Axin2

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression Axin2 0.06 0.03 7.1e-09 0.07 0.06 0.06 0.07 1.5e-10 1.3e-09 6.0e-10 2.3e-10
2 PL gene expression Axin2 0.15 0.06 1.7e-12 0.08 0.11 0.12 0.1 4.1e-09 8.2e-12 7.2e-13 1.9e-11
3 Brain gene expression Axin2 0.31 0.1 0.0e+00 0.25 0.27 0.28 0.24 4.0e-23 3.2e-25 1.4e-26 1.3e-22
4 NAcc alternative TSS XM_039085702.2 0.03 0.02 1.5e-03 0.02 0.02 0.01 0.01 7.3e-04 1.1e-03 1.0e-02 1.9e-03
5 IC gene expression Axin2 0.16 0.08 4.5e-06 0.11 0.16 0.13 0.15 2.6e-05 4.2e-07 4.0e-06 5.9e-07
6 IL gene expression Axin2 0.3 0.12 1.1e-05 0.1 0.15 0.08 0.11 2.4e-03 1.8e-04 6.9e-03 1.4e-03
7 NAcc alternative TSS XM_039085703.2 0.02 0.01 9.8e-03 0.01 0.01 0 0.01 2.0e-02 6.0e-03 7.8e-02 2.9e-02
8 Adipose gene expression Axin2 0.4 0.12 0.0e+00 0.18 0.2 0.2 0.2 2.7e-19 1.9e-21 2.0e-21 3.4e-22
9 NAcc alternative TSS XM_039085703.2 0.02 0.01 6.4e-03 0.01 0.01 0 0.01 1.4e-02 4.4e-03 6.5e-02 2.0e-02
10 BLA gene expression Axin2 0.09 0.05 3.4e-04 0.06 0.05 0.04 0.05 3.2e-04 1.5e-03 2.6e-03 1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density2.85.19.9-3.2-3.0-2.61.21.92.21.82.11.9-2.1
Area under the delay curve0.00.00.1-0.2-0.1-0.00.10.20.10.10.10.00.2
BMI with tail6.221.631.53.53.24.4-3.9-5.3-5.4-5.6-3.7-5.65.2
BMI without tail5.127.139.54.23.35.1-3.8-5.9-5.9-6.3-4.0-6.36.1
Body weight6.026.449.12.32.85.2-2.2-5.5-6.0-6.5-3.7-6.97.0
Weight adjusted by age1.54.56.81.82.32.6-1.3-2.0-2.3-2.0-2.5-2.12.1
Bone surface4.89.518.3-4.2-4.3-3.52.52.72.92.23.22.1-2.2
Bone volume3.97.816.0-4.0-4.0-3.32.12.32.51.83.01.7-2.0
Breakpoint value in progressive ratio session1.32.47.01.61.01.3-2.6-1.7-1.4-1.3-1.8-1.10.7
Number of licking bursts0.00.10.4-0.40.10.40.70.1-0.2-0.10.0-0.20.5
Context. condit. distance diff. score0.10.10.20.30.10.2-0.3-0.3-0.3-0.4-0.3-0.40.3
Locomotion velocity, session 10.00.00.10.0-0.3-0.3-0.1-0.10.0-0.2-0.1-0.1-0.1
Locomotion distance, session 10.10.20.30.2-0.6-0.3-0.6-0.5-0.2-0.50.0-0.40.1
Locomotion velocity, session 20.40.51.60.0-1.1-1.3-0.10.20.70.31.00.5-0.7
Locomotion distance, session 20.20.30.80.5-0.7-0.8-0.9-0.50.1-0.30.40.0-0.3
Locomotion velocity, session 31.31.53.41.90.30.7-1.7-1.6-1.1-1.3-0.8-1.01.0
Locomotion distance, session 30.10.10.8-0.4-0.9-0.40.20.10.30.10.40.2-0.1
Stereotopy head waving bouts, day 30.81.02.41.40.5-0.3-0.60.50.81.3-0.31.5-1.6
Stereotopy head waving duration, day 30.50.71.80.90.0-0.6-0.40.50.81.00.01.3-1.3
Locomotion velocity, session 70.10.10.9-0.00.0-0.4-0.9-0.3-0.0-0.1-0.0-0.0-0.3
Locomotion distance, session 70.30.41.3-0.8-0.9-1.00.50.30.4-0.01.1-0.0-0.0
Stereotopy head waving bouts, day 70.30.41.40.40.30.4-1.2-0.20.00.4-1.00.5-0.5
Stereotopy head waving duration, day 70.40.51.10.40.50.3-1.00.20.30.9-1.11.1-0.9
Locomotion velocity, session 80.10.10.20.40.1-0.50.30.30.30.30.00.3-0.4
Locomotion distance, session 80.20.20.70.4-0.8-0.8-0.4-0.40.1-0.40.6-0.2-0.1
Degree of sensitization distance0.20.21.0-0.2-0.2-0.90.50.40.40.11.00.1-0.3
Degree of sensitization stereotypy0.80.82.60.50.40.9-1.6-1.0-0.8-0.6-1.5-0.40.4
Conditioned locomotion0.50.61.1-0.7-1.0-1.00.30.60.80.60.90.7-0.7
Cocaine response after cond. corrected0.30.41.3-1.1-0.4-0.50.90.80.60.60.60.4-0.2
Cocaine response after cond. not corrected0.30.51.6-1.3-0.4-0.51.00.80.60.60.60.4-0.2
Cocaine response before conditioning0.00.10.10.2-0.2-0.30.30.20.30.20.20.2-0.2
Saline control response5.06.99.22.41.42.5-2.4-3.0-2.9-3.0-2.3-2.92.9
Bone: connectivity density3.96.39.8-2.7-3.1-3.01.12.22.62.32.32.5-2.7
Bone: cortical apparent density0.81.24.62.11.31.0-1.6-0.7-0.6-0.1-1.30.1-0.2
Bone: cortical area0.40.62.9-0.2-1.7-0.9-0.1-0.40.0-0.71.1-0.60.3
Bone: cortical porosity1.21.34.7-1.6-2.2-1.21.30.60.80.11.40.1-0.0
Bone: cortical porosity0.60.72.9-1.1-1.7-0.50.8-0.10.0-0.60.7-0.70.7
Bone: cortical thickness4.37.114.43.81.82.1-3.7-3.1-2.5-2.5-2.4-2.11.7
Bone: cortical thickness0.91.24.71.80.30.3-2.2-1.2-0.7-0.7-0.9-0.3-0.1
Bone: cortical tissue density0.81.34.52.11.41.0-1.6-0.7-0.6-0.1-1.40.1-0.2
Condit. Reinf. active minus inactive responses0.70.82.6-0.6-1.2-0.51.60.30.2-0.41.5-0.50.7
Condit. Reinf. active-inactive response ratio0.50.52.4-0.9-0.4-0.21.50.80.50.50.90.30.0
Condit. Reinf. active responses0.81.03.6-0.7-1.6-1.11.30.20.4-0.41.9-0.50.5
Condit. Reinf. inactive responses0.40.51.7-0.2-1.3-1.2-0.1-0.30.2-0.51.2-0.30.0
Incentive salience index mean0.30.41.1-0.3-0.9-0.20.8-0.2-0.1-0.61.1-0.60.8
Condit. Reinf. lever presses0.50.81.30.60.20.9-0.9-1.1-1.0-1.1-0.4-1.01.0
Condit. Reinf. active minus inactive responses2.33.58.8-2.3-3.0-2.02.31.31.50.62.60.6-0.3
Condit. Reinf. active-inactive response ratio1.93.06.2-2.5-2.4-1.72.31.41.40.82.20.7-0.4
Condit. Reinf. active responses2.63.79.8-2.2-3.1-2.42.21.11.50.42.80.3-0.3
Condit. Reinf. inactive responses0.40.62.10.2-1.5-1.40.1-0.10.5-0.31.3-0.1-0.2
Condit. Reinf. lever presses0.50.83.0-0.8-1.7-0.81.00.00.2-0.51.3-0.50.6
Condit. Reinf. lever reinforcers received2.33.28.3-2.2-2.9-2.22.11.01.30.32.70.3-0.2
Conditioned reinforcement - actives0.41.72.6-1.2-1.4-1.31.61.41.21.21.31.1-1.3
Conditioned reinforcement - inactives0.00.10.4-0.5-0.6-0.40.40.2-0.1-0.20.1-0.30.2
Conditioned locomotion0.30.51.4-1.2-0.9-0.41.20.20.0-0.30.6-0.50.7
Patch foraging indifference point 0 sec0.61.53.91.0-0.9-0.10.6-1.3-1.0-2.00.8-1.91.6
Patch foraging indifference point AUC0.10.20.50.4-0.00.20.3-0.3-0.4-0.60.2-0.60.7
Delay disc. indifference point, 0s delay0.10.10.3-0.50.10.5-0.10.2-0.00.3-0.40.10.2
Delay disc. indifference point, 16s delay0.20.30.60.30.70.6-0.2-0.4-0.5-0.5-0.4-0.60.8
Delay disc. indifference point, 2s delay0.40.40.7-0.7-0.5-0.40.80.70.80.70.70.6-0.1
Delay disc. indifference point, 24s delay0.10.20.6-0.7-0.8-0.5-0.0-0.1-0.1-0.40.4-0.50.4
Delay disc. indifference point, 4s delay0.00.00.1-0.1-0.20.0-0.10.30.30.40.20.3-0.2
Delay disc. indifference point, 8s delay0.20.30.80.60.80.7-0.7-0.3-0.4-0.1-0.9-0.10.3
Indifference point function ln k0.41.12.6-0.0-1.2-1.60.10.61.20.71.31.1-1.3
Indifference point function log k0.41.12.6-0.0-1.2-1.60.10.61.20.71.31.1-1.3
Patch foraging total patch changes 0 sec0.51.53.81.2-0.6-0.00.5-1.3-1.0-2.00.7-1.81.6
Patch foraging total patch changes 12 sec0.40.51.2-0.3-0.9-0.41.1-0.2-0.2-0.81.0-0.90.8
Patch foraging total patch changes 18 sec0.81.94.11.60.30.8-0.6-1.6-1.5-2.0-0.4-1.91.7
Patch foraging total patch changes 24 sec0.20.82.50.1-1.6-0.90.3-0.6-0.3-1.21.1-1.10.8
Patch foraging total patch changes 6 sec1.11.95.10.4-0.70.10.7-1.3-1.2-2.20.8-2.32.0
Patch foraging time to switch 0 sec0.10.41.1-0.40.90.9-0.5-0.2-0.6-0.2-1.1-0.40.3
Patch foraging water rate 0 sec0.10.51.50.4-0.9-0.51.0-0.30.0-0.61.2-0.50.7
Patch foraging water rate 12 sec0.31.01.71.30.60.8-0.5-1.2-1.1-1.3-0.7-1.21.0
Patch foraging water rate 18 sec0.10.20.80.3-0.5-0.6-0.9-0.40.1-0.20.20.1-0.4
Patch foraging water rate 24 sec0.20.30.90.1-0.8-0.9-0.10.20.60.40.70.6-0.6
Patch foraging water rate 6 sec0.10.10.60.8-0.1-0.1-0.6-0.30.1-0.10.30.10.0
Seeking ratio, delayed vs. immediate footshock0.81.13.20.70.91.1-0.2-1.0-1.1-1.2-0.5-1.31.8
Distance traveled before self-admin0.10.20.40.70.60.7-0.6-0.5-0.3-0.2-0.5-0.10.3
Distance traveled after self-admin0.00.00.1-0.1-0.20.2-0.3-0.20.0-0.20.0-0.2-0.0
Extensor digitorum longus weight3.012.019.41.94.14.4-3.1-3.2-3.8-2.9-4.4-3.13.1
Bone: elastic displacement0.40.51.51.00.40.3-1.2-0.9-0.4-0.5-0.8-0.30.3
Bone: elastic work1.01.42.40.60.31.1-1.3-1.5-1.2-1.4-1.1-1.21.3
Bone: endosteal estimation6.315.335.1-5.9-4.9-3.75.53.53.02.04.71.4-1.1
Bone: endosteal perimeter6.315.533.2-5.8-5.2-4.15.23.43.11.84.91.3-1.2
Epididymis fat weight3.618.426.12.64.05.1-2.6-4.2-5.0-4.5-4.3-4.85.0
Delta time in closed arm before/after self-admin1.61.52.2-1.2-0.7-1.10.81.41.31.51.01.4-1.5
Delta time in open arm before/after self-admin0.10.10.40.6-0.2-0.4-0.20.10.30.30.30.5-0.4
Diff in mean of infusions in LGA sessions1.52.65.11.61.61.6-2.3-1.7-1.6-1.3-2.0-1.30.9
Delay discount exponential model param0.10.10.20.50.30.2-0.4-0.3-0.3-0.2-0.3-0.1-0.2
Extinction: sum of active levers before priming0.71.02.80.10.30.8-1.7-1.2-1.1-1.1-0.9-1.10.8
Active lever presses in extinction session 60.20.20.9-0.3-0.50.0-0.9-0.4-0.3-0.4-0.4-0.30.1
Bone: final force0.71.13.3-1.3-1.8-1.00.90.80.80.61.20.5-0.6
Bone: final moment0.81.33.7-1.4-1.9-1.21.00.91.00.71.40.7-0.8
Food consumed during 24 hour testing period2.55.07.02.72.02.1-2.2-2.5-2.4-2.3-2.0-2.21.9
Glucose0.30.51.00.20.60.8-1.0-0.8-0.7-0.7-0.6-0.70.6
Heart weight0.71.12.7-0.3-0.10.6-0.5-1.2-1.1-1.5-0.6-1.61.7
Delay discount hyperbolic model param0.10.10.20.40.30.2-0.4-0.4-0.3-0.2-0.3-0.1-0.2
Intermittent access intake day 1-15 change0.10.41.6-1.00.30.41.30.4-0.3-0.1-0.5-0.50.9
Intermittent access intake escalation0.10.51.3-0.60.50.61.10.1-0.5-0.4-0.5-0.71.1
Intermittent access intake escalation 20.40.62.7-1.5-0.2-0.11.70.80.20.20.3-0.10.4
Intermitt. access day 1 inactive lever presses0.10.71.60.20.10.7-0.4-0.9-1.1-1.2-0.9-1.31.0
Intermitt. access day 15 inactive lever presses0.31.42.70.31.31.6-0.4-0.8-1.4-1.0-1.7-1.31.3
Intermitt. access escalation Index0.10.20.50.40.70.6-0.2-0.2-0.10.0-0.40.00.5
Intermittent access day 1 total infusions0.00.10.40.6-0.6-0.30.1-0.3-0.2-0.50.2-0.30.4
Intermittent access day 15 total infusions0.20.61.9-0.2-0.20.41.1-0.3-0.7-0.8-0.2-1.01.4
Intermittent access terminal intake (last 3 days)0.40.84.3-1.2-0.8-0.32.10.50.1-0.10.6-0.40.8
Intermittent access total infusions0.40.52.6-0.4-1.0-0.51.60.40.1-0.10.7-0.20.4
Intermittent access day 1 locomotion0.61.12.70.4-0.30.40.1-1.1-1.2-1.6-0.3-1.61.6
Intermittent access day 15 total locomotion0.10.51.2-0.7-1.1-0.50.6-0.2-0.4-0.80.5-0.90.8
Intermittent access total locomotion1.11.43.40.1-1.0-0.00.9-0.9-1.1-1.70.2-1.81.8
Intermittent access standard deviation0.10.52.3-1.3-0.20.21.50.5-0.3-0.2-0.2-0.50.4
Left kidney weight0.32.23.80.90.61.3-1.2-1.8-1.7-1.9-1.1-1.82.0
Right kidney weight0.43.15.10.60.61.8-1.5-2.0-2.0-2.0-1.7-2.12.3
Cocaine induced anxiety0.82.13.2-1.8-1.4-1.60.41.51.51.41.31.4-1.6
Post-drug Anxiety0.91.11.7-1.1-1.0-1.2-0.50.91.11.10.81.1-1.3
Baseline Anxiety0.50.91.61.31.01.1-1.2-0.8-0.7-0.4-1.1-0.40.7
Tail length0.63.49.11.00.51.90.4-1.8-2.0-2.4-0.7-2.53.0
Length with tail0.93.911.6-0.20.62.21.3-1.5-2.1-2.3-1.0-2.73.4
Length without tail0.31.74.0-0.70.81.60.4-0.8-1.5-1.3-1.3-1.72.0
Times rat made contact with spout0.60.71.40.60.60.9-0.2-0.9-1.0-1.0-0.7-1.01.2
Lifetime Intake0.30.31.40.1-0.8-0.41.2-0.0-0.1-0.50.5-0.40.6
Liver weight, left0.50.82.7-1.1-1.6-1.11.00.30.4-0.11.3-0.20.2
Liver weight, right1.32.22.81.51.31.6-1.6-1.6-1.6-1.4-1.7-1.41.2
Locomotor activity1.01.63.70.7-0.90.3-1.0-1.7-1.3-1.90.0-1.81.4
Locomotor testing distance0.82.14.60.8-0.80.5-1.4-2.0-1.5-2.2-0.1-2.01.7
Locomotor testing rearing1.03.66.81.50.31.3-1.6-2.5-2.1-2.6-0.8-2.42.3
Locomotion in novel chamber0.40.51.20.81.11.0-0.7-0.3-0.4-0.1-1.1-0.10.3
Locomotion in novel chamber post-restriction0.10.20.70.30.40.10.80.50.30.50.10.40.1
Fecal boli incidents, locomotor time 10.41.12.1-1.5-0.9-1.01.31.21.01.00.90.8-0.9
Change in fecal boli incidents, locomotor task0.30.30.6-0.3-0.0-0.20.60.70.60.80.20.7-0.4
Time >=10cm from walls, locomotor time 10.20.30.90.70.1-0.40.20.40.40.50.20.7-0.9
Bouts of movement, locomotor time 10.81.01.50.60.51.0-0.8-1.1-1.2-1.2-1.0-1.21.0
Total resting periods, locomotor time 10.40.50.90.10.50.8-0.5-0.7-0.9-0.7-0.9-0.80.7
Rest time, locomotor task time 10.10.20.4-0.60.50.30.30.50.10.6-0.50.4-0.2
Distance moved, locomotor task time 10.61.83.21.81.31.3-1.4-1.5-1.3-1.3-0.9-1.21.0
Vertical activity count, locomotor time 10.10.92.31.51.00.9-1.0-1.0-0.9-0.9-0.4-0.80.5
Time >=10cm from walls, locomotor time 21.44.15.92.32.42.3-2.2-1.9-2.0-1.6-2.3-1.51.3
Bouts of movement, locomotor time 21.85.97.92.41.92.0-2.6-2.8-2.7-2.7-2.4-2.62.0
Total resting periods, locomotor time 21.14.35.92.01.51.6-2.2-2.4-2.3-2.4-1.9-2.31.7
Rest time, locomotor task time 21.22.04.3-1.2-0.3-0.90.91.81.62.10.52.0-1.7
Distance moved, locomotor task time 24.66.28.12.82.72.7-2.7-2.5-2.5-2.2-2.4-2.11.9
Vertical activity count, locomotor time 21.43.44.22.01.51.9-1.7-2.0-2.0-2.0-1.4-2.01.6
Light reinforcement 10.52.34.81.90.60.9-2.2-2.0-1.4-1.7-0.7-1.41.3
Light reinforcement 20.10.30.90.40.30.8-0.4-0.7-0.6-0.5-0.4-0.50.9
Bone: marrow area6.114.934.2-5.9-4.8-3.65.43.53.02.04.61.4-1.2
Bone: maximum diameter3.67.313.2-3.3-3.6-2.93.22.52.41.73.31.5-1.4
Bone: maximum force1.01.96.8-1.9-2.6-1.51.30.80.90.41.80.3-0.5
Bone: maximum moment1.22.27.1-2.0-2.7-1.71.40.91.10.51.90.4-0.6
Mean time between licks in bursts0.31.52.6-0.31.11.4-0.6-1.1-1.5-1.4-1.2-1.61.5
Mean num. licks in bursts0.10.20.60.80.30.1-0.8-0.6-0.4-0.5-0.4-0.40.2
Cd content in liver0.80.91.9-0.81.4-0.10.51.10.61.3-0.31.1-1.1
Co content in liver0.40.51.4-0.00.81.1-0.7-0.5-0.7-0.4-1.2-0.40.5
Cu content in liver0.20.30.6-0.7-0.4-0.40.80.50.50.40.60.3-0.2
Fe content in liver0.60.72.2-0.6-1.5-1.20.70.50.70.41.10.5-0.4
K content in liver1.31.31.8-0.6-1.1-1.01.31.21.31.21.11.3-0.8
Mg content in liver1.92.13.7-0.9-1.1-1.30.81.51.71.81.11.9-1.7
Mn content in liver2.42.64.4-0.8-1.6-1.70.81.51.91.91.42.1-1.9
Na content in liver0.70.81.3-0.3-0.7-0.70.91.01.01.10.61.1-0.9
Rb content in liver0.70.81.80.1-0.2-0.40.91.11.01.30.51.3-1.0
Se content in liver0.00.10.30.6-0.20.0-0.0-0.00.20.20.00.3-0.1
Sr content in liver0.90.81.40.40.60.8-0.6-1.0-1.0-1.2-0.8-1.21.1
Zn content in liver0.80.91.2-1.0-1.0-1.10.80.91.00.81.10.9-0.7
Bone: minimum diameter3.77.217.0-4.1-4.1-2.73.61.81.70.53.50.1-0.1
Time in familiar zone, hab. session 10.50.61.9-1.1-0.3-0.61.40.90.60.40.70.2-0.2
Time in novel zone, hab. session 10.30.41.31.00.20.3-1.1-0.8-0.4-0.5-0.4-0.30.2
Total zone transitions, hab. session 11.62.23.60.90.61.3-1.7-1.9-1.7-1.9-1.1-1.81.6
Total locomotion distance, hab. session 11.21.83.11.30.30.9-1.7-1.8-1.4-1.6-0.9-1.41.3
Locomotion velocity, hab. session 11.21.72.91.30.51.1-1.6-1.7-1.4-1.6-0.9-1.41.3
Time in familiar zone, hab. session 20.30.30.8-0.7-0.7-0.60.90.40.3-0.00.9-0.10.1
Time in novel zone, hab. session 20.30.30.90.40.3-0.2-0.40.40.50.8-0.11.0-0.9
Total zone transitions, hab. session 22.93.75.61.51.11.6-2.3-2.4-2.0-2.2-1.8-2.01.8
Total locomotion distance, hab. session 23.03.96.02.21.61.7-2.4-2.3-2.0-2.0-1.8-1.81.5
Locomotion velocity, hab. session 22.63.55.82.21.61.6-2.4-2.2-1.8-1.8-1.8-1.61.3
Novel to familiar place preference ratio0.50.72.1-1.4-1.2-0.51.20.30.2-0.20.9-0.40.5
Novelty place preference0.40.51.6-1.3-1.1-0.40.90.20.1-0.20.7-0.40.5
Time in novel zone, NPP test0.40.51.7-1.2-1.3-0.60.80.30.2-0.20.9-0.30.3
Total zone transitions, NPP test0.81.23.51.5-0.30.1-1.9-1.5-0.9-1.3-0.4-1.00.5
Total locomotion distance, NPP test0.81.13.61.90.30.2-1.8-1.4-0.8-1.1-0.4-0.70.4
Locomotion velocity, NPP test1.42.04.72.20.70.7-2.0-1.8-1.3-1.5-0.8-1.20.8
Intraocular pressure0.40.61.80.3-0.2-0.0-0.7-1.1-0.7-1.30.1-1.20.9
Delta distance traveled before/after self-admin0.10.10.30.2-0.4-0.1-0.5-0.4-0.2-0.50.2-0.40.1
Delta ambulatory time before/after self-admin0.30.51.6-1.2-1.3-0.80.30.50.60.20.80.2-0.5
Parametrial fat weight0.92.03.8-1.30.0-0.81.51.91.52.00.71.8-1.5
Pavlov. Cond. lever latency3.44.37.9-1.2-0.6-2.11.42.42.32.61.32.6-2.8
Pavlov. Cond. magazine entry latency0.20.30.7-0.2-0.60.40.3-0.4-0.5-0.70.3-0.80.9
Pavlov. Cond. change in total contacts1.41.53.90.2-0.21.2-0.4-1.4-1.4-1.7-0.4-1.72.0
Pavlov. Cond. index score0.91.12.70.2-0.31.0-0.3-1.2-1.2-1.5-0.2-1.51.7
Pavlov. Cond. latency score1.51.94.50.4-0.01.4-0.6-1.6-1.6-1.9-0.5-1.92.1
Pavlov. Cond. lever contacts3.03.66.30.80.72.1-1.3-2.2-2.2-2.3-1.4-2.32.5
Pavlov. Cond. magazine entry number0.20.20.50.40.7-0.3-0.40.20.30.5-0.40.6-0.6
Pavlov. Cond. intertrial magazine entries0.60.82.0-0.5-1.4-1.01.0-0.20.1-0.81.2-0.80.9
Pavlov. Cond. lever-magazine prob. diff.0.70.92.10.0-0.60.7-0.3-1.1-1.0-1.30.1-1.41.4
Pavlov. Cond. response bias0.30.30.9-0.1-0.60.60.2-0.5-0.6-0.70.1-0.81.0
Pavlov. Cond. lever latency1.21.64.11.22.01.7-1.3-1.0-1.2-0.7-1.5-0.70.7
Pavlov. Cond. magazine entry latency0.10.20.4-0.1-0.2-0.60.20.40.40.40.40.4-0.6
Pavlov. Cond. change in total contacts0.51.32.7-1.3-1.6-1.61.00.91.10.61.50.6-0.7
Pavlov. Cond. index score0.91.43.2-1.3-1.8-1.61.10.91.00.61.40.6-0.8
Pavlov. Cond. latency score0.91.43.0-1.1-1.7-1.61.21.01.10.71.40.7-0.8
Pavlov. Cond. lever contacts0.81.23.7-1.0-1.9-1.60.90.71.00.51.30.6-0.7
Pavlov. Cond. magazine entry number0.00.00.1-0.10.10.30.3-0.0-0.1-0.1-0.0-0.10.3
Pavlov. Cond. intertrial magazine entries0.10.21.0-0.5-1.0-0.60.50.20.30.00.70.0-0.1
Pavlov. Cond. lever-magazine prob. diff.0.91.43.0-1.2-1.7-1.61.11.01.10.71.50.7-0.8
Pavlov. Cond. response bias1.01.43.7-1.2-1.9-1.61.00.91.10.71.40.7-0.8
Time in closed arm before self-admin1.62.84.62.11.01.6-1.6-2.0-1.6-1.9-1.2-1.81.7
Time in closed arm after self-admin1.51.72.61.31.51.6-1.2-1.2-1.3-1.1-1.3-1.21.1
Time in open arm before self-admin0.60.81.40.11.21.1-0.3-0.6-1.1-0.8-1.2-0.90.7
Time in open arm after self-admin0.00.00.2-0.2-0.1-0.20.5-0.0-0.1-0.20.2-0.20.2
Bone: periosteal estimation3.99.320.0-4.2-4.5-3.23.92.42.31.14.00.8-0.8
Bone: periosteal perimeter2.55.011.5-3.3-3.4-2.32.71.61.50.63.00.3-0.5
Bone: post-yield work0.71.34.6-2.2-1.9-1.01.20.60.40.01.2-0.20.0
Progressive ratio test 1 active lever presses1.32.44.31.70.61.3-0.2-1.7-1.7-2.0-1.0-1.92.1
Progressive ratio test 1 breakpoint1.22.13.91.50.51.1-0.1-1.6-1.6-1.9-0.9-1.82.0
Progressive ratio test 1 inactive lever presses0.82.04.20.80.01.10.2-1.5-1.6-2.0-0.8-2.02.0
Progressive ratio test 2 active lever presses0.20.20.60.5-0.20.30.7-0.3-0.4-0.5-0.1-0.50.8
Progressive ratio test 2 breakpoint0.20.20.60.5-0.10.30.7-0.3-0.4-0.5-0.1-0.50.8
Progressive ratio test 2 inactive lever presses0.10.40.80.50.10.50.0-0.5-0.8-0.7-0.6-0.80.9
Incentive Sensitization - Responses0.10.20.8-0.3-0.3-0.20.90.50.40.40.50.30.1
Incentive Sensitization - Breakpoint0.10.31.0-0.4-0.3-0.31.00.60.50.50.50.40.0
Sum of active levers in priming session hrs 5-61.01.02.01.01.01.0-1.4-1.0-0.9-0.8-1.2-0.70.5
Progressive ratio0.10.20.5-0.70.0-0.20.60.60.40.60.10.4-0.5
Food seeking constrained by brief footshock0.30.41.4-1.2-0.5-0.21.00.60.50.40.60.4-0.3
Seeking ratio, punishment vs. effort0.10.20.40.4-0.30.0-0.2-0.5-0.3-0.60.3-0.50.5
Retroperitoneal fat weight2.913.017.42.23.54.2-2.5-3.6-4.2-3.8-3.5-4.04.1
Reaction time number correct0.20.81.3-0.6-0.9-1.00.30.81.11.00.91.1-0.9
Reaction time mean minus median0.10.72.3-0.01.51.40.30.0-0.50.1-1.4-0.10.5
Reaction time mean minus median AUC0.10.71.4-0.70.1-0.21.21.10.91.20.01.1-0.7
Reaction time num false alarms0.61.03.4-0.5-1.8-1.10.2-0.5-0.1-1.11.5-1.00.7
Reaction time num false alarms AUC0.51.14.1-0.8-2.0-1.30.5-0.10.2-0.71.7-0.70.4
Reaction time trials correct on left0.20.81.3-0.6-0.9-1.00.30.81.11.00.91.1-0.9
Reaction time trials on left0.30.91.4-0.7-0.9-1.00.40.91.21.10.91.2-0.9
Reaction time mean0.51.02.3-0.60.3-0.21.31.41.01.5-0.11.4-1.1
Reaction time mean AUC0.30.81.8-0.30.50.11.01.20.71.3-0.41.2-0.9
Median of all reaction times1.01.53.2-0.6-0.1-0.71.31.61.31.80.41.7-1.5
Reaction time omissions0.20.20.6-0.80.3-0.10.60.60.30.6-0.40.5-0.4
Reaction time false alarm rate0.50.71.5-0.3-1.2-0.60.2-0.6-0.5-1.20.9-1.20.8
Reaction time premature initiation rate0.40.61.7-0.1-0.60.0-0.1-0.8-0.7-1.20.3-1.31.1
Reaction time premature initiations0.10.41.5-0.7-1.2-0.80.30.00.2-0.31.0-0.30.2
Std. dev. reaction times0.20.81.6-0.60.90.31.21.20.61.3-0.61.0-0.8
Reaction time trials completed0.30.91.4-0.7-0.9-1.00.40.91.21.10.91.2-0.9
Reaction time trials AUC0.20.81.4-0.6-0.8-1.00.40.91.11.10.91.2-1.0
Run reversals in cocaine runway, females6.77.69.71.82.93.0-2.9-2.7-3.1-2.5-3.1-2.72.5
Run reversals in cocaine runway, males0.20.20.4-0.60.1-0.00.50.60.50.60.10.5-0.4
Latency to leave start box in cocaine runway2.02.89.23.01.81.4-2.1-1.6-1.3-1.2-1.2-0.90.7
Latency to leave start box in cocaine runway, F3.64.510.03.21.91.8-2.7-2.4-2.0-2.1-1.5-1.81.4
Latency to leave start box in cocaine runway, M0.40.31.81.30.80.5-0.4-0.1-0.00.3-0.50.4-0.2
Std. dev. time between licks in bursts0.71.42.81.01.41.2-1.7-1.2-1.2-0.9-1.3-0.80.7
Total sessions with >9 infusions1.21.53.31.80.71.1-0.1-1.3-1.3-1.4-0.9-1.31.5
Short access day 1 total inactive lever presses0.00.10.30.5-0.40.00.6-0.1-0.1-0.2-0.1-0.20.2
Short access day 10 total inactive lever presses0.00.10.2-0.40.20.20.20.2-0.10.1-0.4-0.0-0.1
Short access day 1 total infusions0.51.03.01.70.10.5-0.5-1.2-0.8-1.2-0.2-1.01.2
Short access day 10 total infusions0.91.53.61.1-0.10.70.2-1.3-1.3-1.7-0.3-1.71.9
Short access total infusions0.20.30.70.9-0.5-0.10.5-0.6-0.4-0.80.2-0.60.8
Short access day 1 locomotion2.74.57.12.20.91.7-1.6-2.5-2.3-2.7-1.4-2.52.6
Short access day 10 total locomotion0.41.53.90.30.20.90.3-1.1-1.4-1.7-0.7-1.82.0
Short access total locomotion2.53.86.81.71.01.6-0.7-2.1-2.3-2.5-1.4-2.52.6
One hour access (0.3 mA shock)1.11.33.8-1.2-1.6-1.31.90.90.80.51.20.4-0.3
Compulsive drug intake1.72.54.7-2.0-1.6-1.42.21.61.61.31.91.2-0.6
One hour access (shock baseline)0.00.10.10.0-0.2-0.10.3-0.1-0.3-0.3-0.1-0.40.2
Social response proportion0.30.42.4-1.6-0.6-0.30.60.50.40.30.30.1-0.3
Social responses0.30.30.8-0.3-0.8-0.3-0.3-0.6-0.5-0.90.3-0.90.5
Social time0.30.53.4-1.8-0.2-0.30.60.70.40.50.10.2-0.1
Soleus weight0.31.02.1-0.7-0.21.0-0.4-1.0-1.1-1.2-0.6-1.41.4
Bone: stiffness0.61.13.1-1.4-1.8-1.01.00.80.80.51.40.4-0.6
Tibialis anterior weight2.17.310.70.62.03.3-2.3-2.9-3.1-2.9-2.7-3.03.1
Time to tail flick, vehicle, before self-admin0.60.71.6-1.20.2-0.31.31.20.61.10.00.9-0.5
Time to tail flick, vehicle, after self-admin0.51.01.9-1.4-0.9-0.61.11.21.01.10.81.0-0.4
Time to tail flick, test, before self-admin0.50.62.8-1.7-0.7-0.40.90.50.50.21.00.00.4
Time to tail flick, test, after self-admin0.50.61.6-1.0-0.7-0.71.20.70.60.40.90.3-0.4
Delta time to tail flick, vehicle, before/after SA1.01.11.5-1.0-1.1-1.01.01.11.21.01.21.0-0.7
Delta time to tail flick, test, before/after SA0.91.12.3-0.5-0.5-0.91.51.21.01.10.81.0-1.2
Tibia length0.72.04.20.50.62.00.1-1.3-1.7-1.5-1.4-1.72.1
Ambulatory time before self-admin0.20.61.51.21.11.0-0.8-0.7-0.5-0.4-0.8-0.30.4
Ambulatory time after self-admin0.10.10.70.2-0.20.3-0.8-0.5-0.1-0.3-0.0-0.3-0.0
Bone: tissue strength0.10.10.40.6-0.3-0.4-0.4-0.10.30.20.10.4-0.5
Total heroin consumption0.10.10.4-0.1-0.6-0.3-0.00.10.10.2-0.10.2-0.3
Bone: trabecular number3.36.19.6-2.7-3.1-2.91.32.22.62.32.42.4-2.5
Bone: trabecular spacing1.72.44.91.82.21.8-1.0-1.3-1.6-1.3-1.6-1.41.3
Bone: trabecular thickness1.72.45.1-1.8-2.3-2.01.31.21.40.92.00.9-1.0
Bone: trabecular tissue density0.30.52.01.41.10.8-0.5-0.3-0.5-0.2-0.9-0.20.1
Water consumed over 24 hours1.22.44.62.11.41.4-2.0-1.7-1.6-1.4-1.4-1.20.9
Number of responses in last shaping day1.62.03.31.41.81.8-0.7-1.1-1.5-1.2-1.8-1.31.2