Hub : Genes

Atp5mc1

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr10_81026083_81026666 0.16 0.1 4.4e-15 0.14 0.12 0.14 0.08 5.6e-15 1.1e-12 6.5e-15 3.6e-09
2 Liver alternative TSS XM_006247188.4 0.13 0.09 5.3e-15 0.12 0.12 0.13 0.11 3.9e-13 2.7e-13 3.8e-14 2.9e-12
3 Liver gene expression Atp5mc1 0.31 0.1 0.0e+00 0.41 0.37 0.41 0.25 1.3e-48 5.6e-43 2.5e-48 2.0e-27
4 Liver alternative TSS NM_017311.1 0.11 0.08 7.1e-13 0.1 0.1 0.11 0.09 3.0e-11 3.4e-11 7.8e-12 6.6e-10
5 NAcc gene expression Atp5mc1 0.03 0.03 7.6e-04 0.03 0.02 0.02 0.02 2.9e-04 1.4e-03 1.7e-03 1.6e-03
6 Liver intron excision ratio chr10_81026083_81026596 0.19 0.1 2.1e-14 0.13 0.1 0.13 0.09 2.7e-14 1.2e-11 2.2e-14 1.8e-10
7 Liver isoform ratio NM_017311.1 0.14 0.12 6.0e-08 0.05 0.03 0.04 0 2.2e-06 1.6e-04 1.9e-05 7.2e-02
8 Liver isoform ratio XM_006247188.4 0.1 0.09 4.6e-08 0.06 0.04 0.05 0.01 8.4e-07 9.1e-05 6.8e-06 5.3e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density1.32.22.81.51.4-1.7-1.4-1.5-1.6-1.51.5
Area under the delay curve0.10.10.2-0.00.1-0.1-0.10.50.00.5-0.5
BMI with tail18.560.069.57.67.1-7.8-7.0-8.3-7.8-8.18.1
BMI without tail1.02.13.01.31.1-1.4-1.0-1.7-1.4-1.71.7
Body weight1.14.65.52.22.1-2.3-2.1-2.0-2.3-2.02.0
Weight adjusted by age0.10.10.3-0.1-0.00.40.00.60.20.5-0.5
Bone surface0.50.91.00.91.0-1.0-1.0-0.9-0.9-0.90.9
Bone volume1.22.02.21.31.4-1.5-1.4-1.4-1.4-1.51.5
Breakpoint value in progressive ratio session3.53.84.4-1.9-1.92.11.91.91.91.9-1.9
Number of licking bursts0.70.91.4-1.0-1.20.91.20.80.90.6-0.6
Context. condit. distance diff. score1.11.31.51.21.2-1.2-1.2-1.0-1.2-1.01.0
Locomotion velocity, session 10.00.00.1-0.2-0.30.10.3-0.00.0-0.10.1
Locomotion distance, session 14.86.26.6-2.6-2.52.42.52.42.42.5-2.5
Locomotion velocity, session 21.31.51.9-1.3-1.01.31.01.21.31.4-1.4
Locomotion distance, session 26.59.110.1-3.1-3.23.13.13.02.92.8-2.8
Locomotion velocity, session 30.30.30.80.60.9-0.5-0.9-0.4-0.5-0.10.1
Locomotion distance, session 31.81.92.9-1.2-1.11.21.11.61.31.7-1.7
Stereotopy head waving bouts, day 34.35.15.72.02.2-2.1-2.2-2.3-2.3-2.42.4
Stereotopy head waving duration, day 33.34.04.31.92.1-1.9-2.0-2.1-2.1-2.02.0
Locomotion velocity, session 71.01.11.3-1.1-1.00.91.01.21.11.0-1.0
Locomotion distance, session 75.77.27.9-2.8-2.82.52.72.72.62.7-2.7
Stereotopy head waving bouts, day 70.30.40.60.50.6-0.5-0.6-0.6-0.6-0.80.8
Stereotopy head waving duration, day 70.20.20.30.40.5-0.3-0.5-0.4-0.4-0.50.5
Locomotion velocity, session 80.50.60.80.80.8-0.6-0.8-0.6-0.7-0.90.9
Locomotion distance, session 80.60.91.3-0.8-0.90.80.91.10.81.1-1.1
Degree of sensitization distance0.10.10.1-0.3-0.40.10.30.10.2-0.10.1
Degree of sensitization stereotypy0.20.30.4-0.6-0.60.70.60.50.60.2-0.2
Conditioned locomotion1.92.32.91.71.5-1.4-1.5-1.5-1.5-1.41.4
Cocaine response after cond. corrected6.06.87.92.52.4-2.6-2.4-2.8-2.6-2.72.7
Cocaine response after cond. not corrected3.43.74.62.01.8-2.0-1.8-2.1-1.9-1.91.9
Cocaine response before conditioning2.93.64.2-1.8-1.81.81.81.91.92.0-2.0
Saline control response0.10.10.50.4-0.0-0.5-0.0-0.7-0.3-0.30.3
Bone: connectivity density0.30.50.80.70.8-0.9-0.7-0.5-0.8-0.40.4
Bone: cortical apparent density5.06.67.8-2.8-2.52.62.42.72.72.4-2.4
Bone: cortical area0.40.61.00.90.8-0.9-0.8-1.0-0.7-0.60.6
Bone: cortical porosity0.40.40.60.60.6-0.7-0.6-0.8-0.6-0.50.5
Bone: cortical porosity0.20.30.50.40.5-0.6-0.5-0.7-0.5-0.40.4
Bone: cortical thickness0.20.20.40.60.6-0.5-0.6-0.6-0.3-0.30.3
Bone: cortical thickness0.70.81.8-0.6-0.50.70.51.10.71.4-1.4
Bone: cortical tissue density5.57.38.7-2.9-2.62.82.62.92.92.5-2.5
Condit. Reinf. active minus inactive responses0.91.01.4-1.1-1.21.21.10.71.10.7-0.7
Condit. Reinf. active-inactive response ratio0.00.00.30.20.00.0-0.0-0.5-0.0-0.10.1
Condit. Reinf. active responses1.11.31.9-1.4-1.31.31.30.91.20.8-0.8
Condit. Reinf. inactive responses1.11.42.0-1.4-1.21.11.21.41.10.9-0.9
Incentive salience index mean1.92.22.8-1.6-1.71.61.71.31.61.2-1.2
Condit. Reinf. lever presses2.63.44.3-1.9-2.11.92.11.81.91.6-1.6
Condit. Reinf. active minus inactive responses0.10.10.3-0.5-0.50.10.50.20.20.1-0.1
Condit. Reinf. active-inactive response ratio0.10.10.5-0.4-0.70.20.70.10.2-0.10.1
Condit. Reinf. active responses0.10.10.2-0.4-0.3-0.00.40.30.20.4-0.4
Condit. Reinf. inactive responses0.00.10.10.10.2-0.2-0.20.10.10.4-0.4
Condit. Reinf. lever presses0.70.92.1-0.6-0.50.70.51.00.81.5-1.5
Condit. Reinf. lever reinforcers received0.10.20.3-0.4-0.4-0.00.40.40.30.5-0.5
Conditioned reinforcement - actives0.10.10.3-0.5-0.6-0.10.6-0.00.2-0.10.1
Conditioned reinforcement - inactives0.10.10.20.0-0.2-0.30.2-0.10.00.4-0.4
Conditioned locomotion0.20.20.40.20.1-0.6-0.1-0.6-0.4-0.60.6
Patch foraging indifference point 0 sec1.11.82.81.71.6-1.3-1.6-0.9-1.4-1.01.0
Patch foraging indifference point AUC0.10.10.3-0.0-0.10.20.10.40.20.5-0.5
Delay disc. indifference point, 0s delay0.10.10.30.30.3-0.2-0.30.3-0.10.5-0.5
Delay disc. indifference point, 16s delay0.90.91.41.01.2-1.1-1.2-0.8-1.0-0.50.5
Delay disc. indifference point, 2s delay0.10.10.3-0.0-0.00.10.00.50.10.3-0.3
Delay disc. indifference point, 24s delay0.70.70.8-0.9-0.80.80.80.90.80.8-0.8
Delay disc. indifference point, 4s delay1.31.42.6-0.9-0.70.90.61.61.01.6-1.6
Delay disc. indifference point, 8s delay0.10.10.4-0.3-0.20.10.20.60.20.5-0.5
Indifference point function ln k0.00.00.1-0.3-0.20.20.20.20.20.1-0.1
Indifference point function log k0.00.00.1-0.3-0.20.20.20.20.20.1-0.1
Patch foraging total patch changes 0 sec1.42.23.21.81.7-1.4-1.7-1.1-1.5-1.21.2
Patch foraging total patch changes 12 sec0.10.10.20.50.3-0.4-0.3-0.0-0.4-0.10.1
Patch foraging total patch changes 18 sec2.22.83.82.01.9-1.8-1.9-1.5-1.8-1.11.1
Patch foraging total patch changes 24 sec1.01.21.91.41.2-1.1-1.2-0.9-1.2-0.90.9
Patch foraging total patch changes 6 sec0.91.42.41.51.4-1.2-1.4-0.9-1.3-0.80.8
Patch foraging time to switch 0 sec0.00.10.1-0.3-0.30.20.30.40.20.2-0.2
Patch foraging water rate 0 sec1.72.73.11.71.8-1.6-1.7-1.7-1.7-1.41.4
Patch foraging water rate 12 sec0.40.61.00.91.0-0.9-1.0-0.8-0.8-0.40.4
Patch foraging water rate 18 sec0.00.00.10.1-0.00.2-0.0-0.30.00.2-0.2
Patch foraging water rate 24 sec1.42.02.51.51.4-1.2-1.4-1.6-1.5-1.31.3
Patch foraging water rate 6 sec0.00.00.10.20.2-0.3-0.10.1-0.30.1-0.1
Seeking ratio, delayed vs. immediate footshock1.92.22.61.41.6-1.6-1.6-1.6-1.4-1.41.4
Distance traveled before self-admin2.12.23.1-1.4-1.71.31.81.51.31.4-1.4
Distance traveled after self-admin0.10.10.30.50.3-0.5-0.3-0.0-0.4-0.30.3
Extensor digitorum longus weight0.93.44.31.82.1-1.9-2.1-1.8-1.7-1.71.7
Bone: elastic displacement0.00.00.10.20.1-0.1-0.10.1-0.2-0.10.1
Bone: elastic work0.00.00.00.20.1-0.1-0.10.0-0.10.2-0.2
Bone: endosteal estimation0.00.10.20.30.2-0.5-0.2-0.3-0.3-0.10.1
Bone: endosteal perimeter0.20.40.50.70.5-0.7-0.5-0.7-0.6-0.60.6
Epididymis fat weight0.10.30.80.50.4-0.9-0.4-0.7-0.6-0.50.5
Delta time in closed arm before/after self-admin0.20.20.30.30.4-0.2-0.5-0.4-0.2-0.60.6
Delta time in open arm before/after self-admin0.00.00.00.10.00.0-0.00.10.00.2-0.2
Diff in mean of infusions in LGA sessions1.41.52.3-1.3-1.51.31.50.91.20.9-0.9
Delay discount exponential model param0.10.10.40.20.1-0.0-0.0-0.6-0.2-0.60.6
Extinction: sum of active levers before priming0.80.81.2-0.8-0.80.80.81.00.91.1-1.1
Active lever presses in extinction session 60.00.00.00.10.1-0.1-0.1-0.0-0.10.1-0.1
Bone: final force0.20.20.60.50.3-0.7-0.3-0.8-0.5-0.30.3
Bone: final moment0.20.40.70.60.5-0.8-0.5-0.8-0.6-0.40.4
Food consumed during 24 hour testing period1.92.32.9-1.6-1.51.71.51.71.61.3-1.3
Glucose1.01.61.91.21.3-1.0-1.4-1.2-1.2-1.41.4
Heart weight1.72.53.21.41.3-1.6-1.4-1.7-1.6-1.81.8
Delay discount hyperbolic model param0.20.20.50.20.1-0.1-0.1-0.7-0.2-0.70.7
Intermittent access intake day 1-15 change1.01.01.41.11.0-1.0-1.0-0.7-1.2-1.01.0
Intermittent access intake escalation0.50.50.70.80.7-0.7-0.7-0.3-0.9-0.60.6
Intermittent access intake escalation 20.70.61.01.00.8-0.8-0.8-0.5-1.0-0.70.7
Intermitt. access day 1 inactive lever presses0.00.00.1-0.0-0.1-0.30.2-0.1-0.1-0.10.1
Intermitt. access day 15 inactive lever presses1.61.72.21.41.5-1.5-1.5-1.4-1.3-0.80.8
Intermitt. access escalation Index0.10.10.3-0.4-0.30.50.40.40.3-0.10.1
Intermittent access day 1 total infusions0.70.81.4-1.2-1.10.91.00.31.10.6-0.6
Intermittent access day 15 total infusions0.30.30.5-0.6-0.70.50.70.40.50.4-0.4
Intermittent access terminal intake (last 3 days)0.10.10.1-0.3-0.40.10.40.00.20.2-0.2
Intermittent access total infusions0.10.10.2-0.4-0.40.10.4-0.00.30.4-0.4
Intermittent access day 1 locomotion1.92.03.2-1.8-1.61.51.61.11.61.0-1.0
Intermittent access day 15 total locomotion0.20.20.5-0.6-0.70.50.70.30.50.1-0.1
Intermittent access total locomotion0.40.50.8-0.9-0.90.60.90.30.70.4-0.4
Intermittent access standard deviation0.90.91.41.11.0-1.0-1.0-0.9-1.2-0.60.6
Left kidney weight0.00.00.10.10.2-0.2-0.3-0.0-0.1-0.00.0
Right kidney weight0.51.52.21.21.5-1.1-1.5-1.0-1.2-1.11.1
Cocaine induced anxiety0.00.10.10.1-0.1-0.40.1-0.2-0.2-0.30.3
Post-drug Anxiety0.70.81.5-0.9-1.20.81.20.70.80.7-0.7
Baseline Anxiety0.00.00.10.20.10.3-0.1-0.2-0.10.0-0.0
Tail length16.951.358.5-7.1-6.77.26.67.77.27.4-7.4
Length with tail7.929.137.0-5.3-4.75.34.66.15.45.8-5.8
Length without tail0.00.10.30.20.5-0.4-0.50.2-0.20.1-0.1
Times rat made contact with spout0.60.71.1-1.0-1.01.00.90.61.00.4-0.4
Lifetime Intake0.30.30.4-0.6-0.60.50.60.30.50.6-0.6
Liver weight, left0.91.41.5-1.2-1.21.21.21.21.21.2-1.2
Liver weight, right0.40.61.1-0.7-0.50.60.40.80.71.1-1.1
Locomotor activity0.10.20.30.50.2-0.6-0.2-0.4-0.5-0.50.5
Locomotor testing distance0.40.61.01.00.5-1.0-0.4-0.5-1.0-0.90.9
Locomotor testing rearing0.10.10.30.50.2-0.6-0.10.1-0.4-0.20.2
Locomotion in novel chamber0.00.10.1-0.1-0.30.00.40.30.1-0.20.2
Locomotion in novel chamber post-restriction1.92.33.01.71.3-1.5-1.3-1.7-1.6-1.51.5
Fecal boli incidents, locomotor time 12.93.13.81.81.7-1.5-1.7-1.8-1.8-2.02.0
Change in fecal boli incidents, locomotor task1.61.52.0-1.4-1.21.11.21.21.31.1-1.1
Time >=10cm from walls, locomotor time 10.00.00.1-0.0-0.3-0.00.3-0.10.20.0-0.0
Bouts of movement, locomotor time 10.20.20.50.30.7-0.7-0.7-0.3-0.5-0.30.3
Total resting periods, locomotor time 10.60.60.90.60.9-1.0-0.9-0.7-0.8-0.70.7
Rest time, locomotor task time 10.10.10.20.30.4-0.2-0.4-0.1-0.3-0.40.4
Distance moved, locomotor task time 12.12.33.3-1.5-1.81.61.81.21.61.3-1.3
Vertical activity count, locomotor time 10.40.40.8-0.6-0.90.70.90.30.70.6-0.6
Time >=10cm from walls, locomotor time 20.30.30.4-0.5-0.60.60.60.40.60.4-0.4
Bouts of movement, locomotor time 20.10.10.20.40.2-0.3-0.2-0.2-0.4-0.30.3
Total resting periods, locomotor time 20.10.10.20.50.2-0.4-0.2-0.3-0.4-0.40.4
Rest time, locomotor task time 20.50.60.9-0.8-0.80.90.70.80.80.5-0.5
Distance moved, locomotor task time 20.20.20.4-0.4-0.30.40.20.60.40.6-0.6
Vertical activity count, locomotor time 20.00.00.1-0.1-0.10.10.10.20.10.3-0.3
Light reinforcement 10.00.00.00.2-0.0-0.20.10.2-0.2-0.10.1
Light reinforcement 20.40.60.8-0.7-0.90.80.90.80.70.6-0.6
Bone: marrow area0.00.00.10.20.1-0.4-0.1-0.2-0.20.0-0.0
Bone: maximum diameter0.30.60.80.80.6-0.8-0.6-0.9-0.7-0.70.7
Bone: maximum force0.71.21.81.11.1-1.3-1.1-1.3-1.1-0.80.8
Bone: maximum moment0.81.31.91.21.2-1.4-1.2-1.3-1.2-0.80.8
Mean time between licks in bursts0.91.22.01.11.1-1.3-1.2-1.4-1.0-0.80.8
Mean num. licks in bursts0.00.10.10.20.4-0.1-0.4-0.2-0.1-0.10.1
Cd content in liver0.10.10.5-0.2-0.60.30.70.00.30.0-0.0
Co content in liver0.00.00.10.0-0.1-0.10.1-0.3-0.2-0.30.3
Cu content in liver8.310.113.1-3.6-3.63.43.62.93.32.3-2.3
Fe content in liver1.62.02.6-1.6-1.51.31.51.21.41.4-1.4
K content in liver0.30.30.7-0.8-0.70.70.60.40.60.2-0.2
Mg content in liver1.91.92.5-1.6-1.61.41.51.31.41.1-1.1
Mn content in liver4.34.95.9-2.0-2.12.22.12.32.12.4-2.4
Na content in liver0.30.30.5-0.7-0.70.70.60.60.50.3-0.3
Rb content in liver0.20.31.0-1.0-0.60.30.70.30.40.0-0.0
Se content in liver0.20.30.40.60.4-0.4-0.4-0.6-0.6-0.50.5
Sr content in liver0.90.81.8-0.4-0.50.90.50.90.91.3-1.3
Zn content in liver0.00.00.1-0.2-0.30.00.30.0-0.0-0.20.2
Bone: minimum diameter0.00.10.20.00.2-0.3-0.2-0.5-0.0-0.00.0
Time in familiar zone, hab. session 10.10.10.3-0.1-0.40.10.40.30.20.5-0.5
Time in novel zone, hab. session 12.32.23.11.31.6-1.2-1.6-1.3-1.4-1.71.7
Total zone transitions, hab. session 16.79.410.1-3.1-3.23.03.22.93.13.0-3.0
Total locomotion distance, hab. session 13.85.46.3-2.3-2.52.22.52.32.32.2-2.2
Locomotion velocity, hab. session 14.86.77.9-2.6-2.82.52.82.42.62.5-2.5
Time in familiar zone, hab. session 21.11.21.31.11.0-1.1-1.0-1.2-1.1-1.11.1
Time in novel zone, hab. session 20.10.10.2-0.3-0.30.30.30.40.30.4-0.4
Total zone transitions, hab. session 24.65.97.1-2.5-2.72.42.72.22.42.3-2.3
Total locomotion distance, hab. session 20.91.21.8-1.2-1.31.11.31.01.10.8-0.8
Locomotion velocity, hab. session 21.11.52.1-1.3-1.41.31.41.11.21.0-1.0
Novel to familiar place preference ratio0.20.20.3-0.3-0.40.30.40.40.50.5-0.5
Novelty place preference0.20.20.3-0.2-0.30.30.30.40.40.6-0.6
Time in novel zone, NPP test0.10.10.1-0.1-0.10.10.20.20.20.4-0.4
Total zone transitions, NPP test6.49.19.9-2.9-3.22.93.13.12.93.0-3.0
Total locomotion distance, NPP test1.92.63.2-1.5-1.81.51.81.71.51.5-1.5
Locomotion velocity, NPP test2.53.53.9-1.7-2.01.81.91.91.82.0-2.0
Intraocular pressure1.31.82.3-1.5-1.21.01.21.41.31.5-1.5
Delta distance traveled before/after self-admin2.62.83.51.71.9-1.8-1.9-1.5-1.7-1.51.5
Delta ambulatory time before/after self-admin3.03.33.71.71.8-1.7-1.8-1.8-1.7-1.91.9
Parametrial fat weight0.10.20.3-0.5-0.60.40.60.30.40.4-0.4
Pavlov. Cond. lever latency1.51.92.61.31.6-1.3-1.6-1.3-1.4-1.31.3
Pavlov. Cond. magazine entry latency0.20.30.5-0.5-0.60.40.70.40.50.5-0.5
Pavlov. Cond. change in total contacts3.84.05.0-2.0-2.22.02.21.92.01.8-1.8
Pavlov. Cond. index score1.01.31.9-1.1-1.31.01.41.01.11.0-1.0
Pavlov. Cond. latency score1.01.31.9-1.1-1.31.01.41.11.21.0-1.0
Pavlov. Cond. lever contacts2.73.13.8-1.7-1.91.72.01.81.71.7-1.7
Pavlov. Cond. magazine entry number0.50.71.10.81.0-0.7-1.0-0.7-0.8-0.70.7
Pavlov. Cond. intertrial magazine entries0.70.91.5-1.2-1.11.01.10.70.90.7-0.7
Pavlov. Cond. lever-magazine prob. diff.0.91.11.6-1.0-1.20.91.30.91.11.0-1.0
Pavlov. Cond. response bias0.81.01.4-0.9-1.10.91.21.00.91.0-1.0
Pavlov. Cond. lever latency1.41.82.9-1.5-1.71.31.71.01.50.8-0.8
Pavlov. Cond. magazine entry latency0.60.61.2-0.8-0.51.10.50.90.80.8-0.8
Pavlov. Cond. change in total contacts0.30.40.90.80.9-0.6-0.9-0.2-0.70.0-0.0
Pavlov. Cond. index score0.20.30.70.60.8-0.4-0.8-0.4-0.6-0.20.2
Pavlov. Cond. latency score0.10.10.40.30.6-0.1-0.6-0.1-0.30.0-0.0
Pavlov. Cond. lever contacts0.91.21.91.31.4-1.0-1.4-0.9-1.2-0.60.6
Pavlov. Cond. magazine entry number0.00.10.2-0.0-0.4-0.10.4-0.10.0-0.20.2
Pavlov. Cond. intertrial magazine entries1.41.82.3-1.3-1.51.11.51.21.31.3-1.3
Pavlov. Cond. lever-magazine prob. diff.0.30.40.90.70.9-0.5-1.0-0.4-0.7-0.30.3
Pavlov. Cond. response bias0.60.81.41.01.2-0.9-1.2-0.7-1.0-0.50.5
Time in closed arm before self-admin3.03.44.21.82.0-2.1-2.0-1.9-1.9-1.51.5
Time in closed arm after self-admin3.83.84.41.82.1-1.9-2.1-2.0-1.8-2.02.0
Time in open arm before self-admin0.40.40.6-0.7-0.80.60.80.70.70.4-0.4
Time in open arm after self-admin0.40.40.4-0.5-0.70.60.70.70.60.7-0.7
Bone: periosteal estimation0.30.71.10.80.8-1.1-0.8-1.0-0.8-0.60.6
Bone: periosteal perimeter1.01.62.01.41.2-1.4-1.3-1.4-1.2-1.11.1
Bone: post-yield work0.70.91.20.91.1-1.1-1.1-1.0-0.9-0.70.7
Progressive ratio test 1 active lever presses0.90.91.3-1.1-1.10.91.10.91.00.7-0.7
Progressive ratio test 1 breakpoint1.01.01.4-1.1-1.21.01.11.01.10.8-0.8
Progressive ratio test 1 inactive lever presses0.20.20.50.50.3-0.5-0.3-0.7-0.4-0.40.4
Progressive ratio test 2 active lever presses0.70.81.4-1.0-1.20.51.20.60.90.7-0.7
Progressive ratio test 2 breakpoint0.30.30.8-0.7-0.90.10.90.30.60.4-0.4
Progressive ratio test 2 inactive lever presses0.00.10.20.1-0.1-0.50.1-0.4-0.10.1-0.1
Incentive Sensitization - Responses0.10.10.4-0.0-0.3-0.60.3-0.3-0.1-0.20.2
Incentive Sensitization - Breakpoint0.20.20.70.2-0.1-0.80.1-0.4-0.3-0.40.4
Sum of active levers in priming session hrs 5-65.95.76.0-2.4-2.32.42.32.42.42.4-2.4
Progressive ratio0.10.20.20.50.2-0.4-0.2-0.3-0.5-0.50.5
Food seeking constrained by brief footshock0.00.00.1-0.1-0.0-0.20.1-0.10.0-0.20.2
Seeking ratio, punishment vs. effort0.60.71.0-1.0-0.80.90.80.71.00.8-0.8
Retroperitoneal fat weight0.20.71.11.00.8-1.0-0.8-0.7-1.0-0.50.5
Reaction time number correct1.11.52.61.41.5-1.6-1.5-1.1-1.2-0.60.6
Reaction time mean minus median2.22.93.6-1.8-1.51.91.51.51.81.8-1.8
Reaction time mean minus median AUC3.03.94.6-2.1-1.92.11.91.62.12.0-2.0
Reaction time num false alarms1.01.31.7-1.3-1.21.21.31.01.20.9-0.9
Reaction time num false alarms AUC1.01.41.6-1.3-1.31.31.31.11.21.1-1.1
Reaction time trials correct on left1.11.52.61.41.5-1.6-1.5-1.1-1.2-0.60.6
Reaction time trials on left1.01.42.41.31.4-1.6-1.4-1.0-1.1-0.60.6
Reaction time mean1.11.52.4-1.6-1.21.41.20.81.41.0-1.0
Reaction time mean AUC1.31.82.8-1.7-1.31.61.30.91.51.1-1.1
Median of all reaction times0.40.51.1-1.1-0.70.80.70.30.80.6-0.6
Reaction time omissions1.21.71.8-1.4-1.31.31.31.11.31.3-1.3
Reaction time false alarm rate1.72.33.2-1.7-1.71.81.71.51.51.1-1.1
Reaction time premature initiation rate0.40.61.0-0.6-0.60.90.60.70.61.0-1.0
Reaction time premature initiations0.10.20.70.10.10.1-0.10.30.10.8-0.8
Std. dev. reaction times2.12.93.7-1.9-1.61.91.51.41.81.7-1.7
Reaction time trials completed1.01.42.41.31.4-1.6-1.4-1.0-1.1-0.60.6
Reaction time trials AUC1.01.52.51.41.4-1.6-1.5-1.0-1.2-0.60.6
Run reversals in cocaine runway, females0.30.30.5-0.5-0.20.40.20.60.50.7-0.7
Run reversals in cocaine runway, males1.81.72.21.41.0-1.4-1.0-1.4-1.4-1.51.5
Latency to leave start box in cocaine runway6.26.77.52.62.7-2.4-2.7-2.4-2.5-2.62.6
Latency to leave start box in cocaine runway, F9.09.811.53.23.4-3.0-3.4-2.9-3.1-3.03.0
Latency to leave start box in cocaine runway, M0.20.20.50.40.2-0.3-0.2-0.5-0.4-0.70.7
Std. dev. time between licks in bursts0.50.60.90.90.9-0.9-0.9-0.8-0.9-0.50.5
Total sessions with >9 infusions1.01.11.7-1.1-1.01.11.01.31.00.8-0.8
Short access day 1 total inactive lever presses0.60.72.1-0.4-0.40.10.40.80.51.4-1.4
Short access day 10 total inactive lever presses0.40.50.90.80.6-1.0-0.6-0.9-0.7-0.20.2
Short access day 1 total infusions0.20.20.5-0.3-0.20.40.20.70.40.7-0.7
Short access day 10 total infusions0.00.00.2-0.4-0.20.20.1-0.20.20.0-0.0
Short access total infusions0.00.00.0-0.2-0.00.2-0.00.20.10.1-0.1
Short access day 1 locomotion0.00.00.0-0.2-0.10.10.10.20.1-0.20.2
Short access day 10 total locomotion0.91.01.9-1.4-1.11.11.10.81.10.5-0.5
Short access total locomotion0.20.20.6-0.8-0.50.50.40.30.5-0.20.2
One hour access (0.3 mA shock)0.60.71.1-0.9-1.00.61.10.50.80.8-0.8
Compulsive drug intake7.17.27.4-2.7-2.72.62.72.72.72.6-2.6
One hour access (shock baseline)1.41.72.31.31.0-1.3-1.0-1.5-1.3-1.31.3
Social response proportion2.52.73.2-1.6-1.61.81.71.61.71.6-1.6
Social responses0.10.10.3-0.0-0.30.20.30.50.20.5-0.5
Social time0.00.00.10.2-0.3-0.20.3-0.3-0.1-0.10.1
Soleus weight1.64.65.02.02.2-2.2-2.2-2.2-2.1-2.12.1
Bone: stiffness0.10.10.40.40.3-0.5-0.3-0.6-0.4-0.10.1
Tibialis anterior weight0.10.30.4-0.5-0.50.50.60.60.70.6-0.6
Time to tail flick, vehicle, before self-admin1.41.51.9-1.3-1.31.31.40.91.31.1-1.1
Time to tail flick, vehicle, after self-admin0.70.81.21.11.1-0.9-1.1-0.7-0.9-0.50.5
Time to tail flick, test, before self-admin0.40.40.60.60.8-0.6-0.7-0.6-0.6-0.70.7
Time to tail flick, test, after self-admin0.40.40.70.60.8-0.6-0.8-0.4-0.6-0.50.5
Delta time to tail flick, vehicle, before/after SA3.03.03.92.02.0-1.8-2.0-1.4-1.8-1.41.4
Delta time to tail flick, test, before/after SA0.50.40.6-0.5-0.50.60.50.80.60.8-0.8
Tibia length0.71.82.31.21.4-1.5-1.4-1.3-1.3-1.31.3
Ambulatory time before self-admin1.21.21.7-0.9-1.30.91.31.20.91.1-1.1
Ambulatory time after self-admin0.40.50.80.80.7-0.9-0.6-0.5-0.8-0.50.5
Bone: tissue strength1.00.91.41.01.0-1.2-1.1-1.0-1.0-0.60.6
Total heroin consumption0.70.81.1-0.8-0.90.80.90.70.91.0-1.0
Bone: trabecular number0.20.20.40.30.4-0.6-0.3-0.4-0.6-0.60.6
Bone: trabecular spacing0.00.00.10.1-0.20.00.2-0.30.0-0.10.1
Bone: trabecular thickness3.23.95.52.12.3-2.1-2.3-1.7-2.0-1.51.5
Bone: trabecular tissue density0.00.00.1-0.1-0.10.20.00.30.20.3-0.3
Water consumed over 24 hours0.10.10.2-0.2-0.20.40.10.30.30.1-0.1
Number of responses in last shaping day2.32.42.71.51.6-1.6-1.5-1.6-1.5-1.61.6