Hub : Genes

Atrip

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression Atrip 0.18 0.13 5.5e-13 0.17 0.16 0.16 0.16 1.9e-13 7.2e-13 1.3e-12 4.2e-13
2 IL gene expression Atrip 0.24 0.15 5.6e-04 0.08 0.06 0.04 0.05 6.4e-03 1.4e-02 4.0e-02 2.9e-02
3 PL gene expression Atrip 0.15 0.08 0.0e+00 0.17 0.17 0.16 0.18 1.4e-18 5.9e-18 1.1e-17 7.4e-19
4 Liver gene expression Atrip 0.08 0.04 3.9e-10 0.08 0.07 0.05 0.08 3.7e-09 1.0e-08 3.6e-06 8.9e-09
5 Brain gene expression Atrip 0.2 0.09 0.0e+00 0.25 0.26 0.25 0.25 4.9e-23 2.9e-24 1.5e-23 2.7e-23
6 IC gene expression Atrip 0.2 0.12 8.6e-09 0.2 0.19 0.21 0.21 4.9e-09 2.4e-08 3.7e-09 4.6e-09
7 Adipose alternative TSS NM_001106859.1 0.02 0.02 2.4e-03 0.02 0.02 0.02 0.01 3.6e-03 2.5e-03 3.4e-03 6.7e-03
8 Adipose alternative TSS NM_001106859.1 0.02 0.02 3.2e-03 0.02 0.02 0.02 0.01 2.8e-03 3.8e-03 3.6e-03 1.0e-02
9 Adipose alternative TSS XM_063265260.1 0.02 0.01 6.6e-03 0.01 0.01 0.01 0.01 7.9e-03 1.2e-02 3.8e-02 2.5e-02
10 BLA gene expression Atrip 0.48 0.21 9.3e-10 0.14 0.12 0.14 0.18 4.4e-08 6.1e-07 7.7e-08 8.6e-10
11 NAcc gene expression Atrip 0.13 0.08 0.0e+00 0.14 0.14 0.15 0.14 3.1e-21 6.0e-20 3.8e-22 1.2e-20
12 LHb alternative polyA NM_001106859.1 0.39 0.19 5.2e-03 0.01 -0.01 -0.01 -0 2.1e-01 7.3e-01 6.2e-01 4.4e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.22.20.0-0.1-0.1-0.20.4-0.1-0.30.1-0.1-0.1-0.0-1.5
Area under the delay curve1.31.52.1-1.4-1.3-1.2-1.2-1.0-1.31.01.3-1.3-1.2-1.5-0.8
BMI with tail0.10.30.70.80.60.70.50.50.4-0.3-0.30.30.30.50.9
BMI without tail0.61.92.61.31.61.61.51.41.4-1.4-1.31.31.31.4-0.6
Body weight4.017.323.44.84.54.64.44.24.4-4.1-4.34.34.23.90.6
Weight adjusted by age0.10.11.0-0.10.10.30.4-0.10.20.1-0.30.30.30.31.0
Bone surface0.10.20.5-0.4-0.3-0.5-0.7-0.4-0.40.40.5-0.5-0.5-0.1-0.1
Bone volume0.10.10.3-0.2-0.2-0.4-0.6-0.1-0.30.10.3-0.3-0.4-0.1-0.6
Breakpoint value in progressive ratio session0.10.10.2-0.2-0.3-0.3-0.3-0.2-0.20.10.3-0.3-0.2-0.4-0.4
Number of licking bursts0.30.52.7-0.7-0.4-0.6-0.6-0.9-0.40.90.3-0.3-0.4-0.31.6
Context. condit. distance diff. score0.00.00.10.00.10.10.0-0.00.10.0-0.10.10.10.00.3
Locomotion velocity, session 10.00.10.2-0.0-0.3-0.1-0.1-0.0-0.30.00.3-0.3-0.2-0.3-0.4
Locomotion distance, session 10.91.21.91.41.11.21.21.30.9-1.2-0.80.80.91.0-0.9
Locomotion velocity, session 20.30.40.5-0.4-0.6-0.5-0.4-0.6-0.70.60.7-0.7-0.7-0.60.6
Locomotion distance, session 20.10.10.50.2-0.10.00.00.2-0.3-0.10.4-0.4-0.4-0.2-0.7
Locomotion velocity, session 30.20.21.10.60.40.30.10.60.2-0.5-0.10.10.10.3-1.0
Locomotion distance, session 30.80.91.3-0.9-0.9-1.0-1.2-0.8-1.10.91.1-1.1-1.2-0.7-0.4
Stereotopy head waving bouts, day 30.20.32.90.00.00.20.2-0.30.10.3-0.20.20.20.01.7
Stereotopy head waving duration, day 30.20.20.60.30.30.50.60.20.5-0.2-0.60.60.60.30.8
Locomotion velocity, session 70.30.32.30.30.30.30.20.70.3-0.7-0.30.30.30.2-1.5
Locomotion distance, session 70.81.11.4-1.0-1.1-1.2-1.2-0.8-1.20.81.1-1.1-1.2-0.9-0.7
Stereotopy head waving bouts, day 70.00.00.10.0-0.00.10.20.10.0-0.1-0.00.00.1-0.1-0.4
Stereotopy head waving duration, day 70.40.50.70.70.70.80.90.80.7-0.8-0.70.70.70.5-0.6
Locomotion velocity, session 80.20.30.60.80.50.60.60.70.3-0.6-0.20.20.30.3-0.7
Locomotion distance, session 80.30.52.00.80.60.70.60.90.3-0.8-0.20.20.20.4-1.4
Degree of sensitization distance1.01.01.30.91.01.01.01.01.1-1.0-1.11.11.11.0-0.4
Degree of sensitization stereotypy0.20.21.50.30.20.30.40.60.2-0.6-0.20.20.30.1-1.2
Conditioned locomotion2.73.14.0-2.0-1.9-1.9-1.9-1.6-1.81.61.8-1.8-1.8-1.7-0.6
Cocaine response after cond. corrected0.40.53.00.50.60.60.60.00.6-0.1-0.60.60.70.61.7
Cocaine response after cond. not corrected1.51.82.31.41.51.51.41.01.5-1.0-1.31.31.51.31.2
Cocaine response before conditioning1.11.31.91.41.31.21.01.41.1-1.3-1.01.01.01.1-1.0
Saline control response0.91.32.61.01.00.90.81.31.0-1.3-1.11.11.01.0-1.6
Bone: connectivity density0.40.63.2-0.7-0.7-0.7-0.7-0.2-0.60.10.6-0.6-0.6-0.5-1.8
Bone: cortical apparent density0.10.20.3-0.4-0.5-0.5-0.4-0.3-0.50.30.5-0.5-0.5-0.4-0.6
Bone: cortical area0.40.63.6-0.5-0.5-0.4-0.4-0.9-0.40.90.4-0.4-0.4-0.41.9
Bone: cortical porosity0.40.44.0-0.5-0.3-0.3-0.30.1-0.2-0.20.2-0.2-0.2-0.2-2.0
Bone: cortical porosity0.40.44.1-0.4-0.3-0.3-0.30.2-0.2-0.20.1-0.1-0.1-0.2-2.0
Bone: cortical thickness0.30.54.70.30.20.30.3-0.30.30.2-0.30.30.30.22.2
Bone: cortical thickness0.00.00.3-0.1-0.2-0.2-0.2-0.2-0.10.20.0-0.0-0.1-0.20.5
Bone: cortical tissue density0.10.20.3-0.4-0.4-0.5-0.4-0.3-0.50.20.5-0.5-0.5-0.3-0.6
Condit. Reinf. active minus inactive responses0.10.10.40.2-0.00.20.40.00.2-0.1-0.30.30.20.00.6
Condit. Reinf. active-inactive response ratio0.20.21.00.40.20.30.50.10.4-0.2-0.50.50.40.21.0
Condit. Reinf. active responses0.00.10.4-0.2-0.1-0.10.0-0.30.00.3-0.10.1-0.0-0.00.6
Condit. Reinf. inactive responses0.30.40.7-0.8-0.5-0.6-0.7-0.7-0.60.70.7-0.7-0.7-0.4-0.1
Incentive salience index mean0.10.10.4-0.2-0.3-0.2-0.1-0.4-0.30.40.2-0.2-0.3-0.20.6
Condit. Reinf. lever presses1.11.52.0-1.2-1.2-1.3-1.4-1.3-1.31.31.3-1.3-1.3-1.00.6
Condit. Reinf. active minus inactive responses1.11.42.21.51.31.21.21.21.2-1.1-1.11.11.11.30.4
Condit. Reinf. active-inactive response ratio1.01.22.01.41.21.21.21.11.1-1.0-1.11.11.01.10.6
Condit. Reinf. active responses0.91.32.11.41.21.21.11.21.2-1.2-1.21.21.11.20.3
Condit. Reinf. inactive responses0.10.10.2-0.3-0.4-0.4-0.4-0.3-0.30.20.2-0.2-0.3-0.30.1
Condit. Reinf. lever presses1.62.23.31.81.61.61.71.51.4-1.5-1.41.41.31.70.1
Condit. Reinf. lever reinforcers received1.21.72.61.61.41.31.31.31.3-1.3-1.41.41.31.30.2
Conditioned reinforcement - actives1.73.04.4-2.1-1.8-1.7-1.7-1.8-1.71.81.8-1.8-1.7-1.70.8
Conditioned reinforcement - inactives2.84.06.1-1.7-2.0-1.8-1.8-2.3-1.92.32.0-2.0-1.8-1.92.5
Conditioned locomotion0.40.51.0-0.9-0.9-0.6-0.6-0.4-0.70.40.7-0.7-0.6-1.0-0.7
Patch foraging indifference point 0 sec1.32.43.31.51.31.51.51.81.6-1.8-1.61.61.71.1-1.7
Patch foraging indifference point AUC0.10.21.40.30.20.20.20.40.1-0.4-0.10.10.0-0.1-1.2
Delay disc. indifference point, 0s delay0.00.00.10.00.10.10.10.10.0-0.1-0.00.00.1-0.0-0.3
Delay disc. indifference point, 16s delay0.80.92.3-1.0-1.2-0.9-0.9-0.7-1.00.70.9-0.9-0.9-1.5-0.5
Delay disc. indifference point, 2s delay0.10.20.3-0.6-0.4-0.4-0.4-0.4-0.40.30.4-0.4-0.3-0.2-0.3
Delay disc. indifference point, 24s delay0.80.91.7-1.1-1.1-0.9-1.0-0.8-1.00.81.0-1.0-0.9-1.3-0.5
Delay disc. indifference point, 4s delay1.21.21.8-1.3-1.1-1.1-1.2-1.1-1.21.11.1-1.1-1.1-1.1-0.0
Delay disc. indifference point, 8s delay1.51.82.3-1.5-1.4-1.4-1.4-1.1-1.41.11.5-1.5-1.4-1.5-0.7
Indifference point function ln k0.30.50.8-0.5-0.7-0.7-0.7-0.7-0.80.70.9-0.9-0.9-0.50.5
Indifference point function log k0.30.50.8-0.5-0.7-0.7-0.7-0.7-0.80.70.9-0.9-0.9-0.50.5
Patch foraging total patch changes 0 sec1.32.53.21.51.41.61.51.71.6-1.8-1.71.71.71.1-1.4
Patch foraging total patch changes 12 sec1.01.21.61.31.11.11.11.21.2-1.2-1.21.21.20.9-0.6
Patch foraging total patch changes 18 sec1.82.73.71.71.31.51.61.91.6-1.9-1.71.71.70.9-1.8
Patch foraging total patch changes 24 sec1.62.74.42.11.61.71.81.81.6-1.8-1.61.61.61.5-0.5
Patch foraging total patch changes 6 sec0.50.73.30.60.30.60.71.00.6-1.0-0.70.70.70.2-1.8
Patch foraging time to switch 0 sec0.20.41.5-0.7-0.6-0.5-0.5-0.8-0.50.80.5-0.5-0.4-0.31.2
Patch foraging water rate 0 sec0.10.30.40.40.70.50.50.50.6-0.5-0.60.60.60.4-0.1
Patch foraging water rate 12 sec0.10.20.40.60.40.60.60.50.4-0.5-0.40.40.40.10.0
Patch foraging water rate 18 sec0.10.21.30.10.50.30.2-0.00.30.1-0.10.10.20.41.1
Patch foraging water rate 24 sec0.71.01.60.81.31.01.10.81.1-0.9-1.11.11.01.20.3
Patch foraging water rate 6 sec0.30.40.80.80.90.60.60.80.6-0.7-0.60.60.60.8-0.4
Seeking ratio, delayed vs. immediate footshock1.31.63.3-1.8-1.2-1.4-1.5-1.3-1.31.21.1-1.1-1.3-1.0-0.7
Distance traveled before self-admin0.60.72.0-0.8-0.7-0.7-0.8-1.0-0.71.00.7-0.7-0.7-0.71.4
Distance traveled after self-admin0.30.40.6-0.7-0.6-0.6-0.6-0.7-0.60.70.7-0.7-0.5-0.50.8
Extensor digitorum longus weight0.20.71.3-0.7-0.7-0.8-1.1-0.9-0.60.90.6-0.6-0.6-0.71.1
Bone: elastic displacement0.10.10.70.20.10.10.1-0.00.2-0.0-0.20.20.2-0.00.8
Bone: elastic work0.30.41.00.60.80.70.60.40.6-0.3-0.60.60.60.71.0
Bone: endosteal estimation0.10.21.30.10.30.20.20.40.3-0.4-0.30.30.30.3-1.1
Bone: endosteal perimeter0.91.92.4-1.5-1.5-1.4-1.3-1.4-1.51.41.5-1.5-1.5-1.40.0
Epididymis fat weight0.20.60.80.80.90.90.90.80.9-0.8-0.80.80.80.70.2
Delta time in closed arm before/after self-admin0.50.50.8-0.5-0.7-0.9-0.9-0.5-0.70.60.7-0.7-0.9-0.7-0.2
Delta time in open arm before/after self-admin0.30.30.40.30.60.60.60.40.6-0.4-0.60.60.60.5-0.0
Diff in mean of infusions in LGA sessions0.30.43.40.40.40.30.3-0.30.40.2-0.30.30.30.71.9
Delay discount exponential model param1.51.62.31.51.41.31.31.11.3-1.1-1.31.31.21.50.8
Extinction: sum of active levers before priming0.10.10.8-0.3-0.2-0.1-0.10.1-0.0-0.10.1-0.1-0.1-0.4-0.9
Active lever presses in extinction session 60.20.21.30.5-0.20.30.30.50.2-0.5-0.10.10.3-0.5-1.1
Bone: final force1.11.82.31.41.51.51.51.01.4-1.0-1.41.41.41.41.1
Bone: final moment1.32.12.61.51.61.61.61.01.5-1.0-1.51.51.51.41.3
Food consumed during 24 hour testing period1.11.52.11.41.31.41.41.31.2-1.2-1.11.11.21.10.1
Glucose1.01.52.01.31.41.11.01.41.2-1.4-1.11.11.01.3-1.2
Heart weight1.42.23.91.61.61.61.71.01.5-0.9-1.41.41.51.42.0
Delay discount hyperbolic model param1.61.82.51.61.41.41.41.21.4-1.2-1.41.41.31.50.6
Intermittent access intake day 1-15 change1.12.23.4-1.2-1.8-1.3-1.3-1.6-1.41.61.4-1.4-1.3-1.81.5
Intermittent access intake escalation1.42.94.1-1.4-2.0-1.5-1.5-1.8-1.71.81.6-1.6-1.5-2.01.7
Intermittent access intake escalation 20.91.03.4-0.5-1.2-0.7-0.7-1.0-0.81.00.8-0.8-0.8-1.31.8
Intermitt. access day 1 inactive lever presses0.10.21.4-0.4-0.3-0.3-0.2-0.5-0.30.50.3-0.3-0.3-0.31.2
Intermitt. access day 15 inactive lever presses1.12.23.4-1.4-1.4-1.3-1.3-1.7-1.41.71.4-1.4-1.4-1.41.9
Intermitt. access escalation Index0.10.11.60.0-0.0-0.0-0.00.3-0.0-0.3-0.00.0-0.00.1-1.2
Intermittent access day 1 total infusions0.30.40.8-0.9-0.8-0.5-0.5-0.7-0.60.60.6-0.6-0.5-0.90.3
Intermittent access day 15 total infusions2.03.04.9-1.7-2.2-1.5-1.5-1.8-1.71.81.6-1.6-1.5-2.21.4
Intermittent access terminal intake (last 3 days)1.41.93.7-1.4-1.8-1.2-1.2-1.4-1.31.41.2-1.2-1.2-1.90.8
Intermittent access total infusions2.02.44.0-1.7-1.9-1.3-1.3-1.7-1.51.61.4-1.4-1.4-2.01.1
Intermittent access day 1 locomotion0.10.10.5-0.0-0.00.30.40.30.3-0.4-0.30.30.3-0.2-0.7
Intermittent access day 15 total locomotion0.61.02.1-0.9-1.5-1.0-0.9-0.9-1.10.91.0-1.0-1.0-1.40.0
Intermittent access total locomotion1.11.32.7-1.2-1.6-1.1-1.0-1.0-1.20.91.1-1.1-1.1-1.6-0.2
Intermittent access standard deviation0.30.65.0-0.1-0.7-0.00.0-0.7-0.20.60.1-0.1-0.1-1.12.2
Left kidney weight0.62.73.61.91.71.81.61.81.7-1.7-1.71.71.71.4-0.3
Right kidney weight0.31.21.61.11.11.21.01.31.2-1.2-1.11.11.20.8-0.5
Cocaine induced anxiety0.30.50.80.40.70.80.80.40.8-0.5-0.80.80.80.90.3
Post-drug Anxiety0.10.10.40.10.40.30.30.10.3-0.1-0.40.40.30.60.1
Baseline Anxiety0.30.40.6-0.5-0.5-0.7-0.7-0.4-0.70.50.7-0.7-0.7-0.4-0.5
Tail length4.417.320.04.24.34.44.44.34.4-4.3-4.54.54.43.8-1.2
Length with tail7.231.539.06.25.96.16.05.66.0-5.5-6.06.05.95.20.3
Length without tail5.317.124.04.94.44.54.44.14.4-4.0-4.34.34.33.71.1
Times rat made contact with spout0.50.60.80.90.80.80.90.70.8-0.7-0.80.80.90.80.3
Lifetime Intake2.42.95.7-1.8-2.2-1.5-1.5-1.7-1.71.61.6-1.6-1.6-2.40.6
Liver weight, left0.61.11.41.11.01.00.81.21.0-1.2-1.11.11.00.9-0.9
Liver weight, right1.73.03.71.71.91.71.71.81.7-1.8-1.71.71.71.7-1.2
Locomotor activity5.18.09.73.12.93.03.12.93.0-2.9-3.03.02.92.7-0.7
Locomotor testing distance3.46.27.42.72.62.72.72.52.6-2.5-2.62.62.62.3-0.5
Locomotor testing rearing0.00.00.00.10.10.00.00.00.1-0.1-0.10.10.20.20.1
Locomotion in novel chamber0.20.21.2-0.2-0.5-0.2-0.2-0.5-0.30.50.3-0.3-0.2-0.71.1
Locomotion in novel chamber post-restriction0.30.51.01.00.50.60.60.90.6-0.9-0.60.60.7-0.1-0.9
Fecal boli incidents, locomotor time 10.50.81.30.60.91.00.80.61.1-0.6-1.11.11.10.90.3
Change in fecal boli incidents, locomotor task0.20.20.4-0.2-0.3-0.5-0.3-0.1-0.60.20.7-0.7-0.7-0.2-0.3
Time >=10cm from walls, locomotor time 10.30.30.7-0.3-0.7-0.5-0.6-0.2-0.60.30.5-0.5-0.5-0.8-0.8
Bouts of movement, locomotor time 10.10.20.60.20.50.30.20.20.4-0.2-0.40.40.40.80.1
Total resting periods, locomotor time 10.10.10.30.20.30.20.10.10.3-0.1-0.30.30.30.50.1
Rest time, locomotor task time 10.50.61.0-0.8-0.6-0.9-1.0-0.8-0.70.80.8-0.8-0.8-0.7-0.1
Distance moved, locomotor task time 10.81.21.71.31.21.11.31.01.1-1.0-1.11.11.01.30.6
Vertical activity count, locomotor time 10.51.21.91.11.31.11.01.01.2-1.0-1.31.31.11.40.1
Time >=10cm from walls, locomotor time 20.81.21.71.31.01.21.01.21.2-1.1-1.21.21.30.4-0.4
Bouts of movement, locomotor time 20.10.20.8-0.3-0.3-0.2-0.1-0.4-0.50.40.6-0.6-0.40.10.9
Total resting periods, locomotor time 20.20.40.7-0.6-0.4-0.5-0.3-0.6-0.70.60.8-0.8-0.6-0.10.7
Rest time, locomotor task time 20.00.00.2-0.30.2-0.2-0.3-0.10.00.1-0.00.0-0.20.1-0.4
Distance moved, locomotor task time 20.60.71.51.20.41.01.00.90.7-0.8-0.70.71.00.30.5
Vertical activity count, locomotor time 20.00.00.10.30.00.20.20.20.2-0.2-0.20.20.30.10.1
Light reinforcement 10.51.11.60.91.01.31.21.01.2-1.0-1.31.31.20.8-0.1
Light reinforcement 20.10.10.8-0.3-0.1-0.2-0.4-0.0-0.20.10.3-0.3-0.3-0.0-0.9
Bone: marrow area0.10.21.40.10.30.30.30.50.4-0.5-0.40.40.30.4-1.2
Bone: maximum diameter0.40.82.4-0.8-0.7-0.7-0.6-1.1-0.71.10.7-0.7-0.7-0.61.5
Bone: maximum force0.71.21.51.11.21.21.10.91.2-0.9-1.21.21.21.10.4
Bone: maximum moment0.71.21.61.11.21.31.20.91.2-0.9-1.21.21.21.00.5
Mean time between licks in bursts0.82.02.4-1.4-1.6-1.5-1.4-1.4-1.51.41.5-1.5-1.5-1.40.5
Mean num. licks in bursts0.81.22.81.20.91.11.11.40.9-1.4-0.80.80.90.8-1.7
Cd content in liver0.10.10.6-0.2-0.3-0.2-0.1-0.1-0.40.10.4-0.4-0.3-0.4-0.8
Co content in liver1.61.82.6-1.4-1.6-1.2-0.9-1.5-1.41.51.3-1.3-1.3-1.51.1
Cu content in liver4.25.06.42.22.52.42.42.22.4-2.2-2.42.42.42.3-0.6
Fe content in liver1.11.31.91.01.11.21.40.91.2-1.0-1.31.31.31.20.4
K content in liver0.40.40.80.50.80.80.90.50.6-0.5-0.60.60.50.6-0.2
Mg content in liver0.50.50.9-0.8-0.5-0.4-0.2-0.8-0.80.90.9-0.9-1.0-0.30.2
Mn content in liver0.20.21.30.30.20.40.60.4-0.1-0.30.1-0.1-0.20.1-1.1
Na content in liver0.70.81.50.60.70.91.20.90.9-0.9-1.01.00.90.5-0.8
Rb content in liver0.50.51.10.40.60.50.60.40.9-0.6-1.11.11.10.60.4
Se content in liver0.10.10.30.40.50.40.50.30.2-0.2-0.10.10.10.60.1
Sr content in liver0.10.10.20.30.10.10.20.1-0.30.10.5-0.5-0.50.1-0.3
Zn content in liver2.42.63.61.61.71.81.91.71.7-1.6-1.71.71.61.4-0.8
Bone: minimum diameter0.51.01.2-1.1-0.9-1.0-1.0-1.1-1.01.11.0-1.0-1.1-0.80.5
Time in familiar zone, hab. session 11.61.52.2-1.5-1.4-1.4-1.3-1.5-1.21.41.1-1.1-1.1-1.20.9
Time in novel zone, hab. session 10.80.81.01.01.01.01.01.00.9-0.9-0.80.80.80.9-0.2
Total zone transitions, hab. session 10.60.81.41.20.81.01.11.20.6-1.1-0.60.60.60.6-1.0
Total locomotion distance, hab. session 10.30.40.70.80.70.70.70.80.6-0.7-0.50.50.50.6-0.6
Locomotion velocity, hab. session 10.40.50.90.90.70.70.70.90.6-0.9-0.60.60.50.6-0.9
Time in familiar zone, hab. session 20.70.81.8-1.0-0.7-0.8-0.7-1.2-0.71.10.7-0.7-0.8-0.61.3
Time in novel zone, hab. session 20.10.11.00.20.10.10.10.40.1-0.4-0.10.10.2-0.0-1.0
Total zone transitions, hab. session 20.10.10.30.60.40.40.40.40.2-0.3-0.10.10.00.30.1
Total locomotion distance, hab. session 20.40.50.80.90.90.80.70.90.7-0.8-0.60.60.60.7-0.5
Locomotion velocity, hab. session 20.30.50.70.80.80.70.70.80.6-0.7-0.50.50.50.7-0.6
Novel to familiar place preference ratio1.61.79.00.81.00.90.91.50.9-1.5-0.90.91.00.9-3.0
Novelty place preference1.71.910.20.71.00.90.91.50.9-1.5-0.90.91.00.9-3.2
Time in novel zone, NPP test1.81.98.90.81.11.01.01.61.1-1.6-1.11.11.11.0-3.0
Total zone transitions, NPP test2.53.65.42.32.12.22.12.21.7-2.1-1.51.51.61.7-1.4
Total locomotion distance, NPP test1.21.62.31.51.41.51.41.41.2-1.3-1.21.21.21.1-0.6
Locomotion velocity, NPP test1.31.92.61.61.51.51.51.61.3-1.5-1.21.21.21.2-0.9
Intraocular pressure1.01.42.10.91.01.01.01.21.2-1.3-1.41.41.30.9-1.3
Delta distance traveled before/after self-admin0.20.20.50.30.30.40.40.40.4-0.4-0.20.20.40.3-0.7
Delta ambulatory time before/after self-admin1.01.21.41.11.11.21.11.21.1-1.2-1.01.01.21.0-0.9
Parametrial fat weight0.71.82.71.41.51.41.41.31.3-1.3-1.31.31.31.70.1
Pavlov. Cond. lever latency4.15.26.22.32.22.42.42.42.4-2.5-2.42.42.51.9-1.3
Pavlov. Cond. magazine entry latency7.19.110.6-3.2-3.1-3.1-3.1-3.2-3.13.23.1-3.1-3.1-2.81.6
Pavlov. Cond. change in total contacts1.81.92.3-1.4-1.5-1.4-1.3-1.5-1.41.51.3-1.3-1.4-1.31.1
Pavlov. Cond. index score6.17.79.3-2.9-2.8-2.9-2.9-3.0-2.83.12.8-2.8-2.9-2.51.9
Pavlov. Cond. latency score5.97.58.9-2.8-2.8-2.8-2.8-3.0-2.83.02.8-2.8-2.9-2.41.7
Pavlov. Cond. lever contacts2.42.83.4-1.6-1.6-1.7-1.8-1.8-1.81.81.8-1.8-1.8-1.31.2
Pavlov. Cond. magazine entry number7.39.210.93.23.23.23.13.33.1-3.3-3.03.03.12.9-1.8
Pavlov. Cond. intertrial magazine entries0.40.40.50.50.70.70.70.60.7-0.7-0.70.70.70.6-0.5
Pavlov. Cond. lever-magazine prob. diff.5.66.98.5-2.6-2.6-2.7-2.7-2.9-2.62.92.6-2.6-2.7-2.32.1
Pavlov. Cond. response bias6.68.29.8-2.9-2.9-2.9-2.9-3.1-2.93.12.9-2.9-3.0-2.62.0
Pavlov. Cond. lever latency0.40.50.9-1.0-0.8-0.8-0.8-0.8-0.70.70.6-0.6-0.6-0.9-0.0
Pavlov. Cond. magazine entry latency0.10.20.3-0.3-0.2-0.3-0.3-0.4-0.40.50.5-0.5-0.5-0.10.5
Pavlov. Cond. change in total contacts1.62.53.81.91.71.82.01.61.6-1.5-1.51.51.51.60.3
Pavlov. Cond. index score0.10.20.40.50.50.50.50.30.3-0.2-0.20.20.20.60.5
Pavlov. Cond. latency score0.10.10.30.40.40.40.40.20.2-0.1-0.10.10.10.50.4
Pavlov. Cond. lever contacts0.60.91.31.21.01.01.01.10.9-1.0-0.80.80.81.0-0.3
Pavlov. Cond. magazine entry number0.20.20.30.40.30.40.40.50.5-0.5-0.50.50.50.2-0.4
Pavlov. Cond. intertrial magazine entries0.60.91.3-1.1-1.2-1.1-1.0-1.0-0.90.90.8-0.8-0.8-1.10.3
Pavlov. Cond. lever-magazine prob. diff.0.10.10.30.50.50.40.40.20.2-0.2-0.10.10.10.60.5
Pavlov. Cond. response bias0.00.00.10.30.20.20.20.10.0-0.10.0-0.0-0.00.30.4
Time in closed arm before self-admin0.40.51.00.80.41.01.00.80.7-0.8-0.70.70.90.20.1
Time in closed arm after self-admin0.40.40.5-0.6-0.6-0.6-0.6-0.6-0.60.60.6-0.6-0.7-0.70.7
Time in open arm before self-admin0.40.50.8-0.9-0.5-0.9-0.9-0.7-0.60.70.5-0.5-0.8-0.40.0
Time in open arm after self-admin0.30.32.6-0.5-0.1-0.3-0.40.0-0.2-0.00.2-0.2-0.3-0.2-1.6
Bone: periosteal estimation0.00.00.1-0.10.10.10.1-0.10.10.1-0.10.10.10.10.3
Bone: periosteal perimeter0.81.41.8-1.3-1.3-1.2-1.2-1.3-1.21.31.2-1.2-1.2-1.20.5
Bone: post-yield work0.00.00.20.10.20.20.00.20.1-0.2-0.10.10.10.1-0.4
Progressive ratio test 1 active lever presses0.10.21.0-0.1-0.6-0.0-0.00.1-0.2-0.10.1-0.1-0.1-1.0-0.8
Progressive ratio test 1 breakpoint0.20.21.0-0.1-0.6-0.0-0.00.1-0.2-0.10.1-0.1-0.1-1.0-0.9
Progressive ratio test 1 inactive lever presses0.60.91.7-0.8-1.1-0.7-0.7-1.0-0.81.00.8-0.8-0.7-1.31.3
Progressive ratio test 2 active lever presses1.82.13.1-1.7-1.7-1.3-1.3-1.5-1.41.51.4-1.4-1.3-1.80.7
Progressive ratio test 2 breakpoint1.82.13.1-1.7-1.7-1.3-1.3-1.6-1.41.51.4-1.4-1.3-1.80.8
Progressive ratio test 2 inactive lever presses2.44.05.6-1.9-2.2-1.7-1.7-2.3-1.82.21.8-1.8-1.7-2.32.4
Incentive Sensitization - Responses1.92.73.5-1.8-1.6-1.6-1.6-1.9-1.61.81.6-1.6-1.6-1.61.5
Incentive Sensitization - Breakpoint2.12.83.6-1.9-1.6-1.6-1.6-1.9-1.61.91.6-1.6-1.6-1.61.5
Sum of active levers in priming session hrs 5-60.30.22.00.2-0.10.30.30.50.2-0.5-0.10.10.2-0.1-1.4
Progressive ratio2.84.35.32.02.12.22.22.22.2-2.2-2.32.32.21.6-1.3
Food seeking constrained by brief footshock1.41.73.2-0.9-1.6-1.4-1.4-1.1-1.41.21.3-1.3-1.3-1.80.3
Seeking ratio, punishment vs. effort4.97.18.4-2.4-2.7-2.8-2.8-2.8-2.82.82.9-2.9-2.8-2.31.5
Retroperitoneal fat weight1.25.16.52.62.32.42.42.42.3-2.3-2.32.32.32.1-0.1
Reaction time number correct0.61.12.1-1.1-1.2-1.1-0.9-1.0-1.10.91.0-1.0-1.0-1.40.4
Reaction time mean minus median0.10.31.00.40.80.50.40.40.5-0.4-0.30.30.41.0-0.3
Reaction time mean minus median AUC0.20.51.10.60.90.70.60.70.7-0.7-0.50.50.71.1-0.7
Reaction time num false alarms0.20.30.5-0.6-0.7-0.6-0.5-0.5-0.50.50.5-0.5-0.5-0.7-0.3
Reaction time num false alarms AUC0.10.10.5-0.3-0.3-0.3-0.2-0.1-0.20.10.2-0.2-0.1-0.3-0.7
Reaction time trials correct on left0.61.12.1-1.1-1.2-1.1-0.9-1.0-1.10.91.0-1.0-1.0-1.40.4
Reaction time trials on left0.61.12.1-1.1-1.2-1.1-0.9-1.0-1.11.01.0-1.0-1.0-1.50.3
Reaction time mean0.00.00.3-0.1-0.00.10.10.1-0.0-0.10.1-0.10.00.2-0.6
Reaction time mean AUC0.10.10.8-0.2-0.1-0.00.00.1-0.1-0.10.2-0.2-0.00.1-0.9
Median of all reaction times0.10.10.4-0.3-0.4-0.2-0.1-0.1-0.20.10.3-0.3-0.2-0.2-0.6
Reaction time omissions0.10.11.0-0.4-0.4-0.3-0.3-0.0-0.2-0.00.1-0.1-0.1-0.3-1.0
Reaction time false alarm rate0.00.00.30.00.10.10.10.10.2-0.1-0.10.10.20.3-0.5
Reaction time premature initiation rate2.12.94.12.01.52.02.01.91.7-1.9-1.71.71.81.3-0.5
Reaction time premature initiations0.61.11.81.30.71.31.41.21.0-1.2-1.11.11.10.4-0.1
Std. dev. reaction times0.20.31.20.30.50.50.50.60.4-0.6-0.30.30.50.7-1.1
Reaction time trials completed0.61.12.1-1.1-1.2-1.1-0.9-1.0-1.11.01.0-1.0-1.0-1.50.3
Reaction time trials AUC0.71.42.6-1.3-1.3-1.2-1.1-1.1-1.21.11.1-1.1-1.2-1.60.4
Run reversals in cocaine runway, females2.12.12.8-1.0-1.5-1.6-1.5-1.4-1.61.51.7-1.7-1.6-1.21.0
Run reversals in cocaine runway, males1.21.31.91.10.91.31.20.81.2-0.9-1.41.41.30.71.0
Latency to leave start box in cocaine runway0.30.30.60.60.60.60.70.50.6-0.5-0.70.70.50.20.2
Latency to leave start box in cocaine runway, F0.70.81.91.00.80.91.00.50.9-0.5-0.90.90.90.61.4
Latency to leave start box in cocaine runway, M0.30.30.6-0.7-0.5-0.6-0.5-0.4-0.50.40.3-0.3-0.6-0.8-0.8
Std. dev. time between licks in bursts4.76.48.3-2.6-2.5-2.6-2.6-2.9-2.52.92.4-2.4-2.5-2.22.3
Total sessions with >9 infusions0.81.02.1-0.9-1.1-0.8-0.8-1.0-0.91.00.9-0.9-0.8-1.51.1
Short access day 1 total inactive lever presses4.76.27.6-2.5-2.6-2.6-2.6-2.5-2.62.52.8-2.8-2.6-2.40.9
Short access day 10 total inactive lever presses0.20.64.20.40.70.50.5-0.20.50.1-0.50.50.40.82.1
Short access day 1 total infusions3.24.36.4-2.2-2.4-2.0-2.0-2.0-2.12.02.2-2.2-2.1-2.50.3
Short access day 10 total infusions2.73.46.2-1.9-2.3-1.8-1.8-1.7-1.91.71.9-1.9-1.8-2.50.2
Short access total infusions4.05.18.5-2.3-2.7-2.3-2.2-2.1-2.42.12.4-2.4-2.3-2.90.1
Short access day 1 locomotion0.50.60.8-0.8-0.9-0.8-0.7-0.8-0.80.80.9-0.9-0.8-0.90.5
Short access day 10 total locomotion0.10.10.60.1-0.50.00.00.2-0.1-0.20.1-0.1-0.0-0.8-0.8
Short access total locomotion0.10.10.6-0.2-0.5-0.1-0.10.0-0.2-0.00.2-0.2-0.1-0.8-0.7
One hour access (0.3 mA shock)1.11.33.9-1.1-1.7-1.0-1.0-0.8-1.10.81.0-1.0-1.0-2.0-0.5
Compulsive drug intake0.91.11.6-0.8-0.9-1.3-1.3-0.7-1.20.81.2-1.2-1.2-0.6-1.1
One hour access (shock baseline)0.40.61.9-0.9-1.2-0.4-0.4-0.8-0.60.70.5-0.5-0.5-1.40.8
Social response proportion0.20.20.30.50.30.40.40.50.4-0.6-0.50.50.50.5-0.1
Social responses0.50.71.20.50.90.80.80.80.8-0.8-0.80.80.81.1-0.6
Social time0.60.82.9-0.9-0.8-0.6-0.7-1.0-0.71.00.6-0.6-0.7-0.71.7
Soleus weight3.610.713.13.63.63.63.43.23.5-3.2-3.43.43.43.2-0.1
Bone: stiffness0.20.30.40.50.60.60.60.50.6-0.5-0.60.60.60.50.0
Tibialis anterior weight0.00.11.40.20.20.2-0.0-0.10.20.1-0.20.20.30.11.2
Time to tail flick, vehicle, before self-admin1.21.21.51.11.11.11.21.21.1-1.2-1.21.21.11.1-0.3
Time to tail flick, vehicle, after self-admin0.40.50.80.70.50.90.90.40.7-0.4-0.70.70.80.80.8
Time to tail flick, test, before self-admin0.30.32.50.30.20.30.30.60.3-0.6-0.20.20.3-0.2-1.6
Time to tail flick, test, after self-admin0.20.20.4-0.6-0.4-0.3-0.3-0.5-0.30.40.5-0.5-0.3-0.30.6
Delta time to tail flick, vehicle, before/after SA0.20.20.5-0.4-0.3-0.2-0.2-0.6-0.40.60.4-0.4-0.3-0.20.7
Delta time to tail flick, test, before/after SA0.40.40.8-0.9-0.6-0.5-0.5-0.7-0.60.70.6-0.6-0.6-0.30.8
Tibia length6.016.521.54.64.64.54.34.14.2-4.0-4.04.04.04.3-0.3
Ambulatory time before self-admin1.11.61.9-1.2-1.4-1.2-1.2-1.4-1.21.41.2-1.2-1.2-1.31.3
Ambulatory time after self-admin0.10.10.2-0.3-0.4-0.2-0.2-0.2-0.20.20.3-0.3-0.2-0.40.0
Bone: tissue strength2.52.53.11.71.71.71.71.31.7-1.4-1.71.71.71.60.8
Total heroin consumption1.61.92.61.51.31.61.51.01.5-1.0-1.41.41.61.21.1
Bone: trabecular number0.81.32.5-1.0-1.2-1.3-1.4-0.6-1.20.61.2-1.2-1.2-1.0-1.6
Bone: trabecular spacing1.62.12.91.41.51.61.70.91.5-0.9-1.61.61.61.31.6
Bone: trabecular thickness0.20.32.40.30.20.20.00.60.1-0.6-0.10.10.10.2-1.6
Bone: trabecular tissue density0.50.70.90.90.91.00.90.90.9-0.9-0.90.90.90.6-0.3
Water consumed over 24 hours0.20.22.00.30.30.30.3-0.10.20.1-0.20.20.20.41.4
Number of responses in last shaping day0.50.63.3-0.7-0.5-0.4-0.4-0.9-0.40.90.5-0.5-0.4-0.31.8