Hub : Genes

Atf4

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	Atf4	0.02	0.01	9.1e-04	0.02	0.02	0.01	0.01	1.6e-03	4.4e-04	2.9e-03	5.6e-03
2	Adipose	mRNA stability	Atf4	0.04	0.02	4.5e-04	0.02	0.03	0.03	0.03	1.6e-03	2.1e-04	4.6e-04	5.6e-04
3	LHb	alternative TSS	NM_024403.2	0.36	0.16	1.9e-03	0.13	0.09	0.04	0.1	4.5e-04	3.2e-03	4.7e-02	2.7e-03
4	LHb	alternative TSS	XM_039079942.2	0.35	0.16	1.6e-03	0.14	0.1	0.08	0.11	3.5e-04	2.7e-03	5.5e-03	1.4e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.0	0.0	0.1	0.4	-0.1	-0.1	0.1
Area under the delay curve	0.6	1.0	2.3	1.5	-0.8	0.7	-0.7
BMI with tail	0.5	1.6	4.2	-2.1	0.2	-1.1	1.1
BMI without tail	0.2	0.9	1.4	-0.5	0.5	-1.2	1.2
Body weight	0.6	2.5	9.3	-3.0	-0.6	-0.4	0.4
Weight adjusted by age	0.1	0.2	0.5	0.3	0.7	-0.4	0.4
Bone surface	0.2	0.4	0.4	0.6	-0.6	0.6	-0.6
Bone volume	0.0	0.0	0.1	0.1	-0.3	0.0	-0.0
Breakpoint value in progressive ratio session	0.1	0.3	0.3	-0.3	-0.6	0.6	-0.6
Number of licking bursts	0.2	0.7	2.3	1.5	0.2	-0.4	0.4
Context. condit. distance diff. score	2.8	3.3	9.9	-3.1	1.0	-1.1	1.1
Locomotion velocity, session 1	1.2	1.4	1.9	0.5	-1.4	1.3	-1.3
Locomotion distance, session 1	1.4	1.8	6.4	2.5	-0.5	0.4	-0.4
Locomotion velocity, session 2	0.2	0.3	0.4	-0.5	-0.7	0.4	-0.4
Locomotion distance, session 2	2.5	3.5	6.4	2.5	-1.5	1.6	-1.6
Locomotion velocity, session 3	1.5	1.8	2.2	-0.9	1.4	-1.5	1.5
Locomotion distance, session 3	2.6	3.0	3.6	1.2	1.8	-1.9	1.9
Stereotopy head waving bouts, day 3	1.2	1.4	2.3	-1.0	-1.5	1.1	-1.1
Stereotopy head waving duration, day 3	2.3	2.8	5.2	-2.3	-1.8	1.2	-1.2
Locomotion velocity, session 7	0.2	0.3	1.0	-1.0	0.2	-0.1	0.1
Locomotion distance, session 7	0.7	0.8	1.3	0.0	-0.9	1.1	-1.1
Stereotopy head waving bouts, day 7	2.1	2.4	4.5	-2.1	0.8	-1.5	1.5
Stereotopy head waving duration, day 7	2.5	3.0	5.0	-2.2	1.1	-1.7	1.7
Locomotion velocity, session 8	1.1	1.3	2.6	-1.6	-1.2	0.8	-0.8
Locomotion distance, session 8	0.3	0.4	0.9	-0.9	0.7	-0.4	0.4
Degree of sensitization distance	4.5	4.8	5.9	-1.8	-2.0	2.4	-2.4
Degree of sensitization stereotypy	2.0	2.2	3.3	-1.8	1.0	-1.5	1.5
Conditioned locomotion	0.1	0.1	0.5	-0.7	-0.0	0.2	-0.2
Cocaine response after cond. corrected	0.7	1.0	1.6	-0.3	-0.9	1.3	-1.3
Cocaine response after cond. not corrected	0.3	0.5	0.9	-0.2	-0.4	0.9	-0.9
Cocaine response before conditioning	0.9	1.0	1.4	0.3	1.1	-1.2	1.2
Saline control response	0.4	0.6	1.6	-0.1	1.3	-0.6	0.6
Bone: connectivity density	0.1	0.2	0.3	0.1	-0.5	0.5	-0.5
Bone: cortical apparent density	1.7	2.6	3.3	0.9	1.8	-1.8	1.8
Bone: cortical area	1.2	2.0	2.7	-1.3	-1.6	1.3	-1.3
Bone: cortical porosity	0.9	1.0	1.6	-1.3	-0.5	1.1	-1.1
Bone: cortical porosity	2.5	2.8	3.6	-1.9	-1.3	1.7	-1.7
Bone: cortical thickness	0.3	0.4	0.8	-0.3	-0.9	0.7	-0.7
Bone: cortical thickness	1.0	1.2	2.3	0.3	-1.5	1.1	-1.1
Bone: cortical tissue density	1.5	2.3	2.9	0.8	1.7	-1.7	1.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.3	0.5	-0.1	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.4	0.4	-0.2	0.2
Condit. Reinf. active responses	0.5	0.6	1.7	1.3	0.6	-0.5	0.5
Condit. Reinf. inactive responses	1.3	1.6	2.7	1.6	1.1	-1.2	1.2
Incentive salience index mean	0.1	0.2	0.7	0.8	0.0	0.1	-0.1
Condit. Reinf. lever presses	0.2	0.2	0.7	0.8	0.2	-0.3	0.3
Condit. Reinf. active minus inactive responses	1.5	2.3	2.9	0.6	-1.7	1.7	-1.7
Condit. Reinf. active-inactive response ratio	1.4	2.2	3.0	-0.1	-1.7	1.7	-1.7
Condit. Reinf. active responses	1.4	1.9	2.7	-0.1	-1.6	1.6	-1.6
Condit. Reinf. inactive responses	0.2	0.3	0.5	-0.4	-0.7	0.5	-0.5
Condit. Reinf. lever presses	0.2	0.2	0.7	0.8	-0.3	0.4	-0.4
Condit. Reinf. lever reinforcers received	1.5	2.1	2.9	-0.0	-1.6	1.7	-1.7
Conditioned reinforcement - actives	0.2	1.0	1.4	0.6	-1.2	1.0	-1.0
Conditioned reinforcement - inactives	1.0	2.8	3.7	1.6	-1.9	1.6	-1.6
Conditioned locomotion	1.9	2.8	4.4	-0.3	-2.1	1.8	-1.8
Patch foraging indifference point 0 sec	0.1	0.4	0.5	0.6	-0.3	0.7	-0.7
Patch foraging indifference point AUC	0.5	1.2	3.7	1.9	-0.8	0.4	-0.4
Delay disc. indifference point, 0s delay	0.8	0.9	1.0	-0.9	-0.8	1.0	-1.0
Delay disc. indifference point, 16s delay	0.8	1.2	3.9	2.0	-0.5	0.5	-0.5
Delay disc. indifference point, 2s delay	0.4	0.5	0.6	0.8	-0.7	0.6	-0.6
Delay disc. indifference point, 24s delay	0.5	0.8	1.5	1.2	-1.1	0.5	-0.5
Delay disc. indifference point, 4s delay	0.7	0.7	0.8	0.9	-0.9	0.8	-0.8
Delay disc. indifference point, 8s delay	0.5	0.9	3.1	1.8	-0.5	0.3	-0.3
Indifference point function ln k	0.5	1.6	4.7	-2.2	1.0	-0.7	0.7
Indifference point function log k	0.5	1.6	4.7	-2.2	1.0	-0.7	0.7
Patch foraging total patch changes 0 sec	0.1	0.3	0.7	0.8	-0.1	0.4	-0.4
Patch foraging total patch changes 12 sec	0.9	1.2	1.9	0.4	-0.9	1.4	-1.4
Patch foraging total patch changes 18 sec	1.2	2.9	3.6	1.0	-1.9	1.9	-1.9
Patch foraging total patch changes 24 sec	0.2	0.5	1.2	1.1	-0.4	0.6	-0.6
Patch foraging total patch changes 6 sec	1.2	2.0	2.5	1.6	-1.5	1.3	-1.3
Patch foraging time to switch 0 sec	0.1	0.4	0.7	-0.8	-0.3	0.7	-0.7
Patch foraging water rate 0 sec	0.0	0.1	0.4	0.6	-0.3	0.1	-0.1
Patch foraging water rate 12 sec	0.1	0.6	1.0	0.5	1.0	-0.7	0.7
Patch foraging water rate 18 sec	0.1	0.3	1.3	1.1	0.0	0.1	-0.1
Patch foraging water rate 24 sec	0.1	0.2	0.6	-0.8	0.3	-0.2	0.2
Patch foraging water rate 6 sec	1.1	1.6	2.7	1.1	1.6	-1.2	1.2
Seeking ratio, delayed vs. immediate footshock	0.6	0.9	1.2	0.8	0.7	-1.1	1.1
Distance traveled before self-admin	0.2	0.4	0.5	0.6	-0.5	0.7	-0.7
Distance traveled after self-admin	1.3	2.4	3.1	0.7	-1.6	1.8	-1.8
Extensor digitorum longus weight	0.3	1.4	1.6	1.3	1.1	-1.2	1.2
Bone: elastic displacement	0.0	0.0	0.1	-0.2	0.1	0.1	-0.1
Bone: elastic work	2.2	2.9	3.0	-1.7	-1.7	1.7	-1.7
Bone: endosteal estimation	1.1	2.6	3.0	-1.3	-1.7	1.7	-1.7
Bone: endosteal perimeter	0.9	2.1	4.2	-2.0	-1.2	1.2	-1.2
Epididymis fat weight	0.9	4.5	17.4	-4.2	-0.6	0.2	-0.2
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.1	-0.7	0.5	-0.5
Delta time in open arm before/after self-admin	0.1	0.1	0.4	0.6	0.2	0.0	-0.0
Diff in mean of infusions in LGA sessions	0.3	0.6	1.2	-0.3	-1.1	0.7	-0.7
Delay discount exponential model param	0.7	0.9	2.5	-1.6	0.7	-0.6	0.6
Extinction: sum of active levers before priming	0.9	1.3	2.2	-0.8	-1.5	1.1	-1.1
Active lever presses in extinction session 6	0.3	0.3	0.4	-0.6	-0.6	0.5	-0.5
Bone: final force	1.9	3.2	4.8	-1.3	-2.2	1.8	-1.8
Bone: final moment	2.3	3.7	5.5	-1.3	-2.3	1.9	-1.9
Food consumed during 24 hour testing period	1.0	2.1	2.8	-1.3	-1.7	1.4	-1.4
Glucose	0.2	0.4	0.5	-0.6	-0.2	0.7	-0.7
Heart weight	1.8	2.9	5.6	-2.4	-1.8	1.2	-1.2
Delay discount hyperbolic model param	0.6	0.8	2.3	-1.5	0.6	-0.5	0.5
Intermittent access intake day 1-15 change	0.1	0.5	0.6	0.5	0.7	-0.8	0.8
Intermittent access intake escalation	0.1	0.8	0.9	0.7	0.9	-1.0	1.0
Intermittent access intake escalation 2	0.3	0.5	0.6	0.6	0.7	-0.8	0.8
Intermitt. access day 1 inactive lever presses	0.2	2.6	4.1	-0.6	-1.4	2.0	-2.0
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.1	0.9	-1.0	1.0	-1.0
Intermitt. access escalation Index	0.3	0.9	1.2	0.7	0.9	-1.1	1.1
Intermittent access day 1 total infusions	1.2	3.6	4.9	0.1	-2.2	2.2	-2.2
Intermittent access day 15 total infusions	0.3	0.6	1.2	1.1	-0.7	0.7	-0.7
Intermittent access terminal intake (last 3 days)	0.4	0.6	0.8	0.9	-0.8	0.7	-0.7
Intermittent access total infusions	2.7	3.2	4.6	0.6	-2.1	2.0	-2.0
Intermittent access day 1 locomotion	1.0	1.8	3.0	0.4	-1.7	1.4	-1.4
Intermittent access day 15 total locomotion	0.4	1.5	2.8	-0.3	-1.7	1.3	-1.3
Intermittent access total locomotion	2.2	2.6	4.9	-0.2	-2.2	1.7	-1.7
Intermittent access standard deviation	0.7	3.6	5.5	-0.5	-1.7	2.3	-2.3
Left kidney weight	2.2	18.0	48.1	-6.9	-3.1	2.6	-2.6
Right kidney weight	3.2	22.2	59.1	-7.7	-3.5	2.9	-2.9
Cocaine induced anxiety	0.3	0.9	2.6	-1.6	-0.9	0.0	-0.0
Post-drug Anxiety	0.5	0.6	0.8	-0.7	0.3	-0.9	0.9
Baseline Anxiety	0.7	1.2	2.7	1.6	1.1	-0.6	0.6
Tail length	0.1	0.6	0.7	0.6	0.8	-0.8	0.8
Length with tail	0.2	0.7	2.8	-1.7	-0.1	-0.1	0.1
Length without tail	0.8	4.1	9.3	-3.0	-1.8	1.4	-1.4
Times rat made contact with spout	0.1	0.1	0.4	0.3	-0.6	-0.1	0.1
Lifetime Intake	3.9	4.8	7.2	0.1	-2.7	2.5	-2.5
Liver weight, left	0.6	1.1	1.6	-1.3	1.0	-0.9	0.9
Liver weight, right	3.0	5.3	7.3	-2.7	2.1	-2.2	2.2
Locomotor activity	0.5	0.8	2.7	-1.6	-0.5	0.3	-0.3
Locomotor testing distance	0.1	0.2	0.3	0.3	0.4	-0.5	0.5
Locomotor testing rearing	0.2	0.7	2.4	-1.5	-0.4	0.4	-0.4
Locomotion in novel chamber	3.3	4.5	5.6	1.5	2.4	-2.2	2.2
Locomotion in novel chamber post-restriction	0.3	0.8	1.0	0.8	1.0	-0.9	0.9
Fecal boli incidents, locomotor time 1	0.9	2.3	2.9	0.9	-1.7	1.6	-1.6
Change in fecal boli incidents, locomotor task	0.6	0.7	0.9	-0.6	0.6	-1.0	1.0
Time >=10cm from walls, locomotor time 1	1.1	1.4	1.6	-0.9	-1.2	1.3	-1.3
Bouts of movement, locomotor time 1	0.3	0.4	1.3	-1.1	-0.5	0.2	-0.2
Total resting periods, locomotor time 1	0.5	0.6	0.8	-0.9	-0.8	0.7	-0.7
Rest time, locomotor task time 1	1.0	1.6	1.8	-1.0	-1.3	1.3	-1.3
Distance moved, locomotor task time 1	0.4	1.1	1.3	-0.5	1.1	-1.1	1.1
Vertical activity count, locomotor time 1	0.0	0.2	0.4	-0.0	0.3	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	0.0	-0.4	0.3	-0.3
Bouts of movement, locomotor time 2	0.1	0.4	0.5	-0.7	0.4	-0.7	0.7
Total resting periods, locomotor time 2	0.0	0.1	0.3	-0.5	-0.0	-0.3	0.3
Rest time, locomotor task time 2	0.4	0.6	0.8	0.4	-0.8	0.9	-0.9
Distance moved, locomotor task time 2	0.4	0.5	0.8	-0.9	0.8	-0.5	0.5
Vertical activity count, locomotor time 2	0.0	0.1	0.3	-0.6	-0.1	-0.1	0.1
Light reinforcement 1	0.0	0.1	0.1	0.4	-0.3	0.3	-0.3
Light reinforcement 2	0.6	1.3	2.1	-1.4	1.0	-1.0	1.0
Bone: marrow area	1.2	2.8	3.3	-1.3	-1.8	1.8	-1.8
Bone: maximum diameter	2.6	5.2	6.7	-2.6	-2.4	2.1	-2.1
Bone: maximum force	2.8	5.6	9.0	-1.5	-3.0	2.3	-2.3
Bone: maximum moment	3.3	6.2	9.7	-1.6	-3.1	2.5	-2.5
Mean time between licks in bursts	0.1	0.5	0.9	1.0	0.9	-0.4	0.4
Mean num. licks in bursts	0.2	0.6	2.2	-1.5	-0.5	0.1	-0.1
Cd content in liver	0.1	0.1	0.1	-0.4	-0.2	-0.2	0.2
Co content in liver	0.5	0.6	0.8	0.9	-0.9	0.7	-0.7
Cu content in liver	2.3	2.7	8.3	2.9	0.7	-1.0	1.0
Fe content in liver	1.3	1.7	2.0	-1.4	-1.3	1.2	-1.2
K content in liver	0.4	0.4	0.9	0.9	0.6	-0.4	0.4
Mg content in liver	0.1	0.1	0.5	0.7	-0.1	-0.1	0.1
Mn content in liver	0.5	0.5	0.7	0.0	0.8	-0.8	0.8
Na content in liver	0.3	0.4	1.1	1.0	0.3	-0.4	0.4
Rb content in liver	0.7	0.8	1.7	0.3	-1.3	0.8	-0.8
Se content in liver	2.2	2.7	3.8	0.5	1.7	-1.9	1.9
Sr content in liver	3.3	2.8	3.4	1.8	1.6	-1.6	1.6
Zn content in liver	0.2	0.3	0.4	0.4	0.2	-0.6	0.6
Bone: minimum diameter	1.1	2.1	2.6	-1.0	-1.5	1.6	-1.6
Time in familiar zone, hab. session 1	0.5	0.6	0.9	0.3	-0.9	0.9	-0.9
Time in novel zone, hab. session 1	0.4	0.5	1.0	-1.0	0.5	-0.6	0.6
Total zone transitions, hab. session 1	2.7	3.8	6.5	2.5	1.8	-1.7	1.7
Total locomotion distance, hab. session 1	1.6	2.3	2.9	1.7	1.7	-1.3	1.3
Locomotion velocity, hab. session 1	1.4	1.9	3.7	1.9	1.3	-1.1	1.1
Time in familiar zone, hab. session 2	1.4	1.6	2.2	0.1	1.5	-1.4	1.4
Time in novel zone, hab. session 2	1.4	1.6	2.1	-0.1	-1.4	1.5	-1.5
Total zone transitions, hab. session 2	1.1	1.5	3.2	1.8	-1.0	0.9	-0.9
Total locomotion distance, hab. session 2	1.2	1.6	2.5	1.6	-0.8	1.3	-1.3
Locomotion velocity, hab. session 2	1.4	1.9	3.7	1.9	-0.8	1.3	-1.3
Novel to familiar place preference ratio	0.5	0.6	1.6	-1.3	0.2	-0.6	0.6
Novelty place preference	0.8	1.1	2.4	-1.6	0.4	-0.9	0.9
Time in novel zone, NPP test	1.1	1.3	3.0	-1.7	0.3	-1.0	1.0
Total zone transitions, NPP test	1.7	2.5	8.4	2.9	0.8	-0.7	0.7
Total locomotion distance, NPP test	0.7	1.0	3.7	1.9	0.1	0.4	-0.4
Locomotion velocity, NPP test	0.9	1.2	4.8	2.2	0.4	0.2	-0.2
Intraocular pressure	0.3	0.5	1.1	-1.0	-0.3	0.6	-0.6
Delta distance traveled before/after self-admin	0.7	0.7	1.2	-0.5	-1.1	0.8	-0.8
Delta ambulatory time before/after self-admin	0.7	1.2	2.0	-0.4	-1.4	1.1	-1.1
Parametrial fat weight	0.8	2.0	2.7	-0.4	1.5	-1.7	1.7
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	-0.3	-0.1	0.1
Pavlov. Cond. magazine entry latency	0.3	0.4	0.9	0.9	-0.3	0.6	-0.6
Pavlov. Cond. change in total contacts	1.0	1.1	1.9	1.4	-0.9	1.0	-1.0
Pavlov. Cond. index score	0.4	0.5	0.7	0.6	-0.5	0.8	-0.8
Pavlov. Cond. latency score	0.2	0.3	0.3	0.5	-0.3	0.6	-0.6
Pavlov. Cond. lever contacts	0.3	0.3	1.0	1.0	0.2	0.3	-0.3
Pavlov. Cond. magazine entry number	0.3	0.4	1.2	-1.1	0.3	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.5	0.6	1.9	1.4	-0.4	0.3	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	0.7	-0.3	0.6	-0.6
Pavlov. Cond. response bias	0.3	0.4	0.8	0.9	-0.3	0.6	-0.6
Pavlov. Cond. lever latency	0.1	0.1	0.4	-0.6	0.1	-0.3	0.3
Pavlov. Cond. magazine entry latency	1.0	1.4	3.0	1.7	-0.9	1.0	-1.0
Pavlov. Cond. change in total contacts	1.6	4.0	5.7	0.1	-2.2	2.4	-2.4
Pavlov. Cond. index score	0.6	0.9	1.5	1.2	-0.7	0.9	-0.9
Pavlov. Cond. latency score	0.7	1.1	2.1	1.5	-0.7	0.9	-0.9
Pavlov. Cond. lever contacts	0.1	0.2	0.5	0.7	-0.0	0.2	-0.2
Pavlov. Cond. magazine entry number	0.4	0.5	1.2	-1.1	0.5	-0.5	0.5
Pavlov. Cond. intertrial magazine entries	0.4	1.0	1.1	-1.0	-1.1	0.9	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.4	1.2	-0.6	0.7	-0.7
Pavlov. Cond. response bias	0.5	0.6	0.7	0.9	-0.7	0.8	-0.8
Time in closed arm before self-admin	0.4	0.7	2.8	1.7	0.2	-0.1	0.1
Time in closed arm after self-admin	0.3	0.3	0.5	-0.2	-0.7	0.5	-0.5
Time in open arm before self-admin	0.4	0.5	0.8	-0.0	0.9	-0.8	0.8
Time in open arm after self-admin	1.2	1.4	1.7	0.6	1.3	-1.3	1.3
Bone: periosteal estimation	1.5	3.6	4.3	-1.7	-2.1	1.9	-1.9
Bone: periosteal perimeter	2.1	4.1	7.1	-2.7	-1.7	1.7	-1.7
Bone: post-yield work	1.2	2.1	5.4	0.2	-2.3	1.3	-1.3
Progressive ratio test 1 active lever presses	1.5	2.7	4.3	0.4	-2.1	1.8	-1.8
Progressive ratio test 1 breakpoint	1.3	2.3	3.6	0.5	-1.9	1.6	-1.6
Progressive ratio test 1 inactive lever presses	1.9	5.0	7.2	0.5	-2.3	2.7	-2.7
Progressive ratio test 2 active lever presses	1.7	2.4	3.7	0.5	-1.9	1.7	-1.7
Progressive ratio test 2 breakpoint	1.8	2.3	3.4	0.6	-1.8	1.6	-1.6
Progressive ratio test 2 inactive lever presses	0.3	1.0	2.1	1.5	-0.8	0.7	-0.7
Incentive Sensitization - Responses	0.1	0.2	0.4	0.7	-0.1	0.3	-0.3
Incentive Sensitization - Breakpoint	0.1	0.2	0.2	0.5	-0.3	0.4	-0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.0	-0.1	0.0	0.2	-0.2
Progressive ratio	0.1	0.2	0.4	0.2	-0.7	0.4	-0.4
Food seeking constrained by brief footshock	0.3	0.4	0.9	-0.7	-0.9	0.2	-0.2
Seeking ratio, punishment vs. effort	0.1	0.2	0.4	-0.6	-0.4	0.4	-0.4
Retroperitoneal fat weight	1.5	6.8	26.4	-5.1	-0.8	0.2	-0.2
Reaction time number correct	0.7	2.6	3.6	0.7	1.9	-1.8	1.8
Reaction time mean minus median	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2
Reaction time mean minus median AUC	0.0	0.3	0.9	-1.0	0.3	0.1	-0.1
Reaction time num false alarms	0.1	0.2	0.3	-0.0	0.6	-0.5	0.5
Reaction time num false alarms AUC	0.2	0.4	0.6	0.2	0.8	-0.7	0.7
Reaction time trials correct on left	0.7	2.6	3.6	0.7	1.9	-1.8	1.8
Reaction time trials on left	0.8	2.7	3.7	0.8	1.9	-1.8	1.8
Reaction time mean	0.0	0.0	0.0	-0.1	0.2	-0.0	0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.1	0.2	-0.1	0.1
Median of all reaction times	0.0	0.0	0.1	-0.0	0.2	-0.1	0.1
Reaction time omissions	0.2	0.2	0.7	0.9	0.5	-0.1	0.1
Reaction time false alarm rate	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0
Reaction time premature initiation rate	2.4	3.8	6.0	0.0	-1.8	2.4	-2.4
Reaction time premature initiations	0.4	1.3	2.3	0.1	-0.8	1.5	-1.5
Std. dev. reaction times	0.0	0.1	0.3	-0.6	0.1	0.1	-0.1
Reaction time trials completed	0.8	2.7	3.7	0.8	1.9	-1.8	1.8
Reaction time trials AUC	0.6	2.1	2.9	0.5	1.7	-1.6	1.6
Run reversals in cocaine runway, females	0.2	0.2	0.6	0.3	0.8	-0.4	0.4
Run reversals in cocaine runway, males	0.1	0.2	0.3	-0.4	-0.5	0.3	-0.3
Latency to leave start box in cocaine runway	0.3	0.5	1.3	-1.2	0.6	-0.3	0.3
Latency to leave start box in cocaine runway, F	0.0	0.0	0.1	-0.2	0.3	-0.0	0.0
Latency to leave start box in cocaine runway, M	0.9	0.9	2.4	-1.6	0.7	-0.6	0.6
Std. dev. time between licks in bursts	0.3	0.5	1.6	1.3	-0.4	0.4	-0.4
Total sessions with >9 infusions	4.6	5.7	8.1	-1.6	-2.8	2.5	-2.5
Short access day 1 total inactive lever presses	3.8	7.6	11.4	0.3	-3.4	3.1	-3.1
Short access day 10 total inactive lever presses	0.1	0.6	0.7	-0.6	-0.8	0.8	-0.8
Short access day 1 total infusions	1.5	2.9	4.2	-0.4	-2.1	1.9	-1.9
Short access day 10 total infusions	2.4	3.9	5.0	-1.1	-2.2	2.2	-2.2
Short access total infusions	4.3	6.1	9.5	-1.0	-3.1	2.7	-2.7
Short access day 1 locomotion	0.7	1.2	1.6	-0.2	-1.2	1.3	-1.3
Short access day 10 total locomotion	0.5	1.9	3.2	0.5	-1.0	1.8	-1.8
Short access total locomotion	1.7	2.5	3.5	-0.6	-1.6	1.9	-1.9
One hour access (0.3 mA shock)	0.7	0.8	1.8	1.4	-0.8	0.6	-0.6
Compulsive drug intake	0.4	0.6	1.9	1.4	0.1	-0.4	0.4
One hour access (shock baseline)	0.1	0.3	0.4	0.1	-0.5	0.6	-0.6
Social response proportion	0.2	0.2	0.3	-0.6	-0.1	0.5	-0.5
Social responses	0.5	0.7	0.9	0.8	-0.5	0.9	-0.9
Social time	0.9	1.3	3.6	1.9	-0.1	0.9	-0.9
Soleus weight	0.3	1.0	1.5	1.2	-0.9	1.0	-1.0
Bone: stiffness	1.8	3.3	5.2	-1.4	-2.3	1.7	-1.7
Tibialis anterior weight	0.5	1.7	6.2	2.5	0.3	-0.4	0.4
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.5	0.1	-0.7	0.7	-0.7
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.8	0.9	0.3	-0.1	0.1
Time to tail flick, test, before self-admin	0.1	0.1	0.2	-0.4	0.3	-0.3	0.3
Time to tail flick, test, after self-admin	0.8	0.8	1.2	0.6	0.7	-1.1	1.1
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.3	0.2	-0.4	0.5	-0.5
Delta time to tail flick, test, before/after SA	1.6	2.0	2.5	1.6	1.1	-1.4	1.4
Tibia length	0.8	2.1	2.7	-1.2	-1.7	1.5	-1.5
Ambulatory time before self-admin	0.1	0.2	0.9	1.0	0.1	0.1	-0.1
Ambulatory time after self-admin	0.6	0.9	2.1	1.5	-0.7	0.7	-0.7
Bone: tissue strength	0.1	0.1	0.4	-0.6	-0.1	-0.1	0.1
Total heroin consumption	0.5	0.5	1.3	0.0	-1.1	0.7	-0.7
Bone: trabecular number	0.2	0.3	0.4	-0.2	0.6	-0.6	0.6
Bone: trabecular spacing	2.2	3.2	5.0	-0.8	-2.2	1.9	-1.9
Bone: trabecular thickness	0.8	1.1	1.6	-0.0	1.2	-1.2	1.2
Bone: trabecular tissue density	0.6	1.1	1.6	1.3	0.9	-1.0	1.0
Water consumed over 24 hours	0.2	0.4	1.0	0.3	-1.0	0.4	-0.4
Number of responses in last shaping day	2.2	2.9	3.9	0.6	-1.8	2.0	-2.0