness0.20.41.6-1.20.1-0.0-0.0-0.70.70.7-0.70.60.30.40.50.6
Tibialis anterior weight2.37.911.3-3.42.5-2.7-2.7-2.92.92.9-2.92.92.92.82.52.5
Time to tail flick, vehicle, before self-admin0.00.00.10.20.1-0.1-0.20.2-0.2-0.20.2-0.10.00.00.10.1
Time to tail flick, vehicle, after self-admin0.10.20.50.7-0.40.40.50.4-0.4-0.40.4-0.4-0.5-0.3-0.2-0.2
Time to tail flick, test, before self-admin1.21.31.8-1.11.3-1.3-1.3-1.01.01.0-1.01.11.31.21.21.2
Time to tail flick, test, after self-admin3.13.33.9-1.71.8-1.7-1.8-1.81.81.8-1.81.91.91.92.02.0
Delta time to tail flick, vehicle, before/after SA0.00.00.10.0-0.30.30.4-0.00.00.0-0.0-0.0-0.2-0.1-0.1-0.1
Delta time to tail flick, test, before/after SA0.10.10.1-0.30.1-0.0-0.1-0.30.30.3-0.30.30.20.20.30.2
Tibia length0.20.60.80.5-0.80.90.80.8-0.8-0.80.8-0.8-0.7-0.8-0.8-0.9
Ambulatory time before self-admin0.51.52.01.4-0.91.01.01.3-1.3-1.31.3-1.4-1.2-1.2-1.2-1.2
Ambulatory time after self-admin1.82.93.41.7-1.41.51.41.8-1.8-1.81.8-1.7-1.5-1.7-1.8-1.8
Bone: tissue strength0.10.10.2-0.40.3-0.3-0.3-0.30.30.3-0.30.40.30.30.50.5
Total heroin consumption0.10.10.2-0.10.2-0.1-0.1-0.20.20.2-0.20.40.10.30.40.4
Bone: trabecular number4.07.48.22.3-2.62.62.62.9-2.9-2.92.9-2.8-2.7-2.8-2.8-2.7
Bone: trabecular spacing3.04.44.7-1.82.1-2.0-2.1-2.12.12.1-2.12.12.12.12.22.1
Bone: trabecular thickness6.28.69.33.0-2.92.82.93.0-3.0-3.03.0-3.0-3.0-3.0-2.8-2.8
Bone: trabecular tissue density0.10.10.2-0.3-0.40.40.30.4-0.4-0.40.4-0.5-0.3-0.4-0.3-0.3
Water consumed over 24 hours0.10.10.40.00.1-0.1-0.1-0.40.40.4-0.40.30.20.30.60.6
Number of responses in last shaping day0.00.00.10.20.3-0.10.0-0.10.10.1-0.1-0.20.0-0.0-0.0-0.0