Hub : Genes

Atic

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression Atic 0.04 0.03 1.5e-05 0.04 0.03 0.02 0.02 7.9e-05 4.1e-04 8.9e-04 1.0e-03
2 RMTg gene expression Atic 0.1 0.07 5.9e-03 0.09 0.08 0.1 0.1 2.3e-03 4.6e-03 1.3e-03 1.6e-03
3 LHb gene expression Atic 0.53 0.16 1.7e-10 0.28 0.29 0.28 0.29 2.6e-07 1.6e-07 1.7e-07 1.2e-07
4 OFC gene expression Atic 0.7 0.13 8.9e-15 0.4 0.44 0.41 0.48 1.9e-10 1.1e-11 8.3e-11 7.0e-13
5 NAcc gene expression Atic 0.44 0 0.0e+00 0.48 0.49 0.5 0.5 5.7e-83 3.7e-86 2.3e-87 5.8e-87
6 BLA gene expression Atic 0.45 0.13 0.0e+00 0.41 0.43 0.41 0.43 2.4e-23 1.5e-24 1.4e-23 5.6e-25
7 Brain gene expression Atic 0.39 0.11 0.0e+00 0.46 0.48 0.49 0.49 4.9e-47 9.1e-51 4.2e-51 1.5e-51
8 pVTA gene expression Atic 0.59 0 0.0e+00 0.59 0.64 0.63 0.65 5.7e-58 1.8e-66 1.8e-64 1.1e-68
9 Brain mRNA stability Atic 0.12 0.07 7.6e-08 0.08 0.07 0.07 0.09 3.1e-08 2.2e-07 5.0e-07 2.2e-08
10 IC gene expression Atic 0.6 0.18 0.0e+00 0.39 0.48 0.46 0.47 1.1e-17 1.8e-22 2.0e-21 6.9e-22
11 PL gene expression Atic 0.51 0.1 0.0e+00 0.57 0.58 0.58 0.58 4.4e-75 5.6e-78 7.0e-77 6.6e-78
12 IL gene expression Atic 0.63 0.15 1.3e-12 0.35 0.38 0.34 0.35 2.2e-09 3.1e-10 4.6e-09 2.7e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.20.40.8-0.6-0.9-0.9-0.5-0.6-0.6-0.7-0.50.5-0.5-0.5-0.3
Area under the delay curve0.91.11.7-0.9-1.1-1.3-0.8-1.2-1.2-1.3-1.00.9-0.9-0.9-0.7
BMI with tail1.03.54.3-2.0-1.8-1.8-2.1-1.9-1.8-2.0-1.82.0-1.9-1.9-1.6
BMI without tail2.16.47.92.52.52.82.62.72.72.62.8-2.42.42.51.5
Body weight0.20.81.41.21.21.01.00.90.91.00.7-0.80.70.60.4
Weight adjusted by age1.11.62.6-1.6-1.5-1.4-1.1-1.3-1.2-1.4-1.31.1-1.2-1.2-0.9
Bone surface0.30.61.3-0.9-1.2-1.1-0.5-0.7-0.7-0.9-0.70.7-0.6-0.6-0.3
Bone volume0.20.40.8-0.6-0.8-0.9-0.4-0.7-0.7-0.8-0.60.5-0.6-0.6-0.4
Breakpoint value in progressive ratio session0.20.20.4-0.5-0.3-0.4-0.3-0.5-0.5-0.5-0.60.3-0.4-0.5-0.0
Number of licking bursts0.20.41.3-0.4-1.0-0.6-0.4-0.4-0.5-0.7-0.30.4-0.5-0.3-1.1
Context. condit. distance diff. score0.10.10.40.0-0.0-0.3-0.1-0.1-0.2-0.2-0.60.1-0.5-0.5-0.5
Locomotion velocity, session 10.00.00.00.10.20.1-0.00.20.10.10.1-0.00.00.0-0.1
Locomotion distance, session 10.20.20.60.50.30.30.40.50.40.60.8-0.40.60.70.3
Locomotion velocity, session 20.00.00.10.2-0.1-0.10.10.0-0.10.30.2-0.00.10.1-0.2
Locomotion distance, session 20.20.30.7-0.7-0.7-0.8-0.8-0.5-0.6-0.4-0.20.8-0.3-0.3-0.1
Locomotion velocity, session 30.10.10.40.70.40.50.10.30.40.30.3-0.20.30.20.0
Locomotion distance, session 30.20.20.60.80.60.80.40.40.50.30.4-0.40.30.3-0.0
Stereotopy head waving bouts, day 30.10.10.5-0.6-0.5-0.1-0.7-0.2-0.0-0.20.10.50.00.20.1
Stereotopy head waving duration, day 30.30.30.8-0.7-0.9-0.6-0.7-0.6-0.5-0.6-0.30.7-0.4-0.2-0.3
Locomotion velocity, session 70.00.10.1-0.20.00.2-0.40.30.40.10.10.20.20.10.3
Locomotion distance, session 70.20.20.6-0.40.0-0.3-0.5-0.3-0.2-0.5-0.80.5-0.6-0.8-0.3
Stereotopy head waving bouts, day 70.30.30.60.40.20.60.60.40.60.50.8-0.50.60.70.4
Stereotopy head waving duration, day 70.00.00.10.0-0.30.00.1-0.1-0.1-0.00.3-0.10.00.1-0.4
Locomotion velocity, session 82.93.54.0-1.9-2.0-2.0-1.9-1.8-1.9-1.9-2.01.8-1.9-1.8-1.6
Locomotion distance, session 80.40.61.2-0.6-0.7-1.1-0.6-0.7-0.8-0.6-0.90.8-0.8-0.8-0.8
Degree of sensitization distance0.60.61.2-0.9-0.6-0.9-0.8-0.6-0.7-0.8-1.10.8-0.9-1.0-0.4
Degree of sensitization stereotypy0.20.20.80.60.30.40.90.30.30.40.5-0.60.40.30.0
Conditioned locomotion0.91.11.90.81.01.10.81.01.11.11.4-0.81.11.20.9
Cocaine response after cond. corrected5.26.38.32.92.62.72.82.62.52.42.3-2.82.22.21.5
Cocaine response after cond. not corrected2.83.34.72.11.92.22.11.91.91.71.6-2.11.51.51.1
Cocaine response before conditioning3.33.94.9-2.2-2.2-1.8-2.1-2.1-1.9-2.0-2.12.0-1.9-2.0-1.4
Saline control response0.70.92.60.10.31.10.30.81.00.91.2-0.51.21.21.6
Bone: connectivity density0.10.20.6-0.5-0.8-0.6-0.4-0.2-0.2-0.5-0.30.4-0.1-0.10.1
Bone: cortical apparent density0.40.62.6-1.2-0.6-0.2-1.6-0.7-0.4-0.6-0.31.0-0.2-0.30.4
Bone: cortical area0.71.02.51.11.10.61.60.90.91.10.7-1.20.80.81.1
Bone: cortical porosity0.10.10.3-0.2-0.2-0.0-0.3-0.2-0.2-0.3-0.30.4-0.4-0.4-0.6
Bone: cortical porosity0.00.00.10.20.10.30.10.20.20.10.1-0.10.00.0-0.3
Bone: cortical thickness0.71.11.61.01.20.91.31.01.01.20.8-1.10.90.81.2
Bone: cortical thickness1.82.12.51.31.21.51.41.51.61.61.5-1.41.41.41.4
Bone: cortical tissue density0.50.73.2-1.3-0.7-0.3-1.8-0.8-0.6-0.7-0.51.1-0.4-0.40.3
Condit. Reinf. active minus inactive responses1.41.62.71.61.21.21.41.31.01.41.3-1.41.11.30.5
Condit. Reinf. active-inactive response ratio3.53.85.92.42.02.02.12.01.82.01.9-2.21.71.91.0
Condit. Reinf. active responses0.80.91.31.10.90.81.11.10.91.11.0-1.01.01.10.6
Condit. Reinf. inactive responses0.10.10.3-0.6-0.4-0.6-0.1-0.2-0.3-0.3-0.30.4-0.2-0.3-0.2
Incentive salience index mean0.70.81.81.31.00.81.00.90.61.00.8-1.00.80.90.3
Condit. Reinf. lever presses0.20.30.70.70.80.50.40.60.40.50.3-0.50.50.40.5
Condit. Reinf. active minus inactive responses0.00.00.00.00.00.1-0.10.0-0.00.1-0.20.0-0.1-0.0-0.0
Condit. Reinf. active-inactive response ratio0.00.00.20.30.10.2-0.10.10.00.0-0.1-0.0-0.1-0.1-0.4
Condit. Reinf. active responses0.40.51.0-1.0-0.8-0.7-0.9-0.8-0.6-0.6-0.90.8-0.6-0.7-0.1
Condit. Reinf. inactive responses2.63.45.9-2.4-2.3-2.0-2.0-1.9-1.7-1.8-1.91.9-1.5-1.5-0.5
Condit. Reinf. lever presses0.60.81.7-1.3-1.1-0.9-1.2-0.8-0.7-0.8-0.91.1-0.7-0.7-0.2
Condit. Reinf. lever reinforcers received0.10.20.4-0.6-0.5-0.4-0.5-0.4-0.4-0.3-0.60.5-0.3-0.30.1
Conditioned reinforcement - actives0.30.50.8-0.0-0.5-0.8-0.3-0.9-0.9-0.6-0.80.5-0.8-0.8-0.9
Conditioned reinforcement - inactives0.60.91.2-1.0-1.1-0.9-0.7-1.0-0.9-0.8-0.90.8-1.0-1.0-1.0
Conditioned locomotion4.86.27.5-1.9-2.3-2.5-2.4-2.7-2.7-2.5-2.52.4-2.6-2.5-2.6
Patch foraging indifference point 0 sec0.81.44.4-2.1-1.9-1.3-1.0-1.1-0.9-1.2-0.91.0-0.7-0.7-0.1
Patch foraging indifference point AUC1.72.43.0-1.1-1.3-1.7-1.7-1.6-1.6-1.5-1.51.6-1.7-1.7-1.6
Delay disc. indifference point, 0s delay1.31.42.4-1.5-1.2-1.3-1.3-1.2-1.2-1.6-1.21.2-1.0-1.0-0.4
Delay disc. indifference point, 16s delay0.10.20.7-0.3-0.3-0.5-0.2-0.4-0.3-0.9-0.20.3-0.2-0.3-0.2
Delay disc. indifference point, 2s delay4.65.15.8-2.2-2.3-2.4-2.2-2.3-2.4-2.3-2.32.3-2.2-2.2-1.9
Delay disc. indifference point, 24s delay0.40.51.50.1-0.6-0.9-0.2-0.6-0.8-0.6-0.60.4-0.7-0.6-1.2
Delay disc. indifference point, 4s delay2.42.64.1-1.6-1.6-1.6-1.5-1.8-1.7-2.0-1.71.5-1.5-1.6-1.0
Delay disc. indifference point, 8s delay0.00.00.2-0.1-0.1-0.30.3-0.1-0.10.10.1-0.10.20.20.4
Indifference point function ln k1.62.73.61.01.21.81.81.71.91.51.4-1.81.81.71.9
Indifference point function log k1.62.73.61.01.21.81.81.71.91.51.4-1.81.81.71.9
Patch foraging total patch changes 0 sec0.61.13.9-2.0-1.8-1.2-0.8-1.0-0.7-1.0-0.80.8-0.6-0.60.0
Patch foraging total patch changes 12 sec2.93.76.1-2.5-2.4-2.2-2.0-2.0-1.8-1.9-1.62.0-1.7-1.6-1.1
Patch foraging total patch changes 18 sec2.84.37.4-2.4-2.7-2.4-1.8-2.1-2.0-2.1-1.71.9-1.8-1.8-1.7
Patch foraging total patch changes 24 sec0.60.92.5-1.6-1.5-1.1-0.9-0.9-0.8-0.9-0.60.9-0.7-0.6-0.5
Patch foraging total patch changes 6 sec3.35.07.1-2.4-2.7-2.6-2.2-2.3-2.2-2.2-2.12.2-2.1-2.0-1.6
Patch foraging time to switch 0 sec0.71.52.2-0.8-1.1-1.4-1.2-1.3-1.5-1.2-1.11.3-1.2-1.2-1.3
Patch foraging water rate 0 sec0.71.42.20.80.91.31.51.41.51.11.0-1.41.11.10.8
Patch foraging water rate 12 sec0.30.60.70.50.50.80.80.80.90.70.8-0.80.80.90.8
Patch foraging water rate 18 sec1.01.62.20.60.61.21.51.31.41.31.3-1.51.31.41.2
Patch foraging water rate 24 sec0.00.00.1-0.1-0.3-0.20.0-0.1-0.1-0.1-0.3-0.0-0.2-0.1-0.2
Patch foraging water rate 6 sec1.11.72.00.71.01.31.41.31.41.21.4-1.41.41.41.4
Seeking ratio, delayed vs. immediate footshock0.40.50.9-0.5-0.7-1.0-0.5-0.8-0.8-1.0-0.80.6-0.7-0.7-0.5
Distance traveled before self-admin0.00.00.1-0.4-0.1-0.2-0.1-0.2-0.20.1-0.20.1-0.2-0.2-0.2
Distance traveled after self-admin0.20.20.7-0.8-0.5-0.5-0.4-0.5-0.5-0.5-0.50.4-0.4-0.40.1
Extensor digitorum longus weight0.00.10.3-0.0-0.30.2-0.10.30.40.20.6-0.00.40.60.3
Bone: elastic displacement0.10.10.5-0.7-0.5-0.3-0.6-0.2-0.1-0.20.00.5-0.10.00.1
Bone: elastic work0.50.71.6-1.3-1.2-0.9-1.1-0.7-0.5-0.7-0.31.1-0.4-0.3-0.3
Bone: endosteal estimation0.10.30.6-0.7-0.8-0.6-0.4-0.5-0.4-0.7-0.60.4-0.6-0.6-0.4
Bone: endosteal perimeter0.10.21.10.70.30.01.10.50.20.30.2-0.80.20.2-0.0
Epididymis fat weight0.41.42.41.31.51.31.21.21.21.31.2-1.01.00.90.5
Delta time in closed arm before/after self-admin1.51.42.3-1.0-1.3-1.2-1.0-1.2-1.2-1.0-1.11.0-1.3-1.3-1.5
Delta time in open arm before/after self-admin0.70.71.80.90.91.00.70.90.81.40.8-0.80.70.70.3
Diff in mean of infusions in LGA sessions6.68.19.2-3.0-3.0-2.9-2.9-3.0-3.0-2.6-2.92.8-2.8-2.7-2.4
Delay discount exponential model param1.41.62.41.01.31.51.01.41.51.41.3-1.11.21.21.0
Extinction: sum of active levers before priming0.10.10.3-0.30.1-0.1-0.3-0.4-0.4-0.0-0.50.3-0.4-0.50.2
Active lever presses in extinction session 60.00.00.00.20.10.10.0-0.1-0.10.1-0.1-0.1-0.0-0.10.2
Bone: final force0.30.50.90.50.40.41.00.70.70.70.7-0.80.70.70.7
Bone: final moment0.10.10.30.10.10.10.50.40.40.30.4-0.30.30.30.6
Food consumed during 24 hour testing period0.71.02.0-0.6-0.8-1.0-0.9-1.0-1.2-0.2-1.40.9-1.3-1.2-1.1
Glucose0.20.40.70.90.40.60.70.60.50.50.7-0.80.40.5-0.1
Heart weight0.10.20.7-0.8-0.7-0.4-0.4-0.4-0.3-0.3-0.20.4-0.2-0.20.3
Delay discount hyperbolic model param2.12.33.21.21.51.81.31.71.71.71.6-1.41.51.51.2
Intermittent access intake day 1-15 change0.51.13.0-0.6-1.4-0.9-0.8-0.9-1.0-1.0-0.80.8-1.1-0.9-1.7
Intermittent access intake escalation0.71.53.7-0.9-1.6-1.2-0.8-1.1-1.3-1.3-1.10.9-1.3-1.1-1.9
Intermittent access intake escalation 22.12.44.8-1.2-1.9-1.5-1.1-1.5-1.6-1.6-1.51.2-1.7-1.5-2.2
Intermitt. access day 1 inactive lever presses0.62.43.0-1.7-1.2-1.6-1.3-1.6-1.6-1.7-1.71.6-1.7-1.7-1.4
Intermitt. access day 15 inactive lever presses0.00.00.10.1-0.1-0.10.10.10.0-0.20.0-0.0-0.1-0.1-0.3
Intermitt. access escalation Index2.12.93.81.61.81.91.82.01.91.71.8-1.81.61.60.9
Intermittent access day 1 total infusions0.10.20.4-0.7-0.3-0.4-0.6-0.6-0.5-0.2-0.60.6-0.5-0.5-0.0
Intermittent access day 15 total infusions0.50.81.5-0.7-0.9-0.8-0.6-0.9-1.0-0.8-0.90.7-1.0-1.0-1.2
Intermittent access terminal intake (last 3 days)1.52.02.7-1.4-1.6-1.4-1.2-1.5-1.5-1.3-1.41.2-1.5-1.4-1.6
Intermittent access total infusions0.00.00.1-0.2-0.1-0.10.0-0.2-0.20.1-0.20.1-0.2-0.2-0.1
Intermittent access day 1 locomotion0.91.21.9-1.4-0.9-1.0-1.2-1.2-1.1-1.0-1.11.1-1.0-1.1-0.8
Intermittent access day 15 total locomotion2.24.04.9-2.1-2.2-2.0-1.9-2.1-2.1-1.8-1.91.9-2.0-1.9-1.9
Intermittent access total locomotion2.63.13.7-1.9-1.8-1.8-1.6-1.9-1.9-1.6-1.81.6-1.8-1.8-1.6
Intermittent access standard deviation0.50.91.8-0.8-1.3-0.9-0.8-0.9-1.0-0.8-0.90.8-1.0-0.9-1.3
Left kidney weight0.00.20.40.60.4-0.20.6-0.1-0.2-0.1-0.6-0.2-0.4-0.5-0.3
Right kidney weight0.52.43.6-1.3-1.4-1.4-1.4-1.6-1.5-1.6-1.91.5-1.7-1.8-1.2
Cocaine induced anxiety1.52.23.1-1.1-1.1-1.6-1.3-1.6-1.5-1.7-1.81.4-1.6-1.7-1.2
Post-drug Anxiety0.40.40.8-0.1-0.2-0.7-0.5-0.6-0.6-0.9-0.80.6-0.7-0.8-0.6
Baseline Anxiety0.10.10.20.40.20.40.10.30.30.20.4-0.20.20.2-0.2
Tail length5.822.829.55.44.94.95.34.94.85.04.8-4.84.54.53.2
Length with tail1.67.19.73.12.92.73.12.72.72.82.5-2.72.42.31.8
Length without tail0.51.72.7-0.6-1.0-1.4-0.9-1.4-1.5-1.2-1.71.0-1.5-1.6-1.4
Times rat made contact with spout0.50.60.90.40.20.90.70.81.00.70.9-0.80.90.90.9
Lifetime Intake0.00.00.1-0.3-0.1-0.1-0.1-0.3-0.20.1-0.30.1-0.2-0.20.0
Liver weight, left0.61.01.70.80.91.21.01.01.10.90.8-1.11.01.01.3
Liver weight, right0.30.40.70.80.50.70.60.50.70.50.7-0.60.70.70.8
Locomotor activity0.10.20.6-0.7-0.8-0.40.50.10.3-0.10.3-0.30.40.40.7
Locomotor testing distance0.30.52.2-1.3-1.5-1.0-0.3-0.5-0.3-0.7-0.30.4-0.2-0.10.2
Locomotor testing rearing0.10.31.2-1.1-0.9-0.6-0.5-0.4-0.1-0.6-0.10.5-0.0-0.10.4
Locomotion in novel chamber4.05.26.1-2.3-2.2-2.3-2.4-2.5-2.5-2.2-2.42.3-2.2-2.2-1.6
Locomotion in novel chamber post-restriction0.10.20.30.40.50.30.50.40.30.50.3-0.40.30.40.3
Fecal boli incidents, locomotor time 10.20.30.40.50.50.50.50.50.60.40.6-0.50.60.50.4
Change in fecal boli incidents, locomotor task2.02.03.1-1.7-1.6-1.4-1.4-1.4-1.3-1.3-1.41.4-1.3-1.3-1.2
Time >=10cm from walls, locomotor time 11.31.41.90.71.11.21.21.21.21.11.2-1.21.31.21.4
Bouts of movement, locomotor time 14.85.56.81.62.02.42.52.42.52.22.6-2.52.52.52.1
Total resting periods, locomotor time 15.25.87.51.72.02.52.62.52.62.42.7-2.52.62.62.0
Rest time, locomotor task time 10.10.20.30.20.30.50.40.40.30.40.6-0.40.30.3-0.5
Distance moved, locomotor task time 10.10.21.10.10.70.50.10.40.40.40.1-0.30.40.31.1
Vertical activity count, locomotor time 10.00.10.8-0.40.10.0-0.20.10.10.3-0.10.10.20.10.9
Time >=10cm from walls, locomotor time 20.30.40.6-0.6-0.6-0.7-0.6-0.7-0.7-0.8-0.60.7-0.6-0.6-0.5
Bouts of movement, locomotor time 20.10.10.2-0.30.00.50.40.30.4-0.00.3-0.50.40.40.4
Total resting periods, locomotor time 20.10.20.3-0.20.10.50.40.30.50.10.4-0.50.40.40.5
Rest time, locomotor task time 20.91.11.91.31.41.11.01.01.01.21.0-1.00.90.90.6
Distance moved, locomotor task time 21.11.32.0-1.4-1.1-1.0-1.3-1.1-1.2-1.1-1.31.1-1.2-1.2-0.9
Vertical activity count, locomotor time 21.52.13.4-1.9-1.6-1.4-1.4-1.3-1.4-1.4-1.41.4-1.4-1.4-1.3
Light reinforcement 10.30.61.4-0.9-1.2-1.0-0.7-0.7-0.6-0.7-0.80.8-0.7-0.6-0.5
Light reinforcement 20.50.81.3-1.0-1.1-1.1-0.7-0.9-0.8-0.9-1.00.9-0.8-0.8-0.6
Bone: marrow area0.20.30.7-0.8-0.8-0.6-0.4-0.5-0.4-0.7-0.60.4-0.6-0.6-0.4
Bone: maximum diameter0.40.72.40.90.80.21.60.80.60.80.4-1.20.50.50.9
Bone: maximum force0.10.20.5-0.6-0.7-0.6-0.1-0.3-0.2-0.4-0.30.4-0.3-0.3-0.2
Bone: maximum moment0.30.61.1-1.1-1.1-1.0-0.6-0.7-0.6-0.8-0.70.8-0.7-0.7-0.4
Mean time between licks in bursts0.10.20.8-0.20.20.6-0.20.30.5-0.00.7-0.20.70.60.9
Mean num. licks in bursts0.50.82.30.41.01.00.70.71.00.90.7-0.70.90.71.5
Cd content in liver1.92.13.21.51.41.81.31.61.61.41.6-1.41.41.40.8
Co content in liver3.23.75.02.22.22.12.11.91.81.81.8-2.11.71.61.5
Cu content in liver1.11.32.11.00.90.91.11.21.20.91.5-0.91.31.31.1
Fe content in liver0.10.10.20.30.30.50.20.40.30.30.5-0.50.40.50.4
K content in liver0.70.71.5-0.6-0.5-1.0-0.6-0.9-0.9-1.2-0.80.7-0.8-0.9-0.8
Mg content in liver0.40.51.3-0.6-0.7-0.9-0.5-0.6-0.6-1.2-0.40.6-0.5-0.6-0.6
Mn content in liver1.71.93.0-1.6-1.7-1.6-1.4-1.6-1.5-1.1-1.11.4-1.2-1.1-1.0
Na content in liver0.70.73.0-1.1-0.5-1.0-0.9-0.7-0.5-1.7-0.60.8-0.4-0.40.3
Rb content in liver0.10.10.3-0.4-0.1-0.0-0.4-0.1-0.1-0.00.10.30.20.20.6
Se content in liver0.40.50.90.70.60.80.40.70.70.71.0-0.60.80.80.4
Sr content in liver3.22.84.61.11.61.91.11.61.81.31.9-1.41.91.92.1
Zn content in liver0.20.20.40.50.60.30.60.50.5-0.10.5-0.40.40.40.2
Bone: minimum diameter0.10.10.4-0.1-0.4-0.60.3-0.3-0.4-0.1-0.40.0-0.4-0.4-0.4
Time in familiar zone, hab. session 10.10.10.20.50.30.00.3-0.1-0.20.20.0-0.3-0.2-0.2-0.4
Time in novel zone, hab. session 10.10.10.20.1-0.10.20.20.40.50.20.3-0.30.40.40.4
Total zone transitions, hab. session 10.91.21.7-1.0-1.1-1.2-1.3-1.0-1.1-1.0-1.01.2-1.1-1.1-1.1
Total locomotion distance, hab. session 10.50.61.10.90.60.70.70.90.80.91.0-0.70.90.90.5
Locomotion velocity, hab. session 10.60.91.50.90.80.90.81.10.91.01.2-0.71.01.10.7
Time in familiar zone, hab. session 20.20.20.80.90.60.00.80.2-0.10.30.0-0.6-0.1-0.1-0.4
Time in novel zone, hab. session 20.20.20.5-0.6-0.30.4-0.50.10.4-0.00.30.30.40.40.7
Total zone transitions, hab. session 20.10.10.20.50.20.00.30.20.10.40.3-0.20.30.30.3
Total locomotion distance, hab. session 21.11.43.01.71.31.01.31.21.01.31.1-1.21.11.10.7
Locomotion velocity, hab. session 21.01.42.91.71.31.01.31.21.01.21.1-1.11.11.10.7
Novel to familiar place preference ratio0.10.10.2-0.4-0.1-0.1-0.4-0.1-0.0-0.3-0.30.3-0.1-0.1-0.0
Novelty place preference0.00.00.1-0.10.10.1-0.30.10.2-0.1-0.10.10.10.10.1
Time in novel zone, NPP test0.00.00.1-0.10.10.2-0.30.10.2-0.00.00.10.10.20.1
Total zone transitions, NPP test0.10.20.3-0.3-0.4-0.5-0.5-0.3-0.4-0.5-0.30.4-0.4-0.4-0.3
Total locomotion distance, NPP test0.10.10.40.70.40.20.30.40.30.30.4-0.30.30.30.2
Locomotion velocity, NPP test0.00.00.20.40.2-0.00.10.20.10.10.2-0.10.10.10.1
Intraocular pressure0.10.10.7-0.5-0.2-0.1-0.8-0.1-0.1-0.30.00.7-0.1-0.1-0.2
Delta distance traveled before/after self-admin0.00.00.1-0.3-0.2-0.1-0.3-0.2-0.2-0.2-0.20.3-0.1-0.20.1
Delta ambulatory time before/after self-admin0.00.00.10.10.10.1-0.1-0.0-0.0-0.1-0.10.00.0-0.00.4
Parametrial fat weight2.45.79.92.73.22.82.02.52.42.52.2-2.22.12.01.8
Pavlov. Cond. lever latency0.10.10.4-0.5-0.7-0.3-0.1-0.3-0.1-0.2-0.10.1-0.2-0.1-0.2
Pavlov. Cond. magazine entry latency0.20.20.3-0.1-0.2-0.4-0.4-0.4-0.6-0.3-0.50.5-0.5-0.5-0.5
Pavlov. Cond. change in total contacts0.10.10.70.80.70.20.30.2-0.00.2-0.0-0.1-0.1-0.1-0.5
Pavlov. Cond. index score0.00.00.30.40.50.00.00.1-0.10.1-0.20.1-0.1-0.1-0.1
Pavlov. Cond. latency score0.00.10.10.30.4-0.1-0.2-0.1-0.3-0.0-0.30.3-0.2-0.3-0.2
Pavlov. Cond. lever contacts0.10.10.50.60.70.40.10.30.20.30.2-0.20.20.20.2
Pavlov. Cond. magazine entry number0.81.01.40.60.71.10.91.11.20.91.2-1.11.11.11.1
Pavlov. Cond. intertrial magazine entries2.12.63.31.01.21.51.61.71.81.61.8-1.61.81.81.6
Pavlov. Cond. lever-magazine prob. diff.0.00.10.30.50.60.10.10.20.00.2-0.1-0.00.0-0.0-0.1
Pavlov. Cond. response bias0.00.00.10.20.30.0-0.1-0.0-0.10.0-0.20.2-0.1-0.2-0.2
Pavlov. Cond. lever latency0.40.51.01.01.00.60.90.60.60.50.8-0.80.50.50.1
Pavlov. Cond. magazine entry latency0.30.30.6-0.3-0.7-0.5-0.5-0.5-0.6-0.4-0.70.4-0.5-0.5-0.7
Pavlov. Cond. change in total contacts0.00.00.1-0.3-0.4-0.1-0.2-0.2-0.20.1-0.30.1-0.0-0.00.3
Pavlov. Cond. index score0.30.40.8-0.8-0.9-0.5-0.9-0.6-0.6-0.4-0.70.6-0.4-0.4-0.0
Pavlov. Cond. latency score0.30.40.9-0.8-0.9-0.5-0.9-0.6-0.6-0.5-0.70.7-0.4-0.5-0.2
Pavlov. Cond. lever contacts0.40.61.1-1.0-1.0-0.7-1.0-0.7-0.6-0.6-0.90.8-0.6-0.6-0.1
Pavlov. Cond. magazine entry number0.10.10.30.40.60.30.50.30.40.20.5-0.20.30.30.2
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.20.00.00.00.00.1-0.10.10.0-0.00.0-0.0
Pavlov. Cond. lever-magazine prob. diff.0.30.40.9-0.9-0.9-0.5-1.0-0.6-0.6-0.4-0.70.6-0.4-0.40.0
Pavlov. Cond. response bias0.50.71.3-1.1-1.2-0.8-1.0-0.8-0.8-0.6-1.00.8-0.6-0.7-0.2
Time in closed arm before self-admin0.60.81.20.91.10.90.90.90.90.80.8-0.80.90.80.9
Time in closed arm after self-admin0.00.00.10.20.30.20.20.20.2-0.20.1-0.20.20.10.2
Time in open arm before self-admin2.42.74.0-2.0-1.9-1.8-1.7-1.7-1.6-1.8-1.51.6-1.4-1.4-0.9
Time in open arm after self-admin0.00.00.1-0.1-0.20.1-0.1-0.0-0.00.3-0.00.00.00.00.0
Bone: periosteal estimation0.10.20.70.30.20.10.80.40.40.30.2-0.60.20.20.5
Bone: periosteal perimeter1.73.05.31.81.71.42.31.81.61.81.6-2.01.51.51.5
Bone: post-yield work0.10.10.2-0.3-0.4-0.4-0.1-0.1-0.1-0.5-0.40.2-0.4-0.4-0.4
Progressive ratio test 1 active lever presses0.00.00.1-0.00.20.1-0.2-0.1-0.10.3-0.00.10.10.00.4
Progressive ratio test 1 breakpoint0.00.00.1-0.20.0-0.1-0.3-0.2-0.20.2-0.20.2-0.1-0.10.3
Progressive ratio test 1 inactive lever presses0.00.10.20.20.50.30.10.20.20.30.2-0.10.20.20.3
Progressive ratio test 2 active lever presses0.20.20.4-0.5-0.3-0.5-0.3-0.6-0.6-0.3-0.50.4-0.5-0.4-0.1
Progressive ratio test 2 breakpoint0.20.20.4-0.6-0.4-0.5-0.4-0.7-0.6-0.3-0.50.4-0.5-0.5-0.1
Progressive ratio test 2 inactive lever presses0.30.50.7-0.9-0.7-0.7-0.6-0.8-0.7-0.6-0.80.6-0.8-0.8-0.7
Incentive Sensitization - Responses0.00.00.1-0.3-0.2-0.4-0.1-0.3-0.2-0.2-0.10.2-0.1-0.00.2
Incentive Sensitization - Breakpoint0.00.00.1-0.3-0.1-0.30.0-0.2-0.1-0.1-0.00.10.00.10.4
Sum of active levers in priming session hrs 5-60.00.00.2-0.5-0.20.0-0.0-0.1-0.0-0.0-0.10.00.10.00.4
Progressive ratio1.92.93.91.92.01.81.61.61.61.81.7-1.71.71.71.5
Food seeking constrained by brief footshock0.20.20.6-0.5-0.8-0.4-0.5-0.4-0.4-0.4-0.20.3-0.3-0.2-0.7
Seeking ratio, punishment vs. effort1.21.72.3-1.4-1.5-1.3-1.3-1.2-1.2-1.3-1.41.2-1.4-1.3-1.3
Retroperitoneal fat weight2.39.714.53.53.83.53.03.23.23.13.1-3.02.92.72.1
Reaction time number correct0.30.71.10.60.30.80.90.80.90.80.9-1.10.81.00.5
Reaction time mean minus median1.43.54.9-2.2-2.0-2.0-1.8-1.8-1.7-2.1-1.81.8-1.8-1.8-1.5
Reaction time mean minus median AUC0.82.14.3-2.1-1.7-1.6-1.4-1.3-1.2-1.7-1.21.4-1.2-1.3-0.9
Reaction time num false alarms0.00.10.30.60.10.10.00.20.10.20.2-0.0-0.00.1-0.4
Reaction time num false alarms AUC0.00.10.30.5-0.0-0.2-0.2-0.0-0.10.0-0.00.2-0.2-0.1-0.6
Reaction time trials correct on left0.30.71.10.60.30.80.90.80.90.80.9-1.10.81.00.5
Reaction time trials on left0.30.61.10.60.30.80.90.80.90.80.9-1.10.81.00.4
Reaction time mean0.10.10.20.20.40.30.30.40.40.20.3-0.40.30.30.3
Reaction time mean AUC0.00.10.2-0.00.30.20.20.30.30.00.2-0.20.20.10.4
Median of all reaction times0.91.31.81.11.31.21.11.31.21.11.1-1.11.11.11.0
Reaction time omissions0.10.10.30.40.30.30.50.40.30.30.6-0.40.30.3-0.0
Reaction time false alarm rate0.10.20.50.3-0.0-0.4-0.5-0.3-0.4-0.3-0.40.6-0.5-0.5-0.7
Reaction time premature initiation rate0.81.21.6-1.3-1.1-1.2-1.2-1.0-1.0-1.2-1.01.2-0.9-1.0-0.7
Reaction time premature initiations0.20.40.9-0.9-0.9-0.8-0.7-0.6-0.5-0.8-0.50.6-0.5-0.5-0.4
Std. dev. reaction times0.81.52.2-1.5-1.2-1.3-1.3-1.1-1.1-1.4-1.01.2-1.2-1.2-1.0
Reaction time trials completed0.30.61.10.60.30.80.90.80.90.80.9-1.10.81.00.4
Reaction time trials AUC0.61.21.80.90.61.11.21.11.11.11.2-1.41.11.30.6
Run reversals in cocaine runway, females0.40.40.90.50.30.60.70.60.70.50.9-0.70.60.70.2
Run reversals in cocaine runway, males0.40.40.7-0.5-0.6-0.6-0.7-0.6-0.6-0.6-0.50.7-0.6-0.6-0.8
Latency to leave start box in cocaine runway1.01.11.7-1.3-0.9-0.9-1.3-1.1-1.0-1.1-1.11.2-0.9-1.0-0.3
Latency to leave start box in cocaine runway, F0.60.71.4-1.2-0.8-0.8-0.9-0.9-0.8-0.8-0.90.9-0.6-0.8-0.1
Latency to leave start box in cocaine runway, M0.70.71.4-0.7-0.6-0.5-1.2-0.8-0.7-0.9-0.91.0-0.8-0.9-0.5
Std. dev. time between licks in bursts0.20.31.1-1.0-1.0-0.6-0.2-0.4-0.3-0.6-0.30.1-0.2-0.1-0.1
Total sessions with >9 infusions0.30.41.0-1.0-0.7-0.7-0.7-0.7-0.6-0.5-0.60.6-0.5-0.40.1
Short access day 1 total inactive lever presses0.40.61.5-1.2-0.8-0.6-0.9-0.7-0.6-0.8-0.70.7-0.6-0.7-0.0
Short access day 10 total inactive lever presses0.20.40.6-0.4-0.6-0.7-0.5-0.6-0.7-0.7-0.70.7-0.8-0.7-0.8
Short access day 1 total infusions0.20.21.0-1.0-0.6-0.5-0.3-0.4-0.4-0.2-0.40.2-0.3-0.20.3
Short access day 10 total infusions0.00.00.3-0.5-0.1-0.00.1-0.1-0.00.1-0.1-0.10.0-0.00.4
Short access total infusions0.20.30.8-0.9-0.5-0.5-0.5-0.6-0.5-0.4-0.50.4-0.4-0.40.1
Short access day 1 locomotion0.60.82.1-1.4-1.3-0.9-0.7-0.9-0.9-0.8-0.60.7-0.7-0.6-0.5
Short access day 10 total locomotion1.93.44.3-2.1-1.8-1.9-1.9-2.0-1.9-1.8-1.91.9-1.8-1.8-1.4
Short access total locomotion1.72.13.2-1.8-1.5-1.4-1.6-1.6-1.5-1.4-1.31.5-1.3-1.3-0.9
One hour access (0.3 mA shock)0.10.10.60.80.50.20.50.0-0.00.3-0.0-0.3-0.1-0.1-0.3
Compulsive drug intake1.21.52.11.41.41.01.21.21.21.01.1-1.11.21.21.3
One hour access (shock baseline)0.00.10.20.1-0.1-0.10.0-0.3-0.30.0-0.2-0.0-0.3-0.3-0.5
Social response proportion0.10.10.70.90.30.00.40.20.10.20.1-0.2-0.00.1-0.5
Social responses0.20.30.90.2-0.3-0.7-0.1-0.4-0.6-0.4-0.40.3-0.6-0.6-0.9
Social time1.52.12.51.61.51.51.61.31.31.51.5-1.51.41.41.2
Soleus weight0.10.40.7-0.7-0.8-0.8-0.7-0.4-0.5-0.7-0.50.8-0.4-0.4-0.4
Bone: stiffness0.10.20.70.50.10.20.80.40.40.40.2-0.60.20.20.2
Tibialis anterior weight0.30.91.3-0.6-0.8-0.9-0.9-0.9-0.9-1.0-0.90.9-1.0-1.0-1.1
Time to tail flick, vehicle, before self-admin0.40.40.7-0.8-0.7-0.5-0.7-0.7-0.7-0.5-0.80.7-0.7-0.7-0.4
Time to tail flick, vehicle, after self-admin0.20.30.80.70.80.60.40.60.50.90.5-0.20.50.40.3
Time to tail flick, test, before self-admin0.60.60.90.10.30.70.90.80.90.61.0-0.80.90.90.8
Time to tail flick, test, after self-admin0.00.00.10.1-0.1-0.1-0.1-0.2-0.3-0.1-0.30.1-0.3-0.3-0.3
Delta time to tail flick, vehicle, before/after SA1.21.11.41.11.21.01.01.11.21.21.2-0.81.01.00.7
Delta time to tail flick, test, before/after SA0.60.60.9-0.1-0.4-0.7-0.8-0.8-0.9-0.5-0.90.7-0.9-0.9-0.9
Tibia length0.61.52.2-1.4-1.2-1.5-1.1-1.4-1.2-1.3-1.31.3-1.2-1.3-0.5
Ambulatory time before self-admin0.00.00.1-0.3-0.0-0.2-0.1-0.1-0.1-0.1-0.10.1-0.2-0.2-0.2
Ambulatory time after self-admin0.10.10.3-0.5-0.1-0.2-0.3-0.3-0.2-0.3-0.30.2-0.2-0.30.2
Bone: tissue strength0.40.40.6-0.4-0.5-0.6-0.7-0.6-0.6-0.6-0.60.8-0.5-0.6-0.8
Total heroin consumption0.10.20.60.3-0.1-0.1-0.3-0.3-0.4-0.0-0.40.3-0.5-0.5-0.8
Bone: trabecular number1.22.13.0-1.4-1.7-1.7-1.3-1.4-1.4-1.5-1.31.5-1.3-1.3-1.2
Bone: trabecular spacing3.14.16.01.92.42.41.71.92.02.12.0-1.91.91.91.9
Bone: trabecular thickness0.10.20.60.60.40.10.70.40.30.30.2-0.60.30.30.2
Bone: trabecular tissue density0.40.61.70.30.70.80.30.60.80.70.9-0.60.90.91.3
Water consumed over 24 hours0.00.10.10.2-0.30.0-0.2-0.3-0.20.1-0.30.0-0.3-0.2-0.3
Number of responses in last shaping day0.00.00.1-0.1-0.1-0.1-0.0-0.1-0.1-0.1-0.1-0.0-0.0-0.00.3