Hub : Genes

Axin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Axin2 0.06 0.03 7.1e-09 0.07 0.06 0.06 0.07 1.5e-10 1.3e-09 6.0e-10 2.3e-10
2 PL gene expression Axin2 0.15 0.06 1.7e-12 0.08 0.11 0.12 0.1 4.1e-09 8.2e-12 7.2e-13 1.9e-11
3 Brain gene expression Axin2 0.31 0.1 0.0e+00 0.25 0.27 0.28 0.24 4.0e-23 3.2e-25 1.4e-26 1.3e-22
4 NAcc alternative TSS XM_039085702.2 0.03 0.02 1.5e-03 0.02 0.02 0.01 0.01 7.3e-04 1.1e-03 9.8e-03 1.9e-03
5 IC gene expression Axin2 0.16 0.08 4.5e-06 0.11 0.16 0.13 0.15 2.6e-05 4.2e-07 4.0e-06 6.1e-07
6 IL gene expression Axin2 0.3 0.12 1.1e-05 0.1 0.15 0.08 0.11 2.4e-03 1.8e-04 6.6e-03 1.5e-03
7 NAcc alternative TSS XM_039085703.2 0.02 0.01 9.8e-03 0.01 0.01 0 0.01 2.0e-02 6.0e-03 7.8e-02 3.0e-02
8 Adipose gene expression Axin2 0.4 0.12 0.0e+00 0.18 0.2 0.2 0.2 2.7e-19 1.9e-21 2.0e-21 3.4e-22
9 NAcc alternative TSS XM_039085703.2 0.02 0.01 6.4e-03 0.01 0.01 0 0.01 1.4e-02 4.4e-03 6.8e-02 2.2e-02
10 BLA gene expression Axin2 0.09 0.05 3.4e-04 0.06 0.05 0.04 0.05 3.2e-04 1.5e-03 2.6e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density3.05.19.93.23.02.6-1.21.92.21.82.11.92.1
Area under the delay curve0.00.00.10.20.10.0-0.10.20.10.10.10.0-0.2
BMI with tail6.321.631.5-3.5-3.2-4.43.9-5.3-5.4-5.6-3.7-5.6-5.2
BMI without tail8.927.139.5-4.2-3.3-5.13.8-5.9-5.9-6.3-4.0-6.3-6.1
Body weight6.026.449.1-2.3-2.8-5.22.2-5.5-6.0-6.5-3.7-6.9-7.0
Weight adjusted by age3.04.56.8-1.8-2.3-2.61.3-2.0-2.3-2.0-2.5-2.1-2.1
Bone surface5.29.518.34.24.33.5-2.52.72.92.23.22.12.2
Bone volume4.47.816.04.04.03.3-2.12.32.51.83.01.72.0
Breakpoint value in progressive ratio session2.02.47.0-1.6-1.0-1.32.6-1.7-1.4-1.3-1.8-1.1-0.7
Number of licking bursts0.10.10.40.4-0.1-0.4-0.70.1-0.2-0.10.0-0.2-0.5
Context. condit. distance diff. score0.10.10.2-0.3-0.1-0.20.3-0.3-0.3-0.4-0.3-0.4-0.3
Locomotion velocity, session 10.00.00.1-0.00.30.30.1-0.10.0-0.2-0.1-0.10.1
Locomotion distance, session 10.10.20.3-0.20.60.30.6-0.5-0.2-0.50.0-0.4-0.1
Locomotion velocity, session 20.40.51.6-0.01.11.30.10.20.70.31.00.50.7
Locomotion distance, session 20.20.30.8-0.50.70.80.9-0.50.1-0.30.40.00.3
Locomotion velocity, session 31.31.53.4-1.9-0.3-0.71.7-1.6-1.1-1.3-0.8-1.0-1.0
Locomotion distance, session 30.10.10.80.40.90.4-0.20.10.30.10.40.20.1
Stereotopy head waving bouts, day 30.81.02.4-1.4-0.50.30.60.50.81.3-0.31.51.6
Stereotopy head waving duration, day 30.60.71.8-0.9-0.00.60.40.50.81.00.01.31.3
Locomotion velocity, session 70.10.10.90.0-0.00.40.9-0.3-0.0-0.1-0.0-0.00.3
Locomotion distance, session 70.30.41.30.80.91.0-0.50.30.4-0.01.1-0.00.0
Stereotopy head waving bouts, day 70.30.41.4-0.4-0.3-0.41.2-0.20.00.4-1.00.50.5
Stereotopy head waving duration, day 70.40.51.1-0.4-0.5-0.31.00.20.30.9-1.11.10.9
Locomotion velocity, session 80.10.10.2-0.4-0.10.5-0.30.30.30.30.00.30.4
Locomotion distance, session 80.20.20.7-0.40.80.70.4-0.40.1-0.40.6-0.20.1
Degree of sensitization distance0.20.21.00.20.20.9-0.50.40.40.11.00.10.3
Degree of sensitization stereotypy0.80.82.6-0.5-0.4-0.91.6-1.0-0.8-0.6-1.5-0.4-0.4
Conditioned locomotion0.50.61.10.71.01.0-0.30.60.80.60.90.70.7
Cocaine response after cond. corrected0.40.41.31.10.40.5-0.90.80.60.60.60.40.2
Cocaine response after cond. not corrected0.40.51.61.30.40.5-1.00.80.60.60.60.40.2
Cocaine response before conditioning0.00.10.1-0.20.20.3-0.30.20.30.20.20.20.2
Saline control response5.26.99.2-2.4-1.4-2.52.4-3.0-2.9-3.0-2.3-2.9-2.9
Bone: connectivity density4.06.39.82.73.13.0-1.12.22.62.32.32.52.7
Bone: cortical apparent density0.91.24.6-2.1-1.3-1.01.6-0.7-0.6-0.1-1.30.10.2
Bone: cortical area0.40.62.90.21.70.90.1-0.40.0-0.71.1-0.6-0.3
Bone: cortical porosity1.21.34.71.62.21.2-1.30.60.80.11.40.10.0
Bone: cortical porosity0.60.72.91.11.70.5-0.8-0.10.0-0.60.7-0.7-0.7
Bone: cortical thickness4.37.114.4-3.8-1.8-2.13.7-3.1-2.5-2.5-2.4-2.1-1.7
Bone: cortical thickness1.01.24.7-1.8-0.3-0.42.2-1.2-0.7-0.7-0.9-0.30.1
Bone: cortical tissue density0.91.34.5-2.1-1.4-1.01.6-0.7-0.6-0.1-1.40.10.2
Condit. Reinf. active minus inactive responses0.70.82.60.61.20.5-1.60.30.2-0.41.5-0.5-0.7
Condit. Reinf. active-inactive response ratio0.50.52.40.90.40.2-1.50.80.50.50.90.3-0.0
Condit. Reinf. active responses0.81.03.60.71.61.1-1.30.20.4-0.41.9-0.5-0.5
Condit. Reinf. inactive responses0.40.51.70.21.31.20.1-0.30.2-0.51.2-0.3-0.0
Incentive salience index mean0.30.41.10.30.90.2-0.8-0.2-0.1-0.61.1-0.6-0.8
Condit. Reinf. lever presses0.60.81.3-0.6-0.2-0.90.9-1.1-1.0-1.1-0.4-1.0-1.0
Condit. Reinf. active minus inactive responses2.73.58.82.33.02.0-2.31.31.50.62.60.60.3
Condit. Reinf. active-inactive response ratio2.63.06.22.52.41.7-2.31.41.40.82.20.70.4
Condit. Reinf. active responses2.63.79.82.23.12.4-2.21.11.50.42.80.30.3
Condit. Reinf. inactive responses0.50.62.1-0.21.51.4-0.1-0.10.5-0.31.3-0.10.2
Condit. Reinf. lever presses0.60.83.00.81.70.8-1.00.00.2-0.51.3-0.5-0.6
Condit. Reinf. lever reinforcers received2.33.28.32.22.92.2-2.11.01.30.32.70.30.2
Conditioned reinforcement - actives1.01.72.61.21.41.3-1.61.41.21.21.31.11.3
Conditioned reinforcement - inactives0.10.10.40.50.60.4-0.40.2-0.1-0.20.1-0.3-0.2
Conditioned locomotion0.40.51.41.20.90.4-1.20.20.0-0.30.6-0.5-0.7
Patch foraging indifference point 0 sec0.81.53.9-1.00.90.1-0.6-1.3-1.0-2.00.8-1.9-1.6
Patch foraging indifference point AUC0.10.20.5-0.40.0-0.2-0.3-0.3-0.4-0.60.2-0.6-0.7
Delay disc. indifference point, 0s delay0.10.10.30.5-0.1-0.50.10.2-0.00.3-0.40.1-0.2
Delay disc. indifference point, 16s delay0.20.30.6-0.3-0.7-0.60.2-0.4-0.5-0.5-0.4-0.6-0.8
Delay disc. indifference point, 2s delay0.40.40.70.70.50.4-0.80.70.80.70.70.60.1
Delay disc. indifference point, 24s delay0.20.20.60.70.80.50.0-0.1-0.1-0.40.4-0.5-0.4
Delay disc. indifference point, 4s delay0.00.00.10.10.2-0.00.10.30.30.40.20.30.2
Delay disc. indifference point, 8s delay0.30.30.8-0.6-0.8-0.70.7-0.3-0.4-0.1-0.9-0.1-0.3
Indifference point function ln k0.61.12.60.01.21.6-0.10.61.20.71.31.11.3
Indifference point function log k0.61.12.60.01.21.6-0.10.61.20.71.31.11.3
Patch foraging total patch changes 0 sec0.81.53.8-1.20.60.0-0.5-1.3-1.0-2.00.7-1.8-1.6
Patch foraging total patch changes 12 sec0.40.51.20.30.90.4-1.1-0.2-0.2-0.81.0-0.9-0.8
Patch foraging total patch changes 18 sec1.31.94.1-1.6-0.3-0.80.6-1.6-1.5-2.0-0.4-1.9-1.7
Patch foraging total patch changes 24 sec0.50.82.5-0.11.60.9-0.3-0.6-0.3-1.21.1-1.1-0.8
Patch foraging total patch changes 6 sec1.21.95.1-0.40.7-0.1-0.7-1.3-1.2-2.20.8-2.3-2.0
Patch foraging time to switch 0 sec0.20.41.10.4-0.9-0.90.5-0.2-0.6-0.2-1.1-0.4-0.3
Patch foraging water rate 0 sec0.20.51.5-0.40.90.5-1.0-0.30.0-0.61.2-0.5-0.7
Patch foraging water rate 12 sec0.51.01.7-1.3-0.6-0.80.5-1.2-1.1-1.3-0.7-1.2-1.0
Patch foraging water rate 18 sec0.10.20.8-0.30.50.60.9-0.40.1-0.20.20.10.4
Patch foraging water rate 24 sec0.20.30.8-0.10.80.90.10.20.60.40.70.60.6
Patch foraging water rate 6 sec0.10.10.6-0.80.10.10.6-0.30.1-0.10.30.1-0.0
Seeking ratio, delayed vs. immediate footshock0.91.13.2-0.7-0.9-1.10.2-1.0-1.1-1.2-0.5-1.3-1.8
Distance traveled before self-admin0.20.20.4-0.7-0.6-0.70.6-0.5-0.3-0.2-0.5-0.1-0.3
Distance traveled after self-admin0.00.00.10.10.2-0.20.3-0.20.0-0.20.0-0.20.0
Extensor digitorum longus weight3.112.019.4-1.9-4.1-4.43.1-3.2-3.8-2.9-4.4-3.1-3.1
Bone: elastic displacement0.40.51.5-1.0-0.4-0.31.2-0.9-0.4-0.5-0.8-0.3-0.3
Bone: elastic work1.01.42.4-0.6-0.3-1.11.3-1.5-1.2-1.4-1.1-1.2-1.3
Bone: endosteal estimation7.015.335.15.94.93.7-5.53.53.02.04.71.41.1
Bone: endosteal perimeter7.315.533.25.85.24.1-5.23.43.11.84.91.31.2
Epididymis fat weight5.418.426.1-2.6-4.0-5.12.6-4.2-5.0-4.5-4.3-4.8-5.0
Delta time in closed arm before/after self-admin1.61.52.21.20.71.1-0.81.41.31.51.01.41.5
Delta time in open arm before/after self-admin0.10.10.4-0.60.20.40.20.10.30.30.30.50.4
Diff in mean of infusions in LGA sessions2.22.65.1-1.6-1.6-1.62.3-1.7-1.6-1.3-2.0-1.3-0.9
Delay discount exponential model param0.10.10.2-0.5-0.3-0.20.4-0.3-0.3-0.2-0.3-0.10.2
Extinction: sum of active levers before priming0.91.02.8-0.1-0.3-0.81.7-1.2-1.1-1.1-0.9-1.1-0.8
Active lever presses in extinction session 60.20.20.90.30.5-0.00.9-0.4-0.3-0.4-0.4-0.3-0.1
Bone: final force0.71.13.31.31.81.0-0.90.80.80.61.20.50.6
Bone: final moment0.81.33.71.41.91.2-1.00.91.00.71.40.70.8
Food consumed during 24 hour testing period3.65.07.0-2.7-2.0-2.12.2-2.5-2.4-2.3-2.0-2.2-1.9
Glucose0.30.51.0-0.2-0.6-0.81.0-0.8-0.7-0.7-0.6-0.7-0.6
Heart weight0.71.12.70.30.1-0.60.5-1.2-1.1-1.5-0.6-1.6-1.7
Delay discount hyperbolic model param0.10.10.2-0.4-0.3-0.20.4-0.4-0.3-0.2-0.3-0.10.2
Intermittent access intake day 1-15 change0.20.41.61.0-0.3-0.4-1.30.4-0.3-0.1-0.5-0.5-0.9
Intermittent access intake escalation0.20.51.30.6-0.5-0.6-1.10.1-0.5-0.4-0.5-0.7-1.1
Intermittent access intake escalation 20.50.62.71.50.20.1-1.70.80.20.20.3-0.1-0.4
Intermitt. access day 1 inactive lever presses0.20.71.6-0.2-0.1-0.70.4-0.9-1.1-1.2-0.9-1.3-1.0
Intermitt. access day 15 inactive lever presses0.71.42.7-0.3-1.3-1.60.4-0.8-1.4-1.0-1.7-1.3-1.3
Intermitt. access escalation Index0.10.20.5-0.4-0.7-0.60.2-0.2-0.10.0-0.50.0-0.5
Intermittent access day 1 total infusions0.10.10.4-0.60.60.3-0.1-0.3-0.2-0.50.2-0.3-0.4
Intermittent access day 15 total infusions0.40.61.90.20.2-0.4-1.1-0.3-0.7-0.8-0.2-1.0-1.4
Intermittent access terminal intake (last 3 days)0.60.84.31.20.80.3-2.10.50.1-0.10.6-0.4-0.8
Intermittent access total infusions0.40.52.60.41.00.5-1.60.40.1-0.10.7-0.2-0.4
Intermittent access day 1 locomotion0.91.12.7-0.40.3-0.4-0.1-1.1-1.2-1.6-0.3-1.6-1.6
Intermittent access day 15 total locomotion0.30.51.20.71.10.5-0.6-0.2-0.4-0.80.5-0.9-0.8
Intermittent access total locomotion1.11.43.4-0.11.00.0-0.9-0.9-1.1-1.70.2-1.8-1.8
Intermittent access standard deviation0.20.52.31.30.2-0.2-1.50.5-0.3-0.2-0.2-0.5-0.4
Left kidney weight0.52.23.8-0.9-0.6-1.31.2-1.8-1.7-1.9-1.1-1.8-2.0
Right kidney weight0.73.15.1-0.6-0.6-1.81.5-2.0-2.0-2.0-1.6-2.1-2.3
Cocaine induced anxiety1.52.13.21.81.41.6-0.41.51.51.41.31.41.6
Post-drug Anxiety1.01.11.71.11.01.20.50.91.11.10.81.11.3
Baseline Anxiety0.70.91.6-1.3-1.0-1.11.2-0.8-0.7-0.4-1.1-0.4-0.7
Tail length0.93.49.1-1.0-0.5-1.9-0.4-1.8-2.0-2.4-0.7-2.5-3.0
Length with tail0.93.911.60.2-0.6-2.2-1.3-1.5-2.1-2.3-1.0-2.7-3.4
Length without tail0.51.74.00.7-0.8-1.6-0.4-0.8-1.5-1.3-1.3-1.7-2.0
Times rat made contact with spout0.60.71.4-0.6-0.6-0.90.2-0.9-1.0-1.0-0.7-1.0-1.2
Lifetime Intake0.30.31.4-0.10.80.4-1.2-0.0-0.1-0.50.5-0.4-0.6
Liver weight, left0.50.82.71.11.61.1-1.00.30.4-0.11.3-0.2-0.2
Liver weight, right1.32.22.8-1.5-1.3-1.61.6-1.6-1.6-1.4-1.7-1.4-1.2
Locomotor activity1.01.63.7-0.70.9-0.31.0-1.7-1.3-1.90.0-1.8-1.4
Locomotor testing distance1.22.14.6-0.80.8-0.51.4-2.0-1.5-2.2-0.1-2.0-1.7
Locomotor testing rearing1.83.66.8-1.5-0.3-1.31.6-2.5-2.1-2.6-0.8-2.4-2.3
Locomotion in novel chamber0.40.51.2-0.8-1.1-1.00.7-0.3-0.4-0.1-1.1-0.1-0.3
Locomotion in novel chamber post-restriction0.10.20.7-0.3-0.4-0.1-0.80.50.30.50.10.4-0.1
Fecal boli incidents, locomotor time 10.81.12.11.50.91.0-1.31.21.01.00.90.80.9
Change in fecal boli incidents, locomotor task0.30.30.60.30.00.2-0.60.70.60.80.20.70.4
Time >=10cm from walls, locomotor time 10.20.30.9-0.7-0.10.4-0.20.40.40.50.20.70.9
Bouts of movement, locomotor time 10.91.01.5-0.6-0.5-1.00.8-1.1-1.2-1.2-1.0-1.2-1.0
Total resting periods, locomotor time 10.40.50.9-0.1-0.5-0.80.5-0.7-0.9-0.7-0.9-0.8-0.7
Rest time, locomotor task time 10.20.20.40.6-0.5-0.3-0.30.50.10.6-0.50.40.2
Distance moved, locomotor task time 11.21.83.2-1.8-1.3-1.31.4-1.5-1.3-1.3-0.9-1.2-1.0
Vertical activity count, locomotor time 10.40.92.3-1.5-1.0-0.91.0-1.0-0.9-0.9-0.4-0.8-0.5
Time >=10cm from walls, locomotor time 22.84.15.9-2.3-2.4-2.32.2-1.9-2.0-1.6-2.3-1.5-1.3
Bouts of movement, locomotor time 23.75.97.9-2.4-1.9-2.02.6-2.8-2.7-2.7-2.4-2.6-2.0
Total resting periods, locomotor time 22.44.35.9-2.0-1.5-1.62.2-2.4-2.3-2.4-1.9-2.3-1.7
Rest time, locomotor task time 21.62.04.31.20.30.9-0.91.81.62.10.52.01.7
Distance moved, locomotor task time 25.26.28.1-2.8-2.7-2.72.7-2.5-2.5-2.2-2.4-2.1-1.9
Vertical activity count, locomotor time 22.43.44.2-2.0-1.5-1.91.7-2.0-2.0-2.0-1.4-2.0-1.6
Light reinforcement 10.92.34.8-1.9-0.6-0.92.2-2.0-1.4-1.7-0.7-1.4-1.3
Light reinforcement 20.20.30.9-0.4-0.3-0.80.4-0.7-0.6-0.5-0.4-0.5-0.9
Bone: marrow area6.814.934.25.94.83.6-5.43.53.02.04.61.41.2
Bone: maximum diameter3.97.313.23.33.62.9-3.22.52.41.73.31.51.4
Bone: maximum force1.11.96.81.92.61.5-1.30.80.90.41.80.30.5
Bone: maximum moment1.32.27.12.02.71.7-1.40.91.10.51.90.40.6
Mean time between licks in bursts0.61.52.60.3-1.1-1.40.6-1.1-1.5-1.4-1.2-1.6-1.5
Mean num. licks in bursts0.10.20.6-0.8-0.3-0.10.8-0.6-0.4-0.5-0.4-0.4-0.2
Cd content in liver0.80.91.90.8-1.40.1-0.51.10.61.3-0.31.11.1
Co content in liver0.40.51.40.0-0.8-1.10.7-0.5-0.7-0.4-1.2-0.4-0.5
Cu content in liver0.20.30.60.70.40.4-0.80.50.50.40.60.30.2
Fe content in liver0.60.72.20.61.51.2-0.70.50.70.41.10.50.4
K content in liver1.31.31.80.61.11.0-1.31.21.31.21.11.30.8
Mg content in liver2.02.13.70.91.11.3-0.81.51.71.81.11.91.7
Mn content in liver2.42.64.40.81.61.7-0.81.51.91.91.42.11.9
Na content in liver0.70.81.30.30.70.7-0.91.01.01.10.61.10.9
Rb content in liver0.70.81.8-0.10.20.4-0.91.11.01.30.51.31.0
Se content in liver0.00.10.3-0.60.2-0.00.0-0.00.20.20.00.30.1
Sr content in liver0.90.81.4-0.4-0.6-0.80.6-1.0-1.0-1.2-0.8-1.2-1.1
Zn content in liver0.80.91.21.01.01.1-0.80.91.00.81.10.90.7
Bone: minimum diameter3.97.217.04.14.12.7-3.61.81.70.53.50.10.1
Time in familiar zone, hab. session 10.60.61.91.10.30.7-1.40.90.60.40.70.20.2
Time in novel zone, hab. session 10.40.41.3-1.0-0.2-0.31.1-0.8-0.4-0.5-0.4-0.3-0.2
Total zone transitions, hab. session 11.62.23.6-0.9-0.6-1.31.7-1.9-1.7-1.9-1.1-1.8-1.6
Total locomotion distance, hab. session 11.21.83.1-1.3-0.3-0.91.7-1.8-1.4-1.6-0.9-1.4-1.3
Locomotion velocity, hab. session 11.21.72.9-1.3-0.5-1.11.6-1.7-1.4-1.6-0.9-1.4-1.3
Time in familiar zone, hab. session 20.30.30.80.70.70.6-0.90.40.3-0.00.9-0.1-0.1
Time in novel zone, hab. session 20.30.30.9-0.4-0.30.20.40.40.50.8-0.11.00.9
Total zone transitions, hab. session 22.93.75.6-1.5-1.1-1.62.3-2.4-2.0-2.2-1.8-2.0-1.8
Total locomotion distance, hab. session 23.03.96.0-2.2-1.6-1.72.4-2.3-2.0-2.0-1.8-1.8-1.5
Locomotion velocity, hab. session 22.63.55.8-2.2-1.6-1.62.4-2.2-1.8-1.8-1.8-1.6-1.3
Novel to familiar place preference ratio0.60.72.11.41.20.5-1.20.30.2-0.20.9-0.4-0.5
Novelty place preference0.40.51.61.31.10.4-0.90.20.1-0.20.7-0.4-0.5
Time in novel zone, NPP test0.50.51.71.21.30.6-0.80.30.2-0.20.9-0.3-0.3
Total zone transitions, NPP test0.81.23.5-1.50.3-0.11.9-1.5-0.9-1.3-0.4-1.0-0.5
Total locomotion distance, NPP test0.81.13.6-1.9-0.3-0.21.8-1.4-0.8-1.1-0.4-0.7-0.4
Locomotion velocity, NPP test1.42.04.7-2.2-0.7-0.72.0-1.8-1.3-1.5-0.8-1.2-0.8
Intraocular pressure0.40.61.8-0.30.20.00.7-1.1-0.7-1.30.1-1.2-0.9
Delta distance traveled before/after self-admin0.10.10.3-0.20.40.10.5-0.4-0.2-0.50.2-0.4-0.1
Delta ambulatory time before/after self-admin0.40.51.61.21.30.8-0.30.50.60.20.80.20.5
Parametrial fat weight0.92.03.81.3-0.00.8-1.51.91.52.00.71.81.5
Pavlov. Cond. lever latency3.44.37.91.20.62.1-1.42.42.32.61.32.62.8
Pavlov. Cond. magazine entry latency0.20.30.70.20.6-0.4-0.3-0.4-0.5-0.70.3-0.8-0.9
Pavlov. Cond. change in total contacts1.51.53.9-0.20.2-1.20.4-1.4-1.4-1.7-0.4-1.7-2.0
Pavlov. Cond. index score0.91.12.7-0.20.3-1.00.3-1.2-1.2-1.5-0.2-1.5-1.7
Pavlov. Cond. latency score1.51.94.5-0.40.0-1.40.6-1.6-1.6-1.9-0.5-1.9-2.1
Pavlov. Cond. lever contacts3.03.66.3-0.8-0.7-2.11.3-2.2-2.2-2.3-1.4-2.3-2.5
Pavlov. Cond. magazine entry number0.20.20.5-0.4-0.70.30.40.20.30.5-0.40.60.6
Pavlov. Cond. intertrial magazine entries0.60.82.00.51.41.0-1.0-0.20.1-0.81.2-0.8-0.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.1-0.00.6-0.70.3-1.1-1.0-1.30.1-1.4-1.4
Pavlov. Cond. response bias0.30.30.90.10.6-0.6-0.2-0.5-0.6-0.70.1-0.8-1.0
Pavlov. Cond. lever latency1.21.64.1-1.2-2.0-1.71.3-1.0-1.2-0.7-1.5-0.7-0.7
Pavlov. Cond. magazine entry latency0.10.20.40.10.20.6-0.20.40.40.40.40.40.6
Pavlov. Cond. change in total contacts0.81.32.71.31.61.6-1.00.91.10.61.50.60.7
Pavlov. Cond. index score1.01.43.21.31.81.6-1.10.91.00.61.40.60.8
Pavlov. Cond. latency score1.01.43.01.11.71.6-1.21.01.10.71.40.70.8
Pavlov. Cond. lever contacts0.91.23.71.01.91.6-0.90.71.00.51.30.60.7
Pavlov. Cond. magazine entry number0.00.00.10.1-0.1-0.3-0.3-0.0-0.1-0.1-0.0-0.1-0.3
Pavlov. Cond. intertrial magazine entries0.20.21.00.51.00.6-0.50.20.30.00.70.00.1
Pavlov. Cond. lever-magazine prob. diff.1.11.43.01.21.71.6-1.11.01.10.71.50.70.8
Pavlov. Cond. response bias1.11.43.71.21.91.6-1.00.91.10.71.40.70.8
Time in closed arm before self-admin2.22.84.6-2.1-1.0-1.61.6-2.0-1.6-1.9-1.2-1.8-1.7
Time in closed arm after self-admin1.51.72.6-1.3-1.5-1.61.2-1.2-1.3-1.1-1.3-1.2-1.1
Time in open arm before self-admin0.70.81.4-0.1-1.2-1.10.3-0.6-1.1-0.8-1.2-0.9-0.7
Time in open arm after self-admin0.00.00.20.20.10.2-0.5-0.0-0.1-0.20.2-0.2-0.2
Bone: periosteal estimation4.49.320.04.24.53.2-3.92.42.31.14.00.80.8
Bone: periosteal perimeter2.95.011.53.33.42.3-2.71.61.50.63.00.30.5
Bone: post-yield work0.91.34.62.21.91.0-1.20.60.40.01.2-0.2-0.0
Progressive ratio test 1 active lever presses1.92.44.3-1.7-0.6-1.30.2-1.7-1.7-2.0-1.0-1.9-2.1
Progressive ratio test 1 breakpoint1.72.13.9-1.5-0.5-1.10.1-1.6-1.6-1.9-0.9-1.8-2.0
Progressive ratio test 1 inactive lever presses1.42.04.2-0.8-0.0-1.1-0.2-1.5-1.6-2.0-0.8-2.0-2.0
Progressive ratio test 2 active lever presses0.20.20.6-0.50.2-0.3-0.7-0.3-0.4-0.5-0.1-0.5-0.8
Progressive ratio test 2 breakpoint0.20.20.6-0.50.1-0.3-0.7-0.3-0.4-0.5-0.2-0.5-0.8
Progressive ratio test 2 inactive lever presses0.20.40.8-0.5-0.1-0.5-0.0-0.5-0.8-0.7-0.6-0.8-0.9
Incentive Sensitization - Responses0.10.20.80.30.30.2-0.90.50.40.40.50.3-0.1
Incentive Sensitization - Breakpoint0.20.31.00.40.30.3-1.00.60.50.50.50.4-0.0
Sum of active levers in priming session hrs 5-61.01.02.0-1.0-1.0-1.01.4-1.0-0.9-0.8-1.2-0.7-0.5
Progressive ratio0.10.20.50.7-0.00.2-0.60.60.40.60.10.40.5
Food seeking constrained by brief footshock0.30.41.41.20.50.2-1.00.60.50.40.60.40.3
Seeking ratio, punishment vs. effort0.10.20.4-0.40.3-0.00.2-0.5-0.3-0.60.3-0.5-0.5
Retroperitoneal fat weight3.113.017.4-2.2-3.5-4.22.5-3.6-4.2-3.8-3.5-4.0-4.1
Reaction time number correct0.40.81.30.60.91.0-0.30.81.11.00.91.10.9
Reaction time mean minus median0.30.72.30.0-1.5-1.4-0.30.0-0.50.1-1.4-0.1-0.5
Reaction time mean minus median AUC0.30.71.40.7-0.10.2-1.21.10.91.20.01.10.7
Reaction time num false alarms0.71.03.40.51.81.1-0.2-0.5-0.1-1.11.5-1.0-0.7
Reaction time num false alarms AUC0.71.14.10.82.01.3-0.5-0.10.2-0.71.7-0.7-0.4
Reaction time trials correct on left0.40.81.30.60.91.0-0.30.81.11.00.91.10.9
Reaction time trials on left0.50.91.40.70.91.0-0.40.91.21.10.91.20.9
Reaction time mean0.71.02.30.6-0.30.2-1.31.41.01.5-0.11.41.1
Reaction time mean AUC0.50.81.80.3-0.5-0.1-1.01.20.71.3-0.41.20.9
Median of all reaction times1.11.53.20.60.10.7-1.31.61.31.80.41.71.5
Reaction time omissions0.20.20.60.8-0.30.1-0.60.60.30.6-0.40.50.4
Reaction time false alarm rate0.50.71.50.31.20.6-0.2-0.6-0.5-1.20.9-1.2-0.8
Reaction time premature initiation rate0.40.61.70.10.6-0.00.1-0.8-0.7-1.20.3-1.3-1.1
Reaction time premature initiations0.20.41.50.71.20.8-0.30.00.2-0.31.0-0.3-0.2
Std. dev. reaction times0.40.81.60.6-0.9-0.3-1.21.20.61.3-0.61.00.8
Reaction time trials completed0.50.91.40.70.91.0-0.40.91.21.10.91.20.9
Reaction time trials AUC0.40.81.40.60.81.0-0.40.91.11.10.91.21.0
Run reversals in cocaine runway, females7.67.69.7-1.8-2.9-3.02.9-2.7-3.1-2.5-3.1-2.7-2.5
Run reversals in cocaine runway, males0.20.20.40.6-0.10.1-0.50.60.50.60.10.50.4
Latency to leave start box in cocaine runway2.42.89.2-3.0-1.8-1.42.1-1.6-1.3-1.2-1.2-0.9-0.7
Latency to leave start box in cocaine runway, F4.04.510.0-3.2-1.9-1.82.7-2.4-2.0-2.1-1.5-1.8-1.4
Latency to leave start box in cocaine runway, M0.40.31.8-1.3-0.8-0.50.4-0.1-0.00.3-0.50.40.2
Std. dev. time between licks in bursts1.01.42.8-1.0-1.4-1.21.7-1.2-1.2-0.9-1.3-0.8-0.7
Total sessions with >9 infusions1.21.53.3-1.8-0.7-1.10.1-1.3-1.3-1.4-0.9-1.3-1.5
Short access day 1 total inactive lever presses0.10.10.3-0.50.4-0.0-0.6-0.1-0.1-0.2-0.1-0.2-0.2
Short access day 10 total inactive lever presses0.00.10.20.4-0.2-0.2-0.20.2-0.10.1-0.4-0.00.1
Short access day 1 total infusions0.71.03.0-1.7-0.1-0.50.5-1.2-0.8-1.2-0.2-1.0-1.2
Short access day 10 total infusions1.11.53.6-1.10.1-0.7-0.2-1.3-1.3-1.7-0.3-1.7-1.9
Short access total infusions0.30.30.7-0.90.50.1-0.5-0.6-0.4-0.80.2-0.6-0.8
Short access day 1 locomotion3.64.57.1-2.2-0.9-1.71.6-2.5-2.3-2.7-1.4-2.5-2.6
Short access day 10 total locomotion0.81.53.9-0.3-0.2-0.9-0.3-1.1-1.4-1.7-0.7-1.8-2.0
Short access total locomotion3.13.86.8-1.7-1.0-1.60.7-2.1-2.3-2.5-1.4-2.5-2.6
One hour access (0.3 mA shock)1.11.33.81.21.61.3-1.90.90.80.51.20.40.3
Compulsive drug intake2.12.54.72.01.61.4-2.21.61.61.31.91.20.6
One hour access (shock baseline)0.00.10.1-0.00.20.1-0.3-0.1-0.3-0.3-0.1-0.4-0.2
Social response proportion0.30.42.41.60.60.3-0.60.50.40.30.30.10.3
Social responses0.30.30.80.30.80.30.3-0.6-0.5-0.90.3-0.9-0.5
Social time0.40.53.41.80.20.3-0.60.70.40.50.10.20.1
Soleus weight0.31.02.10.70.2-1.00.4-1.0-1.1-1.2-0.6-1.4-1.4
Bone: stiffness0.71.13.11.41.81.0-1.00.80.80.51.40.40.6
Tibialis anterior weight2.27.310.7-0.6-2.0-3.32.3-2.9-3.1-2.9-2.7-3.0-3.1
Time to tail flick, vehicle, before self-admin0.70.71.61.2-0.20.3-1.31.20.61.10.00.90.5
Time to tail flick, vehicle, after self-admin0.71.01.91.40.90.7-1.11.21.01.10.81.00.4
Time to tail flick, test, before self-admin0.60.62.81.70.70.4-0.90.50.50.21.00.0-0.4
Time to tail flick, test, after self-admin0.50.61.61.00.70.7-1.20.70.60.40.90.30.4
Delta time to tail flick, vehicle, before/after SA1.11.11.51.01.11.0-1.01.11.21.01.21.00.7
Delta time to tail flick, test, before/after SA1.01.12.30.50.50.9-1.51.21.01.10.81.01.2
Tibia length0.72.04.2-0.5-0.6-2.0-0.1-1.3-1.7-1.5-1.4-1.7-2.1
Ambulatory time before self-admin0.40.61.5-1.2-1.1-1.00.8-0.7-0.5-0.4-0.8-0.3-0.4
Ambulatory time after self-admin0.10.10.7-0.20.2-0.30.8-0.5-0.1-0.3-0.0-0.30.0
Bone: tissue strength0.10.10.4-0.60.30.40.4-0.10.30.20.10.40.5
Total heroin consumption0.10.10.40.10.60.30.00.10.10.2-0.10.20.3
Bone: trabecular number3.76.19.62.73.12.9-1.32.22.62.32.42.42.5
Bone: trabecular spacing1.82.44.9-1.8-2.2-1.81.0-1.3-1.6-1.3-1.6-1.4-1.3
Bone: trabecular thickness1.92.45.11.82.32.0-1.31.21.40.92.00.91.0
Bone: trabecular tissue density0.40.52.0-1.4-1.1-0.80.5-0.3-0.5-0.2-0.9-0.2-0.1
Water consumed over 24 hours1.82.44.6-2.1-1.4-1.42.0-1.7-1.6-1.4-1.4-1.2-0.9
Number of responses in last shaping day1.92.03.3-1.4-1.8-1.80.7-1.1-1.5-1.2-1.8-1.3-1.2