Hub : Genes

Atp1b3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain gene expression Atp1b3 0.09 0.05 9.8e-05 0.03 0.02 0.02 0.04 9.4e-04 3.4e-03 3.0e-03 1.7e-04
2 BLA mRNA stability Atp1b3 0.07 0.04 9.0e-04 0.08 0.05 0.06 0.07 7.3e-05 7.4e-04 4.6e-04 2.0e-04
3 PL mRNA stability Atp1b3 0.13 0.06 5.6e-17 0.18 0.16 0.17 0.17 1.3e-19 5.3e-17 6.6e-18 2.8e-18
4 Brain mRNA stability Atp1b3 0.46 0.11 0.0e+00 0.41 0.41 0.43 0.43 3.5e-41 5.8e-41 4.9e-43 4.6e-43
5 IL mRNA stability Atp1b3 0.23 0.12 3.0e-03 0.05 0.06 0.05 0.04 2.7e-02 1.5e-02 2.5e-02 3.1e-02
6 NAcc mRNA stability Atp1b3 0.11 0.05 1.2e-13 0.13 0.12 0.12 0.14 3.0e-15 3.4e-14 4.4e-14 2.0e-15
7 Liver mRNA stability Atp1b3 0.06 0.03 3.6e-05 0.04 0.03 0.03 0.04 7.4e-05 1.6e-04 1.0e-04 5.0e-05
8 OFC mRNA stability Atp1b3 0.41 0.13 2.0e-07 0.26 0.26 0.25 0.27 8.8e-07 6.7e-07 1.1e-06 4.5e-07
9 Brain intron excision ratio chr8_96922523_96923793 0.04 0.03 2.1e-04 0.04 0.04 0.03 0.03 2.7e-04 3.3e-04 2.0e-03 1.0e-03
10 Brain intron excision ratio chr8_96922523_96941339 0.06 0.03 2.8e-05 0.05 0.05 0.06 0.05 1.1e-05 2.2e-05 7.6e-06 4.3e-05
11 BLA gene expression Atp1b3 0.13 0.07 9.3e-05 0.09 0.07 0.09 0.09 2.2e-05 1.8e-04 1.6e-05 2.0e-05
12 Liver gene expression Atp1b3 0.28 0.09 0.0e+00 0.19 0.19 0.2 0.2 8.0e-21 7.6e-21 1.4e-21 2.2e-21
13 Adipose gene expression Atp1b3 0.11 0.05 7.1e-11 0.09 0.08 0.08 0.08 3.2e-10 1.3e-09 3.1e-09 3.2e-09
14 PL gene expression Atp1b3 0.15 0.06 0.0e+00 0.18 0.19 0.18 0.19 2.0e-19 4.0e-20 5.8e-20 4.7e-20
15 pVTA mRNA stability Atp1b3 0.14 0.08 2.7e-04 0.1 0.08 0.08 0.09 6.1e-05 2.5e-04 1.7e-04 1.1e-04
16 IL gene expression Atp1b3 0.16 0.09 6.5e-03 0.08 0.04 0.03 0.03 5.8e-03 3.7e-02 6.0e-02 5.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bone: apparent density0.40.61.2-0.81.11.1-1.0-0.9-1.1-0.7-0.80.9-1.00.1-0.2-0.30.20.80.1
Area under the delay curve0.40.41.9-0.20.70.7-0.7-0.6-0.70.0-0.40.6-0.3-0.7-0.6-0.40.41.4-0.9
BMI with tail5.216.730.95.0-5.6-5.65.35.05.34.04.6-4.64.11.11.52.1-2.2-2.91.2
BMI without tail3.06.217.84.2-3.3-3.33.12.73.04.02.0-1.82.5-1.0-0.7-0.10.3-1.3-1.0
Body weight4.418.437.56.1-5.5-5.55.55.05.45.34.4-4.24.7-0.20.30.8-0.7-4.70.4
Weight adjusted by age2.52.85.32.2-2.1-2.12.11.92.01.71.7-1.52.3-0.00.40.3-0.2-2.30.1
Bone surface0.81.43.0-0.91.71.7-1.5-1.3-1.7-0.5-1.11.2-1.2-0.8-0.9-1.01.00.3-0.7
Bone volume0.40.71.6-0.71.31.3-1.1-1.0-1.2-0.5-0.80.9-0.8-0.4-0.5-0.60.60.4-0.4
Breakpoint value in progressive ratio session1.11.23.6-1.71.11.1-1.4-1.0-1.5-1.6-0.90.8-1.90.0-0.20.10.01.3-0.4
Number of licking bursts0.70.82.50.50.60.6-0.5-0.5-0.60.9-0.50.5-0.5-1.6-1.5-1.31.20.2-1.4
Context. condit. distance diff. score1.11.33.6-1.6-0.2-0.2-0.10.3-0.0-1.90.7-0.90.21.61.61.8-1.6-0.11.5
Locomotion velocity, session 11.51.63.20.9-1.6-1.61.61.81.40.51.5-1.50.61.01.11.3-1.3-0.40.8
Locomotion distance, session 13.44.47.11.4-2.7-2.72.52.62.30.62.5-2.61.51.82.01.9-2.2-1.21.8
Locomotion velocity, session 24.55.310.91.7-2.7-2.72.83.32.60.82.7-2.81.91.82.02.3-2.4-1.31.5
Locomotion distance, session 24.86.812.52.6-3.3-3.33.33.53.01.73.1-3.12.41.51.71.9-2.2-1.71.5
Locomotion velocity, session 30.80.93.11.6-0.5-0.50.80.80.41.81.1-1.11.2-1.0-1.0-0.7-0.10.3-1.0
Locomotion distance, session 30.10.10.70.2-0.2-0.20.10.5-0.10.20.6-0.40.7-0.2-0.10.1-0.1-0.8-0.0
Stereotopy head waving bouts, day 33.44.112.82.80.20.20.40.10.13.6-0.10.20.6-3.3-3.1-2.82.3-0.6-3.1
Stereotopy head waving duration, day 32.73.212.73.1-0.6-0.61.00.60.73.60.3-0.30.6-2.6-2.5-2.11.6-0.3-2.5
Locomotion velocity, session 73.13.45.11.3-2.2-2.22.31.82.20.72.1-2.12.11.71.71.9-2.1-0.11.6
Locomotion distance, session 70.50.71.30.1-0.9-0.90.80.80.8-0.30.6-0.40.61.11.11.1-0.8-0.81.1
Stereotopy head waving bouts, day 71.11.23.9-0.61.41.4-1.2-1.1-1.4-0.1-0.70.4-0.9-1.0-1.1-0.80.32.0-1.4
Stereotopy head waving duration, day 71.72.16.1-0.31.61.6-1.3-1.5-1.60.4-1.00.6-1.0-1.6-1.8-1.50.82.5-1.9
Locomotion velocity, session 82.32.76.30.4-1.6-1.61.61.71.4-0.21.9-2.10.92.01.92.1-2.50.71.7
Locomotion distance, session 82.23.25.80.0-1.8-1.81.51.81.5-0.72.2-2.31.62.12.12.3-2.4-0.61.9
Degree of sensitization distance0.50.51.7-0.3-0.6-0.60.40.10.7-0.7-0.00.0-0.31.31.31.0-0.80.21.3
Degree of sensitization stereotypy0.80.93.0-1.40.80.8-0.7-0.4-0.8-1.40.2-0.5-0.60.80.70.9-1.31.70.3
Conditioned locomotion1.21.43.4-1.70.70.7-1.0-0.9-0.8-1.9-1.00.9-1.51.31.00.8-0.61.81.0
Cocaine response after cond. corrected0.60.62.41.4-0.2-0.20.50.10.31.50.0-0.00.4-1.0-1.1-1.00.70.8-1.1
Cocaine response after cond. not corrected0.91.03.61.7-0.3-0.30.60.20.41.9-0.10.10.2-1.3-1.3-1.21.00.8-1.5
Cocaine response before conditioning0.30.31.00.7-0.2-0.20.10.20.10.9-0.20.2-0.1-0.9-0.8-0.70.8-0.2-1.0
Saline control response1.72.23.71.4-1.9-1.91.81.71.91.01.6-1.61.70.80.91.0-1.0-1.51.0
Bone: connectivity density0.81.32.5-1.61.51.5-1.4-1.3-1.5-1.5-1.11.1-1.20.20.0-0.20.11.00.1
Bone: cortical apparent density0.30.30.9-0.60.20.2-0.2-0.3-0.3-0.8-0.60.3-1.00.80.70.6-0.50.90.6
Bone: cortical area2.33.56.21.2-1.9-1.92.02.01.90.62.5-2.51.71.61.61.9-2.2-1.82.0
Bone: cortical porosity2.22.45.5-0.7-1.0-1.00.91.31.0-1.31.4-1.40.52.32.32.2-2.2-1.02.3
Bone: cortical porosity3.13.38.0-1.1-1.1-1.10.91.21.0-1.91.5-1.60.52.82.72.6-2.6-0.82.8
Bone: cortical thickness1.21.93.01.2-1.4-1.41.51.31.40.71.7-1.71.41.11.11.3-1.5-1.41.5
Bone: cortical thickness0.30.40.9-0.0-0.5-0.50.40.60.4-0.30.4-0.3-0.60.90.90.9-0.9-0.10.9
Bone: cortical tissue density0.30.30.9-0.60.20.2-0.2-0.3-0.3-0.8-0.60.3-0.90.80.70.6-0.50.90.6
Condit. Reinf. active minus inactive responses0.10.20.60.7-0.4-0.40.50.40.30.80.4-0.2-0.2-0.2-0.2-0.2-0.10.4-0.4
Condit. Reinf. active-inactive response ratio2.02.24.01.8-1.9-1.92.01.91.81.41.8-1.70.90.80.80.8-1.2-0.50.8
Condit. Reinf. active responses0.10.11.00.20.10.1-0.1-0.1-0.20.40.00.2-0.6-0.3-0.4-0.30.11.0-0.6
Condit. Reinf. inactive responses1.61.93.0-1.11.51.5-1.7-1.6-1.7-0.6-1.51.7-1.4-1.1-1.2-1.11.21.6-1.3
Incentive salience index mean0.60.71.71.0-1.0-1.01.11.30.90.81.2-1.10.70.20.30.4-0.7-0.1-0.1
Condit. Reinf. lever presses1.82.44.61.5-1.9-1.91.92.11.81.22.1-2.01.80.60.71.1-1.3-0.50.3
Condit. Reinf. active minus inactive responses0.70.92.50.90.10.1-0.2-0.4-0.31.3-0.30.4-0.7-1.5-1.6-1.41.10.8-1.5
Condit. Reinf. active-inactive response ratio2.02.17.82.4-0.8-0.80.80.30.62.80.2-0.20.1-2.0-2.0-1.81.30.7-1.9
Condit. Reinf. active responses0.70.91.9-0.30.80.8-1.0-1.0-1.00.2-0.60.8-0.8-1.2-1.4-1.30.91.1-1.3
Condit. Reinf. inactive responses0.81.03.5-1.91.11.1-1.3-1.1-1.2-1.7-0.60.8-0.50.50.30.1-0.10.40.4
Condit. Reinf. lever presses0.71.03.10.80.30.3-0.2-0.6-0.21.30.00.00.1-1.8-1.7-1.51.20.4-1.6
Condit. Reinf. lever reinforcers received0.40.61.2-0.30.60.6-0.8-0.9-0.80.1-0.40.6-0.7-1.0-1.1-1.00.71.0-1.0
Conditioned reinforcement - actives0.10.10.60.10.10.1-0.1-0.10.10.2-0.30.30.1-0.6-0.5-0.80.6-0.2-0.6
Conditioned reinforcement - inactives0.20.20.4-0.60.10.1-0.6-0.2-0.3-0.5-0.00.10.4-0.4-0.3-0.60.6-0.6-0.5
Conditioned locomotion0.20.20.8-0.2-0.4-0.40.30.50.3-0.40.3-0.30.10.90.70.5-0.6-0.60.8
Patch foraging indifference point 0 sec0.10.10.40.3-0.1-0.10.20.00.40.4-0.20.2-0.60.10.00.00.1-0.60.4
Patch foraging indifference point AUC1.01.13.0-1.3-0.4-0.40.0-0.0-0.0-1.70.2-0.10.11.71.71.5-1.30.31.6
Delay disc. indifference point, 0s delay1.51.63.3-0.61.51.5-1.4-1.5-1.7-0.1-1.21.2-0.9-1.2-1.3-1.21.11.8-1.4
Delay disc. indifference point, 16s delay0.40.41.11.0-0.5-0.50.40.30.41.10.7-0.60.6-0.5-0.6-0.3-0.10.7-0.5
Delay disc. indifference point, 2s delay0.50.62.21.4-0.2-0.20.60.40.41.50.6-0.40.8-0.9-0.7-0.40.40.5-1.1
Delay disc. indifference point, 24s delay0.50.51.5-1.00.10.1-0.3-0.1-0.1-1.2-0.30.5-0.70.90.91.1-0.70.80.6
Delay disc. indifference point, 4s delay2.42.56.2-0.41.71.7-1.6-1.6-1.80.3-1.21.3-1.0-1.9-1.8-1.51.42.5-2.2
Delay disc. indifference point, 8s delay0.20.20.6-0.70.40.4-0.6-0.5-0.6-0.7-0.30.4-0.30.0-0.1-0.00.00.7-0.2
Indifference point function ln k1.01.44.31.70.10.10.20.30.12.1-0.20.1-0.1-2.0-1.7-1.41.5-0.8-1.8
Indifference point function log k1.01.44.31.70.10.10.20.30.12.1-0.20.1-0.1-2.0-1.7-1.41.5-0.8-1.8
Patch foraging total patch changes 0 sec0.10.20.50.6-0.5-0.50.50.30.70.70.3-0.2-0.20.10.10.2-0.1-0.70.4
Patch foraging total patch changes 12 sec2.33.07.5-1.5-1.1-1.10.60.90.9-2.11.0-0.90.92.72.72.7-2.2-0.82.6
Patch foraging total patch changes 18 sec0.30.41.5-0.5-0.5-0.50.20.10.2-0.70.10.0-0.31.01.00.9-0.7-0.41.2
Patch foraging total patch changes 24 sec0.20.20.6-0.8-0.0-0.0-0.3-0.5-0.1-0.8-0.20.1-0.60.60.40.3-0.30.40.6
Patch foraging total patch changes 6 sec0.20.31.3-0.50.00.0-0.2-0.3-0.1-0.6-0.10.2-0.60.90.70.5-0.6-0.21.1
Patch foraging time to switch 0 sec1.92.96.6-2.61.91.9-2.2-1.6-2.1-2.3-1.81.7-2.00.3-0.0-0.20.32.1-0.1
Patch foraging water rate 0 sec1.22.06.22.5-1.5-1.51.60.91.62.41.1-1.01.4-1.0-0.8-0.50.5-1.4-0.6
Patch foraging water rate 12 sec1.72.59.02.9-1.2-1.21.91.21.53.01.2-1.21.4-1.2-1.1-0.90.6-1.8-0.8
Patch foraging water rate 18 sec2.53.48.22.9-2.1-2.12.41.82.52.61.9-1.92.2-0.4-0.20.1-0.1-1.8-0.1
Patch foraging water rate 24 sec1.01.44.92.1-0.8-0.81.20.41.12.20.7-0.71.3-1.4-1.2-1.00.9-0.3-1.2
Patch foraging water rate 6 sec1.92.810.23.1-1.3-1.31.71.01.63.21.3-1.31.7-1.6-1.5-1.10.9-1.3-1.2
Seeking ratio, delayed vs. immediate footshock2.02.35.9-1.90.40.4-0.6-0.5-0.6-2.30.10.0-1.42.42.01.6-2.11.12.4
Distance traveled before self-admin1.71.82.61.0-1.6-1.61.51.61.40.61.5-1.61.31.11.31.0-1.2-1.21.4
Distance traveled after self-admin0.20.20.7-0.1-0.2-0.20.30.50.3-0.2-0.0-0.10.30.60.70.6-0.3-0.20.9
Extensor digitorum longus weight2.28.513.33.5-3.6-3.63.63.53.52.83.6-3.63.60.50.91.6-1.6-2.40.8
Bone: elastic displacement2.83.14.40.8-2.1-2.11.92.02.00.01.8-1.91.11.81.91.9-1.8-1.72.1
Bone: elastic work1.41.93.00.8-1.6-1.61.51.61.60.31.6-1.70.91.11.21.2-1.3-1.51.5
Bone: endosteal estimation0.40.82.00.9-1.0-1.01.01.31.00.81.4-1.31.20.40.30.3-0.7-0.50.3
Bone: endosteal perimeter1.43.06.10.9-1.8-1.81.82.11.80.32.5-2.31.71.51.51.7-1.9-1.31.5
Epididymis fat weight0.71.63.41.4-1.8-1.81.51.31.61.11.5-1.41.30.70.60.4-0.7-0.80.6
Delta time in closed arm before/after self-admin1.21.12.9-1.40.20.2-0.20.1-0.3-1.70.7-0.80.61.61.31.4-1.7-0.41.6
Delta time in open arm before/after self-admin0.30.31.0-0.40.70.7-0.3-0.5-0.3-0.4-1.01.00.00.20.30.10.3-0.50.7
Diff in mean of infusions in LGA sessions0.40.51.4-0.40.70.7-0.9-0.5-0.8-0.2-0.40.3-1.2-0.8-1.1-0.90.40.5-0.7
Delay discount exponential model param0.40.41.90.3-0.7-0.70.70.60.70.00.5-0.70.40.60.60.3-0.4-1.40.9
Extinction: sum of active levers before priming1.41.43.6-1.2-0.6-0.60.10.40.5-1.70.5-0.60.31.81.81.9-1.3-1.01.7
Active lever presses in extinction session 60.80.82.8-1.3-0.3-0.3-0.10.20.1-1.70.2-0.2-0.21.31.31.5-0.90.11.2
Bone: final force0.30.62.61.4-0.4-0.40.50.50.41.60.7-0.80.3-0.8-0.8-0.60.1-0.3-0.5
Bone: final moment0.60.94.31.8-0.5-0.50.70.60.62.10.8-0.90.5-1.1-1.0-0.80.3-0.5-0.7
Food consumed during 24 hour testing period1.01.22.3-0.21.11.1-1.3-1.5-1.00.3-0.90.8-0.4-1.4-1.5-1.41.50.4-1.2
Glucose0.20.30.90.2-0.6-0.60.50.30.60.10.9-0.90.70.40.20.2-0.60.30.4
Heart weight0.50.71.70.7-0.9-0.91.00.71.30.50.9-0.91.20.30.40.4-0.3-1.30.6
Delay discount hyperbolic model param0.40.41.80.0-0.7-0.70.60.50.6-0.20.4-0.60.20.80.70.4-0.5-1.31.1
Intermittent access intake day 1-15 change0.20.20.60.6-0.4-0.40.20.00.30.80.2-0.10.6-0.6-0.5-0.50.5-0.3-0.5
Intermittent access intake escalation0.10.10.50.5-0.5-0.50.30.30.40.50.4-0.30.7-0.1-0.0-0.00.0-0.2-0.2
Intermittent access intake escalation 20.30.30.5-0.30.50.5-0.7-0.6-0.6-0.1-0.40.4-0.6-0.7-0.7-0.50.60.3-0.7
Intermitt. access day 1 inactive lever presses1.41.54.2-1.1-0.7-0.70.10.80.5-1.50.9-0.90.62.12.01.7-1.5-0.61.8
Intermitt. access day 15 inactive lever presses0.40.41.2-0.8-0.3-0.3-0.10.70.1-1.10.9-0.90.20.50.70.7-0.8-0.50.4
Intermitt. access escalation Index0.90.82.1-0.50.60.6-0.9-0.6-0.8-0.2-0.80.8-0.8-1.3-1.2-1.01.20.6-1.4
Intermittent access day 1 total infusions0.00.00.3-0.2-0.2-0.20.00.40.1-0.2-0.00.00.20.10.1-0.10.0-0.6-0.1
Intermittent access day 15 total infusions0.30.41.50.8-0.6-0.60.50.40.60.90.3-0.31.2-0.5-0.5-0.50.4-0.7-0.5
Intermittent access terminal intake (last 3 days)0.30.30.90.6-0.5-0.50.30.40.50.70.3-0.30.9-0.6-0.6-0.50.5-1.0-0.6
Intermittent access total infusions0.10.10.4-0.2-0.3-0.30.00.30.2-0.20.2-0.10.60.20.10.1-0.1-0.60.0
Intermittent access day 1 locomotion0.10.20.5-0.0-0.3-0.30.30.60.3-0.20.00.00.50.60.50.3-0.2-0.70.4
Intermittent access day 15 total locomotion0.10.10.3-0.3-0.3-0.30.10.30.2-0.30.3-0.20.10.60.40.3-0.50.30.3
Intermittent access total locomotion0.40.41.4-1.0-0.2-0.2-0.20.3-0.0-1.1-0.00.0-0.01.21.00.8-0.70.00.8
Intermittent access standard deviation0.30.40.90.8-0.4-0.40.60.60.50.90.9-0.90.8-0.3-0.4-0.3-0.3-0.1-0.4
Left kidney weight3.29.114.83.2-3.6-3.63.93.73.82.23.4-3.43.61.31.51.8-1.7-3.61.7
Right kidney weight3.08.316.93.0-3.4-3.43.53.63.62.23.1-3.13.41.11.31.6-1.3-4.11.6
Cocaine induced anxiety0.70.83.1-1.60.70.7-1.1-0.4-0.8-1.8-0.10.1-1.00.80.60.7-0.60.50.6
Post-drug Anxiety0.20.20.7-0.80.10.1-0.6-0.0-0.4-0.80.4-0.50.00.40.40.4-0.6-0.20.5
Baseline Anxiety0.40.41.10.3-0.7-0.70.70.30.60.20.6-0.61.00.50.70.4-0.4-1.10.8
Tail length1.03.18.12.2-0.2-0.20.2-0.20.22.8-0.91.20.5-2.8-2.5-2.22.8-0.9-2.6
Length with tail0.62.16.82.3-0.8-0.81.00.90.92.50.4-0.21.3-1.7-1.4-1.31.6-2.6-1.1
Length without tail1.32.710.91.5-1.7-1.71.72.01.81.22.0-2.01.70.40.60.5-0.6-3.30.9
Times rat made contact with spout0.40.52.00.7-0.4-0.40.60.50.60.61.0-1.11.3-0.2-0.00.2-0.3-1.40.2
Lifetime Intake0.00.00.2-0.3-0.2-0.2-0.00.20.1-0.30.00.00.30.10.1-0.00.0-0.4-0.0
Liver weight, left0.30.51.81.1-0.1-0.10.30.10.11.30.1-0.2-0.1-1.0-1.0-1.00.70.6-1.1
Liver weight, right1.01.63.61.2-1.7-1.71.51.91.60.91.6-1.71.20.40.60.8-1.1-0.30.2
Locomotor activity0.71.14.52.1-1.1-1.11.30.61.41.90.3-0.30.9-0.6-0.5-0.50.7-1.1-0.3
Locomotor testing distance0.40.62.81.7-0.8-0.81.00.41.01.60.3-0.30.6-0.3-0.3-0.20.4-0.5-0.1
Locomotor testing rearing0.60.92.31.4-1.1-1.11.10.81.31.20.9-0.91.5-0.00.10.2-0.1-1.00.1
Locomotion in novel chamber1.21.53.8-0.61.41.4-1.1-1.5-1.5-0.2-1.31.3-1.5-0.7-1.3-1.20.71.9-0.7
Locomotion in novel chamber post-restriction1.21.52.7-0.31.11.1-1.0-1.3-1.00.4-1.41.5-1.6-1.4-1.4-1.31.50.6-1.5
Fecal boli incidents, locomotor time 10.70.82.01.4-1.1-1.11.20.61.21.21.0-1.01.10.10.00.1-0.4-0.40.5
Change in fecal boli incidents, locomotor task0.50.50.90.8-0.8-0.80.91.00.80.70.3-0.30.70.60.50.5-0.3-0.80.6
Time >=10cm from walls, locomotor time 10.60.61.6-0.6-0.6-0.60.30.90.4-1.01.0-0.90.50.81.11.3-1.0-0.20.6
Bouts of movement, locomotor time 10.40.41.80.3-0.0-0.0-0.20.0-0.10.5-0.30.2-0.5-1.3-1.1-0.80.90.1-1.3
Total resting periods, locomotor time 10.40.41.60.7-0.2-0.20.20.30.10.9-0.0-0.0-0.1-1.3-1.0-0.80.8-0.2-1.2
Rest time, locomotor task time 12.02.24.70.8-1.7-1.71.71.91.80.22.0-2.21.70.81.11.3-1.5-1.00.9
Distance moved, locomotor task time 10.50.51.3-0.20.80.8-0.7-0.9-0.80.1-1.01.1-0.8-0.2-0.5-0.60.61.1-0.4
Vertical activity count, locomotor time 11.01.12.1-1.11.21.2-1.4-1.4-1.4-0.8-1.21.1-1.30.0-0.3-0.50.31.5-0.1
Time >=10cm from walls, locomotor time 20.30.31.3-0.80.50.5-0.20.0-0.5-0.90.2-0.2-0.50.20.40.5-0.71.1-0.1
Bouts of movement, locomotor time 20.50.61.20.1-1.1-1.10.60.70.8-0.10.9-0.71.10.70.80.9-0.8-0.40.6
Total resting periods, locomotor time 20.60.61.30.1-1.1-1.10.60.80.9-0.00.9-0.81.10.60.70.8-0.6-0.70.5
Rest time, locomotor task time 20.10.10.4-0.4-0.3-0.30.20.30.4-0.60.3-0.40.40.20.50.6-0.3-0.30.2
Distance moved, locomotor task time 20.50.61.8-0.10.90.9-0.6-0.7-1.00.2-0.60.7-1.0-0.4-0.8-0.80.31.3-0.6
Vertical activity count, locomotor time 20.50.51.3-0.90.90.9-0.8-0.8-1.1-0.8-0.50.5-0.90.50.2-0.1-0.30.50.6
Light reinforcement 10.30.51.30.90.10.10.2-0.20.01.0-0.00.10.9-1.2-1.1-0.90.8-0.2-1.1
Light reinforcement 20.30.41.10.8-0.1-0.10.30.40.10.90.4-0.5-0.1-1.0-1.0-0.70.4-0.3-1.0
Bone: marrow area0.41.02.31.0-1.1-1.11.11.41.10.81.5-1.41.20.40.40.4-0.7-0.70.3
Bone: maximum diameter3.87.011.61.5-2.8-2.82.92.92.80.73.4-3.32.52.42.42.7-3.0-2.12.7
Bone: maximum force0.20.31.00.6-0.4-0.40.40.70.40.60.9-0.90.30.20.20.3-0.5-1.00.6
Bone: maximum moment0.30.61.41.0-0.6-0.60.70.90.61.01.1-1.10.60.10.10.2-0.4-1.20.5
Mean time between licks in bursts0.40.61.5-0.1-0.5-0.50.50.90.5-0.50.9-1.10.40.91.01.0-1.2-0.30.8
Mean num. licks in bursts1.51.82.90.2-1.2-1.21.21.11.3-0.31.4-1.51.61.61.61.6-1.5-1.41.7
Cd content in liver0.10.10.3-0.40.60.6-0.2-0.0-0.5-0.30.1-0.30.40.00.10.1-0.3-0.30.2
Co content in liver0.80.92.6-0.7-0.4-0.40.50.70.5-1.10.8-0.90.61.61.51.5-1.60.50.8
Cu content in liver1.41.73.8-0.21.41.4-1.4-1.1-1.40.4-0.80.8-0.7-1.7-1.7-1.71.40.9-2.0
Fe content in liver0.91.13.00.30.90.9-0.8-0.9-0.80.8-0.70.7-0.1-1.7-1.6-1.51.5-0.0-1.4
K content in liver0.20.20.60.3-0.5-0.50.50.50.50.30.6-0.30.00.10.20.1-0.40.8-0.3
Mg content in liver0.10.10.20.1-0.4-0.40.30.50.30.00.5-0.30.00.30.30.2-0.40.10.1
Mn content in liver1.61.83.50.5-1.4-1.41.41.51.4-0.11.9-1.71.41.21.41.3-1.6-0.71.2
Na content in liver0.10.10.6-0.30.20.2-0.3-0.2-0.3-0.2-0.40.5-0.8-0.2-0.1-0.40.30.60.3
Rb content in liver0.20.20.80.6-0.0-0.0-0.1-0.20.00.9-0.10.20.3-0.8-0.7-0.60.8-0.0-0.8
Se content in liver0.81.01.7-0.81.11.1-1.2-1.1-1.1-0.4-1.21.3-1.1-0.8-0.8-1.01.00.5-1.0
Sr content in liver0.60.51.20.10.70.7-0.5-0.6-0.70.4-0.50.5-0.3-1.0-0.9-0.90.71.1-0.9
Zn content in liver0.00.00.1-0.30.20.2-0.3-0.2-0.1-0.2-0.10.2-0.10.1-0.0-0.10.20.1-0.1
Bone: minimum diameter0.30.51.80.6-0.5-0.50.60.70.50.51.1-1.00.70.40.30.4-0.8-1.30.8
Time in familiar zone, hab. session 14.54.26.8-0.92.12.1-2.2-2.2-2.1-0.2-2.62.6-2.4-2.0-2.1-2.22.21.4-2.0
Time in novel zone, hab. session 13.53.45.31.2-2.0-2.02.12.12.00.62.2-2.22.31.61.81.8-1.6-1.71.7
Total zone transitions, hab. session 13.24.57.01.5-2.7-2.72.62.42.30.82.6-2.52.01.92.02.0-2.50.01.5
Total locomotion distance, hab. session 12.02.85.21.4-2.3-2.32.11.92.00.81.8-1.71.31.61.71.6-1.7-0.41.4
Locomotion velocity, hab. session 12.73.86.31.2-2.5-2.52.32.12.10.52.1-2.11.52.12.12.1-2.3-0.11.8
Time in familiar zone, hab. session 20.50.51.6-1.20.70.7-0.8-0.9-0.5-1.3-0.80.8-0.10.30.50.30.3-0.40.5
Time in novel zone, hab. session 21.51.52.81.6-1.4-1.41.71.61.41.31.5-1.60.70.40.40.6-1.0-0.30.4
Total zone transitions, hab. session 23.03.86.31.5-2.5-2.52.42.42.30.92.4-2.52.01.41.61.7-2.0-0.61.1
Total locomotion distance, hab. session 21.52.03.91.2-2.0-2.01.81.71.80.71.5-1.51.11.11.31.4-1.2-0.40.8
Locomotion velocity, hab. session 21.52.14.01.1-2.0-2.01.71.81.70.61.5-1.51.01.21.41.5-1.4-0.40.9
Novel to familiar place preference ratio0.50.52.2-0.5-0.4-0.40.30.20.3-0.80.3-0.3-0.41.21.00.9-0.8-0.51.5
Novelty place preference0.40.41.6-0.0-0.6-0.60.50.40.5-0.30.5-0.5-0.21.00.80.8-0.7-0.71.3
Time in novel zone, NPP test0.60.71.70.4-0.9-0.90.90.70.80.00.8-0.70.01.00.80.9-0.7-1.11.3
Total zone transitions, NPP test6.69.415.62.8-3.9-3.93.94.03.71.83.6-3.63.21.92.32.4-2.5-2.11.8
Total locomotion distance, NPP test4.05.510.42.7-3.2-3.23.13.03.02.02.7-2.52.31.11.41.6-1.6-1.10.8
Locomotion velocity, NPP test2.94.17.72.2-2.8-2.82.62.62.51.52.3-2.22.01.11.41.5-1.5-0.80.8
Intraocular pressure1.01.53.71.9-1.3-1.31.31.21.31.91.3-1.31.2-0.6-0.5-0.10.1-1.5-0.3
Delta distance traveled before/after self-admin0.90.91.8-1.31.21.2-1.1-1.0-1.0-1.2-1.31.3-0.80.1-0.1-0.10.51.00.0
Delta ambulatory time before/after self-admin0.70.81.6-1.01.01.0-1.0-0.9-0.9-0.9-1.31.3-0.9-0.1-0.3-0.30.51.2-0.4
Parametrial fat weight0.61.33.30.60.90.9-0.6-0.9-0.91.1-0.70.60.1-1.8-1.7-1.51.50.5-1.7
Pavlov. Cond. lever latency1.31.63.1-0.11.31.3-1.1-1.8-1.20.3-1.51.4-0.9-1.4-1.4-1.61.60.6-1.2
Pavlov. Cond. magazine entry latency2.12.74.70.9-1.7-1.71.72.11.60.42.2-2.02.11.31.41.7-1.8-1.11.2
Pavlov. Cond. change in total contacts0.60.61.2-0.2-0.7-0.70.61.00.6-0.41.1-0.90.90.90.91.1-1.1-0.30.6
Pavlov. Cond. index score1.82.33.80.3-1.6-1.61.41.91.4-0.21.8-1.81.51.61.71.9-1.9-0.71.4
Pavlov. Cond. latency score1.92.44.20.5-1.7-1.71.52.11.6-0.01.9-1.81.61.51.61.8-1.8-1.01.3
Pavlov. Cond. lever contacts1.72.03.9-0.1-1.4-1.41.11.81.2-0.61.5-1.51.01.81.82.0-1.8-0.61.5
Pavlov. Cond. magazine entry number0.91.22.2-0.11.11.1-0.9-1.5-0.90.2-1.41.4-1.0-1.1-1.2-1.41.50.4-0.8
Pavlov. Cond. intertrial magazine entries2.73.24.8-1.32.22.2-2.1-2.1-2.1-0.7-2.02.1-2.1-1.5-1.7-2.01.90.3-1.1
Pavlov. Cond. lever-magazine prob. diff.1.62.03.60.0-1.3-1.31.21.81.2-0.51.7-1.71.41.71.71.9-1.9-0.61.4
Pavlov. Cond. response bias0.50.61.5-0.1-0.6-0.60.51.20.4-0.21.1-1.10.70.80.81.0-1.2-0.00.5
Pavlov. Cond. lever latency0.40.61.3-0.71.01.0-0.9-0.6-1.0-0.4-0.90.8-1.1-0.5-0.5-0.60.50.7-0.7
Pavlov. Cond. magazine entry latency1.41.64.20.8-1.4-1.41.41.51.40.41.6-1.41.50.80.91.0-0.9-2.01.1
Pavlov. Cond. change in total contacts1.41.93.81.8-1.8-1.81.81.21.81.51.5-1.42.00.10.30.4-0.4-1.20.4
Pavlov. Cond. index score0.50.61.60.8-0.9-0.90.90.81.00.61.0-0.81.10.10.30.3-0.2-1.30.3
Pavlov. Cond. latency score0.60.82.10.8-1.0-1.01.00.91.00.61.0-0.91.20.20.40.5-0.3-1.50.4
Pavlov. Cond. lever contacts0.40.61.40.7-0.9-0.90.90.70.90.51.0-0.91.20.30.40.5-0.4-1.00.5
Pavlov. Cond. magazine entry number0.60.71.7-0.50.90.9-0.9-1.1-0.9-0.3-1.31.1-1.1-0.5-0.6-0.60.81.0-0.6
Pavlov. Cond. intertrial magazine entries3.74.810.4-2.52.52.5-2.8-2.6-2.7-1.9-2.52.6-3.2-0.6-1.0-1.21.12.2-0.7
Pavlov. Cond. lever-magazine prob. diff.0.70.92.20.8-1.1-1.11.11.01.10.61.2-1.01.30.30.50.5-0.5-1.50.5
Pavlov. Cond. response bias0.50.71.60.4-1.0-1.00.90.80.90.31.3-1.11.30.50.60.7-0.7-0.70.7
Time in closed arm before self-admin1.51.74.51.9-0.2-0.20.2-0.00.22.1-0.90.9-0.7-2.0-1.7-1.52.00.3-1.9
Time in closed arm after self-admin0.20.20.30.6-0.6-0.60.50.50.50.40.4-0.40.4-0.10.00.3-0.0-0.5-0.1
Time in open arm before self-admin0.10.20.8-0.60.20.2-0.3-0.4-0.3-0.50.3-0.40.20.2-0.1-0.1-0.50.90.1
Time in open arm after self-admin1.01.13.4-1.81.31.3-1.1-1.1-1.1-1.7-1.11.1-0.50.70.70.4-0.30.40.9
Bone: periosteal estimation1.32.75.71.4-1.7-1.71.92.01.71.02.4-2.31.81.11.01.2-1.7-1.31.3
Bone: periosteal perimeter2.74.47.70.6-2.0-2.01.92.11.9-0.12.8-2.82.02.22.22.4-2.7-1.82.5
Bone: post-yield work0.30.40.90.20.80.8-0.5-0.4-0.70.4-0.10.1-0.3-0.8-0.9-0.80.50.5-0.9
Progressive ratio test 1 active lever presses0.10.10.3-0.3-0.1-0.10.10.20.3-0.4-0.20.30.10.50.60.4-0.0-0.50.3
Progressive ratio test 1 breakpoint0.30.30.8-0.2-0.5-0.50.40.50.6-0.50.1-0.00.40.80.90.8-0.4-0.70.7
Progressive ratio test 1 inactive lever presses0.40.42.2-1.3-0.1-0.1-0.40.1-0.1-1.5-0.10.20.10.80.80.7-0.2-0.70.6
Progressive ratio test 2 active lever presses0.20.20.60.1-0.8-0.80.40.60.60.10.7-0.60.60.30.10.1-0.3-0.30.2
Progressive ratio test 2 breakpoint0.00.00.20.0-0.4-0.40.10.20.30.10.3-0.30.30.0-0.1-0.2-0.00.0-0.1
Progressive ratio test 2 inactive lever presses0.20.30.6-0.60.50.5-0.8-0.4-0.5-0.3-0.40.4-0.2-0.5-0.6-0.70.7-0.2-0.7
Incentive Sensitization - Responses0.50.51.50.6-0.8-0.80.50.60.60.61.2-1.21.1-0.4-0.6-0.4-0.40.0-0.4
Incentive Sensitization - Breakpoint0.50.51.40.6-0.8-0.80.40.60.60.71.2-1.21.0-0.4-0.6-0.4-0.30.1-0.5
Sum of active levers in priming session hrs 5-61.81.73.3-0.5-1.1-1.10.91.21.1-1.21.3-1.30.81.71.71.8-1.6-1.21.7
Progressive ratio1.72.04.21.6-1.7-1.72.11.71.61.21.7-1.61.11.01.00.8-1.3-0.61.1
Food seeking constrained by brief footshock0.30.41.3-0.2-0.1-0.10.30.60.3-0.50.8-0.80.30.80.81.0-1.20.30.6
Seeking ratio, punishment vs. effort0.60.82.1-1.41.11.1-1.5-0.8-1.0-1.2-0.70.5-0.6-0.5-0.5-0.20.40.8-0.7
Retroperitoneal fat weight0.82.78.42.9-1.8-1.81.81.41.82.81.2-1.31.6-1.2-1.0-0.80.7-0.9-1.1
Reaction time number correct0.00.10.20.2-0.0-0.0-0.1-0.20.00.2-0.20.30.3-0.1-0.3-0.30.5-0.4-0.0
Reaction time mean minus median0.30.51.0-0.6-0.5-0.50.10.60.3-0.80.4-0.40.20.91.00.9-0.7-1.00.9
Reaction time mean minus median AUC0.40.51.10.2-0.8-0.80.60.80.7-0.10.8-0.80.90.40.70.7-0.5-1.00.5
Reaction time num false alarms0.50.71.2-0.71.11.1-1.0-1.1-0.9-0.5-1.11.0-0.9-0.3-0.4-0.50.7-0.0-0.2
Reaction time num false alarms AUC0.91.22.3-1.21.51.5-1.4-1.3-1.3-0.9-1.41.4-1.3-0.3-0.4-0.50.80.1-0.2
Reaction time trials correct on left0.00.10.20.2-0.0-0.0-0.1-0.20.00.2-0.20.30.3-0.1-0.3-0.30.5-0.4-0.0
Reaction time trials on left0.00.10.20.2-0.0-0.0-0.1-0.30.00.2-0.20.30.3-0.1-0.3-0.20.4-0.40.0
Reaction time mean0.10.10.3-0.20.10.1-0.00.3-0.1-0.30.4-0.50.40.10.20.2-0.4-0.40.1
Reaction time mean AUC0.00.10.2-0.30.40.4-0.3-0.1-0.4-0.30.1-0.20.2-0.2-0.1-0.2-0.0-0.1-0.2
Median of all reaction times0.10.10.3-0.20.50.5-0.3-0.1-0.5-0.10.2-0.30.3-0.4-0.4-0.3-0.00.2-0.4
Reaction time omissions0.20.31.2-0.90.30.3-0.4-0.3-0.2-1.1-0.20.2-0.60.80.50.5-0.40.80.5
Reaction time false alarm rate0.50.71.5-0.71.21.2-1.0-0.9-1.0-0.5-1.01.0-1.2-0.4-0.4-0.50.60.2-0.4
Reaction time premature initiation rate0.30.41.20.10.70.7-0.5-0.4-0.80.3-0.40.3-0.6-1.1-0.8-0.70.50.4-1.1
Reaction time premature initiations0.10.20.50.00.50.5-0.4-0.3-0.60.2-0.30.3-0.5-0.7-0.5-0.40.40.1-0.7
Std. dev. reaction times0.10.10.3-0.5-0.1-0.1-0.10.1-0.1-0.60.1-0.3-0.10.50.50.5-0.4-0.50.6
Reaction time trials completed0.00.10.20.2-0.0-0.0-0.1-0.30.00.2-0.20.30.3-0.1-0.3-0.20.4-0.40.0
Reaction time trials AUC0.00.10.2-0.10.10.1-0.3-0.4-0.10.0-0.30.40.2-0.1-0.3-0.30.5-0.4-0.0
Run reversals in cocaine runway, females0.30.31.20.3-0.0-0.00.20.00.20.3-0.50.60.1-0.7-0.5-0.30.71.0-1.1
Run reversals in cocaine runway, males0.80.84.10.7-0.6-0.60.71.30.60.51.3-1.30.9-0.00.30.3-0.5-2.00.3
Latency to leave start box in cocaine runway2.32.55.3-1.91.91.9-2.3-1.8-2.2-1.4-1.71.6-1.7-0.6-0.8-1.00.91.3-0.7
Latency to leave start box in cocaine runway, F1.21.32.4-0.61.21.2-1.5-1.4-1.5-0.2-1.51.5-1.2-0.8-0.8-1.11.20.8-0.9
Latency to leave start box in cocaine runway, M2.02.04.5-2.11.71.7-1.8-1.3-1.8-1.8-1.10.9-1.3-0.4-0.8-0.60.11.9-0.6
Std. dev. time between licks in bursts0.60.82.1-1.20.20.2-0.2-0.1-0.2-1.50.2-0.2-0.31.41.10.9-1.31.11.2
Total sessions with >9 infusions0.10.10.30.2-0.1-0.10.1-0.00.10.2-0.30.30.3-0.3-0.2-0.30.4-0.5-0.2
Short access day 1 total inactive lever presses1.21.45.9-2.20.60.6-1.0-0.3-0.7-2.4-0.60.6-0.51.51.51.3-0.90.21.1
Short access day 10 total inactive lever presses1.61.73.9-0.9-0.8-0.80.41.10.5-1.41.2-1.30.52.01.91.9-1.8-0.92.0
Short access day 1 total infusions0.20.21.1-0.90.30.3-0.4-0.2-0.2-1.1-0.50.6-0.10.20.40.40.1-0.40.2
Short access day 10 total infusions0.20.20.8-0.1-0.7-0.70.40.40.7-0.30.4-0.30.90.30.40.2-0.1-0.80.2
Short access total infusions0.20.21.0-0.90.00.0-0.1-0.0-0.0-1.0-0.30.3-0.10.60.60.4-0.2-0.10.4
Short access day 1 locomotion0.50.61.6-1.00.10.1-0.3-0.7-0.2-1.3-0.60.7-0.21.01.00.9-0.41.10.8
Short access day 10 total locomotion1.41.54.1-1.0-0.9-0.90.30.90.5-1.50.9-0.9-0.12.01.91.7-1.7-0.11.8
Short access total locomotion0.60.61.9-0.6-0.8-0.80.40.50.5-1.00.3-0.30.31.41.31.1-0.8-0.11.1
One hour access (0.3 mA shock)0.60.71.3-0.60.80.8-1.1-0.9-0.7-0.3-0.80.8-0.5-0.9-1.0-1.11.1-0.1-0.8
Compulsive drug intake1.41.53.3-0.61.41.4-1.2-1.8-1.3-0.2-1.61.6-0.7-0.7-1.0-1.11.31.3-0.7
One hour access (shock baseline)0.20.20.6-0.20.10.1-0.50.1-0.20.00.1-0.2-0.2-0.7-0.7-0.60.4-0.5-0.8
Social response proportion0.30.40.9-0.90.80.8-0.6-0.4-0.6-0.9-0.60.6-1.00.40.20.00.0-0.10.4
Social responses0.00.10.1-0.20.30.3-0.2-0.2-0.2-0.20.2-0.00.1-0.3-0.3-0.30.00.3-0.3
Social time0.10.10.5-0.40.70.7-0.5-0.5-0.4-0.3-0.30.2-0.2-0.1-0.1-0.00.1-0.50.1
Soleus weight1.44.111.13.3-2.4-2.42.52.02.33.22.2-2.12.2-0.9-0.8-0.7-0.1-0.5-0.8
Bone: stiffness0.10.20.4-0.60.70.7-0.6-0.1-0.7-0.30.1-0.2-0.5-0.2-0.10.0-0.2-0.1-0.1
Tibialis anterior weight1.03.48.22.9-2.2-2.22.42.02.32.61.6-1.62.2-0.4-0.10.3-0.0-2.10.0
Time to tail flick, vehicle, before self-admin0.40.41.10.7-0.1-0.10.1-0.30.01.00.0-0.10.8-1.0-0.9-0.70.70.0-1.1
Time to tail flick, vehicle, after self-admin0.80.93.50.4-1.0-1.01.01.31.00.10.8-0.71.40.60.80.7-0.3-1.90.4
Time to tail flick, test, before self-admin1.11.12.60.10.90.9-0.9-1.0-0.70.5-0.70.6-0.5-1.4-1.6-1.51.01.3-1.6
Time to tail flick, test, after self-admin2.32.47.32.5-0.8-0.81.10.60.92.70.7-0.72.1-2.0-1.5-1.61.3-1.3-1.8
Delta time to tail flick, vehicle, before/after SA0.80.81.9-0.4-0.7-0.70.71.20.6-0.80.6-0.50.31.31.41.3-0.9-1.10.9
Delta time to tail flick, test, before/after SA1.41.34.31.9-0.8-0.80.90.50.72.10.4-0.31.5-1.2-0.9-0.81.1-1.5-0.9
Tibia length1.33.813.93.3-1.0-1.01.21.11.03.70.4-0.51.2-2.7-2.5-2.01.9-0.9-2.6
Ambulatory time before self-admin1.41.52.41.0-1.5-1.51.41.41.40.71.5-1.51.10.80.90.8-1.0-0.91.2
Ambulatory time after self-admin0.10.20.6-0.2-0.2-0.20.20.40.2-0.4-0.20.2-0.10.70.70.5-0.20.20.8
Bone: tissue strength1.71.74.61.70.10.10.1-0.40.02.1-0.20.20.7-2.1-1.9-1.81.8-0.2-1.9
Total heroin consumption0.30.43.00.4-0.1-0.10.30.70.40.30.7-0.80.9-0.5-0.10.40.2-1.7-0.0
Bone: trabecular number0.81.22.2-1.41.41.4-1.3-1.1-1.5-1.3-1.01.0-1.40.2-0.0-0.3-0.01.4-0.1
Bone: trabecular spacing0.10.10.50.6-0.3-0.30.3-0.40.40.70.00.10.5-0.3-0.4-0.40.40.2-0.3
Bone: trabecular thickness0.20.21.11.1-0.6-0.60.60.50.51.00.00.1-0.1-0.1-0.1-0.10.2-0.1-0.3
Bone: trabecular tissue density1.11.63.30.7-1.4-1.41.41.41.40.21.1-1.00.91.21.41.4-0.9-1.81.5
Water consumed over 24 hours0.50.61.90.70.50.5-0.3-0.5-0.31.1-0.30.20.3-1.3-1.4-1.11.1-0.2-1.1
Number of responses in last shaping day0.10.10.60.2-0.4-0.40.30.20.30.1-0.20.30.8-0.20.0-0.10.4-0.6-0.1