Hub : Genes

Bahcc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	isoform ratio	XM_063270199.1	0.03	0.02	6.8e-03	0.01	0.03	0.01	0.01	3.3e-02	1.9e-03	1.4e-02	2.0e-02
2	Liver	mRNA stability	Bahcc1	0.86	0.13	0.0e+00	0.54	0.56	0.55	0.55	8.0e-72	4.0e-74	2.0e-72	3.3e-73
3	Adipose	mRNA stability	Bahcc1	0.04	0.03	1.5e-04	0.02	0.02	0.02	0.02	2.3e-03	1.2e-03	6.0e-03	3.9e-03
4	Liver	gene expression	Bahcc1	0.03	0.02	1.3e-03	0.02	0.01	0.01	0.01	2.6e-03	7.8e-03	2.8e-02	7.9e-03
5	Brain	mRNA stability	Bahcc1	0.06	0.05	3.1e-03	0.02	0.02	0.02	0.02	5.8e-03	5.1e-03	5.3e-03	9.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	0.1	0.1	0.0	-0.0	-0.3
Area under the delay curve	1.3	1.5	1.9	-1.4	-1.4	-1.3	1.2	-0.7
BMI with tail	0.0	0.1	0.1	0.3	0.3	0.1	-0.4	-0.2
BMI without tail	0.5	1.5	2.6	1.6	1.3	1.2	-1.3	0.0
Body weight	1.6	7.0	9.9	3.1	3.0	2.8	-2.6	1.4
Weight adjusted by age	1.5	2.2	3.5	1.9	1.6	1.6	-1.4	0.9
Bone surface	0.2	0.4	0.6	0.8	0.8	0.8	-0.6	0.3
Bone volume	0.1	0.2	0.3	0.6	0.6	0.5	-0.5	0.1
Breakpoint value in progressive ratio session	1.5	1.8	3.0	1.0	1.1	1.0	-1.7	1.7
Number of licking bursts	0.1	0.1	0.5	0.1	0.0	0.0	0.5	-0.7
Context. condit. distance diff. score	1.0	1.2	2.9	-0.7	-0.8	-1.0	1.0	-1.7
Locomotion velocity, session 1	0.2	0.2	0.7	-0.5	-0.3	-0.2	-0.0	0.8
Locomotion distance, session 1	3.5	4.4	5.1	-2.2	-2.3	-2.2	2.1	-1.7
Locomotion velocity, session 2	1.5	1.8	2.7	-1.7	-1.5	-1.3	1.4	-0.5
Locomotion distance, session 2	1.2	1.7	1.9	-1.3	-1.3	-1.3	1.3	-1.4
Locomotion velocity, session 3	0.2	0.3	0.5	-0.7	-0.6	-0.5	0.3	0.3
Locomotion distance, session 3	1.7	1.9	2.9	-1.7	-1.5	-1.5	1.3	-0.6
Stereotopy head waving bouts, day 3	0.0	0.0	0.2	-0.1	-0.1	0.0	-0.0	0.4
Stereotopy head waving duration, day 3	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.3	-0.0
Locomotion velocity, session 7	0.6	0.7	0.9	-1.0	-0.9	-0.9	0.7	-0.6
Locomotion distance, session 7	5.4	6.8	7.8	-2.8	-2.8	-2.8	2.4	-2.3
Stereotopy head waving bouts, day 7	0.2	0.2	0.2	0.5	0.4	0.4	-0.5	0.4
Stereotopy head waving duration, day 7	0.3	0.4	0.7	0.8	0.7	0.7	-0.5	0.3
Locomotion velocity, session 8	2.2	2.6	2.9	-1.5	-1.6	-1.6	1.6	-1.7
Locomotion distance, session 8	3.2	4.6	7.9	-1.7	-1.9	-2.1	2.1	-2.8
Degree of sensitization distance	0.2	0.2	0.8	-0.2	-0.3	-0.3	0.3	-0.9
Degree of sensitization stereotypy	0.0	0.0	0.1	0.3	0.2	0.2	-0.2	0.0
Conditioned locomotion	0.5	0.6	1.1	1.1	0.9	0.7	-0.5	-0.4
Cocaine response after cond. corrected	0.1	0.2	0.7	-0.1	0.1	0.1	-0.4	0.8
Cocaine response after cond. not corrected	0.1	0.1	0.3	-0.5	-0.4	-0.3	0.1	0.4
Cocaine response before conditioning	0.9	1.1	1.5	-1.0	-1.0	-0.9	1.2	-1.1
Saline control response	1.0	1.4	2.3	1.5	1.4	1.3	-1.0	0.2
Bone: connectivity density	0.4	0.6	1.3	-0.5	-0.5	-0.6	0.8	-1.1
Bone: cortical apparent density	1.3	1.8	2.9	-1.7	-1.5	-1.5	1.2	-0.5
Bone: cortical area	5.0	7.7	10.0	3.2	3.1	3.0	-2.7	1.8
Bone: cortical porosity	4.5	4.9	6.8	1.9	2.1	2.1	-2.3	2.6
Bone: cortical porosity	4.6	5.0	6.2	2.0	2.1	2.1	-2.3	2.5
Bone: cortical thickness	5.8	9.7	11.3	3.4	3.3	3.2	-3.1	2.4
Bone: cortical thickness	1.3	1.6	1.7	1.3	1.3	1.2	-1.3	1.1
Bone: cortical tissue density	1.4	1.9	3.1	-1.7	-1.6	-1.5	1.2	-0.5
Condit. Reinf. active minus inactive responses	0.7	0.8	1.3	1.1	1.0	0.9	-0.8	0.3
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	0.7	0.6	0.5	-0.6	0.3
Condit. Reinf. active responses	1.3	1.6	2.7	1.7	1.4	1.4	-1.0	0.3
Condit. Reinf. inactive responses	0.3	0.3	0.6	0.8	0.6	0.6	-0.5	0.1
Incentive salience index mean	0.5	0.6	1.2	1.1	0.9	0.9	-0.6	0.1
Condit. Reinf. lever presses	0.2	0.3	0.7	-0.3	-0.4	-0.4	0.7	-0.8
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	0.4	0.3	0.3	-0.1	-0.2
Condit. Reinf. active-inactive response ratio	1.7	2.0	2.7	1.6	1.5	1.6	-1.3	1.0
Condit. Reinf. active responses	0.2	0.3	0.4	-0.5	-0.6	-0.6	0.5	-0.6
Condit. Reinf. inactive responses	1.6	2.0	2.5	-1.6	-1.6	-1.6	1.3	-1.0
Condit. Reinf. lever presses	0.3	0.4	0.6	-0.6	-0.7	-0.8	0.5	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	0.8	-0.7	-0.8	-0.9	0.7	-0.8
Conditioned reinforcement - actives	0.1	0.2	0.4	-0.3	-0.4	-0.4	0.6	-0.5
Conditioned reinforcement - inactives	0.3	0.4	0.6	0.7	0.8	0.6	-0.4	0.4
Conditioned locomotion	0.0	0.0	0.2	0.1	-0.0	-0.1	0.4	-0.2
Patch foraging indifference point 0 sec	0.0	0.1	0.2	0.2	0.2	0.1	-0.5	0.3
Patch foraging indifference point AUC	0.0	0.1	0.1	-0.2	-0.3	-0.3	0.2	-0.3
Delay disc. indifference point, 0s delay	0.0	0.0	0.1	0.0	-0.2	-0.1	0.2	-0.2
Delay disc. indifference point, 16s delay	3.7	4.0	4.5	-2.0	-2.0	-2.1	2.1	-1.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.1	-0.3	-0.4	-0.3	0.3	0.2
Delay disc. indifference point, 24s delay	1.3	1.4	2.5	-1.6	-1.4	-1.3	1.1	-0.0
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	-0.4	-0.3	0.2	0.1
Delay disc. indifference point, 8s delay	0.1	0.1	0.2	-0.5	-0.4	-0.3	0.3	0.3
Indifference point function ln k	0.5	1.0	1.4	-1.2	-1.0	-1.1	0.9	-0.6
Indifference point function log k	0.5	1.0	1.4	-1.2	-1.0	-1.1	0.9	-0.6
Patch foraging total patch changes 0 sec	0.0	0.0	0.1	0.0	0.0	-0.0	-0.4	0.2
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	0.4	0.4	0.4	-0.7	0.7
Patch foraging total patch changes 18 sec	0.6	0.9	1.2	-1.0	-1.0	-1.1	0.6	-0.9
Patch foraging total patch changes 24 sec	0.2	0.3	0.5	0.7	0.6	0.5	-0.6	0.3
Patch foraging total patch changes 6 sec	0.7	1.1	1.2	1.1	1.0	1.1	-1.1	0.9
Patch foraging time to switch 0 sec	0.1	0.2	0.3	-0.5	-0.4	-0.4	0.5	-0.1
Patch foraging water rate 0 sec	0.2	0.5	0.9	0.9	0.7	0.6	-0.8	0.1
Patch foraging water rate 12 sec	0.3	0.6	1.0	-0.7	-0.7	-0.9	0.6	-1.0
Patch foraging water rate 18 sec	0.2	0.3	0.9	-0.1	-0.3	-0.3	0.4	-1.0
Patch foraging water rate 24 sec	0.3	0.4	1.3	-0.2	-0.4	-0.6	0.4	-1.1
Patch foraging water rate 6 sec	0.2	0.2	0.6	-0.3	-0.4	-0.5	0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	0.5	0.6	1.1	1.0	0.8	0.9	-0.7	0.2
Distance traveled before self-admin	1.3	1.7	2.4	1.3	1.3	1.2	-1.5	1.3
Distance traveled after self-admin	0.0	0.0	0.1	0.2	0.1	-0.0	-0.3	-0.2
Extensor digitorum longus weight	0.4	1.4	2.6	-1.0	-1.2	-1.2	0.8	-1.6
Bone: elastic displacement	1.6	1.8	2.2	1.4	1.3	1.3	-1.5	1.1
Bone: elastic work	10.5	13.7	15.5	3.8	3.7	3.7	-3.9	3.3
Bone: endosteal estimation	0.4	0.8	1.2	-0.8	-0.9	-0.9	0.9	-1.1
Bone: endosteal perimeter	0.6	1.3	1.8	1.3	1.3	1.3	-1.0	0.7
Epididymis fat weight	0.2	0.7	1.2	1.1	1.0	0.8	-0.8	-0.1
Delta time in closed arm before/after self-admin	0.8	0.8	1.7	-0.3	-0.4	-0.5	1.2	-1.3
Delta time in open arm before/after self-admin	0.0	0.0	0.1	-0.2	-0.3	-0.3	0.1	-0.0
Diff in mean of infusions in LGA sessions	0.5	0.6	0.8	0.7	0.7	0.7	-0.8	0.9
Delay discount exponential model param	1.3	1.4	2.1	1.4	1.4	1.3	-1.1	0.4
Extinction: sum of active levers before priming	0.1	0.1	0.2	-0.4	-0.3	-0.3	0.1	0.2
Active lever presses in extinction session 6	1.3	1.3	3.7	0.5	0.7	0.7	-1.3	1.9
Bone: final force	3.9	6.2	8.3	2.9	2.7	2.6	-2.5	1.5
Bone: final moment	5.2	8.3	10.5	3.2	3.1	3.0	-2.9	1.9
Food consumed during 24 hour testing period	0.1	0.2	0.3	0.5	0.5	0.4	-0.4	0.3
Glucose	0.9	1.4	6.2	-0.7	-0.3	-0.0	-0.6	2.5
Heart weight	0.8	1.2	1.8	1.1	1.0	1.0	-1.3	1.1
Delay discount hyperbolic model param	1.0	1.1	1.7	1.3	1.2	1.1	-1.0	0.3
Intermittent access intake day 1-15 change	0.7	1.5	2.6	0.9	1.1	1.1	-1.6	1.3
Intermittent access intake escalation	0.6	1.3	2.2	0.9	1.0	1.0	-1.5	1.2
Intermittent access intake escalation 2	3.2	3.7	5.4	1.6	1.9	1.8	-2.3	1.9
Intermitt. access day 1 inactive lever presses	0.1	0.5	0.8	0.9	0.7	0.6	-0.8	0.1
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.2	0.2	0.1	-0.0	0.2	-0.5
Intermitt. access escalation Index	0.1	0.1	0.4	0.1	-0.1	-0.1	0.3	-0.6
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.0
Intermittent access day 15 total infusions	0.3	0.4	0.6	0.7	0.7	0.7	-0.8	0.5
Intermittent access terminal intake (last 3 days)	0.7	0.9	1.0	1.0	1.0	1.0	-1.0	0.7
Intermittent access total infusions	0.1	0.1	0.1	0.4	0.3	0.3	-0.4	0.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.1	0.1	0.0	0.3	-0.2
Intermittent access day 15 total locomotion	0.4	0.7	0.8	0.9	0.9	0.9	-0.8	0.7
Intermittent access total locomotion	0.2	0.2	0.3	0.5	0.6	0.5	-0.4	0.3
Intermittent access standard deviation	0.4	0.8	2.1	0.3	0.5	0.6	-1.1	1.5
Left kidney weight	0.2	1.1	1.2	1.0	1.1	1.1	-0.8	1.1
Right kidney weight	0.1	0.5	0.7	0.8	0.8	0.8	-0.4	0.6
Cocaine induced anxiety	3.9	5.5	7.2	2.1	2.1	2.2	-2.6	2.7
Post-drug Anxiety	2.2	2.4	5.1	0.9	1.2	1.1	-1.8	2.3
Baseline Anxiety	1.2	1.3	2.0	-1.4	-1.2	-1.2	1.2	-0.6
Tail length	2.3	9.1	13.4	3.7	3.3	3.3	-2.9	1.4
Length with tail	2.9	12.5	15.5	3.9	3.8	3.8	-3.3	2.7
Length without tail	1.8	5.6	6.4	2.3	2.4	2.4	-2.2	2.5
Times rat made contact with spout	2.9	3.3	3.7	1.7	1.8	1.8	-1.9	1.9
Lifetime Intake	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1
Liver weight, left	0.0	0.1	0.3	-0.1	-0.1	0.1	-0.0	0.5
Liver weight, right	1.6	2.8	4.8	2.2	2.0	1.9	-1.1	0.5
Locomotor activity	0.3	0.5	0.7	-0.8	-0.8	-0.7	0.6	-0.2
Locomotor testing distance	1.2	2.2	2.4	-1.5	-1.6	-1.5	1.6	-1.1
Locomotor testing rearing	0.7	1.3	1.6	-1.1	-1.3	-1.2	1.2	-0.9
Locomotion in novel chamber	0.5	0.7	1.2	-0.6	-0.7	-0.7	1.1	-0.9
Locomotion in novel chamber post-restriction	1.6	2.6	3.2	1.8	1.8	1.7	-1.7	0.8
Fecal boli incidents, locomotor time 1	0.4	0.5	0.8	-0.7	-0.7	-0.7	0.9	-0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	1.2	-0.3	0.0	0.0	-0.5	1.1
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.5	-0.3	-0.3	-0.4	0.5	-1.2
Bouts of movement, locomotor time 1	0.6	0.7	1.3	-1.1	-1.0	-0.9	0.6	-0.2
Total resting periods, locomotor time 1	0.5	0.5	1.1	-1.1	-0.8	-0.8	0.4	0.0
Rest time, locomotor task time 1	0.2	0.3	0.9	0.2	0.3	0.4	-0.6	0.9
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.3	0.1	0.2	0.0	-0.4
Vertical activity count, locomotor time 1	0.1	0.2	0.7	0.3	0.2	0.0	0.2	-0.8
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.2	0.4	0.3	0.4	-0.1	-0.1
Bouts of movement, locomotor time 2	0.7	1.1	1.6	-1.2	-1.1	-1.1	1.0	-0.7
Total resting periods, locomotor time 2	0.7	1.2	1.3	-1.1	-1.0	-1.1	1.1	-1.0
Rest time, locomotor task time 2	0.0	0.0	0.0	-0.0	0.1	0.1	0.0	-0.0
Distance moved, locomotor task time 2	0.0	0.0	0.0	0.2	-0.1	0.1	0.1	-0.1
Vertical activity count, locomotor time 2	0.2	0.3	0.7	-0.3	-0.4	-0.4	0.6	-0.8
Light reinforcement 1	0.2	0.4	1.7	0.2	-0.1	-0.2	0.5	-1.3
Light reinforcement 2	0.5	0.7	1.5	1.2	1.0	0.9	-0.4	-0.4
Bone: marrow area	0.4	0.9	1.2	-0.8	-0.9	-0.9	0.9	-1.1
Bone: maximum diameter	1.5	2.7	3.8	2.0	1.9	1.8	-1.4	0.9
Bone: maximum force	3.1	5.5	7.9	2.8	2.6	2.5	-2.3	1.2
Bone: maximum moment	4.2	7.3	9.7	3.1	2.9	2.8	-2.7	1.7
Mean time between licks in bursts	0.5	1.3	1.7	-1.3	-1.3	-1.2	1.1	-0.7
Mean num. licks in bursts	0.8	1.3	2.3	0.8	0.8	0.9	-1.4	1.5
Cd content in liver	2.1	2.3	3.0	-1.6	-1.7	-1.7	1.1	-1.4
Co content in liver	0.1	0.1	0.2	0.4	0.3	0.3	-0.5	0.3
Cu content in liver	2.4	2.8	3.3	1.6	1.7	1.6	-1.8	1.7
Fe content in liver	0.6	0.8	1.1	-0.9	-1.0	-1.0	0.7	-0.7
K content in liver	0.3	0.2	0.9	0.5	0.2	0.2	0.3	-0.9
Mg content in liver	1.5	1.5	4.0	-0.6	-0.9	-0.9	1.3	-2.0
Mn content in liver	0.1	0.1	0.1	0.3	0.3	0.3	0.1	-0.1
Na content in liver	0.3	0.3	0.7	-0.3	-0.4	-0.4	0.6	-0.8
Rb content in liver	0.1	0.2	0.6	0.3	0.1	0.0	0.1	-0.8
Se content in liver	0.0	0.0	0.0	0.1	0.1	0.0	-0.1	-0.2
Sr content in liver	0.6	0.5	1.4	0.4	0.6	0.6	-0.7	1.2
Zn content in liver	0.6	0.7	1.2	1.1	0.9	0.9	-0.6	0.0
Bone: minimum diameter	3.2	5.8	7.3	2.7	2.7	2.5	-2.3	1.8
Time in familiar zone, hab. session 1	0.1	0.1	0.3	-0.0	0.0	0.0	-0.3	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.1	-0.1	-0.1	0.2	-0.5
Total zone transitions, hab. session 1	0.7	1.0	1.3	-1.1	-1.2	-1.1	0.8	-0.8
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.5	-0.6	-0.7	0.4	-0.7
Locomotion velocity, hab. session 1	0.2	0.3	0.5	-0.5	-0.6	-0.6	0.4	-0.7
Time in familiar zone, hab. session 2	0.6	0.6	0.9	-0.9	-0.9	-0.9	0.6	-0.5
Time in novel zone, hab. session 2	0.0	0.0	0.0	0.1	0.1	0.1	0.2	-0.2
Total zone transitions, hab. session 2	2.4	3.1	4.1	-1.6	-1.7	-1.7	1.7	-2.0
Total locomotion distance, hab. session 2	1.1	1.5	3.4	-0.8	-1.0	-1.1	1.2	-1.8
Locomotion velocity, hab. session 2	0.7	1.0	2.7	-0.5	-0.7	-0.8	0.9	-1.7
Novel to familiar place preference ratio	3.6	3.9	4.5	1.9	2.1	1.9	-2.1	1.9
Novelty place preference	3.6	3.9	4.5	1.9	2.1	1.9	-2.1	1.9
Time in novel zone, NPP test	2.6	2.8	3.3	1.6	1.8	1.6	-1.8	1.6
Total zone transitions, NPP test	3.3	4.7	6.4	-1.9	-2.1	-2.1	2.2	-2.5
Total locomotion distance, NPP test	2.5	3.4	6.0	-1.4	-1.6	-1.7	1.9	-2.5
Locomotion velocity, NPP test	1.4	1.9	3.7	-1.0	-1.2	-1.3	1.4	-1.9
Intraocular pressure	0.0	0.1	0.1	0.3	0.3	0.2	-0.2	-0.1
Delta distance traveled before/after self-admin	1.1	1.1	1.3	-1.0	-1.1	-1.1	1.0	-1.1
Delta ambulatory time before/after self-admin	2.0	2.5	2.7	-1.6	-1.6	-1.6	1.7	-1.5
Parametrial fat weight	0.1	0.2	0.4	0.7	0.6	0.5	-0.4	-0.3
Pavlov. Cond. lever latency	3.9	4.9	5.9	-2.4	-2.4	-2.4	1.9	-1.9
Pavlov. Cond. magazine entry latency	4.1	5.3	5.5	2.3	2.2	2.3	-2.3	2.2
Pavlov. Cond. change in total contacts	2.1	2.3	3.6	1.2	1.4	1.4	-1.6	1.9
Pavlov. Cond. index score	4.9	6.2	7.5	2.7	2.6	2.7	-2.3	2.0
Pavlov. Cond. latency score	5.0	6.3	7.5	2.7	2.7	2.7	-2.3	2.1
Pavlov. Cond. lever contacts	2.1	2.5	3.1	1.8	1.7	1.8	-1.3	1.2
Pavlov. Cond. magazine entry number	5.9	7.4	8.0	-2.6	-2.6	-2.7	2.8	-2.8
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.0	-0.4	-0.4	-0.6	0.6	-1.0
Pavlov. Cond. lever-magazine prob. diff.	4.7	5.8	6.9	2.6	2.5	2.5	-2.3	2.0
Pavlov. Cond. response bias	4.6	5.7	6.0	2.4	2.4	2.5	-2.4	2.3
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.2	0.5	0.5	-0.3	0.9
Pavlov. Cond. magazine entry latency	3.5	4.2	5.2	-2.2	-2.3	-2.2	1.8	-1.7
Pavlov. Cond. change in total contacts	1.2	1.9	2.4	-1.4	-1.5	-1.6	1.1	-1.2
Pavlov. Cond. index score	1.1	1.4	1.9	-1.2	-1.4	-1.4	0.9	-1.0
Pavlov. Cond. latency score	1.2	1.6	2.0	-1.3	-1.4	-1.4	1.0	-1.1
Pavlov. Cond. lever contacts	0.3	0.4	1.0	-0.4	-0.6	-0.7	0.4	-1.0
Pavlov. Cond. magazine entry number	2.5	3.1	3.8	1.9	1.9	1.9	-1.6	1.4
Pavlov. Cond. intertrial magazine entries	0.4	0.6	1.2	1.1	0.9	0.9	-0.6	0.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.8	2.3	-1.4	-1.5	-1.5	1.0	-1.0
Pavlov. Cond. response bias	0.9	1.2	1.5	-1.0	-1.2	-1.2	0.8	-1.1
Time in closed arm before self-admin	0.2	0.2	0.7	0.0	0.2	0.2	-0.6	0.8
Time in closed arm after self-admin	0.1	0.1	0.3	-0.1	0.2	0.1	-0.2	0.5
Time in open arm before self-admin	0.4	0.5	1.3	0.0	-0.1	-0.2	1.0	-1.1
Time in open arm after self-admin	0.3	0.4	0.6	-0.4	-0.6	-0.6	0.7	-0.8
Bone: periosteal estimation	0.9	1.9	2.7	1.6	1.6	1.5	-1.3	0.6
Bone: periosteal perimeter	5.8	9.9	11.4	3.4	3.4	3.4	-3.0	2.6
Bone: post-yield work	0.2	0.3	0.5	-0.4	-0.6	-0.5	0.5	-0.7
Progressive ratio test 1 active lever presses	0.1	0.1	0.1	0.3	0.3	0.2	-0.4	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.2	0.4	0.4	0.3	-0.5	0.1
Progressive ratio test 1 inactive lever presses	0.3	0.5	1.0	1.0	0.8	0.7	-0.6	-0.2
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.0
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.2	0.3	0.2	-0.3	0.1
Progressive ratio test 2 inactive lever presses	0.3	0.5	0.5	0.7	0.6	0.7	-0.7	0.7
Incentive Sensitization - Responses	0.0	0.0	0.0	0.2	0.2	0.2	-0.2	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.1	0.2	0.2	0.2	-0.2	0.1
Sum of active levers in priming session hrs 5-6	1.3	1.2	2.7	0.5	0.6	0.5	-1.6	1.6
Progressive ratio	0.3	0.5	0.8	-0.9	-0.9	-0.8	0.7	-0.2
Food seeking constrained by brief footshock	0.3	0.3	1.0	0.2	0.3	0.3	-0.7	1.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	-0.1
Retroperitoneal fat weight	0.7	3.0	5.2	2.3	2.0	1.7	-1.6	0.2
Reaction time number correct	3.4	6.6	10.8	-2.0	-2.4	-2.4	2.5	-3.3
Reaction time mean minus median	0.1	0.3	0.4	0.4	0.5	0.6	-0.5	0.7
Reaction time mean minus median AUC	0.1	0.2	0.3	0.5	0.4	0.5	-0.2	0.1
Reaction time num false alarms	0.1	0.1	0.2	-0.5	-0.4	-0.4	0.3	0.0
Reaction time num false alarms AUC	0.3	0.5	0.7	-0.8	-0.8	-0.7	0.7	-0.4
Reaction time trials correct on left	3.4	6.6	10.8	-2.0	-2.4	-2.4	2.5	-3.3
Reaction time trials on left	3.6	6.8	11.1	-2.0	-2.4	-2.5	2.6	-3.3
Reaction time mean	0.0	0.0	0.0	0.2	0.2	0.1	-0.2	-0.2
Reaction time mean AUC	0.1	0.1	0.5	-0.1	-0.1	-0.2	0.2	-0.7
Median of all reaction times	0.0	0.0	0.2	0.0	-0.0	-0.1	-0.0	-0.5
Reaction time omissions	0.0	0.0	0.1	0.3	0.2	0.1	0.1	-0.3
Reaction time false alarm rate	0.4	0.5	1.8	0.2	0.5	0.5	-0.6	1.3
Reaction time premature initiation rate	0.8	1.1	1.8	-1.3	-1.2	-1.2	0.9	-0.2
Reaction time premature initiations	2.7	4.8	5.5	-2.2	-2.3	-2.3	2.1	-1.9
Std. dev. reaction times	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.5	-0.5
Reaction time trials completed	3.6	6.8	11.1	-2.0	-2.4	-2.5	2.6	-3.3
Reaction time trials AUC	3.5	6.7	11.1	-2.0	-2.4	-2.4	2.6	-3.3
Run reversals in cocaine runway, females	2.3	2.3	2.7	-1.6	-1.7	-1.6	1.3	-1.3
Run reversals in cocaine runway, males	3.0	3.0	3.4	1.7	1.8	1.7	-1.8	1.5
Latency to leave start box in cocaine runway	0.6	0.7	0.8	-0.9	-0.9	-0.8	0.8	-0.7
Latency to leave start box in cocaine runway, F	1.9	2.2	2.9	-1.2	-1.4	-1.4	1.7	-1.7
Latency to leave start box in cocaine runway, M	0.2	0.2	0.5	0.1	0.2	0.2	-0.6	0.7
Std. dev. time between licks in bursts	1.9	2.5	5.5	-1.1	-1.3	-1.4	1.5	-2.3
Total sessions with >9 infusions	0.1	0.2	0.3	-0.5	-0.3	-0.4	0.4	-0.3
Short access day 1 total inactive lever presses	0.2	0.3	0.7	-0.1	-0.3	-0.3	0.8	-0.7
Short access day 10 total inactive lever presses	0.5	1.1	2.0	1.4	1.1	1.1	-1.0	0.3
Short access day 1 total infusions	0.9	1.3	1.8	-1.3	-1.1	-1.2	1.1	-0.7
Short access day 10 total infusions	1.0	1.3	1.7	1.2	1.1	1.1	-1.3	0.9
Short access total infusions	0.0	0.0	0.1	-0.2	-0.1	-0.2	0.0	0.1
Short access day 1 locomotion	0.0	0.0	0.1	-0.1	0.0	0.0	-0.2	0.4
Short access day 10 total locomotion	0.6	1.0	1.8	0.7	1.0	0.9	-1.0	1.3
Short access total locomotion	0.6	0.7	1.0	0.6	0.9	0.8	-0.8	1.0
One hour access (0.3 mA shock)	0.0	0.0	0.1	-0.0	0.0	-0.1	-0.1	-0.3
Compulsive drug intake	0.2	0.2	0.8	-0.0	-0.2	-0.3	0.4	-0.9
One hour access (shock baseline)	0.0	0.0	0.0	0.2	0.1	0.1	0.1	-0.1
Social response proportion	0.6	0.7	0.8	-0.8	-0.9	-0.9	0.9	-0.7
Social responses	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.6	-0.6
Social time	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.5	-0.5
Soleus weight	0.8	2.5	4.0	2.0	1.7	1.8	-1.4	0.6
Bone: stiffness	0.2	0.3	0.5	0.7	0.6	0.6	-0.3	-0.1
Tibialis anterior weight	0.1	0.2	0.6	-0.3	-0.3	-0.4	0.3	-0.8
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.2	-0.2	-0.2	-0.1	0.4	-0.3
Time to tail flick, vehicle, after self-admin	0.8	1.0	2.1	-1.0	-0.9	-0.9	1.4	-0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.1	0.1	0.0	-0.0	0.3
Time to tail flick, test, after self-admin	0.1	0.1	0.3	-0.1	0.1	0.1	0.0	0.6
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.5	-0.3	-0.4	-0.4	0.7	-0.6
Delta time to tail flick, test, before/after SA	0.1	0.1	0.3	-0.1	0.1	0.1	-0.2	0.5
Tibia length	10.0	27.5	34.5	5.9	5.7	5.6	-5.0	3.8
Ambulatory time before self-admin	1.9	2.8	3.8	1.7	1.7	1.6	-1.9	1.4
Ambulatory time after self-admin	0.0	0.0	0.1	0.1	0.1	-0.0	-0.3	-0.1
Bone: tissue strength	0.5	0.6	1.0	1.0	0.8	0.8	-0.6	-0.0
Total heroin consumption	0.7	0.9	1.6	0.6	0.8	0.7	-1.0	1.3
Bone: trabecular number	0.0	0.0	0.1	0.2	0.3	0.3	-0.1	0.0
Bone: trabecular spacing	1.8	2.4	4.0	-1.2	-1.5	-1.6	1.5	-2.0
Bone: trabecular thickness	3.0	3.8	4.6	1.7	1.9	1.9	-2.0	2.2
Bone: trabecular tissue density	0.6	0.9	1.2	-1.0	-1.1	-0.9	1.0	-0.7
Water consumed over 24 hours	0.6	0.8	1.3	0.7	0.8	0.9	-0.8	1.1
Number of responses in last shaping day	0.0	0.0	0.0	0.2	0.2	0.2	0.2	-0.0