Axin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	IL	isoform ratio	XM_039085704.1	0.18	0.1	2.5e-03	0.02	0.1	0.06	0.06	9.8e-02	2.0e-03	1.2e-02	1.8e-02
2	IL	alternative TSS	XM_039085704.1	0.17	0.11	5.9e-03	0.11	0.09	0.08	0.09	1.7e-03	3.1e-03	6.4e-03	3.5e-03
3	NAcc	gene expression	Axin2	0.06	0.04	9.2e-05	0.04	0.03	0.03	0.03	4.7e-05	3.5e-04	1.6e-04	1.8e-04
4	PL	gene expression	Axin2	0.15	0.06	4.0e-14	0.11	0.13	0.13	0.13	7.6e-12	3.9e-14	1.5e-14	3.7e-14
5	IL	isoform ratio	XM_039085700.1	0.26	0.15	2.1e-03	0.14	0.1	0.1	0.11	3.1e-04	2.5e-03	1.7e-03	1.4e-03
6	IL	gene expression	Axin2	0.29	0.11	1.2e-05	0.07	0.16	0.11	0.1	7.3e-03	1.1e-04	1.5e-03	1.9e-03
7	Brain	gene expression	Axin2	0.29	0.1	0.0e+00	0.24	0.26	0.25	0.25	2.4e-22	6.0e-24	2.7e-23	5.2e-23
8	BLA	gene expression	Axin2	0.09	0.05	2.5e-04	0.03	0.03	0.05	0.04	1.3e-02	6.4e-03	1.3e-03	5.0e-03
9	Adipose	gene expression	Axin2	0.44	0.13	0.0e+00	0.17	0.2	0.2	0.2	8.1e-19	1.1e-21	2.4e-22	2.2e-21

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	2.0	3.4	7.3	-0.9	1.4	-2.7	-2.5	-1.0	2.0	2.0	-2.1	-1.1
Area under the delay curve	0.2	0.2	0.6	-0.8	0.6	-0.4	-0.3	-0.3	0.2	0.1	0.1	0.5
BMI with tail	5.4	17.6	27.9	1.1	-4.4	3.8	4.1	4.7	-5.3	-4.8	5.2	2.7
BMI without tail	2.7	5.6	10.9	0.3	-2.5	2.4	1.9	2.7	-3.1	-2.6	3.3	0.2
Body weight	3.8	16.1	37.1	-0.7	-3.5	3.1	3.7	3.4	-5.2	-5.2	6.1	2.6
Weight adjusted by age	3.7	4.2	6.2	0.7	-1.9	1.9	2.4	1.8	-2.3	-2.5	2.4	1.9
Bone surface	4.6	8.2	15.2	-2.7	2.9	-3.9	-3.7	-2.4	2.9	2.7	-2.4	-1.1
Bone volume	4.0	6.9	12.6	-2.7	2.6	-3.6	-3.5	-2.1	2.5	2.5	-2.1	-1.3
Breakpoint value in progressive ratio session	1.7	1.8	3.7	1.4	-1.9	1.3	1.2	1.9	-1.5	-1.0	1.1	0.0
Number of licking bursts	0.3	0.4	0.8	-0.9	0.8	-0.3	-0.1	-0.6	-0.1	-0.5	0.7	0.8
Context. condit. distance diff. score	0.1	0.1	0.3	-0.3	-0.5	0.0	0.1	0.4	-0.3	-0.3	0.3	0.4
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	-0.2	0.1	-0.0	0.1	-0.0	0.2	-0.0	-0.2
Locomotion distance, session 1	0.3	0.4	1.7	0.4	-0.7	0.4	-0.2	0.7	-0.2	0.4	-0.2	-1.3
Locomotion velocity, session 2	0.6	0.8	2.4	0.8	0.0	0.3	-0.9	0.0	0.6	1.3	-0.9	-1.5
Locomotion distance, session 2	0.6	0.9	3.2	1.3	-0.7	0.6	-0.5	0.9	0.0	0.9	-0.6	-1.8
Locomotion velocity, session 3	1.7	2.0	4.3	2.1	-1.6	2.1	1.1	1.7	-1.3	-0.6	1.1	-0.4
Locomotion distance, session 3	0.2	0.2	0.6	-0.2	0.5	-0.3	-0.8	-0.3	0.4	0.5	-0.1	-0.3
Stereotopy head waving bouts, day 3	1.1	1.3	6.7	2.6	-0.7	1.4	0.5	0.8	0.3	0.6	-1.1	0.3
Stereotopy head waving duration, day 3	0.6	0.7	3.0	1.7	-0.2	0.9	0.0	0.4	0.5	0.8	-1.1	0.2
Locomotion velocity, session 7	0.2	0.2	0.6	0.6	-0.3	-0.0	-0.1	0.8	-0.1	0.3	-0.6	-0.7
Locomotion distance, session 7	0.8	1.0	2.4	-1.1	1.0	-1.1	-1.3	-0.6	0.7	0.8	-0.7	-1.5
Stereotopy head waving bouts, day 7	0.9	1.0	4.0	2.0	-1.4	0.6	0.6	1.3	-0.5	-0.3	0.2	0.0
Stereotopy head waving duration, day 7	0.8	1.0	5.9	2.4	-1.2	0.7	0.6	1.0	-0.1	-0.0	-0.2	0.4
Locomotion velocity, session 8	0.1	0.1	0.4	-0.2	0.3	0.2	-0.3	-0.3	0.4	0.6	-0.6	0.0
Locomotion distance, session 8	0.3	0.4	1.6	0.4	-0.6	0.3	-0.6	0.5	0.1	0.8	-0.5	-1.3
Degree of sensitization distance	0.5	0.5	1.7	-0.7	0.5	-0.4	-0.5	-0.5	0.6	0.7	-0.9	-1.3
Degree of sensitization stereotypy	1.0	1.1	2.6	1.6	-1.6	0.6	0.7	1.5	-0.9	-0.7	0.8	0.1
Conditioned locomotion	0.3	0.4	0.8	-0.1	0.5	-0.5	-0.7	-0.3	0.7	0.9	-0.9	-0.7
Cocaine response after cond. corrected	0.7	0.8	1.7	-1.3	1.3	-1.1	-0.6	-1.0	0.7	0.3	-0.5	0.4
Cocaine response after cond. not corrected	0.9	1.0	2.2	-1.5	1.4	-1.3	-0.8	-1.2	0.8	0.3	-0.3	0.4
Cocaine response before conditioning	0.1	0.1	0.2	0.1	0.3	0.1	-0.4	-0.3	0.3	0.4	-0.1	-0.3
Saline control response	3.2	4.2	7.2	1.0	-2.3	2.2	2.0	2.2	-2.6	-2.1	2.7	0.5
Bone: connectivity density	2.6	4.1	7.4	0.1	1.2	-2.4	-2.5	-0.9	2.4	2.6	-2.7	-1.5
Bone: cortical apparent density	1.7	2.2	5.5	2.4	-1.6	2.3	1.4	1.5	-1.0	-0.7	0.4	0.3
Bone: cortical area	0.3	0.4	1.4	-0.8	0.2	0.2	-1.2	0.1	-0.1	0.6	0.4	-1.1
Bone: cortical porosity	1.3	1.4	3.2	-1.8	1.2	-1.3	-1.6	-1.1	0.8	0.9	-0.1	-0.8
Bone: cortical porosity	0.8	0.9	3.7	-1.9	1.0	-1.0	-1.3	-0.7	0.3	0.4	0.5	-0.3
Bone: cortical thickness	5.5	9.1	17.7	3.5	-3.6	4.2	2.4	3.8	-3.1	-1.9	2.4	-0.0
Bone: cortical thickness	1.8	2.1	6.3	2.5	-1.8	1.9	0.8	2.0	-1.0	-0.2	0.3	-0.1
Bone: cortical tissue density	1.6	2.2	5.4	2.3	-1.6	2.3	1.5	1.5	-1.1	-0.7	0.4	0.3
Condit. Reinf. active minus inactive responses	1.2	1.3	4.5	-2.1	1.3	-0.6	-1.2	-1.4	0.5	0.5	0.2	-1.3
Condit. Reinf. active-inactive response ratio	0.8	0.9	2.3	-1.5	1.3	-1.0	-0.8	-1.4	0.7	0.2	-0.1	-0.3
Condit. Reinf. active responses	1.4	1.7	4.6	-1.9	1.2	-0.7	-1.6	-1.1	0.7	1.0	-0.1	-2.1
Condit. Reinf. inactive responses	0.6	0.8	4.4	-0.2	0.2	-0.2	-1.0	0.1	0.3	1.0	-0.5	-2.1
Incentive salience index mean	0.5	0.6	1.8	-1.2	0.6	-0.3	-0.9	-0.6	0.1	0.2	0.5	-1.3
Condit. Reinf. lever presses	0.5	0.7	1.5	0.5	-1.0	0.7	0.4	1.0	-1.1	-0.8	1.2	-0.6
Condit. Reinf. active minus inactive responses	3.7	4.5	7.9	-2.6	2.5	-2.2	-2.8	-2.3	1.9	2.0	-0.9	-1.3
Condit. Reinf. active-inactive response ratio	3.7	3.9	6.8	-2.6	2.4	-2.4	-2.3	-2.2	1.7	1.5	-0.9	-0.7
Condit. Reinf. active responses	3.7	5.1	9.4	-2.7	2.4	-2.2	-3.1	-2.2	1.9	2.3	-1.0	-1.9
Condit. Reinf. inactive responses	0.8	1.0	3.6	-0.2	0.3	0.1	-1.4	-0.2	0.6	1.5	-0.5	-1.9
Condit. Reinf. lever presses	0.6	0.8	2.2	-1.5	0.9	-0.6	-1.3	-0.8	0.2	0.6	0.6	-1.0
Condit. Reinf. lever reinforcers received	3.2	4.5	7.9	-2.7	2.3	-2.1	-2.8	-2.1	1.8	2.1	-0.9	-1.8
Conditioned reinforcement - actives	1.0	1.0	2.6	0.6	0.9	-0.6	-0.7	-0.9	1.3	1.3	-1.6	0.0
Conditioned reinforcement - inactives	0.1	0.1	0.5	-0.5	0.2	-0.2	-0.3	-0.6	0.1	0.1	-0.0	0.7
Conditioned locomotion	1.4	1.7	3.6	-1.9	1.5	-1.6	-1.4	-1.6	1.1	0.9	-0.4	-0.8
Patch foraging indifference point 0 sec	0.4	0.6	1.7	-1.3	0.3	0.9	-0.3	-0.6	-0.6	0.1	1.1	-0.9
Patch foraging indifference point AUC	0.3	0.3	0.8	-0.9	0.8	0.0	-0.6	-0.5	0.2	0.2	0.1	0.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.8	-0.5	0.2	-0.9	0.0	-0.1	0.1	-0.3	0.2	0.6
Delay disc. indifference point, 16s delay	0.3	0.3	0.6	-0.5	0.0	0.2	0.6	0.2	-0.5	-0.7	0.8	0.7
Delay disc. indifference point, 2s delay	0.6	0.6	1.1	-0.8	1.1	-0.8	-0.8	-0.9	0.9	0.7	-0.2	-0.4
Delay disc. indifference point, 24s delay	0.2	0.2	1.0	-1.0	0.3	-0.7	-0.7	-0.2	0.0	0.1	0.1	0.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.4	-0.4	0.6	-0.3	-0.3	-0.3	0.4	0.2	-0.1	0.1
Delay disc. indifference point, 8s delay	0.5	0.5	1.3	0.6	-0.5	0.8	0.8	0.5	-0.5	-0.7	0.5	1.2
Indifference point function ln k	1.0	1.4	5.2	1.0	-0.0	0.0	-0.9	-0.0	0.9	1.7	-1.3	-2.3
Indifference point function log k	1.0	1.4	5.2	1.0	-0.0	0.0	-0.9	-0.0	0.9	1.7	-1.3	-2.3
Patch foraging total patch changes 0 sec	0.3	0.5	1.2	-1.1	0.2	1.1	-0.1	-0.5	-0.6	0.1	1.1	-0.8
Patch foraging total patch changes 12 sec	0.6	0.8	3.6	-1.9	1.0	-0.3	-0.7	-1.4	0.2	0.4	0.3	-0.4
Patch foraging total patch changes 18 sec	0.6	0.8	2.5	-0.4	-0.3	1.6	0.5	0.4	-1.2	-0.7	1.3	0.7
Patch foraging total patch changes 24 sec	0.5	0.6	1.9	-1.4	0.5	0.1	-1.0	-0.4	-0.0	0.6	0.2	-1.2
Patch foraging total patch changes 6 sec	0.7	1.0	5.2	-2.3	0.8	0.2	-0.4	-0.7	-0.6	-0.2	1.2	0.3
Patch foraging time to switch 0 sec	0.2	0.3	1.1	-0.4	-0.4	-0.4	0.7	0.2	-0.5	-1.1	0.6	0.3
Patch foraging water rate 0 sec	0.1	0.2	0.4	-0.6	0.6	0.5	-0.5	-0.3	0.1	0.5	0.3	-0.1
Patch foraging water rate 12 sec	0.7	1.1	2.6	0.8	-1.1	1.6	1.0	0.9	-1.1	-0.7	1.1	0.6
Patch foraging water rate 18 sec	0.4	0.6	1.6	1.2	-1.0	0.5	0.0	1.3	-0.3	0.4	-0.4	-0.7
Patch foraging water rate 24 sec	0.3	0.4	0.9	0.9	0.1	0.1	-0.4	0.4	0.5	1.0	-0.8	-0.5
Patch foraging water rate 6 sec	0.3	0.4	1.4	1.2	-0.5	1.0	0.3	1.0	-0.2	0.3	0.0	0.0
Seeking ratio, delayed vs. immediate footshock	0.8	0.9	2.8	-0.7	0.0	1.0	0.8	0.3	-1.0	-1.2	1.7	1.1
Distance traveled before self-admin	0.1	0.1	0.2	-0.3	0.1	-0.0	0.2	0.0	0.2	-0.0	0.4	-0.5
Distance traveled after self-admin	0.1	0.1	0.6	-0.2	0.0	-0.0	-0.0	0.5	-0.1	-0.1	0.3	-0.7
Extensor digitorum longus weight	2.8	10.8	20.8	1.3	-2.8	2.0	4.0	3.2	-4.0	-4.6	3.5	3.0
Bone: elastic displacement	0.7	0.8	3.1	1.8	-1.2	0.9	0.5	1.2	-0.5	0.0	0.1	-0.5
Bone: elastic work	0.8	1.0	1.9	1.1	-1.3	0.7	0.8	1.4	-1.2	-0.8	1.1	0.5
Bone: endosteal estimation	9.6	20.9	48.1	-6.9	5.6	-5.6	-4.9	-5.2	3.7	2.8	-1.9	-0.9
Bone: endosteal perimeter	10.3	21.3	45.9	-6.8	5.5	-5.7	-5.3	-5.0	3.8	3.2	-2.1	-1.1
Epididymis fat weight	7.0	16.3	32.1	0.1	-3.3	2.9	4.8	3.4	-5.0	-5.7	5.2	3.0
Delta time in closed arm before/after self-admin	1.8	1.8	2.9	-0.8	1.3	-1.7	-1.4	-1.2	1.6	1.3	-1.6	-0.6
Delta time in open arm before/after self-admin	0.6	0.6	2.1	1.5	-0.4	0.6	0.1	0.5	0.4	0.7	-0.7	-1.0
Diff in mean of infusions in LGA sessions	2.1	2.3	3.8	0.7	-1.7	1.1	1.5	2.0	-1.8	-1.8	1.5	1.2
Delay discount exponential model param	0.4	0.4	1.3	1.1	-0.9	0.7	0.5	0.7	-0.5	-0.2	0.0	-0.4
Extinction: sum of active levers before priming	0.2	0.2	1.2	-0.1	-0.3	-0.2	0.0	1.1	-0.5	-0.4	0.3	-0.6
Active lever presses in extinction session 6	0.4	0.4	1.2	0.2	-1.0	0.1	0.2	1.1	-0.7	-0.4	0.7	0.4
Bone: final force	0.6	1.0	2.8	-1.4	1.1	-1.1	-1.7	-0.6	0.8	0.9	-0.3	0.0
Bone: final moment	0.7	1.2	3.2	-1.3	1.2	-1.1	-1.8	-0.7	1.0	1.1	-0.5	-0.2
Food consumed during 24 hour testing period	3.7	4.5	7.3	1.6	-2.3	2.7	2.2	2.2	-2.4	-2.0	2.1	1.1
Glucose	0.1	0.2	1.2	-0.1	0.1	0.0	0.3	0.2	-0.2	-0.3	0.2	1.1
Heart weight	0.6	0.9	2.9	-1.7	0.0	-0.8	-0.6	-0.3	-0.4	-0.2	0.9	-1.7
Delay discount hyperbolic model param	0.3	0.3	1.0	1.0	-0.9	0.6	0.5	0.6	-0.5	-0.3	-0.0	-0.4
Intermittent access intake day 1-15 change	1.7	1.7	5.2	-1.7	1.8	-0.8	0.2	-1.4	0.1	-0.6	0.4	2.3
Intermittent access intake escalation	1.5	1.4	4.3	-1.7	1.6	-0.9	0.2	-1.2	0.1	-0.7	0.3	2.1
Intermittent access intake escalation 2	2.1	2.1	5.1	-2.2	2.3	-1.6	-0.6	-1.8	0.6	-0.1	-0.3	1.5
Intermitt. access day 1 inactive lever presses	0.1	0.1	0.2	-0.5	-0.3	0.1	-0.4	0.1	-0.4	-0.1	0.3	0.3
Intermitt. access day 15 inactive lever presses	1.3	1.5	4.9	-0.2	-0.6	0.7	1.2	0.6	-1.3	-1.6	1.2	2.2
Intermitt. access escalation Index	0.5	0.4	1.8	-0.0	0.3	-0.6	-0.3	-0.4	0.8	0.6	-0.5	-1.3
Intermittent access day 1 total infusions	0.1	0.1	0.6	0.6	-0.4	0.8	-0.0	-0.1	-0.1	0.3	0.1	0.2
Intermittent access day 15 total infusions	0.8	0.9	2.9	-1.4	1.2	-0.6	-0.1	-1.3	0.1	-0.3	0.3	1.7
Intermittent access terminal intake (last 3 days)	1.1	1.2	2.8	-1.7	1.5	-1.1	-0.6	-1.6	0.5	0.1	-0.1	1.2
Intermittent access total infusions	0.3	0.3	1.2	-0.5	0.6	0.0	-0.2	-1.1	0.1	0.1	0.1	1.1
Intermittent access day 1 locomotion	0.3	0.3	1.0	-0.9	-0.1	0.1	0.0	-0.3	-0.5	-0.5	0.9	1.0
Intermittent access day 15 total locomotion	1.1	1.1	3.3	-1.8	1.2	-1.2	-1.0	-1.6	0.5	0.4	-0.2	0.6
Intermittent access total locomotion	0.7	0.8	2.5	-1.6	0.3	-0.1	-0.2	-0.9	-0.5	-0.5	1.1	1.4
Intermittent access standard deviation	1.5	1.6	7.5	-1.6	1.5	-0.8	-0.2	-1.2	0.0	-0.3	0.2	2.7
Left kidney weight	0.6	1.6	3.6	0.3	-1.7	1.1	0.8	1.4	-1.7	-1.1	1.9	0.1
Right kidney weight	0.5	1.5	4.8	-0.8	-1.2	-0.1	0.4	1.1	-1.6	-1.6	2.2	0.3
Cocaine induced anxiety	0.4	0.4	1.0	0.0	0.2	-0.9	-0.6	-0.3	0.9	0.9	-1.0	-0.0
Post-drug Anxiety	0.3	0.3	1.1	-0.3	0.4	-1.1	-0.4	-0.2	0.8	0.5	-0.7	-0.3
Baseline Anxiety	0.8	0.8	1.2	1.0	-0.8	1.1	1.1	1.0	-0.8	-0.9	0.8	-0.5
Tail length	0.2	0.8	2.6	-1.6	0.6	-0.5	-0.2	-0.9	-0.3	-0.7	1.2	-0.9
Length with tail	0.5	1.7	5.5	-2.1	0.1	-0.2	0.4	-0.8	-1.1	-1.7	2.4	0.6
Length without tail	0.7	1.5	4.4	-0.4	-0.8	0.0	1.2	0.2	-1.1	-1.7	1.6	2.1
Times rat made contact with spout	0.4	0.5	1.1	-0.1	-0.7	0.6	0.8	0.2	-0.8	-0.8	1.1	0.4
Lifetime Intake	0.1	0.2	0.6	-0.2	0.2	0.3	-0.3	-0.7	0.1	0.3	0.0	0.8
Liver weight, left	0.4	0.7	1.5	0.2	0.5	-0.3	-0.7	-0.9	1.0	1.0	-1.0	-1.2
Liver weight, right	0.4	0.6	1.7	1.3	-0.5	1.3	0.7	0.6	-0.4	-0.4	0.2	0.8
Locomotor activity	0.4	0.7	1.9	-0.0	-1.0	0.5	-0.3	1.0	-1.1	-0.4	1.4	-0.4
Locomotor testing distance	0.4	0.7	1.7	0.0	-1.0	0.6	-0.5	1.1	-0.9	0.1	1.2	-1.3
Locomotor testing rearing	1.1	1.7	3.6	0.4	-1.3	1.4	0.7	1.7	-1.7	-1.1	1.9	-0.6
Locomotion in novel chamber	0.4	0.5	0.8	0.2	-0.7	0.3	0.9	0.8	-0.7	-0.9	0.9	0.6
Locomotion in novel chamber post-restriction	0.1	0.1	0.5	0.0	0.2	0.3	0.2	-0.7	0.0	-0.1	0.2	-0.7
Fecal boli incidents, locomotor time 1	1.3	1.4	2.8	-1.5	1.7	-1.6	-1.0	-1.2	1.0	0.6	-1.0	0.6
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.1	0.6	0.5	-0.1	-0.4	0.3	0.2	0.1	0.2
Time >=10cm from walls, locomotor time 1	0.4	0.4	1.1	1.1	-0.2	1.0	0.2	-0.0	0.1	0.4	-0.7	0.9
Bouts of movement, locomotor time 1	1.1	1.2	2.0	0.2	-1.2	1.0	1.0	1.2	-1.4	-1.4	1.2	0.6
Total resting periods, locomotor time 1	0.6	0.6	1.6	-0.1	-0.7	0.4	0.8	0.7	-1.0	-1.2	0.9	0.6
Rest time, locomotor task time 1	0.2	0.2	1.2	-0.1	0.4	-0.1	0.4	-0.1	-0.0	-0.5	0.1	1.1
Distance moved, locomotor task time 1	1.5	1.6	3.3	1.2	-1.6	1.8	1.5	1.2	-1.3	-1.1	1.1	0.1
Vertical activity count, locomotor time 1	0.8	0.8	2.7	0.8	-1.1	1.7	1.0	0.7	-0.9	-0.7	0.4	-0.2
Time >=10cm from walls, locomotor time 2	4.6	4.9	6.5	1.9	-2.2	2.4	2.5	2.2	-2.3	-2.3	1.8	2.2
Bouts of movement, locomotor time 2	4.4	4.8	7.7	1.2	-2.8	2.1	2.2	2.7	-2.6	-2.3	2.0	1.0
Total resting periods, locomotor time 2	3.2	3.4	5.7	1.0	-2.4	1.8	1.8	2.3	-2.2	-1.9	1.7	0.8
Rest time, locomotor task time 2	0.7	0.8	1.8	0.2	1.1	-1.0	-0.4	-0.8	1.3	0.8	-1.4	-0.3
Distance moved, locomotor task time 2	5.7	6.6	8.7	2.1	-3.0	2.9	2.9	2.7	-2.8	-2.5	2.2	1.5
Vertical activity count, locomotor time 2	2.6	2.8	4.2	0.8	-1.8	2.1	1.7	1.6	-2.0	-1.7	1.7	1.5
Light reinforcement 1	1.3	2.4	4.4	1.8	-1.9	2.0	1.0	2.1	-1.4	-0.6	1.1	-1.4
Light reinforcement 2	0.2	0.3	0.8	0.4	-0.4	0.5	0.5	0.4	-0.5	-0.5	0.9	-0.4
Bone: marrow area	9.4	20.3	46.7	-6.8	5.5	-5.5	-4.8	-5.2	3.7	2.8	-1.9	-0.8
Bone: maximum diameter	4.4	8.1	12.8	-3.6	3.3	-3.1	-3.6	-3.2	2.6	2.5	-1.6	-1.2
Bone: maximum force	1.0	1.7	4.1	-2.0	1.5	-1.4	-2.0	-1.0	0.9	1.1	-0.3	0.0
Bone: maximum moment	1.1	1.9	4.4	-2.0	1.6	-1.4	-2.1	-1.1	1.0	1.2	-0.5	-0.2
Mean time between licks in bursts	0.9	1.2	2.8	-0.8	-0.6	-0.4	0.9	0.8	-1.4	-1.7	1.5	1.2
Mean num. licks in bursts	0.4	0.5	1.6	0.8	-1.3	0.7	0.4	0.8	-0.3	0.1	-0.2	-0.6
Cd content in liver	0.3	0.3	1.3	0.5	0.2	-1.2	0.2	-0.1	0.5	0.0	-0.9	-0.3
Co content in liver	0.3	0.3	0.7	-0.4	-0.6	-0.8	0.5	0.2	-0.3	-0.9	0.6	0.1
Cu content in liver	0.6	0.7	0.9	-0.6	0.8	-0.8	-0.8	-0.9	1.0	0.9	-0.9	-0.9
Fe content in liver	0.4	0.5	2.0	0.1	0.1	-0.4	-0.9	0.0	0.6	0.9	-0.8	-1.4
K content in liver	1.9	1.9	3.2	-0.3	1.4	-1.1	-1.6	-1.5	1.8	1.7	-1.3	-0.7
Mg content in liver	2.2	2.3	4.7	0.5	1.3	-1.0	-1.5	-1.2	2.1	2.1	-2.2	-0.7
Mn content in liver	2.1	2.4	5.1	0.5	1.0	-1.4	-2.0	-1.2	2.1	2.2	-1.8	-0.5
Na content in liver	0.8	0.8	1.4	0.2	1.1	-0.4	-1.2	-0.8	1.2	1.2	-0.8	0.6
Rb content in liver	0.5	0.7	1.6	0.5	0.7	0.0	-0.4	-1.3	1.2	1.0	-1.0	-0.4
Se content in liver	0.2	0.2	1.0	1.0	-0.1	0.3	0.2	-0.1	0.2	0.1	0.0	0.9
Sr content in liver	0.3	0.2	0.8	-0.5	-0.4	-0.0	0.2	0.5	-0.7	-0.5	0.9	-0.2
Zn content in liver	1.0	1.1	2.2	0.2	0.7	-0.8	-1.1	-1.0	1.3	1.5	-1.1	-1.2
Bone: minimum diameter	5.3	9.8	27.1	-5.2	3.6	-3.5	-3.7	-3.3	2.1	2.0	-0.8	-1.3
Time in familiar zone, hab. session 1	1.3	1.2	3.3	-1.8	1.7	-1.2	-0.8	-1.3	0.8	0.4	-0.5	0.5
Time in novel zone, hab. session 1	0.8	0.8	2.2	1.5	-1.1	1.0	0.6	1.1	-0.6	-0.1	0.3	-0.5
Total zone transitions, hab. session 1	1.3	1.8	3.3	0.8	-1.8	0.9	0.8	1.8	-1.7	-1.3	1.7	-0.1
Total locomotion distance, hab. session 1	1.1	1.6	2.9	1.2	-1.7	1.5	0.8	1.6	-1.4	-0.8	1.3	-0.4
Locomotion velocity, hab. session 1	1.2	1.7	3.5	1.2	-1.9	1.4	0.9	1.6	-1.4	-0.9	1.4	-0.5
Time in familiar zone, hab. session 2	0.7	0.7	2.2	-1.5	0.9	-0.8	-0.9	-0.9	0.5	0.5	-0.3	-0.3
Time in novel zone, hab. session 2	0.5	0.5	2.6	1.6	-0.6	0.4	0.4	0.4	0.2	0.4	-0.6	-0.5
Total zone transitions, hab. session 2	2.4	3.1	5.8	1.5	-2.3	1.4	1.5	2.4	-2.2	-1.5	1.8	-0.4
Total locomotion distance, hab. session 2	2.7	3.5	5.9	2.0	-2.3	2.1	1.9	2.4	-2.1	-1.4	1.5	-0.2
Locomotion velocity, hab. session 2	2.6	3.5	5.8	2.1	-2.3	2.2	1.8	2.4	-2.0	-1.3	1.3	-0.1
Novel to familiar place preference ratio	1.1	1.2	4.3	-2.1	1.2	-1.3	-1.1	-1.2	0.5	0.4	0.1	-0.4
Novelty place preference	0.8	0.8	2.8	-1.7	0.9	-1.1	-0.9	-0.9	0.4	0.3	0.1	-0.5
Time in novel zone, NPP test	0.8	0.8	2.4	-1.5	0.8	-1.1	-1.1	-0.8	0.5	0.5	-0.1	-0.8
Total zone transitions, NPP test	1.4	2.0	4.0	1.8	-1.9	1.6	0.4	2.0	-1.1	0.0	0.4	-1.8
Total locomotion distance, NPP test	1.6	2.1	4.0	2.0	-1.8	2.0	0.8	1.7	-0.9	0.1	0.2	-1.9
Locomotion velocity, NPP test	1.8	2.6	5.1	2.0	-2.1	2.3	1.2	1.9	-1.4	-0.4	0.7	-1.5
Intraocular pressure	0.2	0.3	1.3	-0.1	-0.6	0.4	0.1	0.8	-0.6	-0.1	0.5	-1.1
Delta distance traveled before/after self-admin	0.6	0.7	1.8	1.3	-0.9	1.0	0.3	1.3	-0.7	-0.2	0.3	0.1
Delta ambulatory time before/after self-admin	0.2	0.2	0.7	0.1	0.3	-0.5	-0.9	0.2	0.3	0.5	-0.4	-0.6
Parametrial fat weight	0.8	1.5	2.8	-0.3	1.5	-1.4	-1.0	-1.2	1.6	1.3	-1.7	-0.0
Pavlov. Cond. lever latency	1.5	1.9	6.3	0.0	1.3	-1.0	-0.8	-1.0	1.8	1.6	-2.5	-0.4
Pavlov. Cond. magazine entry latency	0.2	0.3	1.2	-1.1	0.2	-0.2	-0.5	-0.4	-0.2	-0.2	0.9	-0.3
Pavlov. Cond. change in total contacts	0.7	0.8	3.7	-0.7	-0.5	0.2	0.1	0.3	-1.1	-1.0	1.9	-0.2
Pavlov. Cond. index score	0.4	0.5	2.7	-0.8	-0.3	0.3	-0.1	0.1	-0.9	-0.8	1.6	0.0
Pavlov. Cond. latency score	0.8	1.0	4.5	-0.7	-0.6	0.4	0.3	0.4	-1.3	-1.2	2.1	0.3
Pavlov. Cond. lever contacts	2.0	2.4	6.7	0.1	-1.6	0.8	1.1	1.4	-2.1	-2.0	2.6	0.7
Pavlov. Cond. magazine entry number	0.2	0.3	1.1	1.0	-0.5	0.3	0.6	0.6	-0.0	0.0	-0.6	0.0
Pavlov. Cond. intertrial magazine entries	1.0	1.3	3.6	-1.9	1.0	-0.7	-1.3	-0.9	0.4	0.8	0.0	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	2.3	-0.7	-0.3	0.2	-0.2	0.2	-0.8	-0.6	1.5	-0.0
Pavlov. Cond. response bias	0.3	0.3	1.6	-0.5	-0.2	0.1	-0.2	0.1	-0.6	-0.5	1.3	-0.3
Pavlov. Cond. lever latency	1.8	2.4	4.4	1.0	-1.5	1.0	2.1	1.3	-1.5	-2.0	1.2	1.9
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	-0.1	0.5	0.4	-0.3	-0.2	0.2	0.4	-0.6	0.1
Pavlov. Cond. change in total contacts	1.0	1.4	2.4	-1.0	1.3	-0.9	-1.5	-1.0	1.1	1.4	-1.0	-1.3
Pavlov. Cond. index score	1.0	1.3	2.7	-1.1	1.2	-0.8	-1.6	-1.0	1.0	1.3	-0.8	-1.1
Pavlov. Cond. latency score	1.1	1.4	2.7	-1.1	1.3	-0.7	-1.6	-1.1	1.1	1.4	-1.0	-1.2
Pavlov. Cond. lever contacts	0.9	1.2	3.2	-0.5	0.8	-0.6	-1.5	-0.7	0.9	1.4	-0.7	-1.8
Pavlov. Cond. magazine entry number	0.0	0.1	0.3	-0.1	-0.1	-0.5	0.1	-0.3	0.2	-0.0	0.2	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-0.8	0.5	-0.9	-1.0	-0.5	0.7	0.7	-0.5	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.3	2.8	-1.1	1.3	-0.8	-1.7	-1.0	1.1	1.3	-0.9	-1.0
Pavlov. Cond. response bias	0.8	1.1	2.3	-0.7	1.0	-0.8	-1.5	-0.8	1.0	1.3	-0.8	-1.2
Time in closed arm before self-admin	1.2	1.4	3.4	1.0	-1.1	1.9	1.0	1.1	-1.3	-0.9	1.4	0.5
Time in closed arm after self-admin	0.2	0.2	0.8	-0.1	-0.0	0.4	0.4	0.1	-0.4	-0.6	0.6	0.9
Time in open arm before self-admin	1.1	1.2	2.9	-0.7	-0.6	0.2	1.3	0.4	-1.2	-1.7	1.1	1.6
Time in open arm after self-admin	0.1	0.1	0.4	-0.2	-0.1	0.1	0.6	0.3	-0.4	-0.5	0.4	0.2
Bone: periosteal estimation	5.7	11.8	27.0	-5.2	4.1	-3.8	-4.2	-3.7	2.7	2.5	-1.2	-1.4
Bone: periosteal perimeter	4.2	7.0	17.5	-4.2	3.2	-3.1	-3.3	-2.6	1.8	1.7	-0.7	-0.5
Bone: post-yield work	1.3	1.8	5.6	-2.4	1.6	-1.9	-1.5	-1.3	0.8	0.5	-0.2	0.2
Progressive ratio test 1 active lever presses	2.1	2.2	4.6	1.2	-1.6	2.1	1.2	1.1	-1.6	-1.1	1.5	1.7
Progressive ratio test 1 breakpoint	2.0	2.0	4.4	1.0	-1.5	2.1	1.1	1.0	-1.5	-1.0	1.6	1.6
Progressive ratio test 1 inactive lever presses	0.8	0.8	1.5	0.1	-1.2	1.2	0.1	1.0	-1.2	-0.6	1.2	0.6
Progressive ratio test 2 active lever presses	0.2	0.2	0.8	-0.1	0.4	0.2	-0.1	-0.8	0.1	0.1	0.2	0.9
Progressive ratio test 2 breakpoint	0.2	0.2	0.8	-0.0	0.5	0.2	-0.1	-0.7	0.2	0.2	0.1	0.9
Progressive ratio test 2 inactive lever presses	0.7	0.8	2.7	-0.8	1.2	-0.6	-0.8	-1.6	0.8	0.6	-0.3	0.3
Incentive Sensitization - Responses	1.0	1.0	2.3	-0.6	1.5	-0.9	-0.8	-1.5	1.2	0.8	-0.6	-0.1
Incentive Sensitization - Breakpoint	1.0	1.0	2.3	-0.6	1.5	-1.0	-0.7	-1.5	1.2	0.8	-0.6	-0.0
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.7	-0.1	-0.3	0.4	0.5	0.9	-0.7	-0.6	0.6	0.3
Progressive ratio	0.2	0.3	0.8	-0.6	0.4	-0.9	-0.0	-0.7	0.5	0.0	-0.5	-0.1
Food seeking constrained by brief footshock	0.5	0.6	2.1	-0.9	0.9	-1.5	-0.6	-0.7	0.6	0.3	-0.3	0.3
Seeking ratio, punishment vs. effort	0.1	0.1	0.2	0.2	-0.1	0.2	-0.2	0.4	-0.3	0.0	0.4	0.4
Retroperitoneal fat weight	3.8	12.5	21.9	-0.2	-2.9	2.4	3.7	3.0	-4.5	-4.7	4.6	3.6
Reaction time number correct	0.4	0.6	1.3	0.5	0.4	-0.4	-0.8	-0.3	0.9	1.1	-1.0	-1.1
Reaction time mean minus median	0.6	0.8	3.2	-0.3	0.3	0.0	1.2	-0.3	-0.5	-1.4	0.8	1.8
Reaction time mean minus median AUC	0.4	0.5	1.7	-0.2	1.3	-0.7	-0.1	-1.2	0.8	0.3	-0.6	0.4
Reaction time num false alarms	0.8	1.0	3.0	-1.5	0.6	-0.6	-1.6	-0.4	0.2	0.8	0.1	-1.7
Reaction time num false alarms AUC	1.1	1.5	3.3	-1.8	0.8	-1.0	-1.8	-0.8	0.6	1.1	-0.1	-1.8
Reaction time trials correct on left	0.4	0.6	1.3	0.5	0.4	-0.4	-0.8	-0.3	0.9	1.1	-1.0	-1.1
Reaction time trials on left	0.5	0.7	1.3	0.4	0.4	-0.5	-0.8	-0.4	1.0	1.1	-1.0	-1.1
Reaction time mean	0.4	0.6	1.8	-0.3	1.4	-0.4	-0.1	-1.2	0.9	0.3	-0.7	0.5
Reaction time mean AUC	0.3	0.4	1.3	-0.0	1.1	-0.1	0.2	-0.9	0.7	0.0	-0.5	0.6
Median of all reaction times	0.7	0.9	2.2	-0.3	1.5	-0.5	-0.6	-1.3	1.3	0.8	-1.1	-0.0
Reaction time omissions	0.1	0.2	0.5	-0.4	0.7	-0.6	0.0	-0.5	0.3	-0.0	-0.6	0.4
Reaction time false alarm rate	0.4	0.6	2.7	-1.6	0.5	-0.5	-1.1	-0.4	-0.1	0.3	0.5	-0.9
Reaction time premature initiation rate	0.3	0.4	2.1	-1.5	0.4	0.0	-0.3	0.1	-0.5	-0.4	1.0	-0.3
Reaction time premature initiations	0.4	0.5	1.2	-1.1	0.7	-0.4	-0.9	-0.3	0.3	0.6	0.1	-1.1
Std. dev. reaction times	0.4	0.5	1.5	-0.4	1.1	-0.5	0.5	-1.0	0.5	-0.4	-0.5	1.2
Reaction time trials completed	0.5	0.7	1.3	0.4	0.4	-0.5	-0.8	-0.4	1.0	1.1	-1.0	-1.1
Reaction time trials AUC	0.4	0.6	1.2	0.5	0.4	-0.4	-0.7	-0.3	1.0	1.1	-1.1	-1.1
Run reversals in cocaine runway, females	8.0	7.7	14.6	0.6	-2.3	1.9	3.0	2.5	-3.4	-3.8	3.1	3.0
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.4	0.2	-0.4	-0.2	-0.2	0.5	0.2	-0.3	-0.5
Latency to leave start box in cocaine runway	3.8	4.1	11.2	2.3	-2.4	3.3	2.2	2.1	-1.7	-1.1	1.2	-0.0
Latency to leave start box in cocaine runway, F	4.2	4.6	9.5	1.9	-2.6	3.1	2.1	2.6	-2.2	-1.5	1.7	0.4
Latency to leave start box in cocaine runway, M	1.4	1.3	3.5	1.7	-1.2	1.9	1.6	0.4	-0.7	-0.7	0.5	0.1
Std. dev. time between licks in bursts	1.3	1.6	2.9	1.4	-1.1	1.1	1.3	1.7	-1.4	-1.3	1.0	0.8
Total sessions with >9 infusions	0.2	0.3	1.1	0.6	-0.5	1.0	0.1	0.3	-0.4	0.1	0.6	-0.3
Short access day 1 total inactive lever presses	0.2	0.2	0.8	0.5	-0.8	0.5	0.2	0.4	-0.3	-0.1	0.2	0.9
Short access day 10 total inactive lever presses	0.3	0.4	1.0	-1.0	0.6	-0.8	-0.7	-0.7	0.2	0.2	-0.5	-0.4
Short access day 1 total infusions	0.9	0.9	2.3	1.4	-1.5	1.5	0.2	1.1	-0.6	0.1	0.5	-0.3
Short access day 10 total infusions	0.8	0.9	1.7	0.1	-0.9	1.3	0.5	0.5	-1.2	-0.8	1.3	1.0
Short access total infusions	0.2	0.2	0.8	0.4	-0.6	0.9	-0.3	0.2	-0.3	0.4	0.3	0.2
Short access day 1 locomotion	1.2	1.2	2.7	0.7	-1.6	1.4	0.6	1.4	-1.2	-0.7	1.3	0.2
Short access day 10 total locomotion	1.2	1.4	5.3	-1.4	-0.0	0.3	0.4	-0.1	-1.0	-1.1	1.6	2.3
Short access total locomotion	1.8	1.8	4.3	-0.2	-1.5	1.5	1.0	1.1	-1.7	-1.4	2.1	0.7
One hour access (0.3 mA shock)	2.0	2.4	4.7	-1.3	2.2	-1.4	-1.7	-2.0	1.5	1.5	-1.2	0.0
Compulsive drug intake	3.0	3.0	5.1	-2.0	2.3	-2.1	-1.8	-2.0	1.6	1.3	-1.0	-1.0
One hour access (shock baseline)	0.0	0.0	0.3	0.0	0.1	0.1	0.0	-0.1	-0.1	-0.0	-0.2	0.5
Social response proportion	0.8	0.9	2.4	-1.3	1.2	-1.5	-1.1	-0.5	0.6	0.3	-0.3	0.4
Social responses	0.1	0.2	0.6	-0.8	0.1	-0.2	-0.8	0.3	-0.4	0.0	0.4	0.2
Social time	0.7	0.9	3.3	-1.4	1.1	-1.8	-0.6	-0.9	0.6	0.1	-0.2	0.2
Soleus weight	0.3	1.0	2.7	-1.0	-0.0	-0.7	0.1	0.3	-0.9	-1.1	1.6	1.6
Bone: stiffness	0.7	1.1	3.1	-1.8	1.4	-1.1	-1.5	-0.9	0.7	0.6	-0.1	0.1
Tibialis anterior weight	1.6	5.5	11.3	0.2	-2.1	0.9	2.3	2.2	-3.0	-3.4	3.3	1.5
Time to tail flick, vehicle, before self-admin	0.5	0.5	1.0	-1.0	0.9	-0.9	0.0	-1.0	0.6	-0.0	-0.6	0.0
Time to tail flick, vehicle, after self-admin	2.7	2.9	5.7	-2.0	2.4	-2.1	-1.5	-2.1	1.7	1.0	-0.9	-0.1
Time to tail flick, test, before self-admin	1.6	1.6	5.7	-2.4	1.5	-1.7	-0.4	-1.6	0.7	-0.2	0.1	0.1
Time to tail flick, test, after self-admin	1.9	2.0	3.1	-1.8	1.7	-1.6	-1.4	-1.5	1.4	1.1	-1.1	-0.7
Delta time to tail flick, vehicle, before/after SA	2.3	2.3	3.2	-1.1	1.8	-1.7	-1.8	-1.7	1.8	1.6	-1.2	-0.3
Delta time to tail flick, test, before/after SA	2.6	2.3	3.3	-0.8	1.6	-1.2	-1.6	-1.6	1.7	1.8	-1.8	-1.3
Tibia length	0.7	2.0	6.9	-0.9	-0.6	0.9	1.1	0.2	-1.5	-2.0	2.6	1.1
Ambulatory time before self-admin	0.2	0.2	0.6	0.2	-0.4	0.6	0.7	0.2	-0.3	-0.5	0.8	-0.1
Ambulatory time after self-admin	0.2	0.2	0.9	0.0	-0.3	0.1	-0.2	0.9	-0.2	-0.1	0.3	-1.0
Bone: tissue strength	0.4	0.4	2.2	1.5	-0.2	0.8	0.1	0.6	0.2	0.5	-0.6	0.3
Total heroin consumption	0.1	0.1	0.4	-0.4	0.2	-0.5	-0.6	-0.1	0.3	0.3	-0.1	0.0
Bone: trabecular number	2.7	4.3	7.3	-0.5	1.5	-2.5	-2.7	-1.2	2.4	2.6	-2.6	-1.2
Bone: trabecular spacing	1.3	1.7	3.6	0.5	-1.1	1.9	1.7	0.8	-1.5	-1.6	1.4	0.6
Bone: trabecular thickness	1.4	1.7	2.8	-1.4	1.1	-1.6	-1.7	-1.1	1.2	1.3	-1.0	-1.2
Bone: trabecular tissue density	0.4	0.5	2.1	0.3	-0.3	1.4	0.8	0.5	-0.6	-0.7	0.6	0.6
Water consumed over 24 hours	2.6	3.1	5.2	2.0	-2.0	2.3	1.7	2.0	-1.9	-1.4	1.4	0.8
Number of responses in last shaping day	3.2	3.3	7.6	0.8	-1.3	2.1	2.0	1.2	-1.8	-1.8	1.9	2.8