Hub : Genes

Atp6v1d

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain mRNA stability Atp6v1d 0.07 0.05 6.9e-03 0.01 0.02 0.01 0.01 2.6e-02 2.6e-03 7.0e-02 1.2e-02
2 Liver gene expression Atp6v1d 0.1 0.05 1.7e-10 0.07 0.09 0.09 0.06 1.9e-08 2.5e-10 1.5e-10 8.8e-07
3 OFC gene expression Atp6v1d 0.54 0.14 1.8e-10 0.32 0.36 0.33 0.32 1.7e-08 2.0e-09 1.2e-08 1.6e-08
4 Brain gene expression Atp6v1d 0.6 0.11 0.0e+00 0.55 0.59 0.6 0.59 1.2e-61 1.8e-68 5.2e-69 1.4e-68
5 PL gene expression Atp6v1d 0.32 0.1 0.0e+00 0.34 0.37 0.35 0.35 3.7e-38 7.1e-42 8.5e-40 1.6e-39
6 BLA gene expression Atp6v1d 0.55 0.15 0.0e+00 0.28 0.3 0.26 0.3 2.3e-15 5.0e-16 2.9e-14 2.0e-16
7 LHb gene expression Atp6v1d 0.47 0.15 3.9e-08 0.38 0.34 0.31 0.33 5.9e-10 5.3e-09 4.7e-08 1.1e-08
8 IL gene expression Atp6v1d 0.73 0.12 2.5e-15 0.36 0.42 0.4 0.42 1.2e-09 2.4e-11 1.1e-10 2.1e-11
9 NAcc gene expression Atp6v1d 0.2 0.08 0.0e+00 0.2 0.21 0.2 0.2 7.0e-29 4.5e-31 1.3e-29 9.0e-30
10 IC gene expression Atp6v1d 0.54 0.13 0.0e+00 0.46 0.47 0.42 0.48 4.2e-21 1.1e-21 4.6e-19 2.9e-22
11 pVTA gene expression Atp6v1d 0.52 0.15 0.0e+00 0.3 0.34 0.35 0.35 4.7e-24 1.3e-28 7.5e-29 8.6e-29
12 Adipose gene expression Atp6v1d 0.11 0.06 8.3e-13 0.06 0.1 0.1 0.1 6.0e-07 1.3e-11 5.5e-11 2.6e-11
13 Liver mRNA stability Atp6v1d 0.04 0.03 7.9e-05 0.01 0.03 0.02 0.02 3.3e-02 1.8e-04 1.7e-03 3.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.91.62.9-1.0-1.7-1.4-1.4-1.4-1.2-1.5-1.4-1.3-1.3-0.8-1.1-0.1
Area under the delay curve0.00.00.3-0.5-0.3-0.1-0.1-0.10.1-0.0-0.10.0-0.00.40.10.2
BMI with tail1.13.78.3-2.01.61.91.82.02.01.81.72.22.02.91.90.4
BMI without tail0.20.65.5-2.3-0.8-0.0-0.20.10.1-0.5-0.20.20.11.3-0.1-0.3
Body weight0.93.723.0-4.8-0.91.51.01.61.50.40.91.41.32.6-0.3-2.2
Weight adjusted by age0.60.93.8-1.9-1.4-0.5-0.7-0.5-0.7-1.0-0.8-0.7-0.5-0.4-1.1-1.1
Bone surface1.83.35.2-0.5-2.1-2.3-2.3-2.1-1.9-2.0-2.1-1.9-2.1-1.2-1.50.3
Bone volume2.03.66.9-1.2-2.6-2.1-2.1-1.9-1.8-2.1-2.1-1.9-2.0-1.2-2.1-0.7
Breakpoint value in progressive ratio session0.60.86.3-2.5-1.00.3-0.00.20.1-0.5-0.10.10.10.5-0.6-1.2
Number of licking bursts1.01.711.73.41.3-0.7-0.4-0.7-0.60.2-0.2-0.4-0.5-1.30.82.0
Context. condit. distance diff. score2.83.45.1-1.51.42.31.92.22.11.82.02.02.12.11.3-0.6
Locomotion velocity, session 11.21.32.30.4-1.0-1.5-1.4-1.4-1.3-1.1-1.3-1.1-1.2-1.1-0.70.4
Locomotion distance, session 11.31.73.41.31.91.01.01.01.11.61.21.21.21.11.71.4
Locomotion velocity, session 20.10.20.60.70.50.30.20.40.20.40.40.40.40.10.50.4
Locomotion distance, session 20.40.53.11.71.10.20.20.30.30.80.50.30.30.00.80.9
Locomotion velocity, session 30.40.43.20.4-0.50.20.10.1-0.00.00.1-0.3-0.1-0.8-1.2-1.8
Locomotion distance, session 30.50.61.50.8-0.6-0.5-0.5-0.5-0.6-0.3-0.5-0.8-0.7-1.1-1.2-1.1
Stereotopy head waving bouts, day 31.01.23.7-1.9-1.9-0.4-0.9-0.3-0.4-0.8-0.8-0.8-0.70.0-1.6-1.6
Stereotopy head waving duration, day 30.40.52.0-1.2-1.2-0.0-0.40.0-0.1-0.3-0.3-0.4-0.30.0-1.1-1.4
Locomotion velocity, session 71.21.42.30.00.91.51.21.51.41.41.41.11.31.10.3-1.0
Locomotion distance, session 71.41.73.00.41.71.31.21.31.21.21.41.41.41.61.60.9
Stereotopy head waving bouts, day 70.80.93.9-2.0-1.40.2-0.20.20.1-0.3-0.2-0.2-0.10.2-1.3-2.0
Stereotopy head waving duration, day 71.01.25.6-2.3-1.50.3-0.00.30.2-0.2-0.1-0.10.00.2-1.4-2.4
Locomotion velocity, session 81.41.63.2-1.40.91.31.21.31.41.21.21.51.51.81.20.2
Locomotion distance, session 82.84.15.8-0.22.12.32.12.42.22.42.32.22.32.11.7-0.0
Degree of sensitization distance1.61.73.6-0.31.51.11.11.11.10.91.21.41.31.71.91.5
Degree of sensitization stereotypy0.50.52.5-1.4-0.90.30.10.40.2-0.00.10.10.20.2-0.8-1.6
Conditioned locomotion0.50.62.81.7-0.2-0.4-0.7-0.4-0.7-0.0-0.5-0.8-0.7-1.1-0.9-0.5
Cocaine response after cond. corrected2.22.64.20.71.71.92.11.91.91.91.91.71.81.21.0-0.7
Cocaine response after cond. not corrected3.23.85.60.21.92.12.42.22.32.22.22.22.12.01.5-0.3
Cocaine response before conditioning0.30.31.4-0.90.10.10.10.30.40.20.20.60.31.20.80.7
Saline control response0.30.41.60.00.50.10.20.30.40.20.40.50.41.01.01.2
Bone: connectivity density0.00.10.5-0.7-0.4-0.2-0.1-0.2-0.1-0.1-0.2-0.1-0.1-0.0-0.1-0.0
Bone: cortical apparent density2.73.75.62.1-0.8-2.0-2.1-2.2-2.2-1.7-2.0-2.2-2.1-2.4-0.71.5
Bone: cortical area0.40.61.40.4-0.9-0.8-0.5-0.6-0.5-0.4-0.5-0.6-0.8-1.0-1.2-1.1
Bone: cortical porosity0.30.41.6-1.3-0.10.70.60.60.60.20.50.50.60.80.2-0.4
Bone: cortical porosity0.20.21.2-1.1-0.20.40.30.30.30.10.30.30.30.50.0-0.4
Bone: cortical thickness0.91.53.11.01.41.21.41.21.41.81.51.21.20.40.7-0.4
Bone: cortical thickness2.73.26.82.52.61.61.61.71.52.32.01.61.60.61.70.7
Bone: cortical tissue density2.83.85.72.1-0.8-2.0-2.2-2.2-2.3-1.8-2.1-2.3-2.1-2.4-0.71.5
Condit. Reinf. active minus inactive responses0.50.62.6-1.60.21.00.80.70.70.20.60.60.70.60.2-0.7
Condit. Reinf. active-inactive response ratio0.20.20.6-0.8-0.50.1-0.2-0.2-0.3-0.5-0.3-0.4-0.3-0.6-0.6-0.8
Condit. Reinf. active responses0.60.71.3-1.00.81.11.00.80.80.60.90.91.00.60.8-0.0
Condit. Reinf. inactive responses1.41.73.9-0.11.81.11.11.01.11.11.21.31.41.32.01.5
Incentive salience index mean0.60.81.9-1.40.61.21.00.80.90.50.90.90.90.60.5-0.6
Condit. Reinf. lever presses0.10.20.8-0.90.40.50.50.30.40.20.40.50.50.20.3-0.2
Condit. Reinf. active minus inactive responses0.91.27.90.31.30.10.30.00.40.20.40.60.50.82.12.8
Condit. Reinf. active-inactive response ratio0.40.43.60.30.5-0.3-0.1-0.3-0.1-0.2-0.00.1-0.00.11.21.9
Condit. Reinf. active responses0.30.43.3-0.40.2-0.4-0.3-0.4-0.1-0.5-0.2-0.0-0.10.51.01.8
Condit. Reinf. inactive responses0.10.10.2-0.4-0.5-0.2-0.4-0.3-0.2-0.3-0.2-0.3-0.30.0-0.3-0.1
Condit. Reinf. lever presses1.21.73.1-1.4-1.8-1.2-1.4-1.3-1.2-1.6-1.4-1.4-1.3-0.8-1.1-0.1
Condit. Reinf. lever reinforcers received0.30.53.7-0.50.2-0.3-0.3-0.4-0.1-0.5-0.2-0.0-0.10.51.11.9
Conditioned reinforcement - actives1.32.23.00.01.71.61.71.61.61.61.71.71.61.41.40.2
Conditioned reinforcement - inactives1.11.62.91.11.71.11.21.31.21.41.41.31.20.91.40.7
Conditioned locomotion1.52.02.90.51.71.51.71.51.61.61.61.61.41.11.30.1
Patch foraging indifference point 0 sec1.12.04.4-0.6-1.1-1.6-2.1-1.5-1.7-1.5-1.7-1.4-1.4-0.9-0.31.4
Patch foraging indifference point AUC0.00.00.1-0.2-0.1-0.1-0.1-0.2-0.1-0.4-0.1-0.1-0.10.10.00.2
Delay disc. indifference point, 0s delay0.70.73.9-0.01.00.20.20.10.20.20.30.60.51.11.62.0
Delay disc. indifference point, 16s delay0.60.61.20.1-1.1-0.8-0.9-0.7-0.7-0.4-0.8-0.9-0.8-0.8-1.0-0.5
Delay disc. indifference point, 2s delay0.91.02.2-1.40.61.01.00.91.10.60.91.21.11.51.10.3
Delay disc. indifference point, 24s delay0.00.00.20.4-0.1-0.1-0.2-0.1-0.10.0-0.1-0.2-0.1-0.3-0.10.1
Delay disc. indifference point, 4s delay0.40.40.70.6-0.6-0.8-0.6-0.9-0.7-0.7-0.7-0.7-0.8-0.7-0.50.1
Delay disc. indifference point, 8s delay0.20.32.2-1.5-0.30.10.10.10.30.0-0.00.30.20.90.30.1
Indifference point function ln k0.00.10.3-0.50.1-0.10.00.00.1-0.00.00.20.10.40.40.4
Indifference point function log k0.00.10.3-0.50.1-0.10.00.00.1-0.00.00.20.10.40.40.4
Patch foraging total patch changes 0 sec1.12.04.3-0.6-1.0-1.6-2.1-1.5-1.7-1.5-1.7-1.4-1.4-0.9-0.11.6
Patch foraging total patch changes 12 sec0.60.81.8-1.0-1.1-0.9-1.3-0.8-1.0-1.0-1.0-0.9-0.9-0.5-0.8-0.1
Patch foraging total patch changes 18 sec1.01.63.1-0.9-1.5-1.4-1.8-1.3-1.3-1.6-1.3-1.4-1.3-0.4-0.70.7
Patch foraging total patch changes 24 sec0.50.91.8-1.1-1.3-0.7-1.3-0.7-1.0-1.0-1.0-1.1-0.9-0.6-0.9-0.3
Patch foraging total patch changes 6 sec0.91.42.8-0.0-1.0-1.4-1.7-1.3-1.4-1.3-1.4-1.2-1.2-0.8-0.40.9
Patch foraging time to switch 0 sec0.40.94.90.4-1.1-0.1-0.3-0.1-0.30.0-0.3-0.7-0.4-1.0-1.8-2.2
Patch foraging water rate 0 sec0.51.02.5-1.40.90.70.60.70.70.40.61.00.91.41.61.3
Patch foraging water rate 12 sec0.30.72.2-0.80.90.40.50.30.60.20.60.80.61.01.51.4
Patch foraging water rate 18 sec1.82.86.1-2.51.02.01.81.81.81.51.61.81.81.81.2-0.6
Patch foraging water rate 24 sec1.92.65.2-2.01.41.51.31.31.41.01.41.71.62.32.21.4
Patch foraging water rate 6 sec0.30.53.1-1.8-0.9-0.5-0.5-0.5-0.3-0.9-0.4-0.2-0.30.4-0.00.2
Seeking ratio, delayed vs. immediate footshock0.20.21.31.10.3-0.2-0.3-0.2-0.30.1-0.1-0.3-0.1-0.70.10.5
Distance traveled before self-admin0.50.71.3-0.11.00.70.80.80.70.71.00.90.81.11.00.5
Distance traveled after self-admin0.40.52.1-1.2-0.20.80.70.70.70.30.60.60.50.5-0.4-1.5
Extensor digitorum longus weight0.20.62.5-1.2-0.10.60.80.91.00.20.60.80.71.60.4-0.2
Bone: elastic displacement0.80.91.71.11.30.71.10.70.91.11.00.90.90.61.10.7
Bone: elastic work2.32.94.7-0.41.71.82.21.72.01.92.02.01.91.51.70.1
Bone: endosteal estimation3.16.811.3-0.6-3.4-2.9-2.8-2.5-2.7-3.0-2.7-2.7-2.8-2.3-3.0-1.3
Bone: endosteal perimeter2.34.97.5-0.4-2.7-2.6-2.3-2.2-2.3-2.4-2.4-2.2-2.4-2.0-2.5-1.1
Epididymis fat weight0.10.20.7-0.9-0.10.50.20.40.40.40.40.10.20.1-0.3-0.8
Delta time in closed arm before/after self-admin0.10.10.40.5-0.0-0.2-0.0-0.2-0.2-0.2-0.1-0.2-0.1-0.7-0.3-0.2
Delta time in open arm before/after self-admin0.40.41.8-1.3-0.00.40.40.30.60.10.30.50.41.20.70.6
Diff in mean of infusions in LGA sessions0.10.20.9-1.00.0-0.1-0.2-0.1-0.1-0.2-0.20.10.10.40.60.8
Delay discount exponential model param0.00.00.20.50.30.10.10.1-0.10.00.1-0.00.0-0.3-0.0-0.1
Extinction: sum of active levers before priming1.21.35.0-2.1-1.8-0.1-0.1-0.2-0.1-1.2-0.4-0.4-0.4-0.0-1.6-2.2
Active lever presses in extinction session 61.41.43.4-1.8-1.8-0.7-0.8-0.8-0.8-1.6-1.1-0.9-0.9-0.2-1.4-1.2
Bone: final force1.52.43.5-1.70.71.91.71.81.81.41.81.61.71.50.5-1.4
Bone: final moment1.01.63.1-1.80.41.51.31.41.41.01.41.31.31.20.4-1.2
Food consumed during 24 hour testing period0.30.51.1-0.80.20.70.70.70.90.40.70.70.71.10.3-0.3
Glucose0.50.83.81.90.2-0.8-0.7-0.9-0.9-0.5-0.6-0.8-0.8-1.2-0.10.9
Heart weight1.21.93.0-0.5-1.5-1.6-1.7-1.5-1.5-1.6-1.6-1.5-1.6-0.9-1.00.4
Delay discount hyperbolic model param0.10.10.40.60.1-0.1-0.2-0.1-0.3-0.1-0.1-0.2-0.2-0.5-0.2-0.1
Intermittent access intake day 1-15 change0.91.84.01.52.00.81.10.81.01.31.21.31.01.02.01.8
Intermittent access intake escalation0.81.63.41.41.90.71.00.81.01.31.11.20.90.91.81.7
Intermittent access intake escalation 20.30.41.41.20.90.40.60.40.50.80.60.50.40.00.50.2
Intermitt. access day 1 inactive lever presses0.00.10.2-0.10.10.0-0.10.10.0-0.20.20.20.20.50.40.4
Intermitt. access day 15 inactive lever presses1.02.12.9-0.71.21.61.71.61.71.31.61.71.61.61.2-0.2
Intermitt. access escalation Index0.10.10.6-0.8-0.30.30.40.10.3-0.10.20.20.30.1-0.1-0.6
Intermittent access day 1 total infusions0.20.31.60.2-0.7-0.1-0.2-0.0-0.2-0.2-0.1-0.3-0.3-0.6-1.0-1.2
Intermittent access day 15 total infusions0.50.71.71.31.20.60.90.70.81.00.90.80.70.41.00.6
Intermittent access terminal intake (last 3 days)0.10.10.30.60.20.20.40.30.30.20.50.30.3-0.1-0.1-0.5
Intermittent access total infusions0.10.10.70.80.40.00.30.10.20.20.30.30.10.20.30.3
Intermittent access day 1 locomotion0.10.10.4-0.3-0.5-0.0-0.0-0.10.1-0.30.0-0.1-0.0-0.1-0.4-0.6
Intermittent access day 15 total locomotion0.20.40.70.50.80.50.70.50.60.60.70.70.60.60.90.6
Intermittent access total locomotion0.60.71.2-0.40.60.91.10.91.10.91.01.00.90.90.6-0.3
Intermittent access standard deviation0.10.21.01.00.0-0.5-0.5-0.3-0.50.0-0.3-0.4-0.5-0.4-0.10.4
Left kidney weight0.10.53.4-1.1-0.90.2-0.00.30.20.1-0.0-0.00.0-0.1-1.1-1.8
Right kidney weight0.21.05.7-0.0-1.3-0.4-0.5-0.1-0.4-0.2-0.4-0.7-0.6-0.8-2.0-2.4
Cocaine induced anxiety3.24.66.90.42.22.32.62.42.52.22.52.42.32.01.7-0.2
Post-drug Anxiety1.81.93.00.71.61.41.71.41.61.61.51.51.41.31.1-0.1
Baseline Anxiety1.41.62.40.3-1.2-1.5-1.5-1.5-1.5-1.1-1.5-1.5-1.5-1.2-1.20.1
Tail length0.52.06.1-2.5-2.4-0.5-0.9-0.3-0.6-1.4-0.8-0.8-0.6-0.1-2.0-2.3
Length with tail0.83.518.8-4.3-2.60.50.10.60.4-0.9-0.00.00.10.8-2.1-3.7
Length without tail0.41.47.8-2.8-1.60.30.00.30.3-0.5-0.0-0.00.00.5-1.4-2.4
Times rat made contact with spout0.50.61.8-1.3-1.2-0.5-0.6-0.5-0.4-0.8-0.7-0.5-0.50.2-1.0-0.8
Lifetime Intake0.00.10.60.80.2-0.10.1-0.10.1-0.10.20.1-0.1-0.00.20.3
Liver weight, left0.30.41.4-1.2-1.0-0.6-0.6-0.6-0.5-0.8-0.6-0.5-0.5-0.2-0.5-0.1
Liver weight, right0.30.51.61.2-0.5-0.9-0.7-0.7-0.7-0.5-0.5-0.8-0.8-0.9-0.50.2
Locomotor activity1.42.29.7-3.1-0.21.61.21.41.40.71.01.21.21.8-0.0-1.7
Locomotor testing distance0.51.03.8-1.90.11.30.91.01.00.60.70.70.81.00.0-1.1
Locomotor testing rearing0.30.64.1-2.0-1.00.1-0.2-0.1-0.0-0.4-0.3-0.2-0.20.3-0.8-1.1
Locomotion in novel chamber0.70.81.60.9-0.8-1.0-0.8-0.9-0.9-0.7-0.8-1.0-1.0-1.3-1.0-0.4
Locomotion in novel chamber post-restriction0.30.42.8-1.1-0.70.20.30.10.20.20.10.00.1-0.2-0.9-1.7
Fecal boli incidents, locomotor time 11.72.53.4-0.31.51.81.81.81.81.51.71.81.81.81.3-0.2
Change in fecal boli incidents, locomotor task1.31.22.51.6-0.8-1.1-1.2-0.9-1.2-0.7-0.9-1.2-1.2-1.5-1.3-0.5
Time >=10cm from walls, locomotor time 12.12.23.3-1.40.81.81.61.81.71.41.61.61.61.60.6-1.2
Bouts of movement, locomotor time 13.03.45.1-0.4-2.3-2.0-2.0-2.0-2.0-2.2-2.0-2.0-2.0-1.4-2.0-0.5
Total resting periods, locomotor time 13.03.34.7-0.1-2.2-2.0-2.0-2.0-2.0-2.2-2.0-2.0-2.0-1.5-1.9-0.5
Rest time, locomotor task time 10.60.71.10.7-0.8-1.0-1.0-0.9-1.0-0.9-0.9-1.0-1.0-0.6-0.80.0
Distance moved, locomotor task time 10.30.50.7-0.80.70.80.70.70.70.70.70.80.80.30.70.0
Vertical activity count, locomotor time 10.92.22.90.11.71.61.61.71.61.71.61.71.71.11.60.4
Time >=10cm from walls, locomotor time 24.97.29.7-0.72.63.03.13.03.13.13.03.13.02.72.3-0.3
Bouts of movement, locomotor time 22.23.55.40.8-1.7-2.3-2.1-2.3-2.1-2.3-2.1-2.1-2.1-1.3-1.01.2
Total resting periods, locomotor time 22.54.46.81.1-1.7-2.6-2.4-2.6-2.4-2.5-2.3-2.3-2.4-1.6-1.11.4
Rest time, locomotor task time 20.81.05.82.40.7-0.7-0.6-0.7-0.8-0.2-0.5-0.6-0.7-0.90.51.6
Distance moved, locomotor task time 20.60.73.0-1.70.10.90.80.80.80.40.70.90.90.90.3-0.7
Vertical activity count, locomotor time 20.71.01.4-0.60.81.11.11.11.21.11.11.21.11.10.8-0.1
Light reinforcement 11.12.711.6-3.40.41.61.61.41.60.71.21.71.62.10.8-1.0
Light reinforcement 20.81.32.4-1.21.01.21.61.01.41.01.01.31.21.21.0-0.2
Bone: marrow area3.37.212.0-0.7-3.5-2.9-2.9-2.6-2.8-3.1-2.8-2.8-2.9-2.3-3.0-1.3
Bone: maximum diameter2.64.97.70.6-2.5-2.8-2.5-2.3-2.4-2.1-2.4-2.2-2.5-2.3-2.4-0.8
Bone: maximum force0.81.36.4-1.3-0.31.11.01.21.10.91.10.90.90.5-0.8-2.5
Bone: maximum moment0.50.85.1-1.3-0.60.70.50.70.70.40.60.40.50.1-1.0-2.3
Mean time between licks in bursts0.20.54.52.10.4-0.1-0.1-0.2-0.30.2-0.1-0.5-0.3-1.1-0.3-0.0
Mean num. licks in bursts1.42.214.8-3.8-1.80.50.10.50.5-0.6-0.10.10.31.3-1.3-2.4
Cd content in liver0.50.60.9-0.30.80.90.71.00.70.90.90.90.90.70.7-0.0
Co content in liver1.82.13.7-0.8-1.9-1.3-1.6-1.1-1.6-1.5-1.5-1.4-1.4-1.5-1.8-1.2
Cu content in liver1.01.21.9-0.21.31.01.11.01.11.01.11.21.21.21.40.7
Fe content in liver3.94.77.00.9-1.8-2.6-2.6-2.6-2.6-2.3-2.4-2.4-2.4-2.1-1.50.8
K content in liver0.30.20.7-0.1-0.5-0.5-0.4-0.6-0.5-0.5-0.5-0.5-0.5-0.8-0.4-0.2
Mg content in liver2.42.43.80.9-1.1-1.8-1.8-1.9-1.8-1.6-1.7-1.8-1.7-1.9-0.90.7
Mn content in liver3.43.85.00.6-1.9-2.2-2.2-2.2-2.2-2.2-2.1-2.2-2.2-2.2-1.60.1
Na content in liver0.60.60.9-0.9-0.9-0.9-0.8-1.0-0.9-0.9-0.9-0.7-0.7-0.4-0.7-0.1
Rb content in liver1.11.32.51.60.0-1.3-1.3-1.2-1.3-0.7-1.1-1.0-1.0-1.50.21.5
Se content in liver0.10.10.80.20.3-0.0-0.30.0-0.00.10.00.00.00.00.60.9
Sr content in liver0.70.61.1-0.20.81.00.81.00.71.00.90.80.90.70.6-0.2
Zn content in liver0.70.72.31.10.3-0.8-0.7-1.0-0.9-0.8-0.6-0.7-0.6-1.10.41.5
Bone: minimum diameter4.27.612.1-0.3-3.5-3.0-2.8-2.7-2.8-3.0-2.8-2.8-2.9-2.7-3.3-1.7
Time in familiar zone, hab. session 12.92.84.41.2-1.2-1.8-1.6-2.0-1.8-1.9-1.8-2.0-1.9-2.1-1.10.5
Time in novel zone, hab. session 12.52.53.7-1.40.91.71.71.91.81.61.71.81.81.90.8-0.9
Total zone transitions, hab. session 10.81.11.80.20.81.21.11.31.31.31.21.01.11.20.5-0.5
Total locomotion distance, hab. session 11.52.23.91.21.61.61.51.81.72.01.71.41.51.21.0-0.2
Locomotion velocity, hab. session 11.42.03.41.31.61.51.41.71.51.91.61.31.41.11.10.1
Time in familiar zone, hab. session 20.80.82.0-1.0-1.2-0.9-0.9-1.0-0.9-1.4-1.0-0.9-0.8-0.4-0.70.0
Time in novel zone, hab. session 22.22.23.40.61.81.51.61.61.61.91.71.61.61.11.40.2
Total zone transitions, hab. session 21.11.43.1-0.61.01.21.01.31.31.21.21.31.31.81.10.3
Total locomotion distance, hab. session 21.82.43.50.21.81.51.51.61.61.91.61.71.61.81.70.7
Locomotion velocity, hab. session 21.52.03.20.21.61.41.41.61.51.81.51.51.51.71.40.5
Novel to familiar place preference ratio0.80.91.70.70.51.11.01.31.01.31.10.80.90.6-0.1-1.3
Novelty place preference0.60.62.30.50.10.80.71.10.81.00.80.60.60.4-0.5-1.5
Time in novel zone, NPP test0.70.71.60.50.30.90.81.20.91.11.00.70.80.7-0.2-1.2
Total zone transitions, NPP test1.01.43.5-0.91.01.10.81.31.21.31.01.31.21.91.30.6
Total locomotion distance, NPP test2.22.94.9-1.11.21.91.62.12.02.11.81.91.92.21.1-0.6
Locomotion velocity, NPP test1.92.64.3-1.01.11.91.62.11.92.01.71.81.81.90.7-1.0
Intraocular pressure3.44.97.80.42.82.42.22.52.32.72.42.32.42.02.30.7
Delta distance traveled before/after self-admin0.50.52.7-1.6-1.1-0.1-0.2-0.2-0.2-0.7-0.5-0.3-0.2-0.1-0.8-1.1
Delta ambulatory time before/after self-admin0.30.41.8-1.4-1.0-0.2-0.3-0.3-0.2-0.6-0.5-0.4-0.3-0.2-0.8-0.9
Parametrial fat weight0.10.10.7-0.4-0.6-0.2-0.0-0.2-0.0-0.2-0.1-0.1-0.2-0.0-0.6-0.8
Pavlov. Cond. lever latency0.60.81.50.50.41.21.01.21.11.11.00.60.80.5-0.1-1.2
Pavlov. Cond. magazine entry latency0.70.94.1-2.0-1.2-0.7-0.8-0.8-0.7-1.0-0.9-0.6-0.6-0.1-0.9-0.6
Pavlov. Cond. change in total contacts0.91.06.0-2.5-1.3-0.7-0.7-0.8-0.6-1.2-0.8-0.4-0.50.3-0.6-0.3
Pavlov. Cond. index score0.60.72.9-1.7-0.9-0.8-0.8-0.8-0.7-1.0-0.9-0.5-0.6-0.1-0.5-0.1
Pavlov. Cond. latency score0.60.81.8-1.3-1.0-1.0-0.9-1.0-0.9-1.1-1.0-0.7-0.8-0.4-0.6-0.0
Pavlov. Cond. lever contacts0.50.61.2-1.1-0.6-1.0-0.8-1.0-0.8-1.1-0.9-0.5-0.6-0.2-0.10.6
Pavlov. Cond. magazine entry number0.60.75.42.30.80.60.60.70.50.90.70.30.4-0.40.30.0
Pavlov. Cond. intertrial magazine entries1.51.83.10.41.51.31.41.31.41.11.51.41.31.41.81.1
Pavlov. Cond. lever-magazine prob. diff.0.50.62.8-1.7-0.8-0.8-0.7-0.8-0.7-1.0-0.8-0.5-0.5-0.0-0.4-0.0
Pavlov. Cond. response bias0.50.66.7-2.6-0.6-0.2-0.3-0.2-0.1-0.6-0.30.10.10.80.00.0
Pavlov. Cond. lever latency0.81.11.91.31.30.81.11.11.01.41.11.11.00.70.7-0.1
Pavlov. Cond. magazine entry latency0.20.21.6-1.3-0.20.40.5-0.00.2-0.30.00.00.10.1-0.1-0.4
Pavlov. Cond. change in total contacts1.11.83.9-1.7-1.6-1.2-1.3-1.5-1.3-2.0-1.5-1.4-1.3-0.7-0.80.3
Pavlov. Cond. index score0.50.61.7-1.3-0.9-0.5-0.6-0.9-0.7-1.2-0.8-0.8-0.7-0.4-0.30.2
Pavlov. Cond. latency score0.40.51.7-1.3-0.9-0.4-0.5-0.8-0.6-1.1-0.8-0.7-0.6-0.4-0.40.0
Pavlov. Cond. lever contacts0.81.12.2-1.5-1.5-0.8-1.0-1.0-0.9-1.4-1.1-1.1-1.0-0.7-0.9-0.2
Pavlov. Cond. magazine entry number0.10.21.11.1-0.2-0.5-0.50.0-0.20.3-0.2-0.2-0.3-0.2-0.5-0.3
Pavlov. Cond. intertrial magazine entries0.10.10.30.40.30.10.10.30.30.30.30.30.20.40.50.5
Pavlov. Cond. lever-magazine prob. diff.0.50.61.6-1.3-0.9-0.5-0.6-0.9-0.7-1.2-0.9-0.8-0.7-0.5-0.30.3
Pavlov. Cond. response bias0.60.81.9-1.4-1.2-0.6-0.8-1.0-0.8-1.3-0.9-0.9-0.8-0.6-0.60.1
Time in closed arm before self-admin0.10.10.3-0.60.10.10.00.10.10.20.00.20.10.50.30.3
Time in closed arm after self-admin0.30.30.60.5-0.1-0.5-0.6-0.6-0.7-0.3-0.5-0.6-0.6-0.8-0.30.2
Time in open arm before self-admin0.30.31.40.9-0.00.1-0.00.1-0.20.30.0-0.3-0.1-1.2-0.8-1.2
Time in open arm after self-admin0.30.31.1-1.0-1.1-0.4-0.3-0.3-0.2-0.8-0.5-0.4-0.40.1-0.6-0.4
Bone: periosteal estimation2.14.57.3-0.1-2.7-2.4-2.3-2.0-2.1-2.2-2.1-2.1-2.3-2.1-2.6-1.3
Bone: periosteal perimeter2.54.37.2-0.7-2.7-2.5-2.1-2.1-2.1-2.1-2.2-1.9-2.2-1.8-2.3-1.2
Bone: post-yield work0.71.03.00.3-1.4-0.9-1.0-0.5-0.7-0.3-0.8-0.9-0.9-0.8-1.7-1.6
Progressive ratio test 1 active lever presses0.00.00.20.4-0.1-0.2-0.1-0.0-0.00.1-0.0-0.1-0.10.0-0.1-0.0
Progressive ratio test 1 breakpoint0.00.00.20.4-0.1-0.3-0.2-0.1-0.1-0.0-0.1-0.2-0.2-0.1-0.20.0
Progressive ratio test 1 inactive lever presses0.00.10.3-0.0-0.1-0.2-0.3-0.2-0.2-0.4-0.1-0.1-0.10.10.20.5
Progressive ratio test 2 active lever presses0.91.02.30.01.11.10.91.31.11.51.11.11.10.90.90.0
Progressive ratio test 2 breakpoint0.91.02.2-0.11.11.10.81.31.11.51.11.11.10.90.90.0
Progressive ratio test 2 inactive lever presses0.40.71.10.71.00.90.81.00.91.01.00.90.90.50.70.0
Incentive Sensitization - Responses2.33.25.2-0.51.82.11.72.22.02.31.92.02.01.81.5-0.1
Incentive Sensitization - Breakpoint2.73.55.6-0.61.92.21.82.22.12.42.02.12.11.91.70.0
Sum of active levers in priming session hrs 5-61.31.27.2-2.7-1.50.10.1-0.00.1-0.9-0.1-0.00.10.5-1.2-1.9
Progressive ratio0.30.40.8-0.6-0.9-0.5-0.7-0.5-0.7-0.7-0.7-0.6-0.6-0.5-0.7-0.5
Food seeking constrained by brief footshock0.30.40.6-0.20.80.60.40.70.50.80.50.70.70.70.80.5
Seeking ratio, punishment vs. effort0.30.40.8-0.00.70.60.70.60.80.70.70.70.70.90.60.2
Retroperitoneal fat weight0.83.45.3-1.41.82.01.81.82.01.71.82.02.02.32.10.7
Reaction time number correct2.95.68.70.13.02.52.62.52.62.72.72.62.52.02.60.7
Reaction time mean minus median0.40.91.51.2-0.3-1.0-1.2-1.0-1.1-0.5-1.0-1.1-1.1-1.1-0.40.8
Reaction time mean minus median AUC0.30.71.31.0-0.0-0.8-1.0-0.8-0.9-0.4-0.9-0.9-0.8-0.90.01.1
Reaction time num false alarms1.01.42.5-0.41.31.61.41.31.21.21.31.21.40.91.10.0
Reaction time num false alarms AUC1.42.23.7-0.71.41.91.71.71.61.51.61.61.71.41.3-0.0
Reaction time trials correct on left2.95.68.70.13.02.52.62.52.62.72.72.62.52.02.60.7
Reaction time trials on left2.85.38.70.22.92.42.52.42.52.62.62.52.31.92.60.9
Reaction time mean3.96.29.31.1-1.9-2.9-3.0-2.9-2.9-2.5-2.9-2.9-2.9-2.4-1.61.3
Reaction time mean AUC3.45.48.21.1-1.7-2.7-2.9-2.7-2.7-2.3-2.8-2.7-2.7-2.2-1.41.3
Median of all reaction times4.86.910.10.9-2.1-3.1-3.2-3.1-3.0-2.7-3.1-3.0-3.1-2.4-1.71.3
Reaction time omissions2.13.06.21.9-0.4-2.0-2.1-2.0-1.9-1.3-1.8-1.8-1.8-1.30.02.5
Reaction time false alarm rate0.10.10.5-0.7-0.20.40.20.30.20.00.10.20.30.30.0-0.3
Reaction time premature initiation rate0.91.24.0-2.0-0.60.90.91.01.10.50.80.90.71.2-0.5-1.9
Reaction time premature initiations2.03.65.5-1.71.12.12.12.22.31.92.12.11.92.11.0-1.2
Std. dev. reaction times1.32.43.41.7-0.6-1.7-1.8-1.7-1.7-1.2-1.7-1.7-1.7-1.5-0.41.6
Reaction time trials completed2.85.38.70.22.92.42.52.42.52.62.62.52.31.92.60.9
Reaction time trials AUC2.95.69.70.43.12.42.52.42.52.62.62.52.42.02.81.2
Run reversals in cocaine runway, females0.90.91.7-0.2-1.1-1.1-0.9-1.1-1.0-1.3-1.0-1.0-0.9-0.7-0.80.0
Run reversals in cocaine runway, males1.01.01.60.4-0.5-1.1-1.1-1.3-1.2-1.0-1.2-1.1-1.0-1.2-0.21.0
Latency to leave start box in cocaine runway1.31.52.80.3-0.8-1.5-1.6-1.5-1.3-1.2-1.4-1.2-1.4-0.4-0.11.7
Latency to leave start box in cocaine runway, F0.91.11.80.2-0.9-1.3-1.3-1.2-1.2-1.0-1.3-1.1-1.2-0.5-0.50.8
Latency to leave start box in cocaine runway, M0.40.41.00.5-0.2-0.7-0.8-0.8-0.6-0.5-0.5-0.6-0.7-0.10.11.0
Std. dev. time between licks in bursts0.81.02.20.8-1.0-0.6-0.7-0.8-0.9-0.8-0.9-1.3-1.0-1.5-1.5-1.0
Total sessions with >9 infusions0.50.71.5-0.3-1.0-0.9-0.8-0.9-0.8-1.2-0.8-0.8-0.9-0.5-0.7-0.1
Short access day 1 total inactive lever presses0.20.30.6-0.5-0.7-0.4-0.7-0.5-0.6-0.6-0.5-0.6-0.5-0.8-0.6-0.3
Short access day 10 total inactive lever presses1.53.54.8-0.51.82.22.12.12.12.02.22.22.21.91.5-0.4
Short access day 1 total infusions0.70.91.8-0.7-1.4-0.6-0.8-0.7-0.8-1.1-0.7-0.9-0.8-1.0-1.3-1.1
Short access day 10 total infusions0.60.71.10.8-0.8-1.0-0.9-1.0-0.9-1.0-0.8-0.9-1.0-0.8-0.8-0.0
Short access total infusions0.40.51.00.4-0.9-0.8-0.6-0.7-0.6-1.0-0.6-0.7-0.7-0.7-0.8-0.3
Short access day 1 locomotion0.20.30.9-0.9-0.9-0.2-0.3-0.2-0.1-0.6-0.1-0.2-0.2-0.1-0.7-0.8
Short access day 10 total locomotion1.01.84.2-0.9-2.0-1.1-1.0-1.0-1.1-1.5-1.1-1.3-1.2-1.1-2.0-1.7
Short access total locomotion1.11.33.0-0.9-1.7-1.1-1.0-1.1-1.0-1.6-1.0-1.1-1.1-0.8-1.3-0.8
One hour access (0.3 mA shock)1.21.42.1-1.10.91.41.31.31.40.91.31.41.41.41.0-0.3
Compulsive drug intake0.40.52.5-1.6-1.0-0.2-0.4-0.4-0.4-0.9-0.5-0.4-0.3-0.2-0.8-0.9
One hour access (shock baseline)0.30.50.80.30.80.70.90.70.80.80.90.90.70.60.70.1
Social response proportion0.20.20.4-0.1-0.4-0.6-0.4-0.6-0.4-0.3-0.5-0.4-0.6-0.2-0.5-0.1
Social responses0.20.31.6-0.60.30.10.1-0.10.1-0.3-0.00.30.10.90.91.3
Social time1.41.99.73.1-0.0-1.4-1.1-1.2-1.2-0.6-1.0-1.2-1.4-1.6-0.31.2
Soleus weight0.71.911.7-3.4-1.50.50.60.60.8-0.60.20.50.31.3-1.1-2.4
Bone: stiffness0.40.64.7-0.3-0.90.1-0.20.20.00.1-0.0-0.3-0.3-0.6-1.5-2.2
Tibialis anterior weight1.44.727.2-5.2-0.61.81.61.82.00.21.31.91.73.30.5-1.4
Time to tail flick, vehicle, before self-admin0.91.05.82.40.3-0.8-0.6-0.8-0.8-0.2-0.6-0.9-0.8-1.5-0.20.7
Time to tail flick, vehicle, after self-admin1.62.25.40.62.11.10.71.30.91.41.31.41.41.32.32.1
Time to tail flick, test, before self-admin2.62.73.91.02.01.62.01.61.81.61.91.81.71.51.70.6
Time to tail flick, test, after self-admin1.11.17.02.61.60.30.30.30.20.90.50.30.3-0.41.11.5
Delta time to tail flick, vehicle, before/after SA3.02.96.0-0.81.81.51.21.61.41.21.61.91.82.52.41.7
Delta time to tail flick, test, before/after SA0.50.51.61.30.1-0.6-0.8-0.5-0.8-0.2-0.6-0.7-0.6-1.1-0.20.6
Tibia length0.30.91.60.21.00.90.91.31.10.71.11.21.10.80.6-0.4
Ambulatory time before self-admin0.30.40.80.00.80.40.50.40.50.50.70.70.50.90.90.7
Ambulatory time after self-admin0.70.93.1-1.8-0.11.00.81.00.90.40.80.90.91.00.0-1.1
Bone: tissue strength1.11.12.4-0.21.21.01.00.71.10.81.01.11.11.21.51.2
Total heroin consumption1.01.16.2-2.5-1.40.30.10.30.2-0.6-0.0-0.00.20.5-1.2-2.1
Bone: trabecular number1.42.23.50.4-1.3-1.8-1.7-1.9-1.7-1.6-1.7-1.7-1.7-1.6-1.00.6
Bone: trabecular spacing2.02.65.0-0.41.21.92.21.91.91.61.91.81.91.10.6-1.4
Bone: trabecular thickness1.01.32.7-1.0-1.7-1.1-1.3-1.1-1.0-1.2-1.2-1.2-1.1-0.4-1.2-0.4
Bone: trabecular tissue density3.24.76.5-0.2-2.4-2.3-2.5-2.5-2.3-2.4-2.5-2.5-2.4-1.9-2.2-0.3
Water consumed over 24 hours0.60.82.3-1.20.60.70.70.70.80.40.70.90.81.51.10.8
Number of responses in last shaping day0.30.31.1-1.1-0.8-0.2-0.3-0.2-0.2-0.5-0.3-0.3-0.20.2-0.8-0.8