Hub : Genes

Atf3

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	NM_012912.2	0.03	0.02	1.5e-03	0.02	0.02	0.02	0.02	2.6e-03	9.7e-04	5.2e-03	3.2e-03
2	Liver	alternative polyA	XM_039090385.2	0.03	0.02	2.4e-03	0.02	0.02	0.01	0.02	5.0e-03	1.4e-03	8.3e-03	6.5e-03
3	Liver	gene expression	Atf3	0.09	0.06	7.0e-08	0.05	0.06	0.06	0.06	1.4e-06	3.1e-07	3.8e-07	2.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	0.3	0.5	0.8	-0.9	0.9	0.0
Area under the delay curve	1.1	1.3	1.4	-1.2	1.2	-1.0
BMI with tail	0.0	0.1	0.2	0.3	-0.3	0.5
BMI without tail	1.1	3.3	4.1	-2.0	2.0	-1.4
Body weight	3.3	14.2	14.9	-3.8	3.9	-3.6
Weight adjusted by age	0.8	1.1	1.2	-1.1	1.1	-1.0
Bone surface	0.2	0.3	0.5	-0.7	0.7	-0.3
Bone volume	0.6	1.1	1.6	-1.3	1.2	-0.5
Breakpoint value in progressive ratio session	1.2	1.5	1.9	-1.4	1.3	-0.9
Number of licking bursts	0.1	0.2	0.2	-0.5	0.5	0.3
Context. condit. distance diff. score	0.4	0.4	0.6	-0.8	0.7	-0.4
Locomotion velocity, session 1	0.1	0.1	0.2	0.2	-0.3	0.4
Locomotion distance, session 1	0.0	0.0	0.1	-0.1	-0.0	0.3
Locomotion velocity, session 2	0.6	0.7	0.9	-1.0	0.9	-0.6
Locomotion distance, session 2	0.0	0.0	0.0	-0.2	0.2	-0.2
Locomotion velocity, session 3	2.0	2.3	2.5	-1.6	1.6	-1.4
Locomotion distance, session 3	0.8	0.9	0.9	-0.9	1.0	-0.9
Stereotopy head waving bouts, day 3	0.8	0.9	1.2	0.9	-0.9	1.1
Stereotopy head waving duration, day 3	0.3	0.4	1.0	0.1	-0.3	1.0
Locomotion velocity, session 7	0.4	0.4	0.6	0.6	-0.5	-0.8
Locomotion distance, session 7	0.2	0.3	0.4	0.6	-0.5	-0.4
Stereotopy head waving bouts, day 7	1.1	1.2	1.7	-1.3	1.2	-0.6
Stereotopy head waving duration, day 7	1.1	1.3	2.0	-1.4	1.3	-0.3
Locomotion velocity, session 8	0.1	0.1	0.2	-0.3	0.2	0.4
Locomotion distance, session 8	0.2	0.2	0.3	-0.5	0.5	-0.4
Degree of sensitization distance	1.1	1.2	1.4	1.2	-1.2	0.8
Degree of sensitization stereotypy	1.2	1.3	1.9	-1.4	1.3	-0.6
Conditioned locomotion	1.2	1.4	2.1	1.0	-1.0	1.4
Cocaine response after cond. corrected	0.1	0.2	0.2	0.4	-0.4	0.4
Cocaine response after cond. not corrected	0.2	0.2	0.5	0.3	-0.3	0.7
Cocaine response before conditioning	0.2	0.3	0.4	-0.7	0.6	-0.0
Saline control response	1.6	2.1	3.2	-1.8	1.7	-0.4
Bone: connectivity density	0.3	0.5	0.7	-0.9	0.8	0.4
Bone: cortical apparent density	0.1	0.2	0.2	0.4	-0.4	-0.4
Bone: cortical area	2.6	4.0	4.5	-2.1	2.1	-1.8
Bone: cortical porosity	0.2	0.2	0.7	-0.1	0.0	0.8
Bone: cortical porosity	0.2	0.3	0.8	0.1	-0.1	0.9
Bone: cortical thickness	0.8	1.3	1.7	-1.3	1.2	-0.8
Bone: cortical thickness	1.9	2.3	3.3	-1.8	1.7	-0.7
Bone: cortical tissue density	0.1	0.2	0.2	0.5	-0.4	-0.4
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	0.0	0.0	-0.2
Condit. Reinf. active-inactive response ratio	0.6	0.6	0.8	0.7	-0.7	0.9
Condit. Reinf. active responses	0.9	1.1	1.7	-0.9	0.9	-1.3
Condit. Reinf. inactive responses	1.9	2.3	2.9	-1.4	1.4	-1.7
Incentive salience index mean	0.5	0.6	0.7	-0.7	0.8	-0.8
Condit. Reinf. lever presses	1.9	2.6	3.0	-1.7	1.7	-1.5
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.7	0.6	0.1
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.4	0.6	-0.6	0.6
Condit. Reinf. active responses	0.7	1.0	1.4	-1.2	1.2	-0.5
Condit. Reinf. inactive responses	2.5	3.2	3.6	-1.9	1.9	-1.6
Condit. Reinf. lever presses	1.7	2.4	2.9	-1.7	1.7	-1.2
Condit. Reinf. lever reinforcers received	0.7	0.9	1.2	-1.1	1.1	-0.7
Conditioned reinforcement - actives	0.6	1.0	1.4	-1.2	1.1	-0.7
Conditioned reinforcement - inactives	1.2	1.8	2.2	-1.5	1.5	-1.0
Conditioned locomotion	1.0	1.3	1.9	-1.4	1.3	-0.5
Patch foraging indifference point 0 sec	1.8	3.3	5.0	-2.2	2.1	-0.5
Patch foraging indifference point AUC	0.4	0.6	0.9	0.9	-0.9	0.3
Delay disc. indifference point, 0s delay	0.3	0.3	0.4	-0.6	0.6	-0.5
Delay disc. indifference point, 16s delay	2.5	2.8	3.6	-1.9	1.9	-1.2
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	-0.5	0.4	0.0
Delay disc. indifference point, 24s delay	2.8	3.1	3.5	-1.9	1.9	-1.5
Delay disc. indifference point, 4s delay	0.6	0.7	1.3	-0.6	0.6	-1.1
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.3	0.3	0.0
Indifference point function ln k	0.1	0.1	0.1	-0.3	0.2	0.4
Indifference point function log k	0.1	0.1	0.1	-0.3	0.2	0.4
Patch foraging total patch changes 0 sec	1.7	3.2	4.9	-2.2	2.1	-0.6
Patch foraging total patch changes 12 sec	2.0	2.5	3.2	-1.8	1.8	-1.1
Patch foraging total patch changes 18 sec	0.5	0.8	0.8	-0.9	0.9	-0.9
Patch foraging total patch changes 24 sec	1.3	2.2	2.5	-1.6	1.6	-1.3
Patch foraging total patch changes 6 sec	2.0	3.0	3.8	-2.0	2.0	-1.2
Patch foraging time to switch 0 sec	0.2	0.3	0.5	0.5	-0.5	-0.7
Patch foraging water rate 0 sec	0.4	0.9	1.2	-1.1	1.0	0.7
Patch foraging water rate 12 sec	0.2	0.3	0.5	-0.7	0.7	0.1
Patch foraging water rate 18 sec	0.4	0.6	0.9	-1.0	0.9	-0.1
Patch foraging water rate 24 sec	0.0	0.1	0.1	-0.2	0.1	0.4
Patch foraging water rate 6 sec	0.5	0.7	1.1	-1.0	1.0	0.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.5	-0.7	0.7	-0.6
Distance traveled before self-admin	0.4	0.5	0.6	-0.8	0.7	0.6
Distance traveled after self-admin	0.1	0.2	0.3	-0.4	0.3	0.5
Extensor digitorum longus weight	0.1	0.4	1.0	-0.2	0.3	-1.0
Bone: elastic displacement	1.2	1.4	2.0	1.0	-1.1	1.4
Bone: elastic work	0.5	0.7	1.1	0.7	-0.7	1.0
Bone: endosteal estimation	0.1	0.1	0.2	-0.2	0.2	-0.5
Bone: endosteal perimeter	0.8	1.7	2.4	-1.1	1.2	-1.6
Epididymis fat weight	0.3	1.0	1.6	-1.3	1.2	-0.3
Delta time in closed arm before/after self-admin	0.6	0.5	0.8	0.9	-0.9	0.2
Delta time in open arm before/after self-admin	5.0	4.9	5.5	-2.3	2.3	-2.0
Diff in mean of infusions in LGA sessions	0.6	0.8	1.2	-1.1	1.0	-0.2
Delay discount exponential model param	1.3	1.5	1.6	1.3	-1.3	1.1
Extinction: sum of active levers before priming	4.2	4.6	5.3	-2.3	2.3	-1.8
Active lever presses in extinction session 6	2.3	2.3	2.6	-1.6	1.6	-1.3
Bone: final force	0.4	0.6	0.6	-0.8	0.8	-0.8
Bone: final moment	0.7	1.1	1.2	-1.0	1.0	-1.1
Food consumed during 24 hour testing period	0.1	0.1	0.2	-0.5	0.4	-0.1
Glucose	1.1	1.8	1.8	1.3	-1.3	1.3
Heart weight	2.4	3.7	4.0	-2.0	2.0	-1.8
Delay discount hyperbolic model param	1.5	1.7	1.9	1.4	-1.4	1.2
Intermittent access intake day 1-15 change	1.6	3.2	4.2	2.0	-2.0	1.2
Intermittent access intake escalation	1.7	3.4	4.1	2.0	-2.0	1.4
Intermittent access intake escalation 2	0.7	0.8	1.0	0.9	-1.0	0.8
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.1	0.1	-0.4
Intermitt. access day 15 inactive lever presses	1.1	2.3	2.7	-1.4	1.5	-1.6
Intermitt. access escalation Index	0.2	0.3	1.0	-0.1	0.1	-1.0
Intermittent access day 1 total infusions	1.9	3.1	3.8	-1.9	1.9	-1.3
Intermittent access day 15 total infusions	0.2	0.3	0.4	0.5	-0.5	0.6
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.4	-0.4	0.2
Intermittent access total infusions	0.1	0.1	0.1	-0.4	0.3	0.1
Intermittent access day 1 locomotion	1.5	1.9	2.2	-1.5	1.4	-1.2
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.4	0.3	-0.2
Intermittent access total locomotion	0.5	0.6	0.9	-0.9	0.9	-0.5
Intermittent access standard deviation	0.0	0.0	0.0	0.1	-0.1	-0.1
Left kidney weight	2.1	9.8	10.6	-3.2	3.2	-2.9
Right kidney weight	1.6	7.3	7.8	-2.8	2.8	-2.5
Cocaine induced anxiety	1.7	2.5	4.8	-1.1	1.2	-2.2
Post-drug Anxiety	0.3	0.4	0.9	-0.3	0.3	-1.0
Baseline Anxiety	5.1	5.9	8.9	2.0	-2.2	3.0
Tail length	5.5	21.6	22.8	-4.7	4.8	-4.4
Length with tail	6.3	27.5	27.7	-5.2	5.3	-5.3
Length without tail	1.5	4.7	6.1	-2.0	2.0	-2.5
Times rat made contact with spout	0.1	0.1	0.1	-0.4	0.3	0.3
Lifetime Intake	0.3	0.3	0.6	-0.7	0.7	-0.1
Liver weight, left	0.6	1.0	1.1	-1.0	1.0	-0.9
Liver weight, right	0.2	0.3	1.0	0.1	-0.2	1.0
Locomotor activity	0.7	1.1	1.1	1.0	-1.1	1.0
Locomotor testing distance	0.4	0.7	0.7	0.8	-0.9	0.8
Locomotor testing rearing	0.1	0.1	0.1	-0.4	0.3	0.3
Locomotion in novel chamber	0.0	0.0	0.0	0.1	-0.1	0.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.3	0.2	0.4
Fecal boli incidents, locomotor time 1	0.8	1.1	1.4	1.2	-1.2	0.7
Change in fecal boli incidents, locomotor task	0.1	0.1	0.3	-0.5	0.4	-0.1
Time >=10cm from walls, locomotor time 1	0.8	0.9	1.2	0.8	-0.9	1.1
Bouts of movement, locomotor time 1	0.7	0.8	1.0	0.8	-0.9	1.0
Total resting periods, locomotor time 1	0.6	0.7	0.7	0.8	-0.8	0.8
Rest time, locomotor task time 1	1.1	1.4	1.6	1.2	-1.3	1.1
Distance moved, locomotor task time 1	0.3	0.5	0.8	-0.6	0.6	-0.9
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.1	0.1	0.3
Time >=10cm from walls, locomotor time 2	0.1	0.1	0.1	0.3	-0.3	-0.4
Bouts of movement, locomotor time 2	0.4	0.7	0.8	0.9	-0.9	0.7
Total resting periods, locomotor time 2	0.3	0.5	0.7	0.8	-0.8	0.5
Rest time, locomotor task time 2	3.7	4.7	5.9	2.4	-2.4	1.5
Distance moved, locomotor task time 2	1.3	1.6	1.9	-1.3	1.4	-1.0
Vertical activity count, locomotor time 2	0.3	0.4	0.7	-0.8	0.8	0.0
Light reinforcement 1	0.3	0.7	1.6	0.5	-0.6	1.2
Light reinforcement 2	0.5	0.8	1.3	0.7	-0.8	1.1
Bone: marrow area	0.0	0.0	0.1	-0.1	0.1	-0.3
Bone: maximum diameter	1.4	2.7	3.1	-1.8	1.7	-1.4
Bone: maximum force	0.3	0.4	0.6	-0.8	0.7	-0.5
Bone: maximum moment	0.5	0.9	1.0	-1.0	1.0	-0.8
Mean time between licks in bursts	0.6	1.6	2.5	1.6	-1.5	-0.1
Mean num. licks in bursts	0.1	0.1	0.1	0.3	-0.3	-0.3
Cd content in liver	15.5	17.2	19.5	-4.4	4.4	-3.6
Co content in liver	0.4	0.5	1.2	0.3	-0.4	1.1
Cu content in liver	5.4	6.4	7.8	2.8	-2.8	1.9
Fe content in liver	1.7	2.1	3.1	1.7	-1.7	0.6
K content in liver	0.6	0.6	0.8	0.9	-0.9	0.3
Mg content in liver	0.3	0.3	0.4	-0.6	0.6	-0.4
Mn content in liver	1.0	1.1	1.3	-1.1	1.1	-0.9
Na content in liver	2.0	2.1	3.0	1.7	-1.7	0.7
Rb content in liver	0.9	1.0	1.6	1.2	-1.2	0.3
Se content in liver	0.3	0.3	0.5	-0.7	0.6	0.3
Sr content in liver	1.5	1.3	2.0	-0.9	1.0	-1.4
Zn content in liver	3.9	4.3	6.5	-2.6	2.4	-0.8
Bone: minimum diameter	2.5	4.6	5.4	-2.0	2.1	-2.3
Time in familiar zone, hab. session 1	0.1	0.1	0.2	0.4	-0.3	-0.5
Time in novel zone, hab. session 1	1.4	1.4	1.6	-1.3	1.2	-1.0
Total zone transitions, hab. session 1	1.6	2.3	2.7	-1.6	1.6	-1.3
Total locomotion distance, hab. session 1	0.1	0.1	0.2	-0.2	0.2	-0.4
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.0	-0.0	-0.0
Time in familiar zone, hab. session 2	0.5	0.5	0.8	0.9	-0.9	0.2
Time in novel zone, hab. session 2	2.5	2.5	2.9	-1.7	1.7	-1.3
Total zone transitions, hab. session 2	0.9	1.2	1.3	-1.2	1.1	-0.9
Total locomotion distance, hab. session 2	0.1	0.2	0.4	-0.3	0.3	-0.6
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.3	0.3	-0.4
Novel to familiar place preference ratio	0.5	0.6	0.9	-1.0	0.9	0.0
Novelty place preference	0.9	1.0	1.5	-1.2	1.2	-0.2
Time in novel zone, NPP test	1.0	1.1	1.7	-1.3	1.2	-0.3
Total zone transitions, NPP test	1.8	2.6	3.5	-1.9	1.8	-1.0
Total locomotion distance, NPP test	0.5	0.7	0.9	-0.9	0.9	-0.7
Locomotion velocity, NPP test	0.3	0.5	0.6	-0.8	0.7	-0.5
Intraocular pressure	1.2	1.7	2.2	1.2	-1.2	1.5
Delta distance traveled before/after self-admin	0.1	0.1	0.3	-0.2	0.2	-0.5
Delta ambulatory time before/after self-admin	0.0	0.1	0.1	0.3	-0.3	-0.1
Parametrial fat weight	0.0	0.0	0.1	0.0	0.0	-0.3
Pavlov. Cond. lever latency	4.6	5.8	6.9	2.6	-2.6	1.9
Pavlov. Cond. magazine entry latency	3.9	5.0	7.2	-1.9	2.0	-2.7
Pavlov. Cond. change in total contacts	6.1	6.5	7.3	-2.7	2.7	-2.2
Pavlov. Cond. index score	4.1	5.2	5.4	-2.3	2.3	-2.2
Pavlov. Cond. latency score	4.5	5.7	6.1	-2.4	2.5	-2.3
Pavlov. Cond. lever contacts	2.7	3.2	3.8	-1.9	1.9	-1.5
Pavlov. Cond. magazine entry number	3.9	5.0	7.1	1.9	-2.0	2.7
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	0.7	-0.7	0.9
Pavlov. Cond. lever-magazine prob. diff.	4.3	5.3	5.5	-2.3	2.4	-2.3
Pavlov. Cond. response bias	4.2	5.2	6.1	-2.2	2.2	-2.5
Pavlov. Cond. lever latency	2.7	3.7	4.6	2.1	-2.1	1.4
Pavlov. Cond. magazine entry latency	0.5	0.6	0.7	-0.8	0.9	-0.7
Pavlov. Cond. change in total contacts	0.3	0.5	0.7	-0.8	0.8	-0.3
Pavlov. Cond. index score	1.9	2.5	3.0	-1.7	1.7	-1.3
Pavlov. Cond. latency score	2.0	2.7	3.1	-1.8	1.8	-1.4
Pavlov. Cond. lever contacts	2.1	2.8	3.6	-1.9	1.9	-1.2
Pavlov. Cond. magazine entry number	0.6	0.7	0.9	1.0	-1.0	0.6
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	-0.1	0.1	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.4	1.9	2.3	-1.5	1.5	-1.0
Pavlov. Cond. response bias	1.3	1.8	2.2	-1.5	1.5	-1.0
Time in closed arm before self-admin	0.1	0.1	0.3	0.1	-0.1	0.6
Time in closed arm after self-admin	2.6	2.8	3.2	1.8	-1.8	1.5
Time in open arm before self-admin	0.1	0.1	0.2	-0.3	0.3	-0.5
Time in open arm after self-admin	5.0	5.5	6.1	-2.5	2.5	-2.1
Bone: periosteal estimation	1.1	2.4	2.5	-1.6	1.6	-1.5
Bone: periosteal perimeter	1.5	2.6	2.7	-1.6	1.6	-1.6
Bone: post-yield work	0.0	0.0	0.0	-0.0	0.0	0.1
Progressive ratio test 1 active lever presses	1.4	1.8	2.2	-1.2	1.3	-1.5
Progressive ratio test 1 breakpoint	1.4	1.7	1.9	-1.2	1.2	-1.4
Progressive ratio test 1 inactive lever presses	2.4	3.4	4.2	-1.7	1.8	-2.1
Progressive ratio test 2 active lever presses	0.7	0.8	0.9	-0.9	0.9	-0.9
Progressive ratio test 2 breakpoint	0.6	0.6	0.7	-0.8	0.8	-0.8
Progressive ratio test 2 inactive lever presses	1.7	2.8	3.2	-1.8	1.7	-1.5
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.4	0.4	-0.7
Incentive Sensitization - Breakpoint	0.2	0.3	0.5	-0.4	0.3	-0.7
Sum of active levers in priming session hrs 5-6	3.1	2.8	3.4	-1.8	1.8	-1.4
Progressive ratio	1.6	2.5	3.7	-1.9	1.7	0.9
Food seeking constrained by brief footshock	0.3	0.3	0.6	0.7	-0.7	0.1
Seeking ratio, punishment vs. effort	1.7	2.5	3.9	2.0	-1.8	-0.6
Retroperitoneal fat weight	1.0	4.3	4.8	-2.2	2.2	-1.8
Reaction time number correct	2.3	4.5	6.5	-2.5	2.5	-0.9
Reaction time mean minus median	2.5	6.3	7.1	2.6	-2.7	2.2
Reaction time mean minus median AUC	2.1	5.3	6.0	2.4	-2.4	2.0
Reaction time num false alarms	2.2	3.1	3.7	1.9	-1.9	1.4
Reaction time num false alarms AUC	2.3	3.7	4.1	2.0	-2.0	1.7
Reaction time trials correct on left	2.3	4.5	6.5	-2.5	2.5	-0.9
Reaction time trials on left	2.2	4.1	6.0	-2.5	2.4	-0.8
Reaction time mean	6.4	10.1	13.0	3.6	-3.6	2.1
Reaction time mean AUC	5.9	9.5	11.7	3.4	-3.4	2.2
Median of all reaction times	5.4	7.6	10.3	3.2	-3.2	1.6
Reaction time omissions	2.2	3.3	4.1	1.7	-1.7	2.0
Reaction time false alarm rate	4.5	6.1	7.8	2.8	-2.8	1.7
Reaction time premature initiation rate	0.3	0.4	0.5	0.7	-0.6	-0.5
Reaction time premature initiations	0.2	0.3	0.3	-0.5	0.5	-0.5
Std. dev. reaction times	4.8	8.9	10.0	3.1	-3.2	2.7
Reaction time trials completed	2.2	4.1	6.0	-2.5	2.4	-0.8
Reaction time trials AUC	2.4	4.6	6.7	-2.6	2.5	-0.9
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.1	0.2	-0.4
Run reversals in cocaine runway, males	1.0	1.0	1.4	1.2	-1.2	0.5
Latency to leave start box in cocaine runway	1.5	1.7	2.0	1.4	-1.4	1.1
Latency to leave start box in cocaine runway, F	3.4	3.9	4.6	2.1	-2.1	1.6
Latency to leave start box in cocaine runway, M	0.0	0.0	0.1	-0.1	0.1	-0.3
Std. dev. time between licks in bursts	0.2	0.2	0.6	0.3	-0.2	-0.8
Total sessions with >9 infusions	1.9	2.3	2.8	-1.7	1.7	-1.2
Short access day 1 total inactive lever presses	0.0	0.1	0.2	-0.1	0.1	-0.4
Short access day 10 total inactive lever presses	0.3	0.8	1.2	-0.8	0.8	-1.1
Short access day 1 total infusions	0.7	1.0	1.3	-1.1	1.1	-0.7
Short access day 10 total infusions	1.0	1.3	1.7	-1.3	1.3	-0.6
Short access total infusions	1.1	1.4	2.1	-1.4	1.4	-0.5
Short access day 1 locomotion	3.6	4.5	6.0	-2.5	2.4	-1.3
Short access day 10 total locomotion	0.2	0.4	0.5	0.7	-0.7	0.4
Short access total locomotion	0.4	0.5	0.8	-0.9	0.9	-0.3
One hour access (0.3 mA shock)	1.1	1.2	1.7	-1.0	1.0	-1.3
Compulsive drug intake	1.0	1.2	2.6	-0.7	0.8	-1.6
One hour access (shock baseline)	0.1	0.2	0.3	0.3	-0.4	0.6
Social response proportion	0.1	0.1	0.2	0.3	-0.3	0.5
Social responses	0.4	0.6	0.8	-0.9	0.9	-0.3
Social time	0.1	0.1	0.2	-0.4	0.4	0.1
Soleus weight	1.6	4.6	9.7	1.3	-1.5	3.1
Bone: stiffness	0.7	1.2	1.2	-1.1	1.1	-1.0
Tibialis anterior weight	0.5	1.6	2.7	-1.0	1.1	-1.6
Time to tail flick, vehicle, before self-admin	2.4	2.5	3.4	1.8	-1.8	0.9
Time to tail flick, vehicle, after self-admin	0.4	0.5	0.7	-0.8	0.8	-0.5
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.4	-0.4	0.4
Time to tail flick, test, after self-admin	0.3	0.3	0.4	0.6	-0.7	0.2
Delta time to tail flick, vehicle, before/after SA	1.5	1.5	1.9	-1.4	1.3	-0.8
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.1	-0.1	0.1
Tibia length	1.9	5.2	5.9	-2.2	2.3	-2.4
Ambulatory time before self-admin	0.4	0.6	1.7	-0.1	0.0	1.3
Ambulatory time after self-admin	0.7	0.9	2.0	0.5	-0.6	1.4
Bone: tissue strength	0.7	0.7	1.1	1.0	-1.0	-0.1
Total heroin consumption	3.4	4.0	5.0	-2.2	2.2	-1.5
Bone: trabecular number	0.2	0.3	0.4	-0.4	0.4	0.7
Bone: trabecular spacing	0.8	1.1	2.5	-0.6	0.6	-1.6
Bone: trabecular thickness	0.2	0.3	0.4	-0.5	0.5	0.7
Bone: trabecular tissue density	1.2	1.8	2.8	1.7	-1.5	-0.5
Water consumed over 24 hours	0.6	0.7	1.1	-1.1	1.0	-0.3
Number of responses in last shaping day	0.2	0.3	0.6	-0.4	0.3	0.7